Cells

Article	Citations
Osteoblast-Osteoclast Communication and Bone Homeostasis	509
A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping	359
Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications	359
Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19	282
Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration	275
Latest Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing	261
Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death	260
Management of Rheumatoid Arthritis: An Overview	258
Biomarkers in Hepatocellular Carcinoma: Diagnosis, Prognosis and Treatment Response Assessment	247
Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy	243
Influence of Nitrogen and Phosphorus on Microalgal Growth, Biomass, Lipid, and Fatty Acid Production: An Overview	228
The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability	224
High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review	219
The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management	217
Hyaluronic Acid: Redefining Its Role	216
Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19	211
Methods for Separation and Characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee	210
Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation	206
Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets	205
COVID-19, Renin-Angiotensin System and Endothelial Dysfunction	203
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives	197
Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control, Adhesion and Invasion in Tumor and Stroma	196
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine	190
Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics	176
Microglia: Agents of the CNS Pro-Inflammatory Response	174

Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and Angiogenesis	173
COVID-19: Characteristics and Therapeutics	172
Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair	167
Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis	164
Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs	163
Reactive Oxygen Species and Redox Signaling in Chronic Kidney Disease	162
Helicobacter pylori Virulence Factors—Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment	162
Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis	160
Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease	159
Macrophages in Lung Injury, Repair, and Fibrosis	156
The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer	156
The Role of MSC in Wound Healing, Scarring and Regeneration	155
Loop-Mediated Isothermal Amplification (LAMP): The Better Sibling of PCR?	147
Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19	145
Lysosomal Biology and Function: Modern View of Cellular Debris Bin	144
New Onset of Autoimmune Diseases Following COVID-19 Diagnosis	141
Cancer Stem Cell Functions in Hepatocellular Carcinoma and Comprehensive Therapeutic Strategies	137
Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2	136
Cardiovascular Manifestations of COVID-19 Infection	136
Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer	135
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer	133
Polyamines: Small Amines with Large Effects on Plant Abiotic Stress Tolerance	132
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations	127
Extracellular ATP: A Feasible Target for Cancer Therapy	125
COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Barrier Relevance	122
The Role of Gut Microbiota Biomodulators on Mucosal Immunity and Intestinal Inflammation	121
Insights into the Interactions among Roots, Rhizosphere, and Rhizobacteria for Improving Plant Growth and Tolerance to Abiotic Stresses: A Review	120
The Roles of Cancer Stem Cells and Therapy Resistance in Colorectal Carcinoma	120
The RHO Family GTPases: Mechanisms of Regulation and Signaling	120
Lung Tumor Cell-Derived Exosomes Promote M2 Macrophage Polarization	118
Mechanisms Regulating Muscle Regeneration: Insights into the Interrelated and Time-Dependent Phases of Tissue Healing	117
Immune Infiltrates in Breast Cancer: Recent Updates and Clinical Implications	116
Effects of Salinity Stress on Chloroplast Structure and Function	115
Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy	111
GSK-3 and Tau: A Key Duet in Alzheimer’s Disease	110
Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils’ but Impaired Monocytes’ and Dendritic Cells’ Responsiveness	110
CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer	109
The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders	108
Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy	107
A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?	107
Necroptosis in Immuno-Oncology and Cancer Immunotherapy	106
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer	106
The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization	104
CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate	102
Chronic Diabetic Wounds and Their Treatment with Skin Substitutes	102
The Role of PPARs in Disease	102
Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control	102
The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases	101
Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical Applications	100
Future Directions in the Treatment of Osteosarcoma	100

The Role of Mitochondria in Oocyte Maturation	100
Mitochondria in Health and Diseases	99
Perivascular Inflammation in Pulmonary Arterial Hypertension	99
Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story	98
Hedgehog Signaling and Truncated GLI1 in Cancer	98
Molecular and Hormonal Mechanisms Regulating Fleshy Fruit Ripening	98
Cell Death and Inflammation: The Role of Mitochondria in Health and Disease	97
DNA Damage: From Threat to Treatment	97
Inflammatory Chemokines in Atherosclerosis	96
Regulation of TNF-Induced Osteoclast Differentiation	96
Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis	95
The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging	95
The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance	94
Neuroprotective Natural Products for Alzheimer’s Disease	94
γδ T Cells: The Ideal Tool for Cancer Immunotherapy	93
A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ	92
Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation	92
ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer	92
Macrophage Activation Markers, CD163 and CD206, in Acute-on-Chronic Liver Failure	91
Top Notch Targeting Strategies in Cancer: A Detailed Overview of Recent Insights and Current Perspectives	90
Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases	88
Role of EGFR in the Nervous System	88
Biostimulants for the Regulation of Reactive Oxygen Species Metabolism in Plants under Abiotic Stress	88
The Role of Th17 Response in COVID-19	88
Matrix Metalloproteinases as Potential Biomarkers and Therapeutic Targets in Liver Diseases	88
Spermine: Its Emerging Role in Regulating Drought Stress Responses in Plants	87
Microglia Phenotypes in Aging and Neurodegenerative Diseases	86
Beyond Activation: Characterizing Microglial Functional Phenotypes	86
Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression	86
Targeting Cancer Associated Fibroblasts in Liver Fibrosis and Liver Cancer Using Nanocarriers	86
Transient Receptor Potential Canonical (TRPC) Channels: Then and Now	85
Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling	84
A Review on Notch Signaling and Colorectal Cancer	84
Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases	84
Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health	84
SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response	84
Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold	84
Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis	83
Myeloid Cells in Glioblastoma Microenvironment	83
Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling	83
Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection	83
Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO	82
Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial Treatments, and New Developments	82
Calcium Signaling Regulates Autophagy and Apoptosis	81
Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer	81
Macrophage Modification Strategies for Efficient Cell Therapy	80
Neuron-Astrocyte Interactions in Parkinson’s Disease	80
Biosynthesis and Functions of Very-Long-Chain Fatty Acids in the Responses of Plants to Abiotic and Biotic Stresses	80
Pathogenesis of Endometriosis: The Origin of Pain and Subfertility	80
ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients	80
Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review	80
Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study	79
Retinoic Acid and Its Derivatives in Skin	79
Identifying the Therapeutic Significance of Mesenchymal Stem Cells	79
Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease	78
Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?	78
Hepatitis B Virus Entry into Cells	78
The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma	78
Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation	77
Vascular Endothelial Cells: Heterogeneity and Targeting Approaches	77
Interconnections between Inflammageing and Immunosenescence during Ageing	76
Molecular Markers and Targets in Melanoma	76
Cardiac Fibrosis and Fibroblasts	76
Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease	76
Experimental Models of Sarcopenia: Bridging Molecular Mechanism and Therapeutic Strategy	75
Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma	75
Neurofibromin Structure, Functions and Regulation	75
Metabolome Changes in Cerebral Ischemia	75
Vascular Dysfunction in Preeclampsia	75
Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications	75
Molecular Mechanisms of mtDNA-Mediated Inflammation	75
Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma	75
Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut	74
Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future	74
The Roles of Ubiquitin in Mediating Autophagy	73
Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease	73
Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis	73
Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements	72
Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects	71
Neuron-Glia Interactions in Neurodevelopmental Disorders	71

PPAR Beta/Delta and the Hallmarks of Cancer	71
Obesity as a Risk Factor for Severe COVID-19 and Complications: A Review	71
Targeting Angiopoietin in Retinal Vascular Diseases: A Literature Review and Summary of Clinical Trials Involving Faricimab	71
The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and Antibodies	71
Enhancing Salt Tolerance of Plants: From Metabolic Reprogramming to Exogenous Chemical Treatments and Molecular Approaches	71
Metabolomics in Diabetes and Diabetic Complications: Insights from Epidemiological Studies	71
Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity	70
An Insight into GPCR and G-Proteins as Cancer Drivers	70
The Role of Oxidative Stress in Atherosclerosis	70
Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders	70
IGFBP-3/IGFBP-3 Receptor System as an Anti-Tumor and Anti-Metastatic Signaling in Cancer	70
Aprotinin Inhibits SARS-CoV-2 Replication	70
GBA Variants and Parkinson Disease: Mechanisms and Treatments	69
Recent Advances in Understanding the Pathogenesis of Rheumatoid Arthritis: New Treatment Strategies	69
The Emerging Role of the Lysosome in Parkinson’s Disease	69
Extracellular Vesicles under Oxidative Stress Conditions: Biological Properties and Physiological Roles	69
Adipose Tissue-Derived Mesenchymal Stem Cells	68
Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications	68
An Immediate and Long-Term Complication of COVID-19 May Be Type 2 Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and Exploration of Possible Mechanisms	68
The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration	67
Role of Human Mesenchymal Stem Cells in Regenerative Therapy	67
Advances in Understanding of the Role of Lipid Metabolism in Aging	67
Properties and Functions of Fibroblasts and Myofibroblasts in Myocardial Infarction	67
Leukocytes, Systemic Inflammation and Immunopathology in Acute-on-Chronic Liver Failure	66
Extracellular Vesicles as Delivery Vehicles of Specific Cellular Cargo	66
Comparative Study between Exogenously Applied Plant Growth Hormones versus Metabolites of Microbial Endophytes as Plant Growth-Promoting for Phaseolus vulgaris L.	66
Glycosylation of Cancer Extracellular Vesicles: Capture Strategies, Functional Roles and Potential Clinical Applications	66
Annexin A2 in Inflammation and Host Defense	66
Significance of NETs Formation in COVID-19	66
Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line	66
The Role of Hyaluronic Acid in Cartilage Boundary Lubrication	66
Regeneration or Repair? The Role of Alveolar Epithelial Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF)	66
Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells	66
The Role of HO-1 and Its Crosstalk with Oxidative Stress in Cancer Cell Survival	66
The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation	66
Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery	65
High Mobility Group Box-1 and Blood–Brain Barrier Disruption	65
Role of Exosomal miRNAs and the Tumor Microenvironment in Drug Resistance	65
Vascularization Strategies in Bone Tissue Engineering	65
Targeting Inflammatory Pathways in Cardiovascular Disease: The Inflammasome, Interleukin-1, Interleukin-6 and Beyond	65
Emerging Role of cAMP/AMPK Signaling	65
Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology	65
SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway	64
Regulation of the Actin Cytoskeleton in Podocytes	64
The Influence of Gut Dysbiosis in the Pathogenesis and Management of Ischemic Stroke	64
Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins	64
Macrophage as a Peripheral Pain Regulator	64
BECLIN1: Protein Structure, Function and Regulation	64
Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An Updated Review	64
Artesunate Impairs Growth in Cisplatin-Resistant Bladder Cancer Cells by Cell Cycle Arrest, Apoptosis and Autophagy Induction	64
The Impact of HIV- and ART-Induced Mitochondrial Dysfunction in Cellular Senescence and Aging	64
Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration	63
TNF Production and Release from Microglia via Extracellular Vesicles: Impact on Brain Functions	63
Ubiquitination-Proteasome System (UPS) and Autophagy Two Main Protein Degradation Machineries in Response to Cell Stress	63
Schwann Cell Role in Selectivity of Nerve Regeneration	63
Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene Expression	63
NAC Transcription Factor Family Regulation of Fruit Ripening and Quality: A Review	62
Anti-VEGF-Resistant Retinal Diseases: A Review of the Latest Treatment Options	62
Is There a Role for Immunotherapy in Prostate Cancer?	62
The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention	62
Sex-Specific Differences in Glioblastoma	62
Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection	62
Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review	61
Multifunctional Role of S100 Protein Family in the Immune System: An Update	61
Mitochondrial Ca2+ Signaling in Health, Disease and Therapy	61
Diet-Induced Models of Non-Alcoholic Fatty Liver Disease: Food for Thought on Sugar, Fat, and Cholesterol	60
Peroxisome Metabolism in Cancer	60
Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance	60
The Interplay between Glioblastoma and Its Microenvironment	60
Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key	60
MiRNA Profiling in Plasma Neural-Derived Small Extracellular Vesicles from Patients with Alzheimer’s Disease	60
Canonical and Noncanonical Autophagy as Potential Targets for COVID-19	60
Ocular Neurodegenerative Diseases: Interconnection between Retina and Cortical Areas	60
NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes	60
Role of Mitochondria in Cancer Stem Cell Resistance	60
Involvement of Actin and Actin-Binding Proteins in Carcinogenesis	60
Dapagliflozin Restores Impaired Autophagy and Suppresses Inflammation in High Glucose-Treated HK-2 Cells	59
Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes	59
Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways	59
The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration	59
Hyaluronic Acid Biomaterials for Central Nervous System Regenerative Medicine	59
AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review	58
Macrophage-Mediated Inflammation in Skin Wound Healing	58
Iron Metabolism in the Tumor Microenvironment—Implications for Anti-Cancer Immune Response	58
Nano-Enhanced Cancer Immunotherapy: Immunology Encounters Nanotechnology	58
Mesenchymal Stem Cell-Derived Secretome: A Potential Therapeutic Option for Autoimmune and Immune-Mediated Inflammatory Diseases	58
Mast Cells: A New Frontier for Cancer Immunotherapy	58
Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction	58
The Multifaceted Output of c-Jun Biological Activity: Focus at the Junction of CD8 T Cell Activation and Exhaustion	58
Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer	58
The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles	58
Role of HMGB1 in the Interplay between NETosis and Thrombosis in Ischemic Stroke: A Review	58
Characterization of Apis mellifera Gastrointestinal Microbiota and Lactic Acid Bacteria for Honeybee Protection—A Review	57
Hippo Signaling Pathway in Gliomas	57
Pathogenesis Underlying Neurological Manifestations of Long COVID Syndrome and Potential Therapeutics	57