OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Advanced Research is 66. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Transcriptomic and metabolomic profiles reveal the functions of IGF-1 c.258 A > G synonymous mutation in milk fat content	613
Applications of single-cell analysis in immunotherapy for lung cancer: Current progress, new challenges and expectations	291
A multi-omics approach reveals that lotus root polysaccharide iron ameliorates iron deficiency-induced testicular damage by activating PPARγ to promote steroid hormone synthesis	287
Defect passivation and transformation of Ti3C2Tx MXene hollow microsphere for superior electrochemical performance and sodium-ions storage	277
NRIR promotes immune escape in hepatocellular cancer by regulating IFNγ-induced PD-L1 expression	265
Genomic loci associated with leaf abscission contribute to machine picking and environmental adaptability in upland cotton (Gossypium hirsutum L.)	223
Clostridium butyricum and its metabolites regulate macrophage polarization through miR-146a to antagonize gouty arthritis	211
Autoimmune responses to myelin-associated proteins as diagnostic and prognostic biomarkers of relapsing-remitting multiple sclerosis: Associations with human herpesvirus-6 and Epstein-Barr virus react	206
Trichosanthin elicits antitumor activity via MICU3 mediated mitochondria calcium influx	196
Insights into modifiable risk factors of erectile dysfunction, a wide-angled Mendelian Randomization study	185
Digital techniques and trends for seed phenotyping using optical sensors	185
The therapeutic value of “Bile Transfer” for complications of acute pancreatitis: A retrospective clinical study	183
TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway	183
Rab32-based vesicles coordinate mitochondria and actin for spindle migration and organelle rearrangement in oocyte meiosis	165
Lactobacillus johnsonii-derived extracellular vesicles carrying GAPDH protect against ulcerative colitis through modulating macrophage polarization	163
Advancements in bone organoids: perspectives on construction methodologies and application strategies	153
Unraveling the nexus in the neuro-neoplastic progression of colorectal cancer: Potential role of β2-adrenergic receptor (β2-AR)	149
DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD	147
Transglutaminase 2 modulates inflammatory angiogenesis via vascular endothelial growth factor receptor 2 pathway in inflammatory bowel disease	142
Clinical evaluation of cell-free and cellular metagenomic next-generation sequencing of infected body fluids	131
The transcription factor PbbHLH164 is destabilized by PbRAD23C/D.1 and mediates ethylene biosynthesis during pear fruit ripening	127
OsCPK9-mediated Thr105 phosphorylation activates OsCATC to enhance drought tolerance in rice	123
Modulation of Macrophage ferroptosis under the guide of infrared thermography promotes the healing of pressure injuries	120
Functions of FGF21 and its role in cardiac hypertrophy	119
Development and clinical validation of a novel protein biomarkers-based algorithm for risk prediction and diagnosis of advanced liver fibrosis: a multi-centre study	112

Ginsenoside Rh4 inhibits colorectal cancer via the modulation of gut microbiota-mediated bile acid metabolism	107
Four distinct pathways involved in a “tug-of-war” lead to the non-linear nature of phenolic chemistry during lactic acid fermentation of fruits and vegetables	107
Optimizing therapeutic efficacy of antifungal peptides via strategic terminal amino acid modification	105
Lipidomics identified novel cholesterol-independent predictors for risk of incident coronary heart disease: Mediation of risk from diabetes and aggravation of risk by ambient air pollution	102
Adaptive bilirubin nanoscavenger alleviates pulmonary oxidative stress and inflammation for acute lung injury therapy	101
Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway	101
Rural-urban disparities in cardiovascular and other competing risk of death among cancer patients	99
Not only the top: Type I topoisomerases function in multiple tissues and organs development in plants	95
Association between dietary amino acid intake and the risk of metabolic dysfunction-associated steatotic liver disease	95
Pomegranate peel extract alleviates diabetic retinopathy by suppressing the PI3K/AKT/HIF-1α/VEGF pathway and gut microbiota modulation	94
Derivation of “Egyptian varices prediction (EVP) index”: A novel noninvasive index for diagnosing esophageal varices in HCV Patients	93
SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization	91
Molecular mechanisms of amyloid disaggregation	91
Gossypium purpurascens genome provides insight into the origin and domestication of upland cotton	90
Synergistic effect of cold gas plasma and experimental drug exposure exhibits skin cancer toxicity in vitro and in vivo	89
A micropillar array-based microfluidic chip for label-free separation of circulating tumor cells: The best micropillar geometry?	88
Value of ascitic fluid lipids in the differentiation between cirrhotic and malignant ascites	88
RNA methylation modifications in neurodegenerative diseases: Focus on their enzyme system	87
CHMP4C promotes pancreatic cancer progression by inhibiting necroptosis via the RIPK1/RIPK3/MLKL pathway	86
Redox status of the plant cell determines epigenetic modifications under abiotic stress conditions and during developmental processes	85
The NLRP3 molecule influences the therapeutic effects of mesenchymal stem cells through Glut1-mediated energy metabolic reprogramming	85
A sustainable molybdenum oxysulphide-cobalt phosphate photocatalyst for effectual solar-driven water splitting	83
Population genomics analyses reveal the role of hybridization in the rapid invasion of fall armyworm	82
Forsythiaside A alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-γ/RXR-α complex	81
Lactation duration and the risk of type 2 diabetes mellitus in parous women: A perspective on socioeconomic status disparity	80
Aroma compounds with enhanced sweet perception in tea infusions: Screening, characterization, and sweetening mechanism	79
Soybean nodulation shapes the rhizosphere microbiome to increase rapeseed yield	79
S-sulfhydration: Novel insights into the antioxidant and antiinflammation in age-related diseases	77
Epigallocatechin gallate prevents and alleviates type 2 diabetes mellitus (T2DM) through gut microbiota and multi-organ interactions in Wistar healthy rats and GK T2DM rats	76
Comprehensive multi-omics analyses expose a precision therapy strategy that targets replication stress in hepatocellular carcinoma using WEE1 inhibition	74
Computational glycosyltransferases masked deoxynivalenol toxicity and halted FHB spread in wheat grains	72
Spatial-temporal lipidomics reveals dysregulated lipid metabolism in mouse brain during Alzheimer’s disease progression	72
Full dimensional dynamic 3D convolution and point cloud in pulmonary nodule detection	71
The advent of precision nutrigeroscience in cancer: from clinic towards molecular biology	70
NCAPD3 promotes diffuse large B-cell lymphoma progression through modulating SIRT1 expression in an H3K9 monomethylation-dependent manner	70
Rationally designed BCR-ABL kinase inhibitors for improved leukemia treatment via covalent and pro-/dual-drug targeting strategies	69
The immune regulation and signaling transduction of FAM134B-mediated endoplasmic reticulum-phagy in ferroptosis of dendritic cells after sepsis	69
Enhanced tuberculosis control via leveraging dendritic cell-mediated Th1 responses in preventive and immunotherapeutic vaccine strategies	69
Human serum albumin-derived biosensor for visualizing copper(II) and hydrogen sulfide interactions in cancer cells	68
Periventricular gradient of normal-appearing white matter in normal aging and multiple neurological diseases	67
Active polymerization regions of G and S monolignols show different temporal and spatial change patterns in the multicellular space during lignification and its inhibition of the fruit flesh	66
Dynamic regulation and targeted interventions of macrophages in ischemia–reperfusion injury	66
HIF-1α inhibition by MO-2097, a novel chiral-free benzofuran targeting hnRNPA2B1	66