OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Pharmaceutical Investigation is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Nitric oxide-releasing albumin/chondroitin sulfate bioadhesive dressing for the treatment of MRSA-infected wounds	140
Effects of telmisartan and perindopril combination on hypertension and cardiovascular damage	130
Development of prediction model with machine learning in continuous twin screw granulation	73
Enhanced oral bioavailability of pranlukast by preparing amorphous solid dispersion via hot-melt extrusion	67
Early pharmacokinetic evaluation of anti-tubercular treatment as a good indicator of treatment success in pulmonary tuberculosis patients on a retreatment regimen	45
The combination of HDACi encapsulated liposomal vaccines with oncolytic peptide QR-KLU induces an immune-mediated abscopal effect for cancer immunotherapy	40
Microneedle systems for delivering nucleic acid drugs	39
Recent advances in Alzheimer’s disease pathogenesis and therapeutics from an immune perspective	37
Recent advances in 3D cell culture models in cancer drug development	36
Comprehensive review in continuous direct compression process	35
Dose-independent pharmacokinetics of loganin in rats: effect of intestinal first-pass metabolism on bioavailability	33
Biocompatible biodegradable polymeric nanocarriers in dry powder inhalers (DPIs) for pulmonary inhalation delivery	31
Prediction of the pharmacokinetics of the GLP-1 receptor agonist semaglutide in humans via a population pharmacokinetic model integrating interspecies scaling	30
uPAR-targeted senolytic delivery to enhance cancer therapy	27
Organic clay-based fast dissolving microneedles for efficient transdermal delivery of therapeutic proteins	27
Lyophilization of pharmaceuticals: an overview and practical approaches for developing the lyophilization cycle	25
Pharmacokinetic modulation of substrate drugs via the inhibition of drug-metabolizing enzymes and transporters using pharmaceutical excipients	23
Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals	22
Formulation of secretome derived from mesenchymal stem cells for inflammatory skin diseases	22
A two-step design of experiments approach to investigate the simultaneous effects of ion-pairing and chemical enhancers to improve the permeability of lornoxicam in a topical hydrogel patch	21
An approach for identifying in silico peptides against authentic metabolites: in vitro characterization of thymosin β4 metabolites	20
Evaluating the effect of cationic peptide K16ApoE against Staphylococcus epidermidis biofilms	20
Enhanced oral bioavailability of megestrol acetate via polymer-hybridized solid lipid nanoparticles using ultrasonic nebulization method	19
Effects of red ginseng extract on the pharmacokinetics and disposition of warfarin via intestinal Cyp2c11 modulation in rats	19
A comprehensive review on different approaches for tumor targeting using nanocarriers and recent developments with special focus on multifunctional approaches	19

Transferrin modified PEG–PLGA nanoparticles: highly effective notoginsenoside R1 formulations for the treatment of ulcerative colitis	18
Strategies for developing Alzheimer’s disease treatments: application of population pharmacokinetic and pharmacodynamic models	18
Gold nanoparticles prevent the establishment of severe malaria in a murine animal model	18
Preformulation and evaluation of multi-layer tablets	17
Topical nanomedicines using lipids, carbohydrates, proteins, and synthetic polymers for enhanced management of skin disorders	17
Antimicrobial strategies for topical biofilm-based wound infections: past, present, and future	16
Strategic design and clinical evaluation of a fixed-dose combination tablet comprising valsartan, amlodipine, rosuvastatin and ezetimibe for patients with hypertension and dyslipidemia	15
Development of clindamycin-loaded alginate/pectin/hyaluronic acid composite hydrogel film for the treatment of MRSA-infected wounds	15
Ultra deformable vesicles for boosting transdermal delivery of 2-arylpropionic acid class drug for management of musculoskeletal pain	15
A population pharmacokinetic model for individualized regimens of finasteride according to CYP3A5 genotype and liver function	14
Indocyanine green-loaded microspheres as a near-infrared fluorescence marker for long-term localization of tumor sites	14
Emerging trends in quantum dot-based photosensitizers for enhanced photodynamic therapy in cancer treatment	13
Polysaccharide-based platforms for nasal delivery: design, features, and perspectives	13
Development and in vitro/in vivo evaluation of a nanosponge formulation loaded with Boswellia carterii oil extracts for the enhanced anti-inflammatory activity for the management of respiratory allerg	13
Tumor extracellular vesicles carrying antitumor (KLAKLAK)2 peptide and tumor-specific antigens for improved tumor therapy	13
Advancements of hot-melt extrusion technology to address unmet patient needs and pharmaceutical quality aspects	13
Injectable hydrogel systems for local cancer therapy	12
Oral bioavailability enhancement of chrysin using a spray-dried solid dispersion formulation with sodium dodecyl sulfate and polyvinylpyrrolidone	12
Dissociation mechanics and stability of type A botulinum neurotoxin complex by means of biophysical evaluation	12
Multifunctional lipidic nanocarriers for effective therapy of glioblastoma: recent advances in stimuli-responsive, receptor and subcellular targeted approaches	11
Novel microneedle patches for transdermal delivery of AP39, a hydrogen sulphide donor, in the treatment of scenarios mimicking neurological disorders	11
Recent advancements in lipid–mRNA nanoparticles as a treatment option for cancer immunotherapy	11
Alginate-coated chitosan nanoparticles protect protein drugs from acid degradation in gastric media	11
Cationic lipid nanoparticles for nucleic acid delivery: microfluidics versus thin film hydration	11
Ophthalmic dosage forms for drug delivery to posterior segment	10
Safety of applying influenza-antigen-coated microneedles to rat skin and the antigen specific immune response in vivo	10
Integration of modern science into herbal medicine: application of pharmacokinetic-pharmacodynamic modeling in understanding nonclinical study of Cinnamomum cassia extract.	10
Development and evaluation of flurbiprofen plasters	10
Development of core–shell structured nanoparticle for sequential release of tariquidar and docetaxel to overcome multi drug-resistant cancer	10
Current trends in inhaled pharmaceuticals: challenges and opportunities in respiratory infections treatment	10
Formulation of sustained-release orodispersible film containing drug–resin complexes of donepezil hydrochloride	9
Iron oxide nanoparticles-loaded hydrogels for effective topical photothermal treatment of skin cancer	9
A review of recent advances in nanotechnology for the delivery of therapeutics in wound healing	9
The combined effects of telmisartan and ramipril on hypertension and cardiovascular injury	9
Population pharmacokinetic analysis of lornoxicam in healthy Korean males considering creatinine clearance and CYP2C9 genetic polymorphism	9
ROS-activated prodrug nano-assemblies based on cinnamaldehyde-modified paclitaxel for treating breast cancer	9
Advanced technology using supercritical fluid for particle production in pharmaceutical continuous manufacturing	9
Catalase-mimicking synthetic nano-enzymes can reduce lipopolysaccharide-induced reactive oxygen generation and promote rapid detection of hydrogen peroxide and l-cysteine	8
Nitric oxide-releasing albumin nanoclusters facilitate healing of methicillin-resistant Staphylococcus aureus-infected cutaneous wounds	8
Tricaprin as a membrane permeability regulator: sustained small hydrophilic substance release from liposomes	8
Design of experiment (DoE)-based formulation design of bepotastine sustained-release tablet and in vitro-in vivo pharmacokinetic correlation	8
Wound dressing using graphene quantum dots: a proof of concept	8
A combination formulation of TPGS micelles loaded with paclitaxel and olaparib and a pH-thermosensitive hydrogel for treating peritoneal metastasis and drug-resistant ovarian cancer	8
Exploring pharmacokinetics and herb-drug interactions of an herbal extract mixture derived from Poria cocos and Morus alba L.	7
Peptide permeation enhancers for improving oral bioavailability of macromolecules	7
Pharmacokinetics and tissue distribution of NXC736, a novel modulator for sphingosine-1 phosphate receptor 1 and 4, in rats	7
Lyotropic liquid crystalline nanoparticles for oral delivery: formulation and evaluation of sustained-released cromolyn sodium loaded cubosomes	7
Recent advances in albumin nanoparticle-based cancer therapies	7
In vivo pharmacokinetic and pharmacodynamic study of inhalable pirfenidone microparticles prepared via high-energy bead milling	7
3D-printed chitosan-pectin-sodium alginate scaffolds for post-surgical peritoneal wound dressing and sustained delivery of oxaliplatin	6

AICAR-loaded and panitumumab conjugated nanoparticles downregulate the expression of PD-L1 and enhance antitumor responses against ovarian cancer through the AMPK/STAT3 axis	6
Plasmonic nanoparticle-integrated nanofibers: advancements in nanobiotechnology for biomedical applications	6
Examining the effect of spatial distribution of disintegrant particles on tablet disintegratability	6
Regulatory and safe-use considerations related to stability after opening of nonsterile dosage forms	6
Progress and recent trends in photodynamic therapy with nanoparticles	6
Development of a patient-centric formulation of tegoprazan, a novel potassium-competitive acid blocker, using modified-release drug-coated pellets	6
Zwitterionic alginate derivative as a new delivery platform for enhanced blood circulation	5
Recent trends and perspectives of artificial intelligence-based machine learning from discovery to manufacturing in biopharmaceutical industry	5
Smart pH-responsive nanomedicines for disease therapy	5
Development of abiraterone acetate tablets with enhanced oral bioavailability	5
Dietary influences on the pharmacokinetics of antihypertensive drugs: a review of food-drug interactions	5
Developmental strategy for swellable/erodible matrix tablet of mirabegron: quality by design approach with various geometric properties and pharmacokinetic evaluation	5
Solid dispersion of mebendazole via surfactant carrier to improve oral bioavailability and in vitro anticancer efficacy	5
Extracellular vesicles as drug delivery systems in therapeutics: current strategies and future challenges	5
Evaluation of a spray-dried amorphous solid dispersion formulation of ID11916, a new molecular entity with dual inhibition mechanisms targeting the androgen receptor and phosphodiesterase type-5	5
N-Salicyloyl acidic amino acids are a promising colon-specific promoiety of riluzole against rat colitis	5
Development of a self-microemulsifying drug delivery system using a Dunnione to enhance bioavailability	5
Development of a novel apixaban-loaded solid self-emulsifying drug delivery system for oral administration: physicochemical characterization and pharmacokinetics in rats	5
Recent trends in continuous manufacturing and digitalization in pharmaceutical process development and manufacturing	5
Current perspectives of artificial oxygen carriers as red blood cell substitutes: a review of old to cutting-edge technologies using in vitro and in vivo assessments	5
Layered double hydroxide Pickering emulsion with enhanced skin penetration and photostability for psoriasis treatment	5
Applying polyvinyl alcohol to the preparation of various nanoparticles	4
Statistical design of experiment-based formulation development and optimization of 3D printed oral controlled release drug delivery with multi target product profile	4
Engineered macrophages as versatile platforms for targeted cancer immunotherapy	4
Advances in alginate encapsulation of pancreatic islets for immunoprotection in type 1 diabetes	4
Blocking Fas signaling in adipose tissue ameliorates obesity-associated inflammation, insulin resistance, and hepatosteatosis	4
Nanoparticle-integrated metal–organic frameworks: a revolution in next-generation drug delivery systems	4
Amphotericin B nanocrystals integrated with bilayer dissolving microneedles: a new strategy for transmucosal delivery of amphotericin B to improve the effectiveness of oral candidiasis therapy	4
Selected addition of ternary component at specific mixing order to tune drug-carrier adhesion for enhanced lung deposition	4
Impact of 1α,25-dihydroxyvitamin D3 on biodistribution and pharmacokinetics of L-carnitine and creatinine, organic cation/carnitine transporter 2 and organic cation transporter 2 biomarkers	4
Recent developments in dry powder inhalation (DPI) formulations for lung-targeted drug delivery	4
Development and evaluation of dexamethasone-loaded bioadhesive polymeric nanocapsules for mitigating cardiac and gastric adverse effects of free dexamethasone	4
In vivo evaluation of biodistribution and toxicity of pH-responsive strontium nanoparticles for gene delivery	4
Nanomedicine-based commercial formulations: current developments and future prospects	4
Enhanced cellular uptake of sorafenib for hepatocellular carcinoma treatment: surface-modified PLGA nanoparticles with biomimetic alterations	4
Cell membrane camouflaged nanoparticle strategy and its application in brain disease: a review	4
In vitro and in vivo evaluations of a 3-month sustained-release microsphere depot formulation of leuprolide acetate	4
Long-acting exendin-4-coated selenium nanoparticles with improved hypoglycemic activity	4
Preparation and characterization of intramuscularly long-acting celecoxib nanosuspensions for postoperative pain management	4
Intravaginal application of linezolid-infused sol-gel for prophylaxis and treatment of sexually transmitted infections	4