OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Pharmaceutical Investigation is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Advancements in Uricase formulations: overcoming therapeutic challenges in enzyme replacement therapy	117
Oligonucleotide therapeutics and their chemical modification strategies for clinical applications	96
Design of experiment (DoE)-based formulation design of bepotastine sustained-release tablet and in vitro-in vivo pharmacokinetic correlation	67
Enhanced oral bioavailability of pranlukast by preparing amorphous solid dispersion via hot-melt extrusion	55
Exploring pharmacokinetics and herb-drug interactions of an herbal extract mixture derived from Poria cocos and Morus alba L.	53
Current advances and future perspectives of fattigation technology in pharmaceutical sciences and drug delivery	41
Nitric oxide-releasing albumin nanoclusters facilitate healing of methicillin-resistant Staphylococcus aureus-infected cutaneous wounds	41
Examining the effect of spatial distribution of disintegrant particles on tablet disintegratability	37
Development of nano-immunotherapy for cancer treatment: achievements and scopes	37
Preformulation and evaluation of multi-layer tablets	36
Strategies for developing Alzheimer’s disease treatments: application of population pharmacokinetic and pharmacodynamic models	33
Recent studies on modulating hyaluronic acid-based hydrogels for controlled drug delivery	31
Erythromycin dermal delivery by MoS2 nanoflakes	28
An economically advantageous amorphous solid dispersion of the fixed combination of lopinavir and ritonavir	28
Quality by design approach to the development of transdermal patch systems and regulatory perspective	28
Tricaprin as a membrane permeability regulator: sustained small hydrophilic substance release from liposomes	27
3D-printed chitosan-pectin-sodium alginate scaffolds for post-surgical peritoneal wound dressing and sustained delivery of oxaliplatin	25
Establishment of a fexofenadine population pharmacokinetic (PK)–pharmacodynamic (PD) model and exploration of dosing regimens through simulation	22
A precise look at electrospinning parameters in fabricating the polymeric nanofibers: a review on synthetic and natural polymers	22
Fabrication of aerosol-based nanoparticles and their applications in biomedical fields	21
Tumor spheroid-based microtumor models for preclinical evaluation of anticancer nanomedicines	21
Application of continuous manufacturing for solid oral dosage forms	21
Development of clindamycin-loaded alginate/pectin/hyaluronic acid composite hydrogel film for the treatment of MRSA-infected wounds	20
pH-sensitive beads containing curcumin loaded nanostructured lipid carriers for a colon targeted oral delivery system	18
Lyotropic liquid crystalline nanoparticles for oral delivery: formulation and evaluation of sustained-released cromolyn sodium loaded cubosomes	18

Development of prediction model with machine learning in continuous twin screw granulation	18
A quality by design approach in oral extended release drug delivery systems: where we are and where we are going?	18
Wound dressing using graphene quantum dots: a proof of concept	17
Mitigating off-target distribution and enhancing cytotoxicity in breast cancer cells with alpha-ketoglutaric acid-modified Fe/Mg-CA nanoparticles	16
Nitric oxide-releasing albumin/chondroitin sulfate bioadhesive dressing for the treatment of MRSA-infected wounds	16
Peptide permeation enhancers for improving oral bioavailability of macromolecules	15
Catalase-mimicking synthetic nano-enzymes can reduce lipopolysaccharide-induced reactive oxygen generation and promote rapid detection of hydrogen peroxide and l-cysteine	15
A mechanism-based understanding of altered drug pharmacokinetics by gut microbiota	14
Progress and recent trends in photodynamic therapy with nanoparticles	14
Effects of telmisartan and perindopril combination on hypertension and cardiovascular damage	14
In vivo pharmacokinetic and pharmacodynamic study of inhalable pirfenidone microparticles prepared via high-energy bead milling	13
Layered double hydroxide Pickering emulsion with enhanced skin penetration and photostability for psoriasis treatment	13
AICAR-loaded and panitumumab conjugated nanoparticles downregulate the expression of PD-L1 and enhance antitumor responses against ovarian cancer through the AMPK/STAT3 axis	13
Development and in vitro/in vivo evaluation of a nanosponge formulation loaded with Boswellia carterii oil extracts for the enhanced anti-inflammatory activity for the management of respiratory allerg	13
Antimicrobial strategies for topical biofilm-based wound infections: past, present, and future	13
Recent advances in albumin nanoparticle-based cancer therapies	13
Ultra deformable vesicles for boosting transdermal delivery of 2-arylpropionic acid class drug for management of musculoskeletal pain	12
Transdermal fluocinolone acetonide loaded decorated hyalurosomes cellulose acetate/polycaprolactone nanofibers mitigated Freund’s adjuvant-induced rheumatoid arthritis in rats	12
A review of glucoregulatory hormones potentially applicable to the treatment of Alzheimer’s disease: mechanism and brain delivery	12
Emerging trends in quantum dot-based photosensitizers for enhanced photodynamic therapy in cancer treatment	12
Developmental strategy for swellable/erodible matrix tablet of mirabegron: quality by design approach with various geometric properties and pharmacokinetic evaluation	12
Nanomedicine approaches for medulloblastoma therapy	11
Effect of gastric residence time on the oral absorption of rebamipide sustained-release tablets in beagle dogs	11
Microneedle systems for delivering nucleic acid drugs	11
A population pharmacokinetic model for individualized regimens of finasteride according to CYP3A5 genotype and liver function	11
Multicompartmental pharmacokinetic evaluation of enavogliflozin eye drop formulation: Understanding its distribution to posterior segments	11
Layered silicate nanoparticles as a non-injectable drug delivery system for biomacromolecules	10
Recent quality by design approaches for process optimization and quality enhancement of dry powder inhalers	10
Advancements of hot-melt extrusion technology to address unmet patient needs and pharmaceutical quality aspects	10
Early pharmacokinetic evaluation of anti-tubercular treatment as a good indicator of treatment success in pulmonary tuberculosis patients on a retreatment regimen	9
Microemulsion as a promising carrier for nose to brain delivery: journey since last decade	9
Regulatory and safe-use considerations related to stability after opening of nonsterile dosage forms	9
Subcutaneous injection sites impact brain uptake of blood-brain barrier impermeable paclitaxel	9
Formulation and in vitro/in vivo characterization of a fixed-dose combination tablet of dapagliflozin and rosuvastatin	8
The effects of pro-inflammatory cytokines and glutamate on l-arginine transport in a human microglial cell line (HMC-3)	8
Tableting process-induced solid-state polymorphic transition	8
Polysaccharide-based platforms for nasal delivery: design, features, and perspectives	8
Development of a self-microemulsifying drug delivery system using a Dunnione to enhance bioavailability	8
Formulation and evaluation of ivermectin-loaded dissolving microarray patches for rosacea disease	8
Development of a patient-centric formulation of tegoprazan, a novel potassium-competitive acid blocker, using modified-release drug-coated pellets	8
Strategic design and clinical evaluation of a fixed-dose combination tablet comprising valsartan, amlodipine, rosuvastatin and ezetimibe for patients with hypertension and dyslipidemia	8
Indocyanine green-loaded microspheres as a near-infrared fluorescence marker for long-term localization of tumor sites	7
Lipid-based nanoparticles for photosensitive drug delivery systems	7
In vitro–in vivo correlation of microsphere formulations: recent advances and challenges	7
Attenuation of high-fat high-sucrose diet and CCl4-induced non-alcoholic steatohepatitis in rats by activating autophagy and SIGMAR1/GRP78/ITPR1 signaling using berberine-loaded albumin nanoparticles:	6
Pattern recognition receptors and their nano-adjuvants for cancer immunotherapy	6
Development of lipid nanoparticle formulation for intramuscular administration of mRNA vaccine against respiratory syncytial virus	6
Administration route-dependent pharmacokinetic and biopharmaceutical features of steppogenin	6
Nanomedicine-based antimicrobial peptide delivery for bacterial infections: recent advances and future prospects	6
Effects of 1α,25-dihydroxyvitamin D3 on the pharmacokinetics and biodistribution of ergothioneine, an endogenous organic cation/carnitine transporter 1 substrate, in rats	6

A comprehensive review of nanosuspension loaded microneedles: fabrication methods, applications, and recent developments	6
Exemestane encapsulated copolymers L121/F127/GL44 based mixed micelles: solubility enhancement and in vitro cytotoxicity evaluation using MCF-7 breast cancer cells	6
Pharmacokinetic aspects of the clinically used proteasome inhibitor drugs and efforts toward nanoparticulate delivery systems	6
Recent trends and perspectives of artificial intelligence-based machine learning from discovery to manufacturing in biopharmaceutical industry	6
Tumor extracellular vesicles carrying antitumor (KLAKLAK)2 peptide and tumor-specific antigens for improved tumor therapy	6
Dose-independent pharmacokinetics of loganin in rats: effect of intestinal first-pass metabolism on bioavailability	5
Biocompatible biodegradable polymeric nanocarriers in dry powder inhalers (DPIs) for pulmonary inhalation delivery	5
Quality by design approach with multivariate analysis and artificial neural network models to understand and control excipient variability	5
Enhanced therapeutic efficacy of cyclosporin A eluting hyaluronic acid contact lenses in the management of dry eye disease	5
Dissociation mechanics and stability of type A botulinum neurotoxin complex by means of biophysical evaluation	5
High payload dexamethasone palmitate-loaded solid lipid nanoparticles for enhanced anti-inflammatory effects in acute skin inflammation model	5
Recent progress in cancer immunotherapy approaches based on nanoparticle delivery devices	5
Recent advances in Alzheimer’s disease pathogenesis and therapeutics from an immune perspective	5
Active targeting via ligand-anchored pH-responsive strontium nanoparticles for efficient nucleic acid delivery into breast cancer cells	5
Development of a novel apixaban-loaded solid self-emulsifying drug delivery system for oral administration: physicochemical characterization and pharmacokinetics in rats	5
Solid dispersion of mebendazole via surfactant carrier to improve oral bioavailability and in vitro anticancer efficacy	4
Injectable hydrogel systems for local cancer therapy	4
Comprehensive review in continuous direct compression process	4
Extracellular vesicles as drug delivery systems in therapeutics: current strategies and future challenges	4
Smart pH-responsive nanomedicines for disease therapy	4
Alginate-coated chitosan nanoparticles protect protein drugs from acid degradation in gastric media	4
Recent developments in chemodrug-loaded nanomedicines and their application in combination cancer immunotherapy	4
Considerations for the design of in-use stability studies of nonsterile pharmaceutical dosage forms: a literature review	4
Development and evaluation of a digestive formulation using a microbial enzyme for treatment of dyspepsia	4
Population pharmacokinetic modeling and simulation of choline in healthy Korean subjects after oral administration of choline alfoscerate	4
Novel microneedle patches for transdermal delivery of AP39, a hydrogen sulphide donor, in the treatment of scenarios mimicking neurological disorders	4
Surface modification strategies for high-dose dry powder inhalers	4
Neuroprotective role of Origanum majorana essential oil loaded in mixed surfactants based nano emulsion against lipopolysaccharide-induced Alzheimer in mice	4
Zwitterionic alginate derivative as a new delivery platform for enhanced blood circulation	4
Synthesis, physicochemical properties, and protective effects of a novel water-soluble tetrahydrocurcumin-diglutaric acid prodrug on ethanol-induced toxicity in HepG2 cells	4
Controlled release and targeted drug delivery with poly(lactic-co-glycolic acid) nanoparticles: reviewing two decades of research	4
Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors	4
Liquid-filled hard capsule formulation of choline alfoscerate: preparation and in vitro/in vivo evaluation	4