OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmaceutical Investigation is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Nitric oxide-releasing albumin/chondroitin sulfate bioadhesive dressing for the treatment of MRSA-infected wounds	172
Effects of telmisartan and perindopril combination on hypertension and cardiovascular damage	154
Development of prediction model with machine learning in continuous twin screw granulation	88
Enhanced oral bioavailability of pranlukast by preparing amorphous solid dispersion via hot-melt extrusion	78
Early pharmacokinetic evaluation of anti-tubercular treatment as a good indicator of treatment success in pulmonary tuberculosis patients on a retreatment regimen	48
Microneedle systems for delivering nucleic acid drugs	47
Recent advances in 3D cell culture models in cancer drug development	44
The combination of HDACi encapsulated liposomal vaccines with oncolytic peptide QR-KLU induces an immune-mediated abscopal effect for cancer immunotherapy	44
Comprehensive review in continuous direct compression process	39
Biocompatible biodegradable polymeric nanocarriers in dry powder inhalers (DPIs) for pulmonary inhalation delivery	36
Recent advances in Alzheimer’s disease pathogenesis and therapeutics from an immune perspective	30
Self-amplifying ROS nanoplatform with dual responsiveness for tumor-targeted photodynamic therapy	29
Lyophilization of pharmaceuticals: an overview and practical approaches for developing the lyophilization cycle	25
uPAR-targeted senolytic delivery to enhance cancer therapy	25
Pharmacokinetic modulation of substrate drugs via the inhibition of drug-metabolizing enzymes and transporters using pharmaceutical excipients	24
Formulation of secretome derived from mesenchymal stem cells for inflammatory skin diseases	24
Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals	24
Prediction of the pharmacokinetics of the GLP-1 receptor agonist semaglutide in humans via a population pharmacokinetic model integrating interspecies scaling	24
Organic clay-based fast dissolving microneedles for efficient transdermal delivery of therapeutic proteins	24
A two-step design of experiments approach to investigate the simultaneous effects of ion-pairing and chemical enhancers to improve the permeability of lornoxicam in a topical hydrogel patch	22
Theranostic potential and safety assessment of epirubicin-loaded SPIONs/PLGA-PEG nanoparticles in rabbit	20
Enhanced oral bioavailability of megestrol acetate via polymer-hybridized solid lipid nanoparticles using ultrasonic nebulization method	19
An approach for identifying in silico peptides against authentic metabolites: in vitro characterization of thymosin β4 metabolites	19
Effects of red ginseng extract on the pharmacokinetics and disposition of warfarin via intestinal Cyp2c11 modulation in rats	19
Gold nanoparticles prevent the establishment of severe malaria in a murine animal model	19

Evaluating the effect of cationic peptide K16ApoE against Staphylococcus epidermidis biofilms	19
Transferrin modified PEG–PLGA nanoparticles: highly effective notoginsenoside R1 formulations for the treatment of ulcerative colitis	18
Meta-analysis of levamisole absorption and disposition across diverse species using a minimal physiologically-based pharmacokinetic model	17
A comprehensive review on different approaches for tumor targeting using nanocarriers and recent developments with special focus on multifunctional approaches	17
Preformulation and evaluation of multi-layer tablets	17
Strategies for developing Alzheimer’s disease treatments: application of population pharmacokinetic and pharmacodynamic models	17
A population pharmacokinetic model for individualized regimens of finasteride according to CYP3A5 genotype and liver function	16
Antimicrobial strategies for topical biofilm-based wound infections: past, present, and future	16
Indocyanine green-loaded microspheres as a near-infrared fluorescence marker for long-term localization of tumor sites	16
Topical nanomedicines using lipids, carbohydrates, proteins, and synthetic polymers for enhanced management of skin disorders	16
Emerging trends in quantum dot-based photosensitizers for enhanced photodynamic therapy in cancer treatment	15
Polysaccharide-based platforms for nasal delivery: design, features, and perspectives	15
Strategic design and clinical evaluation of a fixed-dose combination tablet comprising valsartan, amlodipine, rosuvastatin and ezetimibe for patients with hypertension and dyslipidemia	15
Ultra deformable vesicles for boosting transdermal delivery of 2-arylpropionic acid class drug for management of musculoskeletal pain	14
Development and in vitro/in vivo evaluation of a nanosponge formulation loaded with Boswellia carterii oil extracts for the enhanced anti-inflammatory activity for the management of respiratory allerg	14
Cationic lipid nanoparticles for nucleic acid delivery: microfluidics versus thin film hydration	13
Tumor extracellular vesicles carrying antitumor (KLAKLAK)2 peptide and tumor-specific antigens for improved tumor therapy	13
Oral bioavailability enhancement of chrysin using a spray-dried solid dispersion formulation with sodium dodecyl sulfate and polyvinylpyrrolidone	13
Dissociation mechanics and stability of type A botulinum neurotoxin complex by means of biophysical evaluation	13
Injectable hydrogel systems for local cancer therapy	13
Advancements of hot-melt extrusion technology to address unmet patient needs and pharmaceutical quality aspects	13
Alginate-coated chitosan nanoparticles protect protein drugs from acid degradation in gastric media	12
Multifunctional lipidic nanocarriers for effective therapy of glioblastoma: recent advances in stimuli-responsive, receptor and subcellular targeted approaches	12
Development of core–shell structured nanoparticle for sequential release of tariquidar and docetaxel to overcome multi drug-resistant cancer	12
Novel microneedle patches for transdermal delivery of AP39, a hydrogen sulphide donor, in the treatment of scenarios mimicking neurological disorders	12
Safety of applying influenza-antigen-coated microneedles to rat skin and the antigen specific immune response in vivo	11
Integration of modern science into herbal medicine: application of pharmacokinetic-pharmacodynamic modeling in understanding nonclinical study of Cinnamomum cassia extract.	11
Recent advancements in lipid–mRNA nanoparticles as a treatment option for cancer immunotherapy	11
Current trends in inhaled pharmaceuticals: challenges and opportunities in respiratory infections treatment	11
Fusion nanoparticle system of extracellular vesicles and docetaxel-loaded liposomes: an innovative therapeutic strategy to enhance anticancer efficacy	11
Development and evaluation of flurbiprofen plasters	11
A review of recent advances in nanotechnology for the delivery of therapeutics in wound healing	10
Advances in transdermal delivery systems using polysaccharide-based natural enhancers: mechanisms and clinical potential	10
Pharmacokinetic/pharmacodynamic modeling of therapeutic antibodies in oncology: current advances and future perspectives	10
ROS-activated prodrug nano-assemblies based on cinnamaldehyde-modified paclitaxel for treating breast cancer	10
Ophthalmic dosage forms for drug delivery to posterior segment	10