Frontiers of Medicine

Article	Citations
FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches	63
Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141, DDHD2, and LHFPL5	62
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice	61
Prognostic value of ultrafiltration rate variability in maintenance hemodialysis patients: a prospective cohort study	52
Revisiting China’s response to coronavirus disease 2019	48
ALKBH5 exacerbates psoriatic dermatitis in mice by promoting angiogenesis	39
Betaine: an exercise mimetics for healthy aging?	36
Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics	35
Akkermansia muciniphila PROBIO therapy promotes arginine biosynthesis and reverses reproductive impairments in polycystic ovary syndrome rats	33
The adoption of repeated measurement of variance analysis and Shapiro—Wilk test	33
Novel perspectives on the link between obesity and cancer risk: from mechanisms to clinical implications	25
Global, regional and national burden and trends of congenital musculoskeletal and limb deformities among under-5 children from 1990 to 2021: a systematic analysis for the Global Burden of Disease Stud	23
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis	23
Unusual global outbreak of monkeypox: what should we do?	22
Lactate and lactylation in tumor immunity	22
Burning lactic acid: a road to revitalizing antitumor immunity	21
Factors involved in human healthy aging: insights from longevity individuals	20
Regulations of m6A and other RNA modifications and their roles in cancer	20
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy	20
Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament	20
Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019	19
Mitochondrial-associated programmed-cell-death patterns for predicting the prognosis of non-small-cell lung cancer	19
Human pangenome: far-reaching implications in precision medicine	18
Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak in Shanghai	18
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation	17

Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death at a single Chinese center	17
FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression	17
Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation	17
Research progress on molecular mechanism and future perspectives of leonurine	16
Cytokine storm and translating IL-6 biology into effective treatments for COVID-19	16
Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives	16
The nature of cancer	16
A rare case of fulminant myocarditis complicated with thrombotic aorta occlusion and multiple thrombosis: a case report	15
Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data	15
Long-acting lenacapavir is a breakthrough for preventing HIV infection, but HIV vaccine research must continue	15
GID complex regulates the differentiation of neural stem cells by destabilizing TET2	15
Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis	15
Decreased neurotensin induces ovulatory dysfunction via the NTSR1/ERK/EGR1 axis in polycystic ovary syndrome	14
Macrophage-derived semaphorin 7A drives atherosclerosis via the integrin β1/JNK/MSR1 axis	14
Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study	14
Anti-angiogenic therapy as a beacon of hope in the battle against pulmonary NUT midline carcinoma	13
Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in Northwestern Nigeria	13
A critical perspective on patient activation through integrative healthcare counseling in oncology	13
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies	13
Insights into potential therapeutic approaches for long COVID	13
Echocardiographic Measurements in Normal Chinese Adults (EMINCA) II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography	13
Application of StrucGP in medical immunology: site-specific N-glycoproteomic analysis of macrophages	12
CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer	12
Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma	12
Risk prediction and therapeutic targets for incident pulmonary hypertension: a large-scale proteomic profiling and Mendelian randomization study	12
Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China	12
m6A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation	12
Myeloid cells: key players in tumor microenvironments	12
Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study	12
Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation	12
Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis	11
Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families	11
Heterogeneity of the tumor immune microenvironment and clinical interventions	11
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization in Chinese adults	11
Answer for questions of repeated measurements of variance analysis and distribution test of data — Authors’ reply	10
Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer	10
Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China	10
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant	10
TRIM4 modulates the ubiquitin-mediated degradation of hnRNPDL and weakens sensitivity to CDK4/6 inhibitor in ovarian cancer	10
Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic	10
A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections	9
Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke	9
Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19	9
ILKAP drives hepatocellular carcinoma progression by modulating PGAM1-mediated glycolytic reprogramming	9
Roles of different methylation modifications in cardiovascular disease	9
Advancing pediatric care before birth	9
Flavivirus-infected hosts attract more mosquitoes to bite	9
CHAF1B promotes the progression of lung squamous-cell carcinoma by inhibiting SETD7 expression	9
Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis	9
China’s biosafety/biosecurity governance: evolution, challenges, and architecture design	9

Sub-threshold depolarization differentially regulated by multiple ion channels plays a key role in initiation of baroreflex afferent neurotransmission evidenced from baroreceptor terminals to its cell	9
Innovation-driven trend shaping COVID-19 vaccine development in China	8
Cardiomyocyte-specific long noncoding RNA Trdn-as induces mitochondrial calcium overload by promoting the m6A modification of calsequestrin 2 in diabetic cardiomyopathy	8
Progress of research on the gut microbiome and its metabolite short-chain fatty acids in postmenopausal osteoporosis: a literature review	8
Facile discovery of red blood cell deformation and compromised membrane/skeleton assembly in Prader—Willi syndrome	8
Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients	7
Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis	7
Immune landscape and response to oncolytic virus-based immunotherapy	7
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway	7
RRS1 regulates proliferation, migration, and invasion of HTR-8/SVneo human trophoblasts	7
Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis	7
Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation, single-center, phase I/II clinical trial	7
Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia	7
First insights into genotype and phenotype of familial amyotrophic lateral sclerosis in Egypt: early onset and high consanguinity	7
Dihydroartemisinin increased the abundance of Akkermansia muciniphila by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy	7
Progress and challenges in RET-targeted cancer therapy	7
Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors	6
Plasma cell development-based prediction of prognosis and treatment response in individual multiple myeloma	6
BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models	6
Cellular senescence in age-related musculoskeletal diseases	6
Tonic signaling in CAR-T therapy: the lever long enough to move the planet	6
Update on Mayer—Rokitansky—Küster—Hauser syndrome	6
Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ	6
Enhancing patient activation: a controlled implementation study of an interprofessional evidence-based counseling program for complementary and integrative healthcare in cancer patients (‘CCC-Integrat	6
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions	6
Sequential development of three syndromes in a patient with m.3243A>G mutation: a case report	6
Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective	6
Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside	5
EBV-associated lymphoproliferative disease post-CAR-T cell therapy	5
lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis	5
A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors	5
Association of oral frailty and gut microbiota with hypertension: cross-sectional results in the Shika study	5
Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial	5
Perspective on strengthening dementia prevention and control system: a comprehensive framework for national health	5
CYP4F11 promotes lung cancer progression through the miR-195/ME2 pathway	5
Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma	5
lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression	5
Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial	5
Unlocking the potential of bispecific ADCs for targeted cancer therapy	5
Gallstones, cholecystectomy, and cancer risk: an observational and Mendelian randomization study	5
Metabolic biomarkers for predicting onset and severity of CAR-T therapy-induced cytokine release syndrome in multiple myeloma	5
Predictive biomarkers for immunotherapy in nasopharyngeal carcinoma: from tumor microenvironment to macroenvironment	5
lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1α–mitochondrial complex IV axis	4
Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients aged over 65 years	4
Single-cell transcriptome analyses of PBMCs reveal the immunological characteristics of individuals with phlegm-dampness constitution	4
Adenosine deaminase 2 regulates the activation of the toll-like receptor 9 in response to nucleic acids	4
Intracellular checkpoints for NK cell cancer immunotherapy	4
Recurrent eosinophilia with a novel homozygous ARPC1B mutation	4
Risk factors for mortality in neonatal ARDS: a multicenter retrospective cohort study in China	4
A specific tsRNA in serum from patients with nasopharyngeal carcinoma: 5′tiRNA-32-ValAAC-2 mediates malignance of nasopharyngeal carcinoma cells	4
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives	4
A promising new TERT activator: unraveling the molecular mechanisms behind its natural aging mitigation	4
Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn/winter 2022 COVID-19 wave in Chinese mainland	4
Current state of bioceramic bone repair materials in immune regulation: a review	4
Preclinical and clinical studies on Qin-Zhu-Liang-Xue decoction: insights from network pharmacology and implications for atopic dermatitis treatment	4
Non small cell lung cancer with SMARCA4 deficiency harboring rare EGFR mutations exhibited significant tumor response when treated with afatinib: a case report	4
Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia	4
Low dose of hydroxychloroquine is associated with reduced COVID-19 mortality: a multicenter study in China	4
Multifaceted function of B cells in tumorigenesis	4
Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panel study	3
Inhibition of cap-dependent endonuclease in influenza virus with ADC189: a pre-clinical analysis and phase I trial	3
Neurokinin-1 receptor antagonists in the current management of chemotherapy-induced nausea and vomiting	3
Plasma transthyretin is a nutritional biomarker in human morbidities	3
Incidence and risk factors of female sexual dysfunction in urban and rural China: a 4-year prospective cohort study	3
ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification	3
Identification of novel mutations in EYA3 and EFTUD2 in a family with craniofacial microsomia: evidence of digenic inheritance	3
Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions	3
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature	3
Fine-tuning cell organelle dynamics during mitosis by small GTPases	3
Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial	3
Holistic Integrative Medicine Declaration	3
Determining the biomarkers and pathogenesis of myocardial infarction combined with ankylosing spondylitis via a systems biology approach	3
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma	3
Management and operation of extra-large Fangcang hospitals: experience and lessons from containing the highly contagious SARS-CoV-2 Omicron in Shanghai, China	3
Passive antibody therapy in emerging infectious diseases	3
HOXB13 in cancer development: molecular mechanisms and clinical implications	3
Transparency and reporting characteristics of randomized controlled trials with Chinese herbal medicine formulas interventions	3
SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic	3
Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca2+ homeostasis in a murine model of HFpEF	3
ChromTR: chromosome detection in raw metaphase cell images via deformable transformers	3

ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis

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