OOIR: Observatory of International Research

Papers

(The median citation count of Frontiers of Medicine is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice	101
Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141, DDHD2, and LHFPL5	61
FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches	61
Revisiting China’s response to coronavirus disease 2019	60
ALKBH5 exacerbates psoriatic dermatitis in mice by promoting angiogenesis	51
Betaine: an exercise mimetics for healthy aging?	42
Novel perspectives on the link between obesity and cancer risk: from mechanisms to clinical implications	37
Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients	36
Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics	34
The adoption of repeated measurement of variance analysis and Shapiro—Wilk test	34
Unusual global outbreak of monkeypox: what should we do?	32
Lactate and lactylation in tumor immunity	30
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis	29
Global, regional and national burden and trends of congenital musculoskeletal and limb deformities among under-5 children from 1990 to 2021: a systematic analysis for the Global Burden of Disease Stud	29
Burning lactic acid: a road to revitalizing antitumor immunity	26
Regulations of m6A and other RNA modifications and their roles in cancer	22
Factors involved in human healthy aging: insights from longevity individuals	22
Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak in Shanghai	22
Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament	21
Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019	20
Mitochondrial-associated programmed-cell-death patterns for predicting the prognosis of non-small-cell lung cancer	20
Human pangenome: far-reaching implications in precision medicine	19
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy	19
Penetrance estimation of PRRT2 variants in paroxysmal kinesigenic dyskinesia and infantile convulsions	19
Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation	17

Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death at a single Chinese center	17
The nature of cancer	17
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation	17
FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression	17
GID complex regulates the differentiation of neural stem cells by destabilizing TET2	16
Research progress on molecular mechanism and future perspectives of leonurine	16
Cytokine storm and translating IL-6 biology into effective treatments for COVID-19	16
Long-acting lenacapavir is a breakthrough for preventing HIV infection, but HIV vaccine research must continue	15
Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data	15
Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis	15
Decreased neurotensin induces ovulatory dysfunction via the NTSR1/ERK/EGR1 axis in polycystic ovary syndrome	15
Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives	15
Emerging immunological strategies: recent advances and future directions	14
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies	14
Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study	14
Anti-angiogenic therapy as a beacon of hope in the battle against pulmonary NUT midline carcinoma	13
Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in Northwestern Nigeria	13
Application of StrucGP in medical immunology: site-specific N-glycoproteomic analysis of macrophages	13
A critical perspective on patient activation through integrative healthcare counseling in oncology	13
CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer	13
Echocardiographic Measurements in Normal Chinese Adults (EMINCA) II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography	13
Insights into potential therapeutic approaches for long COVID	12
Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair cells	12
Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma	12
Myeloid cells: key players in tumor microenvironments	12
Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China	12
Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study	12
m6A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation	12
Heterogeneity of the tumor immune microenvironment and clinical interventions	12
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant	11
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization in Chinese adults	11
Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis	11
A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections	11
Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer	11
Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation	11
Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic	11
Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families	11
TRIM4 modulates the ubiquitin-mediated degradation of hnRNPDL and weakens sensitivity to CDK4/6 inhibitor in ovarian cancer	10
Answer for questions of repeated measurements of variance analysis and distribution test of data — Authors’ reply	10
CHAF1B promotes the progression of lung squamous-cell carcinoma by inhibiting SETD7 expression	10
Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke	10
Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis	9
Flavivirus-infected hosts attract more mosquitoes to bite	9
Advancing pediatric care before birth	9
Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China	9
Cardiomyocyte-specific long noncoding RNA Trdn-as induces mitochondrial calcium overload by promoting the m6A modification of calsequestrin 2 in diabetic cardiomyopathy	9
Hyperglycemic memory in diabetic cardiomyopathy	9
Astrocytes in depression and Alzheimer’s disease	9
Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19	8
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway	8

Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia	8
Facile discovery of red blood cell deformation and compromised membrane/skeleton assembly in Prader—Willi syndrome	8
Dihydroartemisinin increased the abundance of Akkermansia muciniphila by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy	8
Progress of research on the gut microbiome and its metabolite short-chain fatty acids in postmenopausal osteoporosis: a literature review	8
China’s biosafety/biosecurity governance: evolution, challenges, and architecture design	8
First insights into genotype and phenotype of familial amyotrophic lateral sclerosis in Egypt: early onset and high consanguinity	8
Innovation-driven trend shaping COVID-19 vaccine development in China	8
Immune landscape and response to oncolytic virus-based immunotherapy	8
Progress and challenges in RET-targeted cancer therapy	7
Tonic signaling in CAR-T therapy: the lever long enough to move the planet	7
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions	7
Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective	7
Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation, single-center, phase I/II clinical trial	7
Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients	7
RRS1 regulates proliferation, migration, and invasion of HTR-8/SVneo human trophoblasts	7
Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors	7
Update on Mayer—Rokitansky—Küster—Hauser syndrome	7
Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis	7
Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ	7
Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis	7
Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma	6
Perspective on strengthening dementia prevention and control system: a comprehensive framework for national health	6
BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models	6
Enhancing patient activation: a controlled implementation study of an interprofessional evidence-based counseling program for complementary and integrative healthcare in cancer patients (‘CCC-Integrat	6
Unlocking the potential of bispecific ADCs for targeted cancer therapy	6
A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors	6
Interactions between remote ischemic conditioning and post-stroke sleep regulation	6
18F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma	6
EBV-associated lymphoproliferative disease post-CAR-T cell therapy	6
Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial	6
Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial	6
Cellular senescence in age-related musculoskeletal diseases	6
lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis	5
Preclinical and clinical studies on Qin-Zhu-Liang-Xue decoction: insights from network pharmacology and implications for atopic dermatitis treatment	5
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives	5
Predictive biomarkers for immunotherapy in nasopharyngeal carcinoma: from tumor microenvironment to macroenvironment	5
Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside	5
lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1α–mitochondrial complex IV axis	5
Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients aged over 65 years	5
Adenosine deaminase 2 regulates the activation of the toll-like receptor 9 in response to nucleic acids	5
lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression	5
Gallstones, cholecystectomy, and cancer risk: an observational and Mendelian randomization study	5
Single-cell transcriptome analyses of PBMCs reveal the immunological characteristics of individuals with phlegm-dampness constitution	5
Non small cell lung cancer with SMARCA4 deficiency harboring rare EGFR mutations exhibited significant tumor response when treated with afatinib: a case report	5
Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia	5
A promising new TERT activator: unraveling the molecular mechanisms behind its natural aging mitigation	4
Multifaceted function of B cells in tumorigenesis	4
Low dose of hydroxychloroquine is associated with reduced COVID-19 mortality: a multicenter study in China	4
ChromTR: chromosome detection in raw metaphase cell images via deformable transformers	4
Management and operation of extra-large Fangcang hospitals: experience and lessons from containing the highly contagious SARS-CoV-2 Omicron in Shanghai, China	4
Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn/winter 2022 COVID-19 wave in Chinese mainland	4
Recurrent eosinophilia with a novel homozygous ARPC1B mutation	4
Identification of novel mutations in EYA3 and EFTUD2 in a family with craniofacial microsomia: evidence of digenic inheritance	4
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma	4
Intracellular checkpoints for NK cell cancer immunotherapy	4
Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panel study	4
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis	4
ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification	4
Incidence and risk factors of female sexual dysfunction in urban and rural China: a 4-year prospective cohort study	3
Neurokinin-1 receptor antagonists in the current management of chemotherapy-induced nausea and vomiting	3
Passive antibody therapy in emerging infectious diseases	3
HOXB13 in cancer development: molecular mechanisms and clinical implications	3
Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca2+ homeostasis in a murine model of HFpEF	3
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies	3
Developing a polygenic risk score for pelvic organ prolapse: a combined risk assessment approach in Chinese women	3
Plasma transthyretin is a nutritional biomarker in human morbidities	3
Determining the biomarkers and pathogenesis of myocardial infarction combined with ankylosing spondylitis via a systems biology approach	3
Holistic Integrative Medicine Declaration	3
Fine-tuning cell organelle dynamics during mitosis by small GTPases	3
Association of TRMT2B gene variants with juvenile amyotrophic lateral sclerosis	3
Artificial intelligence methods available for cancer research	3
Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target	3
SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic	3
Decellularized extracellular matrix mediates tissue construction and regeneration	3
Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions	3
Inhibition of cap-dependent endonuclease in influenza virus with ADC189: a pre-clinical analysis and phase I trial	3
Transparency and reporting characteristics of randomized controlled trials with Chinese herbal medicine formulas interventions	3
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature	3
Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial	3