Frontiers of Medicine

Article	Citations
Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panel study	75
Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis	58
Long-term correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human heavy chain and the rat light chain	55
Recurrent eosinophilia with a novel homozygous ARPC1B mutation	55
Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study	50
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions	47
ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification	43
Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors	42
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma	41
A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency anemia in China	39
Rare tumors: a blue ocean of investigation	38
COVID-19: why not learn from the past?	36
Assessment of HER2 status in extramammary Paget disease and its implication for disitamab vedotin, a novel humanized anti-HER2 antibody-drug conjugate therapy	28
Novel mutation c.1210-3C > G in cis with a poly-T tract of 5T affects CFTR mRNA splicing in a Chinese patient with cystic fibrosis	28
Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in embryonic and adult mammalian heart	28
Management and operation of extra-large Fangcang hospitals: experience and lessons from containing the highly contagious SARS-CoV-2 Omicron in Shanghai, China	27
FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches	26
Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in Northwestern Nigeria	25
Identification of novel mutations in EYA3 and EFTUD2 in a family with craniofacial microsomia: evidence of digenic inheritance	23
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice	22
Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141, DDHD2, and LHFPL5	20
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma	20
Echocardiographic Measurements in Normal Chinese Adults (EMINCA) II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography	19
Erratum to: Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis	18
A review of the safety and efficacy of current COVID-19 vaccines	18

ChromTR: chromosome detection in raw metaphase cell images via deformable transformers	17
PAK5-mediated PKM2 phosphorylation is critical for anaerobic glycolysis in endometriosis	16
Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke	15
Phase separation in cGAS-STING signaling	14
Renin-angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID-19 among patients with/without hypertension	14
Base editors: development and applications in biomedicine	14
Passive antibody therapy in emerging infectious diseases	13
Application of StrucGP in medical immunology: site-specific N-glycoproteomic analysis of macrophages	13
Early-life famine exposure, adulthood obesity patterns, and risk of low-energy fracture	13
PathogenTrack and Yeskit: tools for identifying intracellular pathogens from single-cell RNA-sequencing datasets as illustrated by application to COVID-19	12
Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis	12
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis	12
Mechanism of insulin resistance in obesity: a role of ATP	12
Update on Mayer—Rokitansky—Küster—Hauser syndrome	12
GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cell carcinoma	11
Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia	11
Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity	11
Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors	11
Tonic signaling in CAR-T therapy: the lever long enough to move the planet	11
CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer	11
HOXB13 in cancer development: molecular mechanisms and clinical implications	11
Antibiotic resistome of Salmonella typhi: molecular determinants for the emergence of drug resistance	11
Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections	10
Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ	10
Acupuncture is ineffective for chronic low back pain? A critical analysis and rethinking	10
Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions	10
Heterogeneity of the tumor immune microenvironment and clinical interventions	10
Interactions between remote ischemic conditioning and post-stroke sleep regulation	10
A novel variant in the GJB6 gene in a large Chinese family with a unique phenotype of Clouston syndrome	9
CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?	9
Prevalence of antifolate drug resistance markers in Plasmodium vivax in China	9
Canonical and noncanonical NOTCH signaling in the nongenetic resistance of cancer: distinct and concerted control	9
Incidence and risk factors of female sexual dysfunction in urban and rural China: a 4-year prospective cohort study	9
Update of cellular senescence in kidney fibrosis: from mechanism to potential interventions	9
Myeloid cells: key players in tumor microenvironments	9
Enhancing patient activation: a controlled implementation study of an interprofessional evidence-based counseling program for complementary and integrative healthcare in cancer patients (‘CCC-Integrat	9
Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods	8
Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling	8
Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats	8
Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients	8
Disparities in 36 cancers across 185 countries: secondary analysis of global cancer statistics	8
BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models	8
Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective	7
SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic	7
Inhibition of cap-dependent endonuclease in influenza virus with ADC189: a pre-clinical analysis and phase I trial	7
Intracellular concentration of ADA2 is a marker for monocyte differentiation and activation	7
J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study in China	7
Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular carcinoma	7
Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic challenges	6
Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies	6

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma	6
Plasma transthyretin is a nutritional biomarker in human morbidities	6
Acquired immune thrombotic thrombocytopenic purpura (TTP) associated with inactivated COVID-19 vaccine CoronaVac	6
Revisiting China’s response to coronavirus disease 2019	6
The adoption of repeated measurement of variance analysis and Shapiro—Wilk test	6
Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation	6
Unusual global outbreak of monkeypox: what should we do?	6
R158Q and G212S, novel pathogenic compound heterozygous variants in SLC12A3 of Gitelman syndrome	6
Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China	6
Epigenetic modifiers: catalytic or noncatalytic, that is the question	5
Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial	5
Holistic Integrative Medicine Declaration	5
Prevalence of anemia of varying severity, geographic variations, and association with metabolic factors among women of reproductive age in China: a nationwide, population-based study	5
m6A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation	4
Integrated analysis of gut microbiome and host immune responses in COVID-19	4
Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca2+ homeostasis in a murine model of HFpEF	4
Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair cells	4
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization in Chinese adults	4
A distinct “repair” role of regulatory T cells in fracture healing	4
Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer	4
A new perspective in pyroptosis: lifting the veil on GSDMA activation	4
Advancements in the research of the structure, function, and disease-related roles of ARMC5	4
Biosensor-based assay of exosome biomarker for early diagnosis of cancer	4
Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis	4
Progress on early diagnosing Alzheimer’s disease	4
EEG-controlled functional electrical stimulation rehabilitation for chronic stroke: system design and clinical application	4
18F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma	4
Evaluation of ICUs and weight of quality control indicators: an exploratory study based on Chinese ICU quality data from 2015 to 2020	4
Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families	4
Decellularized extracellular matrix mediates tissue construction and regeneration	4
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis	4
Novel perspectives on the link between obesity and cancer risk: from mechanisms to clinical implications	4
Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics	4
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies	4
Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamous non-small-cell lung cancer: a retrospective analysis	4
Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor T therapy	4
The critical importance of epigenetics in autoimmune-related skin diseases	4
H. sinensis mycelium inhibits epithelial-mesenchymal transition by inactivating the midkine pathway in pulmonary fibrosis	3
EBV-associated lymphoproliferative disease post-CAR-T cell therapy	3
Association of TRMT2B gene variants with juvenile amyotrophic lateral sclerosis	3
Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic	3
Transparency and reporting characteristics of randomized controlled trials with Chinese herbal medicine formulas interventions	3
Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial	3
Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial	3
Unlocking the potential of bispecific ADCs for targeted cancer therapy	3
Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study	3
Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults	3
SARS-CoV-2 variants, immune escape, and countermeasures	3
Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak in Shanghai	3
Artificial intelligence methods available for cancer research	3
Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament	3
Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution	3
Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant	3
Regulations of m6A and other RNA modifications and their roles in cancer	3
Clinical applications of neurolinguistics in neurosurgery	3
Discovery and repurposing of artemisinin	3
Fine-tuning cell organelle dynamics during mitosis by small GTPases	3
Factors involved in human healthy aging: insights from longevity individuals	3
Hybrid deep learning model for risk prediction of fracture in patients with diabetes and osteoporosis	3
Penetrance estimation of PRRT2 variants in paroxysmal kinesigenic dyskinesia and infantile convulsions	3
Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019	3
Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis	3
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature	3
Effects and mechanisms of acupuncture on women related health	3
Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis	3
Erratum to: Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy in NSCLC	3
Burning lactic acid: a road to revitalizing antitumor immunity	3
Does the outcome of acupuncture differ according to the location of sham needling points in acupuncture trials for migraine? A systematic review and network meta-analysis	3
Mitochondrial-associated programmed-cell-death patterns for predicting the prognosis of non-small-cell lung cancer	3
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy	3
Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside	2
FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression	2
Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup analysis of a randomized phase 2 study (ALTER1202)	2
The novel anthraquinone compound Kanglexin prevents endothelial-to-mesenchymal transition in atherosclerosis by activating FGFR1 and suppressing integrin β1/TGFβ signaling	2
lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis	2
Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression	2
Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)	2
CHAF1B promotes the progression of lung squamous-cell carcinoma by inhibiting SETD7 expression	2
TRIM4 modulates the ubiquitin-mediated degradation of hnRNPDL and weakens sensitivity to CDK4/6 inhibitor in ovarian cancer	2
Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death at a single Chinese center	2

The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant	2
A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections	2
Trajectory of COVID-19 response and management strategy in China: scientific rationale driven strategy adjustments	2
Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese Children’s Cancer Group-ALL-2015	2
Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China	2
Discovery of small molecule degraders for modulating cell cycle	2
IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential thrombocythemia	2
The development and benefits of metformin in various diseases	2
NETO2 promotes melanoma progression via activation of the Ca2+/CaMKII signaling pathway	2
Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease	2
Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target	2
Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor in pancreatic cancer	2
Gallstones, cholecystectomy, and cancer risk: an observational and Mendelian randomization study	2
Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai Integration Model (SIM)	2
Answer for questions of repeated measurements of variance analysis and distribution test of data — Authors’ reply	2
A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors	2