Journal of Pharmaceutical Analysis

Article	Citations
Publisher’s Note	118
Crebanine protects against ovariectomy-induced bone loss by targeting Sirt1 to interfere with NF-κB acetylation and ROS activity	114
Automated closed-cell production platform solves dilemma of industrial-scale manufacturing for mesenchymal stromal cell-based therapy	108
Editorial Board	108
Editorial Board	107
Editorial Board	103
Editorial Board	97
Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation	96
Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy	92
1,8-cineole ameliorates colon injury by downregulating macrophage M1 polarization via inhibiting the HSP90-NLRP3-SGT1 complex	92
Breaking barriers: MS-BDF tools in the quality control of insect-derived traditional Chinese medicine	89
Exploring the impact of the liver-intestine-brain axis on brain function in non-alcoholic fatty liver disease	84
Metabolic difference of potentially toxic components from Psoraleae Fructus and Euodiae Fructus in Sishen formula by different compatibilities and physiologies	76
Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids	72
Analysis of GC × GC fingerprints from medicinal materials using a novel contour detection algorithm: A case of Curcuma wenyujin	68
Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy	66
Deep learning-based drug screening for the discovery of potential therapeutic agents for Alzheimer's disease	65
Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine metabolism for insomnia treatment	65
Evaluation of the metabolism of PEP06, an endostatin-RGDRGD 30-amino-acid polypeptide and a promising novel drug for targeting tumor cells	64
Targeted metabolomics reveals the aberrant energy status in diabetic peripheral neuropathy and the neuroprotective mechanism of traditional Chinese medicine JinMaiTong	63
Rapid authentication of different herbal medicines by heating online extraction electrospray ionization mass spectrometry	58
Melatonin enhances the efficacy of anti-PD-L1 by improving hypoxia in residual tumors after insufficient radiofrequency ablation	56
Recent trends of machine learning applied to multi-source data of medicinal plants	56
Targeted screening and profiling of massive components of colistimethate sodium by two-dimensional-liquid chromatography-mass spectrometry based on self-constructed compound database	55
Distinct types of regulated cell death in atherosclerosis	55

Effect of cholesterol on distribution, cell uptake, and protein corona of lipid microspheres at sites of cardiovascular inflammatory injury	53
Fingerprint-enhanced hierarchical molecular graph neural networks for property prediction	51
Ultrasensitive quantification of trace amines based on N-phosphorylation labeling chip 2D LC-QQQ/MS	50
Generation of SARS-CoV-2 dual-target candidate inhibitors through 3D equivariant conditional generative neural networks	50
Validation of breast cancer as a risk factor for anxiety and depression: Insights from Mendelian randomization analysis	50
Understanding the mechanistic and therapeutic perspectives on cytokines and chemokines in acute high-altitude illness syndromes	48
Multiple roles of arsenic compounds in phase separation and membraneless organelles formation determine their therapeutic efficacy in tumors	47
Targeted bile acids metabolomics in cholesterol gallbladder polyps and gallstones: From analytical method development towards application to clinical samples	47
Novel hormone therapies for advanced prostate cancer: Understanding and countering drug resistance	45
Natural product-based radiopharmaceuticals: Focus on curcumin and its analogs, flavonoids, and marine peptides	45
Time-course monitoring of in vitro biotransformation reaction via solid-phase microextraction-ambient mass spectrometry approaches	45
An LC-MS/MS method for simultaneous analysis of the cystic fibrosis therapeutic drugs colistin, ivacaftor and ciprofloxacin	44
Potential therapeutic effects and applications of Eucommiae Folium in secondary hypertension	42
Apatinib and gamabufotalin co-loaded lipid/Prussian blue nanoparticles for synergistic therapy to gastric cancer with metastasis	42
Adaptive multi-view learning method for enhanced drug repurposing using chemical-induced transcriptional profiles, knowledge graphs, and large language models	41
HIF-1α in CD4+ T cells drives gout pathogenesis via metabolic reprogramming and Th17 differentiation	41
Repurposing drugs for the human dopamine transporter through WHALES descriptors-based virtual screening and bioactivity evaluation	40
Dexamethasone palmitate-loaded sHDL nanodiscs: Enhanced efficacy and safety in allergic conjunctivitis	40
Supramolecular prodrug inspiried by the Rhizoma Coptidis-Fructus Mume herbal pair alleviated inflammatory diseases by inhibiting pyroptosis	40
Advances and challenges in using nirmatrelvir and its derivatives against SARS-CoV-2 infection	39
Raman analysis of lipids in cells: Current applications and future prospects	36
Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system	36
A review on the screening methods for the discovery of natural antimicrobial peptides	35
A chiral metal-organic framework {(HQA)(ZnCl2)(2.5H2O)}n for the enantioseparation of chiral amino acids and drugs	35
Modern approaches for detection of volatile organic compounds in metabolic studies focusing on pathogenic bacteria: Current state of the art	34
USP50-mediated NLRP3 deubiquitination enhances NLRP3 inflammasome activation to suppress HCC metastasis	34
Extracellular vesicles in anti-tumor drug resistance: Mechanisms and therapeutic prospects	33
A high-throughput measurement of critical micelle concentrations based on absolute aggregation-caused quenching probes	33
Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity	32
Diffusion-based generative drug-like molecular editing with chemical natural language	32
Ferroptosis and retinal ganglion cell death in glaucoma: Mechanisms and therapeutic approaches	32
Solid-phase microextraction of endogenous metabolites from intact tissue validated using a Biocrates standard reference method kit	31
MEOX2 promotes glioma growth and temozolomide chemoresistance	31
Application of lipidomics in the study of traditional Chinese medicine	31
Lactate metabolism and lactylation: Therapeutic and pre-clinical implications in neovascularization in peripheral artery disease	30
Editorial Board	30
Editorial Board	30
Virulence arresting drugs discovery by strategies targeting bacterial virulence: mainly focusing on quorum-sensing interference and biofilm inhibition	29
Novel Bioactive Peptides Targeting Keap1-Nrf2 Interaction for Combating UVA-Induced Skin Aging: Computational Discovery and Experimental Validation	29
Metabolomic fingerprinting of porcine lung tissue during pre-clinical prolonged ex vivo lung perfusion using in vivo SPME coupled with LC-HRMS	29
Unveiling the ‘Eating Poison’ of Polygala tenuifolia xylem: Mood changes and myocardial injury	29
CA IX-targeted Ag2S quantum dots bioprobe for NIR-II imaging-guided hypoxia tumor chemo-photothermal therapy	29
A highly sensitive bio-barcode immunoassay for multi-residue detection of organophosphate pesticides based on fluorescence anti-quenching	28
Polarity-regulated derivatization-assisted LC-MS method for amino-containing metabolites profiling in gastric cancer	28
Nylon 6-cellulose composite hosted in a hypodermic needle: Biofluid extraction and analysis by ambient mass spectrometry in a single device	28
Tumor-targeting intravenous lipid emulsion of paclitaxel: Characteristics, stability, toxicity, and toxicokinetics	28
Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC	27
Drug repurposing against coronavirus disease 2019 (COVID-19): A review	27
Fabrication of edge-curled petals-like covalent organic frameworks and their properties for extracting indole alkaloids from complex biological samples	27
Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells	27

Latest surface plasmon resonance advances for G protein-coupled receptors	27
An Fe–Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy	26
Integrating High-resolution Bioassay Profiling with Affinity-based Ligand Fishing for Unveiling Galloylated Derivatives as Novel Catechol-O-methyltransferase Inhibitors in Paeonia lactiflora Pall.	26
The “depict” strategy for discovering new compounds in complex matrices: Lycibarbarspermidines as a case	26
Single-cell RNA sequencing reveals the changes of the pulmonary immune environment in rat after Siegesbeckia orientalis L. treatment	26
Recent advances in mass spectrometry-based bioanalytical methods for endogenous biomarkers analysis in transporter-mediated drug-drug interactions	26
Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis	25
DTLCDR: A target-based multimodal fusion deep learning framework for cancer drug response prediction	25
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats	25
Mild photothermal therapy for cancer cell modulation: A transformative approach to regulate cancer cell phenotype and enhance therapeutic outcomes	25
In situ synthesis of a spherical covalent organic framework as a stationary phase for capillary electrochromatography	24
Enhancing metformin-induced tumor metabolism destruction by glucose oxidase for triple-combination therapy	23
Ginkgolic acid inhibits CD8+ T cell activation and induces ferroptosis by lactate dehydrogenase A to exert immunosuppressive effect	23
Tailoring a traditional Chinese medicine prescription for complex diseases: A novel multi-targets-directed gradient weighting strategy	23
Lycium barbarum's diabetes secrets: A comprehensive review of cellular, molecular, and epigenetic targets with immune modulation and microbiome influence	23
Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia	23
Dihydroartemisinin ameliorates innate inflammatory response induced by Streptococcus suis-derived muramidase-released protein via inactivation of TLR4-dependent NF-κB signaling	22
Intrinsic gallium-68 labeling of nanoclays for in vivo tracking	22
GB7 acetate, a galbulimima alkaloid from Galbulimima belgraveana, possesses anticancer effects in colorectal cancer cells	22
Sensitive detection of microRNAs using polyadenine-mediated fluorescent spherical nucleic acids and a microfluidic electrokinetic signal amplification chip	22
Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application	22
Geometry-based BERT: An experimentally validated deep learning model for molecular property prediction in drug discovery	22
Influence of traditional Chinese medicines on the in vivo metabolism of lopinavir/ritonavir based on UHPLC-MS/MS analysis	22
Preparation of Fe3O4@SW-MIL-101-NH2 for selective pre-concentration of chlorogenic acid metabolites in rat plasma, urine, and feces samples	22
CeFe nanofibrous carbon nanozyme integrated with smartphone for the point-of-care testing of norfloxacin in water	22
Natural products for the treatment of age-related macular degeneration: New insights focusing on mitochondrial quality control and cGAS/STING pathway	22
DMMIC derivatization-assisted liquid chromatography-mass spectrometry method for metabolite profiling of the glutathione anabolic pathway in esophageal cancer tissues and cells	22
Small-molecule probes based on natural products: Elucidation of drug-target mechanisms in stroke	21
Hypothalamic lipidomics reveals that AMPK-FA metabolism mediates the energy-balancing effect of the four typical “hot” herbs on hypothyroidism	21
Characterization of preclinical radio ADME properties of ARV-471 for predicting human PK using PBPK modeling	21
Integrating gas-chromatographical analyses with nuclear-magnetic-resonance spectroscopy to elucidate anti-microbial profile of oleoresins isolated from Rauvolfia serpentina seeds by supercritical–(CO2	21
In silico prediction of pKa values using explainable deep learning methods	21
Unlocking the potential of atractylenolide II: mitigating non-alcoholic fatty liver disease through farnesoid X receptor-endoplasmic reticulum stress interplay	21
A Scd1-mediated metabolic alteration participates in liver responses to low-dose bavachin	21
Targeting angiogenesis in diabetic wound healing: New insight from chemical architecture to functional outcomes	21
Novel assays for quality evaluation of XueBiJing: Quality variability of a Chinese herbal injection for sepsis management	21
Neuroinflammation attenuation effects by celastrol and PDIA3 in the amygdala, hippocampus and dorsal raphe nucleus of obese mice	21
A review of research methods for elucidating the microstructure of pharmaceutical preparations	20
Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases	20
Intestinal anti-inflammatory drug targets as potential modifiers of cardiovascular disease risk	20
A gene set enrichment analysis for cancer hallmarks	20
17β-Estradiol, through activating the G protein-coupled estrogen receptor, exacerbates the complication of benign prostatic hyperplasia in type 2 diabetes mellitus patients by inducing prostate prolif	20
Advancing drug safety and mitigating health concerns: High-resolution mass spectrometry in the levothyroxine case study	20
Editorial Board	20
Absolute bioavailability, dose proportionality, and tissue distribution of rotundic acid in rats based on validated LC-QqQ-MS/MS method	20
Development and validation of a static multiple light scattering (SMLS) method for real-time colloidal stability assessment in nanoparticle formulations	20
Applications and safety of gold nanoparticles as therapeutic devices in clinical trials	20
A promising strategy of brain targeted delivery for the treatment of Parkinson's disease: Cyclodextrin supramolecular inclusion complex based thermosensitive gel	19
Silent or low expression of blaTEM and blaSHV suggests potential for targeted proteomics in clinical detection of β-lactamase-related antimicrobial resistance	19
YTE-17 inhibits colonic carcinogenesis by resetting antitumor immune response via Wnt5a/JNK mediated metabolic signaling	19
Editorial Board	19
β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects	19
Polyphyllin VII promotes hepatic stellate cell ferroptosis via the HIC1/CX3CL1/GPX4 axis	19
WITHDRAWN: Targeted protein degradation: A promising approach for cancer treatment	19
Screen of FDA-approved drug library identifies vitamin K as anti-ferroptotic drug for osteoarthritis therapy through Gas6	19
Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease	19
A comprehensive review on herbal approaches for treatment of urinary tract infections: Scope and challenges	19
Metabolomics: A useful tool for ischemic stroke research	18
Corrigendum to “Active components of Dengzhan Shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca2+/CaMKII pathway” [J. Pharm.	18
Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: Integration of herbal medicine, enzyme engineering, and nanotechnology	18
Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis	18
Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis	18
Blocking the adverse outcome pathway of skin sensitization through a N-acetyl cysteine and lysine-loaded hydrogel	17
Modifying current thin-film microextraction (TFME) solutions for analyzing prohibited substances: Evaluating new coatings using liquid chromatography	17
Strategy for cysteine-targeting covalent inhibitors screening using in-house database based LC-MS/MS and drug repurposing	17
Discovery of E0199: A novel compound targeting both peripheral NaV and KV7 channels to alleviate neuropathic pain	17
A novel exploration of COL11A1's role in regulating myeloid-derived suppressor cell activation within the colon cancer microenvironment	17
Albumin-bound kynurenic acid is an appropriate endogenous biomarker for assessment of the renal tubular OATs-MRP4 channel	16
Inosine: A broad-spectrum anti-inflammatory against SARS-CoV-2 infection-induced acute lung injury via suppressing TBK1 phosphorylation	16
Exploring TGFBR3 in disease pathogenesis: Mechanisms, clinical implications, and pharmacological modulation	16
Tumor-associated macrophages in hepatocellular carcinoma: Cellular plasticity and therapy resistance in crosstalk	16
Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions	16
Cuproptosis tracker: Visualizing organelle dynamics with a dual-targeted fluorescent probe	16
Editorial Board	16
In Vivo Analysis Techniques for Antibody Drug: Recent Advances and Methodological Insights	15
Cocktail hepatocarcinoma therapy by a super-assembled nano-pill targeting XPO1 and ATR synergistically	15
TCMKD: From ancient wisdom to modern insights-A comprehensive platform for traditional Chinese medicine knowledge discovery	15
Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice	15
Integrated spatial metabolomics and transcriptomics decipher the hepatoprotection mechanisms of wedelolactone and demethylwedelolactone on non-alcoholic fatty liver disease	15
Non-targeted and chiral amino acid metabolomics of colon cancer: Revealing novel chiral biomarkers and metabolic pathways	15

High-strength antiswelling adhesive achieves both hemostasis and wound healing	15
Screening of glycan biomarkers for early detection of colorectal cancer based on novel isotope labeling relative quantitative method	15
Screening strategies for quorum sensing inhibitors in combating bacterial infections	15
Discovery of pulmonary fibrosis inhibitor targeting TGF-β RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy	15
Zebrafish as a vertebrate model for high-throughput drug toxicity screening: Mechanisms, novel techniques, and future perspectives	15
Investigating ischemia and reperfusion-induced organ damage in severe cardiac arrest: A comprehensive proteomics perspective	15
Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis	15
Caenorhabditis elegans deep lipidome profiling by using integrative mass spectrometry acquisitions reveals significantly altered lipid networks	15
Breaking the boundaries of affinity selection-mass spectrometry: From ligand screening to target-ligand interaction insights	15
Targeted nano-drug delivery systems for tumor immunotherapy	14
Chemical analysis, antihyperglycemic properties and enzyme inhibition of Opuntia dillenii (Ker Gawl.) Haw.: A detailed analysis of pulp and peel extracts	14
Elemene as a binding stabilizer of microRNA-145-5p suppresses the growth of non-small cell lung cancer	14
Mechanisms and therapeutic potential of YTHDF readers: linking epitranscriptomics to cancer	14
Integrating explainable deep learning with multi-omics for screening progressive diagnostic biomarkers of hepatocellular carcinoma covering the “inflammation-cancer” transformation	14
A high throughput strategy for traditional Chinese medicine active compound screening based on Raman spectroscopy	14
Capillary electrophoresis methods for impurity profiling of drugs: A review of the past decade	14
Drug delivery system of curcumin to the lungs based on poly(3-alloxyloxy-1,2-propylene succinate)-sebacic acid copolymers	14
A promising leap in early screening for chronic kidney disease: The smartphone-integrated handheld automated biochemical analyzer	14
Emodin is a novel phosphatidylethanolamine anabolism inhibitor that reprograms lipid metabolism to overcome 5-fluorouracil resistance in colorectal cancer	14
Combining transformer and 3DCNN models to achieve co-design of structures and sequences of antibodies in a diffusional manner	14
Identification of forsythoside A from Forsythia fruit for alleviating MAFLD via metabolic remodeling and IL-17 pathway regulation	14
Dissection of triple-negative breast cancer microenvironment and identification of potential therapeutic drugs using single-cell RNA sequencing analysis	14
Recent advances in nanomaterial-based optical biosensors and their biomedical and biopharmaceutical applications	13
Editorial Board	13
Editorial Board	13
Rational design of a novel specific fluorescent substrate for monitoring hUGT1A4 activity and its application in identification of selective inhibitors	13
Lipid metabolism analysis in esophageal cancer and associated drug discovery	13
Predicting cardiotoxicity in drug development: A deep learning approach	13
Editorial Board	13
Characterization of natural peptides in Pheretima by integrating proteogenomics and label-free peptidomics	13
Unraveling pyrrolizidine alkaloid-induced liver damage with an integrative spatial lipidomics framework	13
Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS	13
Fragmentation stability and retention time-shift obtained by LC-MS/MS to distinguish sialylated N-glycan linkage isomers in therapeutic glycoproteins	13
New uses of halofuginone to treat cancer	13
18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs	12
Current developments of bioanalytical sample preparation techniques in pharmaceuticals	12
Effects of polyol excipient stability during storage and use on the quality of biopharmaceutical formulations	12
Novel insights into histone lysine methyltransferases in cancer therapy: From epigenetic regulation to selective drugs	12
Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer	12
Gut dysbiosis aggravates cognitive deficits, amyloid pathology and lipid metabolism dysregulation in a transgenic mouse model of Alzheimer's disease	12
Development of a novel multi-functional integrated bioconjugate effectively targeting K-Ras mutant pancreatic cancer	12
Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling	12
Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA	12
On-site rapid detection of multiple pesticide residues in tea leaves by lateral flow immunoassay	12
Single-cell and spatially resolved omics: Advances and limitations	12
Comment on: “Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors”	12