Journal of Pharmaceutical Analysis

Article	Citations
Editorial Board	174
Automated closed-cell production platform solves dilemma of industrial-scale manufacturing for mesenchymal stromal cell-based therapy	97
Editorial Board	95
Publisher’s Note	87
Analysis of GC × GC fingerprints from medicinal materials using a novel contour detection algorithm: A case of Curcuma wenyujin	79
Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation	79
Exploring the Impact of the Liver-Intestine-Brain Axis on Brain Function in Non-Alcoholic Fatty Liver Disease	77
Targeted metabolomics reveals the aberrant energy status in diabetic peripheral neuropathy and the neuroprotective mechanism of traditional Chinese medicine JinMaiTong	77
Editorial Board	74
Breaking Barriers: MS-BDF Tools in the Quality Control of Insect-derived Traditional Chinese Medicine	74
Evaluation of the metabolism of PEP06, an endostatin-RGDRGD 30-amino-acid polypeptide and a promising novel drug for targeting tumor cells	69
Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy	67
Editorial Board	59
Deep learning-based drug screening for the discovery of potential therapeutic agents for Alzheimer's disease	57
Melatonin enhances the efficacy of anti-PD-L1 by improving hypoxia in residual tumors after insufficient radiofrequency ablation	55
Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine metabolism for insomnia treatment	55
Simulation of the oxidative metabolization pattern of netupitant, an NK1 receptor antagonist, by electrochemistry coupled to mass spectrometry	55
Rapid authentication of different herbal medicines by heating online extraction electrospray ionization mass spectrometry	51
Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids	50
Recent trends of machine learning applied to multi-source data of medicinal plants	50
1,8-cineole ameliorates colon injury by downregulating macrophage M1 polarization via inhibiting the HSP90-NLRP3-SGT1 complex	48
Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy	48
Fingerprint-enhanced hierarchical molecular graph neural networks for property prediction	45
Generation of SARS-CoV-2 dual-target candidate inhibitors through 3D equivariant conditional generative neural networks	44
Time-course monitoring of in vitro biotransformation reaction via solid-phase microextraction-ambient mass spectrometry approaches	43

A high-throughput measurement of critical micelle concentrations based on absolute aggregation-caused quenching probes	42
Advances and challenges in using nirmatrelvir and its derivatives against SARS-CoV-2 infection	42
Potential therapeutic effects and applications of Eucommiae Folium in secondary hypertension	42
Novel hormone therapies for advanced prostate cancer: understanding and countering drug resistance	41
Adaptive multi-view learning method for enhanced drug repurposing using chemical-induced transcriptional profiles, knowledge graphs, and large language models	41
Dispersive liquid-liquid microextraction, an effective tool for the determination of synthetic cannabinoids in oral fluid by liquid chromatography–tandem mass spectrometry	38
Targeted bile acids metabolomics in cholesterol gallbladder polyps and gallstones: From analytical method development towards application to clinical samples	38
Ultrasensitive quantification of trace amines based on N-phosphorylation labeling chip 2D LC-QQQ/MS	38
Targeted screening and profiling of massive components of colistimethate sodium by two-dimensional-liquid chromatography-mass spectrometry based on self-constructed compound database	37
Multiple roles of arsenic compounds in phase separation and membraneless organelles formation determine their therapeutic efficacy in tumors	37
Supramolecular prodrug inspiried by the Rhizoma Coptidis-Fructus Mume herbal pair alleviated inflammatory diseases by inhibiting pyroptosis	36
Understanding the Mechanistic and Therapeutic Perspectives on Cytokines and Chemokines in Acute High-Altitude Illness Syndromes	34
Effect of cholesterol on distribution, cell uptake, and protein corona of lipid microspheres at sites of cardiovascular inflammatory injury	34
Diffusion-based generative drug-like molecular editing with chemical natural language	34
Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system	33
Extracellular vesicles in anti-tumor drug resistance: Mechanisms and therapeutic prospects	33
Dexamethasone palmitate-loaded sHDL nanodiscs: Enhanced efficacy and safety in allergic conjunctivitis	33
Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity	32
Raman analysis of lipids in cells: Current applications and future prospects	31
A chiral metal-organic framework {(HQA)(ZnCl2)(2.5H2O)}n for the enantioseparation of chiral amino acids and drugs	31
Apatinib and gamabufotalin co-loaded lipid/Prussian blue nanoparticles for synergistic therapy to gastric cancer with metastasis	31
An LC-MS/MS method for simultaneous analysis of the cystic fibrosis therapeutic drugs colistin, ivacaftor and ciprofloxacin	31
A review on the screening methods for the discovery of natural antimicrobial peptides	31
Drug repurposing against coronavirus disease 2019 (COVID-19): A review	30
Printability–A key issue in extrusion-based bioprinting	30
Editorial Board	30
Modern approaches for detection of volatile organic compounds in metabolic studies focusing on pathogenic bacteria: Current state of the art	30
Editorial Board	30
Natural product-based radiopharmaceuticals: Focus on curcumin and its analogs, flavonoids, and marine peptides	30
CA IX-targeted Ag2S quantum dots bioprobe for NIR-II imaging-guided hypoxia tumor chemo-photothermal therapy	27
Solid-phase microextraction of endogenous metabolites from intact tissue validated using a Biocrates standard reference method kit	27
Application of lipidomics in the study of traditional Chinese medicine	27
A highly sensitive bio-barcode immunoassay for multi-residue detection of organophosphate pesticides based on fluorescence anti-quenching	26
Fabrication of edge-curled petals-like covalent organic frameworks and their properties for extracting indole alkaloids from complex biological samples	26
Polarity-regulated derivatization-assisted LC-MS method for amino-containing metabolites profiling in gastric cancer	26
Virulence arresting drugs discovery by strategies targeting bacterial virulence: mainly focusing on quorum-sensing interference and biofilm inhibition	25
Nylon 6-cellulose composite hosted in a hypodermic needle: Biofluid extraction and analysis by ambient mass spectrometry in a single device	25
Metabolomic fingerprinting of porcine lung tissue during pre-clinical prolonged ex vivo lung perfusion using in vivo SPME coupled with LC-HRMS	24
Comparative permeability of three saikosaponins and corresponding saikogenins in Caco-2 model by a validated UHPLC-MS/MS method	24
MEOX2 promotes glioma growth and temozolomide chemoresistance	24
Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells	24
Tumor-targeting intravenous lipid emulsion of paclitaxel: Characteristics, stability, toxicity, and toxicokinetics	23
Single-cell RNA sequencing reveals the changes of the pulmonary immune environment in rat after Siegesbeckia orientalis L. treatment	22
Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application	22
CeFe nanofibrous carbon nanozyme integrated with smartphone for the point-of-care testing of norfloxacin in water	22
Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC	22
Natural products for the treatment of age-related macular degeneration: new insights focusing on mitochondrial quality control and cGAS/STING pathway	22
The “depict” strategy for discovering new compounds in complex matrices: Lycibarbarspermidines as a case	22
In situ synthesis of a spherical covalent organic framework as a stationary phase for capillary electrochromatography	22
Lycium Barbarum's Diabetes Secrets: A Comprehensive Review of Cellular, Molecular, and Epigenetic Targets with Immune Modulation and Microbiome Influence	21

Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia	21
Ginkgolic acid inhibits CD8+ T cell activation and induces ferroptosis by lactate dehydrogenase A to exert immunosuppressive effect	21
Mild photothermal therapy for cancer cell modulation: A transformative approach to regulate cancer cell phenotype and enhance therapeutic outcomes	21
Recent advances in mass spectrometry-based bioanalytical methods for endogenous biomarkers analysis in transporter-mediated drug-drug interactions	21
DTLCDR: A target-based multimodal fusion deep learning framework for cancer drug response prediction	20
An Fe–Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy	20
Dihydroartemisinin ameliorates innate inflammatory response induced by Streptococcus suis-derived muramidase-released protein via inactivation of TLR4-dependent NF-κB signaling	20
Tailoring a traditional Chinese medicine prescription for complex diseases: A novel multi-targets-directed gradient weighting strategy	20
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats	20
Enhancing metformin-induced tumor metabolism destruction by glucose oxidase for triple-combination therapy	20
Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis	19
Characterization of preclinical radio ADME properties of ARV-471 for predicting human PK using PBPK modeling	19
Neuroinflammation attenuation effects by celastrol and PDIA3 in the amygdala, hippocampus and dorsal raphe nucleus of obese mice	19
Unlocking the potential of atractylenolide II: mitigating non-alcoholic fatty liver disease through farnesoid X receptor-endoplasmic reticulum stress interplay	19
Identification and quantification of the bioactive components in Osmanthus fragrans roots by HPLC-MS/MS	19
Intrinsic gallium-68 labeling of nanoclays for in vivo tracking	19
Sensitive detection of microRNAs using polyadenine-mediated fluorescent spherical nucleic acids and a microfluidic electrokinetic signal amplification chip	19
Influence of traditional Chinese medicines on the in vivo metabolism of lopinavir/ritonavir based on UHPLC-MS/MS analysis	19
In Silico Prediction of pKa Values Using Explainable Deep Learning Methods	19
GB7 acetate, a galbulimima alkaloid from Galbulimima belgraveana, possesses anticancer effects in colorectal cancer cells	19
Preparation of Fe3O4@SW-MIL-101-NH2 for selective pre-concentration of chlorogenic acid metabolites in rat plasma, urine, and feces samples	19
Matrix-assisted laser desorption ionization mass spectrometry based quantitative analysis of cordycepin from Cordyceps militaris	19
Editorial Board	18
DMMIC derivatization-assisted liquid chromatography-mass spectrometry method for metabolite profiling of the glutathione anabolic pathway in esophageal cancer tissues and cells	18
A gene set enrichment analysis for the cancer hallmarks	18
Applications and safety of gold nanoparticles as therapeutic devices in clinical trials	18
Novel assays for quality evaluation of XueBiJing: Quality variability of a Chinese herbal injection for sepsis management	18
Small-molecule probes based on natural products: Elucidation of drug-target mechanisms in stroke	18
A Scd1-mediated metabolic alteration participates in liver responses to low-dose bavachin	18
17β-Estradiol, through activating the G protein-coupled estrogen receptor, exacerbates the complication of benign prostatic hyperplasia in type 2 diabetes mellitus patients by inducing prostate prolif	18
Hypothalamic lipidomics reveals that AMPK-FA metabolism mediates the energy-balancing effect of the four typical “hot” herbs on hypothyroidism	18
Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota	18
Polyphyllin VII promotes hepatic stellate cell ferroptosis via the HIC1/CX3CL1/GPX4 axis	17
Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease	17
A review of research methods for elucidating the microstructure of pharmaceutical preparations	17
Editorial Board	17
Silent or low expression of blaTEM and blaSHV suggests potential for targeted proteomics in clinical detection of β-lactamase-related antimicrobial resistance	17
Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases	16
Plasma-metabolite-based machine learning is a promising diagnostic approach for esophageal squamous cell carcinoma investigation	16
Screen of FDA-approved drug library identifies Vitamin K as anti-ferroptotic drug for osteoarthritis therapy through Gas6	16
Metabolomics: A useful tool for ischemic stroke research	16
Absolute bioavailability, dose proportionality, and tissue distribution of rotundic acid in rats based on validated LC-QqQ-MS/MS method	16
Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis	16
Advancing drug safety and mitigating health concerns: High-resolution mass spectrometry in the levothyroxine case study	16
YTE-17 inhibits colonic carcinogenesis by resetting antitumor immune response via Wnt5a/JNK mediated metabolic signaling	16
A promising strategy of brain targeted delivery for the treatment of Parkinson's disease: Cyclodextrin supramolecular inclusion complex based thermosensitive gel	16
Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis	16
WITHDRAWN: Targeted protein degradation: A promising approach for cancer treatment	16
β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects	16
High-strength antiswelling adhesive achieves both hemostasis and wound healing	15
Discovery of E0199: A novel compound targeting both peripheral NaV and KV7 channels to alleviate neuropathic pain	15
Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: Integration of herbal medicine, enzyme engineering, and nanotechnology	15
Screening of glycan biomarkers for early detection of colorectal cancer based on novel isotope labeling relative quantitative method	15
Editorial Board	15
Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice	15
Inosine: A broad-spectrum anti-inflammatory against SARS-CoV-2 infection-induced acute lung injury via suppressing TBK1 phosphorylation	14
Investigating ischemia and reperfusion-induced organ damage in severe cardiac arrest: A comprehensive proteomics perspective	14
Blocking the adverse outcome pathway of skin sensitization through a N-acetyl cysteine and lysine-loaded hydrogel	14
Caenorhabditis elegans deep lipidome profiling by using integrative mass spectrometry acquisitions reveals significantly altered lipid networks	14
Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions	14
Albumin-bound kynurenic acid is an appropriate endogenous biomarker for assessment of the renal tubular OATs-MRP4 channel	14
Modifying current thin-film microextraction (TFME) solutions for analyzing prohibited substances: Evaluating new coatings using liquid chromatography	14
Strategy for cysteine-targeting covalent inhibitors screening using in-house database based LC-MS/MS and drug repurposing	14
TCMKD: From ancient wisdom to modern insights-A comprehensive platform for traditional Chinese medicine knowledge discovery	14
Cocktail hepatocarcinoma therapy by a super-assembled nano-pill targeting XPO1 and ATR synergistically	14
Zebrafish as a Vertebrate Model for High-Throughput Drug Toxicity Screening: Mechanisms, Novel Techniques, and Future Perspectives	14
Corrigendum to “Active components of Dengzhan Shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca2+/CaMKII pathway” [J. Pharm.	14
Discovery of pulmonary fibrosis inhibitor targeting TGF-β RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy	14
In Vivo Analysis Techniques for Antibody Drug: Recent Advances and Methodological Insights	14
A novel exploration of COL11A1's role in regulating myeloid-derived suppressor cell activation within the colon cancer microenvironment	13
Screening strategies for quorum sensing inhibitors in combating bacterial infections	13
Portable and automated analyzer for rapid and high precision in vitro dissolution of drugs	13
Integrated spatial metabolomics and transcriptomics decipher the hepatoprotection mechanisms of wedelolactone and demethylwedelolactone on non-alcoholic fatty liver disease	13
Identification of forsythoside A from Forsythia fruit for alleviating MAFLD via metabolic remodeling and IL-17 pathway regulation	13
Lipid metabolism analysis in esophageal cancer and associated drug discovery	13
Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis	13
Combining transformer and 3DCNN models to achieve co-design of structures and sequences of antibodies in a diffusional manner	13
Integrating explainable deep learning with multi-omics for screening progressive diagnostic biomarkers of hepatocellular carcinoma covering the “inflammation-cancer” transformation	13
Dissection of triple-negative breast cancer microenvironment and identification of potential therapeutic drugs using single-cell RNA sequencing analysis	13
Capillary electrophoresis methods for impurity profiling of drugs: A review of the past decade	13

Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence	13
Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS	13
Chemical Analysis, Antihyperglycemic Properties and Enzyme Inhibition of Opuntia dillenii (Ker Gawl.) Haw: A Detailed Analysis of Pulp and Peel Extracts	13
Elemene as a binding stabilizer of microRNA-145-5p suppresses the growth of non-small cell lung cancer	13
Editorial Board	13
Fragmentation stability and retention time-shift obtained by LC-MS/MS to distinguish sialylated N-glycan linkage isomers in therapeutic glycoproteins	12
Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal	12
Comment on: “Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors”	12
Predicting cardiotoxicity in drug development: A deep learning approach	12
Editorial Board	12
Characterization of natural peptides in Pheretima by integrating proteogenomics and label-free peptidomics	12
Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA	11
Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer	11
Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling	11
Application of microfluidic technology based on surface-enhanced Raman scattering in cancer biomarker detection: A review	11
On-site rapid detection of multiple pesticide residues in tea leaves by lateral flow immunoassay	11
18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs	11
Software-aided efficient identification of the components of compound formulae and their metabolites in rats by UHPLC/IM-QTOF-MS and an in-house high-definition MS2 library: Sishen formula as a case	11
Single-cell and spatially resolved omics: Advances and limitations	11
Development of a novel multi-functional integrated bioconjugate effectively targeting K-Ras mutant pancreatic cancer	11
Gut dysbiosis aggravates cognitive deficits, amyloid pathology and lipid metabolism dysregulation in a transgenic mouse model of Alzheimer's disease	11
New uses of halofuginone to treat cancer	11
Current developments of bioanalytical sample preparation techniques in pharmaceuticals	11
Novel insights into histone lysine methyltransferases in cancer therapy: From epigenetic regulation to selective drugs	11
Effects of polyol excipient stability during storage and use on the quality of biopharmaceutical formulations	11