Journal of Pharmaceutical Analysis

Article	Citations
Editorial Board	201
Editorial Board	107
Publisher’s Note	106
Exploring the impact of the liver-intestine-brain axis on brain function in non-alcoholic fatty liver disease	98
Editorial Board	95
Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy	93
Editorial Board	89
Simulation of the oxidative metabolization pattern of netupitant, an NK1 receptor antagonist, by electrochemistry coupled to mass spectrometry	81
Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine metabolism for insomnia treatment	81
Automated closed-cell production platform solves dilemma of industrial-scale manufacturing for mesenchymal stromal cell-based therapy	79
Analysis of GC × GC fingerprints from medicinal materials using a novel contour detection algorithm: A case of Curcuma wenyujin	75
Melatonin enhances the efficacy of anti-PD-L1 by improving hypoxia in residual tumors after insufficient radiofrequency ablation	75
Rapid authentication of different herbal medicines by heating online extraction electrospray ionization mass spectrometry	75
Breaking barriers: MS-BDF tools in the quality control of insect-derived traditional Chinese medicine	66
Crebanine protects against ovariectomy-induced bone loss by targeting Sirt1 to interfere with NF-κB acetylation and ROS activity	64
Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids	64
Deep learning-based drug screening for the discovery of potential therapeutic agents for Alzheimer's disease	63
Evaluation of the metabolism of PEP06, an endostatin-RGDRGD 30-amino-acid polypeptide and a promising novel drug for targeting tumor cells	63
Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation	63
Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy	61
Recent trends of machine learning applied to multi-source data of medicinal plants	59
1,8-cineole ameliorates colon injury by downregulating macrophage M1 polarization via inhibiting the HSP90-NLRP3-SGT1 complex	53
Targeted metabolomics reveals the aberrant energy status in diabetic peripheral neuropathy and the neuroprotective mechanism of traditional Chinese medicine JinMaiTong	53
USP50-mediated NLRP3 deubiquitination enhances NLRP3 inflammasome activation to suppress HCC metastasis	50
Advances and challenges in using nirmatrelvir and its derivatives against SARS-CoV-2 infection	49

A high-throughput measurement of critical micelle concentrations based on absolute aggregation-caused quenching probes	48
Raman analysis of lipids in cells: Current applications and future prospects	48
Fingerprint-enhanced hierarchical molecular graph neural networks for property prediction	47
Effect of cholesterol on distribution, cell uptake, and protein corona of lipid microspheres at sites of cardiovascular inflammatory injury	47
Multiple roles of arsenic compounds in phase separation and membraneless organelles formation determine their therapeutic efficacy in tumors	46
Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system	44
Novel hormone therapies for advanced prostate cancer: understanding and countering drug resistance	44
Diffusion-based generative drug-like molecular editing with chemical natural language	44
Potential therapeutic effects and applications of Eucommiae Folium in secondary hypertension	43
Supramolecular prodrug inspiried by the Rhizoma Coptidis-Fructus Mume herbal pair alleviated inflammatory diseases by inhibiting pyroptosis	42
Targeted screening and profiling of massive components of colistimethate sodium by two-dimensional-liquid chromatography-mass spectrometry based on self-constructed compound database	41
Understanding the Mechanistic and Therapeutic Perspectives on Cytokines and Chemokines in Acute High-Altitude Illness Syndromes	40
Dexamethasone palmitate-loaded sHDL nanodiscs: Enhanced efficacy and safety in allergic conjunctivitis	39
A chiral metal-organic framework {(HQA)(ZnCl2)(2.5H2O)}n for the enantioseparation of chiral amino acids and drugs	39
Adaptive multi-view learning method for enhanced drug repurposing using chemical-induced transcriptional profiles, knowledge graphs, and large language models	38
Validation of breast cancer as a risk factor for anxiety and depression: insights from mendelian randomization analysis	37
An LC-MS/MS method for simultaneous analysis of the cystic fibrosis therapeutic drugs colistin, ivacaftor and ciprofloxacin	37
Time-course monitoring of in vitro biotransformation reaction via solid-phase microextraction-ambient mass spectrometry approaches	37
Apatinib and gamabufotalin co-loaded lipid/Prussian blue nanoparticles for synergistic therapy to gastric cancer with metastasis	37
Distinct types of regulated cell death in atherosclerosis	37
Targeted bile acids metabolomics in cholesterol gallbladder polyps and gallstones: From analytical method development towards application to clinical samples	36
Ultrasensitive quantification of trace amines based on N-phosphorylation labeling chip 2D LC-QQQ/MS	36
Modern approaches for detection of volatile organic compounds in metabolic studies focusing on pathogenic bacteria: Current state of the art	35
Natural product-based radiopharmaceuticals: Focus on curcumin and its analogs, flavonoids, and marine peptides	34
Generation of SARS-CoV-2 dual-target candidate inhibitors through 3D equivariant conditional generative neural networks	33
Printability–A key issue in extrusion-based bioprinting	32
Extracellular vesicles in anti-tumor drug resistance: Mechanisms and therapeutic prospects	32
Repurposing drugs for the human dopamine transporter through WHALES descriptors-based virtual screening and bioactivity evaluation	32
Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity	31
Editorial Board	30
A review on the screening methods for the discovery of natural antimicrobial peptides	30
Application of lipidomics in the study of traditional Chinese medicine	30
Editorial Board	30
MEOX2 promotes glioma growth and temozolomide chemoresistance	29
Polarity-regulated derivatization-assisted LC-MS method for amino-containing metabolites profiling in gastric cancer	29
Drug repurposing against coronavirus disease 2019 (COVID-19): A review	28
Tumor-targeting intravenous lipid emulsion of paclitaxel: Characteristics, stability, toxicity, and toxicokinetics	28
Ferroptosis and retinal ganglion cell death in glaucoma: Mechanisms and therapeutic approaches	27
Nylon 6-cellulose composite hosted in a hypodermic needle: Biofluid extraction and analysis by ambient mass spectrometry in a single device	27
CA IX-targeted Ag2S quantum dots bioprobe for NIR-II imaging-guided hypoxia tumor chemo-photothermal therapy	27
Solid-phase microextraction of endogenous metabolites from intact tissue validated using a Biocrates standard reference method kit	26
Virulence arresting drugs discovery by strategies targeting bacterial virulence: mainly focusing on quorum-sensing interference and biofilm inhibition	26
Fabrication of edge-curled petals-like covalent organic frameworks and their properties for extracting indole alkaloids from complex biological samples	25
Latest surface plasmon resonance advances for G protein-coupled receptors	24
Metabolomic fingerprinting of porcine lung tissue during pre-clinical prolonged ex vivo lung perfusion using in vivo SPME coupled with LC-HRMS	24
Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells	24
Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC	23
Mild photothermal therapy for cancer cell modulation: A transformative approach to regulate cancer cell phenotype and enhance therapeutic outcomes	23
A highly sensitive bio-barcode immunoassay for multi-residue detection of organophosphate pesticides based on fluorescence anti-quenching	23
Single-cell RNA sequencing reveals the changes of the pulmonary immune environment in rat after Siegesbeckia orientalis L. treatment	23

An Fe–Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy	23
Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis	23
Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application	23
Tailoring a traditional Chinese medicine prescription for complex diseases: A novel multi-targets-directed gradient weighting strategy	23
Recent advances in mass spectrometry-based bioanalytical methods for endogenous biomarkers analysis in transporter-mediated drug-drug interactions	22
Lycium barbarum's diabetes secrets: A comprehensive review of cellular, molecular, and epigenetic targets with immune modulation and microbiome influence	22
In situ synthesis of a spherical covalent organic framework as a stationary phase for capillary electrochromatography	22
Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia	22
Natural products for the treatment of age-related macular degeneration: New insights focusing on mitochondrial quality control and cGAS/STING pathway	22
The “depict” strategy for discovering new compounds in complex matrices: Lycibarbarspermidines as a case	22
Ginkgolic acid inhibits CD8+ T cell activation and induces ferroptosis by lactate dehydrogenase A to exert immunosuppressive effect	22
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats	22
Enhancing metformin-induced tumor metabolism destruction by glucose oxidase for triple-combination therapy	22
Integrating Gas-Chromatographical Analyses with Nuclear-Magnetic-Resonance Spectroscopy to Elucidate Anti-microbial Profile of Oleoresins Isolated from Rauvolfia serpentina seeds by Supercritical-(CO2	21
DTLCDR: A target-based multimodal fusion deep learning framework for cancer drug response prediction	21
DMMIC derivatization-assisted liquid chromatography-mass spectrometry method for metabolite profiling of the glutathione anabolic pathway in esophageal cancer tissues and cells	21
Novel assays for quality evaluation of XueBiJing: Quality variability of a Chinese herbal injection for sepsis management	21
Dihydroartemisinin ameliorates innate inflammatory response induced by Streptococcus suis-derived muramidase-released protein via inactivation of TLR4-dependent NF-κB signaling	21
Intrinsic gallium-68 labeling of nanoclays for in vivo tracking	21
Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota	21
CeFe nanofibrous carbon nanozyme integrated with smartphone for the point-of-care testing of norfloxacin in water	21
Preparation of Fe3O4@SW-MIL-101-NH2 for selective pre-concentration of chlorogenic acid metabolites in rat plasma, urine, and feces samples	21
A Scd1-mediated metabolic alteration participates in liver responses to low-dose bavachin	20
Hypothalamic lipidomics reveals that AMPK-FA metabolism mediates the energy-balancing effect of the four typical “hot” herbs on hypothyroidism	20
Neuroinflammation attenuation effects by celastrol and PDIA3 in the amygdala, hippocampus and dorsal raphe nucleus of obese mice	20
Small-molecule probes based on natural products: Elucidation of drug-target mechanisms in stroke	20
GB7 acetate, a galbulimima alkaloid from Galbulimima belgraveana, possesses anticancer effects in colorectal cancer cells	20
Influence of traditional Chinese medicines on the in vivo metabolism of lopinavir/ritonavir based on UHPLC-MS/MS analysis	20
A gene set enrichment analysis for cancer hallmarks	20
Unlocking the potential of atractylenolide II: mitigating non-alcoholic fatty liver disease through farnesoid X receptor-endoplasmic reticulum stress interplay	20
Sensitive detection of microRNAs using polyadenine-mediated fluorescent spherical nucleic acids and a microfluidic electrokinetic signal amplification chip	20
In silico prediction of pKa values using explainable deep learning methods	20
Characterization of preclinical radio ADME properties of ARV-471 for predicting human PK using PBPK modeling	20
Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis	19
Applications and safety of gold nanoparticles as therapeutic devices in clinical trials	19
Editorial Board	19
Editorial Board	19
Absolute bioavailability, dose proportionality, and tissue distribution of rotundic acid in rats based on validated LC-QqQ-MS/MS method	18
A review of research methods for elucidating the microstructure of pharmaceutical preparations	18
Development and validation of a static multiple light scattering (SMLS) method for real-time colloidal stability assessment in nanoparticle formulations	18
Silent or low expression of blaTEM and blaSHV suggests potential for targeted proteomics in clinical detection of β-lactamase-related antimicrobial resistance	18
Screen of FDA-approved drug library identifies vitamin K as anti-ferroptotic drug for osteoarthritis therapy through Gas6	18
Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis	18
WITHDRAWN: Targeted protein degradation: A promising approach for cancer treatment	18
Advancing drug safety and mitigating health concerns: High-resolution mass spectrometry in the levothyroxine case study	18
YTE-17 inhibits colonic carcinogenesis by resetting antitumor immune response via Wnt5a/JNK mediated metabolic signaling	17
A promising strategy of brain targeted delivery for the treatment of Parkinson's disease: Cyclodextrin supramolecular inclusion complex based thermosensitive gel	17
Intestinal anti-inflammatory drug targets as potential modifiers of cardiovascular disease risk	17
Polyphyllin VII promotes hepatic stellate cell ferroptosis via the HIC1/CX3CL1/GPX4 axis	17
β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects	17
Metabolomics: A useful tool for ischemic stroke research	17
Screening of glycan biomarkers for early detection of colorectal cancer based on novel isotope labeling relative quantitative method	16
17β-Estradiol, through activating the G protein-coupled estrogen receptor, exacerbates the complication of benign prostatic hyperplasia in type 2 diabetes mellitus patients by inducing prostate prolif	16
A comprehensive review on herbal approaches for treatment of urinary tract infections: Scope and challenges	16
Editorial Board	16
Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: Integration of herbal medicine, enzyme engineering, and nanotechnology	16
TCMKD: From ancient wisdom to modern insights-A comprehensive platform for traditional Chinese medicine knowledge discovery	16
Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases	16
Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease	16
Discovery of pulmonary fibrosis inhibitor targeting TGF-β RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy	15
In Vivo Analysis Techniques for Antibody Drug: Recent Advances and Methodological Insights	15
A novel exploration of COL11A1's role in regulating myeloid-derived suppressor cell activation within the colon cancer microenvironment	15
Tumor-associated macrophages in hepatocellular carcinoma: Cellular plasticity and therapy resistance in crosstalk	15
Corrigendum to “Active components of Dengzhan Shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca2+/CaMKII pathway” [J. Pharm.	15
Discovery of E0199: A novel compound targeting both peripheral NaV and KV7 channels to alleviate neuropathic pain	15
Modifying current thin-film microextraction (TFME) solutions for analyzing prohibited substances: Evaluating new coatings using liquid chromatography	15
Albumin-bound kynurenic acid is an appropriate endogenous biomarker for assessment of the renal tubular OATs-MRP4 channel	15
Inosine: A broad-spectrum anti-inflammatory against SARS-CoV-2 infection-induced acute lung injury via suppressing TBK1 phosphorylation	15
Blocking the adverse outcome pathway of skin sensitization through a N-acetyl cysteine and lysine-loaded hydrogel	15
Exploring TGFBR3 in disease pathogenesis: Mechanisms, clinical implications, and pharmacological modulation	15
Strategy for cysteine-targeting covalent inhibitors screening using in-house database based LC-MS/MS and drug repurposing	14
Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis	14
High-strength antiswelling adhesive achieves both hemostasis and wound healing	14
Non-targeted and chiral amino acid metabolomics of colon cancer: Revealing novel chiral biomarkers and metabolic pathways	14
Zebrafish as a Vertebrate Model for High-Throughput Drug Toxicity Screening: Mechanisms, Novel Techniques, and Future Perspectives	14
Investigating ischemia and reperfusion-induced organ damage in severe cardiac arrest: A comprehensive proteomics perspective	14
Cocktail hepatocarcinoma therapy by a super-assembled nano-pill targeting XPO1 and ATR synergistically	14
Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice	14
Caenorhabditis elegans deep lipidome profiling by using integrative mass spectrometry acquisitions reveals significantly altered lipid networks	14
Elemene as a binding stabilizer of microRNA-145-5p suppresses the growth of non-small cell lung cancer	13

Mechanisms and therapeutic potential of YTHDF readers: linking epitranscriptomics to cancer	13
Capillary electrophoresis methods for impurity profiling of drugs: A review of the past decade	13
A high throughput strategy for traditional Chinese medicine active compound screening based on Raman spectroscopy	13
Screening strategies for quorum sensing inhibitors in combating bacterial infections	13
Identification of forsythoside A from Forsythia fruit for alleviating MAFLD via metabolic remodeling and IL-17 pathway regulation	13
A promising leap in early screening for chronic kidney disease: The smartphone-integrated handheld automated biochemical analyzer	13
Integrating explainable deep learning with multi-omics for screening progressive diagnostic biomarkers of hepatocellular carcinoma covering the “inflammation-cancer” transformation	13
Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions	13
Chemical Analysis, Antihyperglycemic Properties and Enzyme Inhibition of Opuntia dillenii (Ker Gawl.) Haw: A Detailed Analysis of Pulp and Peel Extracts	13
Dissection of triple-negative breast cancer microenvironment and identification of potential therapeutic drugs using single-cell RNA sequencing analysis	13
Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS	13
Combining transformer and 3DCNN models to achieve co-design of structures and sequences of antibodies in a diffusional manner	12
Integrated spatial metabolomics and transcriptomics decipher the hepatoprotection mechanisms of wedelolactone and demethylwedelolactone on non-alcoholic fatty liver disease	12
Recent advances in nanomaterial-based optical biosensors and their biomedical and biopharmaceutical applications	12
Targeted nano-drug delivery systems for tumor immunotherapy	12
Drug delivery system of curcumin to the lungs based on poly(3-alloxyloxy-1,2-propylene succinate)-sebacic acid copolymers	12
Emodin is a novel phosphatidylethanolamine anabolism inhibitor that reprograms lipid metabolism to overcome 5-fluorouracil resistance in colorectal cancer	12
Lipid metabolism analysis in esophageal cancer and associated drug discovery	12
Breaking the boundaries of affinity selection-mass spectrometry: From ligand screening to target-ligand interaction insights	12
Single-cell and spatially resolved omics: Advances and limitations	11
Editorial Board	11
New uses of halofuginone to treat cancer	11
Editorial Board	11
Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA	11
Software-aided efficient identification of the components of compound formulae and their metabolites in rats by UHPLC/IM-QTOF-MS and an in-house high-definition MS2 library: Sishen formula as a case	11
Application of microfluidic technology based on surface-enhanced Raman scattering in cancer biomarker detection: A review	11
Characterization of natural peptides in Pheretima by integrating proteogenomics and label-free peptidomics	11
18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs	11
Effects of polyol excipient stability during storage and use on the quality of biopharmaceutical formulations	11
Rational design of a novel specific fluorescent substrate for monitoring hUGT1A4 activity and its application in identification of selective inhibitors	11
Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal	11
Development of a novel multi-functional integrated bioconjugate effectively targeting K-Ras mutant pancreatic cancer	11
Predicting cardiotoxicity in drug development: A deep learning approach	11
Comment on: “Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors”	11
Fragmentation stability and retention time-shift obtained by LC-MS/MS to distinguish sialylated N-glycan linkage isomers in therapeutic glycoproteins	11
Editorial Board	11
Unraveling pyrrolizidine alkaloid-induced liver damage with an integrative spatial lipidomics framework	11
Gut dysbiosis aggravates cognitive deficits, amyloid pathology and lipid metabolism dysregulation in a transgenic mouse model of Alzheimer's disease	11
Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer	11
On-site rapid detection of multiple pesticide residues in tea leaves by lateral flow immunoassay	11