Cancer Biology & Medicine

Article	Citations
Mitochondrial transplantation sensitizes chemotherapy to inhibit tumor development by enhancing anti-tumor immunity	182
Eliminating cervical cancer: a global health imperative for women	96
The Warburg effect drives dedifferentiation through epigenetic reprogramming	63
Early-onset gastric cancer global burden profile, trends, and contributors	56
Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up	54
Optimizing the cancer research landscape for the benefit of patients and society: A strategic perspective of the German Cancer Research Center (DKFZ) and its partnerships with university medical cente	44
Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis	42
Stability and variability of molecular subtypes: comparative analysis of primary and metastatic triple-negative breast cancer	42
Role of the tumor microenvironment in shaping IDH-wildtype glioma plasticity, and potential therapeutic strategies	39
Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival	39
PD-1 inhibitors provide new opportunities in conversion therapy for stage IV gastric cancer	37
ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment	37
Cancer stem cells: a target for overcoming therapeutic resistance and relapse	33
Biological mechanism and immune response of MHC-II expression in tumor cells	33
ACSL3 regulates breast cancer progression via lipid metabolism reprogramming and the YES1/YAP axis	31
Chinese Society of Clinical Oncology Non-small Cell Lung Cancer (CSCO NSCLC) guidelines in 2024: key update on the management of early and locally advanced NSCLC	30
Cancer cell-derived migrasomes harboring ATF6 promote breast cancer brain metastasis via endoplasmic reticulum stress-mediated disruption of the blood-brain barrier	26
Immune checkpoint inhibitors: breakthroughs in cancer treatment	26
Nodal peripheral T-cell lymphomas in the new classification systems	24
Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a	24
A machine learning model to predict efficacy of neoadjuvant therapy in breast cancer based on dynamic changes in systemic immunity	23
Facing challenges with hope: universal immune cells for hematologic malignancies	22
Advances in lung cancer screening and early detection	22
Current treatment paradigm and survival outcomes among patients with newly diagnosed multiple myeloma in China: a retrospective multicenter study	22
Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies	21

Biological insights in non-small cell lung cancer	21
Human papillomavirus vaccination willingness under resource inequities: momentary intervention effects of an educational video	20
Glofitamab vs. real-world regimens in Chinese patients with third- or later-line relapsed/refractory diffuse large B-cell lymphoma: an external control study	18
Conceptualizing the complexity of ferroptosis to treat triple-negative breast cancer: theory-to-practice	17
Elucidating the synergistic roles of CD4+ T and dendritic cells in antitumor immunity	17
Progress toward cervical cancer elimination: global disparities and China’s contributions	17
Intricate roles of estrogen and estrogen receptors in digestive system cancers: a systematic review	17
First-line immunotherapy for advanced non-small cell lung cancer: current progress and future prospects	16
The efficacies and biomarker investigations of anti-programmed death-1 (anti-PD-1)-based therapies for metastatic bone and soft tissue sarcoma	16
A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids	16
Advances in antibody-drug conjugates for urothelial carcinoma treatment	15
Current and future trends in whole genome sequencing in cancer	15
Perspective on novel proteins encoded by circular RNAs in glioblastoma	14
PD-1 and LAG-3 dual blockade: emerging mechanisms and potential therapeutic prospects in cancer	14
Neutrophils as key regulators of tumor immunity that restrict immune checkpoint blockade in liver cancer	14
Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer	14
Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma	13
Research progress in tumor angiogenesis and drug resistance in breast cancer	13
BLM helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibi	12
Immunological and metabolic optimization of tumor neoantigen vaccines	12
Deep proteome profiling promotes whole proteome characterization and drug discovery for esophageal squamous cell carcinoma	12
Liquid-liquid phase separation in DNA double-strand break repair	12
Chromatin relaxation dynamics and histone PTMs in the early DNA damage response	12
Anti-tumor pharmacology of natural products targeting mitosis	12
From dichotomy to diversity: deciphering the multifaceted roles of tumor-associated macrophages in cancer progression and therapy	12
CAR T-cell therapy for relapsed/refractory CD5-positive diffuse large B-cell lymphoma yields more favorable outcomes than standard therapy	11
PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas	11
Treatment strategies for patients with HER2-positive gastric cancer	11
A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer	10
Optimal immunotherapy duration in advanced NSCLC: defining the ideal treatment window	10
Major roles of the circadian clock in cancer	10
Single-arm trials for domestic oncology drug approvals in China	10
Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer	10
Next-generation antibody–drug conjugates revolutionize the precise classification and treatment of HER2-expressing breast cancer	10
The role of intestinal flora on tumorigenesis, progression, and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer	10
Drug clinical trials on high-grade gliomas: challenges and hopes	9
Early detection of gastric cancer in China: progress and opportunities	9
Chidamide suppresses macrophage-mediated immune evasion and tumor progression in small cell lung cancer by targeting the STAT4/CCL2 signaling pathway	9
Cancer risk in relatives of BRCA1/2 pathogenic variant carriers in a large series of unselected patients with breast cancer	9
Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer	9
The evidence and concerns about screening ultrasound for breast cancer	9
Current status of management of immune-related adverse events and practical needs for oncologist education	9
Metabolic regulation of immune responses to cancer	9
Potential treatment approaches for malignant peritoneal mesothelioma: in vivo and in vitro experimental study of natural killer cell immunotherapy	8
The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer	8
Erratum to DYRK1A suppression restrains Mcl-1 expression and sensitizes NSCLC cells to Bcl-2 inhibitors	8
Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) guidelines in 2022: stratification and classification	8
MicroRNA-384 radiosensitizes human non-small cell lung cancer by impairing DNA damage response and repair signaling, which is inhibited by NF-κB	8
N6-methyladenosine (m6A) RNA modification in tumor immunity	8
Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer	8

Recent progress in targeting the sialylated glycan-SIGLEC axis in cancer immunotherapy	8
Modeling cervical cancer elimination: a pathway to inform policy decisions	8
Treatment strategies for advanced neuroendocrine neoplasms: current status and future prospects	8
Understanding the mechanisms underlying obesity in remodeling the breast tumor immune microenvironment: from the perspective of inflammation	8
Erianin inhibits the proliferation of lung cancer cells by suppressing mTOR activation and disrupting pyrimidine metabolism	7
Azoximer bromide and hydroxyapatite: promising immune adjuvants in cancer	7
Senescent macrophages in cancer: roles in tumor progression and treatment opportunities	7
Decoding the complexity of metastasis	7
Identifying occult high-risk features and stratified management strategies following curative resection for ampullary adenocarcinoma	7
Development of glioblastoma organoids and their applications in personalized therapy	7
Epigenetic regulators as the foundation for molecular classification of colorectal cancer	7
Targeting PP2A for cancer therapeutic modulation	7
Mutations in Ras homolog family member A in patients with peripheral T-cell lymphoma and implications for personalized medicine	7
Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma	6
Bilirubin inhibits the anticancer activity of sorafenib by blocking MCL-1 degradation in hepatocellular carcinoma cells	6
Neoantigen cancer vaccines: a new star on the horizon	6
Therapeutic perspectives for adult soft tissue sarcoma—updates from the 2022 ASCO annual meeting	6
Extracellular vesicle-mediated heterogeneous communication between cancer and the lymphatic system facilitates lymphatic metastasis	6
MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis	6
Global, regional, and national burden of early-onset gastric cancer	6
Genomic medicine in clinical practice: national genomic medicine program in Japan	6
The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan	6
Accelerating the elimination of global cervical cancer through intelligent training for colposcopy	6
The inducible secreting TLR5 agonist, CBLB502, enhances the anti-tumor activity of CAR133-NK92 cells in colorectal cancer	6
A therapeutic multi-epitope protein vaccine targeting HPV16 E6 E7 elicits potent tumor regression and cytotoxic immune responses	6
Erratum to Treatment strategies for patients with HER2-positive gastric cancer	6
Integrated pretreatment stratification system for pancreatic cancer: combining anatomical resectability and tumor biological parameters	6
Bispecific antibodies targeting immunomodulatory checkpoints for cancer therapy	5
Hub genes associated with immune cell infiltration in breast cancer, identified through bioinformatic analyses of multiple datasets	5
Chemotherapy-free radiotherapy combined with immune checkpoint inhibitors: a new regimen for locally advanced non-small cell lung cancer?	5
Expanding horizons in overcoming therapeutic resistance in castration-resistant prostate cancer: targeting the androgen receptor-regulated tumor immune microenvironment	5
Plasma L-aspartic acid predicts the risk of gastric cancer and modifies the primary prevention effect: a multistage metabolomic profiling and Mendelian randomization study	5
Detection and surveillance of circulating tumor cells in osteosarcoma for predicting therapy response and prognosis	5
Cervical cancer burden and trends in China, 2000–2020: Asia-Pacific international comparisons and insights for elimination goals	5
Safety and efficacy of intraoperative radiation therapy using a low-energy X-ray source for resectable pancreatic cancer: an interim evaluation of an ongoing prospective phase II study	5
Angiogenesis in hepatocellular carcinoma: mechanisms and anti-angiogenic therapies	5
Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP	5
National prevention programs and their effects on gastric cancer Incidence and mortality in East Asian countries	5
Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population	5
Multifaceted efforts of governments, medical institutions, and financial organizations contribute to reducing the health inequality caused by economic differences	5
Evolving molecular subtyping of breast cancer advances precision treatment	5
Recent advances in the systemic treatment of gastrointestinal stromal tumors	5
Organoid models in oncology: advancing precision cancer therapy and vaccine development	5
Immunotherapy for multiple myeloma: new chances and hope	5
Potential new applications of immunotherapy for neuroendocrine neoplasms: immune landscape, current status and future perspectives	5
Single-cell RNA sequencing reveals spatial heterogeneity and immune evasion of circulating tumor cells	5
Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies	5
Highlighted multi-modifications of enzymes: a novel succinylation mediated by histone acetyltransferase 1 in tumors	5
Peptide drugs: a new direction in cancer immunotherapy	5
IL-33/ST2 signalling promotes tumor growth by regulating polarization of alternatively activated macrophages	4
Integrating artificial intelligence into radiological cancer imaging: from diagnosis and treatment response to prognosis	4
Bile acids, gut microbiota, and therapeutic insights in hepatocellular carcinoma	4
Biomarkers for immune checkpoint inhibitors in colorectal cancer: recent advances and future perspectives	4
XPO1 as a key regulator in small cell lung cancer: mechanisms, biomarkers, and therapeutic implications	4
Exosomal miR-155 from gastric cancer induces cancer-associated cachexia by suppressing adipogenesis and promoting brown adipose differentiation via C/EPBβ	4
SETD2 in cancer: functions, molecular mechanisms, and therapeutic regimens	4
CSCO guidelines for metastatic colorectal cancer: personalized medicine in clinical practice	4
Comparing effectiveness and safety of paclitaxel plus raltitrexed vs. paclitaxel alone in second-line palliative chemotherapy for metastatic gastric adenocarcinoma: A randomized phase II clinical tria	4
Weight gain after 35 years of age is associated with increased breast cancer risk: findings from a large prospective cohort study	4
Mechanism and effects of extramedullary hematopoiesis on anti-tumor immunity	4
Nanomedicine-based combination therapies for overcoming temozolomide resistance in glioblastomas	4
Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma	4
Feasibility of sentinel lymph node biopsy omission after integration of 18F-FDG dedicated lymph node PET in early breast cancer: a prospective phase II trial	4
Rosiglitazone disrupts pancreatic ductal adenocarcinoma progression by activating the tumor suppressor ESE3/EHF	4
Prospective study of the effect of ERAS on postoperative recovery and complications in patients with gastric cancer	4
Acetylated-PPARγ expression is regulated by different P53 genotypes associated with the adipogenic differentiation of polyploid giant cancer cells with daughter cells	4
Global disparities in childhood neuroblastoma: trends, burden, and inequities from 1990 to 2021	4
The interplay between RNA m<sup>6</sup>A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review	4
Lactate and lactylation in breast cancer: current understanding and therapeutic opportunities	4
Effects of population aging on the mortality burden of related cancers in urban and rural areas of China, 2004–2017: a population-based study	4
Inflammatory signaling in targeted therapy resistance: focus on EGFR-targeted treatment	4
Increased and persistent absolute CD4&#x002B; T cell count in an HIV-associated Burkitt lymphoma patient with central nervous system involvement after axicabtagene ciloleucel therapy	3
Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) Guidelines in 2024: International Contributions from China	3
Recent research hotspots in sequencing and the pancreatic neuroendocrine tumor microenvironment	3
Microbiome changes in esophageal cancer: implications for pathogenesis and prognosis	3
Multi-omics in colorectal cancer liver metastasis: applications and research advances	3
Antibody-drug conjugates in breast cancer: advances and prospects	3
Natural killer cells in tumor immunotherapy	3
Tumor-related fungi and crosstalk with gut fungi in the tumor microenvironment	3
Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells	3

Insight into the evolution of breast cancer driven by genetic alterations	3
Esophageal cancer global burden profiles, trends, and contributors	3
Retrospective analysis of disease characteristics and treatment patterns among patients with esophageal cancer across 14 surgically represented centers	3
Genomic medicine and cancer clinical trial in Thailand	3
Influence of sex on outcomes of liver transplantation for hepatocellular carcinoma: a multicenter cohort study in China	3
Methods for monitoring cancer cell pyroptosis	3
Innate IgM antibodies to mannose in patients with gastric cancer	3
Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencing	3
Involvement of lncRNAs in the tumor microenvironment: a new property of tumor immunity	3
Evolution-driven crosstalk between glioblastoma and the tumor microenvironment	3
Epigenetic reprogramming in small cell lung cancer	2
DB-1310, a HER3-targeting antibody-drug conjugate, has synergistic anti-tumor activity with trastuzumab in HER2- and HER3-expressing breast cancer	2
Emerging roles of plasmacytoid dendritic cell crosstalk in tumor immunity	2
Evaluation of an intelligent digital platform for population management in cervical cancer screening	2
Attitude towards genetic testing for breast cancer susceptibility genes and choice of prevention strategies in Chinese women with or without breast cancer	2
Update on diffuse large B-cell lymphoma: highlights from the 2022 ASCO Annual Meeting	2
Progress in clinical diagnosis and treatment of colorectal cancer with rare genetic variants	2
Mission of the National Cancer Center Hospital in Japan to promote clinical trials for precision medicine	2
Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration	2
Clinical management and survival outcomes of patients with different molecular subtypes of diffuse gliomas in China (2011–2017): a multicenter retrospective study from CGGA	2
Current status of traditional Chinese medicine in modulating mitochondrial metabolic abnormalities in tumors	2
Strengthening human papillomavirus vaccination programs through multi-country peer learning: lessons from the CHIC initiative	2
Comprehensive strategies for management of postoperative hyper-progression recurrence (HPR) of hepatocellular carcinoma: a 12-year large sample multi-center study	2
Mechanisms underlying prostate cancer sensitivity to reactive oxygen species: overcoming radiotherapy resistance and recent clinical advances	2
The outpost against cancer: universal cancer only markers	2
A retrospective analysis of mature T- and NK-cell lymphomas	2
IL-17A blockade alleviates immune checkpoint inhibitor-associated psoriasiform rash: preclinical and clinical responses	2
Breast surgeons at the forefront: preserving lymph nodes for enhanced immunotherapy efficacy	2
The mechanisms and clinical significance of CD8+ T cell exhaustion in anti-tumor immunity	2
The arginine metabolism battlefield: how metabolite exchange in the tumor microenvironment shapes an immunosuppressive ecosystem	2
MDM1 overexpression promotes p53 expression and cell apoptosis to enhance therapeutic sensitivity to chemoradiotherapy in patients with colorectal cancer	2
Circulating cell-free mtDNA as a new biomarker for cancer detection and management	2
Hot issues in triple-negative breast cancer	2
The interplay between H3K36 methylation and DNA methylation in cancer	2
Cervical cancer prevention in China: where are we now, and what’s next?	2
Revolutionizing tumor immunotherapy: unleashing the power of progenitor exhausted T cells	2
Application and future prospects of bispecific antibodies in the treatment of non-small cell lung cancer	2
Combined chemo-endocrine therapy as a potential new option for HR+/HER2− advanced breast cancer: a prospective study of fulvestrant plus oral vinorelbine	2
Repurposing drugs for solid tumor treatment: focus on immune checkpoint inhibitors	2
Improved treatment of colorectal liver metastases by early response evaluation and regimen adjustment: a prospective study of clinical functional MR-based modeling	2
Research progress in hepatitis B virus covalently closed circular DNA	2