Cancer Biology & Medicine

Article	Citations
Multiplex imaging reveals the architecture of the tumor immune microenvironment	133
Emerging roles of plasmacytoid dendritic cell crosstalk in tumor immunity	66
Therapeutic revolution for inoperable stage III non-small cell lung cancer in the immune era	42
Peptide drugs: a new direction in cancer immunotherapy	42
The choice of a neoadjuvant chemotherapy cycle for breast cancer has significance in clinical practice: results from a population-based, real world study	39
Hot issues in triple-negative breast cancer	37
Drug clinical trials on high-grade gliomas: challenges and hopes	34
Highlighted multi-modifications of enzymes: a novel succinylation mediated by histone acetyltransferase 1 in tumors	32
Metabolic regulation of innate immunity in cancer immunotherapy	32
Recent advances in the systemic treatment of gastrointestinal stromal tumors	24
Recent progress in targeting the sialylated glycan-SIGLEC axis in cancer immunotherapy	23
The interplay between H3K36 methylation and DNA methylation in cancer	20
Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies	19
Revolutionizing tumor immunotherapy: unleashing the power of progenitor exhausted T cells	19
Super-enhancer receives signals from the extracellular matrix to induce PD-L1-mediated immune evasion via integrin/BRAF/TAK1/ERK/ETV4 signaling	19
A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer	19
Potential new applications of immunotherapy for neuroendocrine neoplasms: immune landscape, current status and future perspectives	18
DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation	18
Evolving molecular subtyping of breast cancer advances precision treatment	18
JaponiconeA induces apoptosis of bortezomib-sensitive and -resistant myeloma cells in vitro and in vivo by targeting IKKβ	17
The outpost against cancer: universal cancer only markers	17
Cancer risk in relatives of BRCA1/2 pathogenic variant carriers in a large series of unselected patients with breast cancer	16
Progress on immuno-microenvironment and immune-related therapies in patients with pseudomyxoma peritonei	16
Single-arm trials for domestic oncology drug approvals in China	16
Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance	15

Next-generation antibody–drug conjugates revolutionize the precise classification and treatment of HER2-expressing breast cancer	15
Advances in MET tyrosine kinase inhibitors in gastric cancer	15
IL13Rα1 prevents a castration resistant phenotype of prostate cancer by targeting hexokinase 2 for ubiquitin-mediated degradation	13
Using triple radio-immunotherapy to overcome cancer immunotherapy resistance	12
Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population	12
Circulating cell-free mtDNA as a new biomarker for cancer detection and management	12
Identification of hub genes and their novel diagnostic and prognostic significance in pancreatic adenocarcinoma	11
Optimal immunotherapy duration in advanced NSCLC: defining the ideal treatment window	11
Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer	11
Comparative profiling of immune genes improves the prognoses of lower grade gliomas	10
Epigenetic reprogramming in small cell lung cancer	9
Update on diffuse large B-cell lymphoma: highlights from the 2022 ASCO Annual Meeting	9
Expanding horizons in overcoming therapeutic resistance in castration-resistant prostate cancer: targeting the androgen receptor-regulated tumor immune microenvironment	8
Research progress in hepatitis B virus covalently closed circular DNA	8
Roles of eIF5A in the immunosurveillance of cellular senescence	8
Complex role of neutrophils in the tumor microenvironment: an avenue for novel immunotherapies	8
DB-1310, a HER3-targeting antibody-drug conjugate, has synergistic anti-tumor activity with trastuzumab in HER2- and HER3-expressing breast cancer	8
Metabolic regulation of immune responses to cancer	8
The role of DLL1 in long-term vascular normalization and cancer immunotherapy	8
Impact of cancer diagnosis on life expectancy by area-level socioeconomic groups in New South Wales, Australia: a population-based study	8
Microsurgery vs. radiosurgery for the treatment of multiple metastases in the brain: a retrospective cohort study	8
Cohort profile: design and methods of the Chinese colorectal, breast, lung, liver, and stomach cancer screening trial (C-BLAST)	7
Intercellular transmission of cGAS-STING signaling in cancer	7
Clinical management and survival outcomes of patients with different molecular subtypes of diffuse gliomas in China (2011–2017): a multicenter retrospective study from CGGA	7
EZH2 identifies the precursors of human natural killer cells with trained immunity	7
Bacterial outer membrane vesicle-based cancer nanovaccines	7
Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data	7
Safety and efficacy of intraoperative radiation therapy using a low-energy X-ray source for resectable pancreatic cancer: an interim evaluation of an ongoing prospective phase II study	7
Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) guidelines in 2022: stratification and classification	7
The Warburg effect drives dedifferentiation through epigenetic reprogramming	6
Early detection of gastric cancer in China: progress and opportunities	6
Targeting the EGF receptor family in non-small cell lung cancer—increased complexity and future perspectives	6
Frequent low dose alcohol intake increases gastric cancer risk: the Health Examinees-Gem (HEXA-G) study	6
Development of small molecule drugs targeting immune checkpoints	6
Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up	6
2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma	6
Progress in oncolytic viruses modified with nanomaterials for intravenous application	5
The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer	5
Roles of cancer-associated fibroblast functional heterogeneity in shaping the lymphatic metastatic landscape: new insights and therapeutic strategies	5
Chinese Society of Clinical Oncology Non-small Cell Lung Cancer (CSCO NSCLC) guidelines in 2024: key update on the management of early and locally advanced NSCLC	5
Circular RNAs: implications of signaling pathways and bioinformatics in human cancer	5
Platinum is essential in neoadjuvant treatment of triple-negative breast cancer: a network meta-analysis	5
Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy	5
Role of the tumor microenvironment in shaping IDH-wildtype glioma plasticity, and potential therapeutic strategies	5
Cancer immunology and immunotherapy	5
The active surveillance management approach for patients with low risk papillary thyroid microcarcinomas: is China ready?	5
Understanding the mechanisms underlying obesity in remodeling the breast tumor immune microenvironment: from the perspective of inflammation	5
Single-cell RNA sequencing reveals spatial heterogeneity and immune evasion of circulating tumor cells	5
PD-1 inhibitors provide new opportunities in conversion therapy for stage IV gastric cancer	5
Artificial intelligence strengthenes cervical cancer screening – present and future	5

Improved treatment of colorectal liver metastases by early response evaluation and regimen adjustment: a prospective study of clinical functional MR-based modeling	5
Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II tria	5
Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed glioblastoma: a multicenter, single-arm, phase II trial	5
Reflections on the withdrawal of medical articles and the development of writing and publishing standards	4
Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival	4
Prognostic significance of a combined and controlled nutritional status score and EBV-DNA in patients with advanced nasopharyngeal carcinoma: a long-term follow-up study	4
Diagnosis of malnutrition in cancer patients	4
Bile acids, gut microbiota, and therapeutic insights in hepatocellular carcinoma	4
Multifaceted efforts of governments, medical institutions, and financial organizations contribute to reducing the health inequality caused by economic differences	4
Precision medicine in the treatment of colorectal cancer with liver metastases	4
Enhancement of anti-PD-L1 antibody plus anlotinib efficacy due to downregulation of PD-L1 in the micro-conduit endothelium within the tumor: a randomized double-blind trial	4
Multiple myeloma survival in New South Wales, Australia, by treatment era to 2020	4
SY-1530, a highly selective BTK inhibitor, effectively treats B-cell malignancies by blocking B-cell activation	4
Stability and variability of molecular subtypes: comparative analysis of primary and metastatic triple-negative breast cancer	4
The mutation landscape of multiple cancer predisposition genes in Chinese familial/hereditary breast cancer families	4
ACSL3 regulates breast cancer progression via lipid metabolism reprogramming and the YES1/YAP axis	4
Deep-learning methods for unveiling large-scale single-cell transcriptomes	4
Inconsistent radiotherapy effects between primary tumors and axillary lymph nodes	4
Optimizing the cancer research landscape for the benefit of patients and society: A strategic perspective of the German Cancer Research Center (DKFZ) and its partnerships with university medical cente	4
N6-methyladenosine (m6A) RNA modification in tumor immunity	3
Immune checkpoint inhibitors: breakthroughs in cancer treatment	3
Repurposing drugs for solid tumor treatment: focus on immune checkpoint inhibitors	3
ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment	3
Cancer metabolism and dietary interventions	3
Breast cancer screening and early diagnosis in Chinese women	3
Progress in clinical diagnosis and treatment of colorectal cancer with rare genetic variants	3
Integrating artificial intelligence into radiological cancer imaging: from diagnosis and treatment response to prognosis	3
Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies	3
Immunology and immunotherapy in breast cancer	3
Potential treatment approaches for malignant peritoneal mesothelioma: in vivo and in vitro experimental study of natural killer cell immunotherapy	3
MicroRNA-384 radiosensitizes human non-small cell lung cancer by impairing DNA damage response and repair signaling, which is inhibited by NF-κB	3
Expert opinion on translational research for advanced glioblastoma treatment	3
A novel expressed prostatic secretion (EPS)-urine metabolomic signature for the diagnosis of clinically significant prostate cancer	3
Simultaneous integrated dose reduction intensity-modulated radiotherapy effectively reduces cardiac toxicity in limited-stage small cell lung cancer	2
Safety and efficacy of anti-EGFR monoclonal antibody (SCT200) as second-line therapy in advanced esophageal squamous cell carcinoma	2
Decreased LDHB expression in breast tumor cells causes NK cell activation and promotes tumor progression	2
Smart drug delivery systems to overcome drug resistance in cancer immunotherapy	2
A CRISPR-Cas9 screen shows the combination efficacy of lenvatinib plus epidermal growth factor receptor inhibitors for treatment of liver cancer	2
Neutrophils in the era of single-cell RNA sequencing: functions and targeted therapies in cancer	2
PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells	2
Efficacy and safety of gemcitabine plus S-1 vs. gemcitabine plus nab-paclitaxel in treatment-naïve advanced pancreatic ductal adenocarcinoma	2
Attitude towards genetic testing for breast cancer susceptibility genes and choice of prevention strategies in Chinese women with or without breast cancer	2
Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer	2
The emerging role of long noncoding RNA RMRP in cancer development and targeted therapy	2
Detection and surveillance of circulating tumor cells in osteosarcoma for predicting therapy response and prognosis	2
Erratum to DYRK1A suppression restrains Mcl-1 expression and sensitizes NSCLC cells to Bcl-2 inhibitors	2
The Hippo/YAP signaling pathway: the driver of cancer metastasis	2
Weight gain after 35 years of age is associated with increased breast cancer risk: findings from a large prospective cohort study	2
From complexity to clarity: development of CHM-FIEFP for predicting effective components in Chinese herbal formulas by using big data	2
Bronchoalveolar lavage fluid assessment facilitates precision medicine for lung cancer	2
Azoximer bromide and hydroxyapatite: promising immune adjuvants in cancer	2
Regulatory role of exosomes in colorectal cancer progression and potential as biomarkers	2
Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a	2
A retrospective analysis of mature T- and NK-cell lymphomas	2
Mechanism and effects of extramedullary hematopoiesis on anti-tumor immunity	2
Comparing effectiveness and safety of paclitaxel plus raltitrexed vs. paclitaxel alone in second-line palliative chemotherapy for metastatic gastric adenocarcinoma: A randomized phase II clinical tria	2
Cancer stem cells: a target for overcoming therapeutic resistance and relapse	2
Decoding the complexity of metastasis	2
Combined chemo-endocrine therapy as a potential new option for HR+/HER2− advanced breast cancer: a prospective study of fulvestrant plus oral vinorelbine	2
The current role of dendritic cells in the progression and treatment of colorectal cancer	2
Advances in ATM, ATR, WEE1, and CHK1/2 inhibitors in the treatment of PARP inhibitor-resistant ovarian cancer	2
Acetylated-PPARγ expression is regulated by different P53 genotypes associated with the adipogenic differentiation of polyploid giant cancer cells with daughter cells	2
Nodal peripheral T-cell lymphomas in the new classification systems	2
A machine learning model to predict efficacy of neoadjuvant therapy in breast cancer based on dynamic changes in systemic immunity	2
Cancer-educated neutrophils promote lung cancer progression via PARP-1-ALOX5-mediated MMP-9 expression	2
Mission of the National Cancer Center Hospital in Japan to promote clinical trials for precision medicine	2
Reducing the global cancer burden with gastrointestinal screening: China’s 30 years practice	2
Erratum to A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis	2
Epigenetic regulators as the foundation for molecular classification of colorectal cancer	2
CSCO guidelines for metastatic colorectal cancer: personalized medicine in clinical practice	1
Improving the value of molecular testing: current status and opportunities in colorectal cancer precision medicine	1
DNA methylation profiles in cancer: functions, therapy, and beyond	1
Analysis of characteristics and predictive factors of immune checkpoint inhibitor-related adverse events	1
Current therapeutic landscape and resistance mechanisms to larotrectinib	1
Conceptualizing the complexity of ferroptosis to treat triple-negative breast cancer: theory-to-practice	1
Hodgkin’s lymphoma: 2023 update on treatment	1
The interplay between RNA m<sup>6</sup>A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review	1
The inducible secreting TLR5 agonist, CBLB502, enhances the anti-tumor activity of CAR133-NK92 cells in colorectal cancer	1
The advanced development of molecular targeted therapy for hepatocellular carcinoma	1
Advances in gut microbiota-related treatment strategies for managing colorectal cancer in humans	1

Treatment strategies for advanced neuroendocrine neoplasms: current status and future prospects	1
MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis	1
Biological insights in non-small cell lung cancer	1
TNFSF15 facilitates the differentiation of CD11b+ myeloid cells into vascular pericytes in tumors	1
Repurposing glucocorticoids as adjuvant reagents for immune checkpoint inhibitors in solid cancers	1
Erratum to Treatment strategies for patients with HER2-positive gastric cancer	1
Impact of metabolic dysfunction-associated steatotic liver disease on the efficacy of immunotherapy in patients with chronic hepatitis B-related hepatocellular carcinoma	1
Effects of population aging on the mortality burden of related cancers in urban and rural areas of China, 2004–2017: a population-based study	1
Biomarkers for immune checkpoint inhibitors in colorectal cancer: recent advances and future perspectives	1
Rosiglitazone disrupts pancreatic ductal adenocarcinoma progression by activating the tumor suppressor ESE3/EHF	1
Facing challenges with hope: universal immune cells for hematologic malignancies	1
Advancing precision medicine: the transformative role of artificial intelligence in immunogenomics, radiomics, and pathomics for biomarker discovery and immunotherapy optimization	1
Targeting PP2A for cancer therapeutic modulation	1
Erianin inhibits the proliferation of lung cancer cells by suppressing mTOR activation and disrupting pyrimidine metabolism	1
Deciphering gastric inflammation-induced tumorigenesis through multi-omics data and AI methods	1
Nanomedicine-based combination therapies for overcoming temozolomide resistance in glioblastomas	1
Calcification-associated molecular traits and therapeutic strategies in hormone receptor-positive HER2-negative breast cancer	1
Real-world effectiveness and safety of goserelin 10.8-mg depot in Chinese patients with localized or locally advanced prostate cancer	1
New era: prospects for managing cancer of unknown primary	1
Development of glioblastoma organoids and their applications in personalized therapy	1
Prospective study of the effect of ERAS on postoperative recovery and complications in patients with gastric cancer	1
Preoperative ultrasound combined with routine blood tests in predicting the malignant risk of pancreatic cystic neoplasms	1
Heterogeneity of neutrophils in cancer: one size does not fit all	1
Road of no return — loss of TP53 paves a defined evolution path from gastric preneoplasia-to-cancer	1
Advances in lung cancer screening and early detection	1
Treatment patterns and a prognostic scoring system for elderly acute myeloid leukemia patients: a retrospective multicenter cohort study in China	1
Continuous R-DA-EDOCH alternated with high-dose Ara-C induces deep remission and overcomes high-risk factors in young patients with newly diagnosed mantle cell lymphoma	1
Advances and challenges in gastric cancer testing: the role of biomarkers	1
Local consolidative therapy in oligometastatic non-small-cell lung cancer after effective systemic treatment: who will benefit?	1
Current cancer burden in China: epidemiology, etiology, and prevention	1
Current treatment paradigm and survival outcomes among patients with newly diagnosed multiple myeloma in China: a retrospective multicenter study	1