OOIR: Observatory of International Research

Papers

(The TQCC of Current Medical Science is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Effect of An Atmospheric Plasma Jet on the Differentiation of Melanoblast Progenitor	160
FMR1NB Involved in Glioma Tumorigenesis Is a Promising Target for Prognosis and Therapy	137
Downregulation of Cav3.1 T-type Calcium Channel Expression in Age-related Hearing Loss Model	60
Surgical Treatment of Craniopharyngiomas in Adults: Comparison between Primary Surgery and Surgery for Recurrence	35
Enhancing Orthopedic Knowledge Assessments: The Performance of Specialized Generative Language Model Optimization	35
Development of a Compact Photoacoustic Tomography Imaging System with Dual Single-Element Transducers for Image Enhancement	34
Construction of Influenza Early Warning Model Based on Combinatorial Judgment Classifier: A Case Study of Seasonal Influenza in Hong Kong	31
Age-dependent Changes in Skeletal Muscle Mass and Visceral Fat Area in a Chinese Population	30
Ticagrelor Protects against Sepsis-Induced Acute Kidney Injury through an Adenosine Receptor-Dependent Pathway	27
Effect of Dual Trigger In Vitro Fertilization and Intracytoplasmic Sperm Injection During the Gonadotropin-releasing Hormone-Antagonist Cycle on Final Oocyte Maturation and Cumulative Live Birth Rate	24
Circulating T Regulatory Cells Are Persistently Reduced in Non-Severe Acquired Aplastic Anemia	22
Effect of Continuous Erector Spinae Plane Block on Postoperative Recovery in Patients Undergoing Minimally Invasive Cardiac Surgery: A Prospective, Randomized Controlled Clinical Trial	22
Value of Contrast-enhanced Ultrasound in Evaluating Synovitis and Predicting Recurrent Joint Bleeding of Hemophilia	19
Interleukin-6: Molecular Mechanisms and Therapeutic Perspectives in Atrial Fibrillation	19
Incidence, Survival Outcome, and Prognostic Nomogram of Patients with Angioimmunoblastic T-cell Lymphoma: a Population-based Analysis	19
TSR: A User-Friendly R Shiny Application for Assessment of Optimal Blood Product Selection in ABO-Incompatible Hematopoietic Stem Cell Transplantation	18
A Prediction Model for Detecting Dysthyroid Optic Neuropathy Based on Clinical Factors and Imaging Markers of the Optic Nerve and Cerebrospinal Fluid in the Optic Nerve Sheath	16
Outcomes of Three Different Minimal Invasive Approaches for Secundum Atrial Septal Defect Closure: A Single Institute Experience	16
Correlation between Surface Area Ratio of Medial to Lateral Tibial Plateau and Knee Alignment in Adults	16
BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway	15
Standard-definition White-light, High-definition White-light versus Narrow-band Imaging Endoscopy for Detecting Colorectal Adenomas: A Multicenter Randomized Controlled Trial	15
Statins Combined with AAV8-TBG-LOX-1 Reduce the Vascular Lipid-driven Inflammatory Response and Inhibit Atherosclerosis	15
Curcumin Synergizes with Cisplatin to Inhibit Colon Cancer through Targeting the MicroRNA-137-Glutaminase Axis	15
Obstructive Sleep Apnea Syndrome Phenotyping by Cluster Analysis: Typical Sleepy, Obese Middle-aged Men with Desaturating Events are A Minority of Patients in A Multi-ethnic Cohort of 33% Women	14
Scoring the Clinical Application of a Novel Scale in a Hybrid Operating Room for Neurosurgery	14

Effect of Jianpi Shengxue Tablet on Iron Metabolism and Nutritional Status in Patients with Renal Anemia: A Prospective, Randomized, Open, Parallel Controlled and Multicenter Clinical Study	14
Acid Water-ground Nano-realgar Is Superior to Crude Realgar in Promoting Apoptosis of MCF-7 Breast Cancer Cells	14
Hope During the COVID-19 Epidemic Decreased Anxiety and Depression Symptoms Mediated by Perceived Stress: Coping Style Differences Among Patients with COVID-19	13
Imbalance of Circulating Follicular Regulatory and Follicular Helper T Cell Subpopulations Is Associated with Disease Progression and Serum CYFRA 21-1 Levels in Patients with Non-small Cell Lung Cance	13
MiR-183-5p-PNPT1 Axis Enhances Cisplatin-induced Apoptosis in Bladder Cancer Cells	13
Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer’s Disease	13
Physiological Reconstruction for Moderate–Severe Pelvic Organ Prolapse: A Multicenter Retrospective Self-Controlled Study	13
Jianpi Huoxue Decoction Ameliorates Alcohol-associated Liver Disease by Improving Intestinal Barrier Function in Rats	12
Correlation between the Human Development Index and the Incidence and Mortality of Non-Hodgkin Lymphoma	12
Targeting Glycolytic Enzymes with 3-Bromopyruvic Acid to Enhance the Efficacy of Interventional Embolization in Hepatocellular Carcinoma	12
Acupuncture Treats Sepsis through Immune Modulation and Organ Protection	12
Erratum to: PHOSPHO1 Serves as a Key Metabolism-Related Biomarker in the Tumorigenesis of Diffuse Large B-cell Lymphoma	12
The Role of Casr Inhibition-Mediated M2 Microglial Transformation in Ischemic Preconditioning Against Stroke	12
Transforming Adolescent Smiles: Correcting Skeletal Mandibular Retrusion and Bimaxillary Protrusion with Clear Aligners	12
Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia	11
Development and Validation of a Nomogram for Predicting the 1-, 3-, and 5-year Survival in Patients with Acinar-predominant Lung Adenocarcinoma	10
NOX4 Suppresses Ferroptosis Through Regulation of the Pentose Phosphate Pathway in Colorectal Cancer	10
Advances and Challenges in Adeno-Associated Virus Gene Therapy Applications of Localized Delivery Strategies	10
Bioinformatic and Experimental Analyses Reveal That KIF4A Is a Biomarker of Therapeutic Sensitivity and Predicts Prognosis in Cervical Cancer Patients	10
Mixed Infections in the Female Lower Genital Tract: Unlocking the Current Landscape and Future Directions	10
Effects of Atmospheric Pressure Plasma in the Treatment of Experimental Periodontitis in Beagle Dogs	9
Application and Prospects of Deep Learning Technology in Fracture Diagnosis	9
LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization	9
Inhibition of Bcl-6 Expression Ameliorates Asthmatic Characteristics in Mice	9
Insights into Virus-Host Interactions: Lessons from Caenorhabditis elegans-Orsay Virus Model	9
Celastrol Induces Apoptosis and Autophagy via the AKT/mTOR Signaling Pathway in the Pituitary ACTH-secreting Adenoma Cells	9
Comment on: Clinical Characteristics, Diagnosis, and Treatments for COVID-19	8
Prognostic Value of ALP and LDH in Periampullary Carcinoma Patients Undergoing Surgery	8
A Nomogram Model for Prediction of Mortality Risk of Patients with Dangerous Upper Gastrointestinal Bleeding: A Two-center Retrospective Study	8
Roles of MT-ND1 in Cancer	8
Effects of Medication Use on Small Airway Function and Airway Inflammation in Patients with Clinically Controlled Asthma	8
Achieving Total Enteroscopy by Consecutive Bidirectional Double-balloon Enteroscopy Procedures	8
Expert Consensus on the Diagnosis and Treatment of Anticancer Drug-Induced Interstitial Lung Disease	8
ARID1A Inactivation Increases Expression of circ0008399 and Promotes Cisplatin Resistance in Bladder Cancer	8
MicroRNA-146a Promotes Embryonic Stem Cell Differentiation towards Vascular Smooth Muscle Cells through Regulation of Kruppel-like Factor 4	8
P25/CDK5-mediated Tau Hyperphosphorylation in Both Ipsilateral and Contralateral Cerebra Contributes to Cognitive Deficits in Post-stroke Mice	8
Green Tea Polyphenols Prevent Early Vascular Aging Induced by High-Fat Diet via Promoting Autophagy in Young Adult Rats	8
Retraction Note: Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation	8
Causal Links Between Gut Microbiota and Vitamin Deficiencies: Evidence from Mendelian Randomization Analysis	7
Diagnostic Value of Targeted Next-generation Sequencing in Pulmonary Mycobacterial Infections	7
Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats	7
RETRACTED ARTICLE: Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation	7
Clinical Characteristics of H1N1 Influenza A-Associated Mild Encephalopathy with Reversible Splenial Lesion: 4 Pediatric Cases	7
DLAT as a Cuproptosis Promoter and a Molecular Target of Elesclomol in Hepatocellular Carcinoma	7
LRP6 Bidirectionally Regulates Insulin Sensitivity through Insulin Receptor and S6K Signaling in Rats with CG-IUGR	7
Periplaneta Americana Extract Ameliorates LPS-induced Acute Lung Injury Via Reducing Inflammation and Oxidative Stress	7
Intrinsic Wave Velocity Propagation: A Novel Parameter for Assessing the Effect of Anthracycline Chemotherapy Agents on Cardiac Diastolic Function in Breast Cancer Patients	7
Efficacy of Sitagliptin on Nonalcoholic Fatty Liver Disease in High-fat-diet-fed Diabetic Mice	7
Liver Transplantation Outcomes of HBV-, HCV-, and Alcohol-induced Hepatocellular Carcinoma in the United States: Analysis of National Inpatient Samples	7
Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage	7

Gene Therapy Activates Retinal Pigment Epithelium Cell Proliferation for Age-related Macular Degeneration in a Mouse Model	6
Silencing MFN2 Drives WNT/β-catenin Nucleation to Reduce Sorafenib Sensitivity in Hepatocellular Carcinoma Cells	6
Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms	6
Olanzapine Induces Inflammation and Immune Response via Activating ER Stress in the Rat Prefrontal Cortex	6
The Value of Subjective Visual Vertical in Diagnosis of Vestibular Migraine	6
Correlations of Serological Markers with Development of Systemic Involvement in Adult Immunoglobulin A Vasculitis: A Retrospective Study of 259 Patients in Central China	6
The History of Controlling and Treating Infectious Diseases in Ancient China	6
Yinchenhao Decoction Combined with Praziquantel Ameliorates Inflammation and Hepatic Fibrosis in Schistosoma japonicum-Infected Mice	6
Small Extracellular Vesicles Secreted by Peri-urethral Tissues Regulate Fibroblast Function and Contribute to the Pathogenesis of Female Stress Urinary Incontinence	6
Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation	6
Interplay Between Vestibular Dysfunction and Sleep Disorders	6
Partial Regulation of Ketone Metabolism by Hypoxia in H9C2 Cardiomyocytes	6
Modified Closed Reduction and Percutaneous Kirschner Wires Internal Fixation for Treatment of Supracondylar Humerus Fractures in Children	6
Salidroside Enhances the Sensitivity of Lung Cancer Cells to Paclitaxel by Regulating the Wnt/β-catenin Signaling Pathway	6
Long Non-coding RNA PCED1B Antisense RNA 1 Promotes Cell Proliferation and Invasion in Hepatocellular Carcinoma by Regulating the MicroRNA-34a/CD44 Axis	6
Immp2l Mutation Induces Mitochondrial Membrane Depolarization and Complex III Activity Suppression after Middle Cerebral Artery Occlusion in Mice	6
A Novel ATM Antisense Transcript ATM-AS Positively Regulates ATM Expression in Normal and Breast Cancer Cells	6
ELMOD2 Overexpression Predicts Adverse Outcomes and Regulates Tumor Progression in Gliomas	6
Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis	5
Intraperitoneal and Extraperitoneal Pringle Hepatic Hilar Occlusion in Laparoscopic Liver Resection: A Prospective Randomized Controlled Study	5
Chemotherapy-Induced Myelosuppression in Esophageal Cancer Patients: Risks and Suggestions for Its Management	5
LncRNA H19 Activates the RAS-MAPK Signaling Pathway via miR-140-5p/SOS1 Axis in Malignant Liver Tumors	5
Increased Prevalence of Thyroid Nodules Across Nearly 10 Years in Shanghai, China	5
Efficacy of Children Neuropsychological and Behavioral Scale in Screening for Autism Spectrum Disorders through a Combination of Developmental Surveillance	5
HFD-exacerbated Metabolic Side Effects of Olanzapine Are Suppressed by ER Stress Inhibitor	5
Expert Consensus on Cognitive Dysfunction in Diabetes	5
Migraine and Cochlear Symptoms	5
Editorial Commentary: Association of Comorbid Asthma and the Efficacy of Bioabsorbable Steroid-eluting Sinus Stents Implanted after Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis wit	5
Lindqvist-type Polyoxometalates Act as Anti-breast Cancer Drugs via Mitophagy-induced Apoptosis	5
Associations of Gestational Diabetes Mellitus and Excessive Gestational Weight Gain with Offspring Obesity Risk	5
ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/β-Catenin Signaling Pathway	5
Transarterial Chemoembolization Combined with Apatinib for Treatment of Advanced Hepatocellular Carcinoma: Analysis of Survival and Prognostic Factors	5
Neoadjuvant Immunotherapy for Head and Neck Squamous Cell Carcinoma: Expecting Its Application in Temporal Bone Squamous Cell Carcinoma	5
From Diabetes to Diabetic Complications: Role of Autophagy	5
The 2010–2020 National Natural Science Foundation of China: Radiation Therapy	5
Early Aerobic Exercise Promotes Neurological Function Recovery of Rats after Cerebral Ischemia/Reperfusion by Upregulating the Expression of Heat Shock Protein A5	5
Naringin and Naringenin: Potential Multi-Target Agents for Alzheimer’s Disease	5
Establishment of FAP-overexpressing Cells for FAP-targeted Theranostics	5
Inhibitory Effect of PPARδ Agonist GW501516 on Proliferation of Hypoxia-induced Pulmonary Arterial Smooth Muscle Cells by Regulating the mTOR Pathway	5
Effects of Custom-made Insoles on Plantar Biomechanics and Upper Extremity Muscle Performance	5
Association of ZWINT Expression with Clinicopathologic Characteristics and Prognosis in Breast Cancer Patients	5
Porphyromonas gingivalis Induces Chronic Kidney Disease through Crosstalk between the NF-κB/NLRP3 Pathway and Ferroptosis in GMCs	4
KLF4 Inhibits the Activation of Human Hepatic Stellate Cell In Vitro	4
Effects of Norepinephrine on Renal Cortical and Medullary Blood Flow in Atherosclerotic Rabbits	4
Integration of Artificial Intelligence, Blockchain, and Wearable Technology for Chronic Disease Management: A New Paradigm in Smart Healthcare	4
NEP1-40 Regulates the Development of Hippocampal Neural Stem Cells in Schizophrenic Mice	4
Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening	4
High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1	4
Effects of Exosomes from Menstrual Blood-derived Stem Cells and Ginger on Endometriotic Stem Cells	4
Machine Learning-Based Mortality Prediction for Acute Gastrointestinal Bleeding Patients Admitted to Intensive Care Unit	4
Endoplasmic Reticulum Stress-induced Endothelial Dysfunction Promotes Neointima Formation after Arteriovenous Grafts in Mice on High-fat Diet	4
A Novel Low Air Pressure-Assisted Approach for the Construction of Cells-Decellularized Tendon Scaffold Complex	4
Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases	4
Adjuvant Chemotherapy versus Radiotherapy in High-risk, Early-stage Endometrioid Endometrial Carcinoma	4
Association between Serum Ferritin Levels and Metabolic-associated Fatty Liver Disease in Adults: a Cross-sectional Study Based on the NHANES	4
CASC15 Gene Polymorphisms and Glioma Susceptibility in Chinese Children	4
Dual-Stream Attention-Based Classification Network for Tibial Plateau Fractures via Diffusion Model Augmentation and Segmentation Map Integration	4
Extracts of Bauhinia Championii Alleviate Acute Neuronal Injury After Ischemic Reperfusion by Improving Endoplasmic Reticulum Stress-Mediated Neuronal Apoptosis	4
Protective Effect of Human Umbilical Cord Mesenchymal Stem Cells in Glucocorticoid-induced Osteonecrosis of Femoral Head	4
Development and Validation of a Nomogram Prediction Model for Sepsis-Induced Coagulopathy: A Multicenter Retrospective Study	4
Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma	4
Scientific Hepatectomy for Hepatocellular Carcinoma	4
Modified Glucose-insulin-potassium Therapy for Hemorrhage-induced Traumatic Cardiac Arrest in Rabbits	4
FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition	4
Nucleus Pulposus Cells from Calcified Discs Promote the Degradation of the Extracellular Matrix through Upregulation of the GATA3 Expression	4
High Expression of Fibronectin 1 Predicts a Poor Prognosis in Glioblastoma	4
Long-term Therapeutic Outcome and Prognostic Factors of Patients with Nasopharyngeal Carcinoma Receiving Intensity-modulated Radiotherapy: An Analysis of 608 Patients from Low-endemic Regions of China	4
Nutritional Assessment Tools for Patients with Cancer: A Narrative Review	4
Causal Association Between Tea Consumption and Gout: A Mendelian Randomization Study	4
Kaempferol Improved Rheumatoid Arthritis by Regulating the Immune Imbalance of Treg/Th17	4
Clinical Application of Double Ovulation Stimulation in Patients with Diminished Ovarian Reserve and Asynchronous Follicular Development Undergoing Assisted Reproduction Technology	4
Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage	4
Avocado Oil: Recent Advances in Its Anti-diabetic Potential	4
Guben Tongluo Formula Protects LPS-induced Damage in Lamina Propria B Lymphocytes Through TLR4/MyD88/NF-κB Pathway	4
Impact of Helicobacter pylori Eradication on Clinical and Laboratory Parameters in Non-alcoholic Fatty Liver Disease Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials	4
ANP Increases Zn2⁺ Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts	4
Microrna-1224-5p Is a Potential Prognostic and Therapeutic Biomarker in Glioblastoma: Integrating Bioinformatics and Clinical Analyses	4