Virulence

Article	Citations
Increasing evidence of human infections by the neurotropic Borna disease virus 1 (BoDV-1)	233
A. caviae infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner	199
Dry eye disease caused by viral infection: Past, present and future	138
Immunogenicity and vaccine efficacy of Actinobacillus pleuropneumoniae -derived extracellular vesicles as a novel vaccine candidate	109
Decarboxylase mediated oxalic acid metabolism is important to antioxidation and detoxification rather than pathogenicity in Magnaporthe oryzae	86
The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target	83
Restriction of mitochondrial oxidation of glutamine or fatty acids enhances intracellular growth of Mycobacterium abscessus in macrophages	82
Porphyromonas gulae and canine periodontal disease: Current understanding and future directions	76
Physiological role of bicarbonate in microbes: A double-edged sword?	75
Bacterial metabolism in the host and its association with virulence	72
The role of HDAC6 in enhancing macrophage autophagy via the autophagolysosomal pathway to alleviate legionella pneumophila-induced pneumonia	67
High Child-Pugh and CRUB65 scores predict mortality of decompensated cirrhosis patients with COVID-19: A 23-center, retrospective study	65
Measles virus: Continued outbreaks while striving for eradication	60
Genome-wide characterization of structure variations in the Xiang pig for genetic resistance to African swine fever	55
SARS-CoV-2 in companion animals: Do levels of SARS-CoV-2 seroconversion in pets correlate with those of pet’s owners and with protection against subsequent SARS-CoV-2 infection?	53
Simulating the clinical manifestations and disease progression of human sepsis: A monobacterial injection approach for animal modeling	51
Identification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis	47
Pathogenicity and virulence of Borrelia burgdorferi	44
Outer membrane vesicles from genetically engineered Salmonella enterica serovar Typhimurium presenting Helicobacter pylori antigens UreB a	44
Platelet-derived major histocompatibility complex class I coating on Treponema pallidum attenuates natural killer cell lethality	43
Hepatic and extrahepatic metabolic modulation in hbv-related decompensated cirrhosis and acute-on-chronic liver failure	43
Usingin vivotranscriptomics and RNA enrichment to identify genes involved in virulence ofCandida glabrata	43
Complement evasion factor (CEF), a novel immune evasion factor of Streptococcus pyogenes	43
sRNA23, a novel small RNA, regulates to the pathogenesis ofStreptococcus suisserotype 2	41
Convergent and divergent roles of the glucose-responsive kinase SNF4 in Candida tropicalis	41

Calcineurin-mediated intracellular organelle calcium homeostasis is required for the survival of fungal pathogens upon extracellular calcium stimuli	40
Microbiome analysis reveals the inducing effect of Pseudomonas on prostatic hyperplasia via activating NF-κB signalling	40
MERS-CoV nsp1 impairs the cellular metabolic processes by selectively downregulating mRNAs in a novel granules	40
Adaptor complex-mediated trafficking of Newcastle disease virus fusion protein is regulated by the YLMY motif of its cytoplasmic tail	40
Role of non-coding RNAs in the pathogenesis of viral myocarditis	39
Acute hepatitis of unknown origin in children: Should we move the discussion from a purely infectious origin also to other plausible causes?	38
Repurposing of auranofin and honokiol as antifungals against Scedosporium species and the related fungus Lomentospora prolificans	38
Antibiotics daptomycin interacts with S protein of SARS-CoV-2 to promote cell invasion of Omicron (B1.1.529) pseudovirus	37
Oropouche virus: Understanding “sloth fever” disease dynamics and novel intervention strategies against this emerging neglected tropical disease	36
Screening optimal DC-targeting peptide to enhance the immune efficacy of recombinant Lactobacillus expressing RHDV VP60	35
Pathogenicity and virulence of O’nyong-nyong virus: A less studied Togaviridae with pandemic potential	35
Reduction of endotoxicity in Bordetella bronchiseptica by lipid A engineering: Characterization of lpxL1 and pagP mutants	35
Emergence of Staphylococcus argenteus in pediatrics: Molecular insights from a hospital in East China	34
Synergy of alanine and gentamicin to reduce nitric oxide for elevating killing efficacy to antibiotic-resistant Vibrio alginolyticus	33
Letter to the editor (response to Vajro and colleagues)	32
Insect hypovirulence-associated mycovirus confers entomopathogenic fungi with enhanced resistance against phytopathogens	31
The Hog1-Nmd5 signaling pathway regulates asexual development, lipid metabolism, stress response, trap morphogenesis, and secondary metabolism of Arthrobotrys oligospora	31
Study of the relationships among known virulence genes, coccoid transformation and cytotoxicity of Helicobacter pylori in different clinical diseases	31
The highly pathogenic strain of porcine deltacoronavirus disrupts the intestinal barrier and causes diarrhea in newborn piglets	31
DIM5/KMT1 controls fungal insect pathogenicity and genome stability by methylation of histone H3K4, H3K9 and H3K36	30
A novel transcription factor UvCGBP1 regulates development and virulence of rice false smut fungus Ustilaginoidea virens	29
Genetic architecture of transmission stage production and virulence in schistosome parasites	28
Study of the host specificity of PB1-F2-associated virulence	28
Transcriptional response ofAspergillus fumigatusto copper and the role of the Cu chaperones	28
Pathogenicity and virulence of hepatitis A virus	28
Functional analysis of seven regulators of G protein signaling (RGSs) in the nematode-trapping fungus Arthrobotrys oligospora	27
Establishing an invertebrate Galleria mellonella greater wax moth larval model of Neisseria gonorrhoeae infection	27
Mycoplasma ovipneumoniae induces caspase-8-dependent extrinsic apoptosis and p53- and ROS-dependent intrinsic apoptosis in murine alveolar macrophages	26
Deciphering of Candida parapsilosis induced immune response in Drosophila melanogaster	26
Attenuation of porcine deltacoronavirus disease severity by porcine reproductive and respiratory syndrome virus coinfection in a weaning pig model	26
Site-specific SUMOylation of viral polymerase processivity factor: a way of localizingtoND10 subnuclear domains for restricted and self-controlled reproduction of herpesvirus	25
Presence and function of Hbl B’, the fourth protein component encoded by the hbl operon in Bacillus cereus	24
Too young to die? How aging affects cellular innate immune responses to influenza virus and disease severity	24
Set1-mediated H3K4 methylation is required for Candida albicans virulence by regulating intracellular level of reactive oxygen species	23
The antimicrobial systems of Streptococcus suis promote niche competition in pig tonsils	23
Whole genome analysis unveils genetic diversity and potential virulence determinants in Vibrio parahaemolyticus associated with disease outbreak among cultured Litopenaeus vannamei (Paci	23
The endoplasmic reticulum stress-mediated unfolded protein response protects against infection of goat endometrial epithelial cells byTrueperella pyogenesvia autophagy	23
Candida auris infections in China	22
Recombination events drives the emergence of Colombian Helicobacter pylori subpopulations with self-identity ancestry	22
Identification of two novel HIV-1 circulating recombinant forms of CRF111_01C and CRF116_0108 in southwestern Yunnan, China	22
A new gene family (BAPs) of Cotesia bracovirus induces apoptosis of host hemocytes	22
Sucrose non-fermenting protein kinase gene UvSnf1 is required for virulence in Ustilaginoidea virens	21
Inhibition of cell proliferation by Tas of foamy viruses through cell cycle arrest or apoptosis underlines the different mechanisms of virus–host interactions	21
Identification of miRnas with possible prognostic roles for HAM/TSP	21
The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses	21
Comparative transcriptome combined with morphophysiological analyses revealed the molecular mechanism underlying Tetrahymena thermophila predation-induced antiphage defense in Aeromonas hydr	21
Streptococcus pyogenes emm 98.1 variants activate inflammatory caspases in human neutrophils	20
The enzyme activity of sortase A is regulated by phosphorylation in Staphylococcus aureus	20
Noninvasive diagnosis of significant liver inflammation in patients with chronic hepatitis B in the indeterminate phase	20
The long noncoding RNA loc107053557 acts as a gga-miR-3530-5p sponge to suppress the replication of vvIBDV through regulating STAT1 expression	20

ATP synthase subunit ATP5B interacts with TGEV Nsp2 and acts as a negative regulator of TGEV replication	20
N-acetylcysteine promotes doxycycline resistance in the bacterial pathogen Edwardsiella tarda	19
Analysis of the virulence, infection process, and extracellular enzyme activities of Aspergillus nomius against the Asian corn borer, Ostrinia furnacalis<	19
Helicobacter pylori East Asian type CagA hijacks more SHIP2 by its EPIYA-D motif to potentiate the oncogenicity	19
HylS’, a fragment of truncated hyaluronidase of Streptococcus suis , contributes to immune evasion by interaction with host complement factor C3b	19
The F 1 F o -ATP synthase α subunit of Candida albicans induces inflammatory responses by controlli	19
Maternal and neonatal outcomes and clinical laboratory testing of pregnant women with COVID-19 during the BA.5.2/BF.7 surge	18
YjbH contributes to Staphylococcus aureus skin pathology and immune response through Agr-mediated α-toxin regulation	18
Ixchiq (VLA1553): The first FDA-approved vaccine to prevent disease caused by Chikungunya virus infection	18
Functional dissection of prenyltransferases reveals roles in endocytosis and secretory vacuolar sorting in type 2-ME49 strain of Toxoplasma gondii	18
Correction	18
M1-type polarized macrophage contributes to brain damage through CXCR3.2/CXCL11 pathways after RGNNV infection in grouper	18
The host protein CALCOCO2 interacts with bovine viral diarrhoea virus Npro, inhibiting type I interferon production and thereby promoting viral replication	18
Progress and prospect of polysaccharides as adjuvants in vaccine development	18
LRRC8A promotes Glaesserella parasuis cytolethal distending toxin-induced p53-dependent apoptosis in NPTr cells	18
Dual roles of exostosin glycosyltransferase 1 in Zika virus infection	17
Oral administration of Clostridium butyricum rescues streptomycin-exacerbated respiratory syncytial virus-induced lung inflammation in mice	17
Complement receptor 3 mediatesAspergillus fumigatusinternalization into alveolar epithelial cells with the increase of intracellular phosphatidic acid by activating FAK	17
Knowns and unknowns of TiLV-associated neuronal disease	17
Identification of the RNA-binding domain-containing protein RbpA that acts as a global regulator of the pathogenicity of Streptococcus suis serotype 2	17
Understanding the prevalence of SARS-CoV-2 (COVID-19) exposure in companion, captive, wild, and farmed animals	17
Pathogenesis and virulence of Heartland virus	16
Pathogenicity and virulence of Hepatitis B virus	16
In vitro co-culture of Fasciola hepatica newly excysted juveniles (NEJs) with 3D HepG2 spheroids permits novel investigation of host–parasite interactions	16
RIOK3-Mediated Akt phosphorylation facilitates synergistic replication of Marek’s disease and reticuloendotheliosis viruses	16
Pathogenicity and virulence of Clostridium perfringens	16
Orientin mediates protection against MRSA-induced pneumonia by inhibiting Sortase A	16
Pathogenicity and virulence of henipaviruses	16
Pathogenicity and virulence of influenza	16
Talaromyces marneffei activates the AIM2-caspase-1/-4-GSDMD axis to induce pyroptosis in hepatocytes	16
Exploring the causal role of pathogen-derived antibodies in major urinary and kidney diseases: Insights from generalized summary data-based Mendelian randomization	15
Unraveling the interplay between unicellular parasites and bacterial biofilms: Implications for disease persistence and antibiotic resistance	15
Oral inoculation of Fusobacterium nucleatum exacerbates ulcerative colitis via the secretion of virulence adhesin FadA	15
Inhibitory effects of a maleimide compound on the virulence factors of Candida albicans	14
COVID-19 adaptive evolution during the pandemic – Implications of new SARS-CoV-2 variants on public health policies	14
Safety and immunogenicity of CoronaVac in healthy adults: A prospective observational multicenter real-world study in Henan Province, China	14
Molecular characterization of extraintestinal and diarrheagenic Escherichia coli blood isolates	14
Unveiling the roles of CaSDH8 in Candida albicans : Implications for virulence and azole resistance	14
Loss and gain of ceftazidime-avibactam susceptibility in a non-carbapenemase-producing K1-ST23 hypervirulent Klebsiella pneumoniae	14
The arginine/ornithine binding protein ArgT plays an essential role in Brucella neotomae / Brucella melitensis to prevent intracellular ki	14
A Colletotrichum fructicola dual specificity phosphatase CfMsg5 is regulated by the CfAp1 transcription factor during oxidative stress and promotes virulence on	14
Plant pathogens provide clues to the potential origin of bat white-nose syndrome Pseudogymnoascus destructans	13
Immunosuppressants exert antiviral effects against influenza A(H1N1)pdm09 virus via inhibition of nucleic acid synthesis, mRNA splicing, and protein stability	13
Helicobacter pylori GmhB enzyme involved in ADP-heptose biosynthesis pathway is essential for lipopolysaccharide biosynthesis and bacterial virulence	13
The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens	13
Coincidence of antibodies against Hwp1 and ASCA, two distinct molecular targets of Candida albicans , reinforces the link between this fungal species and coeliac disease	13
Recombination and amino acid point mutations in VP3 exhibit a synergistic effect on increased virulence of rMDPV	13
HIF-1α interacting with miR-2013-3p regulates pathogen-induced energy production changes via targeting glutamate dehydrogenase in the sea urchin Strongylocentrotus intermedius	13
Emergence and circulation of enterovirus B species in infants in southern China: A multicenter retrospective analysis	13
Integrin αVβ3 mediates porcine deltacoronavirus infection and inflammatory response through activation of the FAK-PI3K-AKT-nf-κB signalling pathway	13
Escherichia coli and HPV16 coinfection may contribute to the development of cervical cancer	13
Deletion of N-acetylmuramyl-L-alanine amidases alters the host immune response to Mycobacterium tuberculosis infection	12
LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination	12
Extracellular trap can be trained as a memory response	12
The Salmonella virulence protein PagN contributes to the advent of a hyper-replicating cytosolic bacterial population	12
A phage protein-derived antipathogenic peptide that targets type IV pilus assembly	12
Sequence variations in the ETEC CS6 operon affect transcript and protein expression	12
Association of follicular helper T and follicular regulatory T cells with severity and hyperglycemia in hospitalized COVID-19 patients	12
Host combats porcine reproductive and respiratory syndrome virus infection at non-coding RNAs level	12
Helicobacter pylori cholesterol-α-glucosyltransferase manipulates cholesterol for bacterial adherence to gastric epithelial cells	12
Functionality of the human antibody response to Candida albicans	12
Developmental consequences of children born from mothers with telbivudine treatment during late pregnancy: A prospective study with 3-year follow-up	12
An iron-chelating sulfonamide identified from Drosophila-based screening for antipathogenic discovery	11
Hepatitis B virus middle surface antigen loss promotes clinical variant persistence in mouse models	11
Guanylate-Binding protein 2b regulates the AMPK/mTOR/ULK1 signalling pathway to induce autophagy during Mycobacterium bovis infection	11
Host cell transcriptomic response to the multidrug-resistant Mycobacterium tuberculosis clonal outbreak Beijing strain reveals its pathogenic features	11
Comparative transcriptomic analysis reveal genes involved in the pathogenicity increase of Streptococcus suis epidemic strains	11
H1N1 influenza virus dose dependent induction of dysregulated innate immune responses and STAT1/3 activation are associated with pulmonary immunopathological damage	11
Circulation, genomic characteristics, and evolutionary dynamics of class I Newcastle disease virus in China	11
Oral vaccination with recombinant Lactobacillus casei expressing Aeromonas hydrophila Aha1 against A. hydrophila infections in common carps	11
Regulation of host factor γ-H2AX level and location by enterovirus A71 for viral replication	11
The optimal interval before receiving SARS-COV-2 vaccination for patients who have received Anti-CD 20 monoclonal antibodies	11
Cyclin-dependent kinase 5 negatively regulates antiviral immune response by disrupting myeloid differentiation primary response protein 88 self-association	11
Set2 family regulates mycotoxin metabolism and virulence via H3K36 methylation in pathogenic fungus Aspergillus flavus	11
Development and multimodal characterization of an elastase-induced emphysema mouse disease model for the COPD frequent bacterial exacerbator phenotype	11
Evaluation of the immunogenicity of auxotrophic Lactobacillus with CRISPR-Cas9D10A system-mediated chromosomal editing to express porcine rotavirus capsid protein VP4	11
RPLP1, an NS4B-interacting protein, enhances production of CSFV through promoting translation of viral genome	11
Vaccination inducing durable and robust antigen-specific Th1/Th17 immune responses contributes to prophylactic protection against Mycobacterium avium infection but is ineffective as an adjunct	11
Extracellular vesicles in bacterial and fungal diseases – Pathogenesis to diagnostic biomarkers	11
Mycobacterium tuberculosis protein MoxR1 enhances virulence by inhibiting host cell death pathways and disrupting cellular bioenergetics	11

A novel aquaporin Aagp contributes to Streptococcus suis H 2 O 2 efflux and virulence	11
ABO blood group is involved in the quality of the specific immune response anti-SARS-CoV-2	11