Aging and Disease

Article	Citations
Burn Injuries Accelerate Biological Aging and Increase the Epigenetically Inferred Risk of Mortality and Frailty	113
Aligning Intrinsic Capacity and Geroscience: Linking Function with Biology	112
Revisiting the Role of Mitochondrial DNA Mutations in Aging: Bridging Theoretical Expectations with Empirical Observations	112
Vascular Contributions to Healthy Aging and Dementia	81
Correlations between Aging, Telomeres, and Natural Compounds	81
The HLA-B*57:01 Haplotype, Genetic Key Linking Innate Immunity and Longevity	74
Neuropsychological Profiles in Genetic Frontotemporal Dementia: A Meta-Analysis and Systematic Review	71
Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies	67
Vascular Aging and Atherosclerosis: A Perspective on Aging	62
Neuronal Intranuclear Inclusion Disease with NOTCH2NLC GGC Repeat Expansion: A Systematic Review and Challenges of Phenotypic Characterization	61
Updates in Intravenous Thrombolysis Treatment for Acute Ischemic Stroke in Asian Populations	60
KRT5+/p63+ Stem Cells Undergo Senescence in the Human Lung with Pathological Aging	56
Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine	55
Exploiting the Fractionation of Stable Isotopes in Biochemical Processes for Medical Diagnosis: A Narrative Review	54
Quantum Sensing for Precision Organ Aging Assessment	53
Retinal Pigment Epithelium Phagocytosis and Retinal Degenerative Diseases	52
Cross-Tissue Proteomic Mendelian Randomization Identifies Therapeutic Targets for Vascular Dementia	52
The Dickkopf Protein Family in Non-Neoplastic Disorders: Emerging Roles and Therapeutic Targeting	50
Astrocytic Ferroptosis: An Integrative Hub Linking Metabolic Dyshomeostasis, Glial Crosstalk, and Neurodegeneration in Alzheimer’s Disease	50
Metabolic Dysregulation in Parkinson’s Disease: Non-Oxidative Phosphorylation and Its Role in Brain Energy Metabolism	48
Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies	47
The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung	47
The Roles of T cells in Immune Checkpoint Inhibitor-Induced Arthritis	47
A Systematic Review of Intervention Trials Utilizing Biomarkers Among Informal Caregivers of People with Alzheimer's Disease & Related Dementias	46
Axonal Energy Crisis and Calcium Phosphate Dysregulation as Pathogenesis of Optic Disc Drusen	46

Lysine Malonylation and Its Links to Metabolism and Diseases	46
Unmet Medication Needs and the Association with Mortality in Older Adults: Equality-Oriented Monitoring toward Universal Health Coverage	45
Early Risk Prediction Model for Stroke-Heart Syndrome Following Endovascular Therapy	45
Normal Bone Matrix Mineralization but Altered Growth Plate Morphology in the LmnaG609G/G609G Mouse Model of Progeria	45
Apolipoprotein CII: Cornerstone of Pathophysiological Interplay in Aortic Stenosis and type 2 Diabetes Mellitus	43
VCAM-1 in Cognitive Impairment: Mechanisms, Biomarker Potential, and Therapeutic Targeting	42
Age-, sex-, and ancestry-specific prevalence of hearing loss in UK Biobank and All of Us Research Program	42
Mitochondrial Dysfunction of Astrocytes Mediates Lipid Accumulation in Temporal Lobe Epilepsy	41
Overcoming Extracellular Matrix Barriers: Biomaterial-Assisted microRNA Delivery for Fibrous Musculoskeletal Regeneration	40
Spinal Cord Injury and Ageing: The Role of Chronic Neuroinflammation	39
Stroke-Induced Retinal Dysfunction: Mechanisms, Diagnostics, and Future Directions	37
Aβ Deposition in Extracellular Space Disrupts Glial-Neuron Communication and Triggers Alzheimer's Disease	37
Immunosenescence: Shaping the Hematological Narrative in the Era of Aging	36
Endogenous Retroviruses Unveiled: A Comprehensive Review of Inflammatory Signaling/Senescence-Related Pathways and Therapeutic Strategies	36
Beyond Amyloid: Rethinking the Foundations of Alzheimer’s Disease Pathogenesis and Therapy	36
Role of AMPK and Sirtuins in Aging Heart: Basic and Translational Aspects	36
Exosomal Proteomics: Unveiling Novel Insights into Lung Cancer	35
Neuroinflammation as a Link in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis	35
Role of Serotonylation and SERT Posttranslational Modifications in Alzheimer's Disease Pathogenesis	34
EchoAGE: Echocardiography-based Neural Network Model Forecasting Heart Biological Age	33
Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy	33
Dopamine-Induced L-Lactate Production in Cortical Astrocytes Cross-Reacts with β1-Adrenoceptor-Mediated cAMP Signalling	33
Autophagy in Disease Onset and Progression	33
Microcirculation Dysfunction in Subacute Stroke: The Role of Delayed Capillary Pericyte Loss	32
Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity via AMPK/SOD2 Pathway	32
Telomeres: Dysfunction, Maintenance, Aging and Cancer	32
Aging and “Age-Related” Diseases - What Is the Relation?	30
Epigenetic Clocks Identify Harmful Epigenetic Aging Linked to Depression Severity and Cognitive Deficits in Major Depressive Disorder	30
Multimodal In Vivo Imaging Reveals BZBS Capsules Enhance Brain Function and Delay Aging in the Mouse Models	29
(Dys)regulation of the Immune System in Parkinson’s Disease: Methodologies, Techniques, and Key Findings from Human Studies	29
SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease	29
Clinical Potential of Immunotherapies in Subarachnoid Hemorrhage Treatment: Mechanistic Dissection of Innate and Adaptive Immune Responses	29
Advancing Single-Cell Transcriptomic Analysis to Reveal Age-Related Skeletal Muscle Changes: A Systematic Review	28
The Comorbidity of AD and PD: Exploring Clinical, Pathological, and Biomarker Interactions	28
Single Cell RNAseq Analysis of Thyroid Hormone Effects on Retinal Glial Cells	28
Revisiting Skeletal Muscle Dysfunction and Exercise in Chronic Obstructive Pulmonary Disease: Emerging Significance of Myokines	27
Histone Methylation, Energy Metabolism, and Alzheimer's Disease	27
Applications of Chitosan and its Derivatives in the Treatment of Osteoarthritis	26
Semaphorins: Missing Signals in Age-dependent Alteration of Neuromuscular Junctions and Skeletal Muscle Regeneration	26
Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging	25
Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential	24
Mortality Outcomes in a Large Population with and without Covert Cerebrovascular Disease	24
Elderly Dementia Needs Better Care in Post-COVID-19 Era	24
Epidural Pulsation Accelerates the Drainage of Brain Interstitial Fluid	24
NAD+ Metabolism and Mitochondrial Activity in the Aged Oocyte: Focus on the Effects of NAMPT Stimulation	23
New Clues to Cardiovascular Disease: Erythrocyte Lifespan	23
Role of Microglia, Decreased Neurogenesis and Oligodendrocyte Depletion in Long COVID-Mediated Brain Impairments	23
Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency	22
Visual Dependence in Postural Control Is Increased in Older Adults	22
Different Aspects of Aging in Migraine	22

Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice	21
Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions	21
Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside	20
Minocycline Administration Does Not Have an Effect on Retinal Ganglion Cell Survival in a Murine Model of Ocular Hypertension	20
Mechanistic Insights and Emerging Therapeutic Targets of Alzheimer's Disease: From the Perspective of Inter-Organ Crosstalk	20
Nuclear Protein Aggregates Disrupt RNA Processing and Alter Biomechanics in a Muscle Cell Model of OPMD	20
Targeting Mitochondrial Sirtuins in Age-Related Neurodegenerative Diseases and Fibrosis	19
Expanding on Gut Microbiota Insights in Sarcopenia and Osteoporosis	19
A Signature of Senescence Based on An Analysis of Selected Markers in Primary Vascular Smooth Muscle Cells Cultured In Vitro and Derived from Atherosclerotic Plaque	19
Stroke Exacerbates Respiratory Disorder and Cognition Impairment in Mice with Cerebral Amyloid Angiopathy	19
Emerging Roles of Adaptive Immune Response in Alzheimer's Disease	19
The Lung-Brain Axis in Cognitive Impairment and Dementia: Mechanisms and Therapeutic Prospects	19
Hexokinase as a Central Hub in Neurodegeneration: From Metabolic Dysfunction to Therapeutic Innovation	19
Irisin: A Potentially Fresh Insight into the Molecular Mechanisms Underlying Vascular Aging	18
Potential of Neuroinflammation-Modulating Strategies in Tuberculous Meningitis: Targeting Microglia	18
Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice	18
Biomarkers of Parkinson’s Disease: From Basic Research to Clinical Practice	18
Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training	18
Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects	18
Health Related Quality of Life in Adults with 13 Chronic Diseases before Age 65 and after Age 65 Using Fuzzy Rough Analysis of SF-36 Domains	18
Senescent T Cells in Age-Related Diseases	18
A Standardized Protocol for Mouse Longevity Studies in Preclinical Drug Development	18
Astrocyte-Derived Extracellular Vesicles for Ischemic Stroke: Therapeutic Potential and Prospective	17
Metformin Treatment Leads to Increased HIV Transcription and Gene Expression through Increased CREB Phosphorylation and Recruitment to the HIV LTR Promoter	17
The Interplay Between Physical Exercise, Nutritional Strategies, and Brain-Derived Neurotrophic Factor in Promoting Cognitive Performance	17
Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency	17
The Emerging Role of the Mitochondrial Respiratory Chain in Skeletal Aging	17
Identification of Cathepsin B as a Therapeutic Target for Ferroptosis of Macrophage after Spinal Cord Injury	16
Conceptual Overview of Biological Age Estimation	16
Advancing Neurological Health: Insights into Aging, Immunity, and Vascular Dynamics	16
Circadian Rhythm, Clock Genes and Osteoarthritis: The Dream of a Good Night’s Sleep	16
The Role of Liquid-Liquid Phase Separation in the Accumulation of Pathological Proteins: New Perspectives on the Mechanism of Neurodegenerative Diseases	16
CAG Repeat Expansions Increase N1-Methyladenine to Alter TDP-43 Phase Separation: Lights Up Therapeutic Intervention for Neurodegeneration	16
Probiotic Limosilactobacillus Reuteri (Lactobacillus Reuteri) Extends the Lifespan of Drosophila Melanogaster through Insulin/IGF-1 Signaling	16
Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43	16
Oligomeric β-Amyloid Suppresses Hippocampal γ-Oscillations through Activation of the mTOR/S6K1 Pathway	16
Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke	16
Prolonged Mild Sleep Restriction Changes Epigenome-Wide DNA Methylation in Peripheral Blood Cells: A Randomized Crossover Trial	15
Perspectives on Pathological Crosstalk between Malocclusion and Multi-organ Systems: The Hidden Face of an Iceberg	15
Aging Intensifies Myeloperoxidase Activity after Ischemic Stroke	15
Establishing Predictors of Acute Sarcopenia: A Proof-Of-Concept Study Utilising Network Analysis	15
Engineering the Future of Longevity R&D: The Case for AI-Driven, Integrated Biotechnology Ecosystems	15
Redefinition of Synovial Fibroblasts in Rheumatoid Arthritis	14
Ovariectomy and High Fat-Sugar-Salt Diet Induced Alzheimer's Disease/Vascular Dementia Features in Mice	14
The Greater Omentum: Multifaceted Interactions in Neurological Recovery and Disease Progression	14
Brain Insulin Signaling is Associated with Late-Life Cognitive Decline	14
Resveratrol: Harnessing Nature's Potential for Chronic Pain Relief	14
Bone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways	14
Mitochondria: A Potential Rejuvenation Tool against Aging	14
Crossing Pathological Boundaries: Multi-Target Restoration of the Neurovascular Unit in Alzheimer's and Vascular Dementia—From Modern Therapeutics to Traditional Chinese Medicine	14
Association Between Dementia and Optical Coherence Tomography Scan Quality	13
Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application	13
Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer’s Disease: A Systematic Review	13
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes	13
Alpha-Glucosidase Inhibitors in Aging and Aging-Related Diseases: Clinical Applications and Relevant Mechanisms	13
Neuronal Senescence in the Aged Brain	13
Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications	13
Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance	13
Interconnected Pathways of Alzheimer's Disease and Osteoporosis: A Review of Genetic, Hormonal, and Environmental Influences	12
Osteoporosis in Relation to a Bone-Related Aging Biomarker Derived from the Urinary Proteomic Profile: A Population Study	12
Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer	12
Critical Considerations for Mesenchymal Stem Cell-based Therapies in Osteoarthritis and Spinal Cord Injury: A Narrative Review	12
Microglial Histaminergic Signaling Promotes Interleukin-10 Production and Ameliorates Motor Dysfunction in Parkinson's Disease	12
Plasma GFAP and Amyloid Pathology Predict Cognitive Response to Multidomain Interventions in MCI	12
Hypoxic Preconditioning Mitigates Acute Hypoxia Induced MS/VDB Cholinergic Cell Loss and Memory Impairments	12
Neurofilament-Light Chain and Glial Fibrillary Acidic Protein as Blood-Based Delirium Risk Markers: A Multicohort Study	12
Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations	12
Spinal cord changes in Neurodegenerative and Neuroinflammatory Diseases	12
Cardiovascular Health, as per Life's Essential 8, and Impaired Lower-Extremity Function in Older Adults	12
Lars2 Deficiency-Induced Mitochondrial Dysfunction Drives the Emergence of a Pro-Inflammatory Stroke-Specific Microglial Subpopulation	12
Mechanisms and Pathogenesis of Diabetic Cognitive Impairment: A Comprehensive Review	12
Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians	12
Male Monocyte-Like Cells are Prone to a Senescence-Induced Pro-inflammatory State	11
Crosstalk between Circadian Rhythm Dysregulation and Tumorigenesis, Tumor Metabolism and Tumor Immune Response	11
Epigenetic Regulation of Regulated Cell Death in Aging-Related Diseases: Clinical Perspectives	11
Aging Gut Microbiome in Healthy and Unhealthy Aging	11
Biological Age Should Anchor Age-Related Disease Research	11
Interthalamic Adhesion as a Potential Structural Regulator of Cerebrospinal Fluid Dynamics in the Third Ventricle	11
Lamotrigine Restores Impairments in Theta Rhythms and LTP as Early Biomarkers of Aβ1-42-Induced Hippocampal Network Dysfunction	11
Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice	11

Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease	11
Age-Related Hormones Changes and Its Impact on Health Status and Lifespan	10
The Role of Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis	10
A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?	10
Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and Modulators	10
Neuroserpin and Extracellular Vesicles in Ischemic Stroke: Partners in Neuroprotection?	10
Responsiveness to Tocilizumab in Anti-Acetylcholine Receptor-Positive Generalized Myasthenia Gravis	10
Changes in Plasma Neutral and Ether-Linked Lipids Are Associated with The Pathology and Progression of Alzheimer’s Disease	10
Inhibiting Glutaminase Exerts Opposite Effects on Ovariectomy-Induced and Age-Related Reductions in Murine Bone Mass	10
Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases	10
Deep Learning Based on Computed Tomography Predicts Response to Chemoimmunotherapy in Lung Squamous Cell Carcinoma	10
Revolutionizing Senescence Detection: Advancements from Traditional Methods to Cutting-Edge Techniques	10
Comprehensive Review of Therapeutic Efficacy and Underlying Mechanisms of Various Exercise Modalities in Treating Osteoporosis	9
Sex- and Age-Dependent Metabolic and Inflammatory Pathways in Cardiomyopathy: The Role of Sirtuins, Inflammaging and Mitochondrial Homeostasis	9
Emerging Roles of Skeletal Muscle-Derived Exosomal miRNAs in Metabolic Regulation: A Perspective	9
A longitudinal Analysis of the Association between Socioeconomic Position and Multimorbidity in the European Prospective Investigation into Cancer and Nutrition Study	9
Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies	9
Metabolic Dysfunction in Idiopathic Intracranial Hypertension: Current Theories and Updates	9
Genetic Risk, Inflammation, and Therapeutics: An Editorial Overview of Recent Advances in Aging Brains and Neurodegeneration	9
nillin Recedes in p53-Dependent Senescence of Tumor Cells and Reappears in Cells Escaping from Senescence	9
Role and Mechanism of Epigenetic Regulation in the Aging of Germ Cells: Prospects for Targeted Interventions	9
Bidirectional Crosstalk between the Heart and Brain in Alzheimer's Disease	9
Optimal Evaluation and Treatment of Cardiac Rehabilitation for Patients Following TAVR: A Personalized Program Based on The Five Prescriptions	9
Unveiling the Relation between Cellular Ageing, Epigenetics and Cancer	9
The α-MSH-MC1R Axis Modulates Sex-Specific Senescence and Inflammation Processes in Human Articular Chondrocytes and Mice Knee Joints	9
Underlying Mechanisms and Treatment of Cellular Senescence-Induced Biological Barrier Interruption and Related Diseases	9
Circadian Rhythm and the Risk of Cardiovascular Diseases: Genetic Evidence	9
Profile for Brain Disease Research Infrastructure for Data Gathering and Exploration (BRIDGE) Platform	9
Traveling Subject-Informed Harmonization Increases Reliability of Brain Diffusion Tensor and Neurite Mapping	9
Differential Effects of Endurance Exercise on Musculoskeletal and Hematopoietic Modulation in Old Mice	8
Aging Biomarkers in Osteoporosis: A Systematic Review of Molecular Mechanisms, Biological Aging, and Population Evidence	8
Islet Inflammation and Endocrine Function in Aging - Evaluating the Role of Toll-like receptor 4	8
Mitochondrial Transfer in the Neurovascular Unit, Not Only for Energy Rescue: A Systematic Review	8
Recent Advances in Aging-Related Diseases: Accelerated Aging, Molecular Mechanisms, Interventions, and Therapies	8
Overexpression of RACGAP1 by E2F1 Promotes Neuroendocrine Differentiation of Prostate Cancer by Stabilizing EZH2 Expression	8
USP7 Inhibits Osteoclastogenesis via Dual Effects of Attenuating TRAF6/TAK1 Axis and Stimulating STING Signaling	8
NeuroD1 Regulated Endothelial Gene Expression to Modulate Transduction of AAV-PHP.eB and Recovery Progress after Ischemic Stroke	8
Diagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis	8
Metabolic-Inflammatory Syndrome: Decoding the Metabolic-Immune Axis for Precision Intervention	8
Risk Factors for Oropharyngeal Dysphagia in Older Adults - Evidence from Consorci Sanitari Del Maresme and Mataró University Hospital, Catalonia, Spain	8
Vascular Aging and Multi-Omic Regulation in Ischemic Stroke: Toward Precision Neurorepair	8
Mesenchymal Stem Cell-Derived Exosomes Promote Recovery of The Facial Nerve Injury through Regulating Macrophage M1 and M2 Polarization by Targeting the P38 MAPK/NF-Κb Pathway	8
CD16-CD56bright NK Cells: A Protective NK Cell Subset for Progression and Prognosis in Amyotrophic Lateral Sclerosis	8
Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses	8
Endothelial Senescence in Neurological Diseases	8
YAP/TAZ as Molecular Targets in Skeletal Muscle Atrophy and Osteoporosis	8