Aging and Disease

Article	Citations
Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives	87
Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke	73
DeepMAge: A Methylation Aging Clock Developed with Deep Learning	72
Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular Degeneration	67
Cellular Senescence in Cardiovascular Diseases: A Systematic Review	60
MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis	52
Acute Stroke Management: Overview and Recent Updates	50
Transcranial Near Infrared Light Stimulations Improve Cognition in Patients with Dementia	48
Extracellular Vesicles for the Diagnosis and Treatment of Parkinson’s Disease	47
Radiomics in Stroke Neuroimaging: Techniques, Applications, and Challenges	47
The Impact of Frailty on Spine Surgery: Systematic Review on 10 years Clinical Studies	46
The Effect of COVID-19-related Lockdowns on Diet and Physical Activity in Older Adults: A Systematic Review	44
Regulatory T cells in COVID-19	44
Mechanism of Ferroptosis: A Potential Target for Cardiovascular Diseases Treatment	43
New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases	43
MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease	42
Metabolomics Signatures of Aging: Recent Advances	41
Blocking C3d+/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke	40
Sleep Disorders in Stroke: An Update on Management	37
Comparative Analysis of Aducanumab, Zagotenemab and Pioglitazone as Targeted Treatment Strategies for Alzheimer’s Disease	36
Neuromodulation in Drug Resistant Epilepsy	35
Human Adipose Mesenchymal Stem Cell-derived Exosomes Protect Mice from DSS-Induced Inflammatory Bowel Disease by Promoting Intestinal-stem-cell and Epithelial Regeneration	33
Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease	32
Mesenchymal Stem Cells for the Compassionate Treatment of Severe Acute Respiratory Distress Syndrome Due to COVID 19	32
Aging and Renal Disease: Old Questions for New Challenges	32

The Molecular Regulation in the Pathophysiology in Ovarian Aging	31
Mammalian AKT, the Emerging Roles on Mitochondrial Function in Diseases	31
Metformin: A Potential Candidate for Targeting Aging Mechanisms	30
Sarcopenic Obesity: An Emerging Public Health Problem	30
NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice	30
Cellular Senescence Affects Cardiac Regeneration and Repair in Ischemic Heart Disease	30
Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases	29
Intrinsic Capacity in Older Adults: Recent Advances	29
Pharmacological Treatment of Vascular Dementia: A Molecular Mechanism Perspective	28
Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection	28
Autophagy and Renal Fibrosis	27
Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal	27
Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a	27
A Unique Type of Highly-Activated Microglia Evoking Brain Inflammation via Mif/Cd74 Signaling Axis in Aged Mice	26
Transcranial Focused Ultrasound Stimulation Improves Neurorehabilitation after Middle Cerebral Artery Occlusion in Mice	26
An Update on Medical and Surgical Treatments of Parkinson’s Disease	26
Irreversibility of Pulmonary Fibrosis	26
NIHSS Consciousness Score Combined with ASPECTS is a Favorable Predictor of Functional Outcome post Endovascular Recanalization in Stroke Patients	26
Intestinal Inflammation and Parkinson’s Disease	25
Clinical Characteristics, Transmissibility, Pathogenicity, Susceptible Populations, and Re-infectivity of Prominent COVID-19 Variants	25
SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases	25
Amyloid Cascade Hypothesis for the Treatment of Alzheimer’s Disease: Progress and Challenges	24
Coagulation Disorders and Thrombosis in COVID-19 Patients and a Possible Mechanism Involving Endothelial Cells: A Review	24
Targeting NLRP3 Inflammasome in the Treatment Of Diabetes and Diabetic Complications: Role of Natural Compounds from Herbal Medicine	24
The Role of SGLT2 Inhibitors in Vascular Aging	24
P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy	24
Emerging Roles of Ceramide in Cardiovascular Diseases	24
A Comprehensive Summary of the Knowledge on COVID-19 Treatment	24
Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson’s Disease	24
Effectiveness and Safety of Traditional Chinese Medicine in Treating COVID-19: Clinical Evidence from China	23
Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction	23
Mitochondrial Quality Control in Sarcopenia: Updated Overview of Mechanisms and Interventions	23
Immune Cell Number, Phenotype, and Function in the Elderly with Sepsis	22
Aquaporin-4 and Cognitive Disorders	22
The Cause of Alzheimer’s Disease: The Theory of Multipathology Convergence to Chronic Neuronal Stress	22
Depression and Dementia in Older Adults: A Neuropsychological Review	22
Tumor Immune Microenvironment and Immunotherapy in Non-Small Cell Lung Cancer: Update and New Challenges	22
HIF-1α promotes the migration and invasion of cancer-associated fibroblasts by miR-210	22
CB2R Attenuates Intervertebral Disc Degeneration by Delaying Nucleus Pulposus Cell Senescence through AMPK/GSK3β Pathway	22
The Applications of Focused Ultrasound (FUS) in Alzheimer’s Disease Treatment: A Systematic Review on Both Animal and Human Studies	22
Pediatric Stroke: Overview and Recent Updates	21
Endogenous Repair and Regeneration of Injured Articular Cartilage: A Challenging but Promising Therapeutic Strategy	21
SARS-CoV-2: the “Uncensored” Truth about Its Origin and Adipose-Derived Mesenchymal Stem Cells as New Potential Immune-Modulatory Weapon	21
Non-alcoholic Fatty Liver Disease and Liver Fibrosis during Aging	21
Ischemic Conditioning Ameliorated Hypertension and Vascular Remodeling of Spontaneously Hypertensive Rat via Inflammatory Regulation	21
Dysfunction of the Blood-brain Barrier in Cerebral Microbleeds: from Bedside to Bench	21
Nilotinib Improves Bioenergetic Profiling in Brain Astroglia in the 3xTg Mouse Model of Alzheimer’s Disease	21
Metabolic Healthy Obesity, Vitamin D Status, and Risk of COVID-19	20
Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington’s Disease	20
A Next-Generation Vaccine Candidate Using Alternative Epitopes to Protect against Wuhan and All Significant Mutant Variants of SARS-CoV-2: An Immunoinformatics Approach	19

VEGF, a Key Factor for Blood Brain Barrier Injury After Cerebral Ischemic Stroke	19
Deficiency of Endothelial Nitric Oxide Synthase (eNOS) Exacerbates Brain Damage and Cognitive Deficit in A Mouse Model of Vascular Dementia	19
ACE2 and COVID-19 Susceptibility and Severity	19
Neuroplastic Effect of Exercise Through Astrocytes Activation and Cellular Crosstalk	19
Animal Models of Epilepsy: A Phenotype-oriented Review	19
Outcomes in Endovascular Therapy for Basilar Artery Occlusion: Intracranial Atherosclerotic Disease vs. Embolism	19
Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity	18
Pharmacological Blockade of NLRP3 Inflammasome/IL-1β-Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction	18
Extracellular Vesicles in Health and Disease	18
Systematic Review of Studies on Telomere Length in Patients with Multiple Sclerosis	18
Global Sex Disparity of COVID-19: A Descriptive Review of Sex Hormones and Consideration for the Potential Therapeutic Use of Hormone Replacement Therapy in Older Adults	18
Aspirin Positively Contributes to Drosophila Intestinal Homeostasis and Delays Aging through Targeting Imd	17
A Systematic Review of Parkinson’s Disease Cluster Analysis Research	17
The Pathogenesis and Treatment of Cardiovascular Autonomic Dysfunction in Parkinson’s Disease: What We Know and Where to Go	17
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice	17
Identification of Molecules Responsible for Therapeutic Effects of Extracellular Vesicles Produced from iPSC-Derived MSCs on Sjo¨gren’s Syndrome	17
Super-Refractory Status Epilepticus: Prognosis and Recent Advances in Management	17
Aging, Social Distancing, and COVID-19 Risk: Who is more Vulnerable and Why?	17
Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke	17
Age-Related Cognitive and Motor Decline in a Mouse Model of CDKL5 Deficiency Disorder is Associated with Increased Neuronal Senescence and Death	17
The Functional Role of Lipoproteins in Atherosclerosis: Novel Directions for Diagnosis and Targeting Therapy	16
SARS-CoV-2 Emergency and Long-Term Cognitive Impairment in Older People	16
Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents	16
Identifying Biomarkers Associated with Venous Infarction in Acute/Subacute Cerebral Venous Thrombosis	16
Age and Gender-related Variations of Molecular and Phenotypic Parameters in A Cohort of Sicilian Population: from Young to Centenarians	16
Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction	16
Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments	16
Extracellular Vesicles as Pro- and Anti-inflammatory Mediators, Biomarkers and Potential Therapeutic Agents in Multiple Sclerosis	16
Scientific Advancements in Drug Development and Trials for Urothelial Carcinoma: Insights From the 2023 ASCO-GU Cancers Symposium	15
Pharmacological Mechanisms and Clinical Applications of Curcumin: Update	15
Skeletal Muscle Metabolic Alternation Develops Sarcopenia	15
Role of Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review	15
The Role of Immune Cells in the Pathogenesis of Idiopathic Inflammatory Myopathies	15
Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena	15
Ferroptosis in Intracerebral Hemorrhage: A Panoramic Perspective of the Metabolism, Mechanism and Theranostics	15
DL-3-n-butylphthalide Increases Collateriogenesis and Functional Recovery after Focal Ischemic Stroke in Mice	15
CD36 Signaling in Diabetic Cardiomyopathy	15
Effects of Antihypertensive Drugs on Cognitive Function in Elderly Patients with Hypertension: A Review	14
Association between Parkinson’s Disease and Diabetes Mellitus: From Epidemiology, Pathophysiology and Prevention to Treatment	14
Rapidly Progressive Dementia with Asymmetric Rigidity Following ChAdOx1 nCoV-19 Vaccination	14
Contrasting Metabolic Insufficiency in Aging and Dementia	14
Pathogenesis and Management in Cerebrovenous Outflow Disorders	14
Role of Matrix Metalloproteinases in Myelin Abnormalities and Mechanical Allodynia in Rodents with Diabetic Neuropathy	14
Metabolic Abnormalities in Patients with Chronic Disorders of Consciousness	14
Lysine Malonylation and Its Links to Metabolism and Diseases	14
Non-Muscular Invasive Bladder Cancer: Re-envisioning Therapeutic Journey from Traditional to Regenerative Interventions	14
cGAS- Stimulator of Interferon Genes Signaling in Central Nervous System Disorders	14
Reflex Epilepsy	14
Brain-derived CCR5 Contributes to Neuroprotection and Brain Repair after Experimental Stroke	14
The Aged Intestine: Performance and Rejuvenation	14
COVID-19 Pandemic and Osteoporosis in Elderly Patients	13
The Role of Kynurenine Pathway and NAD+ Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome	13
Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression	13
Vascular Calcification in Chronic Kidney Disease: An Update and Perspective	13
Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update	13
Oligodendrocyte Precursor Cells Transplantation Improves Stroke Recovery via Oligodendrogenesis, Neurite Growth and Synaptogenesis	13
The NO-cGMP-PKG Axis in HFpEF: From Pathological Mechanisms to Potential Therapies	13
Cell Heterogeneity Uncovered by Single-Cell RNA Sequencing Offers Potential Therapeutic Targets for Ischemic Stroke	13
Risk Factors, Pathophysiologic Mechanisms, and Potential Treatment Strategies of Futile Recanalization after Endovascular Therapy in Acute Ischemic Stroke	13
Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors	13
Traditional Chinese Medicine and Western Medicine Share Similar Philosophical Approaches to Fight COVID-19	13
Organ-differential Roles of Akt/FoxOs Axis as a Key Metabolic Modulator during Aging	13
Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions	13
Therapeutic Potential of Nucleic Acids when Combined with Extracellular Vesicles	13
Limb Remote Ischemic Conditioning Ameliorates Cognitive Impairment in Rats with Chronic Cerebral Hypoperfusion by Regulating Glucose Transport	12
Prediction of SARS-CoV Interaction with Host Proteins during Lung Aging Reveals a Potential Role for TRIB3 in COVID-19	12
Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity via AMPK/SOD2 Pathway	12
SIRT6 in Vascular Diseases, from Bench to Bedside	12
Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy	12
Intestinal Permeability, Dysbiosis, Inflammation and Enteric Glia Cells: The Intestinal Etiology of Parkinson’s Disease	12
Roles of the MYST Family in the Pathogenesis of Alzheimer’s Disease via Histone or Non-histone Acetylation	12
The Mechanism of Physical Activity-induced Amelioration of Parkinson’s Disease: A Narrative Review	12
tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases	12
G. sinense and P. notoginseng Extracts Improve Healthspan of Aging Flies and Provide Protection in A Huntington Disease Model	12
Protective Effects of Exercise Become Especially Important for the Aging Immune System in The Covid-19 Era	12
The Metabolic Landscape in Osteoarthritis	12
Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity	12
Current Animal Model Systems for Ovarian Aging Research	12
Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and Modulators	12
Promising Intervention Approaches to Potentially Resolve Neuroinflammation And Steroid Hormones Alterations in Alzheimer’s Disease and Its Neuropsychiatric Symptoms	11

Are Older People Really More Susceptible to SARS-CoV-2?	11
Neurological and Neurodegenerative Disorders: Novel Concepts and Treatment	11
Astrocyte-Derived Extracellular Vesicles (ADEVs): Deciphering their Influences in Aging	11
TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis	11
Adiponectin and Thyroid Cancer: Insight into the Association between Adiponectin and Obesity	11
Dehydroepiandrosterone, Cancer, and Aging	11
Ischemic Stroke: An Underestimated Complication of COVID-19	11
Coronavirus Disease (COVID-19): A Perspective from Immunosenescence	11
Comprehensive Perspectives on Experimental Models for Parkinson’s Disease	11
Bioenergetic Impairment in the Neuro-Glia-Vascular Unit: An Emerging Physiopathology during Aging	11
Obstructive Sleep Apnea-hypopnea Syndrome as a Novel Potential Risk for Aging	11
Adeno-Associated Virus Expression of α-Synuclein as a Tool to Model Parkinson’s Disease: Current Understanding and Knowledge Gaps	11