Aging and Disease

Article	Citations
Is the β Common Receptor the Key Molecule for the Protective Effect of Erythropoietin?	324
Protein Synthesis Errors and Longevity: A Lesson from a Single Amino Acid Mutation Study	129
Axonal Energy Crisis and Calcium Phosphate Dysregulation as Pathogenesis of Optic Disc Drusen	121
Burn Injuries Accelerate Biological Aging and Increase the Epigenetically Inferred Risk of Mortality and Frailty	119
Updates in Intravenous Thrombolysis Treatment for Acute Ischemic Stroke in Asian Populations	104
Revisiting the Role of Mitochondrial DNA Mutations in Aging: Bridging Theoretical Expectations with Empirical Observations	90
Exploiting the Fractionation of Stable Isotopes in Biochemical Processes for Medical Diagnosis: A Narrative Review	86
Vascular Contributions to Healthy Aging and Dementia	76
The HLA-B*57:01 Haplotype, Genetic Key Linking Innate Immunity and Longevity	75
Retinal Pigment Epithelium Phagocytosis and Retinal Degenerative Diseases	74
Neuropsychological Profiles in Genetic Frontotemporal Dementia: A Meta-Analysis and Systematic Review	70
Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies	70
Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine	69
The Roles of T cells in Immune Checkpoint Inhibitor-Induced Arthritis	62
Metabolic Dysregulation in Parkinson’s Disease: Non-Oxidative Phosphorylation and Its Role in Brain Energy Metabolism	57
EP3 Receptor Deficiency Improves Vascular Remodeling and Cognitive Impairment in Cerebral Small Vessel Disease	57
KRT5+/p63+ Stem Cells Undergo Senescence in the Human Lung with Pathological Aging	56
Neuronal Intranuclear Inclusion Disease with NOTCH2NLC GGC Repeat Expansion: A Systematic Review and Challenges of Phenotypic Characterization	55
Lysine Malonylation and Its Links to Metabolism and Diseases	55
Correlations between Aging, Telomeres, and Natural Compounds	54
Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies	51
Vascular Aging and Atherosclerosis: A Perspective on Aging	49
The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung	48
Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update	48
A Systematic Review of Intervention Trials Utilizing Biomarkers Among Informal Caregivers of People with Alzheimer's Disease & Related Dementias	48

Neuroinflammation as a Link in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis	48
Perspectives on Movement and Eating Behaviours in Brazilian Elderly: An Analysis of Clusters Associated with Disease Outcomes	47
Telomeres: Dysfunction, Maintenance, Aging and Cancer	46
Role of AMPK and Sirtuins in Aging Heart: Basic and Translational Aspects	46
Exosomal Proteomics: Unveiling Novel Insights into Lung Cancer	44
EchoAGE: Echocardiography-based Neural Network Model Forecasting Heart Biological Age	42
Early Risk Prediction Model for Stroke-Heart Syndrome Following Endovascular Therapy	42
Unmet Medication Needs and the Association with Mortality in Older Adults: Equality-Oriented Monitoring toward Universal Health Coverage	41
VCAM-1 in Cognitive Impairment: Mechanisms, Biomarker Potential, and Therapeutic Targeting	41
Spinal Cord Injury and Ageing: The Role of Chronic Neuroinflammation	40
Citicoline for Supporting Memory in Aging Humans	39
Microcirculation Dysfunction in Subacute Stroke: The Role of Delayed Capillary Pericyte Loss	39
Role of Serotonylation and SERT Posttranslational Modifications in Alzheimer's Disease Pathogenesis	39
Normal Bone Matrix Mineralization but Altered Growth Plate Morphology in the LmnaG609G/G609G Mouse Model of Progeria	38
Age-, sex-, and ancestry-specific prevalence of hearing loss in UK Biobank and All of Us Research Program	38
Apolipoprotein CII: Cornerstone of Pathophysiological Interplay in Aortic Stenosis and type 2 Diabetes Mellitus	38
Emerging Roles of Ceramide in Cardiovascular Diseases	37
Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy	37
Endogenous Retroviruses Unveiled: A Comprehensive Review of Inflammatory Signaling/Senescence-Related Pathways and Therapeutic Strategies	36
Aβ Deposition in Extracellular Space Disrupts Glial-Neuron Communication and Triggers Alzheimer's Disease	35
Aging and “Age-Related” Diseases - What Is the Relation?	35
Stroke-Induced Retinal Dysfunction: Mechanisms, Diagnostics, and Future Directions	35
Decoding the Role of Familial Parkinson’s Disease-Related Genes in DNA Damage and Repair	35
Mitochondrial Dysfunction of Astrocytes Mediates Lipid Accumulation in Temporal Lobe Epilepsy	35
Autophagy in Disease Onset and Progression	34
Current Animal Model Systems for Ovarian Aging Research	34
Immunosenescence: Shaping the Hematological Narrative in the Era of Aging	34
Age-related Loss of miR-124 Causes Cognitive Deficits via Derepressing RyR3 Expression	34
Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity via AMPK/SOD2 Pathway	34
Elderly Dementia Needs Better Care in Post-COVID-19 Era	33
New Clues to Cardiovascular Disease: Erythrocyte Lifespan	32
Epigenetic Clocks Identify Harmful Epigenetic Aging Linked to Depression Severity and Cognitive Deficits in Major Depressive Disorder	31
(Dys)regulation of the Immune System in Parkinson’s Disease: Methodologies, Techniques, and Key Findings from Human Studies	31
Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging	30
Mortality Outcomes in a Large Population with and without Covert Cerebrovascular Disease	30
Applications of Chitosan and its Derivatives in the Treatment of Osteoarthritis	30
Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency	30
Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice	29
Semaphorins: Missing Signals in Age-dependent Alteration of Neuromuscular Junctions and Skeletal Muscle Regeneration	29
The Comorbidity of AD and PD: Exploring Clinical, Pathological, and Biomarker Interactions	29
Advancing Single-Cell Transcriptomic Analysis to Reveal Age-Related Skeletal Muscle Changes: A Systematic Review	29
Role of Microglia, Decreased Neurogenesis and Oligodendrocyte Depletion in Long COVID-Mediated Brain Impairments	29
NAD+ Metabolism and Mitochondrial Activity in the Aged Oocyte: Focus on the Effects of NAMPT Stimulation	29
Epidural Pulsation Accelerates the Drainage of Brain Interstitial Fluid	29
Intestinal Flora: A Potential New Regulator of Cardiovascular Disease	28
Clinical Potential of Immunotherapies in Subarachnoid Hemorrhage Treatment: Mechanistic Dissection of Innate and Adaptive Immune Responses	28
Revisiting Skeletal Muscle Dysfunction and Exercise in Chronic Obstructive Pulmonary Disease: Emerging Significance of Myokines	28
Different Aspects of Aging in Migraine	28
The Potential Role of Cytokines in Diabetic Intervertebral Disc Degeneration	28
Multimodal In Vivo Imaging Reveals BZBS Capsules Enhance Brain Function and Delay Aging in the Mouse Models	28

SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease	28
Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions	28
Emerging Roles of Adaptive Immune Response in Alzheimer's Disease	27
Minocycline Administration Does Not Have an Effect on Retinal Ganglion Cell Survival in a Murine Model of Ocular Hypertension	27
Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside	27
Biomarkers of Parkinson’s Disease: From Basic Research to Clinical Practice	27
Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential	27
Mechanistic Insights and Emerging Therapeutic Targets of Alzheimer's Disease: From the Perspective of Inter-Organ Crosstalk	27
Nuclear Protein Aggregates Disrupt RNA Processing and Alter Biomechanics in a Muscle Cell Model of OPMD	27
Histone Methylation, Energy Metabolism, and Alzheimer's Disease	27
Stem Cell-derived Exosomal MicroRNA as Therapy for Vascular Age-related Diseases	26
Stroke Exacerbates Respiratory Disorder and Cognition Impairment in Mice with Cerebral Amyloid Angiopathy	26
Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets	26
Acute Sarcopenia after Elective and Emergency Surgery	26
Irisin: A Potentially Fresh Insight into the Molecular Mechanisms Underlying Vascular Aging	25
Senescent T Cells in Age-Related Diseases	25
Potential of Neuroinflammation-Modulating Strategies in Tuberculous Meningitis: Targeting Microglia	25
DNA Methylation Modulates Aging Process in Adipocytes	25
Targeting Mitochondrial Sirtuins in Age-Related Neurodegenerative Diseases and Fibrosis	25
Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training	25
Intrinsic Capacity in Older Adults: Recent Advances	24
Role of Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review	24
Animal Models of Epilepsy: A Phenotype-oriented Review	24
Cerebral Glucose Metabolism and Potential Effects on Endoplasmic Reticulum Stress in Stroke	24
Hexokinase as a Central Hub in Neurodegeneration: From Metabolic Dysfunction to Therapeutic Innovation	24
Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice	23
Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43	23
The Emerging Role of the Mitochondrial Respiratory Chain in Skeletal Aging	23
Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects	22
The Metabolic Landscape in Osteoarthritis	22
Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency	22
Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases	22
A Standardized Protocol for Mouse Longevity Studies in Preclinical Drug Development	22
Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases	21
Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke	21
Investigating Causality and Shared Genetic Architecture between Neurodegenerative Disorders and Inflammatory Bowel Disease	21
Intestinal Permeability, Dysbiosis, Inflammation and Enteric Glia Cells: The Intestinal Etiology of Parkinson’s Disease	21
Conceptual Overview of Biological Age Estimation	20
Astrocyte-Derived Extracellular Vesicles for Ischemic Stroke: Therapeutic Potential and Prospective	20
Metformin Treatment Leads to Increased HIV Transcription and Gene Expression through Increased CREB Phosphorylation and Recruitment to the HIV LTR Promoter	20
Probiotic Limosilactobacillus Reuteri (Lactobacillus Reuteri) Extends the Lifespan of Drosophila Melanogaster through Insulin/IGF-1 Signaling	20
The Role of Liquid-Liquid Phase Separation in the Accumulation of Pathological Proteins: New Perspectives on the Mechanism of Neurodegenerative Diseases	19
Oligomeric β-Amyloid Suppresses Hippocampal γ-Oscillations through Activation of the mTOR/S6K1 Pathway	19
Bone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways	19
Identification of Cathepsin B as a Therapeutic Target for Ferroptosis of Macrophage after Spinal Cord Injury	19
Advancing Neurological Health: Insights into Aging, Immunity, and Vascular Dynamics	19
Brain Mitochondrial Dysfunction: A Possible Mechanism Links Early Life Anxiety to Alzheimer’s Disease in Later Life	19
	19
Association Between Dementia and Optical Coherence Tomography Scan Quality	18
The Greater Omentum: Multifaceted Interactions in Neurological Recovery and Disease Progression	18
Resveratrol: Harnessing Nature's Potential for Chronic Pain Relief	18
Shock Resuscitation - the Necessity and Priority of Renal Blood Perfusion Assessment	18
Establishing Predictors of Acute Sarcopenia: A Proof-Of-Concept Study Utilising Network Analysis	18
COVID-19 Pandemic and Osteoporosis in Elderly Patients	18
Aging Intensifies Myeloperoxidase Activity after Ischemic Stroke	18
CAG Repeat Expansions Increase N1-Methyladenine to Alter TDP-43 Phase Separation: Lights Up Therapeutic Intervention for Neurodegeneration	18
Alpha-Glucosidase Inhibitors in Aging and Aging-Related Diseases: Clinical Applications and Relevant Mechanisms	17
The Effects of Physical Running on Dendritic Spines and Amyloid-beta Pathology in 3xTg-AD Male Mice	17
Crossing Pathological Boundaries: Multi-Target Restoration of the Neurovascular Unit in Alzheimer's and Vascular Dementia—From Modern Therapeutics to Traditional Chinese Medicine	17
Mitochondria: A Potential Rejuvenation Tool against Aging	17
Are Older People Really More Susceptible to SARS-CoV-2?	16
Ovariectomy and High Fat-Sugar-Salt Diet Induced Alzheimer's Disease/Vascular Dementia Features in Mice	16
Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance	16
Brain Insulin Signaling is Associated with Late-Life Cognitive Decline	16
Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer’s Disease: A Systematic Review	16
Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application	16
Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications	16
Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents	15
Inhibiting Glutaminase Exerts Opposite Effects on Ovariectomy-Induced and Age-Related Reductions in Murine Bone Mass	15
Redefinition of Synovial Fibroblasts in Rheumatoid Arthritis	15
Deep Learning Based on Computed Tomography Predicts Response to Chemoimmunotherapy in Lung Squamous Cell Carcinoma	15
Aging Gut Microbiome in Healthy and Unhealthy Aging	15
Lars2 Deficiency-Induced Mitochondrial Dysfunction Drives the Emergence of a Pro-Inflammatory Stroke-Specific Microglial Subpopulation	15
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes	15
Interconnected Pathways of Alzheimer's Disease and Osteoporosis: A Review of Genetic, Hormonal, and Environmental Influences	15
Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer	15
Neuronal Senescence in the Aged Brain	15
Plasma GFAP and Amyloid Pathology Predict Cognitive Response to Multidomain Interventions in MCI	14
Osteoporosis in Relation to a Bone-Related Aging Biomarker Derived from the Urinary Proteomic Profile: A Population Study	14
Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians	14

A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?	14
Cardiovascular Health, as per Life's Essential 8, and Impaired Lower-Extremity Function in Older Adults	14
Hypoxic Preconditioning Mitigates Acute Hypoxia Induced MS/VDB Cholinergic Cell Loss and Memory Impairments	14
Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease	14
Atherosclerosis: The Involvement of Immunity, Cytokines and Cells in Pathogenesis, and Potential Novel Therapeutics	14
Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation	14
Microglial Histaminergic Signaling Promotes Interleukin-10 Production and Ameliorates Motor Dysfunction in Parkinson's Disease	14
Neurofilament-Light Chain and Glial Fibrillary Acidic Protein as Blood-Based Delirium Risk Markers: A Multicohort Study	14
Mechanisms and Pathogenesis of Diabetic Cognitive Impairment: A Comprehensive Review	14
Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and Modulators	13
Revolutionizing Senescence Detection: Advancements from Traditional Methods to Cutting-Edge Techniques	13
Melatonin as an Antioxidant Agent in Stroke: An Updated Review	13
cGAS-STING Pathway Performance in the Vulnerable Atherosclerotic Plaque	13
Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations	13
Lamotrigine Restores Impairments in Theta Rhythms and LTP as Early Biomarkers of Aβ1-42-Induced Hippocampal Network Dysfunction	13
Changes in Plasma Neutral and Ether-Linked Lipids Are Associated with The Pathology and Progression of Alzheimer’s Disease	13
Age-Related Hormones Changes and Its Impact on Health Status and Lifespan	13
Responsiveness to Tocilizumab in Anti-Acetylcholine Receptor-Positive Generalized Myasthenia Gravis	13
Epigenetic Regulation of Regulated Cell Death in Aging-Related Diseases: Clinical Perspectives	13
Role and Mechanism of Epigenetic Regulation in the Aging of Germ Cells: Prospects for Targeted Interventions	12
Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments	12
Circadian Rhythm and the Risk of Cardiovascular Diseases: Genetic Evidence	12
Traveling Subject-Informed Harmonization Increases Reliability of Brain Diffusion Tensor and Neurite Mapping	12
Crosstalk between Circadian Rhythm Dysregulation and Tumorigenesis, Tumor Metabolism and Tumor Immune Response	12
Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice	12
Profile for Brain Disease Research Infrastructure for Data Gathering and Exploration (BRIDGE) Platform	12
Irreversibility of Pulmonary Fibrosis	12
Sarcopenic Obesity: An Emerging Public Health Problem, But an Answer Appears to Be Available	12
nillin Recedes in p53-Dependent Senescence of Tumor Cells and Reappears in Cells Escaping from Senescence	11
Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses	11
Optimal Evaluation and Treatment of Cardiac Rehabilitation for Patients Following TAVR: A Personalized Program Based on The Five Prescriptions	11
Differential Effects of Endurance Exercise on Musculoskeletal and Hematopoietic Modulation in Old Mice	11
Clinical Characteristics, Transmissibility, Pathogenicity, Susceptible Populations, and Re-infectivity of Prominent COVID-19 Variants	11
A longitudinal Analysis of the Association between Socioeconomic Position and Multimorbidity in the European Prospective Investigation into Cancer and Nutrition Study	11
The Role of Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis	11
Neuroserpin and Extracellular Vesicles in Ischemic Stroke: Partners in Neuroprotection?	11
Unveiling the Relation between Cellular Ageing, Epigenetics and Cancer	11
Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases	11
USP7 Inhibits Osteoclastogenesis via Dual Effects of Attenuating TRAF6/TAK1 Axis and Stimulating STING Signaling	11
Age and Sex Affect Essential Tremor (ET) Plus: Clinical Heterogeneity in ET Based on the National Survey in China	11
Vascular Calcification in Chronic Kidney Disease: An Update and Perspective	11
Bidirectional Crosstalk between the Heart and Brain in Alzheimer's Disease	11
Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies	11
YAP/TAZ as Molecular Targets in Skeletal Muscle Atrophy and Osteoporosis	11
Genetic Risk, Inflammation, and Therapeutics: An Editorial Overview of Recent Advances in Aging Brains and Neurodegeneration	11
A Framework for an Effective Healthy Longevity Clinic	10
Toward the Identification of Neurophysiological Biomarkers for Alzheimer’s Disease in Down Syndrome: A Potential Role for Cross-Frequency Phase-Amplitude Coupling Analysis	10
Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease	10
Mesenchymal Stem Cell-Derived Exosomes Promote Recovery of The Facial Nerve Injury through Regulating Macrophage M1 and M2 Polarization by Targeting the P38 MAPK/NF-Κb Pathway	10
Diagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis	10
SARS-CoV-2 S Protein Reduces Cytoprotective Defenses and Promotes Human Endothelial Cell Senescence	10
COVID-19 and Cardiovascular Diseases: From Cellular Mechanisms to Clinical Manifestations	10
Will New Variants Emerge after Delta and Omicron?	10
Underlying Mechanisms and Treatment of Cellular Senescence-Induced Biological Barrier Interruption and Related Diseases	10
NeuroD1 Regulated Endothelial Gene Expression to Modulate Transduction of AAV-PHP.eB and Recovery Progress after Ischemic Stroke	10
Mitochondrial Transfer in the Neurovascular Unit, Not Only for Energy Rescue: A Systematic Review	10
Gut Virome and Aging: Phage-Driven Microbial Stability and Immune Modulation	10
Recent Advances in Aging-Related Diseases: Accelerated Aging, Molecular Mechanisms, Interventions, and Therapies	10
Metabolic Dysfunction in Idiopathic Intracranial Hypertension: Current Theories and Updates	10
Histone Deacetylase 3: A Potential Therapeutic Target for Atherosclerosis	10
Predictive Value of Plasma Neurofilament Light Chain for Neurological Outcomes in Patients with Intracerebral Hemorrhage	10
HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes	10