Aging and Disease

Article	Citations
Burn Injuries Accelerate Biological Aging and Increase the Epigenetically Inferred Risk of Mortality and Frailty	108
Revisiting the Role of Mitochondrial DNA Mutations in Aging: Bridging Theoretical Expectations with Empirical Observations	107
Metabolic Dysregulation in Parkinson’s Disease: Non-Oxidative Phosphorylation and Its Role in Brain Energy Metabolism	103
Aligning Intrinsic Capacity and Geroscience: Linking Function with Biology	79
Correlations between Aging, Telomeres, and Natural Compounds	78
Vascular Contributions to Healthy Aging and Dementia	72
The HLA-B*57:01 Haplotype, Genetic Key Linking Innate Immunity and Longevity	68
The Roles of T cells in Immune Checkpoint Inhibitor-Induced Arthritis	64
Neuropsychological Profiles in Genetic Frontotemporal Dementia: A Meta-Analysis and Systematic Review	59
Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies	57
Axonal Energy Crisis and Calcium Phosphate Dysregulation as Pathogenesis of Optic Disc Drusen	55
The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung	53
Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies	52
Quantum Sensing for Precision Organ Aging Assessment	52
Cross-Tissue Proteomic Mendelian Randomization Identifies Therapeutic Targets for Vascular Dementia	50
Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine	48
Lysine Malonylation and Its Links to Metabolism and Diseases	48
Neuronal Intranuclear Inclusion Disease with NOTCH2NLC GGC Repeat Expansion: A Systematic Review and Challenges of Phenotypic Characterization	47
KRT5+/p63+ Stem Cells Undergo Senescence in the Human Lung with Pathological Aging	45
Retinal Pigment Epithelium Phagocytosis and Retinal Degenerative Diseases	45
Updates in Intravenous Thrombolysis Treatment for Acute Ischemic Stroke in Asian Populations	45
Vascular Aging and Atherosclerosis: A Perspective on Aging	45
Exploiting the Fractionation of Stable Isotopes in Biochemical Processes for Medical Diagnosis: A Narrative Review	44
A Systematic Review of Intervention Trials Utilizing Biomarkers Among Informal Caregivers of People with Alzheimer's Disease & Related Dementias	44
Role of AMPK and Sirtuins in Aging Heart: Basic and Translational Aspects	43

Neuroinflammation as a Link in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis	43
Early Risk Prediction Model for Stroke-Heart Syndrome Following Endovascular Therapy	43
Normal Bone Matrix Mineralization but Altered Growth Plate Morphology in the LmnaG609G/G609G Mouse Model of Progeria	41
Unmet Medication Needs and the Association with Mortality in Older Adults: Equality-Oriented Monitoring toward Universal Health Coverage	41
Age-, sex-, and ancestry-specific prevalence of hearing loss in UK Biobank and All of Us Research Program	40
Apolipoprotein CII: Cornerstone of Pathophysiological Interplay in Aortic Stenosis and type 2 Diabetes Mellitus	40
VCAM-1 in Cognitive Impairment: Mechanisms, Biomarker Potential, and Therapeutic Targeting	39
Aβ Deposition in Extracellular Space Disrupts Glial-Neuron Communication and Triggers Alzheimer's Disease	39
Stroke-Induced Retinal Dysfunction: Mechanisms, Diagnostics, and Future Directions	37
Immunosenescence: Shaping the Hematological Narrative in the Era of Aging	36
Telomeres: Dysfunction, Maintenance, Aging and Cancer	36
Beyond Amyloid: Rethinking the Foundations of Alzheimer’s Disease Pathogenesis and Therapy	36
Autophagy in Disease Onset and Progression	35
Role of Serotonylation and SERT Posttranslational Modifications in Alzheimer's Disease Pathogenesis	35
Exosomal Proteomics: Unveiling Novel Insights into Lung Cancer	34
EchoAGE: Echocardiography-based Neural Network Model Forecasting Heart Biological Age	34
Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy	34
Dopamine-Induced L-Lactate Production in Cortical Astrocytes Cross-Reacts with β1-Adrenoceptor-Mediated cAMP Signalling	33
Spinal Cord Injury and Ageing: The Role of Chronic Neuroinflammation	33
Microcirculation Dysfunction in Subacute Stroke: The Role of Delayed Capillary Pericyte Loss	33
Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity via AMPK/SOD2 Pathway	32
Mitochondrial Dysfunction of Astrocytes Mediates Lipid Accumulation in Temporal Lobe Epilepsy	32
Aging and “Age-Related” Diseases - What Is the Relation?	32
Endogenous Retroviruses Unveiled: A Comprehensive Review of Inflammatory Signaling/Senescence-Related Pathways and Therapeutic Strategies	31
New Clues to Cardiovascular Disease: Erythrocyte Lifespan	30
Epigenetic Clocks Identify Harmful Epigenetic Aging Linked to Depression Severity and Cognitive Deficits in Major Depressive Disorder	30
Advancing Single-Cell Transcriptomic Analysis to Reveal Age-Related Skeletal Muscle Changes: A Systematic Review	28
Multimodal In Vivo Imaging Reveals BZBS Capsules Enhance Brain Function and Delay Aging in the Mouse Models	28
Clinical Potential of Immunotherapies in Subarachnoid Hemorrhage Treatment: Mechanistic Dissection of Innate and Adaptive Immune Responses	28
(Dys)regulation of the Immune System in Parkinson’s Disease: Methodologies, Techniques, and Key Findings from Human Studies	28
The Comorbidity of AD and PD: Exploring Clinical, Pathological, and Biomarker Interactions	27
Single Cell RNAseq Analysis of Thyroid Hormone Effects on Retinal Glial Cells	27
Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice	27
Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency	27
Histone Methylation, Energy Metabolism, and Alzheimer's Disease	26
Elderly Dementia Needs Better Care in Post-COVID-19 Era	26
Revisiting Skeletal Muscle Dysfunction and Exercise in Chronic Obstructive Pulmonary Disease: Emerging Significance of Myokines	26
Semaphorins: Missing Signals in Age-dependent Alteration of Neuromuscular Junctions and Skeletal Muscle Regeneration	26
Applications of Chitosan and its Derivatives in the Treatment of Osteoarthritis	24
Mortality Outcomes in a Large Population with and without Covert Cerebrovascular Disease	24
Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging	24
Visual Dependence in Postural Control Is Increased in Older Adults	24
Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential	23
Epidural Pulsation Accelerates the Drainage of Brain Interstitial Fluid	23
Role of Microglia, Decreased Neurogenesis and Oligodendrocyte Depletion in Long COVID-Mediated Brain Impairments	22
Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions	22
Different Aspects of Aging in Migraine	22
NAD+ Metabolism and Mitochondrial Activity in the Aged Oocyte: Focus on the Effects of NAMPT Stimulation	22
Minocycline Administration Does Not Have an Effect on Retinal Ganglion Cell Survival in a Murine Model of Ocular Hypertension	21
SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease	21

Mechanistic Insights and Emerging Therapeutic Targets of Alzheimer's Disease: From the Perspective of Inter-Organ Crosstalk	20
Nuclear Protein Aggregates Disrupt RNA Processing and Alter Biomechanics in a Muscle Cell Model of OPMD	20
Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside	20
Biomarkers of Parkinson’s Disease: From Basic Research to Clinical Practice	19
Stroke Exacerbates Respiratory Disorder and Cognition Impairment in Mice with Cerebral Amyloid Angiopathy	19
Irisin: A Potentially Fresh Insight into the Molecular Mechanisms Underlying Vascular Aging	19
Potential of Neuroinflammation-Modulating Strategies in Tuberculous Meningitis: Targeting Microglia	19
A Signature of Senescence Based on An Analysis of Selected Markers in Primary Vascular Smooth Muscle Cells Cultured In Vitro and Derived from Atherosclerotic Plaque	19
Expanding on Gut Microbiota Insights in Sarcopenia and Osteoporosis	18
Targeting Mitochondrial Sirtuins in Age-Related Neurodegenerative Diseases and Fibrosis	18
Emerging Roles of Adaptive Immune Response in Alzheimer's Disease	18
Hexokinase as a Central Hub in Neurodegeneration: From Metabolic Dysfunction to Therapeutic Innovation	18
Health Related Quality of Life in Adults with 13 Chronic Diseases before Age 65 and after Age 65 Using Fuzzy Rough Analysis of SF-36 Domains	18
Senescent T Cells in Age-Related Diseases	18
The Emerging Role of the Mitochondrial Respiratory Chain in Skeletal Aging	17
A Standardized Protocol for Mouse Longevity Studies in Preclinical Drug Development	17
Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training	17
Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke	17
Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects	17
The Lung-Brain Axis in Cognitive Impairment and Dementia: Mechanisms and Therapeutic Prospects	17
The Interplay Between Physical Exercise, Nutritional Strategies, and Brain-Derived Neurotrophic Factor in Promoting Cognitive Performance	17
Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency	17
Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice	17
Metformin Treatment Leads to Increased HIV Transcription and Gene Expression through Increased CREB Phosphorylation and Recruitment to the HIV LTR Promoter	16
Astrocyte-Derived Extracellular Vesicles for Ischemic Stroke: Therapeutic Potential and Prospective	16
Oligomeric β-Amyloid Suppresses Hippocampal γ-Oscillations through Activation of the mTOR/S6K1 Pathway	16
Conceptual Overview of Biological Age Estimation	16
Probiotic Limosilactobacillus Reuteri (Lactobacillus Reuteri) Extends the Lifespan of Drosophila Melanogaster through Insulin/IGF-1 Signaling	16
Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43	16
The Role of Liquid-Liquid Phase Separation in the Accumulation of Pathological Proteins: New Perspectives on the Mechanism of Neurodegenerative Diseases	16
Identification of Cathepsin B as a Therapeutic Target for Ferroptosis of Macrophage after Spinal Cord Injury	16
Establishing Predictors of Acute Sarcopenia: A Proof-Of-Concept Study Utilising Network Analysis	15
Perspectives on Pathological Crosstalk between Malocclusion and Multi-organ Systems: The Hidden Face of an Iceberg	15
CAG Repeat Expansions Increase N1-Methyladenine to Alter TDP-43 Phase Separation: Lights Up Therapeutic Intervention for Neurodegeneration	15
Engineering the Future of Longevity R&D: The Case for AI-Driven, Integrated Biotechnology Ecosystems	15
Advancing Neurological Health: Insights into Aging, Immunity, and Vascular Dynamics	15
Crossing Pathological Boundaries: Multi-Target Restoration of the Neurovascular Unit in Alzheimer's and Vascular Dementia—From Modern Therapeutics to Traditional Chinese Medicine	14
Aging Intensifies Myeloperoxidase Activity after Ischemic Stroke	14
Brain Insulin Signaling is Associated with Late-Life Cognitive Decline	14
Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application	14
Association Between Dementia and Optical Coherence Tomography Scan Quality	14
Bone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways	14
The Greater Omentum: Multifaceted Interactions in Neurological Recovery and Disease Progression	13
Prolonged Mild Sleep Restriction Changes Epigenome-Wide DNA Methylation in Peripheral Blood Cells: A Randomized Crossover Trial	13
Resveratrol: Harnessing Nature's Potential for Chronic Pain Relief	13
Mitochondria: A Potential Rejuvenation Tool against Aging	13
Ovariectomy and High Fat-Sugar-Salt Diet Induced Alzheimer's Disease/Vascular Dementia Features in Mice	13
Alpha-Glucosidase Inhibitors in Aging and Aging-Related Diseases: Clinical Applications and Relevant Mechanisms	13
Redefinition of Synovial Fibroblasts in Rheumatoid Arthritis	13
Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer’s Disease: A Systematic Review	13
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes	13
Neuronal Senescence in the Aged Brain	12
Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer	12
Cardiovascular Health, as per Life's Essential 8, and Impaired Lower-Extremity Function in Older Adults	12
Spinal cord changes in Neurodegenerative and Neuroinflammatory Diseases	12
Lars2 Deficiency-Induced Mitochondrial Dysfunction Drives the Emergence of a Pro-Inflammatory Stroke-Specific Microglial Subpopulation	12
Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance	12
Inhibiting Glutaminase Exerts Opposite Effects on Ovariectomy-Induced and Age-Related Reductions in Murine Bone Mass	12
Interconnected Pathways of Alzheimer's Disease and Osteoporosis: A Review of Genetic, Hormonal, and Environmental Influences	12
Responsiveness to Tocilizumab in Anti-Acetylcholine Receptor-Positive Generalized Myasthenia Gravis	12
Microglial Histaminergic Signaling Promotes Interleukin-10 Production and Ameliorates Motor Dysfunction in Parkinson's Disease	12
Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications	12
Plasma GFAP and Amyloid Pathology Predict Cognitive Response to Multidomain Interventions in MCI	12
Hypoxic Preconditioning Mitigates Acute Hypoxia Induced MS/VDB Cholinergic Cell Loss and Memory Impairments	12
Osteoporosis in Relation to a Bone-Related Aging Biomarker Derived from the Urinary Proteomic Profile: A Population Study	12
Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians	12
Lamotrigine Restores Impairments in Theta Rhythms and LTP as Early Biomarkers of Aβ1-42-Induced Hippocampal Network Dysfunction	11
Biological Age Should Anchor Age-Related Disease Research	11
Neurofilament-Light Chain and Glial Fibrillary Acidic Protein as Blood-Based Delirium Risk Markers: A Multicohort Study	11
Mechanisms and Pathogenesis of Diabetic Cognitive Impairment: A Comprehensive Review	11
Male Monocyte-Like Cells are Prone to a Senescence-Induced Pro-inflammatory State	11
Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice	11
Deep Learning Based on Computed Tomography Predicts Response to Chemoimmunotherapy in Lung Squamous Cell Carcinoma	11
Critical Considerations for Mesenchymal Stem Cell-based Therapies in Osteoarthritis and Spinal Cord Injury: A Narrative Review	11
Interthalamic Adhesion as a Potential Structural Regulator of Cerebrospinal Fluid Dynamics in the Third Ventricle	11
Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease	11
Epigenetic Regulation of Regulated Cell Death in Aging-Related Diseases: Clinical Perspectives	11
A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?	10
Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and Modulators	10
Changes in Plasma Neutral and Ether-Linked Lipids Are Associated with The Pathology and Progression of Alzheimer’s Disease	10

The Role of Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis	10
Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations	10
Aging Gut Microbiome in Healthy and Unhealthy Aging	10
Neuroserpin and Extracellular Vesicles in Ischemic Stroke: Partners in Neuroprotection?	10
Revolutionizing Senescence Detection: Advancements from Traditional Methods to Cutting-Edge Techniques	10
Age-Related Hormones Changes and Its Impact on Health Status and Lifespan	10
Crosstalk between Circadian Rhythm Dysregulation and Tumorigenesis, Tumor Metabolism and Tumor Immune Response	10
Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases	10
Sex- and Age-Dependent Metabolic and Inflammatory Pathways in Cardiomyopathy: The Role of Sirtuins, Inflammaging and Mitochondrial Homeostasis	10
Role and Mechanism of Epigenetic Regulation in the Aging of Germ Cells: Prospects for Targeted Interventions	9
The α-MSH-MC1R Axis Modulates Sex-Specific Senescence and Inflammation Processes in Human Articular Chondrocytes and Mice Knee Joints	9
Optimal Evaluation and Treatment of Cardiac Rehabilitation for Patients Following TAVR: A Personalized Program Based on The Five Prescriptions	9
Circadian Rhythm and the Risk of Cardiovascular Diseases: Genetic Evidence	9
Bidirectional Crosstalk between the Heart and Brain in Alzheimer's Disease	9
Unveiling the Relation between Cellular Ageing, Epigenetics and Cancer	9
Comprehensive Review of Therapeutic Efficacy and Underlying Mechanisms of Various Exercise Modalities in Treating Osteoporosis	9
A longitudinal Analysis of the Association between Socioeconomic Position and Multimorbidity in the European Prospective Investigation into Cancer and Nutrition Study	9
Underlying Mechanisms and Treatment of Cellular Senescence-Induced Biological Barrier Interruption and Related Diseases	9
Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses	9
Mesenchymal Stem Cell-Derived Exosomes Promote Recovery of The Facial Nerve Injury through Regulating Macrophage M1 and M2 Polarization by Targeting the P38 MAPK/NF-Κb Pathway	9
nillin Recedes in p53-Dependent Senescence of Tumor Cells and Reappears in Cells Escaping from Senescence	9
Traveling Subject-Informed Harmonization Increases Reliability of Brain Diffusion Tensor and Neurite Mapping	8
Differential Effects of Endurance Exercise on Musculoskeletal and Hematopoietic Modulation in Old Mice	8
Profile for Brain Disease Research Infrastructure for Data Gathering and Exploration (BRIDGE) Platform	8
Vascular Aging and Multi-Omic Regulation in Ischemic Stroke: Toward Precision Neurorepair	8
Islet Inflammation and Endocrine Function in Aging - Evaluating the Role of Toll-like receptor 4	8
NeuroD1 Regulated Endothelial Gene Expression to Modulate Transduction of AAV-PHP.eB and Recovery Progress after Ischemic Stroke	8
Metabolic Dysfunction in Idiopathic Intracranial Hypertension: Current Theories and Updates	8
YAP/TAZ as Molecular Targets in Skeletal Muscle Atrophy and Osteoporosis	8
Emerging Roles of Skeletal Muscle-Derived Exosomal miRNAs in Metabolic Regulation: A Perspective	8
Metabolic-Inflammatory Syndrome: Decoding the Metabolic-Immune Axis for Precision Intervention	8
Risk Factors for Oropharyngeal Dysphagia in Older Adults - Evidence from Consorci Sanitari Del Maresme and Mataró University Hospital, Catalonia, Spain	8
Genetic Risk, Inflammation, and Therapeutics: An Editorial Overview of Recent Advances in Aging Brains and Neurodegeneration	8
USP7 Inhibits Osteoclastogenesis via Dual Effects of Attenuating TRAF6/TAK1 Axis and Stimulating STING Signaling	8
Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies	8
Mitochondrial Transfer in the Neurovascular Unit, Not Only for Energy Rescue: A Systematic Review	8
CD16-CD56bright NK Cells: A Protective NK Cell Subset for Progression and Prognosis in Amyotrophic Lateral Sclerosis	8
Diagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis	8
Overexpression of RACGAP1 by E2F1 Promotes Neuroendocrine Differentiation of Prostate Cancer by Stabilizing EZH2 Expression	7
Senescence in Aging and Alzheimer’s Disease	7
Decoding Microglial Polarization and Metabolic Reprogramming in Neurodegenerative Diseases: Implications for Disease Progression and Therapy	7
Scientific Advancements in Drug Development and Trials for Urothelial Carcinoma: Insights From the 2023 ASCO-GU Cancers Symposium	7
Gut Virome and Aging: Phage-Driven Microbial Stability and Immune Modulation	7
Biological Aging in Combination with Lifestyle Factors in the Blood-Based Methylome: A Biomarker for Colorectal Cancer Susceptibility in African American Women	7
From Insight to Eyesight: Unveiling the Secrets of the Insulin-Like Growth Factor Axis in Retinal Health	7
Chondroitin Sulfate Proteoglycans Revisited: Its Mechanism of Generation and Action for Spinal Cord Injury	7
ARID1a Gene as a Potential Early Marker to Tackle Endometriosis-Associated Ovarian Cancer	7
Endothelial Senescence in Neurological Diseases	7
Impairment of Tricarboxylic Acid Cycle (TCA) Cycle in Alzheimer's Disease: Mechanisms, Implications, and Potential Therapies	7
Hallmarks of Skin Aging: Update	7
A Framework for an Effective Healthy Longevity Clinic	7
The Neglected Sibling: NLRP2 Inflammasome in the Nervous System	7
Aging Deteriorates Blood Brain Barrier Function and Polarizes Adaptive T Cell Expansion Contributing to Neurocognitive Damage in Experimental Cirrhosis	7
SARS-CoV-2 S Protein Reduces Cytoprotective Defenses and Promotes Human Endothelial Cell Senescence	7
HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes	7
ROS-Induced Endothelial Dysfunction in the Pathogenesis of Atherosclerosis	7
Predictive Value of Plasma Neurofilament Light Chain for Neurological Outcomes in Patients with Intracerebral Hemorrhage	7
The Microglial Lactate-Lactylation Axis as a Metabolic-Epigenetic Driver of Alzheimer’s Disease	7
COVID-19 and Cardiovascular Diseases: From Cellular Mechanisms to Clinical Manifestations	7
Hypoxic Conditioning: A Potential Perioperative Strategy to Reduce Abdominal Aortic Occlusion-Related Injury in Mouse Proximal and Distal Organs	7
Recent Advances in Aging-Related Diseases: Accelerated Aging, Molecular Mechanisms, Interventions, and Therapies	7