Aging and Disease

Article	Citations
Effect of COVID-19 on Geriatric Medical Services in China	223
Juvenile Plasma Factors Improve Organ Function and Survival following Injury by Promoting Antioxidant Response	105
Protein Synthesis Errors and Longevity: A Lesson from a Single Amino Acid Mutation Study	99
Pip5k1c Loss in Chondrocytes Causes Spontaneous Osteoarthritic Lesions in Aged Mice	71
KRT5+/p63+ Stem Cells Undergo Senescence in the Human Lung with Pathological Aging	68
Broadening Horizons: Exploring mtDAMPs as a Mechanism and Potential Intervention Target in Cardiovascular Diseases	66
Vascular Aging and Atherosclerosis: A Perspective on Aging	61
Scoping Review of Technological Solutions for Community Dwelling Older Adults and Implications for Instrumental Activities of Daily Living	57
Neuronal Intranuclear Inclusion Disease with NOTCH2NLC GGC Repeat Expansion: A Systematic Review and Challenges of Phenotypic Characterization	56
Advancing Hydrocephalus Management: Pathogenesis Insights, Therapeutic Innovations, and Emerging Challenges	54
Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells	51
Atherosclerosis: The Involvement of Immunity, Cytokines and Cells in Pathogenesis, and Potential Novel Therapeutics	50
A Connection Between the Gut Microbiome and Epigenetic Modification in Age-Related Cancer: A Narrative Review	50
Current Understanding of Marginal Grafts in Liver Transplantation	43
Cellular Senescence in the Regenerative Niche Hampers Skeletal Muscle Repair	42
Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice	41
Atrial Fibrillation Underlies Cardiomyocyte Senescence and Contributes to Deleterious Atrial Remodeling during Disease Progression	41
Neuron-targeted Knockout of APE1 Forces Premature Cognitive Impairment and Synaptic Dysfunction in Adult Mice	41
The Role of Myeloid-Derived Suppressor Cells in Multiple Sclerosis and Its Animal Model	41
Higher Functional Connectivity of Ventral Attention and Visual Network to Maintain Cognitive Performance in White Matter Hyperintensity	39
Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?	39
Aging Gut Microbiome in Healthy and Unhealthy Aging	38
Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies	38
Revisiting the Role of Mitochondrial DNA Mutations in Aging: Bridging Theoretical Expectations with Empirical Observations	37
Exploiting the Fractionation of Stable Isotopes in Biochemical Processes for Medical Diagnosis: A Narrative Review	37

Inflammatory Markers Associated with Physical Frailty and Cognitive Impairment	37
Unveiling the Therapeutic Promise of Epigenetics in Vascular Cognitive Impairment and Vascular Dementia	35
Upregulation of Na/H Exchanger in Astrogliosis and Early Alzheimer’s Disease Pathogenesis	34
A Population-Based Scoring System to Assess the Impact of Individual Risk Factors on Vascular Health	31
Erratum to “NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice	31
Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer	30
Molecular Regulation Mechanism of Microglial Autophagy in the Pathology of Alzheimer's Disease	28
Aging Impairs the Cellular Interplay between Myeloid Cells and Mesenchymal Cells during Skin Healing in Mice	28
Immunological Landscape of Retinal Ischemia-Reperfusion Injury: Insights into Resident and Peripheral Immune Cell Responses	27
Association of Plasma Markers of Alzheimer’s Disease, Neurodegeneration, and Neuroinflammation with the Choroid Plexus Integrity in Aging	27
Revolutionizing Senescence Detection: Advancements from Traditional Methods to Cutting-Edge Techniques	27
Stress Hormones: Unveiling the Role in Accelerated Cellular Senescence	26
Neuronal Zinc Transporter ZnT3 Modulates Cerebral Ischemia-Induced Blood-Brain Barrier Disruption	25
Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine	25
Age-Related Changes in the Glycolytic Enzymes of M2-Isoform of Pyruvate Kinase and Fructose-1,6-Bisphosphate Aldolase: Implications to Age-Related Macular Degeneration	24
Bile Acids in Cardiovascular Diseases: Don’t Forget Hyocholic Acid	24
A Reliable Nonhuman Primate Model of Ischemic Stroke with Reproducible Infarct Size and Long-term Sensorimotor Deficits	24
cGAS-STING Pathway Performance in the Vulnerable Atherosclerotic Plaque	24
Sub-Retinal Injection of Human Lipofuscin in the Mouse - A Model of “Dry” Age-Related Macular Degeneration?	23
Inflammatory Bridges: Interconnections Between Alzheimer’s Disease and Bone Health	23
Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update	23
Sarcopenia and Cognitive Decline in Hospitalized Older Adults from a Prospective Study	23
Cellular Components of the Blood-Brain Barrier and Their Involvement in Aging-Associated Cognitive Impairment	23
Expert Consensus on Prevention and Treatment of Aging-Related Gonadal Dysfunction	22
Progressive Disruption of Sphingosine-1-Phosphate Receptor 1 Correlates with Blood-Brain Barrier Leakage in A Rat Model of Chronic Hypoxic Hypoperfusion	22
Fighting with Aging: The Secret for Keeping Health and Longevity of Naked Mole Rats	22
Deep Learning Based on Computed Tomography Predicts Response to Chemoimmunotherapy in Lung Squamous Cell Carcinoma	22
Effects of Hypoxia on Cerebral Microvascular Angiogenesis: Benefits or Damages?	22
A Comprehensive Prediction Model for Futile Recanalization in AIS Patients Post-Endovascular Therapy: Integrating Clinical, Imaging, and No-Reflow Biomarkers	22
The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung	21
Polypharmacological Potential of Phosphodiesterase 5 Inhibitors for the Treatment of Neurocognitive Disorders	21
Is the β Common Receptor the Key Molecule for the Protective Effect of Erythropoietin?	21
Mitigating COVID-19 Mortality and Morbidity in China's Aging Population: A Focus on Available Medications and Future Developments	21
Neuron Derived Cold-Inducible RNA-Binding Protein Promotes NETs Formation to Exacerbate Brain Endothelial Barrier Disruption after Ischemic Stroke	20
Literacy for Frailty among Undergraduate Medical Education: An Under-Recognized Opportunity to Improve Geriatric Care	20
Association of Inflammatory Mediators with Mitochondrial DNA Variants in Geriatric COVID-19 Patients	20
Pannexin1 Channel-Mediated Inflammation in Acute Ischemic Stroke	20
Axonal Energy Crisis and Calcium Phosphate Dysregulation as Pathogenesis of Optic Disc Drusen	19
Neuropsychological Profiles in Genetic Frontotemporal Dementia: A Meta-Analysis and Systematic Review	19
Senescent Astrocytes Derived from Human Pluripotent Stem Cells Reveal Age-Related Changes and Implications for Neurodegeneration	18
Tumor Immune Microenvironment and Immunotherapy in Non-Small Cell Lung Cancer: Update and New Challenges	18
Crosstalk between Circadian Rhythm Dysregulation and Tumorigenesis, Tumor Metabolism and Tumor Immune Response	18
Vascular Contributions to Healthy Aging and Dementia	18
Effect of SARS CoV2-Neutralizing Monoclonal Antibody on Hospitalization and Mortality in Long-Term Care Facility Residents	18
Addressing Healthy Aging: Time to Stop a Tsunami of Rising Alzheimer’s Disease	17
The Role of the Complement System in Synaptic Pruning after Stroke	17
Oxidative Stress Promotes Axonal Atrophy through Alterations in Microtubules and EB1 Function	17
The Role of Hypoxia in Longevity	17
EP3 Receptor Deficiency Improves Vascular Remodeling and Cognitive Impairment in Cerebral Small Vessel Disease	17
The Roles of T cells in Immune Checkpoint Inhibitor-Induced Arthritis	17

Microbiota-Gut-Brain Axis Dysregulation in Alzheimer's Disease: Multi-Pathway Effects and Therapeutic Potential	17
Osteoporosis in Relation to a Bone-Related Aging Biomarker Derived from the Urinary Proteomic Profile: A Population Study	17
Emerging Links between Cerebral Blood Flow Regulation and Cognitive Decline: A Role for Brain Microvascular Pericytes	16
Plasma Neurofilament Light Chain Predicts Mortality and Long-Term Neurological Outcomes in Patients with Intracerebral Hemorrhage	16
Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation	16
Responsiveness to Tocilizumab in Anti-Acetylcholine Receptor-Positive Generalized Myasthenia Gravis	16
A Potential Target for Clinical Atherosclerosis: A Novel Insight Derived from TPM2	16
Changes in Plasma Neutral and Ether-Linked Lipids Are Associated with The Pathology and Progression of Alzheimer’s Disease	16
Physical Exercise Counteracts Aging-Associated White Matter Demyelination Causing Cognitive Decline	15
Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies	15
Early Aβ42 Exposure Causes Learning Impairment in Later Life	15
Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations	15
Association between Dysbiosis in the Gut Microbiota of Primary Osteoporosis Patients and Bone Loss	15
Prospective Longitudinal Perfusion in Probable Alzheimer’s Disease Correlated with Atrophy in Temporal Lobe	15
The Emerging Role of Interleukin-(IL)-11/IL-11R in Bone Metabolism and Homeostasis: From Cytokine to Osteokine	15
Inhibiting Glutaminase Exerts Opposite Effects on Ovariectomy-Induced and Age-Related Reductions in Murine Bone Mass	14
Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments	14
Aquaporin-4 and Cognitive Disorders	14
Irreversibility of Pulmonary Fibrosis	14
Bridging the Gap: Investigating the Link between Inflammasomes and Postoperative Cognitive Dysfunction	14
Neuroinflammaging: A Tight Line Between Normal Aging and Age-Related Neurodegenerative Disorders	14
Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease	14
Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians	14
Decoding the Multiple Identities and Crosstalk of Organokines in Obesity-Related Type 2 Diabetes Mellitus	14
Gene Therapy Strategies Targeting Aging-Related Diseases	14
Effects of Resistance Exercise on Neuroprotective Factors in Middle and Late Life: A Systematic Review and Meta-Analysis	13
Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal	13
Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and Modulators	13
Lysine Malonylation and Its Links to Metabolism and Diseases	13
Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging	13
A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?	13
Which Factors Influence Healthy Aging? A Lesson from the Longevity Village of Bama in China	13
Melatonin as an Antioxidant Agent in Stroke: An Updated Review	13
Interconnected Pathways of Alzheimer's Disease and Osteoporosis: A Review of Genetic, Hormonal, and Environmental Influences	13
Long RNA Profiles of Human Brain Extracellular Vesicles Provide New Insights into the Pathogenesis of Alzheimer’s Disease	13
POSTN Secretion by Extracellular Matrix Cancer-Associated Fibroblasts (eCAFs) Correlates with Poor ICB Response via Macrophage Chemotaxis Activation of Akt Signaling Pathway in Gastric Cancer	13
Age-Related Hormones Changes and Its Impact on Health Status and Lifespan	13
Metabolic Rewiring and Post-Translational Modifications: Unlocking the Mechanisms of Bone Turnover in Osteoporosis	13
Cell-Free DNA As Peripheral Biomarker of Alzheimer’s Disease	12
Ischemic Stroke and the Biological Hallmarks of Aging	12
Autophagy and Renal Fibrosis	12
Exploring the Intricate Nexus of Sarcopenia and Cognitive Impairment	11
Cerebellum and Aging: Update and Challenges	11
Pharmacological Mechanisms and Clinical Applications of Curcumin: Update	11
Novel Insights into the Roles and Mechanisms of GLP-1 Receptor Agonists against Aging-Related Diseases	11
Edge Density Imaging Identifies White Matter Biomarkers of Late-Life Obesity and Cognition	11
Perspectives on Movement and Eating Behaviours in Brazilian Elderly: An Analysis of Clusters Associated with Disease Outcomes	11
Aging and Sex Differences in Brain Volume and Cerebral Blood Flow	11
Roles of Ependymal Cells in the Physiology and Pathology of the Central Nervous System	11
P2Y1R silencing in Astrocytes Protected Neuroinflammation and Cognitive Decline in a Mouse Model of Alzheimer's Disease	11
PARP16-Mediated Stabilization of Amyloid Precursor Protein mRNA Exacerbates Alzheimer’s Disease Pathogenesis	11
Traveling Subject-Informed Harmonization Increases Reliability of Brain Diffusion Tensor and Neurite Mapping	11
Myocyte Enhancer Factor 2A Plays a Central Role in the Regulatory Networks of Cellular Physiopathology	11
Age-related Loss of miR-124 Causes Cognitive Deficits via Derepressing RyR3 Expression	11
Neuroinflammation as a Link in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis	11
ACE2 and COVID-19 Susceptibility and Severity	11
Targeting Sclerostin and Dkk1 at Optimized Proportions of Low-Dose Antibody Achieves Similar Skeletal Benefits to Higher-Dose Sclerostin Targeting in the Mature Adult and Aged Skeleton	11
The Impact of Rosemary and Ginger Extracts on Aging and Healthspan in Drosophila	10
The Impact of Aging on Neurological Diseases in the Elderly: Molecular Mechanisms and Therapeutic Perspectives	10
A Turning Point for China’s Population: No Child and Long Illness	10
Targeting SIRT2 in Aging-Associated Fibrosis Pathophysiology	10
New Insight into the Mechanism of Neurochemical Imbalance in Multiple Sclerosis: Abnormal Transportation of Brain Extracellular Space	10
Pericyte Dysfunction Contributes to Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats	10
Bone Health and Physical Activity - The Complex Mechanism	9
Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses	9
Influenza Virus-Induced Paracrine Cellular Senescence of the Lung Contributes to Enhanced Viral Load	9
Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases	9
Age and Sex Affect Essential Tremor (ET) Plus: Clinical Heterogeneity in ET Based on the National Survey in China	9
A Systematic Review of Intervention Trials Utilizing Biomarkers Among Informal Caregivers of People with Alzheimer's Disease & Related Dementias	9
Sarcopenic Obesity: An Emerging Public Health Problem, But an Answer Appears to Be Available	9
Telomeres: Dysfunction, Maintenance, Aging and Cancer	9
Osteoblastic Wls Ablation Protects Mice from Total Body Irradiation-Induced Impairments in Hematopoiesis and Bone Marrow Microenvironment	8
Microglia Exhibit Distinct Heterogeneity Rather than M1/M2 Polarization within the Early Stage of Acute Ischemic Stroke	8
Bidirectional Crosstalk between the Heart and Brain in Alzheimer's Disease	8
Modulation of Mitochondrial Dynamics by the Angiotensin System in Dopaminergic Neurons and Microglia	8
Role and Mechanism of Epigenetic Regulation in the Aging of Germ Cells: Prospects for Targeted Interventions	8
Advancements in Targeting Macrophage Senescence for Age-Associated Conditions	8
Response to Letter to the Editor, “Mechanical Ventilation in COVID-19 Patients: a question from Age to Frailty”	8
Pharmacological Blockade of NLRP3 Inflammasome/IL-1β-Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction	8
Impairment of the trans-Golgi-Lysosomal Pathway Accelerates Dopaminergic Neuronal Senescence in LRRK2R1627P Rats	8

Comment on: “Senolytic Treatment Improve Small Intestine Regeneration in Aging”	8
TAK1 Improves Cognitive Function via Suppressing RIPK1-Driven Neuronal Apoptosis and Necroptosis in Rats with Chronic Hypertension	8
Expert Consensus on the Application of Stem Cells in Psoriasis Research and Clinical Trials	8
Erratum to “Inhibition of Endoplasmic Reticulum Stress is Involved in the Neuroprotective Effect of bFGF in the 6-OHDA-Induced Parkinson’s Disease Model”	8
DR1 Activation Inhibits the Proliferation of Vascular Smooth Muscle Cells through Increasing Endogenous H2S in Diabetes	8
Mechanical Ventilation in COVID-19 Patients: a question from Age to Frailty	8
Farnesoid X receptor: From Structure to Function and Its Pharmacology in Liver Fibrosis	8
Involvement of Inheritance in Determining Telomere Length beyond Environmental and Lifestyle Factors	8
Challenges in Establishing Vaccine Induced Herd Immunity through Age Specific Community Vaccinations	7
Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity via AMPK/SOD2 Pathway	7
YAP/TAZ as Molecular Targets in Skeletal Muscle Atrophy and Osteoporosis	7
Citicoline for Supporting Memory in Aging Humans	7
Human APOE4 Protects High-Fat and High-Sucrose Diet Fed Targeted Replacement Mice against Fatty Liver Disease Compared to APOE3	7
Exosomes as a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion	7
Orthostatic Hypotension and Cognitive Function in Individuals 85 Years of Age: A Longitudinal Cohort Study in Sweden	7
DNA Demethylation of Promoter Region Facilitates Atoh-1-Induced Interleukin-19 Expression Activation in Bone Marrow Monocytes of Old Mice	7
Roles and Mechanisms of Astragaloside IV in Combating Neuronal Aging	7
Mitochondrial Dysfunction of Astrocytes Mediates Lipid Accumulation in Temporal Lobe Epilepsy	7
Decoding the Role of Familial Parkinson’s Disease-Related Genes in DNA Damage and Repair	7