OOIR: Observatory of International Research

Papers

(The median citation count of Cold Spring Harbor Perspectives in Medicine is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults	558
iPSC-RPE in Retinal Degeneration: Recent Advancements and Future Perspectives	349
Metabolic Signaling in Cancer	157
Developing New Vectors for Retinal Gene Therapy	62
Personalized Financial Planning Using Applied Genetics	42
Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer	36
Toward Retinal Organoids in High-Throughput	36
Pathomechanisms of Inherited Retinal Degeneration and Perspectives for Neuroprotection	35
Ovarian Clear Cell Carcinoma: An Endometriosis-Associated Cancer with Therapeutic Challenges	32
How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research	27
Embryological Insights into the Origin of Epithelial Cancers of the Female Reproductive Tract	26
Genetics and Epigenetics of Type 1 Diabetes Self-Reactive T Cells	26
Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes: Challenges, Choice, and Timing of Immunomodulators	24
From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments	22
Inflammatory β-Cell Stress and Immune Surveillance in Type 1 Diabetes	20
Mechanisms of Organ-Specific Metastasis of Breast Cancer	19
α-Synuclein in Parkinson's Disease: 12 Years Later	19
Retinal Disorders	18
Functional Neuroanatomy of the Normal and Pathological Basal Ganglia	17
Therapeutic Gene Editing in Inherited Retinal Disorders	17
Optogenetic Vision Restoration	16
Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development	16
Aging and Inflammation	15
Immunology of Retinitis Pigmentosa and Gene Therapy–Associated Uveitis	15
Autophagy and Protein Quality Control in Parkinson's Disease	14

Innate Immunity in Type 1 Diabetes	13
Endothelial Cell Differentiation and Hemogenic Specification	13
Evolutionary Approaches in Aging Research	12
The Pathogenesis of Type 1 Diabetes	12
Breast Cancer Immunity: It is TIME for the Next Chapter	12
Lipid Alterations and Pathogenic Roles in Synucleinopathies	11
Epitope Hierarchy in Type 1 Diabetes Pathogenesis	11
Acute Promyelocytic Leukemia, Retinoic Acid, and Arsenic: A Tale of Dualities	11
From Life Span to Health Span: Declaring “Victory” in the Pursuit of Human Longevity	11
The Funding Channels of Geroscience	11
Early Detection of Ovarian Cancer	10
Toward a Unified Theory of Why Young People Develop Cancer	10
The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes	10
Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk Evaluation	10
Lessons Learned from the Development of the First FDA-Approved Gene Therapy Drug, Voretigene Neparvovec-rzyl	10
Lymphatic Tissue and Organ Engineering for In Vitro Modeling and In Vivo Regeneration	10
T Cell Differentiation in Autoimmune Type 1 Diabetes	9
Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging	9
Comparison of Worldwide Disease Prevalence and Genetic Prevalence of Inherited Retinal Diseases and Variant Interpretation Considerations	9
Modeling Brain Vasculature Immune Interactions In Vitro	9
A History of Biosafety: U.S. Perspective	9
Endothelial Lipid Metabolism	9
Wnt/frizzled Signaling in Endothelium: A Major Player in Blood-Retinal- and Blood-Brain-Barrier Integrity	9
Understanding the Warburg Effect in Cancer	8
New Paradigms in the Clinical Management of Li–Fraumeni Syndrome	8
Technologies for Decoding Cancer Metabolism with Spatial Resolution	8
Dormancy in Breast Cancer	8
Emerging Therapies for Breast Cancer	8
The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer	8
Notch Signaling in Vascular Endothelial and Mural Cell Communications	8
Next-Generation Modeling of Cancer Using Organoids	8
Leucine-Rich Repeat Kinase 2: Pathways to Parkinson's Disease	7
Parallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor Microenvironment	7
History of Finding Genes and Mutations Causing Inherited Retinal Diseases	7
The Extraordinary Phenotypic and Genetic Variability of Retinal and Macular Degenerations: The Relevance to Therapeutic Developments	7
Retinal Degeneration Animal Models in Bardet–Biedl Syndrome and Related Ciliopathies	7
Cellular Origins and Lineage Plasticity in Cancer	7
Osteosarcoma through the Lens of Bone Development, Signaling, and Microenvironment	7
Rare Epithelial Ovarian Cancers: Low Grade Serous and Mucinous Carcinomas	7
Mechanics of Lymphatic Pumping and Lymphatic Function	7
Historical Perspectives of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies	7
Regulation of the Blood–Brain Barrier in Health and Disease	6
Human Endothelial Colony-Forming Cells	6
Angiogenesis and Microvascular Permeability	6
The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes	6
Beyond the NEI-VFQ: Recent Experience in the Development and Utilization of Patient-Reported Outcomes for Inherited Retinal Diseases	6
Lung Cancer Stem Cells and Their Clinical Implications	6
Canine and Feline Models of Inherited Retinal Diseases	6
Lymphedema and Obesity	6
Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges	5

Mobility Testing and Other Performance-Based Assessments of Functional Vision in Patients with Inherited Retinal Disease	5
Cell-Based Therapies: Strategies for Regeneration	5
Lymphatic Clearance and Pump Function	5
International Gains to Achieving Healthy Longevity	5
The Breast Cancer Proteome and Precision Oncology	5
Corrigendum: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse	5
Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease	5
Developmental Heterogeneity of Rhabdomyosarcoma	5
Advances in Making Cancer Mouse Models More Accessible and Informative through Non-Germline Genetic Engineering	5
Spatial Biology of Breast Cancer	5
The Role of Stroma in Cancer Metabolism	4
Cancer Therapies Targeting Cellular Metabolism	4
Imaging of Disease-Related Networks in Parkinson's Disease	4
Mendelian Randomization	4
Crowdfunding and Crowdsourcing of Aging Science	4
Metabolic Reprogramming in Human Cancer Patients and Patient-Derived Models	4
Tumor Immunology and Immunotherapy of Non-Small-Cell Lung Cancer	4
RPGR-Related Retinopathy: Clinical Features, Molecular Genetics, and Gene Replacement Therapy	4
From Bench to Bedside—Delivering Gene Therapy for Leber Hereditary Optic Neuropathy	4
Breakdown and Repair of Peripheral Immune Tolerance in Type 1 Diabetes	4
Restoration of Rod-Derived Metabolic and Redox Signaling to Prevent Blindness	4
Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond	4
Molecular Pathology of Lung Cancer	4
Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer	4
Threats from the Fungal Kingdom	4
The Role of the National Institute on Aging in the Development of the Field of Geroscience	3
Mechanisms Regulating T Cell–Endothelial Cell Interactions	3
Adoptive Cell Therapy for Pediatric Solid Tumors	3
Cancer Metabolism under Limiting Oxygen Conditions	3
Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy Responses	3
Biological Restraints on Indefinite Survival	3
Mitochondrial Targeted Interventions for Aging	3
Oncogenic Control of Metabolism	3
Gene Therapies for Retinitis Pigmentosa that Target Glucose Metabolism	3
Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions	3
Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and Consensus	3
Extracellular Matrix Regulation of Vascular Morphogenesis, Maturation, and Stabilization	3
Integrating Omics into Functional Biomarkers of Type 1 Diabetes	3
Endothelial Cell–Pericyte Interactions in the Pathogenesis of Cerebral Cavernous Malformations (CCMs)	3
Geroscience and Its Promise	3
Corrigendum: Toward Retinal Organoids in High-Throughput	3
Environmental Factors in Type 1 Diabetes	3
Imaging Tumor Metabolism	3
Trial by “Firsts”: Clinical Trial Design and Regulatory Considerations in the Development and Approval of the First AAV Gene Therapy Product in the United States	3
Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression	3
The Mitochondrial Connection in Parkinson's Disease	3