Cold Spring Harbor Perspectives in Medicine

Papers
(The median citation count of Cold Spring Harbor Perspectives in Medicine is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)
ArticleCitations
Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults168
Tuberculosis Drug Discovery in the Age of Artificial Intelligence103
iPSC-RPE in Retinal Degeneration: Recent Advancements and Future Perspectives46
Pathomechanisms of Inherited Retinal Degeneration and Perspectives for Neuroprotection43
Personalized Financial Planning Using Applied Genetics42
Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer36
Developing New Vectors for Retinal Gene Therapy34
Pediatric Tuberculosis: Epidemiology, Disease Spectrum, Diagnosis, and Management32
Toward Retinal Organoids in High-Throughput30
Metabolic Signaling in Cancer29
Ovarian Clear Cell Carcinoma: An Endometriosis-Associated Cancer with Therapeutic Challenges29
Embryological Insights into the Origin of Epithelial Cancers of the Female Reproductive Tract25
How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research22
Inflammatory β-Cell Stress and Immune Surveillance in Type 1 Diabetes22
α-Synuclein in Parkinson's Disease: 12 Years Later21
From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments20
Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes: Challenges, Choice, and Timing of Immunomodulators18
Genetics and Epigenetics of Type 1 Diabetes Self-Reactive T Cells18
Functional Neuroanatomy of the Normal and Pathological Basal Ganglia17
Retinal Disorders17
Mechanisms of Organ-Specific Metastasis of Breast Cancer17
Therapeutic Gene Editing in Inherited Retinal Disorders17
Optogenetic Vision Restoration16
Aging and Inflammation16
Endothelial Cell Differentiation and Hemogenic Specification15
Who Are the Space Invaders? Planetary Protection and the Role of Biological Interactions between Extraterrestrial and Terrestrial Biospheres15
Immunology of Retinitis Pigmentosa and Gene Therapy–Associated Uveitis14
Innate Immunity in Type 1 Diabetes14
Autophagy and Protein Quality Control in Parkinson's Disease14
Epitope Hierarchy in Type 1 Diabetes Pathogenesis13
Lipid Alterations and Pathogenic Roles in Synucleinopathies13
The Pathogenesis of Type 1 Diabetes13
Breast Cancer Immunity: It is TIME for the Next Chapter12
Evolutionary Approaches in Aging Research12
The Funding Channels of Geroscience12
Models of High-Grade Serous Ovarian Carcinoma12
Acute Promyelocytic Leukemia, Retinoic Acid, and Arsenic: A Tale of Dualities12
Lessons Learned from the Development of the First FDA-Approved Gene Therapy Drug, Voretigene Neparvovec-rzyl11
Lymphatic Tissue and Organ Engineering for In Vitro Modeling and In Vivo Regeneration10
A History of Biosafety: U.S. Perspective10
Modeling Brain Vasculature Immune Interactions In Vitro10
From Life Span to Health Span: Declaring “Victory” in the Pursuit of Human Longevity10
Wnt/frizzled Signaling in Endothelium: A Major Player in Blood-Retinal- and Blood-Brain-Barrier Integrity10
The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes10
Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk Evaluation10
Toward a Unified Theory of Why Young People Develop Cancer10
Early Detection of Ovarian Cancer10
Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging10
Retinal Degeneration Animal Models in Bardet–Biedl Syndrome and Related Ciliopathies9
New Paradigms in the Clinical Management of Li–Fraumeni Syndrome9
Leucine-Rich Repeat Kinase 2: Pathways to Parkinson's Disease9
Endothelial Lipid Metabolism9
The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer9
Emerging Therapies for Breast Cancer9
Notch Signaling in Vascular Endothelial and Mural Cell Communications9
Technologies for Decoding Cancer Metabolism with Spatial Resolution9
Understanding the Warburg Effect in Cancer9
T Cell Differentiation in Autoimmune Type 1 Diabetes9
Rare Epithelial Ovarian Cancers: Low Grade Serous and Mucinous Carcinomas9
Next-Generation Modeling of Cancer Using Organoids9
Dormancy in Breast Cancer9
Comparison of Worldwide Disease Prevalence and Genetic Prevalence of Inherited Retinal Diseases and Variant Interpretation Considerations9
Safety and Security in the Lithotroph of Microbiology—A Commentary8
Cellular Origins and Lineage Plasticity in Cancer8
Historical Perspectives of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies8
Osteosarcoma through the Lens of Bone Development, Signaling, and Microenvironment8
Parallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor Microenvironment8
History of Finding Genes and Mutations Causing Inherited Retinal Diseases8
Angiogenesis and Microvascular Permeability8
The Extraordinary Phenotypic and Genetic Variability of Retinal and Macular Degenerations: The Relevance to Therapeutic Developments8
Mechanics of Lymphatic Pumping and Lymphatic Function8
The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes8
Parkinson's Disease, Second Edition7
Regulation of the Blood–Brain Barrier in Health and Disease7
Mobility Testing and Other Performance-Based Assessments of Functional Vision in Patients with Inherited Retinal Disease7
Canine and Feline Models of Inherited Retinal Diseases7
Lymphedema and Obesity7
Corrigendum: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse7
Beyond the NEI-VFQ: Recent Experience in the Development and Utilization of Patient-Reported Outcomes for Inherited Retinal Diseases7
Human Endothelial Colony-Forming Cells7
Advances in Making Cancer Mouse Models More Accessible and Informative through Non-Germline Genetic Engineering7
Cell-Based Therapies: Strategies for Regeneration6
The Breast Cancer Proteome and Precision Oncology6
Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond6
International Gains to Achieving Healthy Longevity6
RPGR-Related Retinopathy: Clinical Features, Molecular Genetics, and Gene Replacement Therapy6
Spatial Biology of Breast Cancer6
Developmental Heterogeneity of Rhabdomyosarcoma6
Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges6
Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease6
Imaging of Disease-Related Networks in Parkinson's Disease6
Lymphatic Clearance and Pump Function6
From Bench to Bedside—Delivering Gene Therapy for Leber Hereditary Optic Neuropathy5
Breakdown and Repair of Peripheral Immune Tolerance in Type 1 Diabetes5
Restoration of Rod-Derived Metabolic and Redox Signaling to Prevent Blindness5
The Mitochondrial Connection in Parkinson's Disease5
From Phagosomes to Niches: Macrophage Biology in Tuberculosis Revisited5
Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer5
Effector Functions of Conventional and Unconventional Mycobacterium tuberculosis ( Mtb )-Specific T Cells5
Threats from the Fungal Kingdom5
Extracellular Matrix Regulation of Vascular Morphogenesis, Maturation, and Stabilization5
Biological Restraints on Indefinite Survival5
Cancer Therapies Targeting Cellular Metabolism5
Metabolic Reprogramming in Human Cancer Patients and Patient-Derived Models5
Crowdfunding and Crowdsourcing of Aging Science5
The Role of Stroma in Cancer Metabolism5
Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression5
Trial by “Firsts”: Clinical Trial Design and Regulatory Considerations in the Development and Approval of the First AAV Gene Therapy Product in the United States4
Addendum to Dopamine Cell-Based Replacement Therapies4
Imaging Tumor Metabolism4
Cancer Metabolism under Limiting Oxygen Conditions4
Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy Responses4
Gene Therapies for Retinitis Pigmentosa that Target Glucose Metabolism4
Mitochondrial Targeted Interventions for Aging4
Integrating Omics into Functional Biomarkers of Type 1 Diabetes4
The Role of the National Institute on Aging in the Development of the Field of Geroscience4
Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions4
Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and Consensus4
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