Cold Spring Harbor Perspectives in Medicine

Papers
(The median citation count of Cold Spring Harbor Perspectives in Medicine is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)
ArticleCitations
Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults143
Tuberculosis Drug Discovery in the Age of Artificial Intelligence50
Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer49
iPSC-RPE in Retinal Degeneration: Recent Advancements and Future Perspectives49
Pathomechanisms of Inherited Retinal Degeneration and Perspectives for Neuroprotection42
Toward Retinal Organoids in High-Throughput38
Pediatric Tuberculosis: Epidemiology, Disease Spectrum, Diagnosis, and Management38
Personalized Financial Planning Using Applied Genetics37
Metabolic Signaling in Cancer37
Ovarian Clear Cell Carcinoma: An Endometriosis-Associated Cancer with Therapeutic Challenges31
Developing New Vectors for Retinal Gene Therapy29
Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes: Challenges, Choice, and Timing of Immunomodulators24
Embryological Insights into the Origin of Epithelial Cancers of the Female Reproductive Tract24
Genetics and Epigenetics of Type 1 Diabetes Self-Reactive T Cells22
How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research22
Mechanisms of Organ-Specific Metastasis of Breast Cancer21
Inflammatory β-Cell Stress and Immune Surveillance in Type 1 Diabetes21
From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments21
Host Biomarkers in Tuberculosis20
α-Synuclein in Parkinson's Disease: 12 Years Later18
Therapeutic Gene Editing in Inherited Retinal Disorders18
Retinal Disorders18
Functional Neuroanatomy of the Normal and Pathological Basal Ganglia16
Imaging Modalities in Tuberculosis16
Optogenetic Vision Restoration16
Who Are the Space Invaders? Planetary Protection and the Role of Biological Interactions between Extraterrestrial and Terrestrial Biospheres15
Aging and Inflammation15
Innate Immunity in Type 1 Diabetes15
Autophagy and Protein Quality Control in Parkinson's Disease15
Immunology of Retinitis Pigmentosa and Gene Therapy–Associated Uveitis14
Lipid Alterations and Pathogenic Roles in Synucleinopathies13
Epitope Hierarchy in Type 1 Diabetes Pathogenesis13
Breast Cancer Immunity: It is TIME for the Next Chapter13
The Funding Channels of Geroscience13
Evolutionary Approaches in Aging Research13
Models of High-Grade Serous Ovarian Carcinoma12
Early Detection of Ovarian Cancer12
Lessons Learned from the Development of the First FDA-Approved Gene Therapy Drug, Voretigene Neparvovec-rzyl12
Acute Promyelocytic Leukemia, Retinoic Acid, and Arsenic: A Tale of Dualities12
Modeling Brain Vasculature Immune Interactions In Vitro11
From Life Span to Health Span: Declaring “Victory” in the Pursuit of Human Longevity11
Toward a Unified Theory of Why Young People Develop Cancer11
A History of Biosafety: U.S. Perspective11
Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk Evaluation11
The Pathogenesis of Type 1 Diabetes11
The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes11
T Cell Differentiation in Autoimmune Type 1 Diabetes11
Dormancy in Breast Cancer10
Emerging Therapies for Breast Cancer10
The Mouse Model of Tuberculosis: Uses and Abuses10
Comparison of Worldwide Disease Prevalence and Genetic Prevalence of Inherited Retinal Diseases and Variant Interpretation Considerations10
Understanding the Warburg Effect in Cancer10
New Paradigms in the Clinical Management of Li–Fraumeni Syndrome10
Technologies for Decoding Cancer Metabolism with Spatial Resolution10
Next-Generation Modeling of Cancer Using Organoids10
The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer10
Notch Signaling in Vascular Endothelial and Mural Cell Communications10
Retinal Degeneration Animal Models in Bardet–Biedl Syndrome and Related Ciliopathies10
Update on Tuberculosis Treatment and Drug Regimens9
Parallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor Microenvironment9
The Global Epidemiology of Tuberculosis: Burden, Trends, and Determinants9
Historical Perspectives of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies9
The Extraordinary Phenotypic and Genetic Variability of Retinal and Macular Degenerations: The Relevance to Therapeutic Developments9
Leucine-Rich Repeat Kinase 2: Pathways to Parkinson's Disease9
Rare Epithelial Ovarian Cancers: Low Grade Serous and Mucinous Carcinomas9
History of Finding Genes and Mutations Causing Inherited Retinal Diseases9
Diagnostic Assays for TB Disease and Drug Resistance Detection—Advances and Latest WHO Recommendations9
Safety and Security in the Lithotroph of Microbiology—A Commentary9
Cellular Origins and Lineage Plasticity in Cancer9
Osteosarcoma through the Lens of Bone Development, Signaling, and Microenvironment9
Angiogenesis and Microvascular Permeability9
Immunodominant Tuberculosis Antigens Recognized by Human CD4 + and CD8 + T Cells8
Parkinson's Disease, Second Edition8
Mechanics of Lymphatic Pumping and Lymphatic Function8
Regulation of the Blood–Brain Barrier in Health and Disease8
Host Cell Death Signaling Pathways Manipulated by Mycobacterium tuberculosis8
The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes8
Mobility Testing and Other Performance-Based Assessments of Functional Vision in Patients with Inherited Retinal Disease8
Beyond the NEI-VFQ: Recent Experience in the Development and Utilization of Patient-Reported Outcomes for Inherited Retinal Diseases8
Canine and Feline Models of Inherited Retinal Diseases8
The Breast Cancer Proteome and Precision Oncology7
Developmental Heterogeneity of Rhabdomyosarcoma7
Cell-Based Therapies: Strategies for Regeneration7
Corrigendum: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse7
From Empirical Discovery to Targeted Therapy: The Evolution of Tuberculosis Treatment7
Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges7
International Gains to Achieving Healthy Longevity7
Advances in Making Cancer Mouse Models More Accessible and Informative through Non-Germline Genetic Engineering7
Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease6
Spatial Biology of Breast Cancer6
Metabolic Reprogramming in Human Cancer Patients and Patient-Derived Models6
Lymphatic Clearance and Pump Function6
RPGR-Related Retinopathy: Clinical Features, Molecular Genetics, and Gene Replacement Therapy6
Imaging of Disease-Related Networks in Parkinson's Disease6
Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond6
Effector Functions of Conventional and Unconventional Mycobacterium tuberculosis ( Mtb )-Specific T Cells6
Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer5
Breakdown and Repair of Peripheral Immune Tolerance in Type 1 Diabetes5
Extracellular Matrix Regulation of Vascular Morphogenesis, Maturation, and Stabilization5
From Bench to Bedside—Delivering Gene Therapy for Leber Hereditary Optic Neuropathy5
Threats from the Fungal Kingdom5
From Phagosomes to Niches: Macrophage Biology in Tuberculosis Revisited5
Biological Restraints on Indefinite Survival5
Cancer Therapies Targeting Cellular Metabolism5
Crowdfunding and Crowdsourcing of Aging Science5
The Role of Stroma in Cancer Metabolism5
Restoration of Rod-Derived Metabolic and Redox Signaling to Prevent Blindness5
The Mitochondrial Connection in Parkinson's Disease4
The Role of the National Institute on Aging in the Development of the Field of Geroscience4
Imaging Tumor Metabolism4
Integrating Omics into Functional Biomarkers of Type 1 Diabetes4
Addendum to Dopamine Cell-Based Replacement Therapies4
Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression4
Diagnosing Tuberculosis Infection: From the Host to the Pathogen4
Gene Therapies for Retinitis Pigmentosa that Target Glucose Metabolism4
Host-Directed Therapies for Tuberculosis4
Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy Responses4
Trial by “Firsts”: Clinical Trial Design and Regulatory Considerations in the Development and Approval of the First AAV Gene Therapy Product in the United States4
Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and Consensus4
Cancer Metabolism under Limiting Oxygen Conditions4
Mitochondrial Targeted Interventions for Aging4
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