Cold Spring Harbor Perspectives in Medicine

Papers
(The median citation count of Cold Spring Harbor Perspectives in Medicine is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
Knowledge-Based Therapeutics for Tricarboxylic Acid (TCA) Cycle-Deficient Cancers464
Oncogenic Control of Metabolism291
Adoptive Cell Therapy for Pediatric Solid Tumors148
Type 1 Diabetes: Advances in Understanding and Treatment 100 Years after the Discovery of Insulin35
The Teplizumab Saga: The Challenge of Not Getting Lost in Clinical Translation34
Gene-Expression Profiling to Decipher Breast Cancer Inter- and Intratumor Heterogeneity31
The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes30
Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions29
Addressing Biological Questions with Preclinical Cancer Imaging20
Corrigendum: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse20
Toward a Unified Theory of Why Young People Develop Cancer19
Epidemiology and Risk Factors for Breast Cancer: 21st Century Advances, Gaps to Address through Interdisciplinary Science19
Advances in Making Cancer Mouse Models More Accessible and Informative through Non-Germline Genetic Engineering18
Lymphatic Tissue and Organ Engineering for In Vitro Modeling and In Vivo Regeneration15
iPSC-RPE in Retinal Degeneration: Recent Advancements and Future Perspectives14
Geroscience and Its Promise13
Endothelial Cell–Pericyte Interactions in the Pathogenesis of Cerebral Cavernous Malformations (CCMs)13
Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk Evaluation12
The Breast Cancer Proteome and Precision Oncology12
Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges11
International Gains to Achieving Healthy Longevity11
Choroideremia: Toward Regulatory Approval of Retinal Gene Therapy10
Mobility Testing and Other Performance-Based Assessments of Functional Vision in Patients with Inherited Retinal Disease10
Immunometabolic Maladaptations to the Tumor Microenvironment10
Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease9
Mechanisms Regulating T Cell–Endothelial Cell Interactions9
Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults9
Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging9
Advances in Islet Transplantation and the Future of Stem Cell–Derived Islets to Treat Diabetes9
Developmental Heterogeneity of Rhabdomyosarcoma9
Prostanoids Regulate Angiogenesis and Lymphangiogenesis in Pathological Conditions8
Modeling Brain Vasculature Immune Interactions In Vitro8
Environmental Factors in Type 1 Diabetes8
The Emerging Role of the Single-Cell and Spatial Tumor Microenvironment in High-Grade Serous Ovarian Cancer8
Developmental Modeling of Childhood Cancers8
Developing New Vectors for Retinal Gene Therapy7
Cell-Based Therapies: Strategies for Regeneration7
Advances in Studying Cancer Immunology in Mice7
Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer7
MicroRNAs in Mechanical Homeostasis7
Wnt/frizzled Signaling in Endothelium: A Major Player in Blood-Retinal- and Blood-Brain-Barrier Integrity7
Imaging of Disease-Related Networks in Parkinson's Disease6
Targeting Hyperactive Ras Signaling in Pediatric Cancer6
Lymphatic Clearance and Pump Function6
Lung Cancer Computational Biology and Resources6
X-Linked Retinoschisis6
Spatial Biology of Breast Cancer6
Role of Tumor Cell Intrinsic and Host Autophagy in Cancer5
Understanding the Warburg Effect in Cancer5
Imaging Approaches in Cancer Biology5
Ovarian Clear Cell Carcinoma: An Endometriosis-Associated Cancer with Therapeutic Challenges5
Molecular Mechanisms Driving Lymphedema and Other Lymphatic Anomalies5
Overview of Retinal Gene Therapy: Current Status and Future Challenges5
Metabolic Signaling in Cancer5
Signal Transduction and Gene Regulation in the Endothelium5
Corrigendum: Toward Retinal Organoids in High-Throughput5
Personalized Financial Planning Using Applied Genetics5
T Cell Differentiation in Autoimmune Type 1 Diabetes4
Molecular Pathology of Lung Cancer4
Notch Signaling in the Vasculature: Angiogenesis and Angiocrine Functions4
Discovering Biological Mechanisms of Exceptional Human Health Span and Life Span4
Endothelial Lipid Metabolism4
Advancing Animal Models of Human Type 1 Diabetes4
Epigenetic Therapies4
Comparison of Worldwide Disease Prevalence and Genetic Prevalence of Inherited Retinal Diseases and Variant Interpretation Considerations4
Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond4
Prevention of Epithelial Ovarian Cancer4
Human Genomics and Drug Development4
Pathomechanisms of Inherited Retinal Degeneration and Perspectives for Neuroprotection4
Dormancy in Breast Cancer3
Mendelian Randomization3
Retinal Degeneration Animal Models in Bardet–Biedl Syndrome and Related Ciliopathies3
Inflammatory β-Cell Stress and Immune Surveillance in Type 1 Diabetes3
Cancer Therapies Targeting Cellular Metabolism3
From Bench to Bedside—Delivering Gene Therapy for Leber Hereditary Optic Neuropathy3
RPGR-Related Retinopathy: Clinical Features, Molecular Genetics, and Gene Replacement Therapy3
The Role of B Lymphocytes in Type 1 Diabetes3
The Evolution and Biology of SARS-CoV-2 Variants3
Monogenic Type 1 Diabetes: A High Yield Pool in Which to Discover New Mechanisms and Candidate Therapeutics for Type 1 Diabetes3
Technologies for Decoding Cancer Metabolism with Spatial Resolution3
The Complex Roles of Redox and Antioxidant Biology in Cancer3
How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research3
Toward Retinal Organoids in High-Throughput3
Tumor Immunology and Immunotherapy of Non-Small-Cell Lung Cancer3
Breast Cancer3
Lessons Learned from Cancer Metabolism for Physiology and Disease3
Next-Generation Modeling of Cancer Using Organoids3
Metabolic Reprogramming in Human Cancer Patients and Patient-Derived Models3
Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-192
The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer2
Pig Models in Retinal Research and Retinal Disease2
Embryological Insights into the Origin of Epithelial Cancers of the Female Reproductive Tract2
α-Synuclein in Parkinson's Disease: 12 Years Later2
Mechanisms of Organ-Specific Metastasis of Breast Cancer2
From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments2
Gut Microbiota and the Microvasculature2
Breast Cancer Histopathology in the Age of Molecular Oncology2
Targeting Angiogenesis via Resolution of Inflammation2
Lineage-Selective Dependencies in Pediatric Cancers2
Cancer Metabolism: Aspirations for the Coming Decade2
Multidimensional Imaging of Breast Cancer2
Considerations for Developing an Autologous Induced Pluripotent Stem Cell (iPSC)-Derived Retinal Pigment Epithelium (RPE) Replacement Therapy2
Patient-Derived-Xenografts in Mice: A Preclinical Platform for Cancer Research2
Emerging Therapies for Breast Cancer2
Modeling Parkinson's Disease in Primates2
The Importance of Natural History Studies in Inherited Retinal Diseases2
Genetics and Epigenetics of Type 1 Diabetes Self-Reactive T Cells2
A Systematic Review of Optogenetic Vision Restoration: History, Challenges, and New Inventions from Bench to Bedside2
Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes: Challenges, Choice, and Timing of Immunomodulators2
New Paradigms in the Clinical Management of Li–Fraumeni Syndrome2
Functional Neuroanatomy of the Normal and Pathological Basal Ganglia1
Breakdown and Repair of Peripheral Immune Tolerance in Type 1 Diabetes1
Aging and Inflammation1
Parallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor Microenvironment1
Mitochondria and Cancer1
The Beauty and Complexity of Blood Vessel Patterning1
Neurotrophic Factors in the Treatment of Inherited Retinal Diseases1
Extracellular Matrix Regulation of Vascular Morphogenesis, Maturation, and Stabilization1
Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer1
Roles of NAD+in Health and Aging1
Advances in Immunocompetent Mouse and Rat Models1
The Role of Stroma in Cancer Metabolism1
Rare Epithelial Ovarian Cancers: Low Grade Serous and Mucinous Carcinomas1
Retinal Disorders1
Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development1
Lymphatic Vascular Permeability1
Cancer Metabolism: Historical Landmarks, New Concepts, and Opportunities1
Approaches to Study Tumor Metabolism in Mice1
Progression in Parkinson's Disease1
Resistance and Resilience to Alzheimer's Disease1
Alternative RNA Splicing in the Retina: Insights and Perspectives1
The Gut–Brain Axis in Parkinson's Disease1
Cellular Origins and Lineage Plasticity in Cancer1
Notch Signaling in Vascular Endothelial and Mural Cell Communications1
Therapeutic Gene Editing in Inherited Retinal Disorders1
The Extraordinary Phenotypic and Genetic Variability of Retinal and Macular Degenerations: The Relevance to Therapeutic Developments1
Threats from the Fungal Kingdom1
Restoration of Rod-Derived Metabolic and Redox Signaling to Prevent Blindness1
Autoantigen-Specific Immunotherapies for the Prevention and Treatment of Type 1 Diabetes1
Pathophysiology of Motor Control Abnormalities in Parkinson's Disease1
Rodent Models of Retinal Degeneration: From Purified Cells in Culture to Living Animals1
Optogenetic Vision Restoration1
Pediatric Cancer Drug Development: Leveraging Insights in Cancer Biology and the Evolving Regulatory Landscape to Address Challenges and Guide Further Progress1
Crowdfunding and Crowdsourcing of Aging Science1
Corrigendum: Modeling Parkinson's Disease in Primates1
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