OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biomedical Engineering is 78. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	586
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array	409
Emergency delivery of particulate drugs by active ejection using in vivo wireless devices	356
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	345
Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	314
An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains	293
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence	272
Sensitive detection of SARS-CoV-2 on paper	260
Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders	259
A data-efficient strategy for building high-performing medical foundation models	258
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria	249
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2	225
A strain-programmed patch for the healing of diabetic wounds	221
Linking the genotypes and phenotypes of cancer cells in heterogenous populations via real-time optical tagging and image analysis	213
FAS-less allogeneic CAR T cells	208
Publisher Correction: Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation	208
Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord	207
A generative model uses healthy and diseased image pairs for pixel-level chest X-ray pathology localization	205
Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats	204
Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries	199
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity	197
Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	195
Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases	183
Ultrasensitive and long-lasting bioluminescence immunoassay for point-of-care viral antigen detection	181
Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer	174

A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide	173
Streamlining point-of-care assays	170
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease	169
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia	169
Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage	166
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells	163
Fast and sensitive electromechanical sensing	163
Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions	162
Faster detection of somatic structural variants	161
Probing when dCas9 tolerates DNA mismatches	152
Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody–STING agonist conjugates	148
Simultaneous visualization of multiple radionuclides in vivo	143
Making fitter cells and tissues	140
A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths	139
Offbeat drug-delivery tactics	136
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies	132
Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker	132
Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment	132
Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor	129
Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts	128
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver	124
An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity	123
A base editor for the long-term restoration of auditory function in mice with recessive profound deafness	123
Targeting inflammation with chimeric antigen receptor macrophages using a signal switch	117
A two-phase point-of-care diagnostic device for bladder cancer	116
A knockout run for CRISPRed cells	116
Sensing haemodynamics via wearables in sync	114
Subcutaneous pancreatic islet transplantation without immunosuppression	114
Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes	113
Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes	111
A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	108
Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation	108
Nanobody-based bispecific antibody engagers targeting CTLA-4 or PD-L1 for cancer immunotherapy	105
An off-the-shelf otoacoustic-emission probe for hearing screening via a smartphone	102
1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain	102
Targeting vaccines to dendritic cells by mimicking the processing and presentation of antigens in xenotransplant rejection	99
Making MRI increasingly useful	98
A bilingual speech neuroprosthesis driven by cortical articulatory representations shared between languages	96
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution	96
Reprogramming of fibroblasts into expandable cardiovascular progenitor cells via small molecules in xeno-free conditions	95
Straightforward, inexpensive and sensitive	94
Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors	91
Deep screening of antibody–antigen affinities	91
Mutation corrections in spinal muscular atrophy	91
Ablation of FAS confers allogeneic CD3– CAR T cells with resistance to rejection by T cells and natural killer cells	85
CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers	85
An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis	83
Opportunities and challenges in the development of exoskeletons for locomotor assistance	82
Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity	81
Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS–STING pathway	80

Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells	79
Targeted desialylation and cytolysis of tumour cells by fusing a sialidase to a bispecific T-cell engager	79
Author Correction: Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTENmRNA	79
Profiling protein–protein interactions to predict the efficacy of B-cell-lymphoma-2-homology-3 mimetics for acute myeloid leukaemia	78
Eyeing severe diabetes upfront	78
Rapid adaptation of brain–computer interfaces to new neuronal ensembles or participants via generative modelling	78