OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biomedical Engineering is 86. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
The evolution of commercial drug delivery technologies	583
Data-efficient and weakly supervised computational pathology on whole-slide images	572
CRISPR-based diagnostics	518
Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA	441
An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers	320
Pre-symptomatic detection of COVID-19 from smartwatch data	301
Synthetic data in machine learning for medicine and healthcare	265
A wearable electrochemical biosensor for the monitoring of metabolites and nutrients	261
Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors	242
High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays	229
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics	225
Integrating spatial gene expression and breast tumour morphology via deep learning	202
Rapid lateral flow immunoassay for the fluorescence detection of SARS-CoV-2 RNA	196
An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid	191
Microneedle patch for the ultrasensitive quantification of protein biomarkers in interstitial fluid	184
Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery	179
Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs	176
Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel	174
A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback	174
Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets	167
A multi-organ chip with matured tissue niches linked by vascular flow	164
Prolonged activation of innate immune pathways by a polyvalent STING agonist	163
Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples	162
Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations	161
Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles	161

Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device	160
Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients	159
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning	155
Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity	154
Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue	152
Wireless and battery-free technologies for neuroengineering	148
A deep-learning system for the assessment of cardiovascular disease risk via the measurement of retinal-vessel calibre	135
Sensitive fluorescence detection of SARS-CoV-2 RNA in clinical samples via one-pot isothermal ligation and transcription	134
Intravital three-dimensional bioprinting	133
Deep-learning models for the detection and incidence prediction of chronic kidney disease and type 2 diabetes from retinal fundus images	128
The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans	126
Self-supervised learning in medicine and healthcare	123
Open resource of clinical data from patients with pneumonia for the prediction of COVID-19 outcomes via deep learning	122
Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a	121
A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma	121
Prospective assessment of breast cancer risk from multimodal multiview ultrasound images via clinically applicable deep learning	114
Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow	113
Ultrasensitive high-resolution profiling of early seroconversion in patients with COVID-19	111
Extensive germline genome engineering in pigs	110
Restoration of sensory information via bionic hands	109
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine	108
Transdermal microneedles for the programmable burst release of multiple vaccine payloads	108
Toward higher-performance bionic limbs for wider clinical use	108
Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays	107
A portable scanner for magnetic resonance imaging of the brain	106
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure	106
Identification of psychiatric disorder subtypes from functional connectivity patterns in resting-state electroencephalography	105
Cryomicroneedles for transdermal cell delivery	104
A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images	103
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity	103
Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes	102
Combination of tumour-infarction therapy and chemotherapy via the co-delivery of doxorubicin and thrombin encapsulated in tumour-targeted nanoparticles	101
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance	100
Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies	100
Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel	98
Rapid manufacturing of non-activated potent CAR T cells	97
Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice	96
Design and clinical implementation of an open-source bionic leg	96
Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells	95
Massively parallel functional photoacoustic computed tomography of the human brain	95
Injectable and conductive cardiac patches repair infarcted myocardium in rats and minipigs	95
Exosome-eluting stents for vascular healing after ischaemic injury	95
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution	94
Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation	93
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma	93
Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma	93
Neutralizing antibodies for the treatment of COVID-19	93
Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy	93
Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates	92
A strain-programmed patch for the healing of diabetic wounds	91

A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves	90
Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases	90
Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window	90
Control of the activity of CAR-T cells within tumours via focused ultrasound	90
A fidget spinner for the point-of-care diagnosis of urinary tract infection	89
Shifting machine learning for healthcare from development to deployment and from models to data	88
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing	87
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours	86
Classification of T-cell activation via autofluorescence lifetime imaging	86
Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria	86
A web tool for the design of prime-editing guide RNAs	86