OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biomedical Engineering is 85. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	815
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	511
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array	426
Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	358
Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes	318
A data-efficient strategy for building high-performing medical foundation models	314
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2	306
Author Correction: Prolonged activation of innate immune pathways by a polyvalent STING agonist	297
An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains	276
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence	267
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria	247
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma	243
Sensitive detection of SARS-CoV-2 on paper	227
Solid stress impairs lymphocyte infiltration into lymph-node metastases	216
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics	208
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure	203
A strain-programmed patch for the healing of diabetic wounds	201
Adaptive adversarial neural networks for the analysis of lossy and domain-shifted datasets of medical images	194
Linking the genotypes and phenotypes of cancer cells in heterogenous populations via real-time optical tagging and image analysis	193
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia	189
Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases	183
Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries	182
Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats	182
Publisher Correction: Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation	181
Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer	179

Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord	172
FAS-less allogeneic CAR T cells	172
Streamlining point-of-care assays	171
Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage	169
Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	169
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease	166
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells	165
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity	162
Fast and sensitive electromechanical sensing	161
Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions	156
Simultaneous visualization of multiple radionuclides in vivo	155
Faster detection of somatic structural variants	153
Probing when dCas9 tolerates DNA mismatches	150
Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor	148
Offbeat drug-delivery tactics	145
An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity	144
Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker	143
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies	143
A base editor for the long-term restoration of auditory function in mice with recessive profound deafness	142
Making fitter cells and tissues	140
Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment	135
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver	134
A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths	133
Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts	131
A knockout run for CRISPRed cells	130
A two-phase point-of-care diagnostic device for bladder cancer	129
Subcutaneous pancreatic islet transplantation without immunosuppression	127
Sensing haemodynamics via wearables in sync	127
Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation	124
Making MRI increasingly useful	123
An off-the-shelf otoacoustic-emission probe for hearing screening via a smartphone	121
Reprogramming of fibroblasts into expandable cardiovascular progenitor cells via small molecules in xeno-free conditions	121
Targeting vaccines to dendritic cells by mimicking the processing and presentation of antigens in xenotransplant rejection	119
Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells	118
1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain	118
A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	116
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution	114
Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes	111
Mapping tissue heterogeneity in solid tumours using PET–MRI and machine learning	108
A bilingual speech neuroprosthesis driven by cortical articulatory representations shared between languages	108
Machine learning in translation	106
Straightforward, inexpensive and sensitive	104
Mutation corrections in spinal muscular atrophy	103
Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells	101
Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells	100
Deep screening of antibody–antigen affinities	100
Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors	99
Author Correction: Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTENmRNA	99
Eyeing severe diabetes upfront	99
Ablation of FAS confers allogeneic CD3– CAR T cells with resistance to rejection by T cells and natural killer cells	98

Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting	98
Targeted desialylation and cytolysis of tumour cells by fusing a sialidase to a bispecific T-cell engager	97
A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice	95
Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS–STING pathway	93
Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity	92
CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers	90
Rapid adaptation of brain–computer interfaces to new neuronal ensembles or participants via generative modelling	89
An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis	89
Opportunities and challenges in the development of exoskeletons for locomotor assistance	88
Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes	87
A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature	85