OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biomedical Engineering is 77. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Sensitive detection of SARS-CoV-2 on paper	792
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	554
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	513
Single-nucleus transcriptomics of an engineered pig model reveals microglia–T cell interactions driving Huntington’s disease neurodegeneration	373
Emergency delivery of particulate drugs by active ejection using in vivo wireless devices	359
Perilesional neuromodulation replaces lost sensorimotor function in persons with spinal cord injury	345
Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	316
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2	308
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array	300
An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains	283
Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders	268
Brain–heart–eye axis revealed by multi-organ imaging genetics and proteomics	246
A data-efficient strategy for building high-performing medical foundation models	245
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence	235
Human gastric multi-regional assembloids for functional parietal maturation and patient-specific modelling of antral foveolar hyperplasia	232
A strain-programmed patch for the healing of diabetic wounds	227
A generative model uses healthy and diseased image pairs for pixel-level chest X-ray pathology localization	218
FAS-less allogeneic CAR T cells	213
Streamlining point-of-care assays	201
Three-dimensional architecture of human bone marrow	198
Ultrasensitive and long-lasting bioluminescence immunoassay for point-of-care viral antigen detection	181
Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	176
Autonomous ultrasound with UltraBot	170
Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer	166
Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord	156

Low-input deep learning platform for citrullinated peptide identification, autoantigen discovery and rheumatoid arthritis treatment stratification	155
Publisher Correction: Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation	155
Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases	151
A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide	151
Systematic functional screening of switchable aptamer beacon probes	148
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells	148
Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries	142
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease	141
Faster detection of somatic structural variants	135
Towards generalizable AI in medicine via Generalist–Specialist Collaboration	133
Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment	133
Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor	131
A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths	129
A warm introduction	127
Offbeat drug-delivery tactics	124
Engineered non-expansive matrix for blood vessel organoid development and ischaemic stroke repair	122
Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions	120
Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis	119
Anchored random reverse primer sequencing for quantitative detection of novel gene fusions	118
Probing when dCas9 tolerates DNA mismatches	116
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies	110
Publisher Correction: Large-scale generation of iNK and CAR-iNK cells from CD34+ haematopoietic stem and progenitor cells for adoptive immunotherapy	109
LDL-binding IL-10 reduces vascular inflammation in atherosclerotic mice	108
A filamentary soft robotic probe for multimodal in utero monitoring of fetal health	107
Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts	104
A base editor for the long-term restoration of auditory function in mice with recessive profound deafness	102
Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody–STING agonist conjugates	100
Engineering challenges and translational opportunities in emerging gene delivery platforms	96
Targeting inflammation with chimeric antigen receptor macrophages using a signal switch	95
A two-phase point-of-care diagnostic device for bladder cancer	94
A knockout run for CRISPRed cells	94
Sensing haemodynamics via wearables in sync	90
A deep learning and large language hybrid workflow for omics interpretation	88
Subcutaneous pancreatic islet transplantation without immunosuppression	88
X-ray activated platinum complex induces DNA damage and enhances cancer immunotherapy through abscopal effect	86
mRNA delivery to the endometrium	84
Making MRI increasingly useful	84
A three-dimensional multi-modal foundation model for optical coherence tomography	83
A bilingual speech neuroprosthesis driven by cortical articulatory representations shared between languages	83
Targeting vaccines to dendritic cells by mimicking the processing and presentation of antigens in xenotransplant rejection	82
Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes	81
Nanobody-based bispecific antibody engagers targeting CTLA-4 or PD-L1 for cancer immunotherapy	80
A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	80
Shape-conformal porous frameworks for full coverage of neural organoids and high-resolution electrophysiology	80
Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes	80
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution	80
An off-the-shelf otoacoustic-emission probe for hearing screening via a smartphone	78
Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation	78
1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain	78
Mapping tissue heterogeneity in solid tumours using PET–MRI and machine learning	78

Author Correction: Implanted microelectrode arrays in reinnervated muscles allow separation of neural drives from transferred polyfunctional nerves	78
Deep screening of antibody–antigen affinities	77
Mutation corrections in spinal muscular atrophy	77