OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biomedical Engineering is 77. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	609
Emergency delivery of particulate drugs by active ejection using in vivo wireless devices	422
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence	374
Sensitive detection of SARS-CoV-2 on paper	356
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2	322
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	299
Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	275
Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders	265
A data-efficient strategy for building high-performing medical foundation models	263
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array	233
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria	233
An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains	228
A strain-programmed patch for the healing of diabetic wounds	223
Publisher Correction: Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation	215
Linking the genotypes and phenotypes of cancer cells in heterogenous populations via real-time optical tagging and image analysis	215
Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	214
Streamlining point-of-care assays	213
Ultrasensitive and long-lasting bioluminescence immunoassay for point-of-care viral antigen detection	206
A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide	202
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia	201
FAS-less allogeneic CAR T cells	194
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells	186
Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord	182
A generative model uses healthy and diseased image pairs for pixel-level chest X-ray pathology localization	179
Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats	178

Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries	176
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease	175
Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases	172
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity	168
Fast and sensitive electromechanical sensing	165
Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer	165
Faster detection of somatic structural variants	164
Probing when dCas9 tolerates DNA mismatches	152
Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment	144
Making fitter cells and tissues	144
A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths	143
Offbeat drug-delivery tactics	140
Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor	137
Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions	136
Targeting inflammation with chimeric antigen receptor macrophages using a signal switch	133
Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker	130
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies	128
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver	127
An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity	125
A base editor for the long-term restoration of auditory function in mice with recessive profound deafness	122
Simultaneous visualization of multiple radionuclides in vivo	120
Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody–STING agonist conjugates	119
Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts	118
A knockout run for CRISPRed cells	116
Subcutaneous pancreatic islet transplantation without immunosuppression	112
Sensing haemodynamics via wearables in sync	110
Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation	109
Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes	105
Making MRI increasingly useful	102
Nanobody-based bispecific antibody engagers targeting CTLA-4 or PD-L1 for cancer immunotherapy	102
Targeting vaccines to dendritic cells by mimicking the processing and presentation of antigens in xenotransplant rejection	100
A two-phase point-of-care diagnostic device for bladder cancer	100
Reprogramming of fibroblasts into expandable cardiovascular progenitor cells via small molecules in xeno-free conditions	97
A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	97
1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain	97
A bilingual speech neuroprosthesis driven by cortical articulatory representations shared between languages	96
An off-the-shelf otoacoustic-emission probe for hearing screening via a smartphone	92
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution	90
Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes	89
Mutation corrections in spinal muscular atrophy	84
Deep screening of antibody–antigen affinities	84
Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors	82
Author Correction: Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTENmRNA	82
Mapping tissue heterogeneity in solid tumours using PET–MRI and machine learning	81
Accelerating primer design for amplicon sequencing using large language model-powered agents	80
Eyeing severe diabetes upfront	80
CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers	80
Rapid adaptation of brain–computer interfaces to new neuronal ensembles or participants via generative modelling	80
Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting	79
Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells	79

A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature	79
Straightforward, inexpensive and sensitive	78