OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biomedical Engineering is 78. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	654
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2	464
Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders	416
Brain–heart–eye axis revealed by multi-organ imaging genetics and proteomics	350
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	346
An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains	292
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array	288
Emergency delivery of particulate drugs by active ejection using in vivo wireless devices	279
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence	261
Sensitive detection of SARS-CoV-2 on paper	258
A data-efficient strategy for building high-performing medical foundation models	249
Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	248
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria	244
A strain-programmed patch for the healing of diabetic wounds	238
A generative model uses healthy and diseased image pairs for pixel-level chest X-ray pathology localization	231
Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord	224
FAS-less allogeneic CAR T cells	215
Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer	214
Publisher Correction: Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation	212
Streamlining point-of-care assays	212
Systematic functional screening of switchable aptamer beacon probes	207
Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries	197
Autonomous ultrasound with UltraBot	193
Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	193
A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide	190

Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats	188
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia	183
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease	182
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells	180
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity	170
Linking the genotypes and phenotypes of cancer cells in heterogenous populations via real-time optical tagging and image analysis	163
Ultrasensitive and long-lasting bioluminescence immunoassay for point-of-care viral antigen detection	161
Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases	157
Faster detection of somatic structural variants	155
Probing when dCas9 tolerates DNA mismatches	146
Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis	146
A warm introduction	144
Offbeat drug-delivery tactics	142
Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment	141
Fast and sensitive electromechanical sensing	141
A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths	137
Making fitter cells and tissues	135
Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions	132
A base editor for the long-term restoration of auditory function in mice with recessive profound deafness	131
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver	127
Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody–STING agonist conjugates	124
Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts	122
Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor	122
An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity	115
Targeting inflammation with chimeric antigen receptor macrophages using a signal switch	113
Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker	110
Simultaneous visualization of multiple radionuclides in vivo	110
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies	109
A knockout run for CRISPRed cells	109
A two-phase point-of-care diagnostic device for bladder cancer	107
Sensing haemodynamics via wearables in sync	105
Subcutaneous pancreatic islet transplantation without immunosuppression	104
Making MRI increasingly useful	103
Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes	99
An off-the-shelf otoacoustic-emission probe for hearing screening via a smartphone	98
A bilingual speech neuroprosthesis driven by cortical articulatory representations shared between languages	96
1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain	94
Nanobody-based bispecific antibody engagers targeting CTLA-4 or PD-L1 for cancer immunotherapy	93
Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes	92
Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation	89
A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	89
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution	89
Reprogramming of fibroblasts into expandable cardiovascular progenitor cells via small molecules in xeno-free conditions	88
Targeting vaccines to dendritic cells by mimicking the processing and presentation of antigens in xenotransplant rejection	88
Mapping tissue heterogeneity in solid tumours using PET–MRI and machine learning	87
Mutation corrections in spinal muscular atrophy	86
Deep screening of antibody–antigen affinities	86
Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors	85
Author Correction: Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTENmRNA	84
Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells	83

Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting	83
Profiling protein–protein interactions to predict the efficacy of B-cell-lymphoma-2-homology-3 mimetics for acute myeloid leukaemia	81
Targeted desialylation and cytolysis of tumour cells by fusing a sialidase to a bispecific T-cell engager	78