OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Biomedical Engineering is 77. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	699
Brain–heart–eye axis revealed by multi-organ imaging genetics and proteomics	490
Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders	444
Emergency delivery of particulate drugs by active ejection using in vivo wireless devices	404
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array	372
An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains	314
Sensitive detection of SARS-CoV-2 on paper	309
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	291
A data-efficient strategy for building high-performing medical foundation models	287
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria	286
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence	264
A strain-programmed patch for the healing of diabetic wounds	262
Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	260
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2	257
Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord	248
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity	240
Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases	237
Ultrasensitive and long-lasting bioluminescence immunoassay for point-of-care viral antigen detection	228
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease	221
FAS-less allogeneic CAR T cells	219
Streamlining point-of-care assays	217
Autonomous ultrasound with UltraBot	204
Publisher Correction: Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation	204
Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries	203
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia	201

Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer	201
A generative model uses healthy and diseased image pairs for pixel-level chest X-ray pathology localization	199
Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	193
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells	180
Linking the genotypes and phenotypes of cancer cells in heterogenous populations via real-time optical tagging and image analysis	178
Systematic functional screening of switchable aptamer beacon probes	173
A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide	166
Faster detection of somatic structural variants	165
Offbeat drug-delivery tactics	163
A warm introduction	163
Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment	158
Fast and sensitive electromechanical sensing	153
Making fitter cells and tissues	150
Engineered non-expansive matrix for blood vessel organoid development and ischaemic stroke repair	149
Publisher Correction: Large-scale generation of iNK and CAR-iNK cells from CD34+ haematopoietic stem and progenitor cells for adoptive immunotherapy	143
Probing when dCas9 tolerates DNA mismatches	139
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies	138
A base editor for the long-term restoration of auditory function in mice with recessive profound deafness	133
Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody–STING agonist conjugates	131
A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths	126
Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor	124
Simultaneous visualization of multiple radionuclides in vivo	117
Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions	117
Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker	116
Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts	114
Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis	114
Targeting inflammation with chimeric antigen receptor macrophages using a signal switch	113
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver	112
A knockout run for CRISPRed cells	110
A two-phase point-of-care diagnostic device for bladder cancer	109
Sensing haemodynamics via wearables in sync	106
Making MRI increasingly useful	105
Subcutaneous pancreatic islet transplantation without immunosuppression	105
Reprogramming of fibroblasts into expandable cardiovascular progenitor cells via small molecules in xeno-free conditions	104
An off-the-shelf otoacoustic-emission probe for hearing screening via a smartphone	104
Nanobody-based bispecific antibody engagers targeting CTLA-4 or PD-L1 for cancer immunotherapy	103
Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes	102
A bilingual speech neuroprosthesis driven by cortical articulatory representations shared between languages	99
Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes	98
Targeting vaccines to dendritic cells by mimicking the processing and presentation of antigens in xenotransplant rejection	93
1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain	93
A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples	92
Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation	92
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution	86
Mapping tissue heterogeneity in solid tumours using PET–MRI and machine learning	85
Deep screening of antibody–antigen affinities	82
Mutation corrections in spinal muscular atrophy	82
Author Correction: Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTENmRNA	81
Eyeing severe diabetes upfront	80
Accelerating primer design for amplicon sequencing using large language model-powered agents	79

Engineered thoracic spinal cord organoids for transplantation after spinal cord injury	79
Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors	78
Straightforward, inexpensive and sensitive	77