Nature Biomedical Engineering

Article	Citations
Base editing ablates all protein-coding genes of the mitochondrial genome in mouse cells	905
Arming T cells to infiltrate pancreatic tumours	792
Author Correction: Enhanced control of a brain–computer interface by tetraplegic participants via neural-network-mediated feature extraction	492
A data-efficient strategy for building high-performing medical foundation models	412
Non-viral intron knock-ins for targeted gene integration into human T cells and for T-cell selection	344
3D-printed perfused models of the penis for the study of penile physiology and for restoring erectile function in rabbits and pigs	312
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2	306
Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes	295
Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers	279
Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus	270
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	264
A strain-programmed patch for the healing of diabetic wounds	242
Rational vaccinology maximizes the efficacy of multi-antigen vaccines	240
MRI of transmembrane water efflux in gliomas	237
A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor	223
A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis	222
Generation of synthetic whole-slide image tiles of tumours from RNA-sequencing data via cascaded diffusion models	214
Enhanced control of a brain–computer interface by tetraplegic participants via neural-network-mediated feature extraction	209
Potentiating cancer immunotherapies	197
A window into solid stresses within tumours	195
Glycation-driven matrix crosslinking in cirrhosis	189
The myriad ways to engineer cells	187
Engineering cell-derived extracellular vesicles for gene therapy	187
Enhancement of erythropoietic output by Cas9-mediated insertion of a natural variant in haematopoietic stem and progenitor cells	180
Derivation of prognostic contextual histopathological features from whole-slide images of tumours via graph deep learning	175

Tooling up against mechanobiological orthodoxy	174
Hail the AI journal editor	173
Write accessibly	172
How to appeal well	170
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array	167
Charting targeted courses for vaccination	163
Pathological mechanosensing	163
High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2	162
Sutures for the wireless sensing of deep wounds	161
Author Correction: A low-power stretchable neuromorphic nerve with proprioceptive feedback	160
Publisher Correction: Compression and amplification algorithms in hearing aids impair the selectivity of neural responses to speech	160
Non-invasive monitoring of autophagy	157
Affinity maturation of CRISPR-engineered B cell receptors in vivo	155
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	153
Sealing the heart from the inside out	148
Lasso-grafted designer cytokines	148
Affordable hearing screening	148
Prediction of the cell-type-specific transcription of non-coding RNAs from genome sequences via machine learning	146
Multiplexed transcriptomic profiling of the fate of human CAR T cells in vivo via genetic barcoding with shielded small nucleotides	144
Author Correction: An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity	140
Author Correction: Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans	139
Author Correction: Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system	139
Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand	138
Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier	137
Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors	137
Publisher Correction: Targeting overexpressed antigens in glioblastoma via CAR T cells with computationally designed high-affinity protein binders	137
Author Correction: Prolonged activation of innate immune pathways by a polyvalent STING agonist	131
Retinal detection of kidney disease and diabetes	129
Erythrocyte-mediated systemic immunotherapy	127
Author Correction: Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning	127
Textile-embedded cell-free biosensors	127
Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples	126
Fast volumetric scanning of living tissue	126
Antitumour vaccination via the targeted proteolysis of antigens isolated from tumour lysates	121
A base editor for correcting deafness	121
Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone	119
PEGylated bacteria penetrate mucus and strengthen the gut mucosal barrier	118
Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity	118
Efficient production of non-immunogenic, long circular RNAs for high protein yield	117
Computational design of protein binders that boost the antitumour efficacy of CAR T cells	116
Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering	114
Evolving virus-like particles	114
Detection of signs of disease in external photographs of the eyes via deep learning	112
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence	110
Setting morphogen gradients	110
Characterization of the responses of brain macrophages to focused ultrasound-mediated blood–brain barrier opening	109
Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression	107
Sensitive detection of SARS-CoV-2 on paper	105
A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome	102
Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	102

Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues	102
An engineered live biotherapeutic for the prevention of antibiotic-induced dysbiosis	97
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma	97
An instrument-free, programmable approach for nucleic acid detection	97
Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation	96
A deep-learning model for transforming the style of tissue images from cryosectioned to formalin-fixed and paraffin-embedded	95
Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood–brain barrier in rodents and primates	94
Assessment of visual function in blind mice and monkeys with subretinally implanted nanowire arrays as artificial photoreceptors	93
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma	91
Efficient circular RNA synthesis for potent rolling circle translation	91
Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin	90
Solid stress impairs lymphocyte infiltration into lymph-node metastases	90
Soft and stretchable organic bioelectronics for continuous intraoperative neurophysiological monitoring during microsurgery	90
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance	89
Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression	86
Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans	86
Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound	84
Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells	84
Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains	83
Massively parallel functional photoacoustic computed tomography of the human brain	81
Coordinated AI agents for advancing healthcare	81
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics	80
Profiling of repetitive RNA sequences in the blood plasma of patients with cancer	80
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria	77
Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics	76
Robust and data-efficient generalization of self-supervised machine learning for diagnostic imaging	76
Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours	74
Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy	74
Identification of potent antimicrobial peptides via a machine-learning pipeline that mines the entire space of peptide sequences	73
Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner	73
The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans	73
Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria	72
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure	71
Surgical polarimetric endoscopy for the detection of laryngeal cancer	70
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine	68
Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes	68
A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma	67
Scouring for essential non-coding RNAs	65
Exosome-eluting stents for vascular healing after ischaemic injury	65
Single-cell analysis of ductal differentiation	64
How to make cover letters instructive	64
A highly sensitive and robust one-pot assay for the detection of microRNAs	62
Using extracellular vesicles in blood to diagnose paediatric tuberculosis	61
Towards handy neural prostheses	60
Ever easier health monitoring	59
Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses	58
Converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia identified by an information-theoretic analysis	58
Multimodal evidence suggests the linearity of brain dynamics at the macroscale	57
Streamlining point-of-care assays	57
How we decline manuscripts	57
A biomaterial infused into the bloodstream repairs inflamed tissue	56
Overcoming immune hurdles to implant longevity	56
What’s really new in this work?	55
Lipid nanoparticles for the inhalation of mRNA	55
Moving beyond single-electrode intracortical-microstimulation-evoked tactile perception	55
Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples	55
Enhanced DNA libraries for methylation analysis	54
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity	54
Bacterial couriers as cancer vaccines	53
Author Correction: Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids	53
Chemomechanically antifibrotic stromal cells	53
Scalable and modular wireless-network infrastructure for large-scale behavioural neuroscience	52
Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats	52
Sutureless gastrointestinal anastomoses	51
A one-photon endoscope for simultaneous patterned optogenetic stimulation and calcium imaging in freely behaving mice	51
Massively parallel enrichment of low-frequency alleles enables duplex sequencing at low depth	51
Author Correction: An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis	51
Linking the genotypes and phenotypes of cancer cells in heterogenous populations via real-time optical tagging and image analysis	51
Multi-omics microsampling for the profiling of lifestyle-associated changes in health	51
Bone mineral slows down breast cancer cells	50
Optimization of Cas9 activity through the addition of cytosine extensions to single-guide RNAs	49
Ultrafast longitudinal imaging of haemodynamics via single-shot volumetric photoacoustic tomography with a single-element detector	49
Multifocal fluorescence video-rate imaging of centimetre-wide arbitrarily shaped brain surfaces at micrometric resolution	49
Author Correction: Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager	49
A hydrogel-entrapped live virus immunization	49
Publisher Correction: Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation	48
Blood–wall fluttering instability as a physiomarker of the progression of thoracic aortic aneurysms	48
Multiple-instance learning of somatic mutations for the classification of tumour type and the prediction of microsatellite status	48
Author Correction: High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2	48
Equitable hiring strategies towards a diversified faculty	48

Techniques for supercharging academic writing with generative AI	47
Author Correction: Sensing the DNA-mismatch tolerance of catalytically inactive Cas9 via barcoded DNA nanostructures in solid-state nanopores	47
Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer	46
Designing stable humanized antibodies	46
Acoustic-pressure-driven ultrasonic activation of the mechanosensitive receptor RET and of cell proliferation in colonic tissue	45
FAS-less allogeneic CAR T cells	45
Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases	45
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia	44
Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi	44
Synthetic multimodal data modelling for data imputation	44
Seeing ageing through retinal images	43
Learning spatial cellular motifs predictive of the responses of patients to cancer treatments	43
Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord	43
Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades	42
Control of the antitumour activity and specificity of CAR T cells via organic adapters covalently tethering the CAR to tumour cells	41
Mining for antimicrobial peptides in sequence space	41
Enhancing phage therapy by coating single bacteriophage-infected bacteria with polymer to preserve phage vitality	41
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease	41
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning	40
A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs	40
Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays	40
Transmembrane water-efflux rate measured by magnetic resonance imaging as a biomarker of the expression of aquaporin-4 in gliomas	40
Collagen-binding peptides for the enhanced imaging, lubrication and regeneration of osteoarthritic articular cartilage	40
Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopy	39
Immunization against Zika by entrapping live virus in a subcutaneous self-adjuvanting hydrogel	39
Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroids	39
A miniaturized mesoscope for the large-scale single-neuron-resolved imaging of neuronal activity in freely behaving mice	39
Fast and scalable search of whole-slide images via self-supervised deep learning	39
Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip	38
Robust genome and cell engineering via in vitro and in situ circularized RNAs	38
Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage	38
Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction	38
Adaptive adversarial neural networks for the analysis of lossy and domain-shifted datasets of medical images	37
Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons	36
Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells	36
Addendum: Performance benchmarking of microbubble-localization algorithms for ultrasound localization microscopy	36
PET/MR imaging of inflammation in atherosclerosis	36
Patterned gastrointestinal monolayers with bilateral access as observable models of parasite gut infection	36
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles	35
DNA-based computation for multiple biomarkers	34
Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors	34
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells	33
Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries	32
A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals	32
Deep profiling of gene expression across 18 human cancers	32
Rejuvenation of tumour-specific T cells through bispecific antibodies targeting PD-L1 on dendritic cells	31
Low-cost gastrointestinal manometry via silicone–liquid-metal pressure transducers resembling a quipu	31
Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patterns	31
Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells	31
Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues	30
Performance benchmarking of microbubble-localization algorithms for ultrasound localization microscopy	29
Highly multiplexed rapid DNA detection with single-nucleotide specificity via convective PCR in a portable device	29
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours	29
Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	29
Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis	28
Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism	28
Tomographic detection of photon pairs produced from high-energy X-rays for the monitoring of radiotherapy dosing	28
Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning	28
Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting	28
In situ formation of biomolecular condensates as intracellular drug reservoirs for augmenting chemotherapy	28
A low-power stretchable neuromorphic nerve with proprioceptive feedback	28
Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles	28
Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres	27
Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation	27
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity	26
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy	26
Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy	26
Production of human spinal-cord organoids recapitulating neural-tube morphogenesis	26
Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients	26
Inflammation-induced subcutaneous neovascularization for the long-term survival of encapsulated islets without immunosuppression	26
Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants	26
An injectable and biodegradable zwitterionic gel for extending the longevity and performance of insulin infusion catheters	26
A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback	26
Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds	26
Microfluidic technologies for enhancing the potency, predictability and affordability of adoptive cell therapies	25
How to curb bias in manuscript assessments	25
In-ear integrated sensor array for the continuous monitoring of brain activity and of lactate in sweat	25
Wavering impact-factor trajectories	24
Making fitter cells and tissues	24
A swallowable X-ray dosimeter	24
High-throughput multiplexed serology via the mass-spectrometric analysis of isotopically barcoded beads	24
Prolonging immune responses	23
Molecular probes for in vivo optical imaging of immune cells	23
Five years of S-shaped citation patterns	23
The advent of human-assisted peer review by AI	23
Streamlined detection of SARS-CoV-2 via Cas13	23
Methods, techniques, assays and protocols	23
Stress impacts immunity via the gut	23
Contextual learning is nearly all you need	23
More research will be publicly accessible sooner	23
Nuclear deformation guides chromatin reorganization in cardiac development and disease	23
An antifibrotic therapy for myocardial infarction	22
A learned writing assistant for radiologists	22
A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths	22
An application-based taxonomy for brain–computer interfaces	22