Nature Biomedical Engineering

Article	Citations
Base editing ablates all protein-coding genes of the mitochondrial genome in mouse cells	905
Arming T cells to infiltrate pancreatic tumours	792
Author Correction: Enhanced control of a brain–computer interface by tetraplegic participants via neural-network-mediated feature extraction	492
A data-efficient strategy for building high-performing medical foundation models	412
Non-viral intron knock-ins for targeted gene integration into human T cells and for T-cell selection	344
3D-printed perfused models of the penis for the study of penile physiology and for restoring erectile function in rabbits and pigs	312
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2	306
Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes	295
Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers	279
Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus	270
A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies	264
A strain-programmed patch for the healing of diabetic wounds	242
Rational vaccinology maximizes the efficacy of multi-antigen vaccines	240
MRI of transmembrane water efflux in gliomas	237
A lentiviral vector for the production of T cells with an inducible transgene and a constitutively expressed tumour-targeting receptor	223
A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis	222
Generation of synthetic whole-slide image tiles of tumours from RNA-sequencing data via cascaded diffusion models	214
Enhanced control of a brain–computer interface by tetraplegic participants via neural-network-mediated feature extraction	209
Potentiating cancer immunotherapies	197
A window into solid stresses within tumours	195
Glycation-driven matrix crosslinking in cirrhosis	189
The myriad ways to engineer cells	187
Engineering cell-derived extracellular vesicles for gene therapy	187
Enhancement of erythropoietic output by Cas9-mediated insertion of a natural variant in haematopoietic stem and progenitor cells	180
Derivation of prognostic contextual histopathological features from whole-slide images of tumours via graph deep learning	175

Tooling up against mechanobiological orthodoxy	174
Hail the AI journal editor	173
Write accessibly	172
How to appeal well	170
Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array	167
Pathological mechanosensing	163
Charting targeted courses for vaccination	163
High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2	162
Sutures for the wireless sensing of deep wounds	161
Publisher Correction: Compression and amplification algorithms in hearing aids impair the selectivity of neural responses to speech	160
Author Correction: A low-power stretchable neuromorphic nerve with proprioceptive feedback	160
Non-invasive monitoring of autophagy	157
Affinity maturation of CRISPR-engineered B cell receptors in vivo	155
Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation	153
Affordable hearing screening	148
Sealing the heart from the inside out	148
Lasso-grafted designer cytokines	148
Prediction of the cell-type-specific transcription of non-coding RNAs from genome sequences via machine learning	146
Multiplexed transcriptomic profiling of the fate of human CAR T cells in vivo via genetic barcoding with shielded small nucleotides	144
Author Correction: An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity	140
Author Correction: Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system	139
Author Correction: Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans	139
Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand	138
Publisher Correction: Targeting overexpressed antigens in glioblastoma via CAR T cells with computationally designed high-affinity protein binders	137
Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier	137
Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors	137
Author Correction: Prolonged activation of innate immune pathways by a polyvalent STING agonist	131
Retinal detection of kidney disease and diabetes	129
Textile-embedded cell-free biosensors	127
Erythrocyte-mediated systemic immunotherapy	127
Author Correction: Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning	127
Fast volumetric scanning of living tissue	126
Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples	126
A base editor for correcting deafness	121
Antitumour vaccination via the targeted proteolysis of antigens isolated from tumour lysates	121
Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone	119
Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity	118
PEGylated bacteria penetrate mucus and strengthen the gut mucosal barrier	118
Efficient production of non-immunogenic, long circular RNAs for high protein yield	117
Computational design of protein binders that boost the antitumour efficacy of CAR T cells	116
Evolving virus-like particles	114
Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering	114
Detection of signs of disease in external photographs of the eyes via deep learning	112
Setting morphogen gradients	110
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence	110
Characterization of the responses of brain macrophages to focused ultrasound-mediated blood–brain barrier opening	109
Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression	107
Sensitive detection of SARS-CoV-2 on paper	105
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues	102
A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome	102

Rapid and stain-free quantification of viral plaque via lens-free holography and deep learning	102
An instrument-free, programmable approach for nucleic acid detection	97
An engineered live biotherapeutic for the prevention of antibiotic-induced dysbiosis	97
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma	97
Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation	96
A deep-learning model for transforming the style of tissue images from cryosectioned to formalin-fixed and paraffin-embedded	95
Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood–brain barrier in rodents and primates	94
Assessment of visual function in blind mice and monkeys with subretinally implanted nanowire arrays as artificial photoreceptors	93
Efficient circular RNA synthesis for potent rolling circle translation	91
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma	91
Soft and stretchable organic bioelectronics for continuous intraoperative neurophysiological monitoring during microsurgery	90
Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin	90
Solid stress impairs lymphocyte infiltration into lymph-node metastases	90
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance	89
Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression	86
Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans	86
Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound	84
Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells	84
Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains	83
Massively parallel functional photoacoustic computed tomography of the human brain	81
Coordinated AI agents for advancing healthcare	81
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics	80
Profiling of repetitive RNA sequences in the blood plasma of patients with cancer	80
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria	77
Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics	76
Robust and data-efficient generalization of self-supervised machine learning for diagnostic imaging	76
Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours	74
Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy	74
Identification of potent antimicrobial peptides via a machine-learning pipeline that mines the entire space of peptide sequences	73
Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner	73
The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans	73
Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria	72
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure	71
Surgical polarimetric endoscopy for the detection of laryngeal cancer	70
Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes	68
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine	68
A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma	67
Exosome-eluting stents for vascular healing after ischaemic injury	65
Scouring for essential non-coding RNAs	65
How to make cover letters instructive	64
Single-cell analysis of ductal differentiation	64
A highly sensitive and robust one-pot assay for the detection of microRNAs	62
Using extracellular vesicles in blood to diagnose paediatric tuberculosis	61
Towards handy neural prostheses	60
Ever easier health monitoring	59
Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses	58
Converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia identified by an information-theoretic analysis	58
Multimodal evidence suggests the linearity of brain dynamics at the macroscale	57
Streamlining point-of-care assays	57
How we decline manuscripts	57
A biomaterial infused into the bloodstream repairs inflamed tissue	56
Overcoming immune hurdles to implant longevity	56
What’s really new in this work?	55
Lipid nanoparticles for the inhalation of mRNA	55
Moving beyond single-electrode intracortical-microstimulation-evoked tactile perception	55
Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples	55
Enhanced DNA libraries for methylation analysis	54
Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity	54
Bacterial couriers as cancer vaccines	53
Author Correction: Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids	53
Chemomechanically antifibrotic stromal cells	53
Scalable and modular wireless-network infrastructure for large-scale behavioural neuroscience	52
Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats	52
Multi-omics microsampling for the profiling of lifestyle-associated changes in health	51
Sutureless gastrointestinal anastomoses	51
A one-photon endoscope for simultaneous patterned optogenetic stimulation and calcium imaging in freely behaving mice	51
Massively parallel enrichment of low-frequency alleles enables duplex sequencing at low depth	51
Author Correction: An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis	51
Linking the genotypes and phenotypes of cancer cells in heterogenous populations via real-time optical tagging and image analysis	51
Bone mineral slows down breast cancer cells	50
A hydrogel-entrapped live virus immunization	49
Optimization of Cas9 activity through the addition of cytosine extensions to single-guide RNAs	49
Ultrafast longitudinal imaging of haemodynamics via single-shot volumetric photoacoustic tomography with a single-element detector	49
Multifocal fluorescence video-rate imaging of centimetre-wide arbitrarily shaped brain surfaces at micrometric resolution	49
Author Correction: Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager	49
Equitable hiring strategies towards a diversified faculty	48
Publisher Correction: Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation	48
Blood–wall fluttering instability as a physiomarker of the progression of thoracic aortic aneurysms	48
Multiple-instance learning of somatic mutations for the classification of tumour type and the prediction of microsatellite status	48
Author Correction: High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2	48

Techniques for supercharging academic writing with generative AI	47
Author Correction: Sensing the DNA-mismatch tolerance of catalytically inactive Cas9 via barcoded DNA nanostructures in solid-state nanopores	47
Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer	46
Designing stable humanized antibodies	46
Acoustic-pressure-driven ultrasonic activation of the mechanosensitive receptor RET and of cell proliferation in colonic tissue	45
FAS-less allogeneic CAR T cells	45
Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases	45
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia	44
Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi	44
Synthetic multimodal data modelling for data imputation	44
Seeing ageing through retinal images	43
Learning spatial cellular motifs predictive of the responses of patients to cancer treatments	43
Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord	43