OOIR: Observatory of International Research

Papers

(The median citation count of Oncogenesis is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma	143
Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis	101
Clathrin adapters AP-1 and GGA2 support expression of epidermal growth factor receptor for cell growth	98
CDK4/6 inhibitors and the pRB-E2F1 axis suppress PVR and PD-L1 expression in triple-negative breast cancer	44
Retraction Note: Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress	42
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression	41
A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase	40
USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c	39
NRF2 signaling plays an essential role in cancer progression through the NRF2-GPX2-NOTCH3 axis in head and neck squamous cell carcinoma	37
COX-2/PGE2 upregulation contributes to the chromosome 17p-deleted lymphoma	35
Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species	35
Correction: FAM83B inhibits ovarian cancer cisplatin resistance through inhibiting Wnt pathway	34
Aberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinoma	33
Fibroblasts in metastatic lymph nodes confer cisplatin resistance to ESCC tumor cells via PI16	27
Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients	27
The metastasis suppressor protein NM23-H1 modulates the PI3K-AKT axis through interaction with the p110α catalytic subunit	27
Discovery of neddylation E2s inhibitors with therapeutic activity	26
Tumor-derived miR-130b-3p induces cancer-associated fibroblast activation by targeting SPIN90 in luminal A breast cancer	26
TCF7L1 regulates cytokine response and neuroendocrine differentiation of prostate cancer	26
Correction: Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy	25
USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway	24
Engineered model of t(7;12)(q36;p13) AML recapitulates patient-specific features and gene expression profiles	24
Retraction Note: PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas	23
LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers	22
EDDM3A drives gastric cancer progression by promoting HIF-1α-dependent aerobic glycolysis	22

Estradiol-mediated inhibition of DNMT1 decreases p53 expression to induce M2-macrophage polarization in lung cancer progression	21
CXCL12/CXCR4 axis supports mitochondrial trafficking in tumor myeloma microenvironment	21
PELI1 and EGFR cooperate to promote breast cancer metastasis	21
Androgen receptor variant 7 exacerbates hepatocarcinogenesis in a c-MYC-driven mouse HCC model	20
Emerging role of G9a in cancer stemness and promises as a therapeutic target	19
Activated platelet-derived exosomal LRG1 promotes multiple myeloma cell growth	19
DKK1 as a chemoresistant protein modulates oxaliplatin responses in colorectal cancer	19
A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription	18
Fusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma	18
LUBAC promotes angiogenesis and lung tumorigenesis by ubiquitinating and antagonizing autophagic degradation of HIF1α	18
Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC	18
Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway	18
Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development	17
AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer	17
AIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling	17
High expression of PSMC2 promotes gallbladder cancer through regulation of GNG4 and predicts poor prognosis	17
miR-137–LAPTM4B regulates cytoskeleton organization and cancer metastasis via the RhoA-LIMK-Cofilin pathway in osteosarcoma	17
Non-genetic stratification reveals epigenetic heterogeneity and identifies vulnerabilities of glycolysis addiction in lung adenocarcinoma subtype	17
Cell competition in primary and metastatic colorectal cancer	16
Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer	16
Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling	16
Quercetin induces pannexin 1 expression via an alternative transcript with a translationally active 5′ leader in rhabdomyosarcoma	15
Correction: TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple	15
Correction: Overexpression of SMC4 activates TGFβ/Smad signaling and promotes aggressive phenotype in glioma cells	15
ACTL6A suppresses p21Cip1 tumor suppressor expression to maintain an aggressive mesothelioma cancer cell phenotype	15
Correction: Tumor-derived exosomes induce PD1+ macrophage population in human gastric cancer that promotes disease progression	15
A drug-repositioning screen using splicing-sensitive fluorescent reporters identifies novel modulators of VEGF-A splicing with anti-angiogenic properties	15
Correction to: Migration and invasion is inhibited by silencing ROR1 and ROR2 in chemoresistant ovarian cancer	15
Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity	14
Heparanase modulates the prognosis and development of BRAF V600E-mutant colorectal cancer by regulating AKT/p27Kip1/Cyclin E2 pathway	14
MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma	14
The branched N-glycan of PD-L1 predicts immunotherapy responses in patients with recurrent/metastatic HNSCC	13
Correction: USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c	13
RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway	13
NOTCH1 signaling promotes protein stability of HER3 through the AKT pathway in squamous cell carcinoma of head and neck	13
Correction: Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity	13
Targeted metabolomics detects a putatively diagnostic signature in plasma and dried blood spots from head and neck paraganglioma patients	13
The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells	12
Correction: PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma	12
Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma	12
Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors	12
A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo	12
Correction: Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming	11
Correction: PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma	11
PKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability	11
LIN28B inhibition sensitizes cells to p53-restoring PPI therapy through unleashed translational suppression	11
Depletion of NK6 Homeobox 3 (NKX6.3) causes gastric carcinogenesis through copy number alterations by inducing impairment of DNA replication and repair regulation	11
Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma	11
Retraction Note: A natural food sweetener with anti-pancreatic cancer properties	10
Molecular mechanisms in colitis-associated colorectal cancer	10

Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions	10
Fatty acid transport protein-5 (FATP5) deficiency enhances hepatocellular carcinoma progression and metastasis by reprogramming cellular energy metabolism and regulating the AMPK-mTOR signaling pathwa	10
Retraction Note: A novel microRNA identified in hepatocellular carcinomas is responsive to LEF1 and facilitates proliferation and epithelial-mesenchymal transition via targeting of NFIX	10
SIAH1 reverses chemoresistance in epithelial ovarian cancer via ubiquitination of YBX-1	10
DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance	10
Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma	10
Cell competition and cancer from Drosophila to mammals	10
P4HB maintains Wnt-dependent stemness in glioblastoma stem cells as a precision therapeutic target and serum marker	10
A CRISPR knockout screen reveals new regulators of canonical Wnt signaling	9
Breast cancer in the era of integrating “Omics” approaches	9
Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma	9
ZNF655 accelerates progression of pancreatic cancer by promoting the binding of E2F1 and CDK1	9
UHRF1 overexpression promotes osteosarcoma metastasis through altered exosome production and AMPK/SEMA3E suppression	9
Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway	9
Post-transcriptional screen of cancer amplified genes identifies ERBB2/Her2 signaling as AU-rich mRNA stability-promoting pathway	9
Heterozygotic Brca1 mutation initiates mouse genome instability at embryonic stage	9
Identification of pancreatic cancer-specific protease substrates for protease-dependent targeted delivery	9
Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion	9
Spindle function and Wnt pathway inhibition by PBX1 to suppress tumor progression via downregulating DCDC2 in colorectal cancer	8
Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation	8
Correction: Dihydroartemisinin inhibits prostate cancer via JARID2/miR-7/miR-34a-dependent downregulation of Axl	8
Ubiquitin-specific protease 10 determines colorectal cancer outcome by modulating epidermal growth factor signaling via inositol polyphosphate-4-phosphatase type IIB	8
Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis	8
Overexpression of glycosyltransferase 8 domain containing 2 confers ovarian cancer to CDDP resistance by activating FGFR/PI3K signalling axis	8
Neuron-specific enolase promotes stem cell-like characteristics of small-cell lung cancer by downregulating NBL1 and activating the BMP2/Smad/ID1 pathway	8
Neutrophils and polymorphonuclear myeloid-derived suppressor cells: an emerging battleground in cancer therapy	8
Disruptor of telomeric silencing 1-like promotes ovarian cancer tumor growth by stimulating pro-tumorigenic metabolic pathways and blocking apoptosis	8
Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy	8
The impact of neoadjuvant chemotherapy on the tumor microenvironment in advanced high-grade serous carcinoma	8
Correction: Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation	7
IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming	7
USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer	7
Calreticulin enhances gastric cancer metastasis by dimethylating H3K9 in the E-cadherin promoter region mediating by G9a	7
E2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression	7
The interferon-β/STAT1 axis drives the collective invasion of skin squamous cell carcinoma with sealed intercellular spaces	7
Exosomes and cancer - Diagnostic and prognostic biomarkers and therapeutic vehicle	6
Involvement of the pro-oncogenic enzyme fatty acid synthase in the hallmarks of cancer: a promising target in anti-cancer therapies	6
FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD+ acute myeloid leukemia	6
Targeting fucosyltransferase FUT8 as a prospective therapeutic approach for DLBCL	6
Retinoic acid receptor β modulates mechanosensing and invasion in pancreatic cancer cells via myosin light chain 2	6
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein	6
Correction: FIBP knockdown attenuates growth and enhances chemotherapy in colorectal cancer via regulating GSK3β-related pathways	6
The SWI/SNF ATPase BRG1 facilitates multiple pro-tumorigenic gene expression programs in SMARCB1-deficient cancer cells	6
Combined in vitro/in vivo genome-wide CRISPR screens in triple negative breast cancer identify cancer stemness regulators in paclitaxel resistance	6
CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo	6
The p52-ZER6/G6PD axis alters aerobic glycolysis and promotes tumor progression by activating the pentose phosphate pathway	6