OOIR: Observatory of International Research

Papers

(The H4-Index of Cancer Discovery is 81. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Drafting a Blueprint for European Cancer Research	345
Highlighted research articles	329
Q&A: Philip Greenberg on T Cells, IO's Future	294
AI-Supported Mammography “Safe,” Cuts Workload	281
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	281
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	271
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	235
Probing Clonal Hematopoiesis in Liquid Biopsy	231
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	200
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	191
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	188
Highlighted research articles	188
Trispecifics Improve Immune-Cell Engagement	184
An NK-cell Therapy for CD30+ Lymphomas	177
Lymph Node Metastasis Induces Immune Tolerance and Distant Metastasis	174
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	170
IL7 Genetic Variation Predicts Immune-Related Adverse Events	167
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	161
REFLECTions on Combination Therapies Empowered by Data Sharing	154
Reversing Immune Aging to Improve Immunotherapy Outcomes	151
Disrupting MYC RNA Interactions Promotes Tumor Regression	150
GIST: Molecular Profiling Suggests 2nd Therapy	147
Transposable Element Signatures Define Stages of T-cell Exhaustion	146
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	145
The Dark Side of NK Cells in Cancer Immunotherapy	144

Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	141
Therapy-related mutational signatures in subsequent neoplasms among survivors of childhood cancer	139
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	136
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	136
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	134
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	133
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	129
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	127
Liver Response to Metabolic Stress Drives Cancer-associated Programs	127
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	126
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	125
Longitudinal Plasma Metabolomics Guides Dynamic Risk Assessment and Dietary Modulation for Esophageal Squamous Cell Cancer Chemoimmunotherapy	124
The 3D Revolution in Cancer Discovery	119
Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis	118
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	116
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	114
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	114
Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	113
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	113
Circulating Tumor Cells Predict Response to the DLL3-Targeting Bispecific Antibody Tarlatamab	112
Gut Microbiota Modulation through Akkermansia spp . Supplementation Increases CAR T-cell Potency	112
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	111
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	109
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	109
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	106
New Strategy May Thwart Glioblastoma Resistance	106
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	105
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	104
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	102
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	100
Multicellular Spatial Organization Determines Immunotherapy Response	100
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	99
What's Next for Sotorasib in NSCLC?	98
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	97
In This Issue	95
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	95
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization	95
Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	94
TILs Outperform Ipilimumab in Melanoma	94
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	93
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	92
The Moving Target: Cis -Mutation–Driven Resistance to p53-Y220C Reactivator	91
Bridging the Gap between Diseases of the Stomach and Lower Esophagus	91
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	90
Landmark Pediatric Cancer Legislation Aims to Incentivize Research	90
Myofibroblasts Induce Neuroplasticity to Promote Pancreatic Inflammation and Cancer Progression	90
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity	89
Multimodal AI Model Predicts Breast Cancer Recurrence	89
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	89
Cancer in the Prime of Life: Etiologic Insights and Supportive Oncologic Interventions for the Rising Burden of Young Adult Cancer	89

Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	86
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	86
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy	85
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer	84
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth	84
MCED Testing Enters New Diagnostic Realms	81
The Kinase Module of the Mediator Complex Inhibits CAR T-cell Function	81