OOIR: Observatory of International Research

Papers

(The H4-Index of Cancer Discovery is 81. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Drafting a Blueprint for European Cancer Research	6673
Highlighted research articles	706
Low-Glycemic Diets Restrict Tumor Growth through Altered Lipid Metabolism	364
Mouse Models Provide Insight into Factors Affecting BiTE Efficacy	264
IL7 Genetic Variation Predicts Immune-Related Adverse Events	252
Q&A: Philip Greenberg on T Cells, IO's Future	234
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	229
AI-Supported Mammography “Safe,” Cuts Workload	220
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	216
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	211
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	208
Collagen Receptor Implicated in Immune Exclusion	203
Probing Clonal Hematopoiesis in Liquid Biopsy	191
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	176
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	174
Transposable Element Signatures Define Stages of T-cell Exhaustion	168
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	159
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	158
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	152
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	152
REFLECTions on Combination Therapies Empowered by Data Sharing	150
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	147
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	147
Highlighted research articles	142
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	139

Adjuvant PD-1 Blockade in Resected Melanoma: Is Preventing Recurrence Enough?	136
The 3D Revolution in Cancer Discovery	134
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	131
Trispecifics Improve Immune-Cell Engagement	131
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	130
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	130
Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis	128
The Dark Side of NK Cells in Cancer Immunotherapy	128
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	127
Lymph Node Metastasis Induces Immune Tolerance and Distant Metastasis	127
Gut Microbiota Modulation through Akkermansia spp. Supplementation Increases CAR T-cell Potency	125
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	124
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	121
Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	121
An NK-cell Therapy for CD30+ Lymphomas	120
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	119
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	119
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	115
Structure of the Tumor Stroma Predicts Invasive Breast Cancer Relapse	113
GIST: Molecular Profiling Suggests 2nd Therapy	111
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	111
Exome Sequencing IDs Hidden Disease Variants	111
Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	109
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	109
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	108
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	107
New Strategy May Thwart Glioblastoma Resistance	107
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	106
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	104
Intestinal Microbiome Inhibits CD8+ T Cells via the Calcineurin–NFAT Axis	103
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	103
Multicellular Spatial Organization Determines Immunotherapy Response	101
In This Issue	99
Response to Low Antigen Density Is Improved by HLA-Independent T-cell Receptors	96
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	94
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	93
What's Next for Sotorasib in NSCLC?	93
New Immunotherapy Combinations Enter the Battlefield of Malignant Mesothelioma	92
Bridging the Gap between Diseases of the Stomach and Lower Esophagus	91
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	90
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	90
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	90
Aryl hydrocarbon receptor ligands drive pancreatic cancer initiation and progression through pro-tumorigenic T cell polarization	89
Harnessing Mitochondrial Mutations to ATAC Clonal Evolution in CLL	89
Akk Abundance Alters Survival in Patients with NSCLC on ICIs	88
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	88
Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients	86
Cancer in the Prime of Life: Etiologic Insights and Supportive Oncologic Interventions for the Rising Burden of Young Adult Cancer	86
TILs Outperform Ipilimumab in Melanoma	85
In This Issue	85

Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	84
Rlf–Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer	82
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	82
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth	81
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	81
Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	81