OOIR: Observatory of International Research

Papers

(The H4-Index of Cancer Discovery is 81. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Drafting a Blueprint for European Cancer Research	334
Highlighted research articles	327
Q&A: Philip Greenberg on T Cells, IO's Future	283
AI-Supported Mammography “Safe,” Cuts Workload	277
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	258
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	256
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	232
Probing Clonal Hematopoiesis in Liquid Biopsy	219
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	197
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	193
Highlighted research articles	182
Trispecifics Improve Immune-Cell Engagement	178
An NK-cell Therapy for CD30+ Lymphomas	178
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	178
Lymph Node Metastasis Induces Immune Tolerance and Distant Metastasis	172
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	165
IL7 Genetic Variation Predicts Immune-Related Adverse Events	163
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	161
REFLECTions on Combination Therapies Empowered by Data Sharing	156
Reversing Immune Aging to Improve Immunotherapy Outcomes	149
Disrupting MYC RNA Interactions Promotes Tumor Regression	147
Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	142
GIST: Molecular Profiling Suggests 2nd Therapy	142
Transposable Element Signatures Define Stages of T-cell Exhaustion	141
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	140

The Dark Side of NK Cells in Cancer Immunotherapy	139
The 3D Revolution in Cancer Discovery	139
Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	136
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	132
Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis	128
Liver Response to Metabolic Stress Drives Cancer-associated Programs	128
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	126
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	125
Longitudinal Plasma Metabolomics Guides Dynamic Risk Assessment and Dietary Modulation for Esophageal Squamous Cell Cancer Chemoimmunotherapy	124
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	123
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	122
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	117
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	116
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	115
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	115
Therapy-related mutational signatures in subsequent neoplasms among survivors of childhood cancer	114
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	112
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	111
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	109
Gut Microbiota Modulation through Akkermansia spp . Supplementation Increases CAR T-cell Potency	109
Circulating Tumor Cells Predict Response to the DLL3-Targeting Bispecific Antibody Tarlatamab	109
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	108
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	108
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	107
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	106
New Strategy May Thwart Glioblastoma Resistance	105
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	104
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	102
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	101
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	98
Multicellular Spatial Organization Determines Immunotherapy Response	98
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	98
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	96
What's Next for Sotorasib in NSCLC?	96
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization	94
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	93
TILs Outperform Ipilimumab in Melanoma	92
In This Issue	92
Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients	91
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	91
Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	91
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	90
Myofibroblasts Induce Neuroplasticity to Promote Pancreatic Inflammation and Cancer Progression	89
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity	89
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	88
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	87
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy	87
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	87
Bridging the Gap between Diseases of the Stomach and Lower Esophagus	86
Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	86

Multimodal AI Model Predicts Breast Cancer Recurrence	86
Landmark Pediatric Cancer Legislation Aims to Incentivize Research	84
The Moving Target: Cis -Mutation–Driven Resistance to p53-Y220C Reactivator	84
Cancer in the Prime of Life: Etiologic Insights and Supportive Oncologic Interventions for the Rising Burden of Young Adult Cancer	84
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer	83
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth	83
The Kinase Module of the Mediator Complex Inhibits CAR T-cell Function	81
MCED Testing Enters New Diagnostic Realms	81