OOIR: Observatory of International Research

Papers

(The H4-Index of Cancer Discovery is 85. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
PSMA Expression Is Differentially Regulated across Metastatic Lesions	5494
Cancer-Related Frailty Linked to Cognitive Deficits	981
Tissue-Resident Memory T Cells Underlie Neoadjuvant Immunotherapy Response	608
Structure of the Tumor Stroma Predicts Invasive Breast Cancer Relapse	561
Spatio-Phenotypic Tumor Profiling via Single-Cell 3-D Image Analysis	508
Commensal Bacteria and Fungi Influence Response to Radiation Therapy	399
Erlotinib plus Bevacizumab Is Safe and Effective in EGFR-Mutant NSCLC	352
Drafting a Blueprint for European Cancer Research	350
Leading Oral SERD Shows Prolonged Activity	295
Trastuzumab Deruxtecan Data Impresses at ESMO	246
Collagen Receptor Implicated in Immune Exclusion	227
Genome Doubling Weakens DNA Organization and Supports Tumorigenesis	216
ADCs Inspire $43 Billion Pfizer–Seagen Deal	216
Specific KRAS-Mutant Cancers Are Sensitive to Inhibition of V-type ATPases	206
Adenoviral-Based Cancer Vaccines Promote Anti–PD-1 Treatment Efficacy	192
Early Clones Expand in Richter Transformation of Chronic Lymphocytic Leukemia	186
Cold Exposure Suppresses Tumor Growth through BAT Activation	183
Multicellular Dynamics Associated with Clinical Outcome Were Discovered in PDAC	182
Testing Proton FLASH RT in Bone Mets	180
Noted	177
Urolithin A Induces T Memory Stem Cell Expansion and Antitumor Immunity	174
Sussing Out Adjuvant ICI's Utility in RCC	173
Memory T Cells in Draining Lymph Nodes Potentiate Anti–PD-L1 Therapy	168
GPRC5D CAR T Cells Are Active in BCMA CAR T–Refractory Multiple Myeloma	167
Differential Fungal Mycobiomes Exist between Tumor Types	163

d-2HG Inhibits Effector T Cells by Altering Metabolic Programming	158
Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation	155
Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: TRACERx Renal	147
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	145
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	144
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	142
Highlighted research articles	139
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	138
Simple Hysterectomy Safe for Some Cervical Cancers	135
Senescent Macrophages Promote KRAS-Driven Lung Tumorigenesis	134
A Pan-KRAS Inhibitor Impedes Common KRAS Oncoproteins and Tumor Growth	131
Intratumoral Niches Control CD8+ T-cell Differentiation following ICB	130
Highlighted research articles	126
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	124
Noncanonical Splice Junctions Encode Immunogenic Tumor Neoantigens	121
ZBP1 Mediates Replicative Crisis through Telomere-to-Mitochondria Signaling	120
Scaffolds Improve the Antitumor Activity of Chimeric Antigen Receptors	120
Intermittent Dosing of Milademetan Shows Efficacy and Reduced Toxicity	120
AI-Supported Mammography “Safe,” Cuts Workload	119
CD19 CAR T-cell Clinical Outcome Is Associated with the Gut Microbiome	119
Progression-Free Survival of LM Is Improved by Proton Craniospinal Irradiation	117
Molecular Profiling in Pediatric Cancer Identifies Potential Targeted Therapies	115
Novel Germline Loci Are Associated with Clonal Hematopoiesis Risk	114
To Sleep, Perchance to Metastasize	114
EGFR-Mutant NSCLC: Spotlight on Amivantamab	113
Cilta-cel OK'd for Multiple Myeloma	113
BACE1 Inhibition Stimulates Macrophage Phagocytosis of Glioblastoma Cells	113
Down, but Not Out: A Role for SMARCB1 in Synovial Sarcoma	112
TCR Diversity Underpins Immunotherapy Success	112
Probing Early-Onset Colorectal Cancer	110
F3 Regulates Radiation Therapy–Induced Remodeling and Resistance in Glioblastoma	109
Q&A: Philip Greenberg on T Cells, IO's Future	109
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	108
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	108
Fecal Microbiota Transplantation plus Anti–PD-1 Is Safe in a First-line Setting	106
Clonal Cancer Cells Can Give Rise to Diverse Drug Resistant Populations	106
Pirtobrutinib Shows Efficacy in Pretreated Chronic Lymphocytic Leukemia	105
Assessing Toripalimab in NSCLC	104
Drugs Halt Replication Later than Thought	104
Collagen I Homotrimers Promote PDAC Growth and Impact Immunity	104
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	104
Neutrophil Extracellular Traps Confer Chemoresistance through TGFβ	102
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	98
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	98
Tisagenlecleucel Is Safe and Effective in Relapsed/Refractory Follicular Lymphoma	97
Metabolic Adaptations Alter Metastatic Fitness in Brain-Tropic Breast Cancer	96
Mobocertinib: A Potential Treatment for NSCLC with EGFR Exon 20 Insertions	95
FDA Approves First KRAS Inhibitor: Sotorasib	95
AACR Project GENIE Biopharma Collaborative Releases Colorectal Cancer Dataset	94
War in Ukraine Disrupts Trials, Cancer Care	94

Reforms Urged to Bridge Gender Gaps in Cancer Care	93
ASCL1 and ASCL2 Define Distinct States of Neuroendocrine Prostate Cancer	93
Oral Arsenic Regimen for APL Deemed “Revolutionary”	91
Notch1 Signaling in the White Adipose Tissue Endothelium Promotes Cachexia	89
Probiotic-Guided CAR T cells Promote Antigen-Agnostic Solid Tumor Cytotoxicity	89
CD36 Protects Tumor Cells from Lipotoxicity During Metastasis	88
CAR T-cell Availability for Multiple Myeloma Improving but Still Limited	87
MERCI Predicts Mitochondrial Transfer from T Cells to Tumor Cells	87
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	86
ARPA-H Funds Two Cancer “Manhattan Projects”	85
Tumoral Lactobacillus iners Induces Therapy Resistance Through Metabolic Rewiring	85