Cancer Discovery

Article	Citations
Drafting a Blueprint for European Cancer Research	6673
Highlighted research articles	706
Low-Glycemic Diets Restrict Tumor Growth through Altered Lipid Metabolism	364
Mouse Models Provide Insight into Factors Affecting BiTE Efficacy	264
IL7 Genetic Variation Predicts Immune-Related Adverse Events	252
Q&A: Philip Greenberg on T Cells, IO's Future	234
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	229
AI-Supported Mammography “Safe,” Cuts Workload	220
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	216
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	211
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	208
Collagen Receptor Implicated in Immune Exclusion	203
Probing Clonal Hematopoiesis in Liquid Biopsy	191
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	176
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	174
Transposable Element Signatures Define Stages of T-cell Exhaustion	168
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	159
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	158
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	152
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	152
REFLECTions on Combination Therapies Empowered by Data Sharing	150
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	147
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	147
Highlighted research articles	142
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	139

Adjuvant PD-1 Blockade in Resected Melanoma: Is Preventing Recurrence Enough?	136
The 3D Revolution in Cancer Discovery	134
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	131
Trispecifics Improve Immune-Cell Engagement	131
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	130
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	130
Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis	128
The Dark Side of NK Cells in Cancer Immunotherapy	128
Lymph Node Metastasis Induces Immune Tolerance and Distant Metastasis	127
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	127
Gut Microbiota Modulation through Akkermansia spp. Supplementation Increases CAR T-cell Potency	125
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	124
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	121
Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	121
An NK-cell Therapy for CD30+ Lymphomas	120
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	119
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	119
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	115
Structure of the Tumor Stroma Predicts Invasive Breast Cancer Relapse	113
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	111
Exome Sequencing IDs Hidden Disease Variants	111
GIST: Molecular Profiling Suggests 2nd Therapy	111
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	109
Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	109
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	108
New Strategy May Thwart Glioblastoma Resistance	107
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	107
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	106
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	104
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	103
Intestinal Microbiome Inhibits CD8+ T Cells via the Calcineurin–NFAT Axis	103
Multicellular Spatial Organization Determines Immunotherapy Response	101
In This Issue	99
Response to Low Antigen Density Is Improved by HLA-Independent T-cell Receptors	96
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	94
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	93
What's Next for Sotorasib in NSCLC?	93
New Immunotherapy Combinations Enter the Battlefield of Malignant Mesothelioma	92
Bridging the Gap between Diseases of the Stomach and Lower Esophagus	91
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	90
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	90
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	90
Harnessing Mitochondrial Mutations to ATAC Clonal Evolution in CLL	89
Aryl hydrocarbon receptor ligands drive pancreatic cancer initiation and progression through pro-tumorigenic T cell polarization	89
Akk Abundance Alters Survival in Patients with NSCLC on ICIs	88
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	88
Cancer in the Prime of Life: Etiologic Insights and Supportive Oncologic Interventions for the Rising Burden of Young Adult Cancer	86
Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients	86
In This Issue	85
TILs Outperform Ipilimumab in Melanoma	85

Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	84
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	82
Rlf–Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer	82
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	81
Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	81
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth	81
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity	80
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer	80
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy	80
The Kinase Module of the Mediator Complex Inhibits CAR T-cell Function	79
NRF2: KEAPing Tumors Protected	79
MCED Testing Enters New Diagnostic Realms	77
Resistant KRAS(G12C) Inhibitor Subclones Exhibit Heterogeneous Alterations	76
Ibrutinib with R-CHOP Differentially Affects Genetic Subtypes of DLBCL	76
Blinatumomab Nonresponse Is Associated with Poor CD19-CAR Outcome in B-ALL	74
Study Sniffs Out New Glioma Mechanism	73
A Spatiotemporal Positive Feedback Loop Exists Between TAMs and CD8+ T Cells	73
Chromatin Remodeling Factors Drive Epigenetic Changes Crucial for T-cell Exhaustion	73
Distinct Clonal Patterns Exist between Benign and Malignant Tissue	72
IL6 Blockade Reduces Immunotherapy-Induced Immune-Related Adverse Events	72
Lasker Honors Discovery of Cell Adhesion Molecules	71
ABBV-383 Demonstrates Tolerability and Efficacy in Relapsed/Refractory MM	70
Prenatal Chemotherapy and Its Impact on the Genome of Fetal Hematopoiesis	70
Heritable Defects in Mitotic and Telomere Function Confer Sarcoma Risk	69
Q&A: Robert Vonderheide on Immunotherapy Advances	69
The Hallmarks of Predictive Oncology	69
A Transitional Cell Population Is Enriched in Aggressive Human Medulloblastoma	69
Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2	69
Sex Hormone Signaling Suppresses Ferroptosis via Phospholipid Remodeling	68
Cancer Cells Adapt to SWI/SNF Inhibition through Compensatory EP400 Function	68
Advancing Global Health Equity in Oncology Clinical Trial Access	68
Air Pollution–Lung Cancer Link Identified	68
MDM2-PROTAC versus MDM2 Inhibitors: Beyond p53 Reactivation	68
D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities	68
Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies	67
Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia	67
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors	67
Single-Cell Sequencing Reveals Trajectory of Tumor-Infiltrating Lymphocyte States in Pancreatic Cancer	67
CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma	67
MEDI5752 Suppresses Two Immune Checkpoints	66
High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes	66
EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma	66
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts	66
Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation	65
Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs	64
MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer	62
CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool	62
Surface Expression of NRP1 on Tregs Affects Outcome in Patients with Cancer	61
Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice	61
Structure of the Ligand-Bound HER2–HER3 Dimer Reveals a Dynamic Interface	61
Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML	61
A Deep Learning Model for Cancer Type Prediction Sets a New Standard	60
Glioma Infiltration and Progression Are Driven by Remote Neuronal Activation	60
Silent Mutations Reveal a Novel Treatment for RASQ61 Cancers	60
VCAM1 Mediates Innate Immune Tolerance of Hematopoietic and Leukemic Stem Cells	59
ESCRT Protein Inhibition Enhances CTL-Mediated Cytolysis of Tumor Cells	59
IL4 Signaling in the Bone Marrow Promotes Protumorigenic Myelopoiesis	59
Court Rulings Complicate Decisions for Pregnant Patients	59
Carcinogenic Human Metabolites Are Revealed Using “Metabokiller”	59
Distinct Treatment-Related Immunologic Biomarkers Are Identified in PDAC	58
Glucose Metabolism in TAMs Promotes Metastasis and Drug Resistance	56
The Evolutionary History of Breast Cancer and Related Clones Is Revealed	56
Antitrust Order Aimed at Equalizing MCED Field	56
If You Build It, Patients with Rare Cancers Will Come: A Successful Clinical Trial in Relapsed and Refractory JMML	55
Heterologous Cancer Vaccines plus Checkpoint Inhibitors Show Therapeutic Benefit	55
The APOE–TREM2 Axis Mediates Senescent Neutrophils in Prostate Cancer	55
Sotorasib Tackles KRASG12C-Mutated Pancreatic Cancer	54
Illuminating a Dark Kinase in the Mesenchymal Cancer Cell State	54
Epitope Editing Prevents Off-Tumor Toxicity of CAR T-cell Therapy in AML	54
HeLa Cases Prompt More Thinking on Ethics	54
Peto’s Paradox Is Dead. Long Live Peto’s Paradox	54
Highlighted Research Articles	54
Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression	54
The molecular and functional landscape of resistance to FOLFIRI chemotherapy in metastatic colorectal cancer	53
Methylation Is Best for cfDNA Multicancer Early Detection Tests	53
Bone-Induced HER2 Promotes Secondary Metastasis in HR+/HER2− Breast Cancer	53
Gene-Specific Machine Learning Models to Classify Driver Mutations in Clonal Hematopoiesis	52
The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade	52
Cancer-Associated Fibroblasts Serve as Decoys to Suppress NK Cell Anticancer Cytotoxicity in Breast Cancer	52
CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary	52

Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis	51
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation	51
Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity	51
When Cancer Cells Become the Enablers of an Antitumor Immune Response	51
DietaryLactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy	50
Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors	50
Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer	50
Catalytic Inhibition of KAT6/KAT7 Enhances the Efficacy and Overcomes Primary and Acquired Resistance to Menin Inhibitors in MLL Leukemia	49
Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence	49
Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas	49
SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors	48
A Bacterial-Based Immunotherapy for PDAC	48
Structure of SHOC2–PP1C–RAS Reveals a Mechanism of RAF Activation	48
Specific Anatomic Transcriptomes Drive Oncogenesis in Melanoma	48
A Whole Cancer Cell–Based Vaccine Boosts Cell Killing and Antitumor Immunity	48
ImmunoGen Takeover Caps Year of Record ADC Investments	48
Antitumor Plasma Cells Mature Within Tertiary Lymphoid Structures	47
Tumor-Reactive Antibodies Emerge from Nonbinding and Autoreactive Precursors	47
Atypical EGFR Mutations Show Heterogeneity	47
Molecular Profiles Distinguish Brain Metastases of Diverse Neural Impact	46
Homing In on RNA Fusions in Breast Cancer	46
Kidney Cancer Researcher Tapped as NCI Director	45
Tumor Microenvironment Immune Changes Support Anti-CD19 CAR T-cell Efficacy	44
HER2 Expression Impacts Trastuzumab Deruxtecan Efficacy in Breast Cancer	44
A Base Editing Platform Shows Function of Cancer-Associated Variants	42
Acknowledgment to Reviewers	42
Culture Media Tweak Makes Heartier CARs	42
In This Issue	42
Acknowledgment to Reviewers	41
Precision Cancer Medicine: Large Studies Indicate Steady Progress	40
Lymphocyte Interaction Networks Drive Lung Cancer Immunosurveillance	40
Correction: High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability	40
Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated Pancreatic Cancer in the Clinical and Preclinical Setting	39
An Atlas of Tumor Metabolism Uncovers Gene–Metabolite Interactions	39
Artificial Intelligence and Machine Learning Technologies in Cancer Care: Addressing Disparities, Bias, and Data Diversity	38
Insights and Opportunity Costs in Applying Spatial Biology to Study the Tumor Microenvironment	38
Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium	38
IFNα Potentiates Immune-Checkpoint Blockade by Rewiring Metabolic Cross-talk	37
Highlighted Research Articles	37
Biomolecular Condensation: A New Phase in Cancer Research	37
ATM Inhibition Sensitizes ALT Neuroblastomas to Chemotherapy	37
Clonal GCB Cells Support Angioimmunoblastic T-cell Lymphoma Tumorigenesis	37
Radical Collaboration: Reimagining Cancer Team Science	36
Cancer-Causative Mutations Occurring in Early Embryogenesis	36
DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming	36
Pushing the Boundaries of Liquid Biopsies for Early Precision Intervention	35
Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression	35
Distinct Mutational Processes Influence Germline DNA Mutations	35
Loss of p53 Induces Tolerance to Viral Mimicry as a Mechanism of Immune Evasion in Early Tumorigenesis	35
So Grateful for My X: Sex Chromosomes Drive Differences in Glioblastoma Immunity	35
Single-Cell Tumor–Normal Analysis Proposes Combinatorial CAR Strategies	34
TNF Receptors Choose HSC Fate in SupportingDnmt3a-Mutant Clonal Hematopoiesis	34
Ibrutinib Treatment in Early Stage CLL Prolongs Time to Active Disease	34
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma	34
The Bispecific Antibody Epcoritamab Produces Responses in Lymphoma	34
Colonic Microbiota Promote Antitumor Immunity in Colorectal Cancer	34
Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer	34
Moonshot Redux to Focus on Prevention, Screening	33
Q&A: Ted Laetsch on Tumor-Agnostic Therapies	33
Approved Drugs May Reduce Anthracycline Drug–Related Cardiotoxicity	33
MHC-I Cross-Dressing Supports Antitumor CD8+ T-cell Priming	32
Senescent Cancer Cells Are Vulnerable to Extrinsic Apoptosis Pathway Activation	32
HSCT Chemotherapy Supports Peripheral Macrophage Engraftment of the Brain	32
BTK Inhibitor Options Expand for CLL/SLL	32
Noted	32
A High-Fat Diet Controls MHC Class II on ISCs via the Microbiome	32
On-Target BTK Mutations Promote Resistance to Noncovalent BTK Inhibitors	32
In This Issue	31
Altered tRNA Isoacceptor Abundance Regulates Breast Cancer Metastasis	31
Driver Events of Gastric Cancer Differ According to Subtype and Ancestry	31
Machine Learning Models ID Cancer Drivers	31
High-Endothelial Venules Promote Permissive T-cell Niches after Immunotherapy	31
In This Issue	31
Y Chromosome Loss Drives Bladder Cancer Aggressiveness and Immune Evasion	31
Correction: Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy	30
Nociceptor Neurons Affect Immunosurveillance and Tumor Growth	30
Gut Microbiota Regulate PD-L2 Expression and Immunotherapy Response	30
Disruption of KAT8–IRF1 Condensate Formation Reduces PD-L1 Expression	30
Primary, Metastatic Tumors Vary Genomically by Cancer Type	30
Correction: Highlights of FDA Oncology Approvals in 2023: Bispecific T-cell Engagers, Pediatric Indications, and Inclusive Drug Development	30
PHGDH Inhibition Overcomes Glioblastoma Resistance to T-cell Therapy	30
Intrinsically Disordered Regions Control cBAF Condensation and Interactions	30
Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer	29
Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-free DNA Methylation	29
Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling	29
Receptor-interacting Protein Kinase 2 Is an Immunotherapy Target in Pancreatic Cancer	29
Correction: Animal Alternatives OK'd by New Law	29
Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts	29
Dangerous Liaisons betweenTet2Mutation, Inflammatory Monocytes, and Leukemogenesis	28
Artificial Intelligence Identifies Novel Disease Pathways	28
Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma	27
Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer	27
Immunogenicity and Efficacy of Personalized Adjuvant mRNA Cancer Vaccines	27
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas	27
HPV42, a “Low-Risk” Type, and Digital Papillary Adenocarcinoma	27