Cancer Discovery

Article	Citations
Drafting a Blueprint for European Cancer Research	7268
Highlighted research articles	779
Low-Glycemic Diets Restrict Tumor Growth through Altered Lipid Metabolism	393
Q&A: Philip Greenberg on T Cells, IO's Future	290
HLA-E:CD94–NKG2A Mediates Circulating Tumor Cell Immune Evasion	262
AI-Supported Mammography “Safe,” Cuts Workload	260
Mutation-Driven Alveolar Cell Reprogramming Dictates Lung Cancer Progression	251
Succinyl-CoA and Cobalamin Are Biomarkers That Improve Anal Cancer Screening	245
Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy	236
Probing Clonal Hematopoiesis in Liquid Biopsy	230
Shattered Chromosomes Undergo Mitotic Tethering during Chromothripsis	208
PARADIGM Identifies Associations between Drugs, the Microbiome, and Mortality	192
Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells	189
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC	188
Correction: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer	180
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	178
Highlighted research articles	170
An NK-cell Therapy for CD30+ Lymphomas	167
Proteostasis Network Modulation Promotes Resistance to KRAS Inhibitors	167
Lymph Node Metastasis Induces Immune Tolerance and Distant Metastasis	152
RAS Drives Malignancy through Altered Stem Cell/Microenvironment Cross-talk	148
IL7 Genetic Variation Predicts Immune-Related Adverse Events	145
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer	145
Trispecifics Improve Immune-Cell Engagement	145
GIST: Molecular Profiling Suggests 2nd Therapy	144

Exome Sequencing IDs Hidden Disease Variants	142
Dendritic Cell Circadian Rhythm Governs the Antitumor Immune Response	139
Collagen Receptor Implicated in Immune Exclusion	139
Structure of the Tumor Stroma Predicts Invasive Breast Cancer Relapse	139
Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis	137
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway	136
A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome	135
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers	133
Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma	132
Adjuvant PD-1 Blockade in Resected Melanoma: Is Preventing Recurrence Enough?	128
REFLECTions on Combination Therapies Empowered by Data Sharing	127
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta	122
Gut Microbiota Modulation through Akkermansia spp . Supplementation Increases CAR T-cell Potency	120
Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response	119
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma	118
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors	118
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression	117
Transposable Element Signatures Define Stages of T-cell Exhaustion	115
A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy	114
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression	113
The Dark Side of NK Cells in Cancer Immunotherapy	112
CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma	110
The 3D Revolution in Cancer Discovery	109
Presurgery Plus Postsurgery Immunotherapy Ups Survival in NSCLC	108
New Strategy May Thwart Glioblastoma Resistance	105
FMRP Depletion Reprograms an Immunosuppressive Microenvironment	103
Tumor-Derived Extracellular Vesicles and Particles Inhibit Liver Function	102
The Proteasome Regulator PSME4 Modulates Antitumor Immunity	102
Chronic Inflammation Drives TP53-Mutant Leukemic Evolution	101
In This Issue	101
Multicellular Spatial Organization Determines Immunotherapy Response	101
Response to Low Antigen Density Is Improved by HLA-Independent T-cell Receptors	100
What's Next for Sotorasib in NSCLC?	99
Revumenib Is Safe and Efficacious, but MEN1 Mutations Mediate Resistance	99
Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells	96
Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons	96
Akk Abundance Alters Survival in Patients with NSCLC on ICIs	95
Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations	95
In This Issue	95
Cancer in the Prime of Life: Etiologic Insights and Supportive Oncologic Interventions for the Rising Burden of Young Adult Cancer	95
TILs Outperform Ipilimumab in Melanoma	94
Hyperactivation of Oncogenic Pathways Hinders Cancer Cell Survival	93
Lymph Node–Specific IFNγ Levels Affect CD8+ T-cell Priming against Tumors	92
Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53	91
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy	91
Bridging the Gap between Diseases of the Stomach and Lower Esophagus	90
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology	90
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization	89
Intestinal Microbiome Inhibits CD8+ T Cells via the Calcineurin–NFAT Axis	89
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells	86

AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer	85
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth	84
Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer	83
NRF2: KEAPing Tumors Protected	82
The Kinase Module of the Mediator Complex Inhibits CAR T-cell Function	82
Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients	82
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity	82
Blinatumomab Nonresponse Is Associated with Poor CD19-CAR Outcome in B-ALL	81
MCED Testing Enters New Diagnostic Realms	81
Ibrutinib with R-CHOP Differentially Affects Genetic Subtypes of DLBCL	81
Resistant KRAS(G12C) Inhibitor Subclones Exhibit Heterogeneous Alterations	81
Study Sniffs Out New Glioma Mechanism	80
A Spatiotemporal Positive Feedback Loop Exists Between TAMs and CD8+ T Cells	79
Chromatin Remodeling Factors Drive Epigenetic Changes Crucial for T-cell Exhaustion	79
Lasker Honors Discovery of Cell Adhesion Molecules	78
IL6 Blockade Reduces Immunotherapy-Induced Immune-Related Adverse Events	78
Distinct Clonal Patterns Exist between Benign and Malignant Tissue	78
A Transitional Cell Population Is Enriched in Aggressive Human Medulloblastoma	77
Prenatal Chemotherapy and Its Impact on the Genome of Fetal Hematopoiesis	77
ABBV-383 Demonstrates Tolerability and Efficacy in Relapsed/Refractory MM	77
Q&A: Robert Vonderheide on Immunotherapy Advances	76
Heritable Defects in Mitotic and Telomere Function Confer Sarcoma Risk	76
Highlighted Research Articles	75
Cancer Cells Adapt to SWI/SNF Inhibition through Compensatory EP400 Function	75
Air Pollution–Lung Cancer Link Identified	75
Advancing Global Health Equity in Oncology Clinical Trial Access	74
Epigenetic Regulation of Chromosomal Instability by EZH2 Methyltransferase	74
A Plastic EMP1 + to LGR5 + Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metas	73
Sex Hormone Signaling Suppresses Ferroptosis via Phospholipid Remodeling	73
Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation	73
Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs	73
Single-Cell Sequencing Reveals Trajectory of Tumor-Infiltrating Lymphocyte States in Pancreatic Cancer	72
CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma	72
EP300 Selectively Controls the Enhancer Landscape of MYCN -Amplified Neuroblastoma	71
D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities	70
Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML	70
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibit	70
MDM2-PROTAC versus MDM2 Inhibitors: Beyond p53 Reactivation	68
The Hallmarks of Predictive Oncology	68
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts	66
Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies	65
MEDI5752 Suppresses Two Immune Checkpoints	65
Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice	65
MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP -Deleted Cancer	65
Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia	65
High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes	64
Structure of the Ligand-Bound HER2–HER3 Dimer Reveals a Dynamic Interface	63
CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool	63
Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2	63
Surface Expression of NRP1 on Tregs Affects Outcome in Patients with Cancer	63
Glioma Infiltration and Progression Are Driven by Remote Neuronal Activation	62
Silent Mutations Reveal a Novel Treatment for RASQ61 Cancers	62
ESCRT Protein Inhibition Enhances CTL-Mediated Cytolysis of Tumor Cells	62
Distinct Treatment-Related Immunologic Biomarkers Are Identified in PDAC	61
VCAM1 Mediates Innate Immune Tolerance of Hematopoietic and Leukemic Stem Cells	61
Carcinogenic Human Metabolites Are Revealed Using “Metabokiller”	61
Court Rulings Complicate Decisions for Pregnant Patients	61
IL4 Signaling in the Bone Marrow Promotes Protumorigenic Myelopoiesis	61
Antitrust Order Aimed at Equalizing MCED Field	60
The Evolutionary History of Breast Cancer and Related Clones Is Revealed	59
Heterologous Cancer Vaccines plus Checkpoint Inhibitors Show Therapeutic Benefit	58
The APOE–TREM2 Axis Mediates Senescent Neutrophils in Prostate Cancer	58
Glucose Metabolism in TAMs Promotes Metastasis and Drug Resistance	58
Epitope Editing Prevents Off-Tumor Toxicity of CAR T-cell Therapy in AML	57
Highlighted Research Articles	57
Illuminating a Dark Kinase in the Mesenchymal Cancer Cell State	57
Peto’s Paradox Is Dead. Long Live Peto’s Paradox	57
Methylation Is Best for cfDNA Multicancer Early Detection Tests	56
HeLa Cases Prompt More Thinking on Ethics	56
The Bitter Aftertaste of Artificial Sweeteners in Cancer Immunotherapy	55
A Deep Learning Model for Cancer Type Prediction Sets a New Standard	55
Sotorasib Tackles KRASG12C-Mutated Pancreatic Cancer	55
If You Build It, Patients with Rare Cancers Will Come: A Successful Clinical Trial in Relapsed and Refractory JMML	55
Gene-Specific Machine Learning Models to Classify Driver Mutations in Clonal Hematopoiesis	55
The UBA1–STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade	54
Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression	54
Catalytic Inhibition of KAT6/KAT7 Enhances the Efficacy and Overcomes Primary and Acquired Resistance to Menin Inhibitors in MLL Leukemia	54
Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors	53
The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer	52
When Cancer Cells Become the Enablers of an Antitumor Immune Response	52

Clonal Hematopoiesis Enhances Immunotherapy Response in Solid Tumors	51
Tumor-infiltrating Bacteria Induce Quiescence and Therapy Resistance	50
Cancer-Associated Fibroblasts Serve as Decoys to Suppress NK Cell Anticancer Cytotoxicity in Breast Cancer	49
Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence	49
SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors	49
Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis	48
Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity	48
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation	48
A High-Fiber Plant-Based Diet in Myeloma Precursor Disorders – Results from the NUTRIVENTION Clinical Trial and Preclinical Vk*MYC Model	48
Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas	47
Bone-Induced HER2 Promotes Secondary Metastasis in HR+/HER2− Breast Cancer	47
CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary	47
Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer	46
Dietary Lactobacillus -Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy	46
ImmunoGen Takeover Caps Year of Record ADC Investments	45
A Whole Cancer Cell–Based Vaccine Boosts Cell Killing and Antitumor Immunity	45
Structure of SHOC2–PP1C–RAS Reveals a Mechanism of RAF Activation	44
Homing In on RNA Fusions in Breast Cancer	44
Specific Anatomic Transcriptomes Drive Oncogenesis in Melanoma	44
Molecular Profiles Distinguish Brain Metastases of Diverse Neural Impact	44
Antitumor Plasma Cells Mature Within Tertiary Lymphoid Structures	44
A Bacterial-Based Immunotherapy for PDAC	44
Tumor-Reactive Antibodies Emerge from Nonbinding and Autoreactive Precursors	44
Kidney Cancer Researcher Tapped as NCI Director	43
HER2 Expression Impacts Trastuzumab Deruxtecan Efficacy in Breast Cancer	42
Tumor Microenvironment Immune Changes Support Anti-CD19 CAR T-cell Efficacy	42
A Base Editing Platform Shows Function of Cancer-Associated Variants	42
Culture Media Tweak Makes Heartier CARs	41
In This Issue	41
Acknowledgment to Reviewers	41
IFNα Potentiates Immune-Checkpoint Blockade by Rewiring Metabolic Cross-talk	40
Insights and Opportunity Costs in Applying Spatial Biology to Study the Tumor Microenvironment	40
Acknowledgment to Reviewers	40
Highlighted Research Articles	40
An Atlas of Tumor Metabolism Uncovers Gene–Metabolite Interactions	40
Clonal GCB Cells Support Angioimmunoblastic T-cell Lymphoma Tumorigenesis	40
Lymphocyte Interaction Networks Drive Lung Cancer Immunosurveillance	40
Biomolecular Condensation: A New Phase in Cancer Research	39
Artificial Intelligence and Machine Learning Technologies in Cancer Care: Addressing Disparities, Bias, and Data Diversity	38
So Grateful for My X: Sex Chromosomes Drive Differences in Glioblastoma Immunity	38
Loss of p53 Induces Tolerance to Viral Mimicry as a Mechanism of Immune Evasion in Early Tumorigenesis	38
Radical Collaboration: Reimagining Cancer Team Science	38
TNF Receptors Choose HSC Fate in Supporting Dnmt3a -Mutant Clonal Hematopoiesis	38
Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium	37
Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA –Associated Pancreatic Cancer in the Clinical and Preclinical Setting	37
Pushing the Boundaries of Liquid Biopsies for Early Precision Intervention	37
Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression	37
Colonic Microbiota Promote Antitumor Immunity in Colorectal Cancer	36
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma	36
Moonshot Redux to Focus on Prevention, Screening	36
Single-Cell Tumor–Normal Analysis Proposes Combinatorial CAR Strategies	36
DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming	36
Ibrutinib Treatment in Early Stage CLL Prolongs Time to Active Disease	36
Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer	36
Noted	35
On-Target BTK Mutations Promote Resistance to Noncovalent BTK Inhibitors	35
HSCT Chemotherapy Supports Peripheral Macrophage Engraftment of the Brain	35
MHC-I Cross-Dressing Supports Antitumor CD8+ T-cell Priming	35
Y Chromosome Loss Drives Bladder Cancer Aggressiveness and Immune Evasion	34
BTK Inhibitor Options Expand for CLL/SLL	34
Driver Events of Gastric Cancer Differ According to Subtype and Ancestry	34
Altered tRNA Isoacceptor Abundance Regulates Breast Cancer Metastasis	34
Senescent Cancer Cells Are Vulnerable to Extrinsic Apoptosis Pathway Activation	34
In This Issue	34
High-Endothelial Venules Promote Permissive T-cell Niches after Immunotherapy	34
Correction: Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy	33
Nociceptor Neurons Affect Immunosurveillance and Tumor Growth	33
Correction: Highlights of FDA Oncology Approvals in 2023: Bispecific T-cell Engagers, Pediatric Indications, and Inclusive Drug Development	33
Tackling Cancer through Global Team Science	32
Intrinsically Disordered Regions Control cBAF Condensation and Interactions	32
PHGDH Inhibition Overcomes Glioblastoma Resistance to T-cell Therapy	32
Artificial Intelligence Identifies Novel Disease Pathways	32
Primary, Metastatic Tumors Vary Genomically by Cancer Type	32
Disruption of KAT8–IRF1 Condensate Formation Reduces PD-L1 Expression	32
Correction: Animal Alternatives OK'd by New Law	32
Gut Microbiota Regulate PD-L2 Expression and Immunotherapy Response	32
Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants	31
Dual Immunotherapy Makes Strides against HCC	31
Micronuclei and Cancer	30
Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer	30
HPV42, a “Low-Risk” Type, and Digital Papillary Adenocarcinoma	30
Cell States in Cancer: Drivers, Passengers, and Trailers	30
The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine	30
Dangerous Liaisons between Tet2 Mutation, Inflammatory Monocytes, and Leukemogenesis	30
Germline–Somatic Liaison Dictates Cancer Subtypes via de novo Steroid Biosynthesis	30
Receptor-interacting Protein Kinase 2 Is an Immunotherapy Target in Pancreatic Cancer	30
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas	29
The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer	29
Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-free DNA Methylation	29
Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts	29
Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling	29
Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer	29
Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection	29
Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma	29
Tissue-Resident Memory-like Lymphocytes Demonstrate Effector Activity in Ovarian Cancer	28