OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Therapy-Nucleic Acids is 46. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Effective intravitreal gene delivery to retinal pigment epithelium with hyaluronic acid nanospheres	142
Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation	94
Cas-CLOVER is a novel high-fidelity nuclease for safe and robust generation of TSCM-enriched allogeneic CAR-T cells	84
Highly efficient A-to-G base editing by ABE8.17 in rabbits	81
Retraction Notice to: Hypoxic tumor-derived exosomal circular RNA SETDB1 promotes invasive growth and EMT via the miR-7/Sp1 axis in lung adenocarcinoma	80
SPRINGing forward: Advancing RNA editing efficiency and precision with engineered ADAR2	78
Durable HTT silencing using non-evolved dCas9 epigenome editors in patient-derived cells	78
An oversized AAV8 vector to deliver CPS1	77
Modulation of miR-29 influences myocardial compliance likely through coordinated regulation of calcium handling and extracellular matrix	76
Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling	76
Alleviation of ischemia-reperfusion induced renal injury by chemically modified SOD2 mRNA delivered via lipid nanoparticles	74
Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer’s disease	73
Unlocking RNA mysteries: Predicting subcellular localizations with AI	72
Mitochondrial double-stranded RNAs as a pivotal mediator in the pathogenesis of Sjӧgren’s syndrome	70
RETRACTED: HOXA5-miR-574-5p axis promotes adipogenesis and alleviates insulin resistance	64
LinQURE: A novel AAV gene silencing platform that supports multi-transcript targeting for complex disorders	63
AAV-vectored base editor trans-splicing delivers dystrophin repair	63
Efficient transfected liposomes co-loaded with pNrf2 and pirfenidone improves safe delivery for enhanced pulmonary fibrosis reversion	63
Emerging roles of circRNAs in the pathological process of myocardial infarction	62
Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells	62
Single-cell transcriptome profiling implicates the psychological stress-induced disruption of spermatogenesis	61
A potent GalNAc-siRNA drug, RBD1016, leads to sustained HBsAg reduction and seroconversion in mouse models of HBV infection	61
Enhanced molecular dynamic simulation studies unravel long-range effects caused by sequence variations and partner binding in RNA aptamers	60
A bimolecular modification strategy for developing long-lasting bone anabolic aptamer	59
Ferroptosis as a therapeutic target in glioblastoma: Mechanisms and emerging strategies	59

Inefficacy of anti-VEGF therapy reflected in VEGF-mediated photoreceptor degeneration	56
Single-swap editing for the correction of common Duchenne muscular dystrophy mutations	55
Implications of circular transcripts in DM1 pathomechanism	54
Progress and prospect of minicircle as a minimized non-viral DNA vector in gene therapy and regenerative medicine	53
Forced enhancer-promoter rewiring to alter gene expression in animal models	51
Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1	51
Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli	49
Extracellular viral microRNAs as biomarkers of virus infection in human cells	49
Insights into the regulatory role of epigenetics in moyamoya disease: Current advances and future prospectives	49
All roads lead to cure: Diversity of oligonucleotides in DM1 therapy	49
Novel insights into the interaction between N6-methyladenosine modification and circular RNA	49
MicroRNA-466 and microRNA-200 increase endothelial permeability in hyperglycemia by targeting Claudin-5	49
CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA	49
A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition	48
DNA-PKcs inhibition improves sequential gene insertion of the full-length CFTR cDNA in airway stem cells	47
miR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways	47
Antitumor effects of chemically modified miR-143 lipoplexes in a mouse model of pelvic colorectal cancer via myristoylated alanine-rich C kinase substrate downregulation	47
Engineering B cells with customized therapeutic responses using a synthetic circuit	47
PPFIA1-targeting miR-181a mimic and saRNA overcome imatinib resistance in BCR-ABL1-independent chronic myeloid leukemia by suppressing leukemia stem cell regeneration	46
Discovery of peptides for ligand-mediated delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia	46
circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway	46
Intermittent lipid nanoparticle mRNA administration prevents cortical dysmyelination associated with arginase deficiency	46