OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Therapy-Nucleic Acids is 45. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Effective intravitreal gene delivery to retinal pigment epithelium with hyaluronic acid nanospheres	139
Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation	94
Cas-CLOVER is a novel high-fidelity nuclease for safe and robust generation of TSCM-enriched allogeneic CAR-T cells	81
Highly efficient A-to-G base editing by ABE8.17 in rabbits	80
MicroRNA-466 and microRNA-200 increase endothelial permeability in hyperglycemia by targeting Claudin-5	77
Retraction Notice to: Hypoxic tumor-derived exosomal circular RNA SETDB1 promotes invasive growth and EMT via the miR-7/Sp1 axis in lung adenocarcinoma	76
Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1	76
All roads lead to cure: Diversity of oligonucleotides in DM1 therapy	75
Mitochondrial double-stranded RNAs as a pivotal mediator in the pathogenesis of Sjӧgren’s syndrome	75
RETRACTED: HOXA5-miR-574-5p axis promotes adipogenesis and alleviates insulin resistance	73
Single-swap editing for the correction of common Duchenne muscular dystrophy mutations	73
Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer’s disease	72
Unlocking RNA mysteries: Predicting subcellular localizations with AI	70
Alleviation of ischemia-reperfusion induced renal injury by chemically modified SOD2 mRNA delivered via lipid nanoparticles	68
Durable HTT silencing using non-evolved dCas9 epigenome editors in patient-derived cells	62
Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling	62
Single-cell transcriptome profiling implicates the psychological stress-induced disruption of spermatogenesis	61
SPRINGing forward: Advancing RNA editing efficiency and precision with engineered ADAR2	61
An oversized AAV8 vector to deliver CPS1	60
Inefficacy of anti-VEGF therapy reflected in VEGF-mediated photoreceptor degeneration	60
Modulation of miR-29 influences myocardial compliance likely through coordinated regulation of calcium handling and extracellular matrix	59
AAV-vectored base editor trans-splicing delivers dystrophin repair	58
LinQURE: A novel AAV gene silencing platform that supports multi-transcript targeting for complex disorders	57
Novel insights into the interaction between N6-methyladenosine modification and circular RNA	57
Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells	57

Forced enhancer-promoter rewiring to alter gene expression in animal models	56
Enhanced molecular dynamic simulation studies unravel long-range effects caused by sequence variations and partner binding in RNA aptamers	52
Efficient transfected liposomes co-loaded with pNrf2 and pirfenidone improves safe delivery for enhanced pulmonary fibrosis reversion	52
Emerging roles of circRNAs in the pathological process of myocardial infarction	50
Engineering B cells with customized therapeutic responses using a synthetic circuit	49
Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli	49
A bimolecular modification strategy for developing long-lasting bone anabolic aptamer	49
Ferroptosis as a Therapeutic Target in Glioblastoma: Mechanisms and Emerging Strategies	49
Insights into the regulatory role of epigenetics in moyamoya disease: Current advances and future prospectives	49
Extracellular viral microRNAs as biomarkers of virus infection in human cells	48
CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA	48
A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition	48
Antitumor effects of chemically modified miR-143 lipoplexes in a mouse model of pelvic colorectal cancer via myristoylated alanine-rich C kinase substrate downregulation	47
Precise detection of CRISPR-Cas9 editing in hair cells in the treatment of autosomal dominant hearing loss	47
DNA-PKcs inhibition improves sequential gene insertion of the full-length CFTR cDNA in airway stem cells	46
HnRNP-L-regulated circCSPP1/miR-520h/EGR1 axis modulates autophagy and promotes progression in prostate cancer	45
Topical application of a CCL22-binding aptamer suppresses contact allergy	45
circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway	45
Towards SINEUP-based therapeutics: Design of an in vitro synthesized SINEUP RNA	45
RETRACTED: LncRNA PVT1 promotes tumorigenesis of glioblastoma by recruiting COPS5 to deubiquitinate and stabilize TRIM24	45