Drug Delivery and Translational Research

Article	Citations
Intranasal drug delivery: opportunities and toxicologic challenges during drug development	202
Enhancement strategies for transdermal drug delivery systems: current trends and applications	159
Nanotechnology-based antiviral therapeutics	155
Corticosteroids in ophthalmology: drug delivery innovations, pharmacology, clinical applications, and future perspectives	105
Current hurdles to the translation of nanomedicines from bench to the clinic	96
Current approaches in lipid-based nanocarriers for oral drug delivery	85
Ultrasound-responsive polymer-based drug delivery systems	76
Clinical approval of nanotechnology-based SARS-CoV-2 mRNA vaccines: impact on translational nanomedicine	71
Therapy of infected wounds: overcoming clinical challenges by advanced drug delivery systems	62
Polymeric micelles and cancer therapy: an ingenious multimodal tumor-targeted drug delivery system	60
Influencing factors and drug application of iontophoresis in transdermal drug delivery: an overview of recent progress	59
Exosomal targeting and its potential clinical application	59
Emerging era of “somes”: polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy	58
Cyclodextrin-based delivery systems for in vivo-tested anticancer therapies	49
Clinical translation of gold nanoparticles	48
An overview of chitosan and its application in infectious diseases	47
Inhalable solid lipid nanoparticles for intracellular tuberculosis infection therapy: macrophage-targeting and pH-sensitive properties	47
Formulation and evaluation of cubosomes containing colchicine for transdermal delivery	46
PEI fluorination reduces toxicity and promotes liver-targeted siRNA delivery	46
Perspectives of characterization and bioconjugation of gold nanoparticles and their application in lateral flow immunosensing	45
Robotics, microfluidics, nanotechnology and AI in the synthesis and evaluation of liposomes and polymeric drug delivery systems	44
Anacardic acid encapsulated solid lipid nanoparticles for Staphylococcus aureus biofilm therapy: chitosan and DNase coating improves antimicrobial activity	43
Development of vaccine formulations: past, present, and future	43
Formulation development of linagliptin solid lipid nanoparticles for oral bioavailability enhancement: role of P-gp inhibition	42
Recent advances in porous microneedles: materials, fabrication, and transdermal applications	40

Enhancement of skin permeability with thermal ablation techniques: concept to commercial products	40
A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects	38
Rifampicin loaded in alginate/chitosan nanoparticles as a promising pulmonary carrier against Staphylococcus aureus	38
Intranasal drug delivery for treatment of Alzheimer’s disease	37
QbD aided development of ibrutinib-loaded nanostructured lipid carriers aimed for lymphatic targeting: evaluation using chylomicron flow blocking approach	36
Exploring the role of mesoporous silica nanoparticle in the development of novel drug delivery systems	35
Nanoparticle-mediated pulmonary drug delivery: state of the art towards efficient treatment of recalcitrant respiratory tract bacterial infections	35
Levofloxacin nanoemulsion gel has a powerful healing effect on infected wound in streptozotocin-induced diabetic rats	34
Topical delivery of 5-fluorouracil-loaded carboxymethyl chitosan nanoparticles using microneedles for keloid treatment	34
In vitro and in vivo evaluation of cubosomal nanoparticles as an ocular delivery system for fluconazole in treatment of keratomycosis	34
Phospholipid complex-loaded self-assembled phytosomal soft nanoparticles: evidence of enhanced solubility, dissolution rate, ex vivo permeability, oral bioavailability, and antioxidant potential of ma	34
Recent advances on microneedle arrays-mediated technology in cancer diagnosis and therapy	33
Nanotechnology-based approaches applied to nutraceuticals	33
From micro to nano: evolution and impact of drug delivery in treating disease	33
Drug delivery device for the inner ear: ultra-sharp fully metallic microneedles	33
Cell membrane-coated nanoparticles: a novel multifunctional biomimetic drug delivery system	33
Afatinib-loaded inhalable PLGA nanoparticles for localized therapy of non-small cell lung cancer (NSCLC)—development and in-vitro efficacy	33
Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical delivery: QbD-driven design, optimization, and in vitro and ex vivo evaluations	32
Novel nanoemulsion gel containing triple natural bio-actives combination of curcumin, thymoquinone, and resveratrol improves psoriasis therapy: in vitro and in vivo studies	31
Improving dexamethasone drug loading and efficacy in treating arthritis through a lipophilic prodrug entrapped into PLGA-PEG nanoparticles	30
Nose-to-brain drug delivery mediated by polymeric nanoparticles: influence of PEG surface coating	30
Gastro-retentive drug delivery systems: a recent update on clinical pertinence and drug delivery	30
Direct cyclodextrin-based powder extrusion 3D printing for one-step production of the BCS class II model drug niclosamide	29
Applications of cold atmospheric plasma for transdermal drug delivery: a review	29
Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases	29
Novel nanocrystal-based formulations of apremilast for improved topical delivery	28
Soluplus® polymeric nanomicelles improve solubility of BCS-class II drugs	27
Enzymatically crosslinked tyramine-gellan gum hydrogels as drug delivery system for rheumatoid arthritis treatment	27
Inhaled antibodies: formulations require specific development to overcome instability due to nebulization	27
Modulating chitosan-PLGA nanoparticle properties to design a co-delivery platform for glioblastoma therapy intended for nose-to-brain route	26
Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections	26
Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies	26
Microneedle-based insulin transdermal delivery system: current status and translation challenges	26
Advances in 4D printing: from stimulation to simulation	26
Nano-fats for bugs: the benefits of lipid nanoparticles for antimicrobial therapy	26
Antimicrobial nanomedicine for ocular bacterial and fungal infection	26
Inflammation-responsive delivery systems for the treatment of chronic inflammatory diseases	26
Nanocomposite systems for precise oral delivery of drugs and biologics	25
Microfluidic chip connected to porous microneedle array for continuous ISF sampling	25
Titanium dioxide nanotubes as drug carriers for infection control and osteogenesis of bone implants	25
Advances in microneedle-based transdermal delivery for drugs and peptides	25
Nanoemulsion-based dissolving microneedle arrays for enhanced intradermal and transdermal delivery	25
Transdermal drug delivery systems for fighting common viral infectious diseases	25
In vitro dissolution testing models of ocular implants for posterior segment drug delivery	24
Amorphous solid dispersion of nisoldipine by solvent evaporation technique: preparation, characterization, in vitro, in vivo evaluation, and scale up feasibility study	24
Zein-based nanoparticles for the oral delivery of insulin	24
Chondroitin sulfate conjugation facilitates tumor cell internalization of albumin nanoparticles for brain-targeted delivery of temozolomide via CD44 receptor-mediated targeting	24
Natural polysaccharide-based biodegradable polymeric platforms for transdermal drug delivery system: a critical analysis	23
The combination of nanotechnology and traditional Chinese medicine (TCM) inspires the modernization of TCM: review on nanotechnology in TCM-based drug delivery systems	23
Novel rhein–phospholipid complex targeting skin diseases: development, in vitro, ex vivo, and in vivo studies	23

Ovalbumin and cholera toxin delivery to buccal mucus for immunization using microneedles and comparison of immunological response to transmucosal delivery	23
Development, characterization, and anti-leishmanial activity of topical amphotericin B nanoemulsions	22
Besifloxacin-loaded ocular nanoemulsions: design, formulation and efficacy evaluation	22
Improving sciatic nerve regeneration by using alginate/chitosan hydrogel containing berberine	22
Development and approval of rybelsus (oral semaglutide): ushering in a new era in peptide delivery	22
Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins	21
Mesenchymal stem cells’ seeded amniotic membrane as a tissue-engineered dressing for wound healing	21
New pectin-based hydrogel containing imiquimod-loaded polymeric nanocapsules for melanoma treatment	21
A review on multivesicular liposomes for pharmaceutical applications: preparation, characterization, and translational challenges	21
Biosynthesis of gold nanoparticles using leaf extract of Dittrichia viscosa and in vivo assessment of its anti-diabetic efficacy	21
SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics	21
A safety, tolerability, and pharmacokinetic study of a novel simvastatin silica-lipid hybrid formulation in healthy male participants	21
Advances in vaccine delivery systems against viral infectious diseases	21
Formulation and evaluation of transdermal nanogel for delivery of artemether	21
Preparation and characterization of 3D printed PLA microneedle arrays for prolonged transdermal drug delivery of estradiol valerate	20
Simultaneous delivery of anti-miRNA and docetaxel with supramolecular self-assembled “chitosome” for improving chemosensitivity of triple negative breast cancer cells	20
Impact of the mucoadhesive lyophilized wafer loaded with novel carvedilol nano-spanlastics on biochemical markers in the heart of spontaneously hypertensive rat models	20
A novel method for fabrication of coated microneedles with homogeneous and controllable drug dosage for transdermal drug delivery	20
Supersaturated LFCS type III self-emulsifying delivery systems of sorafenib tosylate with improved biopharmaceutical performance: QbD-enabled development and evaluation	20
Hot liquid extrusion assisted drug-cyclodextrin complexation: a novel continuous manufacturing method for solubility and bioavailability enhancement of drugs	20
γ-Cyclodextrin metal–organic framework as a carrier to deliver triptolide for the treatment of hepatocellular carcinoma	20
Black phosphorus nanosheets and docetaxel micelles co-incorporated thermoreversible hydrogel for combination chemo-photodynamic therapy	20
Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control	19
Nano-based anti-tubercular drug delivery: an emerging paradigm for improved therapeutic intervention	19
Simvastatin-loaded nano-niosomes confer cardioprotection against myocardial ischemia/reperfusion injury	19
Non-dermal applications of microneedle drug delivery systems	19
Lipid-based emulsion drug delivery systems — a comprehensive review	19
Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials	19
A chitosan-based nanosystem as pneumococcal vaccine delivery platform	19
Topographical nanostructures for physical sterilization	18
Effect of surfactant concentration and sterilization process on intraocular pressure–lowering activity of Δ9-tetrahydrocannabinol-valine-hemisuccinate (NB1111) nanoemulsions	18
Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA	18
Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective	18
Engineering biomaterials to prevent post-operative infection and fibrosis	18
Recent advances in nanocarriers for nutrient delivery	18
Intelligent automated drug administration and therapy: future of healthcare	18
Testing of aerosolized ciprofloxacin nanocarriers on cystic fibrosis airway cells infected with P. aeruginosa biofilms	18
Nanomedicines in the treatment of colon cancer: a focus on metallodrugs	18
Response surface optimization of biocompatible elastic nanovesicles loaded with rosuvastatin calcium: enhanced bioavailability and anticancer efficacy	18
Repurposing drug molecules for new pulmonary therapeutic interventions	18
Curcumin, a potent therapeutic nutraceutical and its enhanced delivery and bioaccessibility by pickering emulsions	18
Nanobiotechnological modules as molecular target tracker for the treatment and prevention of malaria: options and opportunity	17
A triple combination 'nano' dry powder inhaler for tuberculosis: in vitro and in vivo pulmonary characterization	17
Design and development of polymethylmethacrylate-grafted gellan gum (PMMA-g-GG)-based pH-sensitive novel drug delivery system for antidiabetic therapy	17
Investigating hesperetin nanocrystals with tailor-made sizes for the prevention and treatment of Alzheimer’s disease	17
Mucosal and transdermal vaccine delivery strategies against COVID-19	17
The exosome: a review of current therapeutic roles and capabilities in human reproduction	17
Mannose-conjugated chitosan nanoparticles for delivery of Rifampicin to Osteoarticular tuberculosis	17
Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals	17
Chitosan-based particulate systems for drug and vaccine delivery in the treatment and prevention of neglected tropical diseases	17
Labeling PLA-PEG nanocarriers with IR780: physical entrapment versus covalent attachment to polylactide	17
Nanocarriers for cancer nano-immunotherapy	17
Pulmonary delivery of osimertinib liposomes for non-small cell lung cancer treatment: formulation development and in vitro evaluation	17
Design and development of insulin microneedles for diabetes treatment	17
3D bioprinted scaffolds for diabetic wound-healing applications	17
Synergistic and receptor-mediated targeting of arthritic joints via intra-articular injectable smart hydrogels containing leflunomide-loaded lipid nanocarriers	17
Formulation and optimization of microsponge-loaded emulgel to improve the transdermal application of acyclovir—a DOE based approach	17
Promising bioadhesive ofloxacin-loaded polymeric nanoparticles for the treatment of ocular inflammation: formulation and in vivo evaluation	16
In vitro release, ex vivo penetration, and in vivo dermatokinetics of ketoconazole-loaded solid lipid nanoparticles for topical delivery	16
Development of a novel nanoemulgel formulation containing cumin essential oil as skin permeation enhancer	16
Carboxymethyl-β-glucan/chitosan nanoparticles: new thermostable and efficient carriers for antigen delivery	16
Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting	16
Engineering of 2D nanomaterials to trap and kill SARS-CoV-2: a new insight from multi-microsecond atomistic simulations	16
Thermosensitive and mucoadhesive hydrogel containing curcumin-loaded lipid-core nanocapsules coated with chitosan for the treatment of oral squamous cell carcinoma	16
Rebaudioside A/TPGS mixed nanomicelles as promising nanocarriers for nimodipine ocular delivery	16
Asymmetric flow field-flow fractionation as a multifunctional technique for the characterization of polymeric nanocarriers	16
Quality by design (QbD)–based fabrication of atazanavir-loaded nanostructured lipid carriers for lymph targeting: bioavailability enhancement using chylomicron flow block model and toxicity studies	16
Radiation-synthesis of chitosan/poly (acrylic acid) nanogel for improving the antitumor potential of rutin in hepatocellular carcinoma	16
Co-delivery of cisplatin and siRNA through hybrid nanocarrier platform for masking resistance to chemotherapy in lung cancer	16
Dextran sulfate–modified pH-sensitive layered double hydroxide nanocomposites for treatment of rheumatoid arthritis	15
Nanotherapeutics in autophagy: a paradigm shift in cancer treatment	15
Extracellular vesicle–based drug delivery in cancer immunotherapy	15
Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus®—glycyrrhizic acid mixed micelle system	15
Microemulsion systems: from the design and architecture to the building of a new delivery system for multiple-route drug delivery	15
Posaconazole micelles for ocular delivery: in vitro permeation, ocular irritation and antifungal activity studies	15
A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin	15
Albumin nanoparticles coated with polysorbate 80 for the targeted delivery of antiepileptic drug levetiracetam into the brain	15
Nanoparticle-mediated macrophage targeting—a new inhalation therapy tackling tuberculosis	14
Characterization of commercial PLGAs by NMR spectroscopy	14
Ocular films versus film-forming liquid systems for enhanced ocular drug delivery	14

Gellan gum–based in situ gelling ophthalmic nanosuspension of Posaconazole	14
Nanotechnological interventions for treatment of trypanosomiasis in humans and animals	14
Lipid-based nanosystems for targeting bone implant-associated infections: current approaches and future endeavors	14
Overcoming delivery barriers in immunotherapy for glioblastoma	14
Current status and future of delivery systems for prevention and treatment of infections in the oral cavity	14
Amniotic membrane mesenchymal stem cells labeled by iron oxide nanoparticles exert cardioprotective effects against isoproterenol (ISO)-induced myocardial damage by targeting inflammatory MAPK/NF-κB p	14
Manufacturing readiness assessment for evaluation of the microneedle array patch industry: an exploration of barriers to full-scale manufacturing	14
Bone regeneration in osteoporosis: opportunities and challenges	14
Dissolving microneedle rollers for rapid transdermal drug delivery	13
Predicting topical drug clearance from the skin	13
Local administration of submicron particle paclitaxel to solid carcinomas induces direct cytotoxicity and immune-mediated tumoricidal effects without local or systemic toxicity: preclinical and clinic	13
Irinotecan and berberine co-delivery liposomes showed improved efficacy and reduced intestinal toxicity compared with Onivyde for pancreatic cancer	13
Enzyme-responsive smart nanocarriers for targeted chemotherapy: an overview	13
Role of folate-conjugated glycol-chitosan nanoparticles in modulating the activated macrophages to ameliorate inflammatory arthritis: in vitro and in vivo activities	13
Fabrication of microneedle patches with lyophilized influenza vaccine suspended in organic solvent	13
Synthesis and evaluation of wound healing properties of hydro-diab hydrogel loaded with green-synthetized AGNPS: in vitro and in ex vivo studies	13
Surface-engineered nanostructured lipid carrier systems for synergistic combination oncotherapy of non-small cell lung cancer	13
Controlled release of pharmaceutical agents using eutectic modified gelatin	13
Development of a novel rapamycin loaded nano- into micro-formulation for treatment of lung inflammation	13
Hydroxycamptothecin (HCPT)-loaded PEGlated lipid–polymer hybrid nanoparticles for effective delivery of HCPT: QbD-based development and evaluation	13
Transdermal delivery of a somatostatin receptor type 2 antagonist using microneedle patch technology for hypoglycemia prevention	12
miR-29b and retinoic acid co-delivery: a promising tool to induce a synergistic antitumoral effect in non-small cell lung cancer cells	12
Exploration into the opinions of patients with HIV, healthcare professionals and the lay public of the use of microneedles in clinical practice: highlighting the translational potential for their role	12
Molecular perspective of efficiency and safety problems of chemical enhancers: bottlenecks and recent advances	12
Piribedil loaded thermo-responsive nasal in situ gelling system for enhanced delivery to the brain: formulation optimization, physical characterization, and in vitro and in vivo evaluation	12
Fused deposition modeling three-dimensional printing of flexible polyurethane intravaginal rings with controlled tunable release profiles for multiple active drugs	12
Physicochemical characterization and in vitro biological evaluation of solid compounds from furazolidone-based cyclodextrins for use as leishmanicidal agents	12
Osteointegration, antimicrobial and antibiofilm activity of orthopaedic titanium surfaces coated with silver and strontium-doped hydroxyapatite using a novel blasting process	12
Tailoring drug co-delivery nanosystem for mitigating U-87 stem cells drug resistance	12
Are lipid nanoparticles really superior? A holistic proof of concept study	12
Preparation and evaluation of long circulating erythrocyte membrane-cloaked anti-cancer drug delivery system	12
From the laboratory to the end-user: a primary packaging study for microneedle patches containing amoxicillin sodium	12
Carrageenan from red algae: an application in the development of inhalable tuberculosis therapy targeting the macrophages	12
Dermal delivery and follicular targeting of adapalene using PAMAM dendrimers	11
Release mechanisms of bovine serum albumin loaded–PLGA microspheres prepared by ultra-fine particle processing system	11
Internalizing RGD, a great motif for targeted peptide and protein delivery: a review article	11
Bioavailability enhancement of vitamin E TPGS liposomes of nintedanib esylate: formulation optimization, cytotoxicity and pharmacokinetic studies	11
Convection-enhanced delivery of liposomal drugs for effective treatment of glioblastoma multiforme	11
A sustained release cysteamine microsphere/thermoresponsive gel eyedrop for corneal cystinosis improves drug stability	11
Pharmaceutical design of a delivery system for the bacteriocin lacticin 3147	11
Long-acting injectable PLGA/PLA depots for leuprolide acetate: successful translation from bench to clinic	11
A comparative biodistribution study of polymeric and lipid-based nanoparticles	11
A hypotonic gel-forming eye drop provides enhanced intraocular delivery of a kinase inhibitor with melanin-binding properties for sustained protection of retinal ganglion cells	11
Recent progress of macrophage vesicle-based drug delivery systems	11
Exploring paclitaxel-loaded adenosine-conjugated PEGylated PLGA nanoparticles for targeting triple-negative breast cancer	11
Evaluating nanobiomaterial-induced DNA strand breaks using the alkaline comet assay	11
Transdermal delivery for gene therapy	11
Targeted nano-delivery of chemotherapy via intranasal route suppresses in vivo glioblastoma growth and prolongs survival in the intracranial mouse model	11
Targeting fibroblast activation protein (FAP): advances in CAR-T cell, antibody, and vaccine in cancer immunotherapy	11
Quercetin-biapigenin nanoparticles are effective to penetrate the blood–brain barrier	11
Otoliths-composed gelatin/sodium alginate scaffolds for bone regeneration	11
Delivery of transcription factors as modulators of cell differentiation	10
Enhanced oral bioavailability and antitumor therapeutic efficacy of sorafenib administered in core–shell protein nanoparticle	10
Technological advances in the use of viral and non-viral vectors for delivering genetic and non-genetic cargos for cancer therapy	10
Standardization of an in vitro assay matrix to assess cytotoxicity of organic nanocarriers: a pilot interlaboratory comparison	10
Modelling acute myeloid leukemia (AML): What’s new? A transition from the classical to the modern	10
Future perspectives for advancing regulatory science of nanotechnology-enabled health products	10
Therapeutic applications and delivery systems for triptolide	10
Topical instillation of triamcinolone acetonide-loaded emulsomes for posterior ocular delivery: statistical optimization and in vitro-in vivo studies	10
Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro	10
Nicaraven-loaded electrospun wound dressings promote diabetic wound healing via proangiogenic and immunomodulatory functions: a preclinical investigation	10
Self-luminescent photodynamic therapy and pathogen detection for infectious diseases	10
Nanomedicine in therapeutic warfront against estrogen receptor–positive breast cancer	10
Liquid crystalline nanodispersion functionalized with cell-penetrating peptides improves skin penetration and anti-inflammatory effect of lipoic acid after in vivo skin exposure to UVB radiation	10
Engineered versus hybrid cellular vesicles as efficient drug delivery systems: a comparative study with brain targeted vesicles	10
Single domain antibody-based vectors in the delivery of biologics across the blood–brain barrier: a review	10
Co-delivery systems: hope for clinical application?	10
Nanomedicine-based combination of dexamethasone palmitate and MCL-1 siRNA for synergistic therapeutic efficacy against rheumatoid arthritis	10
Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers	10
An update on microneedle-based systems for diabetes	10
Should local drug delivery systems be used in dentistry?	10
Topical and transdermal delivery with diseased human skin: passive and iontophoretic delivery of hydrocortisone into psoriatic and eczematous skin	10
Shape-specific microfabricated particles for biomedical applications: a review	10
Microimaging of a novel intracochlear drug delivery device in combination with cochlear implants in the human inner ear	10
Enhancing the function of PLGA-collagen scaffold by incorporating TGF-β1-loaded PLGA-PEG-PLGA nanoparticles for cartilage tissue engineering using human dental pulp stem cells	10
Role of three-dimensional cell culture in therapeutics and diagnostics: an updated review	10
Overcoming barriers confronting application of protein therapeutics in bone fracture healing	10
Overcoming biological barriers to improve solid tumor immunotherapy	10
Preparation, characterization, and in vivo evaluation of levonorgestrel-loaded thermostable microneedles	10