Cell Reports

Article	Citations
Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection	361
Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity	309
Q&A with Hao Gu	242
Deep ancestry of Bornean hunter-gatherers supports long-term local ancestry dynamics	218
Atg15 is a vacuolar phospholipase that disintegrates organelle membranes	216
Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses	179
Modification of histidine repeat proteins by inorganic polyphosphate	173
Secretory IgA in breast milk protects against asthma through modulation of the gut microbiota	173
Hierarchical behavioral analysis framework as a platform for standardized quantitative identification of behaviors	166
An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike	165
PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA	157
EWSR1 maintains centromere identity	154
HuR promotes triglyceride synthesis and intestinal fat absorption	149
Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity	147
Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes	145
A vascular-associated fibroblastic cell controls pancreatic islet immunity	144
Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo	140
Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation	137
Multimodal CRISPR screens uncover DDX39B as a global repressor of A-to-I RNA editing	137
Stereotyped goal-directed manifold dynamics in the insular cortex	134
A trans-kingdom T6SS RNase effector targeting both prokaryotic and host cells for pathogenesis	134
Cross-species communication via agr controls phage susceptibility in Staphylococcus aureus	131
Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development	127
The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing	126
Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly	126

PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle	125
An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity	122
The m C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism	122
Energy status orchestrates YTHDF1 phase separation and tumorigenesis	121
Santa-maria is a glial phagocytic receptor that acts with SIMU to recognize and engulf apoptotic neurons	120
Tyzzerella nexilis strains enriched in mobile genetic elements are involved in progressive multiple sclerosis	120
The T cell receptor sequence influences the likelihood of T cell memory formation	119
Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain	119
CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells	117
PAMless SpRY exhibits a preference for the seed region for efficient targeting	116
Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis	115
Epitopes in the capsular polysaccharide and the porin OmpK36 receptors are required for bacteriophage infection of Klebsiella pneumoniae	113
Chemical-induced epigenome resetting for regeneration program activation in human cells	112
CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance	109
MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC	109
Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80/PD-L1 interaction	108
FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress	107
Intravascular immune surveillance against viremia requires spatiotemporal coordination between Kupffer cells and ILC1s	106
Q&A with Bin Cao	105
A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells	105
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression	103
An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma	103
TGF-β Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma	101
Single-cell RNA-seq analysis identifies the atlas of lymph fluid and reveals a sepsis-related T cell subset	100
Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans	100
DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons	99
A type III-Dv CRISPR-Cas system is controlled by the transcription factor RpaB and interacts with the DEAD-box RNA helicase CrhR	99
Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression	99
Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model	99
Sugar detection in 3D: Structure of an insect gustatory receptor	97
The absence of telomerase leads to immune response and tumor regression in zebrafish melanoma	97
Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV	96
Development of pial collaterals by extension of pre-existing artery tips	96
OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase	96
Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells	96
Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and maturation of olfactory sensory neurons	96
Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay	96
Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids	95
CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection	95
FABP5 in skin macrophages mediates saturated fat-induced IL-1β signaling in psoriatic inflammation	95
PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth	94
Retinal glia regulate development of the circadian photoentrainment circuit	94
EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8+ T cells toward less-exhausted phenotypes	93
β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4	93
Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females	93
Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia	92
A robot-rodent interaction arena with adjustable spatial complexity for ethologically relevant behavioral studies	90
SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification	90
The medial entorhinal cortex encodes multisensory spatial information	90
Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy	90

Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy	89
High plasticity of ribosomal DNA organization in budding yeast	89
PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model	89
A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging	88
Optogenetic silencing of medial septal GABAergic neurons disrupts grid cell spatial and temporal coding in the medial entorhinal cortex	88
A secondary metabolite of Limosilactobacillus reuteri R2lc drives strain-specific pathology in a spontaneous mouse model of multiple sclerosis	88
Fibroblast diversification is an embryonic process dependent on muscle contraction	87
Defects in CYB5A and CYB5B impact sterol-C4 oxidation in cholesterol biosynthesis and demonstrate regulatory roles of dimethyl sterols	87
Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations	87
Mitochondrial fusion and cristae reorganization facilitate acquisition of cardiomyocyte identity during reprogramming of murine fibroblasts	86
Genome restructuring and lineage diversification of Cryptococcus neoformans during chronic infection of human hosts	86
CD84 as a therapeutic target for breaking immune tolerance in triple-negative breast cancer	86
Coordinated expression of retained introns and poison exons in renal cell carcinoma	86
HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation	85
53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication	84
The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells	84
Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches	84
Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response	83
PIX is an N-terminal delivery domain that defines a class of polymorphic T6SS effectors in Enterobacterales	83
Unique potential of immature adult-born neurons for the remodeling of CA3 spatial maps	83
Muscle spindles provide flexible sensory feedback for movement sequences	83
Spatiotemporal patterns of neuronal subtype genesis suggest hierarchical development of retinal diversity	82
Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration	82
SoxD genes are required for adult neural stem cell activation	82
Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity	82
Acetylation-dependent regulation of BRAF oncogenic function	81
Single-cell transcriptome profiling and chromatin accessibility reveal an exhausted regulatory CD4+ T cell subset in systemic lupus erythematosus	81
Salmonella enterica serovar Typhimurium uses anaerobic respiration to overcome propionate-mediated colonization resistance	81
Combinatorial Developmental Controls on Striatonigral Circuits	81
In vivo partial cellular reprogramming enhances liver plasticity and regeneration	81
Leave no sister behind	80
Phosphoproteomic profiling of influenza virus entry reveals infection-triggered filopodia induction counteracted by dynamic cortactin phosphorylation	80
Evaluating the impact of age on immune checkpoint therapy biomarkers	80
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors	80
Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation	79
Loss of neuronal heterogeneity in epileptogenic human tissue impairs network resilience to sudden changes in synchrony	79
Direction selectivity of inhibitory interneurons in mouse barrel cortex differs between interneuron subtypes	78
Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity	78
Food-induced dopamine signaling in AgRP neurons promotes feeding	78
A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth	78
Regulation of RNA localization during oocyte maturation by dynamic RNA-ER association and remodeling of the ER	77
APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation	77
Insulin and serine metabolism as sex-specific hallmarks of Alzheimer’s disease in the human hippocampus	77
Cell context-dependent CFI-1/ARID3 functions control neuronal terminal differentiation	76
Actin-dependent astrocytic infiltration is a key step for axon defasciculation during remodeling	76
Cortical mechanisms of visual brightness	76
Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade	76
Supercoiling-mediated feedback rapidly couples and tunes transcription	76
Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code	76
Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer	75
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A	74
Direct type I interferon signaling in hepatocytes controls malaria	74
The OsbHLH002/OsICE1-OSH1 module orchestrates secondary cell wall formation in rice	74
Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy	74
Potentiation of cholinergic and corticofugal inputs to the lateral amygdala in threat learning	74
Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment	73
Coupling to Pam16 differentially controls the dual role of Pam18 in protein import and respiratory chain formation	72
DNA replication is highly resilient and persistent under the challenge of mild replication stress	72
Activity-dependent PI4P synthesis by PI4KIIIα regulates long-term synaptic potentiation	72
SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine	72
Regionally defined proteomic profiles of human cerebral tissue and organoids reveal conserved molecular modules of neurodevelopment	72
Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase	71
MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis	71
Association of B cell profile and receptor repertoire with the progression of Alzheimer’s disease	71
SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones	71
Sugar-responsive inhibition of Myc-dependent ribosome biogenesis by Clockwork orange	71
Tumor-derived Jagged1 promotes cancer progression through immune evasion	71
HNF4A modulates glucocorticoid action in the liver	71
Neutralization fingerprinting technology for characterizing polyclonal antibody responses to dengue vaccines	70
Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infection	70
Laminar mechanisms of saccadic suppression in primate visual cortex	70
Exploring the pan-cancer landscape of posttranscriptional regulation	70
Very-long-chain fatty acids are crucial to neuronal polarity by providing sphingolipids to lipid rafts	69
Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins	69
Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity	69
Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response	69
Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic	68
A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner	68
Memory trace imbalance in reinforcement and punishment systems can reinforce implicit choices leading to obsessive-compulsive behavior	68
Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation	68

EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release	68
Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors	68
Extracellular vesicle-mediated trafficking of molecular cues during human brain development	68
The human placenta shapes the phenotype of decidual macrophages	68
LKB1 prevents ILC2 exhaustion to enhance antitumor immunity	67
The architecture of silk-secreting organs during the final larval stage of silkworms revealed by single-nucleus and spatial transcriptomics	67
piRNA-guided intron removal from pre-mRNAs regulates density-dependent reproductive strategy	67
Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner	67
Genome-wide fetalization of enhancer architecture in heart disease	67
FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis	66
Endophytic mycobiont provides growth benefits via a phenylpropanoid-auxin axis in host plants	66
Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP	66
A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution	66
AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia	66
Gestationally dependent immune organization at the maternal-fetal interface	65
MYB68 regulates radial endodermal differentiation and suberin patterning	65
Piezo1 senses hyphae and initiates host defense against pathogenic fungi	65
A synthetic chlorophagy receptor promotes plant fitness by mediating chloroplast microautophagy	65
Failure of digit tip regeneration in the absence of Lmx1b suggests Lmx1b functions disparate from dorsoventral polarity	65
Chlorophyll biosynthesis under the control of arginine metabolism	65
YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation	65
Mitochondrial cristae architecture protects against mtDNA release and inflammation	64
Structural basis of ligand specificity and channel activation in an insect gustatory receptor	64
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins	64
Distinct TAM subset with cross-dressing capability determines the bifurcation of tumor immunity	64
The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis	64
Compartmentalized PGRP expression along the dipteran Bactrocera dorsalis gut forms a zone of protection for symbiotic bacteria	64
Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages	63
Optogenetic activation of cortical microglia promotes neuronal activity and pain hypersensitivity	63
NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells	63
Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination	63
Loss of the proton-activated chloride channel in neurons impairs AMPA receptor endocytosis and LTD via endosomal hyper-acidification	63
Histone acetyltransferase HAF2 associates with pyruvate dehydrogenase complex to control H3K14ac and H3K23ac in ethylene response	63
Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control	63
Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration	63
p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP	62
T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells	62
Documenting the diversity of the Namibian Ju|’hoansi intestinal microbiome	62
Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions	62
Gene-regulatory programs that specify age-related differences during thymocyte development	61
Randomly barcoded transposon mutant libraries for gut commensals II: Applying libraries for functional genetics	61
Age-dependent glial heterogeneity and traumatic injury responses in a vertebrate brain structure	61
A ribosome-bound tRNA half stimulates mitochondrial translation during stress recovery in Trypanosoma brucei	61
Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses	61
RPGR is a guanine nucleotide exchange factor for the small GTPase RAB37 required for retinal function via autophagy regulation	61
Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling	61
miRNA-mediated inhibition of an actomyosin network in hippocampal pyramidal neurons restricts sociability in adult male mice	61
Septo-subicular cholinergic circuit promotes seizure development via astrocytic inflammation	61
Separation-of-function mutants reveal the NF-κB-independent involvement of IκBα in the regulation of intestinal stemness	61
Multiphasic protein condensation governed by shape and valency	61
Structural basis for ligand recognition of the human hydroxycarboxylic acid receptor HCAR3	60
Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38	60
Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination	60
ERK1/2 interaction with DHPS regulates eIF5A deoxyhypusination independently of ERK kinase activity	60
S1 represents multisensory contexts and somatotopic locations within and outside the bounds of the cortical homunculus	60
The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels	60
Poly-ubiquitylated transmembrane proteins outcompete other cargo for limited space inside clathrin-coated vesicles	59
Regulation of STING activity in DNA sensing by ISG15 modification	59
Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development	59
Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors	59
Toward structural-omics of the bovine retinal pigment epithelium	59
PP2A licenses the FANCD2/FANCI complex for chromosome loading	59
Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail	59
Antibodies against the Ebola virus soluble glycoprotein are associated with long-term vaccine-mediated protection of non-human primates	59
Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression	59
Reverse engineering neuron-type-specific and type-orthogonal splicing-regulatory networks using diverse cellular transcriptomes	59
Bodies in motion: Unraveling the distinct roles of motion and shape in dynamic body responses in the temporal cortex	58
Automated live-cell single-molecule tracking in enteroid monolayers reveals transcription factor dynamics probing lineage-determining function	58
Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood flow during brain hypoxia	58
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis	58
Single-cell multiomics reveals the oscillatory dynamics of mRNA metabolism and chromatin accessibility during the cell cycle	58
Bioengineering for robust tolerance against cold and drought stresses via co-overexpressing three Cu-miRNAs in major food crops	58
General anesthesia activates a central anxiolytic center in the BNST	58
A tug of war between DCC and ROBO1 signaling during commissural axon guidance	58
A regulatory module tunes OsYABBY4 expression to modify vascular bundle development and tillering in rice	58
Mitochondrial transplantation rescues Ca2+ homeostasis imbalance and myocardial hypertrophy in SLC25A3-related hypertrophic cardiomyopathy	57
Multimode neural population coding of diverse innate fear response by mitral and tufted cells	57
Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels	57
RNF13 mediates pH- and Ca2+-dependent regulation of lysosomal positioning	57
Subcellular localization shapes the fate of RNA polymerase III	57
Acute neuroinflammation leads to disruption of neuronal chloride regulation and consequent hyperexcitability in the dentate gyrus	56
G-protein-coupled receptor 84 regulates acute inflammation in normal and diabetic skin wounds	56
Extracellular ATP is an environmental cue in bacteria	56
Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression	56
Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia	56
Dynamic chromatin remodeling in cycling human endometrium at single-cell level	56
Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis	56
CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism	56
A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles	56
TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria	56
Divergent sex-specific effects on a ketogenic diet: Male, but not female, mice exhibit oxidative stress and cellular senescence	55
The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity	55
The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation	55
Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes	55
LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation	55