Cell Reports

Article	Citations
Louder for longer: Myc amplifies gene expression by extended transcriptional bursting	369
Axon targeting of Drosophila medulla projection neurons requires diffusible Netrin and is coordinated with neuroblast temporal patterning	332
Neuropeptide signaling and SKN-1 orchestrate differential responses of the proteostasis network to dissimilar proteotoxic insults	302
Ebola virus delta peptide is an enterotoxin	242
Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection	203
Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease	201
Memory trace imbalance in reinforcement and punishment systems can reinforce implicit choices leading to obsessive-compulsive behavior	199
LRP12 is an endogenous transmembrane inactivator of α4 integrins	193
Tyzzerella nexilis strains enriched in mobile genetic elements are involved in progressive multiple sclerosis	191
Ribosome customization and functional diversification among P-stalk proteins regulate late poxvirus protein synthesis	185
The microglial response to inhibition of Colony-stimulating-factor-1 receptor by PLX3397 differs by sex in adult mice	181
Improved split prime editors enable efficient in vivo genome editing	181
Interrogation of RNA-bound proteome with XRNAX illuminates molecular alterations in the mouse brain affected with dysmyelination	181
Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs	181
Self-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries	179
Physiological shedding and C-terminal proteolytic processing of TMEM106B	178
Luminance invariant encoding in mouse primary visual cortex	177
Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy	176
Identification of modulators of the ALT pathway through a native FISH-based optical screen	171
Multi-omics reveals immune response and metabolic profiles during high-altitude mountaineering	149
The T cell receptor sequence influences the likelihood of T cell memory formation	149
IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth	144
Stub1 maintains proteostasis of master transcription factors in embryonic stem cells	144
Santa-maria is a glial phagocytic receptor that acts with SIMU to recognize and engulf apoptotic neurons	141
Coordinated neuron-specific splicing events restrict nucleosome engagement of the LSD1 histone demethylase complex	141

CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells	141
Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior	139
Hydrogen sulfide mediates the interaction between C. elegans and Actinobacteria from its natural microbial environment	138
Dissociation-related behaviors in mice emerge from the inhibition of retrosplenial cortex parvalbumin interneurons	137
The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation	133
Sox2 in the dermal papilla regulates hair follicle pigmentation	132
SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck	129
Large-scale integration of the non-coding RNAs with DNA methylation in human cancers	129
Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models	128
PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny	128
Dynamic plasticity of prostate cancer intermediate cells during androgen receptor-targeted therapy	128
Nuclear transport surveillance of p53 by nuclear pores in glioblastoma	127
Behavioral modulations can alter the visual tuning of neurons in the mouse thalamocortical pathway	126
PD-1 deficiency impairs eosinophil recruitment to tissue during Trichinella spiralis infection	125
Legionella uses host Rab GTPases and BAP31 to create a unique ER niche	124
The next phase of biomolecular condensate research	121
Carnitine palmitoyltransferase 1 facilitates fatty acid oxidation in a non-cell-autonomous manner	121
Fibroblast diversification is an embryonic process dependent on muscle contraction	121
The absence of telomerase leads to immune response and tumor regression in zebrafish melanoma	120
Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation	117
Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay	116
Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input	115
SMYD5 is a regulator of the mild hypothermia response	113
Q&A with Yan-Gang Sun	113
A simple and scalable zebrafish model of Sonic hedgehog medulloblastoma	113
FolIws1-driven nuclear translocation of deacetylated FolTFIIS ensures conidiation of Fusarium oxysporum	109
A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution	109
Structural insights into IL-6 signaling inhibition by therapeutic antibodies	108
Pneumococcal sialidase promotes bacterial survival by fine-tuning of pneumolysin-mediated membrane disruption	108
Kinetochore and ionomic adaptation to whole-genome duplication in Cochlearia shows evolutionary convergence in three autopolyploids	108
The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis	106
LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans	105
MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance	104
The neurobehavioral correlates of exploration without learning: Trading off value for explicit, prospective, and variable information gains	104
BLMP-1 is a critical temporal regulator of dietary-restriction-induced response in Caenorhabditis elegans	103
Role of the small protein Mco6 in the mitochondrial sorting and assembly machinery	103
Mapping of the influenza A virus genome RNA structure and interactions reveals essential elements of viral replication	103
Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner	100
Complexity of synovial fluid-derived monocyte-macrophage-lineage cells in knee osteoarthritis	99
A human fetal cerebellar map of the late second trimester reveals developmental molecular characteristics and abnormality in trisomy 21	98
The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network	96
Degraded tactile coding in the Cntnap2 mouse model of autism	95
Optogenetic silencing of medial septal GABAergic neurons disrupts grid cell spatial and temporal coding in the medial entorhinal cortex	95
Functional genomic analysis of genes important for Candida albicans fitness in diverse environmental conditions	94
Spatial analysis of murine microbiota and bile acid metabolism during amoxicillin treatment	94
Investigation of MSC potency metrics via integration of imaging modalities with lipidomic characterization	93
Lipid-associated macrophages for osimertinib resistance and leptomeningeal metastases in NSCLC	93
Q&A with Zhentao Zhang	93
Sigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagy	93
TrkC-CreERT2-mediated recombination supports evidence that TrkC+/TH+ DRG neurons contribute to cardiovascular homeostasis	92

Working memory features are embedded in hippocampal place fields	92
PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle	92
Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade	92
Parallel pathways carrying direction-and orientation-selective retinal signals to layer 4 of the mouse visual cortex	92
Circadian regulation of dentate gyrus excitability mediated by G-protein signaling	91
Mitochondrial double-stranded RNAs govern the stress response in chondrocytes to promote osteoarthritis development	91
Empirical versus theoretical power and type I error (false-positive) rates estimated from real murine aging research data	90
DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability	90
TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction	90
Reduced lysosomal density in neuronal dendrites mediates deficits in synaptic plasticity in Huntington’s disease	89
SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ	89
Phasic Off responses of auditory cortex underlie perception of sound duration	89
In situ chemoproteomic profiling reveals itaconate inhibits de novo purine biosynthesis in pathogens	88
An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike	87
AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia	87
A selective p53 activator and anticancer agent to improve colorectal cancer therapy	87
SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine	86
Spontaneous mutagenesis in human cells is controlled by REV1-Polymerase ζ and PRIMPOL	86
NR4A1 transcriptionally regulates the differentiation of stem-like CD8+ T cells in the tumor microenvironment	86
Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2	86
CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection	86
Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action	86
Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens	86
Modification of histidine repeat proteins by inorganic polyphosphate	85
Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal	85
APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation	85
A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging	84
Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity	84
PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes	83
Early chromosome condensation by XIST builds A-repeat RNA density that facilitates gene silencing	82
De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function	82
Coexisting cancer stem cells with heterogeneous gene amplifications, transcriptional profiles, and malignancy are isolated from single glioblastomas	82
A stem cell aging framework, from mechanisms to interventions	82
Cochlear organoids reveal transcriptional programs of postnatal hair cell differentiation from supporting cells	82
Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1 and FFAR2	82
Tspan6 stimulates the chemoattractive potential of breast cancer cells for B cells in an EV- and LXR-dependent manner	81
Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation	81
Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma	81
ZYG11B potentiates the antiviral innate immune response by enhancing cGAS-DNA binding and condensation	81
Hair cell regeneration, reinnervation, and restoration of hearing thresholds in the avian hearing organ	81
Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model	80
Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8+ T cell exhaustion and curtails anti-PD-1 efficacy	80
On the origin and evolution of RNA editing in metazoans	80
Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines	80
Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy	80
Pyochelin biotransformation by Staphylococcus aureus shapes bacterial competition with Pseudomonas aeruginosa in polymicrobial infections	80
Cryo-ET study from in vitro to in vivo revealed a general folding mode of chromatin with two-start helical architecture	80
NF-κB memory coordinates transcriptional responses to dynamic inflammatory stimuli	79
Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade	79
Twist regulates Yorkie activity to guide lineage reprogramming of syncytial alary muscles	78
SoxD genes are required for adult neural stem cell activation	78
Functional diversification and dynamics of CAR-T cells in patients with B-ALL	78
Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment	77
Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein	76
Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation	76
Acetylation-dependent regulation of BRAF oncogenic function	76
Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species	76
Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity	76
Mitochondrial genome recovery by ATFS-1 is essential for development after starvation	76
A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity	75
A guiding role of the Arabidopsis circadian clock in cell differentiation revealed by time-series single-cell RNA sequencing	75
Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells	75
MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses	75
Simultaneous mapping of 3D structure and nascent RNAs argues against nuclear compartments that preclude transcription	75
Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition	74
Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner	74
MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC	73
A homotetrameric hemoglobin expressed in alveolar epithelial cells increases blood oxygenation in high-altitude plateau pika (Ochotona curzoniae)	73
CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis	73
Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly	73
Dendritic cell ICAM-1 strengthens synapses with CD8 T cells but is not required for their early differentiation	73
TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state	73
A transcriptomic and proteomic atlas of obesity and type 2 diabetes in cynomolgus monkeys	73
Spread of pathological human Tau from neurons to oligodendrocytes and loss of high-firing pyramidal neurons in aging mice	72
Assembly and disassembly dynamics of nonmuscle myosin II control endosomal fission	72
Maternal gut microbiota mediate intergenerational effects of high-fat diet on descendant social behavior	72
TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex	72
The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer	72
PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1	72
Gestationally dependent immune organization at the maternal-fetal interface	72

BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis	72
A non-hallucinogenic LSD analog with therapeutic potential for mood disorders	72
MetA is a “thermal fuse” that inhibits growth and protects Escherichia coli at elevated temperatures	71
The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells	71
Extensive de novo activity stabilizes epigenetic inheritance of CG methylation in Arabidopsis transposons	71
SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum	71
Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy	70
Variation in the CENP-A sequence association landscape across diverse inbred mouse strains	70
Tandem LIM domain-containing proteins, LIMK1 and LMO1, directly bind to force-bearing keratin intermediate filaments	69
CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions	69
Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells	69
Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ	69
Spontaneous and evoked synaptic vesicle release arises from a single releasable pool	69
Secreted NF-κB suppressive microbial metabolites modulate gut inflammation	69
Single-cell transcriptomic characterization of sheep conceptus elongation and implantation	69
LKB1 prevents ILC2 exhaustion to enhance antitumor immunity	69
Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers	69
Correction of amygdalar dysfunction in a rat model of fragile X syndrome	68
Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation	68
Single-nucleus RNA sequencing of developing superior colliculus identifies neuronal diversity and candidate mediators of circuit assembly	68
Cyclin O controls entry into the cell-cycle variant required for multiciliated cell differentiation	68
Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV	68
Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression	68
Dietary tryptophan deficiency promotes gut RORγt+ Treg cells at the expense of Gata3+ Treg cells and alters commensal microbiota metabolism	68
An ancient pan-cnidarian microRNA regulates stinging capsule biogenesis in Nematostella vectensis	67
Spatiotemporal patterns of neuronal subtype genesis suggest hierarchical development of retinal diversity	67
Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells	67
State-dependent olfactory processing in freely behaving mice	67
Drosophila CLASP regulates microtubule orientation and dendrite pruning by suppressing Par-1 kinase	66
Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex	66
A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching	66
Prefrontal inhibition drives formation and dynamic expression of probabilistic Pavlovian fear conditioning	66
Early-life vitamin B12 orchestrates lipid peroxidation to ensure reproductive success via SBP-1/SREBP1 in Caenorhabditis elegans	66
Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine	65
Mycobacterial infection aggravates Helicobacter pylori-induced gastric preneoplastic pathology by redirection of de novo induced Treg cells	65
Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors	65
Leave no sister behind	65
Rapid assembly of a polar network architecture drives efficient actomyosin contractility	65
Receptor editing constrains development of phosphatidyl choline-specific B cells in VH12-transgenic mice	65
Regionally defined proteomic profiles of human cerebral tissue and organoids reveal conserved molecular modules of neurodevelopment	65
Conversion of concept-specific decision confidence into integrative introspection in primates	64
CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance	64
Potentiation of cholinergic and corticofugal inputs to the lateral amygdala in threat learning	64
Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting	64
Gene replacement strategies validate the use of functional tags on centromeric chromatin and invalidate an essential role for CENP-AK124ub	64
Generalization indicates asymmetric and interactive control networks for multi-finger dexterous movements	64
Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals	63
An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma	63
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A	63
Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells	63
Reduced female fertility due to sequestration of RNA Pol II by pervasive transcription in exosome RNase-depleted oocytes	63
Genetic determinants of complement activation in the general population	63
Exercise increases information content and affects long-term stability of hippocampal place codes	63
FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress	63
The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions	63
Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation	62
Activity-dependent constraints on catecholamine signaling	62
Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity	62
Chromosome silencing in vitro reveals trisomy 21 causes cell-autonomous deficits in angiogenesis and early dysregulation in Notch signaling	62
Optogenetic manipulation of BMP signaling to drive chondrogenic differentiation of hPSCs	62
DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors	62
Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties	62
EWSR1 maintains centromere identity	62
TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state	61
Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups	61
Tentonin 3/TMEM150C regulates glucose-stimulated insulin secretion in pancreatic β-cells	61
DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling	61
Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways	61
Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation	60
Extinction blunts paraventricular thalamic contributions to heroin relapse	60
STAT3 signaling in B cells controls germinal center zone organization and recycling	60
Sensory processing in external globus pallidus neurons	60
A ONECUT1 regulatory, non-coding region in pancreatic development and diabetes	60
Dynamic immunodominance hierarchy of neutralizing antibody responses to evolving GII.4 noroviruses	60
Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer	60
Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes	60
Ventral hippocampal CA1 modulates pain behaviors in mice with peripheral inflammation	60
The tumor microenvironment is an ecosystem sustained by metabolic interactions	60
Proteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication	59
Septin filament compaction into rings requires the anillin Mid2 and contractile ring constriction	59
Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s	59
Centrosome-dependent microtubule modifications set the conditions for axon formation	59
Local protein synthesis at neuromuscular synapses is required for motor functions	59
Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity	59
Prefrontal solution to the bias-variance tradeoff during reinforcement learning	59
Identification of protein aggregates in the aging vertebrate brain with prion-like and phase-separation properties	59
MEF2A suppresses stress responses that trigger DDX41-dependent IFN production	59
Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging	59
Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge	58
MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer	58
The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins	58
MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis	58
Neuronal figure-ground responses in primate primary auditory cortex	58
Learning-induced biases in the ongoing dynamics of sensory representations predict stimulus generalization	58
Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis	58