Cell Reports

Article	Citations
Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection	368
Q&A with Hao Gu	338
Combinatorial Developmental Controls on Striatonigral Circuits	240
Loss of neuronal heterogeneity in epileptogenic human tissue impairs network resilience to sudden changes in synchrony	221
Regulation of RNA localization during oocyte maturation by dynamic RNA-ER association and remodeling of the ER	191
Actin-dependent astrocytic infiltration is a key step for axon defasciculation during remodeling	189
The OsbHLH002/OsICE1-OSH1 module orchestrates secondary cell wall formation in rice	181
Sugar-responsive inhibition of Myc-dependent ribosome biogenesis by Clockwork orange	175
Distinct TAM subset with cross-dressing capability determines the bifurcation of tumor immunity	172
Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses	169
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression	157
A type III-Dv CRISPR-Cas system is controlled by the transcription factor RpaB and interacts with the DEAD-box RNA helicase CrhR	155
Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay	152
The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells	151
Multimodal CRISPR screens uncover DDX39B as a global repressor of A-to-I RNA editing	146
A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells	141
PAMless SpRY exhibits a preference for the seed region for efficient targeting	137
Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia	137
Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity	136
Potentiation of cholinergic and corticofugal inputs to the lateral amygdala in threat learning	134
Cell context-dependent CFI-1/ARID3 functions control neuronal terminal differentiation	133
Development of pial collaterals by extension of pre-existing artery tips	130
CD84 as a therapeutic target for breaking immune tolerance in triple-negative breast cancer	130
The absence of telomerase leads to immune response and tumor regression in zebrafish melanoma	129
Spatiotemporal patterns of neuronal subtype genesis suggest hierarchical development of retinal diversity	126

Memory trace imbalance in reinforcement and punishment systems can reinforce implicit choices leading to obsessive-compulsive behavior	124
Failure of digit tip regeneration in the absence of Lmx1b suggests Lmx1b functions disparate from dorsoventral polarity	123
Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase	122
PIX is an N-terminal delivery domain that defines a class of polymorphic T6SS effectors in Enterobacterales	122
Genome-wide fetalization of enhancer architecture in heart disease	120
MYB68 regulates radial endodermal differentiation and suberin patterning	120
The medial entorhinal cortex encodes multisensory spatial information	119
Neutralization fingerprinting technology for characterizing polyclonal antibody responses to dengue vaccines	118
Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model	116
Stereotyped goal-directed manifold dynamics in the insular cortex	115
High plasticity of ribosomal DNA organization in budding yeast	113
Chemical-induced epigenome resetting for regeneration program activation in human cells	112
HuR promotes triglyceride synthesis and intestinal fat absorption	112
Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain	110
Tyzzerella nexilis strains enriched in mobile genetic elements are involved in progressive multiple sclerosis	110
A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging	109
SoxD genes are required for adult neural stem cell activation	107
Santa-maria is a glial phagocytic receptor that acts with SIMU to recognize and engulf apoptotic neurons	107
Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression	106
A secondary metabolite of Limosilactobacillus reuteri R2lc drives strain-specific pathology in a spontaneous mouse model of multiple sclerosis	106
SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones	105
Piezo1 senses hyphae and initiates host defense against pathogenic fungi	105
CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells	104
Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV	102
EWSR1 maintains centromere identity	101
Atg15 is a vacuolar phospholipase that disintegrates organelle membranes	101
TGF-β Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma	100
Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo	100
Supercoiling-mediated feedback rapidly couples and tunes transcription	100
Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner	100
Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infection	99
Exploring the pan-cancer landscape of posttranscriptional regulation	99
OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase	99
A vascular-associated fibroblastic cell controls pancreatic islet immunity	98
Single-cell RNA-seq analysis identifies the atlas of lymph fluid and reveals a sepsis-related T cell subset	98
Cortical mechanisms of visual brightness	98
Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and maturation of olfactory sensory neurons	98
Coordinated expression of retained introns and poison exons in renal cell carcinoma	96
53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication	96
Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity	96
Defects in CYB5A and CYB5B impact sterol-C4 oxidation in cholesterol biosynthesis and demonstrate regulatory roles of dimethyl sterols	96
Genome restructuring and lineage diversification of Cryptococcus neoformans during chronic infection of human hosts	95
A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth	95
Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity	94
The human placenta shapes the phenotype of decidual macrophages	94
PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle	93
Direction selectivity of inhibitory interneurons in mouse barrel cortex differs between interneuron subtypes	92
Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy	92
Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response	91
YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation	91

Genetic and chromatin regulation of Pvt1 monoallelic expression	90
Muscle spindles provide flexible sensory feedback for movement sequences	89
Energy status orchestrates YTHDF1 phase separation and tumorigenesis	88
Intravascular immune surveillance against viremia requires spatiotemporal coordination between Kupffer cells and ILC1s	88
Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development	88
Retinal glia regulate development of the circadian photoentrainment circuit	88
Cross-species communication via agr controls phage susceptibility in Staphylococcus aureus	87
The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis	87
The production of the chemokine CCL2 by corneal sensory neurons initiates anti-viral immunity at the cornea and trigeminal ganglion	86
A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution	86
Deep ancestry of Bornean hunter-gatherers supports long-term local ancestry dynamics	85
Acetylation-dependent regulation of BRAF oncogenic function	85
PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth	85
A robot-rodent interaction arena with adjustable spatial complexity for ethologically relevant behavioral studies	85
Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches	85
Hierarchical behavioral analysis framework as a platform for standardized quantitative identification of behaviors	84
Epitopes in the capsular polysaccharide and the porin OmpK36 receptors are required for bacteriophage infection of Klebsiella pneumoniae	84
FABP5 in skin macrophages mediates saturated fat-induced IL-1β signaling in psoriatic inflammation	84
Endophytic mycobiont provides growth benefits via a phenylpropanoid-auxin axis in host plants	84
EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8+ T cells toward less-exhausted phenotypes	84
The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing	83
Coupling to Pam16 differentially controls the dual role of Pam18 in protein import and respiratory chain formation	83
Direct type I interferon signaling in hepatocytes controls malaria	82
Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling	82
Secretory IgA in breast milk protects against asthma through modulation of the gut microbiota	81
Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation	81
EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release	81
DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons	81
CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection	81
Tumor-derived Jagged1 promotes cancer progression through immune evasion	80
CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance	80
Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins	80
Fibroblast diversification is an embryonic process dependent on muscle contraction	79
Phosphoproteomic profiling of influenza virus entry reveals infection-triggered filopodia induction counteracted by dynamic cortactin phosphorylation	79
Association of B cell profile and receptor repertoire with the progression of Alzheimer’s disease	79
Activity-dependent PI4P synthesis by PI4KIIIα regulates long-term synaptic potentiation	79
Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations	78
MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC	78
Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic	78
SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification	78
Regionally defined proteomic profiles of human cerebral tissue and organoids reveal conserved molecular modules of neurodevelopment	76
Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis	76
β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4	76
Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation	76
PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model	75
Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity	75
PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA	75
Single-cell transcriptome profiling and chromatin accessibility reveal an exhausted regulatory CD4+ T cell subset in systemic lupus erythematosus	75
Q&A with Bin Cao	75
Optogenetic silencing of medial septal GABAergic neurons disrupts grid cell spatial and temporal coding in the medial entorhinal cortex	74
Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy	74
Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP	74
The m C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism	74
Compartmentalized PGRP expression along the dipteran Bactrocera dorsalis gut forms a zone of protection for symbiotic bacteria	74
In vivo partial cellular reprogramming enhances liver plasticity and regeneration	73
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A	73
Very-long-chain fatty acids are crucial to neuronal polarity by providing sphingolipids to lipid rafts	73
Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity	72
An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity	72
Salmonella enterica serovar Typhimurium uses anaerobic respiration to overcome propionate-mediated colonization resistance	71
A synthetic chlorophagy receptor promotes plant fitness by mediating chloroplast microautophagy	71
Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females	71
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins	71
Modification of histidine repeat proteins by inorganic polyphosphate	71
An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike	71
Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans	70
Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer	70
Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade	70
Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment	70
Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80/PD-L1 interaction	70
Unique potential of immature adult-born neurons for the remodeling of CA3 spatial maps	69
Revisiting the dispersal history of walnut by analyzing the ancient DNA of walnut remains in Xinjiang, China	69
Laminar mechanisms of saccadic suppression in primate visual cortex	69
Jub-induced phosphorylation of Warts inhibits its activity and recruitment into biomolecular condensates	69
Sugar detection in 3D: Structure of an insect gustatory receptor	69
Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion	69
Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code	68
MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis	68
Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells	68
Structural basis of ligand specificity and channel activation in an insect gustatory receptor	68

The T cell receptor sequence influences the likelihood of T cell memory formation	68
Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly	67
HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation	67
Insulin and serine metabolism as sex-specific hallmarks of Alzheimer’s disease in the human hippocampus	67
A trans-kingdom T6SS RNase effector targeting both prokaryotic and host cells for pathogenesis	67
Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes	67
An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma	66
FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis	66
Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response	66
FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress	66
Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration	66
Extracellular vesicle-mediated trafficking of molecular cues during human brain development	66
Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors	66
LKB1 prevents ILC2 exhaustion to enhance antitumor immunity	66
Mitochondrial fusion and cristae reorganization facilitate acquisition of cardiomyocyte identity during reprogramming of murine fibroblasts	66
The architecture of silk-secreting organs during the final larval stage of silkworms revealed by single-nucleus and spatial transcriptomics	65
HNF4A modulates glucocorticoid action in the liver	65
DNA replication is highly resilient and persistent under the challenge of mild replication stress	65
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors	64
Mitochondrial cristae architecture protects against mtDNA release and inflammation	64
Chlorophyll biosynthesis under the control of arginine metabolism	64
Gestationally dependent immune organization at the maternal-fetal interface	64
Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids	63
piRNA-guided intron removal from pre-mRNAs regulates density-dependent reproductive strategy	63
Food-induced dopamine signaling in AgRP neurons promotes feeding	63
SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine	63
APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation	63
TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response	62
A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner	62
Multimode neural population coding of diverse innate fear response by mitral and tufted cells	62
AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia	62
Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling	62
Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans	62
Limiting Mrs2-dependent mitochondrial Mg2+ uptake induces metabolic programming in prolonged dietary stress	62
Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway	61
Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1	61
Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis	61
Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis	61
A regulatory module tunes OsYABBY4 expression to modify vascular bundle development and tillering in rice	61
SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells	61
CD169+ macrophages identify and eliminate tumor cells in colorectal cancer through CD169/CD43 interaction and FasL-driven apoptosis	61
The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation	60
Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia	60
Structural basis for ligand recognition of the human hydroxycarboxylic acid receptor HCAR3	60
Structural insights into ligand recognition, selectivity, and activation of bombesin receptor subtype-3	59
Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination	59
Histone acetyltransferase HAF2 associates with pyruvate dehydrogenase complex to control H3K14ac and H3K23ac in ethylene response	59
Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination	59
Dynamic chromatin remodeling in cycling human endometrium at single-cell level	59
The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER	59
Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression	59
p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP	59
Optogenetic activation of cortical microglia promotes neuronal activity and pain hypersensitivity	59
Septo-subicular cholinergic circuit promotes seizure development via astrocytic inflammation	59
The C. elegans regulatory factor X (RFX) DAF-19M module: A shift from general ciliogenesis to cell-specific ciliary and behavioral specialization	58
Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration	58
Cadherins modulate the self-organizing potential of pseudo-embryos	58
Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism	58
The soil microbiome modulates the sorghum root metabolome and cellular traits with a concomitant reduction of Striga infection	58
Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts	58
Antibodies against the Ebola virus soluble glycoprotein are associated with long-term vaccine-mediated protection of non-human primates	58
Modulation function of sphingomyelin molecular species in TLR4 signaling and cell death	58
Landscape and regulation of mRNA translation in the early C. elegans embryo	58
Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway	58
Selective targeting of mu opioid receptors to primary cilia	58
Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function	58
Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail	58
Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication	58
LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation	58
CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism	58
Acute neuroinflammation leads to disruption of neuronal chloride regulation and consequent hyperexcitability in the dentate gyrus	58
The ADP-ribose hydrolase NUDT5 is important for DNA repair	58
Phospholipids can regulate complex I assembly independent of their role in maintaining mitochondrial membrane integrity	57
Bioengineering for robust tolerance against cold and drought stresses via co-overexpressing three Cu-miRNAs in major food crops	57
Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood flow during brain hypoxia	57
T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells	57
14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer	57
Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma	57
Midbrain dopamine neurons signal phasic and ramping reward prediction error during goal-directed navigation	56
RPGR is a guanine nucleotide exchange factor for the small GTPase RAB37 required for retinal function via autophagy regulation	56
The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels	56
NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells	56
Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation	56
Documenting the diversity of the Namibian Ju|’hoansi intestinal microbiome	56
Hippocampal and medial prefrontal ensemble spiking represents episodes and rules in similar task spaces	56
GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia	56
Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation	56
Bodies in motion: Unraveling the distinct roles of motion and shape in dynamic body responses in the temporal cortex	56
ERK1/2 interaction with DHPS regulates eIF5A deoxyhypusination independently of ERK kinase activity	56
Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages	56
Regulation of STING activity in DNA sensing by ISG15 modification	56
A ribosome-bound tRNA half stimulates mitochondrial translation during stress recovery in Trypanosoma brucei	56
SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes	56
Subcellular localization shapes the fate of RNA polymerase III	56
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration	55