OOIR: Observatory of International Research

Papers

(The median citation count of International Journal for Parasitology-Drugs and Drug Resistance is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife	105
In vivo efficiency of praziquantel treatment of single-sex Schistosoma japonicum aged three months old in mice	35
CRISPR-Cas13b mediated gene knockdowns in Leishmania infantum	31
Forward genetic analysis of monensin and diclazuril resistance in Eimeria tenella	31
Anthelmintic resistance in equine nematodes: Current status and emerging trends	29
Diethylcarbamazine mediated potentiation of emodepside induced paralysis requires TRP-2 in adult Brugia malayi	28
Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis	27
The presence and relative frequency detection of the levamisole-resistance-associated S168T substitution in hco-acr-8 in Haemonchus contortus	27
Unpacking boxes: identification of novel inhibitors of malaria parasite invasion	25
Comparative transcriptomics of naturally susceptible and resistant Trypanosoma cruzi strains in response to Benznidazole	23
Investigation of risk factors associated with Ancylostoma spp. infection and the benzimidazole F167Y resistance marker polymorphism in dogs from the United States	23
Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis	22
The Haemonchus contortus LGC-39 subunit is a novel subtype of an acetylcholine-gated chloride channel	20
The EamA metabolite transporter does not affect antileishmanial drug susceptibility	19
Identification of new drug candidates against Trichomonas gallinae using high-throughput screening	19
The faecal egg count reduction test: Will identification of larvae to species improve its utility?	18
Recent advances in intestinal helminth parasites of horses in the Asia-Pacific region: Current trends, challenges and future directions	17
Yeast-based assay to identify inhibitors of the malaria parasite sodium phosphate uptake transporter as potential novel antimalarial drugs	17
A national survey of anthelmintic resistance in ascarid and strongylid nematodes in Australian Thoroughbred horses	16
Integrated application of transcriptomics and metabolomics provides insight into the mechanism of Eimeria tenella resistance to maduramycin	16
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target	15
The induction and inhibition of UDP-glycosyltransferases in Haemonchus contortus and their role in the metabolism of albendazole	15
Emergence of Ancylostoma caninum parasites with the benzimidazole resistance F167Y polymorphism in the US dog population	14
Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women	14
Novel heterospirocyclic antimalarials with activity against artemisinin- and multidrug-resistant P. falciparum malaria	14

Current and emerging target identification methods for novel antimalarials	13
Effects of the G-quadruplex-binding drugs quarfloxin and CX-5461 on the malaria parasite Plasmodium falciparum	13
Mechanistic, in-silico and in vitro studies with nitrofurans reveal potent leishmanicidal activity and inhibition of trypanothione reductase	12
Prevalence of antimalarial drug resistance molecular markers in Makenene, central Cameroon	12
In vitro and in vivo activity evaluation and mode of action of broxaldine on Toxoplasma gondii	12
Benzimidazole F167Y polymorphism in the canine hookworm, Ancylostoma caninum: Widespread geographic, seasonal, age, and breed distribution in United States and Canada dogs	12
Thiophene derivatives activity against the protozoan parasite Leishmania infantum	12
In artemisinin-resistant falciparum malaria parasites, mitochondrial metabolic pathways are essential for survival but not those of apicoplast	12
Molecular characterization and analysis of drug resistance-associated protein enolase 2 of Eimeria tenella	11
Phylogenetic and transcriptomic study of aldo-keto reductases in Haemonchus contortus and their inducibility by flubendazole	11
Trialling the SmartWorm® application in New Zealand sheep farms	11
Challenges in applying W.A.A.V.P. criteria to diagnosing triclabendazole resistance in Fasciola hepatica, an example from the Southern Tablelands of New South Wales, Australia	11
Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways	10
Therapeutic advantages of the combined use of closantel and moxidectin in lambs parasitized with resistant gastrointestinal nematodes	10
Anti-malarial activity of HCl salt of SKM13 (SKM13-2HCl)	10
In vivo efficacy of pyrantel pamoate as a post-exposure prophylactic for rat lungworm (Angiostrongylus cantonensis)	10
Nucleoside analogues for the treatment of animal trypanosomiasis	9
Quantitative DNA metabarcoding reveals species composition of a macrocyclic lactone and pyrantel resistant cyathostomin population in the UK	9
Insights from the use of erythropoietin in experimental Chagas disease	9
Dual-targeting proteasome inhibitor ONX-0914 demonstrates potent antiplasmodial activity for malaria treatment	9
Effect of Phlebotomus papatasi on the fitness, infectivity and antimony-resistance phenotype of antimony-resistant Leishmania major Mon-25	9
High-throughput prioritization of target proteins for development of new antileishmanial compounds	9
Ursolic acid induces apoptosis and disrupts host-parasite interactions in Theileria annulata-infected cells	9
Ribosomal protein L27 contributes to virulence and maduramicin resistance in Eimeria tenella	8
Plasmodium RNA triphosphatase validation as antimalarial target	8
Meclonazepam sensitivity of parasitic flatworms correlates with TRPMMCLZ sensitivity to meclonazepam	8
Faecal egg count reduction tests and nemabiome analysis reveal high frequency of multi-resistant parasites on sheep farms in north-east Germany involving multiple strongyle parasite species	8
Evaluating the efficacy of different praziquantel treatment regimens using egg and circulating anodic antigen (CAA) detection methods in a Schistosoma mansoni endemic area in northeastern Brazil	8
P-glycoproteins and amphids: a two-stage trajectory of ivermectin resistance in Caenorhabditis elegans	8
Reflecting on the past and fast forwarding to present day anthelmintic resistant Ancylostoma caninum–A critical issue we neglected to forecast	7
Effect of urea and squaramide IMPDH inhibitors on C. parvum: in vitro trial design impacts the assessment of drug efficacy	7
Efficacy of fenbendazole against gastrointestinal nematodes in naturally infected goats in Maputo Province, Mozambique using in vivo, in vitro and molecular assessment	7
Screening of the activity of sixty essential oils against plasmodium early mosquito stages in vitro and machine learning analysis reveals new putative inhibitors of malaria parasites	7
Acaricide resistance status of livestock ticks from East and West Africa and in vivo efficacy of acaricides to control them	7
Suramin action in African trypanosomes involves a RuvB-like DNA helicase	7
Modified dosing schedule efficacy of fosmidomycin and clindamycin against murine malaria Plasmodium berghei	7
Natural marine products as antiprotozoal agents against amitochondrial parasites	7
Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited	6
A practical miracidial motility assay for assessing Fasciola hepatica sensitivity to compounds in vitro	6
Antiplasmodial activity of pentyloxyamide-based histone deacetylase inhibitors against Plasmodium falciparum parasites	6
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization	6
The effect of sickle cell genotype on the pharmacokinetic properties of artemether-lumefantrine in Tanzanian children	6
A graphical user interface for wrmXpress 2.0 streamlines helminth phenotypic screening	6
Profile of molecular markers of Sulfadoxine-Pyrimethamine-resistant Plasmodium falciparum in individuals living in southern area of Brazzaville, Republic of Congo	5
Revisiting anthelmintic resistance in sheep flocks from São Paulo State, Brazil	5
Robenidine derivatives as potential antischistosomal drug candidates	5
Transcriptional responses to in vitro macrocyclic lactone exposure in Toxocara canis larvae using RNA-seq	5
Inhibition of Giardia duodenalis by isocryptolepine -triazole adducts and derivatives	5
Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity	5
Anti-cryptosporidial efficacy of tricyclic carbazole aminoalcohols in vitro and in vivo	5

Exploring therapeutic approaches against Naegleria fowleri infections through the COVID box	5
Inhibitory effect of morin on aldolase 2 from Eimeria tenella	5
Ouabain, ATPase inhibitor, potentially enhances the effect of polyhexamethylene biguanide on Acanthamoeba castellanii	4
3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity	4
Exploration of the sensitivity to macrocyclic lactones in the canine heartworm (Dirofilaria immitis) in Australia using phenotypic and genotypic approaches	4
Surveillance of single nucleotide polymorphisms correlated to macrocyclic lactone resistance in Dirofilaria immitis from client-owned dogs across the United States	4
Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies	4
Benzaldehyde stimulates autophagy via the sonic hedgehog signaling pathway in mouse brain astrocytes after treatment with Angiostrongylus cantonensis excretory-secretory products	4
Multiple anthelmintic drug resistant Ancylostoma caninum in foxhounds	4
Efficacy of flukicides against Fasciola hepatica and first report of triclabendazole resistance on German sheep farms	4
A multiplexed high throughput screening assay using flow cytometry identifies glycolytic molecular probes in bloodstream form Trypanosoma brucei	4
Identification and characterization of novel marine oxasqualenoid yucatecone against Naegleria fowleri	4
In vitro activity and mechanism of cell death induction of cyanomethyl vinyl ethers derivatives against Trypanosoma cruzi	4
Macrocyclic lactones and ectoparasites control in livestock: Efficacy, drug resistance and therapeutic challenges	4
Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation	3
The first report of macrocyclic lactone resistant cyathostomins in the UK	3
Development of a clinical risk scoring system for artesunate treatment failure prediction in malaria patients	3
Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia	3
Faecal egg count reduction test, deep amplicon sequencing of isotype-1 β-tubulin gene and in ovo larval development assay reveal susceptibility to benzimidazoles of porcine nematodes Oesophagostomum s	3
Comparative structure activity and target exploration of 1,2-diphenylethynes in Haemonchus contortus and Caenorhabditis elegans	3
Rapid detection of mutations in the suspected piperaquine resistance gene E415G-exo in Plasmodium falciparum exonuclease via AS‒PCR and RAA with CRISPR/Cas12a	3
Evaluation of the inhibitory efficacy of quaternary ammonium compounds on in vitro growth of Theileria equi parasite in MASP culture	3
Screening and hit evaluation of a microbial metabolite library against the pathogenic Plasmodium falciparum and Toxoplasma gondii parasites	3
Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice	3
Functional characterization of three G protein-coupled acetylcholine receptors in parasitic nematode Trichinella spiralis	3
Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity	3
Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues	3
In vitro evaluation of Resveratrol as a potential pre-exposure prophylactic drug against Trypanosoma cruzi infection	3
The phosphatase inhibitor BVT-948 can be used to efficiently screen functional sexual development proteins in the malaria parasite Plasmodium berghei	3
Genomic analysis of Indian isolates of Plasmodium falciparum: Implications for drug resistance and virulence factors	3
Anti-protozoal activity and metabolomic analyses of Cichorium intybus L. against Trypanosoma cruzi	3
In vitro screening of the open-access Pandemic Response Box reveals ESI-09 as a compound with activity against Echinococcus multilocularis	3
Evaluation of the inhibitory effects of emodin on Neospora caninum invasion and proliferation in vitro	3
Trichuris muris egg-hatching assay for anthelminthic drug discovery and characterization	3
Antimalarial drug resistance and drug discovery: learning from the past to innovate the future	3
Thieno[3,2-b]pyrrole 5-carboxamides as potent and selective inhibitors of Giardia duodenalis	3
Evaluation of topotecan and 10-hydroxycamptothecin on Toxoplasma gondii: Implications on baseline DNA damage and repair efficiency	3
3′-deoxytubercidin: A potent therapeutic candidate for the treatment of Surra and Dourine	3
Pharmacokinetics of fenbendazole and its bioactive metabolite oxfendazole in northern bobwhite administered an anthelmintic feed	3