OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmaceutica Sinica B is 80. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	1226
Research and development of Chinese anti-COVID-19 drugs	490
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	425
Drug discovery in China: A snapshot of recent progress	362
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	321
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	321
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	310
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	274
A5—A dual-target antiviral compound that rewrites the rules of influenza therapy	271
Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies	253
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	248
Unravelling the target landscape of tranylcypromines for new drug discovery	231
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	216
Table of Contents	209
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	209
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	201
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	179
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	174
The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer	170
Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative	167
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	158
The progress and perspective of nanomedicine in modulating the tumor immune microenvironment	158
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	156
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	155
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	155

Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	154
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	153
Free energy perturbation (FEP)-guided scaffold hopping	152
Cold exposure-induced β-hydroxybutyrate promotes brown fat mitochondrial lipid droplet contact to ameliorate fatty dysfunction and hepatic steatosis	150
Oral administration of probiotic colony-like micro-nano system for immunoregulation of rheumatoid arthritis	139
Reductive stress—a common metabolic feature of obesity and cancer	130
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	129
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	120
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	118
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	116
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	116
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	113
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	112
TeroACT: A terpenoid bioactivity landscape and discovery platform	111
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	110
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	109
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	108
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	108
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	108
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	107
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	106
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	104
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	104
Paeoniflorin alleviates hypobaric hypoxia-triggered lung injury through targeting MEK2 to modulate ERK2–SGK1 signaling	103
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	103
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	102
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma	97
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy	96
Structural biology of HIV-1 reverse transcriptase allosteric inhibitors for drug design	95
Deciphering the significant impact of natural glycosylation on human insulin	94
Engineered cyclic peptide targeting ITGA5 disrupts tumor-stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma	94
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	93
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	92
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation	92
Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges	91
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis	90
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	89
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	88
Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptor	87
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	87
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	86
Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy	86
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease	85
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	84
Table of Contents	84
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	84
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	84
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	83
Five trends of China's pharmaceutical industry in 2022	83
Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway	82

Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	82
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	81
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway	81
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	81
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis	80