OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmaceutica Sinica B is 77. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	1140
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	453
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	395
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	332
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	299
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	277
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	256
Unravelling the target landscape of tranylcypromines for new drug discovery	255
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	251
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	235
Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative	233
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	230
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	226
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	212
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	210
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	205
Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies	198
A5—A dual-target antiviral compound that rewrites the rules of influenza therapy	198
The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer	191
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	190
The progress and perspective of nanomedicine in modulating the tumor immune microenvironment	170
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	163
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	154
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk	149
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	149

Oral administration of probiotic colony-like micro-nano system for immunoregulation of rheumatoid arthritis	145
Reductive stress—a common metabolic feature of obesity and cancer	142
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	141
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	141
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	140
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	138
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	135
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	127
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	126
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	125
Drug discovery in China: A snapshot of recent progress	123
Free energy perturbation (FEP)-guided scaffold hopping	118
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	114
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	110
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	108
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	107
Research and development of Chinese anti-COVID-19 drugs	106
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	105
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	104
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	103
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	102
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	102
CarsiDock-Cov: A deep learning-guided approach for automated covalent docking and screening	102
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	102
Deciphering the significant impact of natural glycosylation on human insulin	99
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	99
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	98
Exemplifying interspecies variation of liposome in vivo fate by the effects of anti-PEG antibodies	97
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy	96
Ferroptosis meets cancer immunotherapy: Overcoming the crosstalk challenges through advanced drug delivery strategies	96
Table of Contents	95
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease	94
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	92
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	91
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	90
Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway	90
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	89
Improved prebiotic-based “shield” equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota	88
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	86
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma	86
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	86
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis	86
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway	86
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	85
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease	85
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation	84
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy	84
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis	81
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	81
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	81

Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	80
Recent advances in developing small-molecule inhibitors against SARS-CoV-2	78
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	77
Remembering your A, B, C's: Alzheimer's disease and ABCA1	77
Engineered cyclic peptide targeting ITGA5 disrupts tumor-stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma	77