OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmaceutica Sinica B is 80. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Editorial of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”	1031
Drug discovery in China: A snapshot of recent progress	478
Research and development of Chinese anti-COVID-19 drugs	432
Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii	393
MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction	372
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	309
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	286
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	245
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	240
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	238
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	236
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	231
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	224
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	215
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	212
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	211
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	198
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	196
Unravelling the target landscape of tranylcypromines for new drug discovery	195
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	192
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	184
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	182
A5—A dual-target antiviral compound that rewrites the rules of influenza therapy	179
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	163
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	157

Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	154
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	153
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	145
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	142
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	142
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk	140
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	137
Reductive stress—a common metabolic feature of obesity and cancer	136
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	133
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	130
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	127
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	127
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	126
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	123
Free energy perturbation (FEP)-guided scaffold hopping	121
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	117
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	116
Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues	114
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	112
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	110
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	106
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	105
Cover Story	104
Exemplifying interspecies variation of liposome in vivo fate by the effects of anti-PEG antibodies	103
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	102
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway	102
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	99
Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge	99
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation	99
Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy	96
Improved prebiotic-based “shield” equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota	95
CarsiDock-Cov: A deep learning-guided approach for automated covalent docking and screening	94
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis	93
Development of Chinese herbal medicine for sensorineural hearing loss	91
Recent advances in developing small-molecule inhibitors against SARS-CoV-2	91
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy	90
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	89
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease	88
Remembering your A, B, C's: Alzheimer's disease and ABCA1	88
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	87
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy	87
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis	87
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	86
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	86
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	85
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	85
Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells	84
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	83
The role of bacteria and its derived biomaterials in cancer radiotherapy	82
Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo	82

Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	82
Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway	82
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	80
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	80
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma	80