OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmaceutica Sinica B is 82. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Editorial of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”	987
Drug discovery in China: A snapshot of recent progress	467
Research and development of Chinese anti-COVID-19 drugs	413
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	388
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	369
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	356
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	355
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	296
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	276
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	254
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	236
Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii	229
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	229
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	229
MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction	228
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	227
Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues	223
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	213
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	207
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	204
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	203
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	191
Unravelling the target landscape of tranylcypromines for new drug discovery	190
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	188
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	185

Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	181
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	180
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	179
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	174
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	160
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	154
Free energy perturbation (FEP)-guided scaffold hopping	151
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	149
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk	144
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	137
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	136
Reductive stress—a common metabolic feature of obesity and cancer	136
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	136
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	133
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	130
An update on oral drug delivery via intestinal lymphatic transport	127
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	127
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	126
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	124
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	123
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	122
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	120
Five trends of China's pharmaceutical industry in 2022	118
Cover Story	117
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	116
Exemplifying interspecies variation of liposome in vivo fate by the effects of anti-PEG antibodies	115
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	111
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway	110
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	109
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	108
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	105
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation	104
Recent advances in developing small-molecule inhibitors against SARS-CoV-2	103
Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge	101
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	99
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	99
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	98
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	98
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	98
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	98
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma	95
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	93
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy	93
Improved prebiotic-based “shield” equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota	91
Development of Chinese herbal medicine for sensorineural hearing loss	90
Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges	89
Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells	87
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	87
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	87
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease	86

Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease	86
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy	85
Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway	84
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	83
Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy	83
The role of bacteria and its derived biomaterials in cancer radiotherapy	83
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis	83
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis	82
Remembering your A, B, C's: Alzheimer's disease and ABCA1	82
Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer	82
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy	82
Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo	82