OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmaceutica Sinica B is 78. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Table of Contents	800
Cover Story	405
EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway	343
A retrospective cohort study of the efficacy and safety of oral azvudine versus nirmatrelvir/ritonavir in elderly hospitalized COVID-19 patients aged over 60 years	337
STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation	328
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	308
Synovial joints: The barometer of systemic inflammation	300
Cover Story	233
Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy	231
Emerging non-antibody‒drug conjugates (non-ADCs) therapeutics of toxins for cancer treatment	228
TRIM21-based degradation strategy for multimeric proteins	202
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells	201
Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as an orally active antitumor agent	200
Design consideration of phthalocyanines as sensitizers for enhanced sono-photodynamic combinatorial therapy of cancer	200
A novel biological sources consistency evaluation method reveals high level of biodiversity within wild natural medicine: A case study of Amynthas earthworms as “Guang Dilong”	192
Cover Story	191
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	186
Table of Contents	183
The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review	178
Small-molecule agents for cancer immunotherapy	175
Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation	175
Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome	174
Self-assembled multifunctional nanotheranostics against circulating tumor clusters in metastatic breast cancer	171
Peroxidase from foxtail millet bran exerts anti-colorectal cancer activity via targeting cell-surface GRP78 to inactivate STAT3 pathway	170
Guest Editors of Special Column on Drug Targets and Drug Development for Alzheimer’s Disease	167

ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells	164
Drug discovery in China: A snapshot of recent progress	159
Traditional Chinese medicine for the treatment of immune-related nephropathy: A review	157
Improving cancer immunotherapy via co-delivering checkpoint blockade and thrombospondin-1 downregulator	156
Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancy	155
Molecular glues modulate protein functions by inducing protein aggregation: A promising therapeutic strategy of small molecules for disease treatment	154
Acid-switchable nanoparticles induce self-adaptive aggregation for enhancing antitumor immunity of natural killer cells	151
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	149
Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning	145
Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS	145
Commentary: Indirect action pattern: A remote and cross-organ pharmacological mechanism for drug innovation	137
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	132
The role of E3 ubiquitin ligases in bone homeostasis and related diseases	132
Nano-drug delivery strategies affecting cancer-associated fibroblasts to reduce tumor metastasis	130
Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB	130
Editor Profiles: Guest Editors of Special Column on A New Era of Nanobiomaterial-based Drug Delivery	130
Editor Profiles: Guest Editors of Special Column on Antiviral Drug Discovery and Pharmacology	125
Table of Contents	121
Commentary: A nearly forgotten class of anti-inflammatory lipid molecules in central nervous system	121
Editorial of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”	121
Cover Story	116
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	111
Targeted isolation of antiviral cinnamoylphloroglucinol-terpene adducts from Cleistocalyx operculatus by building blocks-based molecular networking approach	109
Reprogramming tumor-associated macrophages and inhibiting tumor neovascularization by targeting MANF–HSF1–HSP70-1 pathway: An effective treatment for hepatocellular carcinoma	109
The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions	109
Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria	108
A reporter gene assay for determining the biological activity of therapeutic antibodies targeting TIGIT	107
From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution	107
Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway	106
Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2	104
Research and development of Chinese anti-COVID-19 drugs	103
Approved HIV reverse transcriptase inhibitors in the past decade	103
Construction and characterization of a humanized SLCO1B1 rat model with its application in evaluating the uptake of different statins	101
SARS-CoV-2 spike host cell surface exposure promoted by a COPI sorting inhibitor	100
SMIP-30, a potent and selective PPM1A inhibitor with potential to treat tuberculosis	99
The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer	97
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	97
APOE2 reduces risk of Alzheimer's disease by protection of lysosomes from lipid overloading	95
Neuronal activities drive brain waste clearance through the glymphatic system	92
Boosting with Omicron-specific mRNA vaccine or historical SARS-CoV-2 vaccines elicits discriminating immune responses against Omicron variants	91
Nanomaterials evoke pyroptosis boosting cancer immunotherapy	89
Extracellular vesicles deliver thioredoxin to rescue stem cells from senescence and intervertebral disc degeneration via a feed-forward circuit of the NRF2/AP-1 composite pathway	89
Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function	88
GPC3-mediated lysosome-targeting chimeras (GLTACs) for targeted degradation of membrane proteins	88
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	87
DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis	86
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	85
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	85
Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy	84
Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy	84

“Pincer movement”: Reversing cisplatin resistance based on simultaneous glutathione depletion and glutathione S-transferases inhibition by redox-responsive degradable organosilica hybrid nanoparticles	82
Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1highCD11b+ cells elimination in hepatocellular carcinoma	81
On-demand integrated nano-engager converting cold tumors to hot via increased DNA damage and dual immune checkpoint inhibition	79