Acta Pharmaceutica Sinica B

Article	Citations
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	1226
Research and development of Chinese anti-COVID-19 drugs	490
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	425
Drug discovery in China: A snapshot of recent progress	362
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	321
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	321
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	310
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	274
A5—A dual-target antiviral compound that rewrites the rules of influenza therapy	271
Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies	253
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	248
Unravelling the target landscape of tranylcypromines for new drug discovery	231
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	216
Table of Contents	209
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	209
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	201
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	179
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	174
The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer	170
Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative	167
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	158
The progress and perspective of nanomedicine in modulating the tumor immune microenvironment	158
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	156
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	155
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	155

Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	154
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	153
Free energy perturbation (FEP)-guided scaffold hopping	152
Cold exposure-induced β-hydroxybutyrate promotes brown fat mitochondrial lipid droplet contact to ameliorate fatty dysfunction and hepatic steatosis	150
Oral administration of probiotic colony-like micro-nano system for immunoregulation of rheumatoid arthritis	139
Reductive stress—a common metabolic feature of obesity and cancer	130
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	129
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	120
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	118
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	116
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	116
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	113
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	112
TeroACT: A terpenoid bioactivity landscape and discovery platform	111
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	110
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	109
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	108
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	108
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	108
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	107
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	106
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	104
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	104
Paeoniflorin alleviates hypobaric hypoxia-triggered lung injury through targeting MEK2 to modulate ERK2–SGK1 signaling	103
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	103
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	102
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma	97
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy	96
Structural biology of HIV-1 reverse transcriptase allosteric inhibitors for drug design	95
Deciphering the significant impact of natural glycosylation on human insulin	94
Engineered cyclic peptide targeting ITGA5 disrupts tumor-stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma	94
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	93
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	92
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation	92
Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges	91
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis	90
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	89
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	88
Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptor	87
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	87
Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy	86
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	86
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease	85
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	84
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	84
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	84
Table of Contents	84
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	83
Five trends of China's pharmaceutical industry in 2022	83
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	82

Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway	82
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	81
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway	81
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	81
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis	80
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy	79
Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells	78
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	78
Exemplifying interspecies variation of liposome in vivo fate by the effects of anti-PEG antibodies	78
Development of Chinese herbal medicine for sensorineural hearing loss	77
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease	77
Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer	77
Recent advances in developing small-molecule inhibitors against SARS-CoV-2	77
Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge	76
Improved prebiotic-based “shield” equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota	76
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	75
The role of bacteria and its derived biomaterials in cancer radiotherapy	74
Remembering your A, B, C's: Alzheimer's disease and ABCA1	74
CarsiDock-Cov: A deep learning-guided approach for automated covalent docking and screening	73
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	72
Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo	71
Ferroptosis meets cancer immunotherapy: Overcoming the crosstalk challenges through advanced drug delivery strategies	71
Table of Contents	71
The epigenetic landscape of rheumatoid arthritis: Pathogenesis and drug therapeutic potentials	70
Tertiary lymphoid structures: The touchstone for tumor immunotherapy	70
Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines	70
ROS-degradable polythioketal urethane scaffold for porcine wound repair	70
Synergistic metabolic modulation of fibroblast-like synoviocytes via targeted dual prodrug nanoparticles to mitigate rheumatoid arthritis	69
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer	69
JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes	68
USP10-mediated deubiquitination and activation of KRAS mutants promotes colorectal cancer via a novel USP10/KRAS positive feedback circuit	68
Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes	68
Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer	68
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins	68
A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy	68
Astrocyte FGF7/FGFR2 autocrine signaling mediates neuroinflammation and promotes MPTP-induced degeneration of dopaminergic neurons	68
Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy	67
Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo	67
Viral miRNA-mediated activation of hyaluronan production as a drug target against COVID-19	66
Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism	66
Intravenous delivery of STING agonists using acid-sensitive polycationic polymer-modified lipid nanoparticles for enhanced tumor immunotherapy	65
Immunocyte reprogramming empowers live-cell drug delivery: Mechanistic insights, delivery strategies, and clinical perspectives	65
Advances in development of antiviral strategies against respiratory syncytial virus	65
Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/P	64
Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives	64
CELMoD–antibody conjugates unlock a CD38 feedback loop in multiple myeloma	64
Biomimetic nitric oxide nanogenerators for synergistic gas-mild photothermal therapy of large solid tumor	64
Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-huma	63
Nanoparticles with rough surface improve the therapeutic effect of photothermal immunotherapy against melanoma	63
Metal nanoparticles for cancer therapy: Precision targeting of DNA damage	62
Dihydromyricetin mitigates abdominal aortic aneurysm via transcriptional and post-transcriptional regulation of heme oxygenase-1 in vascular smooth muscle cells	62
Biomimetic nanomedicines for precise atherosclerosis theranostics	61
Inhibiting collagen I production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles	61
Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment	60
Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy	60
Mitochondrial transplantation as a promising therapy for mitochondrial diseases	60
Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency	59
Recent advances to address challenges in extracellular vesicle-based applications for lung cancer	59
PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism	59
Recent advances in the bench-to-bedside translation of cancer nanomedicines	59
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins	59
Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles	59
Erratum to “Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis” [Acta Pharm Sin B 14 (2024) 3493–3512]	58
The role of botanical triterpenoids and steroids in bile acid metabolism, transport, and signaling: Pharmacological and toxicological implications	58
Cover Story	57
Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants	57
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma	57
DNA origami nanodevice with spatial regulation of CD95 signaling for rheumatoid arthritis treatment	57
Cover Story	56
Spatiotemporally delivery of Cas9 ribonucleoprotein/DNAzyme logic systems using near-infrared upconversion nanomachine for precise immunotherapy	56
Oral garlic-derived nanoparticles improve cancer immunotherapy	56
Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19	55
A chromosome-level Dendrobium moniliforme genome assembly reveals the regulatory mechanisms of flavonoid and carotenoid biosynthesis pathways	55
Table of Contents	55
Editor Profiles: Guest Editors of Special Column on Nanomedicines for Tumor Microenvironment Modulation	54
Table of Contents	54
Gut microbiota drives the metabolic dysregulation in obesity-prone individuals by impairing GDCA-mediated activation of brown adipose thermogenesis and ileal GLP-1 secretion	54
Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis	54
Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma: New opportunities towards molecularly targeted therapy	54
An integrated resource for ischemic heart disease defines hallmarks and heterogeneity across time and space	54

Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing	53
Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis	53
Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy	53
Microneedle-facilitated Portulaca oleracea L.-derived nanovesicles ameliorate atopic dermatitis by modulating macrophage M1/M2 polarization and inhibiting NF-κB and STING signaling pathways	53
Deubiquitination complex platform: A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes	53
PKCα inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability	53
Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect	53
Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer	52
Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1	52
MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B	52
Microglial APOE4 promotes neuron degeneration in Alzheimer's disease through inhibition of lipid droplet autophagy	52
Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling	52
Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis	52
Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment	52
Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1	52
A hybrid bacterium with tumor-associated macrophage polarization for enhanced photothermal-immunotherapy	51
Immune organoid for cancer immunotherapy	51
Transient induction of actin cytoskeletal remodeling associated with dedifferentiation, proliferation, and redifferentiation stimulates cardiac regeneration	51
Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy	51
Cover Story	50
Engineering nanomedicines for immunogenic eradication of cancer cells: Recent trends and synergistic approaches	50
Harnessing the UDP-G/P2Y14R axis to promote liver regeneration in acute liver failure	50
Emerging delivery systems based on aqueous two-phase systems: A review	50
FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis	50
Emerging trends in organ-on-a-chip systems for drug screening	50
Precise assembly of inside-out cell membrane camouflaged nanoparticles via bioorthogonal reactions for improving drug leads capturing	50
Ferrum@albumin assembled nanoclusters inhibit NF-κB signaling pathway for NIR enhanced acute lung injury immunotherapy	49
Electrochemical biosensors with right-side-out-oriented cell membrane coating for the evaluation of AChE inhibitors as potential anti-Alzheimer's disease agents	49
Unveiling the metabolic fate of drugs through metabolic reaction-based molecular networking	49
Palmitoylated SARM1 targeting P4HA1 promotes collagen deposition and myocardial fibrosis: A new target for anti-myocardial fibrosis	48
Cover Story	48
Author correction to ‘Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo’ [Acta Pharmaceutica	48
Targeting PARylated RACK1/HIF-1α axis: A novel mechanism in acute kidney injury and therapeutic promise	48
Analysis of new drug registration and review in China in 2021	47
Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy	47
WITHDRAWN: A neurovascular dual-targeting platelet-like bioinspired nanoplatform for ischemic stroke treatment	47
Identification of human LDHC4 as a potential target for anticancer drug discovery	47
Cover Story	47
Cover Story	46
Author correction to ‘Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling’ [Acta Pharmaceutica Sinica B 12 (2022) 1198–	46
A micro-sized vaccine based on recombinant Lactiplantibacillus plantarum fights against SARS-CoV-2 infection via intranasal immunization	46
Table of Contents	46
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer	46
Table of Contents	46
Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer	45
Unlocking the potential of the gut microbiome in liver regeneration: Benefits and mechanistic insights	45
Author correction to “PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism” [Acta Pharm Sin B 13 (2023) 157–173]	45
Attenuated Salmonella secreting interleukin-21 activates T-cells and induces anti-tumor effects	45
Targeting RAF dimers in RAS mutant tumors: From biology to clinic	45
The ubiquitin–proteasome system: A potential target for the MASLD	44
Mucosal delivery of nanovaccine strategy against COVID-19 and its variants	44
mIgM-mediated splenic marginal zone B cells targeting of folic acid for immunological evasion	44
Engineered tumor specific AAV for IL-12 delivery in ovarian cancer immunotherapy	44
Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations	43
USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitination	43
High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation	43
Development of a novel 18F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography	42
Palmitoylation of Tfr1 enhances platelet ferroptosis and liver injury in heat stroke	42
Advancements and challenges in immunocytokines: A new arsenal against cancer	42
Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis	42
Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib	42
Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment	42
Inhibition of CCT5-mediated asparagine biosynthesis and anti-PD-L1 produce synergistic antitumor effects in colorectal cancer	41
PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids	41
The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells	41
Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine	41
Translating bacteriophage-derived depolymerases into antibacterial therapeutics: Challenges and prospects	41
Artificial intelligence for radiopharmaceutical and molecular imaging	41
Single-domain antibodies as therapeutics for solid tumor treatment	41
Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling	40
Discovery of highly potent phosphodiesterase-1 inhibitors by a combined-structure free energy perturbation approach	40
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression	40
Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure	40
Small-sized twin-nanoparticles normalize tumor vasculature to enhance tumor accumulation and penetration for potent eradication of cancer stem-like cells	39
Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus	39
Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis	39
Cover Story	39
Author correction to “Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy” [Acta Pharm Sin B (2022) 4224–4234]	39
Targeting the coronavirus membrane protein: A promising novel therapeutic strategy	39
Next-generation clinically relevant antibody detection: Unlocking electrochemical biosensors for critical disease management	39
Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing	39
Binary pyroptosis-amplified self-assembling prodrug nanomedicine enhances immunogenicity and inhibits abdominal metastasis in ovarian cancer	39
Author correction to “Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metas	39
Tranexamic acid-fatty alcohol polyoxyethylene ether conjugation/PVA foam for venous sclerotherapy via vascular damage and inhibiting plasmin system	39
Cover Story	39
Deciphering the biological fate of mRNA-LNP-based biologics: A perspective from tissue to intracellular distribution	39
An innovative and stable mRNA-LNP microneedle vaccine elicits humoral and multifunctional cellular immune responses	38
Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signalling	38
Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection	38
AKR1C1 interacts with STAT3 to increase intracellular glutathione and confers resistance to oxaliplatin in colorectal cancer	38
Photoimmunological hydrogel vaccine creates a supportive immune niche to promote antigen cross-presentation cascade and cancer-immunity cycle progression	38
Machine learning empowered formulation design, optimization and characterization of nanoparticulate drug delivery systems: Current applications, challenges, and future perspectives	38
Structures and functions of the MICOS: Pathogenesis and therapeutic implications in Alzheimer's disease	38
Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein	38
A lipid nanosystem establishes precise NO concentration gradient around tumor vessels via endothelial transcytosis, thereby normalizing tumor vasculature and creating an environment beneficial for ant	38