Acta Pharmaceutica Sinica B

Article	Citations
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	1140
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	453
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	395
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	332
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	299
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	277
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	256
Unravelling the target landscape of tranylcypromines for new drug discovery	255
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	251
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	235
Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative	233
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	230
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	226
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	212
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	210
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	205
Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies	198
A5—A dual-target antiviral compound that rewrites the rules of influenza therapy	198
The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer	191
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	190
The progress and perspective of nanomedicine in modulating the tumor immune microenvironment	170
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	163
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	154
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk	149
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	149

Oral administration of probiotic colony-like micro-nano system for immunoregulation of rheumatoid arthritis	145
Reductive stress—a common metabolic feature of obesity and cancer	142
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	141
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	141
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	140
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	138
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	135
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	127
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	126
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	125
Drug discovery in China: A snapshot of recent progress	123
Free energy perturbation (FEP)-guided scaffold hopping	118
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	114
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	110
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	108
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	107
Research and development of Chinese anti-COVID-19 drugs	106
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	105
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	104
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	103
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	102
CarsiDock-Cov: A deep learning-guided approach for automated covalent docking and screening	102
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	102
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	102
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	99
Deciphering the significant impact of natural glycosylation on human insulin	99
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	98
Exemplifying interspecies variation of liposome in vivo fate by the effects of anti-PEG antibodies	97
Ferroptosis meets cancer immunotherapy: Overcoming the crosstalk challenges through advanced drug delivery strategies	96
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy	96
Table of Contents	95
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease	94
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	92
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	91
Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway	90
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	90
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	89
Improved prebiotic-based “shield” equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota	88
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis	86
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway	86
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	86
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma	86
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	86
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease	85
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	85
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy	84
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation	84
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	81
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	81
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis	81

Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	80
Recent advances in developing small-molecule inhibitors against SARS-CoV-2	78
Remembering your A, B, C's: Alzheimer's disease and ABCA1	77
Engineered cyclic peptide targeting ITGA5 disrupts tumor-stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma	77
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	77
Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer	76
Five trends of China's pharmaceutical industry in 2022	76
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	76
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	76
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	76
The role of bacteria and its derived biomaterials in cancer radiotherapy	76
Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge	74
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy	74
Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells	74
Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo	73
Development of Chinese herbal medicine for sensorineural hearing loss	73
Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy	73
Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges	73
Table of Contents	72
The epigenetic landscape of rheumatoid arthritis: Pathogenesis and drug therapeutic potentials	71
ROS-degradable polythioketal urethane scaffold for porcine wound repair	71
Astrocyte FGF7/FGFR2 autocrine signaling mediates neuroinflammation and promotes MPTP-induced degeneration of dopaminergic neurons	70
Recent advances to address challenges in extracellular vesicle-based applications for lung cancer	70
Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines	69
Tertiary lymphoid structures: The touchstone for tumor immunotherapy	69
Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-huma	68
Advances in development of antiviral strategies against respiratory syncytial virus	68
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins	67
Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism	67
Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer	66
Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes	66
The role of botanical triterpenoids and steroids in bile acid metabolism, transport, and signaling: Pharmacological and toxicological implications	66
Intravenous delivery of STING agonists using acid-sensitive polycationic polymer-modified lipid nanoparticles for enhanced tumor immunotherapy	65
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins	65
Synergistic metabolic modulation of fibroblast-like synoviocytes via targeted dual prodrug nanoparticles to mitigate rheumatoid arthritis	65
A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy	64
PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism	64
Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/P	64
Inhibiting collagen I production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles	63
Nanoparticles with rough surface improve the therapeutic effect of photothermal immunotherapy against melanoma	63
Metal nanoparticles for cancer therapy: Precision targeting of DNA damage	63
Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency	63
Recent advances in the bench-to-bedside translation of cancer nanomedicines	63
Viral miRNA-mediated activation of hyaluronan production as a drug target against COVID-19	63
Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles	62
JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes	62
Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives	62
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer	61
Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy	61
Mitochondrial transplantation as a promising therapy for mitochondrial diseases	60
Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment	59
Immunocyte reprogramming empowers live-cell drug delivery: Mechanistic insights, delivery strategies, and clinical perspectives	59
Biomimetic nanomedicines for precise atherosclerosis theranostics	59
Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo	59
Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect	58
A chromosome-level Dendrobium moniliforme genome assembly reveals the regulatory mechanisms of flavonoid and carotenoid biosynthesis pathways	58
Dihydromyricetin mitigates abdominal aortic aneurysm via transcriptional and post-transcriptional regulation of heme oxygenase-1 in vascular smooth muscle cells	58
Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy	58
Editor Profiles: Guest Editors of Special Column on Nanomedicines for Tumor Microenvironment Modulation	58
Erratum to “Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis” [Acta Pharm Sin B 14 (2024) 3493–3512]	58
Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy	58
Microneedle-facilitated Portulaca oleracea L.-derived nanovesicles ameliorate atopic dermatitis by modulating macrophage M1/M2 polarization and inhibiting NF-κB and STING signaling pathways	58
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma	57
DNA origami nanodevice with spatial regulation of CD95 signaling for rheumatoid arthritis treatment	57
Cover Story	57
FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis	56
Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis	55
Immune organoid for cancer immunotherapy	54
Cover Story	54
Microglial APOE4 promotes neuron degeneration in Alzheimer's disease through inhibition of lipid droplet autophagy	54
Transient induction of actin cytoskeletal remodeling associated with dedifferentiation, proliferation, and redifferentiation stimulates cardiac regeneration	53
PKCα inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability	53
Spatiotemporally delivery of Cas9 ribonucleoprotein/DNAzyme logic systems using near-infrared upconversion nanomachine for precise immunotherapy	53
Emerging delivery systems based on aqueous two-phase systems: A review	53
Oral garlic-derived nanoparticles improve cancer immunotherapy	53
Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma: New opportunities towards molecularly targeted therapy	52
Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling	52
Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19	51
Precise assembly of inside-out cell membrane camouflaged nanoparticles via bioorthogonal reactions for improving drug leads capturing	51
Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis	51

DNA-PK inhibition by M3814 enhances chemosensitivity in non-small cell lung cancer	51
Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment	51
Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer	51
Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1	51
Emerging trends in organ-on-a-chip systems for drug screening	51
Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis	51
Deubiquitination complex platform: A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes	50
Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing	50
A hybrid bacterium with tumor-associated macrophage polarization for enhanced photothermal-immunotherapy	50
Table of Contents	50
Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1	50
Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants	50
Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy	50
Engineering nanomedicines for immunogenic eradication of cancer cells: Recent trends and synergistic approaches	50
MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B	50
Unveiling the metabolic fate of drugs through metabolic reaction-based molecular networking	49
Electrochemical biosensors with right-side-out-oriented cell membrane coating for the evaluation of AChE inhibitors as potential anti-Alzheimer's disease agents	49
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression	49
Harnessing the UDP-G/P2Y14R axis to promote liver regeneration in acute liver failure	49
Palmitoylated SARM1 targeting P4HA1 promotes collagen deposition and myocardial fibrosis: A new target for anti-myocardial fibrosis	49
Cover Story	49
Inhibition of CCT5-mediated asparagine biosynthesis and anti-PD-L1 produce synergistic antitumor effects in colorectal cancer	49
USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitination	49
Targeting PARylated RACK1/HIF-1α axis: A novel mechanism in acute kidney injury and therapeutic promise	48
Cover Story	48
Cover Story	48
Author correction to “PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism” [Acta Pharm Sin B 13 (2023) 157–173]	48
Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis	48
Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer	48
Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis	48
Personalized medicine of non-gene-specific chemotherapies for non-small cell lung cancer	47
Table of Contents	47
Mucosal delivery of nanovaccine strategy against COVID-19 and its variants	47
Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment	47
Author correction to ‘Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling’ [Acta Pharmaceutica Sinica B 12 (2022) 1198–	47
Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations	47
Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging	47
PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids	47
Single-domain antibodies as therapeutics for solid tumor treatment	46
Analysis of new drug registration and review in China in 2021	46
Table of Contents	46
Author correction to ‘Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo’ [Acta Pharmaceutica	45
Cover Story	45
Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib	45
mIgM-mediated splenic marginal zone B cells targeting of folic acid for immunological evasion	45
Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy	44
Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing	44
Engineered tumor specific AAV for IL-12 delivery in ovarian cancer immunotherapy	44
Identification of human LDHC4 as a potential target for anticancer drug discovery	44
The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells	44
Ferrum@albumin assembled nanoclusters inhibit NF-κB signaling pathway for NIR enhanced acute lung injury immunotherapy	44
WITHDRAWN: A neurovascular dual-targeting platelet-like bioinspired nanoplatform for ischemic stroke treatment	44
A micro-sized vaccine based on recombinant Lactiplantibacillus plantarum fights against SARS-CoV-2 infection via intranasal immunization	44
Discovery of highly potent phosphodiesterase-1 inhibitors by a combined-structure free energy perturbation approach	44
Unlocking the potential of the gut microbiome in liver regeneration: Benefits and mechanistic insights	44
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer	43
Targeting RAF dimers in RAS mutant tumors: From biology to clinic	43
Attenuated Salmonella secreting interleukin-21 activates T-cells and induces anti-tumor effects	43
Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure	43
Artificial intelligence for radiopharmaceutical and molecular imaging	42
Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls	42
Development of a novel 18F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography	42
Palmitoylation of Tfr1 enhances platelet ferroptosis and liver injury in heat stroke	42
High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation	42
Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine	41
The ubiquitin–proteasome system: A potential target for the MASLD	41
Locally producing antibacterial peptide to deplete intratumoral pathogen for preventing metastatic breast cancer	41
Translating bacteriophage-derived depolymerases into antibacterial therapeutics: Challenges and prospects	41
Application of computational methods in the drug discovery and development of Alzheimer's disease	41
Advancements and challenges in immunocytokines: A new arsenal against cancer	41
Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling	41
Targeting the coronavirus membrane protein: A promising novel therapeutic strategy	41
Cover Story	40
Next-generation clinically relevant antibody detection: Unlocking electrochemical biosensors for critical disease management	40
l-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis	40
A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance	40
Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A2A/2B receptors in tolerogenic dendritic cells	39
Target-responsive subcellular catabolism analysis for early-stage antibody–drug conjugates screening and assessment	39
Effects of small molecules on neurogenesis: Neuronal proliferation and differentiation	39
Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors	39
Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets	39
Photoimmunological hydrogel vaccine creates a supportive immune niche to promote antigen cross-presentation cascade and cancer-immunity cycle progression	39
Cover Story	38
Structures and functions of the MICOS: Pathogenesis and therapeutic implications in Alzheimer's disease	38
Artificial intelligence in drug development for delirium and Alzheimer’s disease	38
Full-profile pharmacokinetics, anticancer activity and toxicity of an extended release trivalent PEGylated irinotecan prodrug	38
Author correction to “Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metas	38
Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma	38
Development of a bacteria-nanosapper for the active delivery of ZIF-8 particles containing therapeutic genes for cancer immune therapy	38
Mucosal vaccine delivery: A focus on the breakthrough of specific barriers	38
Bile acids and coronavirus disease 2019	38
Tranexamic acid-fatty alcohol polyoxyethylene ether conjugation/PVA foam for venous sclerotherapy via vascular damage and inhibiting plasmin system	38
Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B	37
An innovative and stable mRNA-LNP microneedle vaccine elicits humoral and multifunctional cellular immune responses	37
Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection	37