Acta Pharmaceutica Sinica B

Article	Citations
Drug discovery in China: A snapshot of recent progress	1084
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	442
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	385
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	323
Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative	294
Free energy perturbation (FEP)-guided scaffold hopping	261
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	249
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	246
Reductive stress—a common metabolic feature of obesity and cancer	245
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	229
Unravelling the target landscape of tranylcypromines for new drug discovery	224
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	220
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk	219
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	204
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	201
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	200
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	198
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	196
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	190
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	189
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	184
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	163
Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii	155
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	150
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	147

A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	145
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	143
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	143
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	137
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	135
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	134
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	132
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	130
A5—A dual-target antiviral compound that rewrites the rules of influenza therapy	125
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	123
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	122
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	122
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	116
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	113
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	112
Research and development of Chinese anti-COVID-19 drugs	109
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	106
MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction	105
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	105
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	104
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	103
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy	102
Five trends of China's pharmaceutical industry in 2022	101
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma	98
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	98
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	97
Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo	96
Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge	95
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease	95
Improved prebiotic-based “shield” equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota	94
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	93
CarsiDock-Cov: A deep learning-guided approach for automated covalent docking and screening	93
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	93
Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells	92
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	92
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	91
Exemplifying interspecies variation of liposome in vivo fate by the effects of anti-PEG antibodies	91
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	88
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway	85
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	85
Deciphering the significant impact of natural glycosylation on human insulin	85
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation	85
Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway	84
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	83
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	83
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis	83
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	83
Remembering your A, B, C's: Alzheimer's disease and ABCA1	83
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	83
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy	81

Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy	80
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy	79
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	79
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	78
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease	77
Development of Chinese herbal medicine for sensorineural hearing loss	77
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	75
Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges	75
Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer	75
The role of bacteria and its derived biomaterials in cancer radiotherapy	75
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	75
Table of Contents	74
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis	74
Recent advances in developing small-molecule inhibitors against SARS-CoV-2	74
ROS-degradable polythioketal urethane scaffold for porcine wound repair	73
Metal nanoparticles for cancer therapy: Precision targeting of DNA damage	73
Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism	73
The role of botanical triterpenoids and steroids in bile acid metabolism, transport, and signaling: Pharmacological and toxicological implications	73
The epigenetic landscape of rheumatoid arthritis: Pathogenesis and drug therapeutic potentials	71
Viral miRNA-mediated activation of hyaluronan production as a drug target against COVID-19	70
Intravenous delivery of STING agonists using acid-sensitive polycationic polymer-modified lipid nanoparticles for enhanced tumor immunotherapy	70
Inhibiting collagen I production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles	69
Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy	69
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins	69
Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines	68
Recent advances in the bench-to-bedside translation of cancer nanomedicines	68
Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles	68
Synergistic metabolic modulation of fibroblast-like synoviocytes via targeted dual prodrug nanoparticles to mitigate rheumatoid arthritis	68
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins	67
Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/P	67
Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment	67
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer	66
Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo	66
Dihydromyricetin mitigates abdominal aortic aneurysm via transcriptional and post-transcriptional regulation of heme oxygenase-1 in vascular smooth muscle cells	65
Astrocyte FGF7/FGFR2 autocrine signaling mediates neuroinflammation and promotes MPTP-induced degeneration of dopaminergic neurons	64
Mitochondrial transplantation as a promising therapy for mitochondrial diseases	63
Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer	63
Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes	63
Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy	63
Recent advances to address challenges in extracellular vesicle-based applications for lung cancer	63
A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy	62
JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes	62
Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency	62
Biomimetic nanomedicines for precise atherosclerosis theranostics	62
Nanoparticles with rough surface improve the therapeutic effect of photothermal immunotherapy against melanoma	61
Tertiary lymphoid structures: The touchstone for tumor immunotherapy	61
Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives	60
Erratum to “Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis” [Acta Pharm Sin B 14 (2024) 3493–3512]	60
Advances in development of antiviral strategies against respiratory syncytial virus	60
PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism	60
Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-huma	60
Table of Contents	60
A chromosome-level Dendrobium moniliforme genome assembly reveals the regulatory mechanisms of flavonoid and carotenoid biosynthesis pathways	59
Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy	59
Microneedle-facilitated Portulaca oleracea L.-derived nanovesicles ameliorate atopic dermatitis by modulating macrophage M1/M2 polarization and inhibiting NF-κB and STING signaling pathways	59
Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect	59
Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis	59
Editor Profiles: Guest Editors of Special Column on Nanomedicines for Tumor Microenvironment Modulation	58
DNA origami nanodevice with spatial regulation of CD95 signaling for rheumatoid arthritis treatment	57
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma	57
Cover Story	57
Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1	57
Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma: New opportunities towards molecularly targeted therapy	56
FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis	56
Engineering nanomedicines for immunogenic eradication of cancer cells: Recent trends and synergistic approaches	56
Spatiotemporally delivery of Cas9 ribonucleoprotein/DNAzyme logic systems using near-infrared upconversion nanomachine for precise immunotherapy	56
Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis	55
DNA-PK inhibition by M3814 enhances chemosensitivity in non-small cell lung cancer	55
Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1	55
Microglial APOE4 promotes neuron degeneration in Alzheimer's disease through inhibition of lipid droplet autophagy	55
Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants	54
Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis	54
Oral garlic-derived nanoparticles improve cancer immunotherapy	54
Transient induction of actin cytoskeletal remodeling associated with dedifferentiation, proliferation, and redifferentiation stimulates cardiac regeneration	53
Immune organoid for cancer immunotherapy	53
Emerging delivery systems based on aqueous two-phase systems: A review	53
Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment	53
Precise assembly of inside-out cell membrane camouflaged nanoparticles via bioorthogonal reactions for improving drug leads capturing	52
PKCα inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability	52
TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor	52

Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing	52
Deubiquitination complex platform: A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes	51
Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer	51
MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B	51
Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling	50
A hybrid bacterium with tumor-associated macrophage polarization for enhanced photothermal-immunotherapy	50
Table of Contents	49
WITHDRAWN: A neurovascular dual-targeting platelet-like bioinspired nanoplatform for ischemic stroke treatment	49
Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy	49
Table of Contents	49
Identification of human LDHC4 as a potential target for anticancer drug discovery	49
Emerging trends in organ-on-a-chip systems for drug screening	49
Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19	49
Cover Story	49
Cover Story	48
Author correction to ‘Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling’ [Acta Pharmaceutica Sinica B 12 (2022) 1198–	48
Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer	48
Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy	48
Author correction to ‘Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo’ [Acta Pharmaceutica	48
Harnessing the UDP-G/P2Y14R axis to promote liver regeneration in acute liver failure	48
Analysis of new drug registration and review in China in 2021	48
Cover Story	48
Palmitoylated SARM1 targeting P4HA1 promotes collagen deposition and myocardial fibrosis: A new target for anti-myocardial fibrosis	47
High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation	47
Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging	47
Inhibition of CCT5-mediated asparagine biosynthesis and anti-PD-L1 produce synergistic antitumor effects in colorectal cancer	47
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression	47
Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling	47
USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitination	47
Artificial intelligence for radiopharmaceutical and molecular imaging	47
Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib	47
The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells	46
Targeting PARylated RACK1/HIF-1α axis: A novel mechanism in acute kidney injury and therapeutic promise	46
The ubiquitin–proteasome system: A potential target for the MASLD	46
Author correction to “PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism” [Acta Pharm Sin B 13 (2023) 157–173]	46
Electrochemical biosensors with right-side-out-oriented cell membrane coating for the evaluation of AChE inhibitors as potential anti-Alzheimer's disease agents	46
Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing	46
Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment	45
Ferrum@albumin assembled nanoclusters inhibit NF-κB signaling pathway for NIR enhanced acute lung injury immunotherapy	45
Cover Story	45
Unlocking the potential of the gut microbiome in liver regeneration: Benefits and mechanistic insights	45
Discovery of highly potent phosphodiesterase-1 inhibitors by a combined-structure free energy perturbation approach	45
Mucosal delivery of nanovaccine strategy against COVID-19 and its variants	45
Unveiling the metabolic fate of drugs through metabolic reaction-based molecular networking	45
Targeting RAF dimers in RAS mutant tumors: From biology to clinic	44
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer	44
mIgM-mediated splenic marginal zone B cells targeting of folic acid for immunological evasion	44
Development of a novel 18F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography	44
Engineered tumor specific AAV for IL-12 delivery in ovarian cancer immunotherapy	44
Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis	43
Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls	43
Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure	43
Attenuated Salmonella secreting interleukin-21 activates T-cells and induces anti-tumor effects	43
Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis	43
Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine	43
A micro-sized vaccine based on recombinant Lactiplantibacillus plantarum fights against SARS-CoV-2 infection via intranasal immunization	43
Translating bacteriophage-derived depolymerases into antibacterial therapeutics: Challenges and prospects	43
Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations	43
Personalized medicine of non-gene-specific chemotherapies for non-small cell lung cancer	43
Advancements and challenges in immunocytokines: A new arsenal against cancer	43
Locally producing antibacterial peptide to deplete intratumoral pathogen for preventing metastatic breast cancer	42
Application of computational methods in the drug discovery and development of Alzheimer's disease	42
Single-domain antibodies as therapeutics for solid tumor treatment	42
PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids	42
Cover Story	42
Targeting the coronavirus membrane protein: A promising novel therapeutic strategy	42
Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signalling	41
Development of a bacteria-nanosapper for the active delivery of ZIF-8 particles containing therapeutic genes for cancer immune therapy	41
l-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis	41
Cover Story	41
Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A2A/2B receptors in tolerogenic dendritic cells	41
Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma	41
Author correction to “Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy” [Acta Pharm Sin B (2022) 4224–4234]	41
Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer	41
A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance	40
Next-generation clinically relevant antibody detection: Unlocking electrochemical biosensors for critical disease management	40
AKR1C1 interacts with STAT3 to increase intracellular glutathione and confers resistance to oxaliplatin in colorectal cancer	40
Full-profile pharmacokinetics, anticancer activity and toxicity of an extended release trivalent PEGylated irinotecan prodrug	40
Structures and functions of the MICOS: Pathogenesis and therapeutic implications in Alzheimer's disease	39
Tranexamic acid-fatty alcohol polyoxyethylene ether conjugation/PVA foam for venous sclerotherapy via vascular damage and inhibiting plasmin system	39
Effects of small molecules on neurogenesis: Neuronal proliferation and differentiation	39
Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors	39
Artificial intelligence in drug development for delirium and Alzheimer’s disease	39
Bile acids and coronavirus disease 2019	38
“Relative symmetry with electronegativity of different key-groups” strategy for MRGPRX2 antagonist design and its effect on antigen-induced pulmonary inflammation	38
Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus	38
Author correction to “Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metas	37
Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein	37
Remodeling of the liver fibrosis microenvironment based on nilotinib-loaded multicatalytic nanozymes with boosted antifibrogenic activity	37
Alleviating experimental pulmonary hypertension via co-delivering FoxO1 stimulus and apoptosis activator to hyperproliferating pulmonary arteries	37
Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B	37
Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses	37
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis	37
Small-sized twin-nanoparticles normalize tumor vasculature to enhance tumor accumulation and penetration for potent eradication of cancer stem-like cells	37
Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy	37