Acta Pharmaceutica Sinica B

Article	Citations
Table of Contents	800
Cover Story	405
EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway	343
A retrospective cohort study of the efficacy and safety of oral azvudine versus nirmatrelvir/ritonavir in elderly hospitalized COVID-19 patients aged over 60 years	337
STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation	328
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	308
Synovial joints: The barometer of systemic inflammation	300
Cover Story	233
Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy	231
Emerging non-antibody‒drug conjugates (non-ADCs) therapeutics of toxins for cancer treatment	228
TRIM21-based degradation strategy for multimeric proteins	202
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells	201
Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as an orally active antitumor agent	200
Design consideration of phthalocyanines as sensitizers for enhanced sono-photodynamic combinatorial therapy of cancer	200
A novel biological sources consistency evaluation method reveals high level of biodiversity within wild natural medicine: A case study of Amynthas earthworms as “Guang Dilong”	192
Cover Story	191
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	186
Table of Contents	183
The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review	178
Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation	175
Small-molecule agents for cancer immunotherapy	175
Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome	174
Self-assembled multifunctional nanotheranostics against circulating tumor clusters in metastatic breast cancer	171
Peroxidase from foxtail millet bran exerts anti-colorectal cancer activity via targeting cell-surface GRP78 to inactivate STAT3 pathway	170
Guest Editors of Special Column on Drug Targets and Drug Development for Alzheimer’s Disease	167

ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells	164
Drug discovery in China: A snapshot of recent progress	159
Traditional Chinese medicine for the treatment of immune-related nephropathy: A review	157
Improving cancer immunotherapy via co-delivering checkpoint blockade and thrombospondin-1 downregulator	156
Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancy	155
Molecular glues modulate protein functions by inducing protein aggregation: A promising therapeutic strategy of small molecules for disease treatment	154
Acid-switchable nanoparticles induce self-adaptive aggregation for enhancing antitumor immunity of natural killer cells	151
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	149
Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS	145
Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning	145
Commentary: Indirect action pattern: A remote and cross-organ pharmacological mechanism for drug innovation	137
The role of E3 ubiquitin ligases in bone homeostasis and related diseases	132
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	132
Editor Profiles: Guest Editors of Special Column on A New Era of Nanobiomaterial-based Drug Delivery	130
Nano-drug delivery strategies affecting cancer-associated fibroblasts to reduce tumor metastasis	130
Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB	130
Editor Profiles: Guest Editors of Special Column on Antiviral Drug Discovery and Pharmacology	125
Editorial of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”	121
Table of Contents	121
Commentary: A nearly forgotten class of anti-inflammatory lipid molecules in central nervous system	121
Cover Story	116
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	111
The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions	109
Targeted isolation of antiviral cinnamoylphloroglucinol-terpene adducts from Cleistocalyx operculatus by building blocks-based molecular networking approach	109
Reprogramming tumor-associated macrophages and inhibiting tumor neovascularization by targeting MANF–HSF1–HSP70-1 pathway: An effective treatment for hepatocellular carcinoma	109
Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria	108
From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution	107
A reporter gene assay for determining the biological activity of therapeutic antibodies targeting TIGIT	107
Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway	106
Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2	104
Approved HIV reverse transcriptase inhibitors in the past decade	103
Research and development of Chinese anti-COVID-19 drugs	103
Construction and characterization of a humanized SLCO1B1 rat model with its application in evaluating the uptake of different statins	101
SARS-CoV-2 spike host cell surface exposure promoted by a COPI sorting inhibitor	100
SMIP-30, a potent and selective PPM1A inhibitor with potential to treat tuberculosis	99
The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer	97
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	97
APOE2 reduces risk of Alzheimer's disease by protection of lysosomes from lipid overloading	95
Neuronal activities drive brain waste clearance through the glymphatic system	92
Boosting with Omicron-specific mRNA vaccine or historical SARS-CoV-2 vaccines elicits discriminating immune responses against Omicron variants	91
Extracellular vesicles deliver thioredoxin to rescue stem cells from senescence and intervertebral disc degeneration via a feed-forward circuit of the NRF2/AP-1 composite pathway	89
Nanomaterials evoke pyroptosis boosting cancer immunotherapy	89
Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function	88
GPC3-mediated lysosome-targeting chimeras (GLTACs) for targeted degradation of membrane proteins	88
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	87
DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis	86
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	85
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	85
Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy	84
Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy	84

“Pincer movement”: Reversing cisplatin resistance based on simultaneous glutathione depletion and glutathione S-transferases inhibition by redox-responsive degradable organosilica hybrid nanoparticles	82
Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1highCD11b+ cells elimination in hepatocellular carcinoma	81
On-demand integrated nano-engager converting cold tumors to hot via increased DNA damage and dual immune checkpoint inhibition	79
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	77
TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2	76
Cover Story	76
Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability	76
siRNA micelleplexes-mediated glutamine metabolism re-engineering for vascular normalization-boosted photo-immunotherapy	76
Glutamate-releasing BEST1 channel is a new target for neuroprotection against ischemic stroke with wide time window	75
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	74
The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan	74
HR121 targeting HR2 domain in S2 subunit of spike protein can serve as a broad-spectrum SARS-CoV-2 inhibitor via intranasal administration	74
Phototriggered structures: Latest advances in biomedical applications	74
In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions	73
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy	73
Facile synthesis of insulin fusion derivatives through sortase A ligation	73
Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy	73
Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping	72
A smart O2-generating nanocarrier optimizes drug transportation comprehensively for chemotherapy improving	72
Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome	72
Reductive stress—a common metabolic feature of obesity and cancer	72
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	71
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	71
A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer	71
TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNA-PKcs cytosolic retention and DNA damage	71
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	69
Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury	69
A potentially serious adverse effect of GLP-1 receptor agonists	67
PEGylated bacteria restore intestinal mucosal barrier	67
The raphe nuclei are the early lesion site of gastric α-synuclein propagation to the substantia nigra	67
Iron and siRNA co-encapsulated ferritin nanocages induce ferroptosis synergistically for cancer therapy	66
Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9–36) in conjunction with LSN3318839	66
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	66
Dual alarmin-receptor-specific targeting peptide systems for treatment of sepsis	66
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	66
Glycan targeting nanoparticle for photodynamic immunotherapy of melanoma	65
Harnessing the cyclization strategy for new drug discovery	65
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	64
Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues	64
Intracellular aggregation of peptide-reprogrammed small molecule nanoassemblies enhances cancer chemotherapy and combinatorial immunotherapy	63
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	63
Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression	63
MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction	62
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	62
Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs	62
Cooperative coordination-mediated multi-component self-assembly of “all-in-one” nanospike theranostic nano-platform for MRI-guided synergistic therapy against breast cancer	62
Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles	61
Discovery of a potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR/P70S6K/SREBPs pathway	60
Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin III to baccatin III	60
Remodeling tumor immunosuppressive microenvironment through dual activation of immunogenic panoptosis and ferroptosis by H2S-amplified nanoformulation to enhance cancer immunotherapy	60
Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo	60
Tumor-targeted metabolic inhibitor prodrug labelled with cyanine dyes enhances immunoprevention of lung cancer	60
Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia	60
Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor‐ass	59
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	59
A redox-responsive self-assembling COA-4-arm PEG prodrug nanosystem for dual drug delivery suppresses cancer metastasis and drug resistance by downregulating hsp90 expression	59
Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma	59
Recent advances in bacterial therapeutics based on sense and response	58
Recent developments in the medicinal chemistry of single boron atom-containing compounds	58
Author correction to ‘Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA’ [Acta Pharmaceutica Sinica B 13 (2023) 2585–2600]	58
SYNCRIP controls miR-137 and striatal learning in animal models of methamphetamine abstinence	58
Author correction to ‘Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy’ [Acta Pharmaceutica Sinica B 11 (2021) 3508–3526]	57
Author correction to “Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers” [Acta Pharmaceutica Sinica B 11 (2021) 355–372]	57
Author correction to “A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer’s disease” [Acta Pharmaceutica Sinica B 12	56
A metabolic intervention strategy to break evolutionary adaptability of tumor for reinforced immunotherapy	56
An update on oral drug delivery via intestinal lymphatic transport	56
Author correction to ‘FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis’ [Acta Pharm Sin B 14 (2024) 1605–1623]	56
Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms	56
Self-assembling, pH-responsive nanoflowers for inhibiting PAD4 and neutrophil extracellular trap formation and improving the tumor immune microenvironment	56
Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges	56
Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators	56
Drug discovery by targeting the protein–protein interactions involved in autophagy	55
Environmental toxicant-induced maladaptive mitochondrial changes: A potential unifying mechanism in fatty liver disease?	55
Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization	55
Environmental exposure as a risk-modifying factor in liver diseases: Knowns and unknowns	55
Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer	54
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	54
Monoclonal antibodies and aptamers: The future therapeutics for Alzheimer's disease	54
Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii	54
Synthesis and evaluation of TSPO-targeting radioligand [18F]F-TFQC for PET neuroimaging in epileptic rats	54

Pharmaceutical applications of framework nucleic acids	53
Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder	53
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	53
ETCM v2.0: An update with comprehensive resource and rich annotations for traditional Chinese medicine	52
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk	52
Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis	52
Extracellular vesicles: Emerging tools as therapeutic agent carriers	51
Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies	51
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	50
Rhodojaponin VI indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain	50
Gains from no real PAINS: Where ‘Fair Trial Strategy’ stands in the development of multi-target ligands	50
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	50
Stimuli-responsive nano vehicle enhances cancer immunotherapy by coordinating mitochondria-targeted immunogenic cell death and PD-L1 blockade	50
Free energy perturbation (FEP)-guided scaffold hopping	50
Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders	49
Targeting the blood–brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays	49
Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression	49
Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein	49
A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models	49
Activation of PXR causes drug interactions with Paxlovid in transgenic mice	48
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit	48
CXCR6-based immunotherapy in autoimmune, cancer and inflammatory infliction	47
Natural compounds modulate the autophagy with potential implication of stroke	47
Activating Connexin43 gap junctions primes adipose tissue for therapeutic intervention	46
Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics	46
PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α–GLUT2 pathway	46
Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus	46
Repurposing carrimycin as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2	46
Microneedle-based devices for point-of-care infectious disease diagnostics	45
Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases	45
miR-429-3p mediates memory decline by targeting MKP-1 to reduce surface GluA1-containing AMPA receptors in a mouse model of Alzheimer's disease	45
Abelmoschus manihot polysaccharide fortifies intestinal mucus barrier to alleviate intestinal inflammation by modulating Akkermansia muciniphila abundance	45
Critical involvement of lysyl oxidase in seizure-induced neuronal damage through ERK-Alox5-dependent ferroptosis and its therapeutic implications	45
Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1	45
A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors	45
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	44
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS	44
Current approaches of nanomedicines in the market and various stage of clinical translation	44
Metabolomics in drug research and development: The recent advances in technologies and applications	44
Advances and challenges in the treatment of esophageal cancer	44
In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges	44
The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms	43
Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism	43
Highly sensitive H2O2-scavenging nano-bionic system for precise treatment of atherosclerosis	43
Non-canonical STING–PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response	43
Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy	43
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	43
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	43
Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases	42
Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies	42
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	42
Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles	42
Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation	42
Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways	42
Oral delivery of proteins and peptides: Challenges, status quo and future perspectives	42
Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment	41
Overcoming Mycobacterium tuberculosis through small molecule inhibitors to break down cell wall synthesis	41
Hepatic retinaldehyde deficiency is involved in diabetes deterioration by enhancing PCK1- and G6PC-mediated gluconeogenesis	41
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	41
Preclinical studies of the triazolo[1,5-a]pyrimidine derivative WS-716 as a highly potent, specific and orally active P-glycoprotein (P-gp) inhibitor	41
Orange-derived extracellular vesicles nanodrugs for efficient treatment of ovarian cancer assisted by transcytosis effect	41
Antibody–drug conjugates: Recent advances in linker chemistry	41
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	41
Editorial of Special Column on A New Era of Nanobiomaterial-based Drug Delivery	40
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	40
Thio-ProTide strategy: A novel H2S donor–drug conjugate (DDC) alleviates hepatic injury via innate lysosomal targeting	40
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	40
Enzyme-instructed and mitochondria-targeting peptide self-assembly to efficiently induce immunogenic cell death	40
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	40
Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy	40
Heterologous biosynthesis of saponin adjuvants from Quillaja saponaria: A symbolic achievement in metabolic engineering	39
Table of Contents	39
Respiratory delivered vaccines: Current status and perspectives in rational formulation design	39
Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis	39
Inhibition of intracellular proton-sensitive Ca2+-permeable TRPV3 channels protects against ischemic brain injury	38
IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα	38
Targeted inhibition of Gus-expressing Enterococcus faecalis to promote intestinal stem cell and epithelial renovation contributes to the relief of irinotecan chemotoxicity by dehydrodiisoeugenol	38
Five trends of China's pharmaceutical industry in 2022	38
HYD-PEP06 suppresses hepatocellular carcinoma metastasis, epithelial–mesenchymal transition and cancer stem cell-like properties by inhibiting PI3K/AKT and WNT/β-catenin signaling activation	37
LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase	37
Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5	37
Design, synthesis, and biological evaluation of Bcr-Abl PROTACs to overcome T315I mutation	37
3D disorganization and rearrangement of genome provide insights into pathogenesis of NAFLD by integrated Hi-C, Nanopore, and RNA sequencing	37
Molecularly engineered truncated tissue factor with therapeutic aptamers for tumor-targeted delivery and vascular infarction	37
Reactivation of PPARα alleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acid β-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy	36
Multiparametric characterization of red blood cell physiology after hypotonic dialysis based drug encapsulation process	36
Hepatic DDAH1 mitigates hepatic steatosis and insulin resistance in obese mice: Involvement of reduced S100A11 expression	36
(+)/(−)-Yanhusamides A−C, three pairs of unprecedented benzylisoquinoline-pyrrole hetero-dimeric alkaloid enantiomers from Corydalis yanhusuo	36
Fighting type 2 diabetes: Formulation strategies for peptide-based therapeutics	36
Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation: A novel approach to atherosclerosis therapy	36
Targeting macrophagic 17β-HSD7 by fenretinide for the treatment of nonalcoholic fatty liver disease	36
Functional aptamer evolution-enabled elucidation of a melanoma migration-related bioactive epitope	35
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	35
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	35
Editor Profiles: Guest Editors of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”	35