Acta Pharmaceutica Sinica B

Article	Citations
Editorial of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”	1031
Drug discovery in China: A snapshot of recent progress	478
Research and development of Chinese anti-COVID-19 drugs	432
Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii	393
MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction	372
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	309
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	286
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	245
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	240
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	238
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	236
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	231
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	224
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	215
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	212
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	211
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models	198
Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors	196
Unravelling the target landscape of tranylcypromines for new drug discovery	195
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	192
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	184
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	182
A5—A dual-target antiviral compound that rewrites the rules of influenza therapy	179
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	163
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	157

Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	154
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	153
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	145
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	142
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	142
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk	140
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	137
Reductive stress—a common metabolic feature of obesity and cancer	136
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	133
Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions	130
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	127
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	127
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	126
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy	123
Free energy perturbation (FEP)-guided scaffold hopping	121
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	117
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	116
Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues	114
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	112
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities	110
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	106
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	105
Cover Story	104
Exemplifying interspecies variation of liposome in vivo fate by the effects of anti-PEG antibodies	103
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	102
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway	102
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation	99
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	99
Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge	99
Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy	96
Improved prebiotic-based “shield” equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota	95
CarsiDock-Cov: A deep learning-guided approach for automated covalent docking and screening	94
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis	93
Development of Chinese herbal medicine for sensorineural hearing loss	91
Recent advances in developing small-molecule inhibitors against SARS-CoV-2	91
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy	90
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	89
Remembering your A, B, C's: Alzheimer's disease and ABCA1	88
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease	88
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis	87
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	87
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy	87
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	86
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	86
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	85
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	85
Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells	84
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	83
Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway	82
The role of bacteria and its derived biomaterials in cancer radiotherapy	82

Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo	82
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	82
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	80
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma	80
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	80
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease	79
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	78
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	78
Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges	77
Deciphering the significant impact of natural glycosylation on human insulin	77
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	77
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	76
Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer	76
Five trends of China's pharmaceutical industry in 2022	76
Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism	75
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy	75
Viral miRNA-mediated activation of hyaluronan production as a drug target against COVID-19	73
Dihydromyricetin mitigates abdominal aortic aneurysm via transcriptional and post-transcriptional regulation of heme oxygenase-1 in vascular smooth muscle cells	73
ROS-degradable polythioketal urethane scaffold for porcine wound repair	73
Table of Contents	73
The role of botanical triterpenoids and steroids in bile acid metabolism, transport, and signaling: Pharmacological and toxicological implications	72
Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines	72
JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes	71
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins	71
Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment	70
Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives	70
Inhibiting collagen I production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles	69
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins	69
Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer	68
A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy	68
Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo	67
Recent advances in the bench-to-bedside translation of cancer nanomedicines	66
Biomimetic nanomedicines for precise atherosclerosis theranostics	66
Metal nanoparticles for cancer therapy: Precision targeting of DNA damage	66
Synergistic metabolic modulation of fibroblast-like synoviocytes via targeted dual prodrug nanoparticles to mitigate rheumatoid arthritis	66
Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy	66
Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-huma	66
Mitochondrial transplantation as a promising therapy for mitochondrial diseases	64
Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency	64
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer	64
Recent advances to address challenges in extracellular vesicle-based applications for lung cancer	63
Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes	63
Advances in development of antiviral strategies against respiratory syncytial virus	63
The epigenetic landscape of rheumatoid arthritis: Pathogenesis and drug therapeutic potentials	63
Astrocyte FGF7/FGFR2 autocrine signaling mediates neuroinflammation and promotes MPTP-induced degeneration of dopaminergic neurons	63
Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles	62
PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism	61
Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/P	61
Nanoparticles with rough surface improve the therapeutic effect of photothermal immunotherapy against melanoma	61
Intravenous delivery of STING agonists using acid-sensitive polycationic polymer-modified lipid nanoparticles for enhanced tumor immunotherapy	60
Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy	60
Table of Contents	60
Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy	59
Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19	59
Erratum to “Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis” [Acta Pharm Sin B 14 (2024) 3493–3512]	59
Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect	59
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma	59
Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1	58
DNA origami nanodevice with spatial regulation of CD95 signaling for rheumatoid arthritis treatment	58
PKCα inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability	57
Cover Story	57
A chromosome-level Dendrobium moniliforme genome assembly reveals the regulatory mechanisms of flavonoid and carotenoid biosynthesis pathways	57
Editor Profiles: Guest Editors of Special Column on Nanomedicines for Tumor Microenvironment Modulation	56
Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis	56
Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1	56
MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B	56
FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis	55
Transient induction of actin cytoskeletal remodeling associated with dedifferentiation, proliferation, and redifferentiation stimulates cardiac regeneration	55
A hybrid bacterium with tumor-associated macrophage polarization for enhanced photothermal-immunotherapy	55
Spatiotemporally delivery of Cas9 ribonucleoprotein/DNAzyme logic systems using near-infrared upconversion nanomachine for precise immunotherapy	55
TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor	55
Immune organoid for cancer immunotherapy	55
Microglial APOE4 promotes neuron degeneration in Alzheimer's disease through inhibition of lipid droplet autophagy	54
Oral garlic-derived nanoparticles improve cancer immunotherapy	54
Emerging trends in organ-on-a-chip systems for drug screening	54
Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants	54
Deubiquitination complex platform: A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes	54
DNA-PK inhibition by M3814 enhances chemosensitivity in non-small cell lung cancer	53
Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma: New opportunities towards molecularly targeted therapy	53
Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing	52

Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling	52
Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis	52
Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment	51
Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis	51
Microneedle-facilitated Portulaca oleracea L.-derived nanovesicles ameliorate atopic dermatitis by modulating macrophage M1/M2 polarization and inhibiting NF-κB and STING signaling pathways	50
Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy	50
Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer	50
Precise assembly of inside-out cell membrane camouflaged nanoparticles via bioorthogonal reactions for improving drug leads capturing	50
Cover Story	49
Engineering nanomedicines for immunogenic eradication of cancer cells: Recent trends and synergistic approaches	49
Table of Contents	49
Emerging delivery systems based on aqueous two-phase systems: A review	49
Cover Story	49
Table of Contents	49
WITHDRAWN: A neurovascular dual-targeting platelet-like bioinspired nanoplatform for ischemic stroke treatment	48
Author correction to ‘Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling’ [Acta Pharmaceutica Sinica B 12 (2022) 1198–	48
Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy	48
Identification of human LDHC4 as a potential target for anticancer drug discovery	48
Author correction to ‘Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo’ [Acta Pharmaceutica	47
Cover Story	47
Personalized medicine of non-gene-specific chemotherapies for non-small cell lung cancer	46
Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure	46
Harnessing the UDP-G/P2Y14R axis to promote liver regeneration in acute liver failure	46
Engineered tumor specific AAV for IL-12 delivery in ovarian cancer immunotherapy	46
Unlocking the potential of the gut microbiome in liver regeneration: Benefits and mechanistic insights	46
Analysis of new drug registration and review in China in 2021	46
Mucosal delivery of nanovaccine strategy against COVID-19 and its variants	46
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer	46
Single-domain antibodies as therapeutics for solid tumor treatment	45
mIgM-mediated splenic marginal zone B cells targeting of folic acid for immunological evasion	45
Development of a novel 18F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography	45
Unveiling the metabolic fate of drugs through metabolic reaction-based molecular networking	45
Advancements and challenges in immunocytokines: A new arsenal against cancer	45
High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation	45
Targeting RAF dimers in RAS mutant tumors: From biology to clinic	45
Palmitoylated SARM1 targeting P4HA1 promotes collagen deposition and myocardial fibrosis: A new target for anti-myocardial fibrosis	45
Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer	44
A micro-sized vaccine based on recombinant Lactiplantibacillus plantarum fights against SARS-CoV-2 infection via intranasal immunization	44
Ferrum@albumin assembled nanoclusters inhibit NF-κB signaling pathway for NIR enhanced acute lung injury immunotherapy	44
Cover Story	44
Author correction to “PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism” [Acta Pharm Sin B 13 (2023) 157–173]	44
Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib	44
Discovery of highly potent phosphodiesterase-1 inhibitors by a combined-structure free energy perturbation approach	44
Inhibition of CCT5-mediated asparagine biosynthesis and anti-PD-L1 produce synergistic antitumor effects in colorectal cancer	44
USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitination	43
PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids	43
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression	43
Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling	43
Translating bacteriophage-derived depolymerases into antibacterial therapeutics: Challenges and prospects	43
The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells	42
Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-κB pathway through microbiota–gut–brain axis	42
Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing	42
Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis	42
The ubiquitin–proteasome system: A potential target for the MASLD	42
Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management	42
Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls	42
Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment	42
Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging	42
Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis	42
Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine	42
Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations	42
Locally producing antibacterial peptide to deplete intratumoral pathogen for preventing metastatic breast cancer	41
Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets	41
Next-generation clinically relevant antibody detection: Unlocking electrochemical biosensors for critical disease management	41
Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma	41
l-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis	41
Target-responsive subcellular catabolism analysis for early-stage antibody–drug conjugates screening and assessment	41
Artificial intelligence in drug development for delirium and Alzheimer’s disease	41
Targeting the coronavirus membrane protein: A promising novel therapeutic strategy	41
Cover Story	41
Application of computational methods in the drug discovery and development of Alzheimer's disease	41
Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein	41
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis	41
Author correction to “Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy” [Acta Pharm Sin B (2022) 4224–4234]	40
Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signalling	40
Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors	40
Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses	40
Development of a bacteria-nanosapper for the active delivery of ZIF-8 particles containing therapeutic genes for cancer immune therapy	40
“Relative symmetry with electronegativity of different key-groups” strategy for MRGPRX2 antagonist design and its effect on antigen-induced pulmonary inflammation	40
Cover Story	40
Tranexamic acid-fatty alcohol polyoxyethylene ether conjugation/PVA foam for venous sclerotherapy via vascular damage and inhibiting plasmin system	39
Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus	39
A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance	39
Structures and functions of the MICOS: Pathogenesis and therapeutic implications in Alzheimer's disease	39
Bile acids and coronavirus disease 2019	39
Mucosal vaccine delivery: A focus on the breakthrough of specific barriers	38
Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm	38
One-step synthesis of site-specific antibody–drug conjugates by reprograming IgG glycoengineering with LacNAc-based substrates	38
Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B	38
Small molecule-based immunomodulators for cancer therapy	37
Milk-derived exosomes exhibit versatile effects for improved oral drug delivery	37
Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection	37
Alleviating experimental pulmonary hypertension via co-delivering FoxO1 stimulus and apoptosis activator to hyperproliferating pulmonary arteries	37
Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine	37
Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer	36