Acta Pharmaceutica Sinica B

Article	Citations
Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions	1438
Decoding the chromatin accessibility in Andrographis paniculata genome, a case study of genome-wide investigation of the cis-regulatory elements in medicinal plants	476
Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies	399
Unravelling the target landscape of tranylcypromines for new drug discovery	353
Drug discovery in China: A snapshot of recent progress	310
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence	291
Table of Contents	264
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation	233
A5—A dual-target antiviral compound that rewrites the rules of influenza therapy	212
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein	206
TeroACT: A terpenoid bioactivity landscape and discovery platform	201
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis	198
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism	195
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging	178
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe	177
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities	175
Structural insights into pterocarpan reductases unveil a universal ring-opening mechanism in plant biosynthesis of 4-(furan-2-yl) phenol derivatives	175
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells	173
The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer	165
Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative	165
Oral administration of probiotic colony-like micro-nano system for immunoregulation of rheumatoid arthritis	143
Cold exposure-induced β-hydroxybutyrate promotes brown fat mitochondrial lipid droplet contact to ameliorate fatty dysfunction and hepatic steatosis	139
A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy	134
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study	131
PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy	130

Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles	130
A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants	130
The progress and perspective of nanomedicine in modulating the tumor immune microenvironment	125
Reductive stress—a common metabolic feature of obesity and cancer	122
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications	121
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke	121
Paeoniflorin alleviates hypobaric hypoxia-triggered lung injury through targeting MEK2 to modulate ERK2–SGK1 signaling	120
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors	119
Unnatural amino acid-based miniPROTACs enable efficient oncoprotein degradation	117
Development of bacterial sonosensitizer hybrid systems to enhance cancer sono-immunotherapy	117
Liver–pancreas communication in disease and drug development	116
Soft cell-derived hybrid microparticles with platelet decoys for enhanced cancer chemotherapy	113
A new approach to discovering a broad-spectrum anti-respiratory virus drug: Tubeimoside II modulates host factor PACT to potentiate the RIG-I antiviral pathway	107
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties	106
Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis	103
Distinctive molecular architectures of Gq- and Gi-coupled GLP-1 receptors	102
Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures	101
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization	101
Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia	101
Research and development of Chinese anti-COVID-19 drugs	101
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease	100
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway	100
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis	99
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer	98
Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	97
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies	96
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy	96
Deciphering the significant impact of natural glycosylation on human insulin	95
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway	94
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients	94
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo	93
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy	93
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state	92
Improved prebiotic-based “shield” equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota	91
Ferroptosis meets cancer immunotherapy: Overcoming the crosstalk challenges through advanced drug delivery strategies	90
Editor Profile: Guest Editor of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications	89
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors	89
Table of Contents	89
Engineered cyclic peptide targeting ITGA5 disrupts tumor–stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma	88
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway	88
Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption	88
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer	87
Five trends of China's pharmaceutical industry in 2022	87
Nanoparticle drug delivery system for the treatment of brain tumors: Breaching the blood–brain barrier	86
Aberrant astroglial Kir4.1 activation in the anterior cingulate cortex disrupts neuronal excitability and social behavior	85
Editor Profiles: Guest Editors of Special Column on Hot Topic Reviews in Drug (II)	85
Development of Chinese herbal medicine for sensorineural hearing loss	84
Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases	83
CarsiDock-Cov: A deep learning-guided approach for automated covalent docking and screening	83
Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis	83

Orally delivered exosome-like nanoparticles from Tetrastigma hemsleyanum Diels et Gilg remodel the gut–tumor immune axis to activate antitumor immunity	81
Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges	81
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation	81
Organoids, organ-on-a-chip, and microtumors: Biomimetic 3D tumor models advancing drug development and precision medicine	80
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy	80
High-throughput ligand discovery in living cells using the cellular protein stability enhancement assay	80
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis	79
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease	78
Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells	77
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition	76
Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptor	76
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation	76
Structural biology of HIV-1 reverse transcriptase allosteric inhibitors for drug design	75
Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS–STING pathway	74
Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer	73
Exemplifying interspecies variation of liposome in vivo fate by the effects of anti-PEG antibodies	73
The role of bacteria and its derived biomaterials in cancer radiotherapy	73
Bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy	72
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma	72
Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis	72
Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy	72
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation	71
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease	70
Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge	70
Table of Contents	69
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis	69
ROS-degradable polythioketal urethane scaffold for porcine wound repair	68
Viral miRNA-mediated activation of hyaluronan production as a drug target against COVID-19	67
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer	67
Immunocyte reprogramming empowers live-cell drug delivery: Mechanistic insights, delivery strategies, and clinical perspectives	67
CELMoD–antibody conjugates unlock a CD38 feedback loop in multiple myeloma	67
Biomimetic nitric oxide nanogenerators for synergistic gas-mild photothermal therapy of large solid tumor	66
USP10-mediated deubiquitination and activation of KRAS mutants promotes colorectal cancer via a novel USP10/KRAS positive feedback circuit	66
Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism	66
Tertiary lymphoid structures: The touchstone for tumor immunotherapy	65
Targeting non-apoptotic regulated cell death (RCD) to treat neurodegenerative diseases	65
Synergistic metabolic modulation of fibroblast-like synoviocytes via targeted dual prodrug nanoparticles to mitigate rheumatoid arthritis	64
Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/P	63
Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-huma	63
Astrocyte FGF7/FGFR2 autocrine signaling mediates neuroinflammation and promotes MPTP-induced degeneration of dopaminergic neurons	62
Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency	62
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins	61
Nanoparticles with rough surface improve the therapeutic effect of photothermal immunotherapy against melanoma	61
Dihydromyricetin mitigates abdominal aortic aneurysm via transcriptional and post-transcriptional regulation of heme oxygenase-1 in vascular smooth muscle cells	60
Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy	59
Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes	58
Metal nanoparticles for cancer therapy: Precision targeting of DNA damage	58
The role of botanical triterpenoids and steroids in bile acid metabolism, transport, and signaling: Pharmacological and toxicological implications	57
Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines	57
Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer	57
Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment	56
A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy	55
Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy	55
JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes	55
Intravenous delivery of STING agonists using acid-sensitive polycationic polymer-modified lipid nanoparticles for enhanced tumor immunotherapy	55
Biomimetic nanomedicines for precise atherosclerosis theranostics	55
Acquired pharmacoresistance in temporal lobe epilepsy is driven by Nav1.6-mediated subicular hyperexcitability	55
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins	54
PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism	54
Mitochondrial transplantation as a promising therapy for mitochondrial diseases	54
The epigenetic landscape of rheumatoid arthritis: Pathogenesis and drug therapeutic potentials	54
Recent advances in the bench-to-bedside translation of cancer nanomedicines	54
Advances in development of antiviral strategies against respiratory syncytial virus	53
Table of Contents	53
Recent advances to address challenges in extracellular vesicle-based applications for lung cancer	53
Editor Profiles: Guest Editors of Special Column on Nanomedicines for Tumor Microenvironment Modulation	53
Cover Story	52
Cover Story	52
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma	52
DNA origami nanodevice with spatial regulation of CD95 signaling for rheumatoid arthritis treatment	52
Table of Contents	52
Microneedle-facilitated Portulaca oleracea L.-derived nanovesicles ameliorate atopic dermatitis by modulating macrophage M1/M2 polarization and inhibiting NF-κB and STING signaling pathways	51
Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect	51
Deubiquitination complex platform: A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes	51
Immune organoid for cancer immunotherapy	51
Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis	50
Erratum to “Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis” [Acta Pharm Sin B 14 (2024) 3493–3512]	50
An integrated resource for ischemic heart disease defines hallmarks and heterogeneity across time and space	50
Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants	50
A chromosome-level Dendrobium moniliforme genome assembly reveals the regulatory mechanisms of flavonoid and carotenoid biosynthesis pathways	50

Cover Story	50
Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy	49
Spatiotemporally delivery of Cas9 ribonucleoprotein/DNAzyme logic systems using near-infrared upconversion nanomachine for precise immunotherapy	49
Precise assembly of inside-out cell membrane camouflaged nanoparticles via bioorthogonal reactions for improving drug leads capturing	49
Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment	49
Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19	49
Emerging trends in organ-on-a-chip systems for drug screening	48
Emerging delivery systems based on aqueous two-phase systems: A review	48
Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer	48
Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis	47
Transient induction of actin cytoskeletal remodeling associated with dedifferentiation, proliferation, and redifferentiation stimulates cardiac regeneration	47
A hybrid bacterium with tumor-associated macrophage polarization for enhanced photothermal-immunotherapy	47
Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing	47
PKCα inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability	47
Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1	47
Oral garlic-derived nanoparticles improve cancer immunotherapy	46
Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis	46
Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1	46
FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis	45
MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B	45
Microglial APOE4 promotes neuron degeneration in Alzheimer's disease through inhibition of lipid droplet autophagy	45
Gut microbiota drives the metabolic dysregulation in obesity-prone individuals by impairing GDCA-mediated activation of brown adipose thermogenesis and ileal GLP-1 secretion	45
Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy	45
Author correction to “PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism” [Acta Pharm Sin B 13 (2023) 157–173]	44
Development of a novel 18F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography	44
Engineering nanomedicines for immunogenic eradication of cancer cells: Recent trends and synergistic approaches	44
Author correction to ‘Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling’ [Acta Pharmaceutica Sinica B 12 (2022) 1198–	44
Electrochemical biosensors with right-side-out-oriented cell membrane coating for the evaluation of AChE inhibitors as potential anti-Alzheimer's disease agents	44
Cover Story	44
Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations	44
Harnessing the UDP-G/P2Y14R axis to promote liver regeneration in acute liver failure	44
Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure	43
Cover Story	43
Targeting PARylated RACK1/HIF-1α axis: A novel mechanism in acute kidney injury and therapeutic promise	43
Table of Contents	43
Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy	43
USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitination	43
Table of Contents	43
Engineered tumor specific AAV for IL-12 delivery in ovarian cancer immunotherapy	42
Microneedle-based delivery for autoimmune diseases: Emerging opportunities and unresolved questions	42
mIgM-mediated splenic marginal zone B cells targeting of folic acid for immunological evasion	42
Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer	42
Inhibition of CCT5-mediated asparagine biosynthesis and anti-PD-L1 produce synergistic antitumor effects in colorectal cancer	42
Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine	42
Interactions between the gut microbiome and ferroptosis in degenerative diseases: novel mechanisms and potential therapeutic strategies	42
Translating bacteriophage-derived depolymerases into antibacterial therapeutics: Challenges and prospects	42
Discovery of highly potent phosphodiesterase-1 inhibitors by a combined-structure free energy perturbation approach	42
Unlocking the potential of the gut microbiome in liver regeneration: Benefits and mechanistic insights	42
Identification of human LDHC4 as a potential target for anticancer drug discovery	41
A micro-sized vaccine based on recombinant Lactiplantibacillus plantarum fights against SARS-CoV-2 infection via intranasal immunization	41
Ultrasensitive bioorthogonal probes for selective discrimination of trace H2S2/H2S in sulfide-competitive contexts	41
Palmitoylation of Tfr1 enhances platelet ferroptosis and liver injury in heat stroke	41
Targeting RAF dimers in RAS mutant tumors: From biology to clinic	41
Author correction to ‘Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo’ [Acta Pharmaceutica	41
Attenuated Salmonella secreting interleukin-21 activates T-cells and induces anti-tumor effects	41
Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment	41
Mucosal delivery of nanovaccine strategy against COVID-19 and its variants	41
PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids	41
Palmitoylated SARM1 targeting P4HA1 promotes collagen deposition and myocardial fibrosis: A new target for anti-myocardial fibrosis	41
Biomimetic liposomes synergize with high-intensity focused ultrasound to induce ferroptosis in tumors	41
Single-domain antibodies as therapeutics for solid tumor treatment	40
Unveiling the metabolic fate of drugs through metabolic reaction-based molecular networking	40
The ubiquitin–proteasome system: A potential target for the MASLD	40
Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib	40
Artificial intelligence for radiopharmaceutical and molecular imaging	40
High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation	40
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer	39
Ferrum@albumin assembled nanoclusters inhibit NF-κB signaling pathway for NIR enhanced acute lung injury immunotherapy	39
Cover Story	39
Structures and functions of the MICOS: Pathogenesis and therapeutic implications in Alzheimer's disease	39
Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing	39
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression	39
Targeting the coronavirus membrane protein: A promising novel therapeutic strategy	39
Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling	39
Advancements and challenges in immunocytokines: A new arsenal against cancer	39
Loss of TET2 sulfhydration results in destabilization of TET2 and down-regulation of the immune response in melanoma	39
Tranexamic acid-fatty alcohol polyoxyethylene ether conjugation/PVA foam for venous sclerotherapy via vascular damage and inhibiting plasmin system	39
Author correction to “Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy” [Acta Pharm Sin B (2022) 4224–4234]	38
Cover Story	38
Photoimmunological hydrogel vaccine creates a supportive immune niche to promote antigen cross-presentation cascade and cancer-immunity cycle progression	38
Integrating Chinese medicine and intermittent fasting: A promising approach for treating diabetic vascular calcification	37
Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A2A/2B receptors in tolerogenic dendritic cells	37
Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus	37
Author correction to “Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metas	37
Full-profile pharmacokinetics, anticancer activity and toxicity of an extended release trivalent PEGylated irinotecan prodrug	37
Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma	37
“Relative symmetry with electronegativity of different key-groups” strategy for MRGPRX2 antagonist design and its effect on antigen-induced pulmonary inflammation	37
Alleviating experimental pulmonary hypertension via co-delivering FoxO1 stimulus and apoptosis activator to hyperproliferating pulmonary arteries	37
Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets	37
A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance	36
Application of computational methods in the drug discovery and development of Alzheimer's disease	36
Small-sized twin-nanoparticles normalize tumor vasculature to enhance tumor accumulation and penetration for potent eradication of cancer stem-like cells	36
Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein	36
Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses	36
Bile acids and coronavirus disease 2019	36