FEBS Open Bio

Article	Citations
CoCl2‐triggered pseudohypoxic stress induces proteasomal degradation of SIRT4 via polyubiquitination of lysines K78 and K299	140
A quantitative comparison of antibodies against epitope tags for immunofluorescence detection	65
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Issue Information	55
Glucose 6‐phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production	51
Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62‐dependent manner	50
An open chat with… Laszlo Nagy	45
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Real‐world genomic landscape of colon and rectal cancer	42
Retraction: IFITM3 promotes hepatocellular carcinoma invasion and metastasis by regulating MMP9 through p38/MAPK signaling	38
RETRACTION: NGF Protects Neuroblastoma Cells Against β‐Amyloid‐Induced Apoptosis via the Nrf2/HO‐1 pathway	37
Retraction statement: Luo L, Liu H and Xi Q (2018) Trastuzumab induces PUMA‐dependent apoptosis and inhibits tumor growth in gastric cancer. FEBS Open Bio 8, 1911–1919.	35
Retraction statement: Wu, H., He, Y., Chen, H., Liu, Y., Wei, B., Chen, G., Lin, H. and Lin, H. (2019), LncRNA THOR increases osteosarcoma cell stemness and migration by enhancing SOX9 mRNA stability.	35
Retraction statement: Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway	33
Retraction statement: miR‐944 inhibits metastasis of gastric cancer by preventing the epithelial–mesenchymal transition via MACC1/Met/AKT signaling	32
Upregulation of ZHX2 predicts poor prognosis and is correlated with immune infiltration in gastric cancer	30
Nitric oxide inhibits endothelial cell apoptosis by inhibiting cysteine‐dependent SOD1 monomerization	30
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RIP3‐mediated necroptosis increases neuropathic pain via microglia activation: necrostatin‐1 has therapeutic potential	27
Phosphorylation of Akt at Thr308 regulates p‐eNOS Ser1177 during physiological conditions	26
Issue Information	26
Male triploid oysters of Crassostrea gigas exhibit defects in mitosis and meiosis during early spermatogenesis	26
Development of a novel peptide inhibitor of subtilisin BPN′	25
Issue Information	25
Inhibition of miR‐93‐5p promotes osteogenic differentiation in a rabbit model of trauma‐induced osteonecrosis of the femoral head	24

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Three‐dimensional, PEG‐based hydrogels induce spheroid formation and enhance viability of A2058 melanoma cells	24
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Redefining online biology education: a study on interactive branched video utilisation and student learning experiences	23
Identification of sodium homeostasis genes in Camelus bactrianus by whole transcriptome sequencing	23
Potential radiosensitive germline biomarkers in the testes of wild mice after the Fukushima accident	22
FEBS fellowships: supporting excellent science for over four decades	22
Issue Information	22
Withdrawn: MicroRNA‐142‐5p inhibits autophagy in cardiomyocytes in a mouse model of hypoxia/reoxygenation	21
Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation	21
Retraction statement: MicroRNA‐431 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the ZEB1‐mediated epithelial–mesenchymal transition	21
Cpeb1 expression is post‐transcriptionally regulated by AUF1, CPEB1, and microRNAs	20
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Structural and functional characterization of a plant alpha‐actinin	20
CXCR4 promotes gefitinib resistance of Huh7 cells by activating the c‐Met signaling pathway	20
Targeted recombination of homologous chromosomes using CRISPR‐Cas9	19
Disordered testosterone transport in mice lacking the ganglioside GM2/GD2 synthase gene	19
Accumulation of amyloid beta (Aβ) and amyloid precursor protein (APP) in tumors formed by a mouse xenograft model of inflammatory breast cancer	19
Issue Information	18
Actin‐related protein 5 suppresses the cooperative activation of cardiac gene transcription by myocardin and MEF2	18
A redox‐active HybG‐HypD scaffold complex is required for optimal ATPase activity during [NiFe]‐hydrogenase maturation in Escherichia coli	18
Mechanism of imidazole inhibition of a GH1 β‐glucosidase	18
Integrative investigation of the TF–miRNA coregulatory network involved in the inhibition of breast cancer cell proliferation by resveratrol	18
Learning objectives: an epiphany	17
Relationship between anticancer sensitivities and cellular respiration properties in 5‐fluorouracil‐resistant HCT116 human colorectal cancer cells	17
Complement C5a‐triggered differentiated HL‐60 stimulates migration of THP‐1 monocytic leukocytes via secretion of CCL2	16
Membraneless organelles: a smart design for metabolic control	16
Inhibition of p53 and ATRX increases telomeric recombination in primary fibroblasts	16
Reviving lost binding sites: Exploring calcium‐binding site transitions between human and murine CD23	16
Chrysin 7‐O‐β‐d‐glucopyranoside increases hepatic low‐density lipoprotein receptor expression through AMP‐activated protein kinase activation	16
Comprehensive optimization of a reporter assay toolbox for three distinct CRISPR‐Cas systems	16
Pulmonary ACE2 expression in neonatal and adult rats	15
Lewis fucose is a key moiety for the recognition of histo‐blood group antigens by GI.9 norovirus, as revealed by structural analysis	15
Talks	15
Issue Information	15
Genomic analysis of Neisseria elongata isolate from a patient with infective endocarditis	15
Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21	15
Tyr76 is essential for the cold adaptation of a class II glutaredoxin 4 with a heat‐labile structure from the Arctic bacteriumSphingomonassp.	15
Prognostic significance of the rhoGTPase RHOVand its role in tumor immune cell infiltration: a comprehensive pan‐cancer analysis	14
The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions	14
New regulators of the tetracycline‐inducible gene expression system identified by chemical and genetic screens	14
Haemophilus influenzae Protein D antibody suppression in a multi‐component vaccine formulation	14
A mouse model of lung cancer induced via intranasal injection for anticancer drug screening and evaluation of pathology	14
Dexamethasone induces p21cip1/waf1 expression via FoxO3a independently of the Lamin A/C‐HDAC2 interaction in Ataxia Telangiectasia	14
Establishment and characterization of a primary cell culture derived from external auditory canal squamous cell carcinoma	13
Toll‐like receptor 9 signaling in chronic lymphocytic leukemia cell lines	13
Identification and characterization of a novel glutaminase inhibitor	13
CCR7 and its related molecules may be potential biomarkers of pulmonary arterial hypertension	13
SNRPC promotes hepatocellular carcinoma cell motility by inducing epithelial‐mesenchymal transition	13

UbiN, a novel Rhodobacter capsulatus decarboxylative hydroxylase involved in aerobic ubiquinone biosynthesis	13
Characterisation of a common hotspot variant in acute intermittent porphyria sheds light on the mechanism of hydroxymethylbilane synthase function	12
Issue Information	12
Comparative transcriptomics of the Djungarian hamster hypothalamus during short photoperiod acclimation and spontaneous torpor	12
Deletion of gmfA induces keratocyte‐like migration inDictyostelium	12
Membrane‐acting biomimetic peptoids against visceral leishmaniasis	12
RAB31 in glioma‐derived endothelial cells promotes glioma cell invasion via extracellular vesicle‐mediated enrichment of MYO1C	12
Molecular dynamics provides new insights into the mechanism of calcium signal transduction and interdomain interactions in cardiac troponin	12
Proximity‐dependent biotinylation reveals an interaction between ubiquitin‐specific peptidase 46 and centrosome‐related proteins	11
Making teamwork work: enhancing teamwork and assessment in higher education	11
Chorein deficiency promotes ferroptosis	11
Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers	11
Interaction of RECQL4 with poly(ADP‐ribose) is critical for the DNA double‐strand break response in human cells	11
Anti‐inflammatory properties of ophioglonin derived from the fern Ophioglossum vulgatum L. via inactivating NF‐κB and MAPK signaling pathways	11
E2F1 promotes cell migration in hepatocellular carcinoma via FNDC3B	11
CDK5 interacts with MST2 and modulates the Hippo signalling pathway	11
Issue Information	10
Urinary SPP1 has potential as a non‐invasive diagnostic marker for focal segmental glomerulosclerosis	10
Inhibition of PRMT1 alleviates sepsis‐induced acute kidney injury in mice by blocking the TGF‐β1 and IL‐6 trans‐signaling pathways	10
Identification of two methylated fragments of an SDC2 CpG island using a sliding window technique for early detection of colorectal cancer	10
Structural enzymology studies with the substrate 3S‐hydroxybutanoyl‐CoA: bifunctional MFE1 is a less efficient dehydrogenase than monofunctional HAD	10
Posters Annex	10
Single‐cell transcriptome analysis of male chicken germ cells reveals changes in signaling pathway‐related gene expression profiles during mitotic arrest	10
Ets family proteins regulate the EMT transcription factors Snail and ZEB in cancer cells	10
The beginning and the end of SNARE‐induced membrane fusion	10
Overexpression of cyclin‐dependent kinase 1 in esophageal squamous cell carcinoma and its clinical significance	10
Talks	10
Cost‐effective and simple flow cytometry quantification of receptor‐mediated autophagy using fluorescent tagging	10
Analgesic effects of nerve growth factor‐directed monoclonal antibody on diabetic neuralgia in an animal model	10
Guaiazulene derivative 1,2,3,4‐tetrahydroazuleno[1,2‐b] tropone reduces the production of ATP by inhibiting electron transfer complex II	10
Reduced TREM2 activation in microglia of patients with Alzheimer's disease	10
The durability of resin–dentine bonds are enhanced by epigallocatechin‐3‐gallate‐encapsulated nanohydroxyapatite/mesoporous silica	9
Transcriptional changes impact hepatic proteome in autophagy‐impaired liver	9
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Dysbiosis of gut microbiota after cholecystectomy is associated with non‐alcoholic fatty liver disease in mice	9
N6‐methyladenosine (m6A) RNA modification of G protein‐coupled receptor 133 increases proliferation of lung adenocarcinoma	9
Optogenetic control of early embryos labeling using photoactivatable Cre recombinase 3.0	9
Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer	9
Bone marrow mesenchymal stem cell‐derived extracellular vesicles promote corneal epithelial repair and suppress apoptosis via modulation of Caspase‐3 in vitro	9
Characterization of the complete chloroplast genome of Rhodiola sachalinensis and comparative analysis with its congeneric plants	9
c‐Abl kinase regulates cell proliferation and ionizing radiation‐induced G2/M arrest via phosphorylation of FHL2	9
SREBP1/FASN/cholesterol axis facilitates radioresistance in colorectal cancer	8
The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme?	8
Immune‐related matrisomes are potential biomarkers to predict the prognosis and immune microenvironment of glioma patients	8
Mutations in RPS19 may affect ribosome function and biogenesis in Diamond Blackfan anemia	8
RETRACTION: XBP1 Inhibits Mesangial Cell Apoptosis in Response to Oxidative Stress via the PTEN/AKT Pathway in Diabetic Nephropathy	8
The relationship between depletion of brain GM1 ganglioside and Parkinson's disease	8
Antitubercular potential and pH‐driven mode of action of salicylic acid derivatives	8
Large‐scale analysis of the genome of the rare alkaline‐halophilic Stachybotrys microspora reveals 46 cellulase genes	8
Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages	8
Teaching, research or balanced? An exploration of the experiences of biomedical scientists working in UK medical schools	8
Expansion Microscopy‐based imaging for visualization of mitochondria in Drosophila ovarian germline stem cells	8
An enzyme‐linked immunosorbent assay (ELISA)‐based activity assay for AMP‐activated protein kinase (AMPK)	8
2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione mediates the effect of ROS‐enhanced PI3K/Akt/mTOR pathway on autophagy in breast cancer	8
Regorafenib as a potential drug for severe COVID‐19: inhibition of inflammasome activation in mice	8
Thermodynamic analysis of the interactions between human ACE2 and spike RBD of Betacoronaviruses (SARS‐CoV‐1 and SARS‐CoV‐2)	8
Correction	8
Downregulation of SUMO2 inhibits hepatocellular carcinoma cell proliferation, migration and invasion	8
GPR35‐mediated kynurenic acid sensing contributes to maintenance of gut microbiota homeostasis in ulcerative colitis	8
PRMT1‐mediated arginine methylation promotes YAP activation and hepatocellular carcinoma proliferation	8
Characterization of two bacterial tyrosinases from the halophilic bacterium Hahella sp. CCB MM4 relevant for phenolic compounds oxidation in wetlands	8
RETRACTION: LKB1 Suppresses Androgen Synthesis in a Mouse Model of Hyperandrogenism via IGF‐1 Signaling	8
Structural analysis of an Asterias rubens peptide indicates the presence of a disulfide‐directed β‐hairpin fold	8
Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus	8
Professor Stuart John Ferguson (29 September 1949–25 April 2024)	8
Retraction statement: Ding, J., Wang, X., Gao, J. and Song, T. (2021), Silencing of cystatin SN abrogates cancer progression and stem cell properties in papillary thyroid carcinoma. FEBS Open Bio, 11:	8
Biogenesis of mitochondrial β‐barrel membrane proteins	7
Active biopackaging produced from by‐products and waste from food and marine industries	7
Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration	7
Cadherin‐6 is a novel mediator for the migration of mesenchymal stem cells to glioblastoma cells in response to stromal cell‐derived factor‐1	7
HIF2α‐induced upregulation of RNASET2 promotes triglyceride synthesis and enhances cell migration in clear cell renal cell carcinoma	7
N6‐isopentenyladenosine inhibits aerobic glycolysis in glioblastoma cells by targeting PKM2 expression and activity	7
Structural and functional insights into lysine acetylation of cytochrome c using mimetic point mutants	7
Biochemical characterization of a novel oxidatively stable, halotolerant, and high‐alkaline subtilisin from Alkalihalobacillus okhensisKh10‐101T	7
A brief overview of BNIP3L/NIX receptor‐mediated mitophagy	7
Carbohydrate response element‐binding protein (ChREBP) mediates decreased SNAP25 expression in islets from diabetic Goto‐Kakizaki (GK) rats	7
A curcumin analogue GO‐Y030 depletes cancer stem cells by inhibiting the interaction between the HSP70/HSP40 complex and its substrates	7
Integrative analysis of immune‐related signature profiles in eosinophilic chronic rhinosinusitis with nasal polyposis	7
4,5,7‐Trisubstituted indeno[1,2‐b]indole inhibits CK2 activity in tumor cells equivalent to CX‐4945 and shows strong anti‐migratory effects	7
Store‐operated calcium entry mediates hyperalgesic responses during neuropathy	7

CCR4‐IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T‐cell lymphoma in a mouse CTCL model	7
Intracellular protein crystallization in living insect cells	7
Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR–p70S6K pathway	6
Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate	6
Synergistic antibacterial activity of baicalin in combination with oxacillin sodium against methicillin‐resistant Staphylococcus aureus	6
SV40 T antigen helicase domain regions responsible for oligomerisation regulate Okazaki fragment synthesis initiation	6
Knockdown of TMEM160 leads to an increase in reactive oxygen species generation and the induction of the mitochondrial unfolded protein response	6
Development and validation of a four‐lipid metabolism gene signature for diagnosis of pancreatic cancer	6
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Liraglutide enhances the effect of checkpoint blockade in lung and liver cancers through the inhibition of neutrophil extracellular traps	6
Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones	6
The spike glycoprotein of highly pathogenic human coronaviruses: structural insights for understanding infection, evolution and inhibition	6
Identification of novel meQTLs strongly associated with rheumatoid arthritis by large‐scale epigenome‐wide analysis	6
Serum metabolomics detected by LDI‐TOF‐MS can be used to distinguish between diabetic patients with and without diabetic kidney disease	6
Characterization and comparison of recombinant full‐length ursine and human sex hormone‐binding globulin	6
The dynamics of cell death patterns and regeneration during acute liver injury in mice	6
Machine learning‐mediated identification of ferroptosis‐related genes in osteonecrosis of the femoral head	6
Regulation of cardiac fibrosis in mice with TAC/DOCA‐induced HFpEF by resistin‐like molecule gamma and adenylate cyclase 1	6
Transfer of stabilising mutations between different secondary active transporter families	6
Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria	6
Isoflurane induces Art2‐Rsp5‐dependent endocytosis of Bap2 in yeast	6
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Multiple interaction modes between saccharin and sweet taste receptors determine a species‐dependent response to saccharin	6
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Tim‐3 suppresses autoimmune hepatitis via the p38/MKP‐1 pathway in Th17 cells	6
Characterization of the preferred cation cofactors of chloroplast protein kinases in Arabidopsis thaliana	6
Development of a variant of dinutuximab with enhanced antitumor efficacy and reduced induction of neuropathic pain	6
Is allostery a fuzzy concept?	6
DDR2 signaling and mechanosensing orchestrate neuroblastoma cell fate through different transcriptome mechanisms	6
Signature reversion of three disease‐associated gene signatures prioritizes cancer drug repurposing candidates	6
Overexpression of TRAF4 promotes lung cancer growth and EGFR‐dependent phosphorylation of ERK5	5
Identification of differentially expressed genes in diabetic kidney disease by RNA‐Seq analysis of venous blood platelets	5
Design of an epitope‐based peptide vaccine against Cryptococcus neoformans	5
Evolution of memory system‐related genes	5
Prognostic biomarker identification and tumor classification in breast cancer patients by methylation and transcriptome analysis	5
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Nanoparticles of folic acid‐methyl‐β‐cyclodextrin (FA‐MβCD)/adamantane‐albumin exhibit enhanced antitumor activity compared with FA‐MβCD alone	5
Structural investigations of proteins encoded by SARS‐CoV‐2	5
Zebrafish and medaka T1R (taste receptor type 1) proteins mediate highly sensitive recognition of l‐proline	5
Dkk1 inhibits malignant transformation induced by Bmi1 via the β‐catenin signaling axis in WB‐F344 oval cells	5
Cytotoxicity by endocrine disruptors through effects on ER Ca2+ transporters, aberrations in Ca2+ signalling pathways and ER stress	5
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Screening and characterization of aptamers recognizing the periodontal pathogen Tannerella forsythia	5
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Potentially reduced fusogenicity of syncytin‐2 in New World monkeys	5
GRK5‐mediated inflammation and fibrosis exert cardioprotective effects during the acute phase of myocardial infarction	5
Destabilization of vitelline membrane outer layer protein 1 homolog (VMO1) by C‐mannosylation	5
Cantharidin downregulates PSD1 expression and inhibits autophagic flux in yeast cells	5
Fibroblast growth factor 2 acts as an upstream regulator of inhibition of pulmonary fibroblast activation	5
Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities	5
Understanding and measuring mechanical signals in the tumor stroma	5
Phenotypical and biochemical characterization of murine psoriasiform and fibrotic skin disease models in Stabilin‐deficient mice	5
YAP‐TEAD inhibition is associated with upregulation of an androgen receptor mediated transcription program providing therapeutic escape	5
ERCC5, HES6 and RORA are potential diagnostic markers of coronary artery disease	5
PAPP‐A functions as a tumor suppressor and is downregulated in renal cell carcinoma	5
Issue Information	5
Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation	5
Expression of a triple mutational des‐pGlu brazzein in transgenic mouse milk	5
Small ankyrin 1 (sANK1) promotes docetaxel resistance in castration‐resistant prostate cancer cells by enhancing oxidative phosphorylation	5
Myoblast‐derived exosomes promote the repair and regeneration of injured skeletal muscle in mice	5
Withdrawal: Urinary exosomal tRNA‐derived small RNA signatures as a predictive biomarker in lung cancer	5
Dysfunction of Drosophila mitochondrial carrier homolog (Mtch) alters apoptosis and disturbs development	5
The role of cytidine 5′‐triphosphate synthetase 1 in metabolic rewiring during epithelial‐to‐mesenchymal transition in non‐small‐cell lung cancer	5
Seasonal UV exposure and vitamin D: association with the dynamics of COVID‐19 transmission in Europe	5
Development and single‐particle analysis of hybrid extracellular vesicles fused with liposomes using viral fusogenic proteins	4
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Front Cover	4
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Biochemical characterization and gene structure analysis of the 24‐kDa glutathione transferase sigma from Taenia solium	4
Cabazitaxel suppresses colorectal cancer cell growth via enhancing the p53 antitumor pathway	4
AMP‐dependent kinase stimulates the expression of αKlotho	4
The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids	4
Thymus capitatus flavonoids inhibit infection of Kaposi's sarcoma‐associated herpesvirus	4
ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation	4
Novel circular RNAs of the apoptosis‐related BAX and BCL2L12 genes identified in a chronic lymphocytic leukemia cell line using nanopore sequencing	4
Protective effects of resveratrol on the ethanol‐induced disruption of retinogenesis in pluripotent stem cell‐derived organoids	4
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Issue Information	4
Issue Information	4
The miR‐223/nuclear factor I‐A axis regulates inflammation and cellular functions in intestinal tissues with necrotizing enterocolitis	4
Crystal structure of a novel homodimeric l‐ribulose 3‐epimerase from Methylomonus sp.	4
Periplasmic binding proteins Bug69 and Bug27 from Bordetella pertussis are in vitro high‐affinity quinolinate binders with a potential role in NAD biosynthesis	4
Halogenated boroxine increases propensity to apoptosis in leukemia (UT‐7) but not non‐tumor cells in vitro	4
Posters	4
Issue Information	4
Frequency, topic, and preferences: Tracking student engagement with several modalities of student–instructor contact in a first‐year course	4
Talks	4
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Follicle‐stimulating hormone worsens osteoarthritis by causing inflammation and chondrocyte dedifferentiation	4
Issue Information	4
Acquired and intrinsic resistance to vemurafenib in BRAFV600E‐driven melanoma brain metastases	4
Biological and clinical implications of metastasis‐associated circular RNAs in oesophageal squamous cell carcinoma	4
Metabolic reprogramming heterogeneity in chronic kidney disease	4
Endothelial cell‐derived extracellular vesicles induce pro‐angiogenic responses in mesenchymal stem cells	4
Establishment of immortalized Egyptian Rousettus bat cell lines	4