Molecular Metabolism

Article	Citations
Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity	874
Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis	360
Editorial Board, cover figure description and credits	247
10 years of Molecular Metabolism	209
Editorial Board, cover figure description and credits	208
Editorial Board, cover figure description and credits	195
Pancreatic beta-cell specific BAG3 knockout results in chronic hyperinsulinemia inducing insulin resistance	194
Editorial Board, cover figure description and credits	192
Timing of exercise differentially impacts adipose tissue gain in male adolescent rats	176
Corrigendum to “Timing of exercise differentially impacts adipose tissue gain in male adolescent rats” [Mol Metabol 93 (2025) 102100, 1–14]	149
Nutrient control of splice site selection contributes to methionine addiction of cancer	139
Pre-operative DNA methylation marks as predictors of weight loss outcomes after sleeve gastrectomy	139
Hypoxia-inducible factor 1α is required to establish the larval glycolytic program in Drosophila melanogaster	138
Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body	137
Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in pathological eating behavior	134
High fructose rewires gut glucose sensing via glucagon-like peptide 2 to impair metabolic regulation in mice	134
ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance	133
GLIS3: A novel transcriptional regulator of mitochondrial functions and metabolic reprogramming in postnatal kidney and polycystic kidney disease	120
Atlas of exercise-induced brain activation in mice	110
Histone H3K9 butyrylation is regulated by dietary fat and stress via an Acyl-CoA dehydrogenase short chain-dependent mechanism	109
Imaging biomarkers of NAFLD, NASH, and fibrosis	99
Non-alcoholic fatty liver disease and steatohepatitis: State of the art on effective therapeutics based on the gold standard method for diagnosis	83
Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation	80
Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism	79
Single-cell chromatin accessibility of developing murine pancreas identifies cell state-specific gene regulatory programs	79

BBSome ablation in SF1 neurons causes obesity without comorbidities	78
Contribution of the co-chaperone FKBP51 in the ventromedial hypothalamus to metabolic homeostasis in male and female mice	78
Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells	78
Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states	76
The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1α inhibition	70
Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells	66
Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling	66
The miR-200–Zeb1 axis regulates key aspects of β-cell function and survival in vivo	63
Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions	63
Multicompartmental non-invasive sensing of postprandial lipemia in humans with multispectral optoacoustic tomography	63
The transcriptional co-regulator LDB1 is required for brown adipose function	62
Physiological impact of in vivo stable isotope tracing on cancer metabolism	60
An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation	57
Novel noncoding RNA CircPTK2 regulates lipolysis and adipogenesis in cachexia	57
Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice	56
Structural principles of insulin formulation and analog design: A century of innovation	55
High fat / high cholesterol diet does not provoke atherosclerosis in the ω3-and ω6-polyunsaturated fatty acid synthesis–inactivated Δ6-fatty acid desaturase–deficient mouse	53
The effects of housing density on mouse thermal physiology depend on sex and ambient temperature	52
Proteomic quantitative study of dorsal root ganglia and sciatic nerve in type 2 diabetic mice	52
Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes	50
Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation	50
Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation	49
Insulin resistance per se drives early and reversible dysbiosis-mediated gut barrier impairment and bactericidal dysfunction	48
Neuronal miR-29a protects from obesity in adult mice	48
The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition	48
Neurons undergo pathogenic metabolic reprogramming in models of familial ALS	48
Dysregulated systemic metabolism in a Down syndrome mouse model	47
Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer	47
Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release	47
FoxK1 associated gene regulatory network in hepatic insulin action and its relationship to FoxO1 and insulin receptor mediated transcriptional regulation	46
Basal re-esterification finetunes mitochondrial fatty acid utilization	46
GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity	46
Hepatic follistatin increases basal metabolic rate and attenuates diet-induced obesity during hepatic insulin resistance	46
Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib	45
Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice	44
Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2	44
Exploring the role of purinergic receptor P2RY1 in type 2 diabetes risk and pathophysiology: Insights from human functional genomics	43
Deletion of Ascl1 in pancreatic β-cells improves insulin secretion, promotes parasympathetic innervation, and attenuates dedifferentiation during metabolic stress	43
Hepatic regulator of G protein signaling 14 ameliorates NAFLD through activating cAMP-AMPK signaling by targeting Giα1/3	42
Scd1 and monounsaturated lipids are required for autophagy and survival of adipocytes	42
All–potassium channel CRISPR screening reveals a lysine-specific pathway of insulin secretion	42
The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake	41
Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline	41
Renal L-2-hydroxyglutarate dehydrogenase activity promotes hypoxia tolerance and mitochondrial metabolism in Drosophila melanogaster	40
Uncoupling protein 1-driven Cre (Ucp1-Cre) is expressed in the epithelial cells of mammary glands and various non-adipose tissues	40
An efficient AAV vector system of Rec2 serotype for intravenous injection to study metabolism in brown adipocytes in vivo	40
Tanycytes release glucose using the glucose-6-phosphatase system during hypoglycemia to control hypothalamic energy balance	40
Glucose-1,6-bisphosphate: A new gatekeeper of cerebral mitochondrial pyruvate uptake	39
The role of intestinal microbiota in physiologic and body compositional changes that accompany CLA-mediated weight loss in obese mice	39
Macrophages on the run: Exercise balances macrophage polarization for improved health	38

Maternal gut Bifidobacterium breve modifies fetal brain metabolism in germ-free mice	38
Distinct genetic signals at the FGF21 locus complicate studies of FGF21's role in diet regulation using human cohort data	38
TGF-β antagonism synergizes with PPARγ agonism to reduce fibrosis and enhance beige adipogenesis	38
Thyroid hormone receptor beta (THRβ1) is the major regulator of T3 action in human iPSC-derived hepatocytes	38
Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD)	37
Corrigendum to ‘ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation’ [Molecular Metabolism 25 (2019) p.83–94]	36
Single nuclei RNA sequencing of the rat AP and NTS following GDF15 treatment	35
Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice	35
L-cell Arntl is required for rhythmic glucagon-like peptide-1 secretion and maintenance of intestinal homeostasis	35
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction	35
Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation	34
Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis	34
Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD	34
Sodium-glucose co-transporter2 expression and inflammatory activity in diabetic atherosclerotic plaques: Effects of sodium-glucose co-transporter2 inhibitor treatment	33
Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetes	33
Noncoding RNAs from tissue-derived small extracellular vesicles: Roles in diabetes and diabetic complications	33
Stress kinases in the development of liver steatosis and hepatocellular carcinoma	33
Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1	32
The gut–brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders	32
Reprogramming hormone-sensitive prostate cancer to a lethal neuroendocrine cancer lineage by mitochondrial pyruvate carrier (MPC)	31
Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity	31
Update on the effects of energy metabolism in bone marrow mesenchymal stem cells differentiation	31
Deletion of the mitochondrial calcium uniporter in adipose tissue promotes energy expenditure and alleviates diet-induced obesity	30
Genome-wide meta-analysis of 92 cardiometabolic protein serum levels	30
High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease	30
Beta-hydroxybutyrate dampens adipose progenitors’ profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36-dependent mechanisms	30
Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity	29
Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle	29
CRISPR knockdown of Kcnq3 attenuates the M-current and increases excitability of NPY/AgRP neurons to alter energy balance	29
Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model	28
Corrigendum to “Results from three phase 1 trials of NNC9204-1177, a glucagon/GLP-1 receptor co-agonist: effects on weight loss and safety in adults with overweight or obesity” [Mol Metab 78 (2023) 10	28
Corrigendum to “Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis” [Mol Metab. 70 (2023) 101698]∗	28
Lipocalin-2 promotes adipose–macrophage interactions to shape peripheral and central inflammatory responses in experimental autoimmune encephalomyelitis	28
WITHDRAWN: SGLT2i reduces renal injury by improving mitochondrial metabolism and biogenesis	28
mTORC1 is required for epigenetic silencing during β-cell functional maturation	28
Corrigendum to “Lack of Gαi2 proteins in adipocytes attenuates diet-induced obesity” [Mol Metab 40 (2020 Oct) 101029]	28
Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis	27
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction	27
Nutrient-sensing growth hormone secretagogue receptor in macrophage programming and meta-inflammation	27
Adipose knockout of H-ferritin improves energy metabolism in mice	27
Dietary medium-chain fatty acids reduce food intake via the GDF15-GFRAL axis in mice	27
Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis	27
Gene-based whole genome sequencing meta-analysis of 250 circulating proteins in three isolated European populations	26
Deletion of Six3 in post-proliferative neurons produces weakened SCN circadian output, improved metabolic function, and dwarfism in male mice	26
Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis	26
C/EBPβ-LIP mediated activation of the malate-aspartate shuttle sensitizes cells to glycolysis inhibition	26
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity	26
Median eminence myelin continuously turns over in adult mice	25
Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL)	25
A novel lncRNA RP11-386G11.10 reprograms lipid metabolism to promote hepatocellular carcinoma progression	25
Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk	25
Metabolic drivers of non-alcoholic fatty liver disease	25
Lcn2 mediates adipocyte-muscle-tumor communication and hypothermia in pancreatic cancer cachexia	25
Resistance exercise enhances long-term mTORC1 sensitivity to leucine	25
Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis	25
Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes	24
Glucose intolerance as a consequence of hematopoietic stem cell dysfunction in offspring of obese mice	24
Endothelial TrkA coordinates vascularization and innervation in thermogenic adipose tissue and can be targeted to control metabolism	24
Mammalian D-Cysteine controls insulin secretion in the pancreas	24
Distinct roles for the domains of the mitochondrial aspartate/glutamate carrier citrin in organellar localization and substrate transport	24
A novel fatty acid mimetic with pan-PPAR partial agonist activity inhibits diet-induced obesity and metabolic dysfunction-associated steatotic liver disease	23
Ube2i deletion in adipocytes causes lipoatrophy in mice	23
Diabetes increases mortality in patients with pancreatic and colorectal cancer by promoting cachexia and its associated inflammatory status	23
Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice	23
Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity	23
Chronic inflammation and the hallmarks of aging	23
Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation	22
Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-κB signaling pathway	22
Microbiota and body weight control: Weight watchers within?	22
Daily running enhances molecular and physiological circadian rhythms in skeletal muscle	22
The SARS-CoV-2 spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice	22
Dynamic changes in β-cell [Ca2+] regulate NFAT activation, gene transcription, and islet gap junction communication	22
DNA damage to β cells in culture recapitulates features of senescent β cells that accumulate in type 1 diabetes	22
Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females	22
Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle	22
Toward modeling metabolic state from single-cell transcriptomics	22
Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression	22
A Once-Daily GLP-1/GIP/Glucagon Receptor Tri-agonist (NN1706) Lowers Body Weight in Rodents, Monkeys and Humans	22
HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis	22
PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation	21

Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems	21
Bioenergetic adaptations of small intestinal epithelial cells reduce cell differentiation enhancing intestinal permeability in obese mice	21
Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice	21
Advances in the treatment of metabolic diseases	21
Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease	21
Single-agent FOXO1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice	21
Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo	21
Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP	21
Pharmacological inhibition of ALCAT1 mitigates amyotrophic lateral sclerosis by attenuating SOD1 protein aggregation	21
Editorial Board, cover figure description and credits	21
The bioenergetic landscape of cancer	21
Stem cell-based multi-tissue platforms to model human autoimmune diabetes	21
Glycolysis maintains AMPK activation in sorafenib-induced Warburg effect	21
Transcriptomic signatures of cold acclimated adipocytes reveal CXCL12 as a Brown autocrine and paracrine chemokine	21
Disruption of adipocyte YAP improves glucose homeostasis in mice and decreases adipose tissue fibrosis	21
Editorial Board, cover figure description and credits	21
Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production	20
Elevation of hypothalamic ketone bodies induces a decrease in energy expenditures and an increase risk of metabolic disorder	20
PET imaging of sodium-glucose cotransporters (SGLTs): Unveiling metabolic dynamics in diabetes and oncology	20
Loss of mitochondria long-chain fatty acid oxidation impairs skeletal muscle contractility by disrupting myofibril structure and calcium homeostasis	20
Dietary protein defends lean mass and maintains the metabolic benefits of glucagon receptor agonism in mice	20
Improvement of MASLD and MASH by suppression of hepatic N-acetyltransferase 10	20
TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis	19
Inceptor correlates with markers of prostate cancer progression and modulates insulin/IGF1 signaling and cancer cell migration	19
Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion	19
Editorial Board, cover figure description and credits	19
Modulation of stress-related behaviour by preproglucagon neurons and hypothalamic projections to the nucleus of the solitary tract	19
Programming of cardiac metabolism by miR-15b-5p, a miRNA released in cardiac extracellular vesicles following ischemia-reperfusion injury	19
Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus	19
Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP neurons	19
Gsα-dependent signaling is required for postnatal establishment of a functional β-cell mass	19
Editorial Board, cover figure description and credits	19
ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol/PPAR signaling in obese mice	19
Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells	18
Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis	18
Type 2 diabetes subgroups and potential medication strategies in relation to effects on insulin resistance and beta-cell function: A step toward personalised diabetes treatment?	18
Editorial Board, cover figure description and credits	18
Rest phase snacking increases energy resorption and weight gain in male mice	18
Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis	18
Characterization of LY3324954 a long-acting glucagon-receptor agonist	18
Obesity alters ovarian folliculogenesis through disrupted angiogenesis from increased IL-10 production	18
Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health	17
Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling	17
Tetracycline response element driven Cre causes ectopic recombinase activity independent of transactivator element	17
FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice	17
KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats	17
SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic β-cells	17
Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency	17
Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue	17
Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial–mesenchymal transition in diabetes	17
From type 1 diabetes biology to therapy: The Human Islet Research Network	17
Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle	17
Adipocyte-specific tribbles pseudokinase 1 regulates plasma adiponectin and plasma lipids in mice	17
Endothelial BBSome is essential for vascular, metabolic, and retinal functions	17
Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion	17
Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity	16
Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas	16
Dual specificity phosphatase 1 attenuates inflammation-induced cardiomyopathy by improving mitophagy and mitochondrial metabolism	16
Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics	16
Mutations in DNAJC19 cause altered mitochondrial structure and increased mitochondrial respiration in human iPSC-derived cardiomyocytes	16
Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA	16
The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis	16
Intestinal SEC16B modulates obesity by regulating chylomicron metabolism	16
Intrinsic cardiorespiratory fitness modulates clinical and molecular response to caloric restriction	16
Urocortin 2 promotes hypertrophy and enhances skeletal muscle function through cAMP and insulin/IGF-1 signaling pathways	16
Sensory spinal interoceptive pathways and energy balance regulation	16
Response-to Letter-to-the-editor: “A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice”	16
Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension	16
Multi-omics after O-GlcNAc alteration identified cellular processes promoting aneuploidy after loss of O-GlcNAc transferase	16
Physical exercise shapes the mouse brain epigenome	16
Obesity-induced miR-802 directly targets AMPK and promotes nonalcoholic steatohepatitis in mice	16
Lateral hypothalamus hypocretin/orexin glucose-inhibited neurons promote food seeking after calorie restriction	16
The mitochondrial tRNA-derived fragment, mt-tRF-LeuTAA, couples mitochondrial metabolism to insulin secretion	16
Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice	16
Ablation of IFNγ in myeloid cells suppresses liver inflammation and fibrogenesis in mice with hepatic small heterodimer partner (SHP) deletion	16
Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury	16