Molecular Metabolism

Article	Citations
10 years of Molecular Metabolism	308
Hepatic regulator of G protein signaling 14 ameliorates NAFLD through activating cAMP-AMPK signaling by targeting Giα1/3	224
Reprogramming hormone-sensitive prostate cancer to a lethal neuroendocrine cancer lineage by mitochondrial pyruvate carrier (MPC)	218
Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice	213
Deletion of the mitochondrial calcium uniporter in adipose tissue promotes energy expenditure and alleviates diet-induced obesity	179
GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity	172
Beta-hydroxybutyrate dampens adipose progenitors’ profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36-dependent mechanisms	161
Neuronal miR-29a protects from obesity in adult mice	156
Genome-wide meta-analysis of 92 cardiometabolic protein serum levels	125
Genetic and sex-specific regulation of mitochondrial function in gonadal and inguinal adipose tissue	105
Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions	98
ACAA1 knockout increases the survival rate of KPC mice by activating autophagy	98
TGF-β antagonism synergizes with PPARγ agonism to reduce fibrosis and enhance beige adipogenesis	96
Nutrient control of splice site selection contributes to methionine addiction of cancer	95
Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis	94
Physical training reduces cell senescence and associated insulin resistance in skeletal muscle	82
Endothelial TrkA coordinates vascularization and innervation in thermogenic adipose tissue and can be targeted to control metabolism	81
Dysregulated systemic metabolism in a Down syndrome mouse model	80
Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice	77
Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2	73
Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP	72
Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing	70
From type 1 diabetes biology to therapy: The Human Islet Research Network	68
Declining muscle NAD+ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation	67
Daily running enhances molecular and physiological circadian rhythms in skeletal muscle	67

Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling	66
TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis	64
Aregs-IGFBP3-mediated SMC-like cells apoptosis impairs beige adipocytes formation in aged mice	63
NFE2L1-mediated proteasome function protects from ferroptosis	63
The physiology of experimental overfeeding in animals	63
JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism	61
VGluT3 BNST neurons transmit GABA and restrict sucrose consumption	61
RNA binding proteins PCBP1 and PCBP2 regulate pancreatic β cell translation	61
Emerging molecular technologies for light-mediated modulation of pancreatic beta-cell function	61
KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats	60
Bioenergetic adaptations of small intestinal epithelial cells reduce cell differentiation enhancing intestinal permeability in obese mice	57
Endothelial BBSome is essential for vascular, metabolic, and retinal functions	57
The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR	56
Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages	54
Ketogenic diets composed of long-chain and medium-chain fatty acids induce cardiac fibrosis in mice	54
Hemostatic alterations linked to body fat distribution, fatty liver, and insulin resistance	53
GLP-1 physiology informs the pharmacotherapy of obesity	52
Survivin is essential for thermogenic program and metabolic homeostasis in mice	51
Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology	50
Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance	50
Corrigendum to “Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis” [Mol Metab 69 (2023) 1–13]	50
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome	49
VMHdm/cSF-1 neuronal circuits regulate skeletal muscle PGC1-α via the sympathoadrenal drive	48
Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe mice	48
Editorial Board, cover figure description and credits	47
Sestrin2 maintains hepatic immune homeostasis and redox balance partially via inhibiting RIPK3-mediated necroptosis in metabolic dysfunction-associated steatohepatitis	46
Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis	46
UCP2 mediates mitochondrial dynamics to induce AgRP neuronal activity	46
High-fat diet feeding disrupts the coupling of thermoregulation to energy homeostasis	46
LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK	44
miR-10a regulates cell death and inflammation in adipose tissue of male mice with diet-induced obesity	44
Dietary PUFAs drive diverse system-level changes in lipid metabolism	44
Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases	42
Apolipoprotein A-IV is induced by high-fat diets and mediates positive effects on glucose and lipid metabolism	42
Skeletal muscle BMAL1 is necessary for transcriptional adaptation of local and peripheral tissues in response to endurance exercise training	42
Impacts of essential amino acids on energy balance	41
MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives	40
Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation	40
EndoC-βH5 cells are storable and ready-to-use human pancreatic beta cells with physiological insulin secretion	40
Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice	40
Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome	40
Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice	39
A Cre-driver rat model for anatomical and functional analysis of glucagon (Gcg)-expressing cells in the brain and periphery	39
Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity	39
Editorial Board, cover figure description and credits	38
Genetic disruption of the Gipr in Apoe−/− mice promotes atherosclerosis	38
Loss of epidermal glucocorticoid receptor protects against whole body metabolic dysfunction upon chronic corticosterone treatment	38
Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism	38
Hypothalamic TTF-1 orchestrates the sensitivity of leptin	38
NPY derived from AGRP neurons controls feeding via Y1 and energy expenditure and food foraging behaviour via Y2 signalling	37

Editorial Board, cover figure description and credits	37
Picalm, a novel regulator of GLUT4-trafficking in adipose tissue	36
Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice	35
Linking metabolism and histone acetylation dynamics by integrated metabolic flux analysis of Acetyl-CoA and histone acetylation sites	35
Hepatic ketone body regulation of renal gluconeogenesis	35
Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging	33
Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis	33
Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function	33
Metabolic profiling of single cells by exploiting NADH and FAD fluorescence via flow cytometry	32
Adiponectin-receptor agonism prevents right ventricular tissue pathology in a mouse model of Duchenne muscular dystrophy	32
Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance	32
Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis	31
Alpha-melanocyte-stimulating hormone contributes to an anti-inflammatory response to lipopolysaccharide	31
Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2	31
Effects of curtailed sleep on cardiac stress biomarkers following high-intensity exercise	31
Reversing Pdgfrβ signaling restores metabolically active beige adipocytes by alleviating ILC2 suppression in aged and obese mice	31
Deficiency of the mitochondrial transporter SLC25A47 minimally impacts hepatic lipid metabolism in fasted and diet-induced obese mice	31
Chronic cAMP activation induces adipocyte browning through discordant biphasic remodeling of transcriptome and chromatin accessibility	30
PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα	30
Chronic hyperinsulinemia promotes human hepatocyte senescence	30
Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice	30
Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress	30
Dissecting a disynaptic central amygdala-parasubthalamic nucleus neural circuit that mediates cholecystokinin-induced eating suppression	30
Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism	30
Dietary Advanced Glycation End products interacting with the intestinal epithelium: What do we really know?	30
Decoding the immune dance: Unraveling the interplay between beta cells and type 1 diabetes	29
Cardiovascular protection by SGLT2 inhibitors – Do anti-inflammatory mechanisms play a role?	29
miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers	29
Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice	29
Glucagon-like peptide-2 pharmacotherapy activates hepatic Farnesoid X receptor-signaling to attenuate resection-associated bile acid loss in mice	29
Insulin: A pacesetter for the shape of modern biomedical science and the Nobel Prize	29
Targeting hepatic oxidative stress rescues bone loss in liver fibrosis	29
Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits	29
Systemic metabolic changes in acute and chronic lymphocytic choriomeningitis virus infection	29
Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle	28
Insulin regulates human pancreatic endocrine cell differentiation in vitro	28
New dawn for cancer cell death: Emerging role of lipid metabolism	28
Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob defi	28
Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin	27
The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice	27
A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice	27
RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells	27
Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mechanisms	27
Krüppel-like factor 5 remodels lipid metabolism in exercised skeletal muscle	26
A novel long non-coding RNA connects obesity to impaired adipocyte function	26
Corrigendum to “Kynurenic acid derived from mesentery regulates mesenteritis and colitis via inducing white adipose browning in Crohn's disease” [Mol Metab 99 (2025 Sep) 102203]	26
Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release	26
Weight Loss Reverses Obesity-Associated Impairments in Acute Gastrointestinal Stretch-Induced Suppression of Food Intake and Glucose Homeostasis	26
What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) review series	26
Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes	26
Oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei bidirectionally modulate food intake	26
ROCK1 regulates insulin secretion from β-cells	26
Crosstalk between TM4SF5 and GLUT8 regulates fructose metabolism in hepatic steatosis	26
TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner	26
Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib	25
An epigenome atlas of mouse adipocytes	25
Exercise training remodels inter-organ endocrine networks	25
ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance	25
Adropin expression reflects circadian, lipoprotein, and mitochondrial processes in human tissues	25
The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition	24
An efficient AAV vector system of Rec2 serotype for intravenous injection to study metabolism in brown adipocytes in vivo	24
Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation	24
A key role for parabrachial nucleus CGRP neurons in FGF1-Induced anorexia	24
Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body	24
Corrigendum to “Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis” [Mol Metab. 70 (2023) 101698]∗	24
The role of intestinal microbiota in physiologic and body compositional changes that accompany CLA-mediated weight loss in obese mice	23
Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice	23
Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL)	23
Structural principles of insulin formulation and analog design: A century of innovation	23
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction	23
Corrigendum to “Results from three phase 1 trials of NNC9204-1177, a glucagon/GLP-1 receptor co-agonist: effects on weight loss and safety in adults with overweight or obesity” [Mol Metab 78 (2023) 10	23
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity	23
Median eminence myelin continuously turns over in adult mice	23
Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes	23
Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis	23
Insulin resistance per se drives early and reversible dysbiosis-mediated gut barrier impairment and bactericidal dysfunction	22
Macrophages on the run: Exercise balances macrophage polarization for improved health	22
Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity	22
Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice	22
Editorial Board, cover figure description and credits	21

Nuclear functional role of metabolic enzymes and related metabolites: Focus on gene expression regulation	21
Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline	21
Gemigliptin, a DPP4 inhibitor, ameliorates nonalcoholic steatohepatitis through AMP-activated protein kinase-independent and ULK1-mediated autophagy	21
Editorial Board, cover figure description and credits	21
Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in pathological eating behavior	21
Glycolysis maintains AMPK activation in sorafenib-induced Warburg effect	21
Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation	21
Toward modeling metabolic state from single-cell transcriptomics	21
Intrinsic cardiorespiratory fitness modulates clinical and molecular response to caloric restriction	21
Dietary protein defends lean mass and maintains the metabolic benefits of glucagon receptor agonism in mice	20
Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury	20
Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice	20
The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis	20
Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo	20
Functional regulation of macrophages by Ces1d-mediated lipid signaling in immunometabolism	20
Gsα-dependent signaling is required for postnatal establishment of a functional β-cell mass	20
Microbiota and body weight control: Weight watchers within?	20
Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue	20
Deletion of PPARα in mouse brown adipocytes increases their De Novo Lipogenesis	19
SF1-specific deletion of the energy sensor AMPKγ2 induces obesity	19
Adipocyte Septin-7 attenuates obesogenic adipogenesis and promotes lipolysis to prevent obesity	19
Genetic depletion of adipose-derived Isthmin-1 causes hepatic steatosis	19
Corrigendum to single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-ex	19
Mutations in DNAJC19 cause altered mitochondrial structure and increased mitochondrial respiration in human iPSC-derived cardiomyocytes	19
Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response	19
The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis	19
Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage	18
Dorsolateral septum GLP-1R neurons regulate feeding via lateral hypothalamic projections	18
Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant	18
Mapping the transcriptional landscape of human white and brown adipogenesis using single-nuclei RNA-seq	18
Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice	18
Editorial Board, cover figure description and credits	18
A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production	18
The mitochondrial pyruvate carrier regulates adipose glucose partitioning in female mice	18
Sex hormone-binding globulin controls sex-specific lipolytic activity in human abdominal subcutaneous adipocytes	18
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network	18
Elevation of hypothalamic ketone bodies induces a decrease in energy expenditures and an increase risk of metabolic disorder	18
Roles and therapeutic targeting of ceramide metabolism in cancer	18
NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition	18
LRP1 in GABAergic neurons is a key link between obesity and memory function	18
Increased susceptibility to diet-induced obesity in female mice impairs ovarian steroidogenesis: The role of elevated leptin signalling on nodal activity inhibition in theca cells	18
Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway	18
Intestinal SEC16B modulates obesity by regulating chylomicron metabolism	18
Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-κB signaling pathway	18
Corrigendum to “Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice” [Mol Metab 82 (2024 April) 101906]	18
Hepatic retinol dehydrogenase 11 dampens stress associated with the maintenance of cellular cholesterol levels	18
Vertical sleeve gastrectomy increases duodenal Lactobacillus spp. richness associated with the activation of intestinal HIF2α signaling and metabolic benefits	17
Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids	17
Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis	17
Discovery of ecnoglutide – A novel, long-acting, cAMP-biased glucagon-like peptide-1 (GLP-1) analog	17
In celebration of a century with insulin – Update of insulin gene mutations in diabetes	17
Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice	17
Complete loss of PAX4 causes transient neonatal diabetes in humans	17
Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis	17
The gut-brain axis mediates bacterial driven modulation of reward signaling	17
Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alström syndrome	17
Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction	16
Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling	16
Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα	16
Autophagic signaling promotes systems-wide remodeling in skeletal muscle upon oncometabolic stress by D2-HG	16
Fatty Acid Synthase regulates glucose and energy homeostasis via POMC neurons and adrenergic signals	16
Exercise-induced hypothalamic neuroplasticity: Implications for energy and glucose metabolism	16
An early, reversible cholesterolgenic etiology of diet-induced insulin resistance	16
Effects of metformin on the gut microbiota: A systematic review	16
14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation	16
Regulation of body weight: Lessons learned from bariatric surgery	16
De novo labeling and trafficking of individual lipid species in live cells	16
Nipsnap1—A regulatory factor required for long-term maintenance of non-shivering thermogenesis	16
Editorial Board, cover figure description and credits	16
Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis	16
Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function	16
Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism	16
Uncovering the role of Gpr45 in obesity regulation	16
Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice	16