Molecular Metabolism

Article	Citations
Beta-hydroxybutyrate dampens adipose progenitors’ profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36-dependent mechanisms	344
10 years of Molecular Metabolism	256
Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice	173
Nutrient control of splice site selection contributes to methionine addiction of cancer	138
Genetic and sex-specific regulation of mitochondrial function in gonadal and inguinal adipose tissue	121
Hepatic regulator of G protein signaling 14 ameliorates NAFLD through activating cAMP-AMPK signaling by targeting Giα1/3	106
Reprogramming hormone-sensitive prostate cancer to a lethal neuroendocrine cancer lineage by mitochondrial pyruvate carrier (MPC)	106
TGF-β antagonism synergizes with PPARγ agonism to reduce fibrosis and enhance beige adipogenesis	104
Genome-wide meta-analysis of 92 cardiometabolic protein serum levels	99
ACAA1 knockout increases the survival rate of KPC mice by activating autophagy	89
Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2	85
Deletion of the mitochondrial calcium uniporter in adipose tissue promotes energy expenditure and alleviates diet-induced obesity	83
Neuronal miR-29a protects from obesity in adult mice	80
Dysregulated systemic metabolism in a Down syndrome mouse model	78
GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity	78
Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice	76
DYRK1A inhibition restores pancreatic functions and improves glucose metabolism in a preclinical model of type 2 diabetes	75
Endothelial TrkA coordinates vascularization and innervation in thermogenic adipose tissue and can be targeted to control metabolism	73
Impaired hepatic metabolism in Hereditary Fructose Intolerance confers fructose-independent risk for steatosis and hypertriglyceridemia	71
Physical training reduces cell senescence and associated insulin resistance in skeletal muscle	69
Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis	65
JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism	62
VGluT3 BNST neurons transmit GABA and restrict sucrose consumption	60
RNA binding proteins PCBP1 and PCBP2 regulate pancreatic β cell translation	58
Emerging molecular technologies for light-mediated modulation of pancreatic beta-cell function	57

TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis	57
Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing	56
Declining muscle NAD+ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation	55
Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP	54
NFE2L1-mediated proteasome function protects from ferroptosis	52
The liver clock modulates circadian rhythms in white adipose tissue	52
Daily running enhances molecular and physiological circadian rhythms in skeletal muscle	51
Ketogenic diets composed of long-chain and medium-chain fatty acids induce cardiac fibrosis in mice	51
Aregs-IGFBP3-mediated SMC-like cells apoptosis impairs beige adipocytes formation in aged mice	51
Bioenergetic adaptations of small intestinal epithelial cells reduce cell differentiation enhancing intestinal permeability in obese mice	49
Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages	49
The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR	49
GLP-1 physiology informs the pharmacotherapy of obesity	49
The physiology of experimental overfeeding in animals	48
Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis	47
Corrigendum to “Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis” [Mol Metab 69 (2023) 1–13]	47
High-fat diet feeding disrupts the coupling of thermoregulation to energy homeostasis	46
Survivin is essential for thermogenic program and metabolic homeostasis in mice	46
Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice	45
Dietary PUFAs drive diverse system-level changes in lipid metabolism	44
Apolipoprotein A-IV is induced by high-fat diets and mediates positive effects on glucose and lipid metabolism	43
A Cre-driver rat model for anatomical and functional analysis of glucagon (Gcg)-expressing cells in the brain and periphery	43
miR-10a regulates cell death and inflammation in adipose tissue of male mice with diet-induced obesity	42
Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism	42
Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity	42
UCP2 mediates mitochondrial dynamics to induce AgRP neuronal activity	42
Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome	41
Sestrin2 maintains hepatic immune homeostasis and redox balance partially via inhibiting RIPK3-mediated necroptosis in metabolic dysfunction-associated steatohepatitis	40
Impacts of essential amino acids on energy balance	40
EndoC-βH5 cells are storable and ready-to-use human pancreatic beta cells with physiological insulin secretion	39
VMHdm/cSF-1 neuronal circuits regulate skeletal muscle PGC1-α via the sympathoadrenal drive	39
Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases	38
Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation	38
Cold exposure induces the constitutively active thermogenic receptor, GPR3, via ERRα and ERRγ	38
LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK	37
MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives	36
Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance	36
Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology	36
Skeletal muscle BMAL1 is necessary for transcriptional adaptation of local and peripheral tissues in response to endurance exercise training	35
Genetic disruption of the Gipr in Apoe−/− mice promotes atherosclerosis	35
Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice	35
Metabolic profiling of single cells by exploiting NADH and FAD fluorescence via flow cytometry	34
Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice	34
Editorial Board, cover figure description and credits	34
Alpha-melanocyte-stimulating hormone contributes to an anti-inflammatory response to lipopolysaccharide	34
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome	34
Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging	33
Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice	33
Linking metabolism and histone acetylation dynamics by integrated metabolic flux analysis of Acetyl-CoA and histone acetylation sites	33
Loss of epidermal glucocorticoid receptor protects against whole body metabolic dysfunction upon chronic corticosterone treatment	32

Editorial Board, cover figure description and credits	32
Hypothalamic TTF-1 orchestrates the sensitivity of leptin	32
Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance	31
Adiponectin-receptor agonism prevents right ventricular tissue pathology in a mouse model of Duchenne muscular dystrophy	31
Picalm, a novel regulator of GLUT4-trafficking in adipose tissue	31
Hepatic ketone body regulation of renal gluconeogenesis	31
NPY derived from AGRP neurons controls feeding via Y1 and energy expenditure and food foraging behaviour via Y2 signalling	31
Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function	31
Regulation of food intake by Connexin43 via adipocyte-sensory neuron electrical synapses	30
Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits	30
Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis	30
Effects of curtailed sleep on cardiac stress biomarkers following high-intensity exercise	30
Chronic cAMP activation induces adipocyte browning through discordant biphasic remodeling of transcriptome and chromatin accessibility	29
Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress	29
Glucagon-like peptide-2 pharmacotherapy activates hepatic Farnesoid X receptor-signaling to attenuate resection-associated bile acid loss in mice	28
Increased TGF-β/Activin-Smad2 signaling is associated with pancreatic β-cell dysfunction and glucose intolerance in gestational diabetes mellitus	28
Systemic metabolic changes in acute and chronic lymphocytic choriomeningitis virus infection	28
Chronic hyperinsulinemia promotes human hepatocyte senescence	28
Cardiovascular protection by SGLT2 inhibitors – Do anti-inflammatory mechanisms play a role?	28
Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice	27
Nutritional regulation of metabolism-dependent and-independent glucosensing in the mammalian taste system	27
Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism	27
Reversing Pdgfrβ signaling restores metabolically active beige adipocytes by alleviating ILC2 suppression in aged and obese mice	26
Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2	26
Dietary Advanced Glycation End products interacting with the intestinal epithelium: What do we really know?	25
Deficiency of the mitochondrial transporter SLC25A47 minimally impacts hepatic lipid metabolism in fasted and diet-induced obese mice	25
Dissecting a disynaptic central amygdala-parasubthalamic nucleus neural circuit that mediates cholecystokinin-induced eating suppression	25
Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle	24
Decoding the immune dance: Unraveling the interplay between beta cells and type 1 diabetes	24
Corrigendum to “Kynurenic acid derived from mesentery regulates mesenteritis and colitis via inducing white adipose browning in Crohn's disease” [Mol Metab 99 (2025 Sep) 102203]	24
Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice	24
Crosstalk between TM4SF5 and GLUT8 regulates fructose metabolism in hepatic steatosis	24
Weight loss reverses obesity-associated impairments in acute gastrointestinal stretch-induced suppression of food intake and glucose homeostasis	23
TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner	23
RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells	23
ROCK1 regulates insulin secretion from β-cells	23
Insulin regulates human pancreatic endocrine cell differentiation in vitro	23
A novel long non-coding RNA connects obesity to impaired adipocyte function	22
Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes	22
NLRP3 inhibition by VTX3232 tempers inflammation resulting in reduced body weight, hyperglycemia, and hepatic steatosis in obese male mice	22
The transcription factor CUX1 exerts opposing roles in human and mouse adipocyte differentiation	22
Transient juvenile hypoglycemia in GH insensitive Laron syndrome pigs is associated with insulin hypersensitivity	22
Protein kinase D deficiency induces a senescence-like phenotype in β-cells and improves glucose and insulin tolerance under high-fat diet conditions	22
Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob defi	22
Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mechanisms	22
The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice	22
New dawn for cancer cell death: Emerging role of lipid metabolism	22
Targeting hepatic oxidative stress rescues bone loss in liver fibrosis	21
Insulin resistance per se drives early and reversible dysbiosis-mediated gut barrier impairment and bactericidal dysfunction	21
Krüppel-like factor 5 remodels lipid metabolism in exercised skeletal muscle	21
Oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei bidirectionally modulate food intake	21
Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in pathological eating behavior	21
A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice	21
Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation	21
A key role for parabrachial nucleus CGRP neurons in FGF1-Induced anorexia	21
Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice	20
Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL)	20
Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib	20
Nuclear functional role of metabolic enzymes and related metabolites: Focus on gene expression regulation	20
ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance	20
Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis	20
Corrigendum to “Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis” [Mol Metab. 70 (2023) 101698]∗	20
An epigenome atlas of mouse adipocytes	20
Adropin expression reflects circadian, lipoprotein, and mitochondrial processes in human tissues	20
Are we giving too much weight to lean mass loss?	20
Corrigendum to “Results from three phase 1 trials of NNC9204-1177, a glucagon/GLP-1 receptor co-agonist: effects on weight loss and safety in adults with overweight or obesity” [Mol Metab 78 (2023) 10	20
Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release	20
The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition	19
Exercise training remodels inter-organ endocrine networks	19
An efficient AAV vector system of Rec2 serotype for intravenous injection to study metabolism in brown adipocytes in vivo	19
The role of intestinal microbiota in physiologic and body compositional changes that accompany CLA-mediated weight loss in obese mice	19
Median eminence myelin continuously turns over in adult mice	19
Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation	18
Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes	18
Adipocyte Septin-7 attenuates obesogenic adipogenesis and promotes lipolysis to prevent obesity	18
Toward modeling metabolic state from single-cell transcriptomics	18
Glycolysis maintains AMPK activation in sorafenib-induced Warburg effect	18
Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body	18
Macrophages on the run: Exercise balances macrophage polarization for improved health	18
Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation	18

Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity	18
Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo	18
Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline	18
Loss of GLP-2R signaling in Glp2r/- mice increases the long-term severity of graft versus host disease	18
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction	18
Mutations in DNAJC19 cause altered mitochondrial structure and increased mitochondrial respiration in human iPSC-derived cardiomyocytes	18
Genetic depletion of adipose-derived Isthmin-1 causes hepatic steatosis	18
Elevation of hypothalamic ketone bodies induces a decrease in energy expenditures and an increase risk of metabolic disorder	17
The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis	17
Editorial Board, cover figure description and credits	17
Editorial Board, cover figure description and credits	17
Intrinsic cardiorespiratory fitness modulates clinical and molecular response to caloric restriction	17
Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice	16
Editorial Board, cover figure description and credits	16
Autophagic signaling promotes systems-wide remodeling in skeletal muscle upon oncometabolic stress by D2-HG	16
Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant	16
Functional regulation of macrophages by Ces1d-mediated lipid signaling in immunometabolism	16
Intestinal SEC16B modulates obesity by regulating chylomicron metabolism	16
Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice	16
Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue	16
Microbiota and body weight control: Weight watchers within?	16
Corrigendum to “Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice” [Mol Metab 82 (2024 April) 101906]	16
Dietary protein defends lean mass and maintains the metabolic benefits of glucagon receptor agonism in mice	16
SF1-specific deletion of the energy sensor AMPKγ2 induces obesity	16
Corrigendum to single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-ex	16
Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia	16
Gemigliptin, a DPP4 inhibitor, ameliorates nonalcoholic steatohepatitis through AMP-activated protein kinase-independent and ULK1-mediated autophagy	16
Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-κB signaling pathway	16
Mapping the transcriptional landscape of human white and brown adipogenesis using single-nuclei RNA-seq	16
Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response	16
Vertical sleeve gastrectomy increases duodenal Lactobacillus spp. richness associated with the activation of intestinal HIF2α signaling and metabolic benefits	16
Deletion of PPARα in mouse brown adipocytes increases their De Novo Lipogenesis	16
Beta cell secreted GABA sets appropriate insulin secretion by modulating islet calcium oscillations	16
Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury	16
Reprogramming of cholesterol sensing in epithelial cells supports pancreatic inflammation	16
Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alström syndrome	15
Sex hormone-binding globulin controls sex-specific lipolytic activity in human abdominal subcutaneous adipocytes	15
Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism	15
Nipsnap1—A regulatory factor required for long-term maintenance of non-shivering thermogenesis	15
Additive effects of GLY-200 (oral pharmacologic duodenal exclusion therapy) and GLP-1R agonist in obesity management	15
Uncovering the role of Gpr45 in obesity regulation	15
Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice	15
Complete loss of PAX4 causes transient neonatal diabetes in humans	15
The mitochondrial pyruvate carrier regulates adipose glucose partitioning in female mice	15
Regulation of HDL dysfunctionality by phosphatidylethanolamine links poly-unsaturated fatty acids with atherosclerotic cardiovascular diseases	15
Fatty Acid Synthase regulates glucose and energy homeostasis via POMC neurons and adrenergic signals	15
A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production	15
Dorsolateral septum GLP-1R neurons regulate feeding via lateral hypothalamic projections	15
Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle	15
Hepatic retinol dehydrogenase 11 dampens stress associated with the maintenance of cellular cholesterol levels	15
Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids	14
Regulation of body weight: Lessons learned from bariatric surgery	14
Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway	14
The gut-brain axis mediates bacterial driven modulation of reward signaling	14
Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis	14
The neglected PCK1/glucagon (inter)action in nutrient homeostasis beyond gluconeogenesis: Disease pathogenesis and treatment	14
Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice	14
Increased susceptibility to diet-induced obesity in female mice impairs ovarian steroidogenesis: The role of elevated leptin signalling on nodal activity inhibition in theca cells	14
De novo labeling and trafficking of individual lipid species in live cells	14
NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition	14
Discovery of ecnoglutide – A novel, long-acting, cAMP-biased glucagon-like peptide-1 (GLP-1) analog	14
Roles and therapeutic targeting of ceramide metabolism in cancer	14
Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis	14
Exercise-induced hypothalamic neuroplasticity: Implications for energy and glucose metabolism	14
Effects of metformin on the gut microbiota: A systematic review	14
LRP1 in GABAergic neurons is a key link between obesity and memory function	14
Deletion of miPEP in adipocytes protects against obesity and insulin resistance by boosting muscle metabolism	14