Molecular Metabolism

Article	Citations
GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art	522
Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies	211
Diabetes, infection risk and COVID-19	203
Dysregulated lipid metabolism links NAFLD to cardiovascular disease	197
Metabolic-associated fatty liver disease and lipoprotein metabolism	193
Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease	148
Compartmentalised acyl-CoA metabolism and roles in chromatin regulation	143
A guide to understanding endoplasmic reticulum stress in metabolic disorders	137
Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans	135
Mechanisms of insulin resistance related to white, beige, and brown adipocytes	128
Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street	121
GLP-1 physiology informs the pharmacotherapy of obesity	120
The melanocortin pathway and energy homeostasis: From discovery to obesity therapy	114
Role of NAD+ in regulating cellular and metabolic signaling pathways	108
Insulin action at a molecular level – 100 years of progress	103
A non-proliferative role of pyrimidine metabolism in cancer	100
Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD	100
Hepatokines and metabolism: Deciphering communication from the liver	97
Insulin-like growth factors: Ligands, binding proteins, and receptors	95
Metabolic drivers of non-alcoholic fatty liver disease	93
Imaging biomarkers of NAFLD, NASH, and fibrosis	85
The brain as an insulin-sensitive metabolic organ	84
Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis	73
Genetic and epigenetic factors determining NAFLD risk	72
Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis	66

Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D	64
Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms	62
Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy	60
CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing	60
Understanding insulin and its receptor from their three-dimensional structures	59
GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer's disease	58
Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability	58
Ferroptosis and ferritinophagy in diabetes complications	56
Two genomes, one cell: Mitochondrial-nuclear coordination via epigenetic pathways	55
Sodium-glucose co-transporter2 expression and inflammatory activity in diabetic atherosclerotic plaques: Effects of sodium-glucose co-transporter2 inhibitor treatment	54
Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation	54
Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells	52
Irisin: Still chasing shadows	52
Mitochondrial oxidative function in NAFLD: Friend or foe?	52
Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome	51
Exploring the therapeutic potential of mitochondrial uncouplers in cancer	50
Partial leptin deficiency confers resistance to diet-induced obesity in mice	48
Interactions between metabolism and chromatin in plant models	48
PPARγ and PPARα synergize to induce robust browning of white fat in vivo	47
Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload	46
Suppressing adipocyte inflammation promotes insulin resistance in mice	45
Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice	45
Cross-omics analysis revealed gut microbiome-related metabolic pathways underlying atherosclerosis development after antibiotics treatment	45
Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes	44
Therapeutic potential of mitochondrial uncouplers for the treatment of metabolic associated fatty liver disease and NASH	43
Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways	42
AhR activation defends gut barrier integrity against damage occurring in obesity	42
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction	42
A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing	41
Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction	40
Role and mechanism of ferroptosis in neurological diseases	39
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists	39
Chromatin-remodeling links metabolic signaling to gene expression	39
FGF19 and FGF21: In NASH we trust	39
Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet	38
LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue	38
Non-alcoholic fatty liver disease and steatohepatitis: State of the art on effective therapeutics based on the gold standard method for diagnosis	37
Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion	37
The taming of PARP1 and its impact on NAD+ metabolism	36
Chromatin dynamics and histone modifications in intestinal microbiota-host crosstalk	36
Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease	36
Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior	35
Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes	35
Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes	35
Impacts of essential amino acids on energy balance	35
Testosterone metabolites differentially regulate obesogenesis and fat distribution	35
Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue	35
Interplay between RNA-binding protein HuR and Nox4 as a novel therapeutic target in diabetic kidney disease	34
Adipocyte-specific Beclin1 deletion impairs lipolysis and mitochondrial integrity in adipose tissue	34
LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases	34

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists	34
Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo	33
De novo discovery of metabolic heterogeneity with immunophenotype-guided imaging mass spectrometry	33
Regulation of hepatic glutamine metabolism by miR-122	33
Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise	33
Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat	33
Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease	33
LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway	32
Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function	32
Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH	31
MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives	31
An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesis	31
Insulin's actions on vascular tissues: Physiological effects and pathophysiological contributions to vascular complications of diabetes	31
Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis	31
Organelle transporters and inter-organelle communication as drivers of metabolic regulation and cellular homeostasis	31
The gut–brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders	30
Dietary ω3-and ω6-Polyunsaturated fatty acids reconstitute fertility of Juvenile and adult Fads2-Deficient mice	30
Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta cells	30
Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with β-cell failure	30
Skeletal muscle in healthy humans exhibits a day-night rhythm in lipid metabolism	29
Review: Glucose-sensitive insulin	29
RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression	29
Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application	29
Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis	29
Prior exercise in humans redistributes intramuscular GLUT4 and enhances insulin-stimulated sarcolemmal and endosomal GLUT4 translocation	28
High-fat diet induces time-dependent synaptic plasticity of the lateral hypothalamus	28
Chronic inflammation and the hallmarks of aging	28
Mitochondrial function in intestinal epithelium homeostasis and modulation in diet-induced obesity	28
Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms	28
Reappraisal of the optimal fasting time for insulin tolerance tests in mice	28
Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes	28
The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis	28
Ovarian cancer modulates the immunosuppressive function of CD11b+Gr1+ myeloid cells via glutamine metabolism	27
NF-κB signaling in tanycytes mediates inflammation-induced anorexia	27
P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response	27
CD81 marks immature and dedifferentiated pancreatic β-cells	27
Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance	27
Growth differentiation factor 15 as a potential therapeutic for treating obesity	27
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity	27
Glucose-induced insulin secretion in isolated human islets: Does it truly reflect β-cell function in vivo?	27
Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes	27
Gut microbiota impairs insulin clearance in obese mice	27
Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease	26
Microbiota and body weight control: Weight watchers within?	26
Update on the effects of energy metabolism in bone marrow mesenchymal stem cells differentiation	26
PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments	26
Metabolic insights from a GHSR-A203E mutant mouse model	26
“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”	26
ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα2	26
ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model	26
Toward modeling metabolic state from single-cell transcriptomics	26
Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport	25
β-catenin regulates muscle glucose transport via actin remodelling and M-cadherin binding	25
SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans	25
Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation	25
Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice	25
BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy	25
Novel noncoding RNA CircPTK2 regulates lipolysis and adipogenesis in cachexia	25
Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus	25
Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent	25
Cardiovascular protection by SGLT2 inhibitors – Do anti-inflammatory mechanisms play a role?	24
Stress kinases in the development of liver steatosis and hepatocellular carcinoma	24
Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN	24
Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states	24
Whole-brain activation signatures of weight-lowering drugs	24
Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis	24
Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice	23
Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice	23
Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling	23
Prolonged fasting drives a program of metabolic inflammation in human adipose tissue	23
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis	22
Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism	22
The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis	22
Regulation of inflammation in diabetes: From genetics to epigenomics evidence	22
Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling	22
New dawn for cancer cell death: Emerging role of lipid metabolism	22
Metformin-induced reductions in tumor growth involves modulation of the gut microbiome	22
Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation	22
Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation	22
Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling	22

Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions	22
Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue	22
Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals	22
Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression	22
Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons	22
Farnesoid X receptor contributes to body weight-independent improvements in glycemic control after Roux-en-Y gastric bypass surgery in diet-induced obese mice	22
Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia—the effects of blocking myostatin and activins	21
In celebration of a century with insulin – Update of insulin gene mutations in diabetes	21
Parathyroid hormone (PTH) regulation of metabolic homeostasis: An old dog teaches us new tricks	21
Peroxisomal regulation of energy homeostasis: Effect on obesity and related metabolic disorders	21
Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-κB signaling pathway	21
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression	21
p21 induces a senescence program and skeletal muscle dysfunction	21
17β-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERα signaling	21
Functional changes of the liver in the absence of growth hormone (GH) action – Proteomic and metabolomic insights from a GH receptor deficient pig model	20
URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice	20
Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity	20
Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice	20
Neuroanatomical organization and functional roles of PVN MC4R pathways in physiological and behavioral regulations	20
PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP-1 receptor agonist-induced tachycardia in mice	20
Tryptophan metabolism is a physiological integrator regulating circadian rhythms	20
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network	20
LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway	20
Serum integrative omics reveals the landscape of human diabetic kidney disease	20
Roles of bone-derived hormones in type 2 diabetes and cardiovascular pathophysiology	20
Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk	20
The role of exercise-induced peripheral factors in sleep regulation	20
What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) review series	19
Cigarette smoke exposure impairs β-cell function through activation of oxidative stress and ceramide accumulation	19
Insulin and obesity transform hypothalamic-pituitary-adrenal axis stemness and function in a hyperactive state	19
Role of ATP-binding cassette transporter A1 in suppressing lipid accumulation by glucagon-like peptide-1 agonist in hepatocytes	19
A Neural basis for Octanoic acid regulation of energy balance	19
GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans	19
Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels	19
FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations	19
Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation	19
Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo	19
A novel lncRNA RP11-386G11.10 reprograms lipid metabolism to promote hepatocellular carcinoma progression	19
Early life lessons: The lasting effects of germline epigenetic information on organismal development	19
Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice	18
Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity	18
Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis	18
Sensory neurons expressing calcitonin gene-related peptide α regulate adaptive thermogenesis and diet-induced obesity	18
Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction	18
Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases	18
Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction	18
Short-term inhibition of autophagy benefits pancreatic β-cells by augmenting ether lipids and peroxisomal function, and by countering depletion of n-3 polyunsaturated fatty acids after fat-feeding	18
Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems	17
Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle	17
Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity	17
Wild-type IDH2 contributes to Epstein–Barr virus-dependent metabolic alterations and tumorigenesis	17
Targeting cellular senescence in metabolic disease	17
Osteocalcin and vascular function: is there a cross-talk?	17
MBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma	17
Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice	17
Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism	17
Type 2 diabetes subgroups and potential medication strategies in relation to effects on insulin resistance and beta-cell function: A step toward personalised diabetes treatment?	17
Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin	17
Notum deacylates octanoylated ghrelin	17
Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice	17
Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice	17
Translating glucose tolerance data from mice to humans: Insights from stable isotope labelled glucose tolerance tests	17
The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR	17
Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis	17
Intestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis	17
Moderate SIRT1 overexpression protects against brown adipose tissue inflammation	17
Plasma triacylglycerols are biomarkers of β-cell function in mice and humans	17
Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice	17