OOIR: Observatory of International Research

Papers

(The H4-Index of Redox Biology is 93. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Apolipoprotein E is required for brain iron homeostasis in mice	447
The protective role of GPX4 in naïve ESCs is highlighted by induced ferroptosis resistance through GPX4 expression	376
GAPDH inhibition mediated by thiol oxidation in human airway epithelial cells exposed to an environmental peroxide	303
Corrigendum to “N-butylphthalide (NBP) and ligustrazine (TMP) triazole hybrids target the KEAP1-NRF2 pathway to inhibit ferroptosis and exert brain neuroprotectivity” [Redox Biol. 86, (2025), 103835]	289
DMNQ induces ferroptosis and augments the efficacy of anti-PD-L1 immunotherapy in gastric cancer via the STAT3/SLC1A4 axis to mediate cysteine metabolism reprogramming	280
Triclosan exacerbates post-myocardial infarction injury via Nur77 ubiquitination: Linking NTRK2/PGC-1α-mediated mitochondrial dysfunction to senescence and ferroptosis	276
Corrigendum to “A viral–host redox axis: EBNA1–FOSL2–ALDH3A1 defines a targetable vulnerability in EBV-positive carcinomas” [Redox Biol. 90 (2026) 104025]	252
A promising drug repurposing approach for Alzheimer's treatment: Givinostat improves cognitive behavior and pathological features in APP/PS1 mice	250
Endothelial MerTK impairment accelerates the development of atherosclerosis	247
SLC22A3 deficiency leads to cognitive impairment through the cardio-neuroinflammatory axis mediated HA/H1R/NLRP3 pathway in heart failure mice	242
Mitochondrial translational control in cardiovascular diseases: from mechanisms to therapies	242
Coronin 1a-mediated F-actin disassembly controls effector function in murine neutrophils	236
Multi-omics profiling reveals Chitinase-3-like protein 1 as a key mediator in the crosstalk between sarcopenia and liver cancer	216
Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice	212
Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases	211
Autophagy activation is required for N6-methyladenosine modification to regulate ferroptosis in hepatocellular carcinoma	211
The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adults	210
Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification	199
Mechano-activated connexin hemichannels and glutathione transport protect lens fiber cells against oxidative insults	199
NADPH oxidase 1: A target in the capacity of dimeric ECG and EGCG procyanidins to inhibit colorectal cancer cell invasion	194
An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology	191
CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway	183
Melatonin attenuates atherosclerotic plaque vulnerability through SIRT6-dependent regulation of vascular smooth muscle cells senescence	177
Fatty acid nitroalkenes – Multi-target agents for the treatment of sickle cell disease	162
Organic Selenium induces ferroptosis in pancreatic cancer cells	156

PM2.5-induced iron homeostasis imbalance triggers cardiac hypertrophy through ferroptosis in a selective autophagy crosstalk manner	156
Thioredoxin-interacting protein as a crucial regulator in asthma exacerbation induced by copper oxide nanoparticles in a mouse model	155
Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress	155
OXPHOS inhibition overcomes chemoresistance in triple negative breast cancer	152
Oxidative stress response and NRF2 signaling pathway in autism spectrum disorder	151
SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc	151
Inhibition of spinal ferroptosis-like cell death alleviates hyperalgesia and spontaneous pain in a mouse model of bone cancer pain	149
Fullerol rescues the light-induced retinal damage by modulating Müller glia cell fate	149
SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential	149
Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing	145
Serinc2-STAT3 protects against doxorubicin-induced cardiotoxicity via promoting mitochondrial bioenergetics	144
A quantitative proteomic approach to evaluate the efficacy of carnosine in a murine model of chronic obstructive pulmonary disease (COPD)	142
Synergistic induction of ferroptosis by targeting HERC1-NCOA4 axis to enhance the photodynamic sensitivity of osteosarcoma	140
Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle	139
Human ultrarare genetic disorders of sulfur metabolism demonstrate redundancies in H2S homeostasis	137
The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis	137
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53–P21/Nrf2 activation in a HuR-dependent m6A manner	135
Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases	134
Glutathione peroxidase 3 is essential for countering senescence in adipose remodelling by maintaining mitochondrial homeostasis	134
ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis	133
Type 2 Diabetes mellitus alters the cargo of (poly)phenol metabolome and the oxidative status in circulating lipoproteins	133
TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis	133
Integrated regulation of stress responses, autophagy and survival by altered intracellular iron stores	130
Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress	130
Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO	129
The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species	128
Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies	128
Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia	126
Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation	126
Small extracellular vesicles orchestrated pathological communications between breast cancer cells and cardiomyocytes as a novel mechanism exacerbating anthracycline cardiotoxicity by fueling ferroptos	123
Age-related declines in mitochondrial Prdx6 contribute to dysregulated muscle bioenergetics	122
Development of nitroalkene-based inhibitors to target STING-dependent inflammation	121
Role of DDX1 in the oxidative response of ataxia telangiectasia patient-derived fibroblasts	121
Hyperglycemia triggers RyR2-dependent alterations of mitochondrial calcium homeostasis in response to cardiac ischemia-reperfusion: Key role of DRP1 activation	118
A model of mitochondrial superoxide production during ischaemia-reperfusion injury for therapeutic development and mechanistic understanding	117
New insights into extracellular and intracellular redox status in COVID-19 patients	117
Selenium deficiency impedes maturation of parvalbumin interneurons, perineuronal nets, and neural network activity	116
ALDH1L2 induces resistance to chemotherapy in small cell lung cancer by inhibiting ferroptosis	115
Inhibition of mitochondrial complex I leading to NAD+/NADH imbalance in type 2 diabetic patients who developed late stent thrombosis: Evidence from an integrative analysis of platelet bioenergetics an	115
Nutrigenomics and redox regulation: Concepts relating to the Special Issue on nutrigenomics	114
HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3	114
ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis	114
Beyond M1/M2: The role of reactive oxygen species in liver fibrosis and immune modulation	111
Female sex is a risk factor for exacerbated lipid peroxidation and disease in murine retinitis pigmentosa	109
Myeloid ACE2 protects against septic hypotension and vascular dysfunction through Ang-(1–7)-Mas-mediated macrophage polarization	109
Sweroside alleviates pressure overload-induced heart failure through targeting CaMKⅡδ to inhibit ROS-mediated NF-κB/NLRP3 in cardiomyocytes	109
Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction	108
Estrogen receptor β deficiency increases the susceptibility to ulcerative colitis by inducing mitochondrial fission and consequently accelerating senescence of colonic epithelial cells	108
The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury	107
Tubastatin A potently inhibits GPX4 activity to potentiate cancer radiotherapy through boosting ferroptosis	107

Redox shuttle of cytosolic Thioredoxin to mitochondria protects against hyperoxia-mediated alteration of mitochondrial structure and dysfunction	105
Release of hepatic xanthine oxidase (XO) to the circulation is protective in intravascular hemolytic crisis	105
S-nitrosylation of paired-related homeobox 1 promotes cardiac remodeling following myocardial infarction	105
Corrigendum to “Natural mutations of human XDH promote the nitrite (NO2−)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?” [Redox Biol. 4 (67) (2023) 102864]	104
Dietary sulfur amino acid restriction in humans with overweight and obesity: Evidence of an altered plasma and urine sulfurome, and a novel metabolic signature that correlates with loss of fat mass an	103
Retraction notice to “Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell” [Redox Biol. 11 (2017) 322–334]	103
Disulfide stress and its role in cardiovascular diseases	101
Peroxiredoxin Ⅲ mitigates mitochondrial H2O2-mediated damage and supports quality control in cardiomyocytes under hypoxia-reoxygenation stress	101
Cytoglobin scavenges intracellular hydrogen peroxide and regulates redox signals in the vasculature	99
Recovery of reduced thiol groups by superoxide-mediated denitrosation of nitrosothiols	99
CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson's disease	97
FOXF1 and SHH participate in the regulation of iron signaling in pulmonary fibrosis	96
Transfer of H2O2 from Mitochondria to the endoplasmic reticulum via Aquaporin-11	96
FTMT-mediated suppression of mitophagy links iron accumulation to osteoporosis	96
Mitochondrial cholesterol: Metabolism and impact on redox biology and disease	95
Supplement-driven iron overload accelerates phenotypic aging via inflammatory biomarkers: Potential counteraction through anti-inflammatory or antioxidant diets	95
PM2.5 increases susceptibility to acute exacerbation of COPD via NOX4/Nrf2 redox imbalance-mediated mitophagy	93
Poor glycaemic control in type 2 diabetes compromises leukocyte oxygen consumption rate, OXPHOS complex content and neutrophil-endothelial interactions	93
Acute stimulation of glucose metabolism by H2O2 sustains the NADPH steady-state under oxidative stress	93
DRD4 alleviates acute kidney injury by suppressing ISG15/NOX4 axis-associated oxidative stress	93