OOIR: Observatory of International Research

Papers

(The H4-Index of Redox Biology is 83. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice	394
The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species	345
Type 2 Diabetes mellitus alters the cargo of (poly)phenol metabolome and the oxidative status in circulating lipoproteins	317
Corrigendum to “N-butylphthalide (NBP) and ligustrazine (TMP) triazole hybrids target the KEAP1-NRF2 pathway to inhibit ferroptosis and exert brain neuroprotectivity” [Redox Biol. 86, (2025), 103835]	257
The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis	236
An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology	229
GAPDH inhibition mediated by thiol oxidation in human airway epithelial cells exposed to an environmental peroxide	209
Oxidative stress response and NRF2 signaling pathway in autism spectrum disorder	207
Fatty acid nitroalkenes – Multi-target agents for the treatment of sickle cell disease	201
Endothelial MerTK impairment accelerates the development of atherosclerosis	190
Thioredoxin-interacting protein as a crucial regulator in asthma exacerbation induced by copper oxide nanoparticles in a mouse model	189
Coronin 1a-mediated F-actin disassembly controls effector function in murine neutrophils	189
Mechano-activated connexin hemichannels and glutathione transport protect lens fiber cells against oxidative insults	188
Human ultrarare genetic disorders of sulfur metabolism demonstrate redundancies in H2S homeostasis	185
A promising drug repurposing approach for Alzheimer's treatment: Givinostat improves cognitive behavior and pathological features in APP/PS1 mice	183
A quantitative proteomic approach to evaluate the efficacy of carnosine in a murine model of chronic obstructive pulmonary disease (COPD)	181
OXPHOS inhibition overcomes chemoresistance in triple negative breast cancer	171
The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adults	170
Apolipoprotein E is required for brain iron homeostasis in mice	167
Fullerol rescues the light-induced retinal damage by modulating Müller glia cell fate	167
Melatonin attenuates atherosclerotic plaque vulnerability through SIRT6-dependent regulation of vascular smooth muscle cells senescence	165
CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway	161
Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control	159
Autophagy activation is required for N6-methyladenosine modification to regulate ferroptosis in hepatocellular carcinoma	146
PM2.5-induced iron homeostasis imbalance triggers cardiac hypertrophy through ferroptosis in a selective autophagy crosstalk manner	144

Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases	139
Small extracellular vesicles orchestrated pathological communications between breast cancer cells and cardiomyocytes as a novel mechanism exacerbating anthracycline cardiotoxicity by fueling ferroptos	139
Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO	137
Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia	132
Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress	132
The protective role of GPX4 in naïve ESCs is highlighted by induced ferroptosis resistance through GPX4 expression	130
NADPH oxidase 1: A target in the capacity of dimeric ECG and EGCG procyanidins to inhibit colorectal cancer cell invasion	126
Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle	123
Inhibition of spinal ferroptosis-like cell death alleviates hyperalgesia and spontaneous pain in a mouse model of bone cancer pain	121
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53–P21/Nrf2 activation in a HuR-dependent m6A manner	117
SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential	116
Integrated regulation of stress responses, autophagy and survival by altered intracellular iron stores	115
SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc	113
Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation	112
TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis	111
ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis	111
Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress	111
Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies	110
Multi-omics profiling reveals Chitinase-3-like protein 1 as a key mediator in the crosstalk between sarcopenia and liver cancer	110
Synergistic induction of ferroptosis by targeting HERC1-NCOA4 axis to enhance the photodynamic sensitivity of osteosarcoma	110
Glutathione peroxidase 3 is essential for countering senescence in adipose remodelling by maintaining mitochondrial homeostasis	110
Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases	109
Organic Selenium induces ferroptosis in pancreatic cancer cells	109
Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing	106
DRD4 alleviates acute kidney injury by suppressing ISG15/NOX4 axis-associated oxidative stress	105
Release of hepatic xanthine oxidase (XO) to the circulation is protective in intravascular hemolytic crisis	104
Myeloid ACE2 protects against septic hypotension and vascular dysfunction through Ang-(1–7)-Mas-mediated macrophage polarization	103
Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death	102
Acute stimulation of glucose metabolism by H2O2 sustains the NADPH steady-state under oxidative stress	101
Cytoglobin scavenges intracellular hydrogen peroxide and regulates redox signals in the vasculature	101
Role of DDX1 in the oxidative response of ataxia telangiectasia patient-derived fibroblasts	101
New insights into extracellular and intracellular redox status in COVID-19 patients	100
Dietary sulfur amino acid restriction in humans with overweight and obesity: Evidence of an altered plasma and urine sulfurome, and a novel metabolic signature that correlates with loss of fat mass an	99
Female sex is a risk factor for exacerbated lipid peroxidation and disease in murine retinitis pigmentosa	99
A model of mitochondrial superoxide production during ischaemia-reperfusion injury for therapeutic development and mechanistic understanding	98
Recovery of reduced thiol groups by superoxide-mediated denitrosation of nitrosothiols	96
HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3	96
Corrigendum to “Natural mutations of human XDH promote the nitrite (NO2−)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?” [Redox Biol. 4 (67) (2023) 102864]	96
Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction	96
REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2	96
Retraction notice to “Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell” [Redox Biol. 11 (2017) 322–334]	95
Redox shuttle of cytosolic Thioredoxin to mitochondria protects against hyperoxia-mediated alteration of mitochondrial structure and dysfunction	93
Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus	93
Peroxiredoxin Ⅲ mitigates mitochondrial H2O2-mediated damage and supports quality control in cardiomyocytes under hypoxia-reoxygenation stress	92
Age-related declines in mitochondrial Prdx6 contribute to dysregulated muscle bioenergetics	90
Accumulation of acetaldehyde in aldh2.1 zebrafish causes increased retinal angiogenesis and impaired glucose metabolism	89
Selenium deficiency impedes maturation of parvalbumin interneurons, perineuronal nets, and neural network activity	87
FOXF1 and SHH participate in the regulation of iron signaling in pulmonary fibrosis	87
Transfer of H2O2 from Mitochondria to the endoplasmic reticulum via Aquaporin-11	86
Fatty acid nitroalkene reversal of established lung fibrosis	86

Beyond M1/M2: The role of reactive oxygen species in liver fibrosis and immune modulation	85
Disulfide stress and its role in cardiovascular diseases	85
Estrogen receptor β deficiency increases the susceptibility to ulcerative colitis by inducing mitochondrial fission and consequently accelerating senescence of colonic epithelial cells	85
HDAC6 inhibitor-loaded brain-targeted nanocarrier-mediated neuroprotection in methamphetamine-driven Parkinson's disease	85
Development of nitroalkene-based inhibitors to target STING-dependent inflammation	84
S-nitrosylation of paired-related homeobox 1 promotes cardiac remodeling following myocardial infarction	84
Nutrigenomics and redox regulation: Concepts relating to the Special Issue on nutrigenomics	83
The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury	83