Stem Cell Reports

Papers
(The median citation count of Stem Cell Reports is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)
ArticleCitations
A versatile in vivo platform for reversible control of transgene expression in adult tissues204
Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes118
Pen-2 regulates glial homeostasis by coordinating self-renewal and transdifferentiation programs in oligodendrocyte precursor cells106
Ribosomal proteins regulate 2-cell-stage transcriptome in mouse embryonic stem cells87
Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies79
Effect of Notch1 signaling on muscle engraftment and maturation from pluripotent stem cells77
Reconstruction of dynamic regulatory networks reveals signaling-induced topology changes associated with germ layer specification68
Dissecting the impact of differentiation stage, replicative history, and cell type composition on epigenetic clocks65
MSCohi-O lenses for long-term retention of mesenchymal stem cells on ocular surface as a therapeutic approach for chronic ocular graft-versus-host disease58
Stem cells in your YouTube feed: The complex landscape and unexpected mediators of online information57
YAP signaling in horizontal basal cells promotes the regeneration of olfactory epithelium after injury56
Familial Alzheimer’s disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling56
Hsp70-Bim interaction mediated mitophagy as a potential therapeutic target for CML stem cells53
USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development51
Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers48
Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning44
Plasticity of ocular surface epithelia: Using a murine model of limbal stem cell deficiency to delineate metaplasia and transdifferentiation43
Connie Eaves (1944–2024)43
GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation43
Functionally redundant roles of ID family proteins in spermatogonial stem cells42
In and out: Benchmarking in vitro, in vivo, ex vivo, and xenografting approaches for an integrative brain disease modeling pipeline42
Human spinal GABA neurons survive and mature in the injured nonhuman primate spinal cord42
Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment41
Discovery of NANOG enhancers and their essential roles in self-renewal and differentiation in human embryonic stem cells41
Differentiation success of reprogrammed cells is heterogeneous in vivo and modulated by somatic cell identity memory41
Bone morphogenetic protein 4 induces hematopoietic stem cell development from murine hemogenic endothelial cells in culture40
Complex haploinsufficiency in pluripotent cells yields somatic cells with DNA methylation abnormalities and pluripotency induction defects39
Stabilization of cell-cell adhesions prevents symmetry breaking and locks in pluripotency in 3D gastruloids38
Single-cell approaches define two groups of mammalian oligodendrocyte precursor cells and their evolution over developmental time38
H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency38
Pluripotent stem cell lines available for use in clinical applications: A comprehensive overview38
DOT1L regulates lung developmental epithelial cell fate and adult alveolar stem cell differentiation after acute injury37
Medium acidosis drives cardiac differentiation during mesendoderm cell fate specification from human pluripotent stem cells36
A novel paradigm for single-cell annotation in stem cell research36
Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation36
Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research36
Ependymal and neural stem cells are close relatives35
Response to: SARS-CoV-2 and type I interferon signaling in brain endothelial cells: Blurring the lines between friend or foe35
Extracellular-vesicle-mediated transfer of let-7b/7c promotes the proliferation of transition-state spermatogonia in neonatal mouse testis35
Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis34
Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome34
UHRF1 interacts with snRNAs and regulates alternative splicing in mouse spermatogonial stem cells34
Glutamine boosts intestinal stem cell-mediated small intestinal epithelial development during early weaning: Involvement of WNT signaling33
Searching for information about stem cells online in an age of artificial intelligence: How should the stem cell community respond?33
Lessons learnt, and still to learn, in first in human stem cell trials33
Human fetal tissue is critical for biomedical research33
Gene reactivation upon erosion of X chromosome inactivation in female hiPSCs is predictable yet variable and persists through differentiation32
Public perceptions and expectations: Disentangling the hope and hype of organoid research32
Generation of highly pure pluripotent stem cell-derived myogenic progenitor cells and myotubes32
DOT1L inhibition enhances pluripotency beyond acquisition of epithelial identity and without immediate suppression of the somatic transcriptome32
Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells32
Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids31
Inhibition of BMP signaling with LDN 193189 can influence bone marrow stromal cell fate but does not prevent hypertrophy during chondrogenesis31
The role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages31
BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming30
Mechanical force-promoted osteoclastic differentiation via periodontal ligament stem cell exosomal protein ANXA330
Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy30
Aged human serum induces vascular changes in an isogenic co-culture venule model29
Neutrophils as regulators of macrophage-induced inflammation in a setting of allogeneic bone marrow transplantation29
What does “appropriate scientific justification” mean for the review of human pluripotent stem cell, embryo, and related research?29
MEF2C/p300-mediated epigenetic remodeling promotes the maturation of induced cardiomyocytes29
Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming28
Non-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variants28
Regeneration of spermatogenesis by mouse germ cell transplantation into allogeneic and xenogeneic testis primordia or organoids28
CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells28
Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation27
Leveraging CRISPR activation for rapid assessment of gene editing products in human pluripotent stem cells27
DeePhys: A machine learning–assisted platform for electrophysiological phenotyping of human neuronal networks26
Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment26
Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells26
Inhibition of N-myristoyltransferase in pluripotent stem cells promotes the naive state in mice and elicits trophectoderm and primitive endoderm markers in humans26
Low fucosylation defines the glycocalyx of progenitor cells and melanocytes in the human limbal stem cell niche26
Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology26
Metabolic remodeling in hiPSC-derived myofibers carrying the m.3243A>G mutation26
A single cell-based computational platform to identify chemical compounds targeting desired sets of transcription factors for cellular conversion26
Transplantation of human pluripotent stem cell-derived retinal sheet in a primate model of macular hole26
Interspecies chimerism with human embryonic stem cells generates functional human dopamine neurons at low efficiency25
The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling25
Prosaposin maintains adult neural stem cells in a state associated with deep quiescence25
Characterizing hypoxia-orchestrated post-stroke changes in oligodendrocyte precursor cells for optimized cell therapy25
Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems25
Generation of canine induced pluripotent stem cells under feeder-free conditions using Sendai virus vector encoding six canine reprogramming factors25
Mowat-Wilson syndrome factor ZEB2 controls early formation of human neural crest through BMP signaling modulation25
Critical considerations for public engagement in stem cell-related research25
Involvement of LIN28A in Wnt-dependent regulation of hippocampal neurogenesis in the aging brain24
Aggregation of cryopreserved mid-hindgut endoderm for more reliable and reproducible hPSC-derived small intestinal organoid generation24
Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes24
Patient-specific and gene-corrected induced pluripotent stem cell-derived endothelial cells elucidate single-cell phenotype of pulmonary veno-occlusive disease23
Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models23
Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes23
Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model22
Titin-truncating variants in hiPSC cardiomyocytes induce pathogenic proteinopathy and sarcomere defects with preserved core contractile machinery22
Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction22
Modeling in vivo induction of gastric insulin-secreting cells using transplanted human stomach organoids22
Derivation of functional trophoblast stem cells from primed human pluripotent stem cells22
Elimination of tumorigenic pluripotent stem cells from their differentiated cell therapy products: An important step toward ensuring safe cell therapy22
Modeling sex differences in humans using isogenic induced pluripotent stem cells22
AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype22
Deep-supercooling preservation of stem cell spheroids for chondral defect repairment21
Embryonic stem cell ERK, AKT, plus STAT3 response dynamics combinatorics are heterogeneous but NANOG state independent21
The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development21
Toti: An integrated multi-omics database to decipher the epigenetic regulation of gene expression in totipotent stem cells21
Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration21
A year of engagement and growth: ISSCR’s year-end message from the president 2022–202321
Small-molecule inhibitor cocktail promotes the proliferation of pre-existing liver progenitor cells21
Identification of glioblastoma stem cell-associated lncRNAs using single-cell RNA sequencing datasets21
Fibroblast fate determination during cardiac reprogramming by remodeling of actin filaments21
The novel tRF-23 promotes osteogenic differentiation of hBMSCs and protects against bone loss in ovariectomized mice21
MIXL1 activation in endoderm differentiation of human induced pluripotent stem cells21
Aberrant nucleosome organization in mouse SCNT embryos revealed by ULI-MNase-seq21
Ribosome biogenesis controls cranial suture MSC fate via the complement pathway in mouse and human iPSC models20
Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro20
Scalable generation of sensory neurons from human pluripotent stem cells20
Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants20
Dual inhibition of MAPK and PI3K/AKT pathways enhances maturation of human iPSC-derived cardiomyocytes20
Businesses marketing purported stem cell treatments and exosome therapies for COVID-19: An analysis of direct-to-consumer online advertising claims20
Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells20
RBFOX2-dependent alternative splicing of Numb regulates Notch signaling during muscle stem cell activation20
Reconstituted ovaries self-assemble without an ovarian surface epithelium20
DDX41 is needed for pre- and postnatal hematopoietic stem cell differentiation in mice20
Generation, genomic characterization, and differentiation of triploid human embryonic stem cells19
Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors19
Ins and outs of HSCs and VEGF-induced vascular remodeling: Toward improved HSC mobilization and engraftment19
Zika virus induces FOXG1 nuclear displacement and downregulation in human neural progenitors19
The KAP1 chromatin regulator and Paupar long non-coding RNA control subventricular zone neural stem cell maintenance and neurogenesis19
The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation19
Cell-autonomous and non-cell-autonomous roles of NKCC1 in regulating neural stem cell quiescence in the hippocampal dentate gyrus19
Modeling glioma intratumoral heterogeneity with primary human neural stem and progenitor cells19
A conserved function of EZH2-PRC2 in repression of primitive endoderm fate in mouse and human pluripotent cells19
MAC-1 marks a quiescent and functionally superior HSC subset during regeneration19
Inducing human retinal pigment epithelium-like cells from somatic tissue19
Engineering human neuronal diversity: Morphogens and stem cell technologies for neurodevelopmental biology19
Argonaute proteins regulate a specific network of genes through KLF4 in mouse embryonic stem cells19
Satellite glial contact enhances differentiation and maturation of human iPSC-derived sensory neurons18
Prolonged generation of multi-lineage blood cells in wild-type animals from pluripotent stem cells18
Differentiation of brain and retinal organoids from confluent cultures of pluripotent stem cells connected by nerve-like axonal projections of optic origin18
Long noncoding RNA Lnc530 localizes on R-loops and regulates R-loop formation and genomic stability in mouse embryonic stem cells18
Graft-derived horizontal cells contribute to host-graft synapses in degenerated retinas after retinal organoid transplantation18
ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development18
Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration18
Astrocytes originated from neural stem cells drive the regenerative remodeling of pathologic CSPGs in spinal cord injury18
Human CRX regulates photoreceptor cells development via bidirectional transcriptional control in retinal organoids18
Adult hippocampal neurogenesis: New avenues for treatment of brain disorders17
Chitinase-like protein 3: A novel niche factor for mouse neural stem cells17
APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids17
Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting17
Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection17
An efficient, non-viral arrayed CRISPR screening platform for iPSC-derived myeloid and microglia models17
Subventricular zone adult mouse neural stem cells require insulin receptor for self-renewal17
Human microglial cells as a therapeutic target in a neurodevelopmental disease model17
A Chemically Defined Feeder-free System for the Establishment and Maintenance of the Human Naive Pluripotent State17
Spatial transcriptomics reveals molecular cues underlying the site specificity of the adult mouse oral mucosa and its stem cell niches17
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes17
ERRγ agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation16
GSK3α negatively regulates GSK3β by decreasing its protein levels and enzymatic activity in mouse embryonic stem cells16
Neuroblast migration along cellular substrates in the developing porcine brain16
Seamless and non-destructive monitoring of extracellular microRNAs during cardiac differentiation from human pluripotent stem cells16
A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells16
Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes16
Pluripotent cell states and unexpected fates16
Oligodendrocytes in human induced pluripotent stem cell-derived cortical grafts remyelinate adult rat and human cortical neurons16
Retinoic acid signaling guides the efficiency of inner ear organoid-genesis and governs sensory-nonsensory fate specification16
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants16
Accelerated mitochondrial dynamics promote spermatogonial differentiation15
Rigor and reproducibility in human brain organoid research: Where we are and where we need to go15
Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration15
DOT1L interaction partner AF10 controls patterning of H3K79 methylation and RNA polymerase II to maintain cell identity15
METTL3 uncouples chromatin accessibility from transcription during retinal development15
Patient-derived parathyroid organoids as a tracer and drug-screening application model15
Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cells15
Transcription factor co-expression mediates lineage priming for embryonic and extra-embryonic differentiation15
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells15
Human iPSC-derived photoreceptor transplantation in the cone dominant 13-lined ground squirrel15
Interleukin-1β induces trained innate immunity in human hematopoietic progenitor cells in vitro15
CD37 regulates the self-renewal of leukemic stem cells via integrin-mediated signaling in acute myeloid leukemia15
Unraveling the impact of ZZZ3 on the mTOR/ribosome pathway in human embryonic stem cells homeostasis15
Activation of canonical Wnt signaling is required for efficient direct reprogramming into human hepatic progenitor cells15
Human macula formation involves two waves of retinoic acid suppression via CYP26A1 that modulate cell cycle exit and cone subtype specification14
Cell position within human pluripotent stem cell colonies determines apical specialization via an actin cytoskeleton-based mechanism14
mTORC2-mediated cell-cell interactions promote BMP4-induced WNT activation and mesoderm differentiation14
Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film14
Safe CNV removal is crucial for successful hESC-RPE transplantation in wet age-related macular degeneration14
Cell size regulates human endoderm specification through actomyosin-dependent AMOT-YAP signaling14
Telmisartan is neuroprotective in a hiPSC-derived spinal microtissue model for C9orf72 ALS via inhibition of neuroinflammation14
SnapShot: Reporting practices for publishing results with human PSCs and tissue stem cells14
Proteomics-based receptor-ligand matching enhances differentiation maturity of human-stem-cell-derived neurons14
Advances in intravital imaging of adult neurogenesis in mice14
Generation of a TPH2-EGFP reporter cell line for purification and monitoring of human serotonin neurons in vitro and in vivo14
PI3Kβ-regulated β-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression14
Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells14
Clonal lineage tracing and transcriptomics of cortical progenitor populations reveal maintenance of differentiation potential13
The urgent need for clear and concise regulations on exosome-based interventions13
Auxilin regulates intestinal stem cell proliferation through EGFR13
A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants13
Aging disrupts gene expression timing during muscle regeneration13
An expedition in the jungle of pluripotent stem cells of non-human primates13
Leveraging interacting signaling pathways to robustly improve the quality and yield of human pluripotent stem cell-derived hepatoblasts and hepatocytes13
High-content phenotyping of Parkinson's disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification13
AT7867 promotes pancreatic progenitor differentiation of human iPSCs13
A critical role of retinoic acid concentration for the induction of a fully human-like atrial action potential phenotype in hiPSC-CM13
Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses13
Human iPSC-derived salivary gland cell sheets integrate with injured glands to form glandular structures13
Identification of unapproved orthopedic regenerative medicine: Usefulness of the Act on Safety of Regenerative Medicine13
Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets13
Swift induction of human spinal lower motor neurons and robust ALS cell screening via single-cell imaging13
SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss13
Development of a platform to investigate long-term potentiation in human iPSC-derived neuronal networks13
The rise of neural stem cells: From development to disease13
Survivors of polymicrobial sepsis are refractory to G-CSF-induced emergency myelopoiesis and hematopoietic stem and progenitor cell mobilization13
Dynamic governance: A new era for consent for stem cell research12
Restoration of fertility in nonablated recipient mice after spermatogonial stem cell transplantation12
Dual CRISPR-Cas3 system for inducing multi-exon skipping in DMD patient-derived iPSCs12
Prepubertal androgen signaling is required to establish male fat distribution12
The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research12
Disruption of normal stem cell function and transmission of myelodysplastic syndrome by self-renewal of committed myeloid lineage cells12
Molecular pathology of Usher 1B patient-derived retinal organoids at single cell resolution12
O-GlcNAcase regulates pluripotency states of human embryonic stem cells12
Single-cell transcriptome and surfaceome profiling of the adult human retinal pigment epithelium12
History and current status of clinical studies using human pluripotent stem cells12
The role of UBE3A in the autism and epilepsy-related Dup15q syndrome using patient-derived, CRISPR-corrected neurons12
Message from the editor-in-chief12
Heparan sulfate regulates the fate decisions of human pluripotent stem cells12
Tubastatin A maintains adult skeletal muscle stem cells in a quiescent state ex vivo and improves their engraftment ability in vivo12
Engineering human pluripotent stem cell lines to evade xenogeneic transplantation barriers12
Exercise promotes the functional integration of human stem cell-derived neural grafts in a rodent model of Parkinson’s disease12
Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia11
Modeling diabetic alpha cell dysfunction using stem cell-derived alpha cells11
Transitioning from human primordial germ cells to embryonic germ cells11
ERK phosphorylates ESRRB to regulate the self-renewal and differentiation of mouse embryonic stem cells11
Lineage-specific dynamics of loss of X upregulation during inactive-X reactivation11
Optimized prime editing of the Alzheimer’s disease-associated APOE4 mutation11
Validation of non-destructive morphology-based selection of cerebral cortical organoids by paired morphological and single-cell RNA-seq analyses11
BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer’s patients’ iPSCs in senescence-related conditions11
Generation of SIV-resistant T cells and macrophages from nonhuman primate induced pluripotent stem cells with edited CCR5 locus11
Advances and challenges in modeling Charcot-Marie-Tooth type 2A using iPSC-derived models11
Integrin β1 activity controls colony morphology during human pluripotent stem cell state transitions11
Dissecting Oct4 enhancer function in pluripotent stem cells and mouse embryogenesis11
Dynamic spatiotemporal activation of a pervasive neurogenic competence in striatal astrocytes supports continuous neurogenesis following injury11
Human pluripotent stem cell-derived macrophages host Mycobacterium abscessus infection11
Polycomb repressive complex 2 regulates basal cell fate during adult olfactory neurogenesis11
Mutations in FUS lead to synaptic dysregulation in ALS-iPSC derived neurons11
Single-cell analysis of human fetal epicardium reveals its cellular composition and identifies CRIP1 as a modulator of EMT11
Understanding and modeling regional specification of the human ganglionic eminence11
Autophagy is essential for human myelopoiesis10
Retinal transplant immunology and advancements10
The impact of consanguinity on the design of iPSC banks10
Salt-inducible kinases transduce mechanical forces into the specification of the pancreatic endocrine lineage10
PKM2 is a key factor to regulate neurogenesis and cognition by controlling lactate homeostasis10
XPRESSO: Rapid genetic engineering of human pluripotent stem cells for durable overexpression using a modular anti-silencing vector10
A short history of pluripotent stem cells markers10
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