Stem Cell Reports

Article	Citations
MSCohi-O lenses for long-term retention of mesenchymal stem cells on ocular surface as a therapeutic approach for chronic ocular graft-versus-host disease	113
Stem cells in your YouTube feed: The complex landscape and unexpected mediators of online information	110
USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development	108
Familial Alzheimer’s disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling	93
Dissecting the impact of differentiation stage, replicative history, and cell type composition on epigenetic clocks	67
Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies	63
Ribosomal proteins regulate 2-cell-stage transcriptome in mouse embryonic stem cells	59
Pen-2 regulates glial homeostasis by coordinating self-renewal and transdifferentiation programs in oligodendrocyte precursor cells	55
Effect of Notch1 signaling on muscle engraftment and maturation from pluripotent stem cells	54
Diversity of cortical progenitors directs neuronal layer formation and regional glial patterning	54
Hsp70-Bim interaction mediated mitophagy as a potential therapeutic target for CML stem cells	51
Therapeutic reactivation of hippocampal progenitors reverse cognition decline in mice with progressive brain demyelination	50
A versatile in vivo platform for reversible control of transgene expression in adult tissues	50
Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment	47
Discovery of kidney disease targets using multimodal human podocyte injury models	46
Connie Eaves (1944–2024)	45
Anesthetic-induced neurodevelopmental changes with region-specific responses to propofol in forebrain organoids	45
Bone morphogenetic protein 4 induces hematopoietic stem cell development from murine hemogenic endothelial cells in culture	45
In and out: Benchmarking in vitro, in vivo, ex vivo, and xenografting approaches for an integrative brain disease modeling pipeline	44
Stabilization of cell-cell adhesions prevents symmetry breaking and locks in pluripotency in 3D gastruloids	43
A novel paradigm for single-cell annotation in stem cell research	41
Differentiation success of reprogrammed cells is heterogeneous in vivo and modulated by somatic cell identity memory	41
Plasticity of ocular surface epithelia: Using a murine model of limbal stem cell deficiency to delineate metaplasia and transdifferentiation	40
Discovery of NANOG enhancers and their essential roles in self-renewal and differentiation in human embryonic stem cells	40
Complex haploinsufficiency in pluripotent cells yields somatic cells with DNA methylation abnormalities and pluripotency induction defects	40

Human spinal GABA neurons survive and mature in the injured nonhuman primate spinal cord	39
Pluripotent stem cell lines available for use in clinical applications: A comprehensive overview	39
H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency	39
Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research	39
DOT1L regulates lung developmental epithelial cell fate and adult alveolar stem cell differentiation after acute injury	39
Single-cell approaches define two groups of mammalian oligodendrocyte precursor cells and their evolution over developmental time	37
Human iPSC-derived neural progenitor cells rescue motor function and brain pathology in symptomatic Canavan disease mice	37
Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation	36
Closing the gap? China’s new regulation on biomedical technologies	36
Microbiota from young mice restore the function of aged ISCs	36
Suppression of ATM kinase signaling accelerates cellular senescence	34
Selective Cav1.3 inhibition promotes survival of transplanted dopaminergic neurons via the CaMKII-p65-p53 pathway	34
Functionally redundant roles of ID family proteins in spermatogonial stem cells	34
CD157+ vascular endothelial stem cells represent a conserved subpopulation with an angiogenic gene expression profile	34
Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells	33
Medium acidosis drives cardiac differentiation during mesendoderm cell fate specification from human pluripotent stem cells	33
Searching for information about stem cells online in an age of artificial intelligence: How should the stem cell community respond?	33
Messenger RNA delivery into Sertoli cells restores fertility to congenitally infertile male mice	33
Ependymal and neural stem cells are close relatives	33
What does “appropriate scientific justification” mean for the review of human pluripotent stem cell, embryo, and related research?	32
Glutamine boosts intestinal stem cell-mediated small intestinal epithelial development during early weaning: Involvement of WNT signaling	31
Neutrophils as regulators of macrophage-induced inflammation in a setting of allogeneic bone marrow transplantation	31
Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b	31
Aged human serum induces vascular changes in an isogenic co-culture venule model	30
Generation of highly pure pluripotent stem cell-derived myogenic progenitor cells and myotubes	30
A humanized engineered heart tissue platform for cardiotoxicity assessment	30
Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome	30
MEF2C/p300-mediated epigenetic remodeling promotes the maturation of induced cardiomyocytes	29
Extracellular-vesicle-mediated transfer of let-7b/7c promotes the proliferation of transition-state spermatogonia in neonatal mouse testis	29
Human fetal tissue is critical for biomedical research	29
The role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages	29
UHRF1 interacts with snRNAs and regulates alternative splicing in mouse spermatogonial stem cells	29
Gene reactivation upon erosion of X chromosome inactivation in female hiPSCs is predictable yet variable and persists through differentiation	28
Lessons learnt, and still to learn, in first in human stem cell trials	28
BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming	28
Public perceptions and expectations: Disentangling the hope and hype of organoid research	28
Low fucosylation defines the glycocalyx of progenitor cells and melanocytes in the human limbal stem cell niche	27
Mechanical force-promoted osteoclastic differentiation via periodontal ligament stem cell exosomal protein ANXA3	27
Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis	27
Atypical cell cycle regulation over neural stem cell expansion	27
DeePhys: A machine learning–assisted platform for electrophysiological phenotyping of human neuronal networks	26
A single cell-based computational platform to identify chemical compounds targeting desired sets of transcription factors for cellular conversion	26
Non-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variants	26
Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment	26
Inhibition of N-myristoyltransferase in pluripotent stem cells promotes the naive state in mice and elicits trophectoderm and primitive endoderm markers in humans	26
What we thought we knew about TNF—And what we now must re-learn	26
CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells	26
Leveraging CRISPR activation for rapid assessment of gene editing products in human pluripotent stem cells	26
Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology	25
Metabolic remodeling in hiPSC-derived myofibers carrying the m.3243A>G mutation	25

Multiome-based identification of molecular markers for prospective identification of platelet-biased HSCs	25
Cloud-connected pluripotent stem cell platform enhances scientific identity in underrepresented students	24
Transplantation of human pluripotent stem cell-derived retinal sheet in a primate model of macular hole	23
Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model	23
New legal category of ‘advanced regenerative medicine treatment’ in Korea’s amended regenerative medicine law: comparative lessons from Japan	23
Modeling in vivo induction of gastric insulin-secreting cells using transplanted human stomach organoids	23
Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells	23
Critical considerations for public engagement in stem cell-related research	23
Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes	23
Interspecies chimerism with human embryonic stem cells generates functional human dopamine neurons at low efficiency	23
Patient-specific and gene-corrected induced pluripotent stem cell-derived endothelial cells elucidate single-cell phenotype of pulmonary veno-occlusive disease	23
Modeling sex differences in humans using isogenic induced pluripotent stem cells	23
Mowat-Wilson syndrome factor ZEB2 controls early formation of human neural crest through BMP signaling modulation	23
Prosaposin maintains adult neural stem cells in a state associated with deep quiescence	22
Generation of canine induced pluripotent stem cells under feeder-free conditions using Sendai virus vector encoding six canine reprogramming factors	22
Toward standardized iPSC testing: Insights from a multi-year international Quality Assessment Round	22
Titin-truncating variants in hiPSC cardiomyocytes induce pathogenic proteinopathy and sarcomere defects with preserved core contractile machinery	22
Involvement of LIN28A in Wnt-dependent regulation of hippocampal neurogenesis in the aging brain	22
Aggregation of cryopreserved mid-hindgut endoderm for more reliable and reproducible hPSC-derived small intestinal organoid generation	22
AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype	21
Histone methyltransferase Setd8 preserves chromatin accessibility to safeguard retinal progenitor cell identity during development	21
Characterizing hypoxia-orchestrated post-stroke changes in oligodendrocyte precursor cells for optimized cell therapy	21
The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling	21
Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems	21
Elimination of tumorigenic pluripotent stem cells from their differentiated cell therapy products: An important step toward ensuring safe cell therapy	21
Small-molecule inhibitor cocktail promotes the proliferation of pre-existing liver progenitor cells	20
Reconstituted ovaries self-assemble without an ovarian surface epithelium	20
A year of engagement and growth: ISSCR’s year-end message from the president 2022–2023	20
Fibroblast fate determination during cardiac reprogramming by remodeling of actin filaments	20
Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants	20
Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration	20
The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development	20
Toti: An integrated multi-omics database to decipher the epigenetic regulation of gene expression in totipotent stem cells	20
Exit from naive pluripotency proceeds with variable latency but without asymmetric division to generate population heterogeneity	20
Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models	20
Businesses marketing purported stem cell treatments and exosome therapies for COVID-19: An analysis of direct-to-consumer online advertising claims	19
Aberrant nucleosome organization in mouse SCNT embryos revealed by ULI-MNase-seq	19
Identification of glioblastoma stem cell-associated lncRNAs using single-cell RNA sequencing datasets	19
Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction	19
RBFOX2-dependent alternative splicing of Numb regulates Notch signaling during muscle stem cell activation	19
The novel tRF-23 promotes osteogenic differentiation of hBMSCs and protects against bone loss in ovariectomized mice	19
Deep-supercooling preservation of stem cell spheroids for chondral defect repairment	19
Scalable generation of sensory neurons from human pluripotent stem cells	19
Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells	19
Embryonic stem cell ERK, AKT, plus STAT3 response dynamics combinatorics are heterogeneous but NANOG state independent	19
MIXL1 activation in endoderm differentiation of human induced pluripotent stem cells	19
Ribosome biogenesis controls cranial suture MSC fate via the complement pathway in mouse and human iPSC models	19
The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation	18
Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting	18
Cell-autonomous and non-cell-autonomous roles of NKCC1 in regulating neural stem cell quiescence in the hippocampal dentate gyrus	18
Human CRX regulates photoreceptor cells development via bidirectional transcriptional control in retinal organoids	18
Derivation and analysis of human somatic sensory neuron subtypes facilitated through fluorescent hPSC reporters	18
Dual inhibition of MAPK and PI3K/AKT pathways enhances maturation of human iPSC-derived cardiomyocytes	18
Ins and outs of HSCs and VEGF-induced vascular remodeling: Toward improved HSC mobilization and engraftment	18
A conserved function of EZH2-PRC2 in repression of primitive endoderm fate in mouse and human pluripotent cells	18
Prolonged generation of multi-lineage blood cells in wild-type animals from pluripotent stem cells	17
Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration	17
Satellite glial contact enhances differentiation and maturation of human iPSC-derived sensory neurons	17
Engineering human neuronal diversity: Morphogens and stem cell technologies for neurodevelopmental biology	17
Generation, genomic characterization, and differentiation of triploid human embryonic stem cells	17
Zika virus induces FOXG1 nuclear displacement and downregulation in human neural progenitors	17
Long noncoding RNA Lnc530 localizes on R-loops and regulates R-loop formation and genomic stability in mouse embryonic stem cells	17
MAC-1 marks a quiescent and functionally superior HSC subset during regeneration	17
Diversity-in-a-dish: A practical framework for hiPSC model development	17
Astrocytes originated from neural stem cells drive the regenerative remodeling of pathologic CSPGs in spinal cord injury	17
The KAP1 chromatin regulator and Paupar long non-coding RNA control subventricular zone neural stem cell maintenance and neurogenesis	17
Human microglial cells as a therapeutic target in a neurodevelopmental disease model	17
Mitochondrial toxins cause widespread downregulation of pathways in X-linked dystonia-parkinsonism patient-derived neurons	16
Graft-derived horizontal cells contribute to host-graft synapses in degenerated retinas after retinal organoid transplantation	16
Modeling glioma intratumoral heterogeneity with primary human neural stem and progenitor cells	16
Chitinase-like protein 3: A novel niche factor for mouse neural stem cells	16
Retinoic acid signaling guides the efficiency of inner ear organoid-genesis and governs sensory-nonsensory fate specification	16
ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development	16
Adult hippocampal neurogenesis: New avenues for treatment of brain disorders	16
Human organoids: Fit for drug discovery?	16
Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cells	16
Patient-derived parathyroid organoids as a tracer and drug-screening application model	16
Generating high-quality porcine iPSCs with the new medium cocktail LACID	16
Spatially resolved transcriptomics identifies intercellular signaling post-ischemic stroke that controls neural stem cell proliferation	16
Electron transport chain complex I and mitochondrial fusion regulate ROS for differentiation in Drosophila neural stem cells	16

An efficient, non-viral arrayed CRISPR screening platform for iPSC-derived myeloid and microglia models	16
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes	16
APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids	15
A Chemically Defined Feeder-free System for the Establishment and Maintenance of the Human Naive Pluripotent State	15
Development of a high-efficiency induction system for embryonic oral epithelium from human pluripotent stem cells	15
Neuroblast migration along cellular substrates in the developing porcine brain	15
Spatial transcriptomics reveals molecular cues underlying the site specificity of the adult mouse oral mucosa and its stem cell niches	15
Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection	15
GSK3α negatively regulates GSK3β by decreasing its protein levels and enzymatic activity in mouse embryonic stem cells	15
A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells	15
Accelerated mitochondrial dynamics promote spermatogonial differentiation	15
Interleukin-1β induces trained innate immunity in human hematopoietic progenitor cells in vitro	15
Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes	15
ERRγ agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation	15
Oligodendrocytes in human induced pluripotent stem cell-derived cortical grafts remyelinate adult rat and human cortical neurons	15
SnapShot: Reporting practices for publishing results with human PSCs and tissue stem cells	14
Atg5 deficiency alters myofibroblast accumulation and alveolar regeneration in lung fibrosis	14
Generation of a TPH2-EGFP reporter cell line for purification and monitoring of human serotonin neurons in vitro and in vivo	14
A critical role of retinoic acid concentration for the induction of a fully human-like atrial action potential phenotype in hiPSC-CM	14
Seamless and non-destructive monitoring of extracellular microRNAs during cardiac differentiation from human pluripotent stem cells	14
Molecular signature of human endometrial stem/progenitor cells at the single-cell level	14
METTL3 uncouples chromatin accessibility from transcription during retinal development	14
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells	14
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants	14
Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells	14
Human iPSC-derived photoreceptor transplantation in the cone dominant 13-lined ground squirrel	14
mTORC2-mediated cell-cell interactions promote BMP4-induced WNT activation and mesoderm differentiation	13
SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss	13
Telmisartan is neuroprotective in a hiPSC-derived spinal microtissue model for C9orf72 ALS via inhibition of neuroinflammation	13
Cellular immunotherapy for COVID-19-induced acute respiratory distress syndrome: Results of the CIRCA-19 phase 1 safety and phase 2 randomized controlled trials	13
Advances in intravital imaging of adult neurogenesis in mice	13
Cell size regulates human endoderm specification through actomyosin-dependent AMOT-YAP signaling	13
Transcription factor co-expression mediates lineage priming for embryonic and extra-embryonic differentiation	13
Human macula formation involves two waves of retinoic acid suppression via CYP26A1 that modulate cell cycle exit and cone subtype specification	13
Unraveling the impact of ZZZ3 on the mTOR/ribosome pathway in human embryonic stem cells homeostasis	13
Proteomics-based receptor-ligand matching enhances differentiation maturity of human-stem-cell-derived neurons	13
PI3Kβ-regulated β-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression	13
Activation of canonical Wnt signaling is required for efficient direct reprogramming into human hepatic progenitor cells	13
The urgent need for clear and concise regulations on exosome-based interventions	13
AT7867 promotes pancreatic progenitor differentiation of human iPSCs	13
Targeting CCDC90B restores intestinal stem cell function under hyperuricemic stress	13
Safe CNV removal is crucial for successful hESC-RPE transplantation in wet age-related macular degeneration	13
CD37 regulates the self-renewal of leukemic stem cells via integrin-mediated signaling in acute myeloid leukemia	13