OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Orthopaedic Translation is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Treatment of tibial plateau fractures: A comparison of two different operation strategies with medium-term follow up	159
Epidemiological profiles and intervention strategies of limb deformities in China: A nationwide study based on the largest orthopedic database in China	132
From polarity to pathology: Decoding the role of cell orientation in osteoarthritis	84
Regulation of mitochondrial dynamic equilibrium by physical exercise in sarcopenia: A systematic review	69
Protective effects of irisin in sarcopenia: a promising treatment	66
Histone modifications: Unveiling the epigenetic enigma of degenerative skeletal diseases	63
Metformin prevents mandibular bone loss in a mouse model of accelerated aging by correcting dysregulated AMPK-mTOR signaling and osteoclast differentiation	62
Biomimicking design of artificial periosteum for promoting bone healing	59
Clinical and omics biomarkers in osteoarthritis diagnosis and treatment	58
Near-infrared smart responsive orthopedic implants with synergistic antimicrobial and bone integration-promoting properties	47
Targeting Piezo1 channel to alleviate intervertebral disc degeneration	46
Txnip regulates glycolysis and tricarboxylic acid cycle balance to maintain bone homeostasis	45
Capability of auxetic femoral stems to reduce stress shielding after total hip arthroplasty	43
Internal fixation with biodegradable high purity magnesium screws in the treatment of ankle fracture	41
CEST MRI: Translational prospects for intervertebral disc degeneration – from basic research to clinical applications	40
Niobium promotes fracture healing in rats by regulating the PI3K-Akt signalling pathway: An in vivo and in vitro study	39
Revisiting osteoarthritis pathogenesis through the lens of cGAS-STING: Mitochondrial damage, pyroptosis, and inflammatory cascades	39
Targeting MAT2A synergistically induces DNA damage in osteosarcoma cells through EZH2-mediated H3K27me3 modification	37
Forkhead box O3 attenuates osteoarthritis by suppressing ferroptosis through inactivation of NF-κB/MAPK signaling	37
Teriparatide ameliorates articular cartilage degradation and aberrant subchondral bone remodeling in DMM mice	35
Addressing musculoskeletal diseases by exploring the potentials of stem cells and plant-derived chemicals	34
2023 January issue Journal of Orthopaedic Translation	34
A perspective on reoperations after surgical treatments of degenerative lumbar diseases	33
Exosomes from umbilical cord mesenchymal stem cells ameliorate intervertebral disc degeneration via repairing mitochondrial dysfunction	33
Advances in experimental models of osteonecrosis of the femoral head	32

Foot and ankle biomaterials: a comprehensive review of current applications, challenges, and future directions	32
RO5126766 attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through mediating the ERK pathway	31
TRIM59 alleviates neuronal ferroptosis and promotes functional recovery after spinal cord injury by mediating ubiquitination and degradation of ANXA2	31
Does the regulation of skeletal muscle influence cognitive function? A scoping review of pre-clinical evidence	30
Targeting synovial inflammation in knee osteoarthritis: translational insights for diagnosis and therapy	30
Specific microRNAs are associated with fracture healing phases, patient age and multi-trauma	29
Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4 versus Aggrecan transgene in mice	29
Triptolide attenuates inhibition of ankylosing spondylitis-derived mesenchymal stem cells on the osteoclastogenesis through modulating exosomal transfer of circ-0110634	29
Organoids and organs-on-chips for accelerating R&D and clinical translation in Orthopaedics: Emerging opportunities and regulatory pathways	29
Corrigendum to ‘Guideline for adolescent scoliosis screening in China (Public Version 2024)’ [J Orthop Translation, Volume 50, January 2025, Pages 364-372]	28
Corrigendum to ‘JD-312 – A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression’[Journal of Orthopaedic Translation 44 (2024) 60–71]	28
Spatially resolved single-cell-based histocytomorphometry for growth plate analysis across multiple species	28
From scientific discovery to orthopaedic clinical innovation	28
Stress stimulation maintaining by genipin crosslinked hydrogel promotes annulus fibrosus healing	27
Stem cell-based therapeutic strategies for rotator cuff tendinopathy	27
Development of a standardized and reproducible murine femoral distraction osteogenesis model	27
Gut-bone axis perturbation: Mechanisms and interventions via gut microbiota as a primary driver of osteoporosis	27
Porous metal materials for applications in orthopedic field: A review on mechanisms in bone healing	27
Epigenetic reprogramming via EZH2 inhibition rescues fibroadipose pathogenesis in secondary lymphedema through activating PPARγ signaling	26
The Revolution of exosomes: From biological functions to therapeutic applications in skeletal muscle diseases	26
RETRACTED: Regulating inflammation microenvironment and tenogenic differentiation as sequential therapy promotes tendon healing in diabetic rats	26
Artificial ligaments in anterior cruciate ligament reconstruction: Coating strategies for PET-based materials	26
Evaluation of biological performance of 3D printed trabecular porous tantalum spine fusion cage in large animal models	26
The novel magnesium–titanium hybrid cannulated screws for the treatment of vertical femoral neck fractures: Biomechanical evaluation	25
Insights into predicting residual plate bending in vivo using sensor-informed finite element models	25
Establishment and characterization of an inflammatory cartilaginous organoids model for organoid transplantation study	25
Commentary: “Baicalein mediates the anti-tumor activity in Osteosarcoma through lncRNA-NEF driven Wnt/β-catenin signaling regulatory axis”	25
Scoliosis assessment tools to reduce follow-up X-rays	25
Bone microarchitecture assessed by 3D high-resolution peripheral quantitative computed tomography (HR-pQCT) as predictor of fracture risk in patients with glucocorticoid-induced osteoporosis	25
Daily low-intensity pulsed ultrasound stimulation mitigates joint degradation and pain in a post-traumatic osteoarthritis rat model	25
Moderate static magnetic field regulates iron metabolism and salvage bone loss caused by iron accumulation	24
GPX4 activator enhances neuroprotection and functional recovery in spinal cord injury	24
Strontium zinc silicate simultaneously alleviates osteoporosis and sarcopenia in tail-suspended rats via Piezo1-mediated Ca2+ signaling	24
Narirutin mitigates inflammatory arthritis and osteoporosis through modulating macrophage phenotype and osteoclastogenesis	24
Modular de- and re-construction of vascularized osteochondral tissues in an Organ-on-Chip dual-compartment platform	24
Eurycomanone stimulates bone mineralization in zebrafish larvae and promotes osteogenic differentiation of mesenchymal stem cells by upregulating AKT/GSK-3β/β-catenin signaling	24
Cerebrospinal fluid-derived extracellular vesicles after spinal cord injury promote vascular regeneration via PI3K/AKT signaling pathway	23
Regenerative strategies for intervertebral disc degeneration	23
RhoA deficiency in chondrocyte inhibits cartilage fibrosis and ameliorates osteoarthritis progression via SOX4/MMP2 axis	23
Vitamin D deficiency and disease conditions relevant to: Orthopaedic translation	23
Letter to the editor regarding “Promotion of bone-tendon healing after ACL reconstruction using scaffold-free constructs comprising ADSCs produced by a bio-3D printer in rabbit models”	22
COVID-19 hip fracture outcomes: The role of Ct values and D-dimer levels?	22
Epigenetic transcriptional regulation of skeletal aging: The emerging role of m6A methylation	22
An innovative self-stabilised 3D-printed artificial vertebral body designed for clinical application and comparison with the conventional implants	22
A novel precision micro-drilling technique for treating osteochondral lesions of the talus with superior cartilage regeneration and early rehabilitation compared with microfracture: a randomized contr	22
Salivary nitrate prevents osteoporosis via regulating bone marrow mesenchymal stem cells proliferation and differentiation	22
Gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via Fos in intervertebral disc degeneration	22
PINK1-mediated mitophagy contributes to glucocorticoid-induced cathepsin K production in osteocytes	21
Cell-based therapies for intervertebral disc degeneration: Navigating the path from promise to clinical reality	21
Combination of cobalt, chromium and titanium nanoparticles increases cytotoxicity in vitro and pro-inflammatory cytokines in vivo	20

Ubiquitination and deubiquitination: Implications for the pathogenesis and treatment of osteoarthritis	20
Tibial cortex transverse transport regulates Orai1/STIM1-mediated NO release and improve the migration and proliferation of vessels via increasing osteopontin expression	20
Relieving oxidative stress microenvironment and promoting vascularized bone formation to treat femoral head necrosis using 3D-printed scaffold with ultralong-term multienzyme-like activity	19
Dynamic finite element analyses to compare the influences of customised total talar replacement and total ankle arthroplasty on foot biomechanics during gait	19
Mitochondrial Transplantation/Transfer: Promising Therapeutic Strategies for Spinal Cord Injury	19
Melatonin suppresses bone marrow adiposity in ovariectomized rats by rescuing the imbalance between osteogenesis and adipogenesis through SIRT1 activation	19
From “academic success” to “commercial success” —The model of medical device translation driven by SCI articles	18
Bone marrow-derived myeloid cells drive neuroinflammation in Alzheimer's disease: Insights from the FAD4T mouse model	18
Sustained BMP-2 delivery via alginate microbeads and polydopamine-coated 3D-Printed PCL/β-TCP scaffold enhances bone regeneration in long bone segmental defects	18
Activation of α2-adrenergic receptors as a therapeutic strategy for immune rejection in post-surgery osteosarcoma recurrence treatment	18
Electric currents in disc health: The role of ion channels in intervertebral disc pathophysiology	18
Addressing musculoskeletal disorders through new treatment strategies	18
The role of Piezo1 in bone marrow stem cells in response to elevated intraosseous pressure on regulating osteogenesis and angiogenesis of steroid-induced osteonecrosis of the femoral head	18
Fibrocartilage hyalinization: A potential therapeutic strategy for articular fibrocartilage	18
Zhuangyao Jianshen Wan ameliorates senile osteoporosis in SAMP6 mice through Modulation of the GCN5L1-mediated PI3K/Akt/wnt signaling pathway	18
Establishment of a clinically relevant beagle model for periprosthetic joint infection with 3D-printed prostheses and multimodal evaluation	18
Pyroptosis-related crosstalk in osteoarthritis: Macrophages, fibroblast-like synoviocytes and chondrocytes	17
Randomized control trial of mesenchymal stem cells versus hyaluronic acid in patients with knee osteoarthritis – A Hong Kong pilot study	17
A static magnetic field enhances the repair of osteoarthritic cartilage by promoting the migration of stem cells and chondrogenesis	17
Antibiotic-free antimicrobial functionalization of PEEK via UV-induced self-initiation and N-halamine grafting	17
Correlations between paraspinal extensor muscle endurance and clinical outcomes in preoperative LSS patients and clinical value of an endurance classification	17
Role of oxidative stress in mitochondrial dysfunction and their implications in intervertebral disc degeneration: Mechanisms and therapeutic strategies	17
Naringin inhibits the osteoblast-osteoclast pyroptosis cascade reaction mediated by accumulated bone marrow adipose tissue in the treatment of postmenopausal osteoporosis	16
Three-dimensional distribution of subchondral fracture lines in osteonecrosis of the femoral head	16
Dihydroartemisinin ameliorates hemarthrosis-induced cartilage degeneration by suppressing chondrocyte senescence via activation of Keap1-Nrf2 signaling pathway	16
Deer antler polypeptides promote osteogenesis for fracture healing via activating neurosensory PGE2/EP4/p-CREB axis	16
Implants coating strategies for antibacterial treatment in fracture and defect models: A systematic review of animal studies	16
The brain–gut–joint axis in arthritis: crosstalk, treatment, and future perspectives	16
Engineering multifunctional microspheres for sequential regulation of osteoimmune microenvironment and bone remodeling balance to promote regeneration of osteoporotic bone defects	16
Targeting ANT1 to regulate PINK1/Parkin-mediated mitophagy is an effective treatment of trauma-induced tendon heterotopic ossification	16
Gut microbiota and bone aging: Focusing on the gut-X axis modes	16
Brain–bone axis dysregulation: Biological code underlying the bidirectional association between depression and musculoskeletal disorders	16
AMPK activator decelerates osteoarthritis development by inhibition of β-catenin signaling in chondrocytes	15
Inhibition of ERK1/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells	15
Ferroptosis-mediated immune responses in osteoporosis	15
Four-year comparative analysis of return to sport and psychological recovery following ACL revision: Artificial ligament vs. anterior tibial tendon allograft	15
Evaluation of testosterone and alendronate coated membranes in osteoporotic fracture and defect model in rats and goats	15
Tristetraprolin protects against osteoarthritis by restraining chondrocyte mitochondrial DNA release through post-transcriptional regulation	15
Bridging basic science and clinical practice in orthopaedic translational research	15
Autologous osteoperiosteal transplantation achieves comparable repair effect and superior interface integration to autologous osteochondral transplantation in porcine osteochondral defects	15
Design of internal fixation implants for fracture: A review	15
T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration	14
Targeting the glial-fibrotic scar microenvironment after spinal cord injury: From integrated protection to systematic regulation of regenerative balance	14
Stevioside attenuates osteoarthritis via regulating Nrf2/HO-1/NF-κB pathway	14
Evaluation of interbody fusion efficacy and biocompatibility of a polyetheretherketone/calcium silicate/porous tantalum cage in a goat model	14
Mechanistic insights into cartilage-sensory nerve crosstalk in osteoarthritis progression	14
The effect of local sympatholysis on bone-tendon interface healing in a murine rotator cuff repair model	14
Harnessing the potential of hyaluronic acid methacrylate (HAMA) hydrogel for clinical applications in orthopaedic diseases	14
Comment on: “Failure analysis and design improvement of retrieved plates from revision surgery”	14
Sargassum polysaccharide attenuates osteoarthritis in rats and is associated with the up-regulation of the ITGβ1-PI3K-AKT signaling pathway	14
Chronic pain after spine surgery: Insights into pathogenesis, new treatment, and preventive therapy	14
Myotendinous Junction development and repair	14
Corrigendum to ‘N6-methyladenosine and intervertebral disc degeneration: Advances in detection and pathological insights’ [J Orthop Translat 53 (2025) 38–51/JOT 941]	14
Redefining orthopaedic translation: Harnessing multi-omics, smart biomaterials, and regenerative immunomodulation	14
Risk-stratified lifetime risk and incidence of hip fracture and falls in middle-aged and elderly Chinese population: The China health and retirement longitudinal study	14
Augmenting osteoporotic osseointegration through a temporal release nanocoating-based reversing dysregulated osteogenic microenvironment	14
SPARCL1 promotes chondrocytes extracellular matrix degradation and inflammation in osteoarthritis via TNF/NF-κB pathway	14
1–2 T static magnetic field combined with Ferumoxytol prevent unloading-induced bone loss by regulating iron metabolism in osteoclastogenesis	14
Gallic acid mediates tumor-suppressive effects on osteosarcoma through the H19-Wnt/β-catenin regulatory axis	14
The involvement of signaling pathways in the pathogenesis of osteoarthritis: An update	14
Phillygenin inhibits neuroinflammation and promotes functional recovery after spinal cord injury via TLR4 inhibition of the NF-κB signaling pathway	13
Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-β/Smad signaling in a growing mouse model of osteogenesis imperfecta	13
Cycloastragenol prevents bone loss via inhibiting osteoclast activity in glucocorticoid-induced osteonecrosis of the femoral head: An in vivo study	13
Asymmetrical paravertebral muscles fibrosis causes progression of adolescent idiopathic scoliosis via myostatin signalling in fibro-adipogenic progenitors	13
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate muscle atrophy via the miR-132-3p/FoxO3 axis	13
A scaffold-free cartilage construct fabricated using a bio 3D printer accelerates critical-size bone defect regeneration	13
Hydrogel adhesives with a hydrodynamically induced liquid–solid transition for annular fissure sealing and inflammation modulation following microdiscectomy	13
Promotion of bone-tendon healing after ACL reconstruction using scaffold-free constructs comprising ADSCs produced by a bio-3D printer in rabbit models	13
Comparative biomechanical analyses of lower cervical spine post anterior fusion versus intervertebral disc arthroplasty: A geometrically patient-specific poroelastic finite element investigation	13
Advancing medical device regulatory reforms for innovation, translation and industry development in China	13
Radiomics signature of osteoarthritis: Current status and perspective	13
Hip joint-preserving strategies for treating osteonecrosis of the femoral head: From nonoperative to operative procedures	13
Response to the letter to editor regarding “finite element analysis of subtalar joint arthroereisis on adult acquired flexible flatfoot deformity using customized sinus tarsi implant”	13
Immunoporosis: The hidden link between aging immune cells and bone fragility	13
LRP1 mitigates intervertebral disc degeneration by inhibiting endoplasmic reticulum stress through stabilizing the PPARγ	13
Current progress and trends in musculoskeletal research: Highlights of NSFC-CUHK academic symposium on bone and joint degeneration and regeneration	13
Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development	13