Life Sciences in Space Research

Article	Citations
Anthocyanin can improve the survival of rice seeds from solar light outside the international space station	34
Biofilm dynamics in space and their potential for sustainable space exploration – A comprehensive review	34
Organ dose equivalents of albedo protons and neutrons under exposure to large solar particle events during lunar human landing missions	31
IFC - Editorial Board	24
3D culture and cryopreservation/thawing strategy of human induced pluripotent stem cells for spaceflight experiments	23
The heavy ion-induced up-regulation of ZIP14 is mediated by the PKC Nrf2 pathway	20
Physiological safety and Multi-Tissue metabolic adaptation under a novel intermittent prolonged fasting regimen	18
Organ dose conversion factors for murine galactic cosmic ray irradiation	18
Challenges and innovations in food and water availability for a sustainable Mars colonization	17
IFC - Editorial Board	17
The case for anterior segment optical coherence tomography (AS-OCT) for the international space station and future planetary spaceflight: Clinical relevance and technical implementation	17
Reorganization of the mouse oocyte' cytoskeleton after cultivation under simulated weightlessness	16
RadLab: An open science resource for radiation studies relevant to human spaceflight	14
Results from the Radiation Assessment Detector on the International Space Station: Part 1, the Charged Particle Detector	14
A no-fault risk compensation approach for radiation risks incurred in space travel	12
Residual radiation risk disparities across sex and race or ethnic groups for lifetime never-smokers on lunar missions	11
From Antarctic regolith to lunar greenhouses: Mechanistic insights into Brassica rapa photosystem II dynamics for sustainable space agriculture	11
Renal macrostructural and hilar Doppler hemodynamic stability during a 7-day head-down tilt bed rest: an exploratory ultrasound-based study in humans under simulated microgravity	10
Domestication of radiation sensitive Caenorhabditis Elegans strains suitable for liquid culture systems in long-term space mission	10
Comprehensive omics strategies for space agriculture development	9
Optimizing autonomous artificial intelligence diagnostics for neuro-ocular health in space missions	9
Comparative study of methods for detecting extraterrestrial life in exploration mission of Mars and the solar system	9
Disparity in the effect of partial gravity simulated using a new apparatus on different rat hindlimb muscles	9
Analysis of suitable site candidates for Mars human habitat and life-support technologies based on in situ water resource utilization	9
Galactic cosmic ray environment predictions for the NASA BioSentinel Mission, part 2:Post-mission validation	9

BioKMS-HAG: A hierarchically guided biomedical and space science knowledge fine-grained mining system	9
Construction of microgravity biological knowledge graph and its applications in anti-osteoporosis drug prediction	9
Neuroprotective and neuromodulatory role of agmatine in mitigating simulated microgravity-induced cognitive and behavioral deficits in rats	9
Radiation environment on TGO Mars orbit during solar particle events in January–October 2024. Corresponding solar eruptions and GOES proton fluxes data	9
Behavior of simple closed ecological systems; lower nutrient concentrations allow longer persistence of grazer populations	9
High-throughput screening strategies for space-based radiation countermeasure discovery	8
The missing discipline in space health operations: Nursing as mission assurance	8
UHAB-1: Physiological responses to a 48-hour spaceflight analog mission underwater	8
Comprehensive exercise countermeasures for astronauts low back pain in microgravity: A scoping review	8
Digital twin modelling in microgravity: A framework for predictive and personalised space medicine	8
Study on primary physicochemical characteristics and nutrient adsorption of four plant cultivation substrates	7
The COSPAR Planetary Protection Policy for robotic missions to Mars: A review of current scientific knowledge and future perspectives	7
Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights	7
Accumulation of high-energy phosphates blocks the expression of mitochondrial biogenesis markers and slow-type myosin in soleus muscle under 24 hours of rat hindlimb suspension	7
The neurology of space flight; How does space flight effect the human nervous system?	7
Simulated microgravity altered the gene expression profiles and inhibited the proliferation of Kupffer cells in the early phase by downregulating LMO2 and EZH2	7
Transfer learning as an AI-based solution to address limited datasets in space medicine	7
Tissue-specific dose equivalents of secondary mesons and leptons during galactic cosmic ray exposures for mars exploration	7
Infrared spectroscopy reveals ethylene glycol is an anti-crystallizer in water mixed astrochemical ices	7
Recent progresses on space life science research in China	7
Involvement of KATANIN1, a microtubule-severing enzyme, in hypergravity-induced modification of growth anisotropy in Arabidopsis hypocotyls	7
A method to predict space radiation biological effectiveness for non-cancer effects following intense Solar Particle Events	7
Pinoresinol diglucoside alleviates hindlimb unloading-induced bone loss in mice	7
Impact of weightlessness on dynamic deformation and haemodynamic parameters of the heart	6
Medical countermeasures for the hematopoietic-subsyndrome of acute radiation syndrome in space	6
Results from the Radiation Assessment Detector on the International Space Station, Part 2: The fast neutron detector	6
Simulated space environmental factors of weightlessness, noise and low atmospheric pressure differentially affect the diurnal rhythm and the gut microbiome	6
IFC - Editorial Board	6
Effects of social isolation and galactic cosmic radiation on fine motor skills and behavioral performance	6
Microbes and nutrient shift in a Closed Aquatic Ecosystem (CAES) during four weeks of operation	6
Musculoskeletal degeneration in space: translational parallels with spaceflight-associated ocular pathology and surgical implications	6
Integrated spaceflight transcriptomic analyses and simulated space experiments reveal key molecular features and functional changes driven by space stressors in space-flown C. elegans	6
Small tissue chips with big opportunities for space medicine	6
Radiative transfer modeling of the low-mass proto-binary system, IRAS 4A1 and 4A2	6
Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading	6
Transcriptomics analyses reveal microgravity triggers estrogen synthesis amidst degeneration and aging in human ovarian granulosa cells	5
Sleep deprivation and glymphatic dysfunction: Perspectives on the risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)	5
IFC - Editorial Board	5
Approaching ocular risks during spaceflight with 3D printing: Technical strategies to protect astronaut vision	5
Evolving radiological protection guidelines for exploration-class missions	5
Simulated microgravity induces a time-dependent shift from autophagy to apoptosis in osteoblasts, validated by TSPO, ATG12, and BNIP3L expression in vivo	5
Impact of gravitational forces on Red Blood Cell dynamics in biofluid suspension	5
Parabolic flight as a research platform to investigate ophthalmic changes in microgravity	5
Reduced gravity effects on gait coordinative structures	5
Solid waste management and resource recovery during the 4-crew 180-day CELSS integrated experiment	5
IFC - Editorial Board	5
Oxidative decarboxylation of L-alanine on hematite: Implications for prebiotic chemistry in planetary environments	5
Active radiation measurements over one solar cycle with two DOSTEL instruments in the Columbus laboratory of the International Space Station	5
Nutrition-based interventions for mitigating space radiation-induced DNA damage: A systematic review and meta-analysis	5
Comparison of the particle flux measured by Liulin-MO dosimeter in ExoMars TGO science orbit with those calculated by models	4

Sleep deprivation and glymphatic system dysfunction as a risk factor for SANS during long-duration spaceflight	4
Effects of clinostat-based microgravity simulation on the growth and differentiation of cerebral organoids using a 3D-clinostat	4
RRx-001 and the “Right stuff”: Protection and treatment in outer space	4
IFC - Editorial Board	4
Goals and trends in space exploration: An overview of the panel on exploration sessions at the committee on space research general assembly 2024	4
Effects of neutron radiation on pharmaceuticals in deep space-like environments - general anesthesia in space	4
Insights into the effect of microgravity on phytopathogens and plant-associated microbes	4
Lower body negative pressure as a research tool and countermeasure for the physiological effects of spaceflight: A comprehensive review	4
Optimized experimentation for the WormChip cartridge enables lifelong tracking and high-content phenotyping of multi-strain C. elegans toward advanced space biology	4
IFC - Editorial Board	4
IFC - Editorial Board	4
IFC - Editorial Board	4
Cardiovascular adaptations in microgravity conditions	4
Parabolic flight as a space-flight analogon impacts angiogenesis and lipid metabolism	4
Synergistic effect of IL-4 and simulated microgravity on osteogenic differentiation of periosteal stem cells	4
Biomechanics of healthy subjects during exercise on a simulated vibration isolation and stabilization system	4
Space biological and human survival: Investigations into plants, animals, microorganisms and their components and bioregenerative life support systems	4
Advancements in health monitoring technologies for astronauts in deep space missions: A Review	4
Corrigendum to ‘RadLab: An open science resource for radiation studies relevant to human spaceflight’ Life Sciences in Space Research Volume 43, November 2024, Pages 29-34	4
Leveraging lower body negative pressure for enhanced outcomes in orthopedic arthroplasty—Insights from NASA’s bone health research	4
Bone deconditioning during partial weight-bearing in rodents – A systematic review and meta-analysis	3
Comparative analysis of brassica rapa var. cymosa grown in hydroponic condition, lunar maria, and lunar highland regolith simulants: biochemical profiling and effects on drosophila melanogaster as an	3
Meter-scale 2D clinostats uncover environmentally derived variation in tomato responses to simulated microgravity	3
Caffeine consumption aboard the International Space Station and its relationship to sleep and cognitive performance	3
Space station and spacecraft environmental conditions and human mental health: Specific recommendations and guidelines	3
Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model	3
Comparative analysis of the molecular response characteristics in Platycodon grandiflorus irradiated with heavy ion beams and X-rays	3
Differential regulation of mitochondrial quality control in skeletal muscle by HZE radiation exposure and partial weightbearing in mice	3
Contemporary review of dermatologic conditions in space flight and future implications for long-duration exploration missions	3
An emerging paradigm for scientific decision: the AI evaluation of space science projects	3
Treatment with a superoxide dismutase mimetic for joint preservation during 35 and 75 days in orbit aboard the international space station, and after 120 days recovery on Earth	3
How do we transport plant species with desiccation-sensitive germplasm in space?	3
Automated pupillometry in space neuroscience	3
Non-targeted effects and space radiation risks for astronauts on multiple International Space Station and lunar missions	3
The influence of simulated weightlessness on the composition and function of gut microbiota and bile acid metabolism products	3
High throughput screen of small molecules as potential countermeasures to galactic cosmic radiation induced cellular dysfunction	3
The mechanism and protection of microgravity induced cardiac remodeling	3
Effects of social isolation alone and combined with15cGy GCRsim Space radiation on fear conditioned behavioral, stress and sleep responses	2
HERA: A Timepix-based radiation detection system for Exploration-class space missions	2
The brain-eye-liver axis during spaceflight: implications of hepatic dysfunction in spaceflight associated neuro-ocular syndrome	2
Development of a NASA roadmap for planetary protection to prepare for the first human missions to Mars	2
International space station external radiation field as measured by Liulin-SET spectrometer of ARMAS flight module 9 in September - October 2022	2
Space radiation measured during first-ever commercial suborbital mission on Virgin Galactic SpaceShipTwo Unity on 29 June 2023	2
Dose and LET-dependence of gastric cancer risk in Apc1638N/+ mice exposed to space-relevant radiation types	2
Changes of iron dynamics in the duodenum and bone marrow under partial gravity condition in mice	2
Spaceflight Reshapes the Gut Microbiome: Impact of Microgravity and Radiation on Dysbiosis-Associated Oncogenic Pathways	2
Harnessing nucleic acid technologies for human health on earth and in space	2
An ensemble dose-response model for monoenergetic ions and doses relevant for space radiation carcinogenesis	2
Simulated Microgravity affects immune reaction to infection through altering lymphocyte differentiation, cytokine secretion, and macrophage polarization	2
Weighing the impact of microgravity on vestibular and visual functions	2
Space radiation and risk for ocular surface malignancies: Exposure risk, current mitigation strategies, and management considerations for a mission to Mars	2
The COSPAR planetary protection policy for missions to Icy Worlds: A review of history, current scientific knowledge, and future directions	2
Molecular and biomechanical changes of the cornea and lens in spaceflight	2
Food technologies for space missions	2
Integrated analysis of miRNAome and transcriptome reveals that microgravity induces the alterations of critical functional gene modules via the regulation of miRNAs in short-term space-flown C. elegan	2
The ocular surface during spaceflight: Post-mission symptom report, extraterrestrial risks, and in-flight therapeutics	2
IFC - Editorial Board	2
Dose-specific lncRNA–mRNA networks modulate DNA damage and immune responses in CD4⁺ T cells under simulated space UVC irradiation	2
Exploring microgravity-induced changes to the coagulation system using thrombelastograph - a topical review	2
A multilevel probabilistic dose response model for radiation-induced Harderian gland tumor prevalence–single beam and mixed field effects	2
Combined irradiation by gamma-rays and carbon-12 nuclei caused hyperlocomotion and change in striatal metabolism of rats	2
Biophysics of ophthalmic medications during spaceflight: Principles of ocular fluid dynamics and pharmacokinetics in microgravity	2
Celestial hazards: immunological and pulmonary effects of lunar and Martian regolith simulants	2
Increase in steryl glycoside levels and stimulation of lipid raft formation in azuki bean epicotyls under hypergravity conditions	2
Damage to human gastric epithelial cells induced by the microgravity effect and intervention strategy based on magnesium ascorbyl phosphate	2
Microgravity as a contributing factor to venous thromboembolism development: Risks and prevention strategies	1
Gypsophytes and the use of Martian Gypsum: A review of their potential for agriculture on Mars	1
Compact portable sources of high-LET radiation: Validation and potential application for galactic cosmic radiation countermeasure discovery	1
Goldfish regenerated scale culture at low temperatures improves osteoblast and osteoclast survival in scales without loss of the osteoblast and osteoclast response to changes in gravity	1
A systematic review of plant cultivation and growth in extraterrestrial regolith simulants	1
Galactic cosmic ray simulation at the NASA space radiation laboratory – Progress, challenges and recommendations on mixed-field effects	1
Protective effect of Gastrodia elata blume ameliorates simulated weightlessness-induced cognitive impairment in mice	1
Astrochemistry: The study of chemical processes in space	1
In Memoriam	1
Cultivation and synthesis of food for humans beyond earth: A future view	1
DNA decompaction enhances the formation of radiation-induced DNA double strand breaks and chromosome aberrations	1
The COSPAR planetary protection requirements for space missions to Venus	1
Characterization of virulence-related phenotypes of Candida parapsilosis and Rhodotorula mucilaginosa isolated from the International Space Station (ISS)	1
Decoupling musculoskeletal integrity in microgravity: Molecular drivers and therapeutic horizons	1
The microwave electromagnetic background as measured onboard the International Space Station	1

Stability of ice-embedded glycine under space ionizing radiations: a RT-TD-DFT and DFT study	1
Effects of preexposure to a subthreshold dose of helium particles on the changes in performance produced by exposure to helium particles	1
3D bioprinting meniscus tissue onboard the International Space Station	1
Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects	1
Hybrid active-passive galactic cosmic ray simulator: Experimental implementation and microdosimetric characterization	1
Applications of the ocular trauma score (OTS) as a framework for spaceflight related ocular trauma (SROT) triage and management	1
Non-DNA radiosensitive targets that initiate persistent behavioral deficits in rats exposed to space radiation	1
Neurostimulation as a technology countermeasure for dry eye syndrome in astronauts	1
Artificial gravity during spaceflight prevents gait and performance deficits in a gravity-dose dependent manner	1
Considerations for carcinogenesis countermeasure development using mouse models	1
Amorphous calcium carbonate enhances osteogenic differentiation and myotube formation of human bone marrow derived mesenchymal stem cells and primary skeletal muscle cells under microgravity condition	1
Human thermoregulation in microgravity environments: Insights from a computational model	1
Corrigendum to “Characterization of virulence-related phenotypes of Candida parapsilosis and Rhodotorula mucilaginosa isolated from the International Space Station (ISS)” [Life Sciences in Space Resea	1
Effects of hypobaria, hyperoxia, and nitrogen form on the growth and nutritional quality of lettuce	1
Cultivation and nutritional characteristics of Chlorella vulgaris cultivated using Martian regolith and synthetic urine	1
Dose measurements with the Pille-ISS thermoluminescent dosimeter system during extravehicular activities (2004-2022)	1
Analysis of the reaction of cosmonaut's body microcirculatory-tissue systems to postural effects at tilt-table	1
Exploring phytomedicine in space medicine: Addressing health challenges in microgravity	1
Palmer Station, Antarctica: A ground-based spaceflight analog suitable for validation of biomedical countermeasures for deep space missions	1
Short-term 6° head-down tilt bed rest simulating microgravity ameliorates blood pressure and heart rate variability: A quasi-experimental study on healthy adults	1
Advanced food packaging systems for space exploration missions	1
Modelling of the neutron and light-ion components of the field inside the International Space Station: Support for PADC neutron dose measurements within the HAMLET project	1
Effects of X-ray irradiation and housing conditions on mitochondria in Peromyscus maniculatus	1
Carbonate precipitation and nitrogen fixation in AMG (Artificial Martian Ground) by cyanobacteria	1
Reduced set-shifting processing speed in male rats following low dose (10 cGy) proton exposure	1
Dynamic visual acuity as a biometric for astronaut performance and safety	1
Counteracting inactivity deconditioning with graded hypergravity loading: From clinical neurorehabilitation to space medicine	1
Decreased myocardial glucose uptake precedes cardiac dysfunction in hindlimb unloading mice revealed by dynamic 18F-FDG PET imaging	1
Active responses of cyanobacterial crusts directly exposed to the extreme stratospheric environment	1
Exposing Drosophila to wheat-derived microbes enhances its immunity and survival under simulated microgravity	1
Tryptophan metabolites are altered when Caco-2 cells are exposed to simulated microgravity	1
The effect of Hydrogen-rich water on retinal degeneration in the outer nuclear layer of simulated weightlessness rats	1
Radiation cataract in Heterogeneous Stock mice after γ-ray or HZE ion exposure	1
Hydroponics for plant cultivation in space – a white paper	1
Leaf yield and mineral content of mizuna in response to cut-and-come-again harvest, substrate particle size, and fertilizer formulation in a simulated spaceflight environment	1
Analytical calculation of the dose to a spherical target by an ion at almost all impact parameters, and calculation of the energy deposition spectra	1
Recent observational studies on carbon-chain species with current facilities and future prospects with ALMA & JWST	1