Life Sciences in Space Research

Article	Citations
Anthocyanin can improve the survival of rice seeds from solar light outside the international space station	34
The heavy ion-induced up-regulation of ZIP14 is mediated by the PKC Nrf2 pathway	33
IFC - Editorial Board	31
Physiological safety and Multi-Tissue metabolic adaptation under a novel intermittent prolonged fasting regimen	24
Challenges and innovations in food and water availability for a sustainable Mars colonization	24
Biofilm dynamics in space and their potential for sustainable space exploration – A comprehensive review	21
Organ dose conversion factors for murine galactic cosmic ray irradiation	19
3D culture and cryopreservation/thawing strategy of human induced pluripotent stem cells for spaceflight experiments	18
Organ dose equivalents of albedo protons and neutrons under exposure to large solar particle events during lunar human landing missions	18
From Antarctic regolith to lunar greenhouses: Mechanistic insights into Brassica rapa photosystem II dynamics for sustainable space agriculture	18
Reorganization of the mouse oocyte' cytoskeleton after cultivation under simulated weightlessness	17
A no-fault risk compensation approach for radiation risks incurred in space travel	17
The case for anterior segment optical coherence tomography (AS-OCT) for the international space station and future planetary spaceflight: Clinical relevance and technical implementation	17
Results from the Radiation Assessment Detector on the International Space Station: Part 1, the Charged Particle Detector	16
Residual radiation risk disparities across sex and race or ethnic groups for lifetime never-smokers on lunar missions	16
RadLab: An open science resource for radiation studies relevant to human spaceflight	14
IFC - Editorial Board	13
Domestication of radiation sensitive Caenorhabditis Elegans strains suitable for liquid culture systems in long-term space mission	11
Renal macrostructural and hilar Doppler hemodynamic stability during a 7-day head-down tilt bed rest: an exploratory ultrasound-based study in humans under simulated microgravity	11
Comprehensive omics strategies for space agriculture development	11
Analysis of suitable site candidates for Mars human habitat and life-support technologies based on in situ water resource utilization	10
Radiation environment on TGO Mars orbit during solar particle events in January–October 2024. Corresponding solar eruptions and GOES proton fluxes data	10
Construction of microgravity biological knowledge graph and its applications in anti-osteoporosis drug prediction	9
Behavior of simple closed ecological systems; lower nutrient concentrations allow longer persistence of grazer populations	9
BioKMS-HAG: A hierarchically guided biomedical and space science knowledge fine-grained mining system	9

Optimizing autonomous artificial intelligence diagnostics for neuro-ocular health in space missions	9
Comparative study of methods for detecting extraterrestrial life in exploration mission of Mars and the solar system	9
Disparity in the effect of partial gravity simulated using a new apparatus on different rat hindlimb muscles	9
Galactic cosmic ray environment predictions for the NASA BioSentinel Mission, part 2:Post-mission validation	9
Study on primary physicochemical characteristics and nutrient adsorption of four plant cultivation substrates	9
Neuroprotective and neuromodulatory role of agmatine in mitigating simulated microgravity-induced cognitive and behavioral deficits in rats	9
High-throughput screening strategies for space-based radiation countermeasure discovery	8
Digital twin modelling in microgravity: A framework for predictive and personalised space medicine	8
The neurology of space flight; How does space flight effect the human nervous system?	8
Recent progresses on space life science research in China	8
Comprehensive exercise countermeasures for astronauts low back pain in microgravity: A scoping review	8
UHAB-1: Physiological responses to a 48-hour spaceflight analog mission underwater	8
Infrared spectroscopy reveals ethylene glycol is an anti-crystallizer in water mixed astrochemical ices	7
Simulated microgravity altered the gene expression profiles and inhibited the proliferation of Kupffer cells in the early phase by downregulating LMO2 and EZH2	7
Impact of weightlessness on dynamic deformation and haemodynamic parameters of the heart	7
Pinoresinol diglucoside alleviates hindlimb unloading-induced bone loss in mice	7
Integrated spaceflight transcriptomic analyses and simulated space experiments reveal key molecular features and functional changes driven by space stressors in space-flown C. elegans	7
The COSPAR Planetary Protection Policy for robotic missions to Mars: A review of current scientific knowledge and future perspectives	7
Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights	7
Transfer learning as an AI-based solution to address limited datasets in space medicine	7
Accumulation of high-energy phosphates blocks the expression of mitochondrial biogenesis markers and slow-type myosin in soleus muscle under 24 hours of rat hindlimb suspension	7
The missing discipline in space health operations: Nursing as mission assurance	7
Involvement of KATANIN1, a microtubule-severing enzyme, in hypergravity-induced modification of growth anisotropy in Arabidopsis hypocotyls	7
Tissue-specific dose equivalents of secondary mesons and leptons during galactic cosmic ray exposures for mars exploration	7
A method to predict space radiation biological effectiveness for non-cancer effects following intense Solar Particle Events	7
Simulated space environmental factors of weightlessness, noise and low atmospheric pressure differentially affect the diurnal rhythm and the gut microbiome	6
Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading	6
Effects of social isolation and galactic cosmic radiation on fine motor skills and behavioral performance	6
Medical countermeasures for the hematopoietic-subsyndrome of acute radiation syndrome in space	6
Results from the Radiation Assessment Detector on the International Space Station, Part 2: The fast neutron detector	6
IFC - Editorial Board	6
Radiative transfer modeling of the low-mass proto-binary system, IRAS 4A1 and 4A2	6
Musculoskeletal degeneration in space: translational parallels with spaceflight-associated ocular pathology and surgical implications	6
Small tissue chips with big opportunities for space medicine	6
IFC - Editorial Board	6
Microbes and nutrient shift in a Closed Aquatic Ecosystem (CAES) during four weeks of operation	6
Solid waste management and resource recovery during the 4-crew 180-day CELSS integrated experiment	5
Reduced gravity effects on gait coordinative structures	5
Impact of gravitational forces on Red Blood Cell dynamics in biofluid suspension	5
Transcriptomics analyses reveal microgravity triggers estrogen synthesis amidst degeneration and aging in human ovarian granulosa cells	5
Sleep deprivation and glymphatic dysfunction: Perspectives on the risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)	5
IFC - Editorial Board	5
Oxidative decarboxylation of L-alanine on hematite: Implications for prebiotic chemistry in planetary environments	5
Simulated microgravity induces a time-dependent shift from autophagy to apoptosis in osteoblasts, validated by TSPO, ATG12, and BNIP3L expression in vivo	5
IFC - Editorial Board	5
Cardiovascular adaptations in microgravity conditions	5
Approaching ocular risks during spaceflight with 3D printing: Technical strategies to protect astronaut vision	5
Parabolic flight as a research platform to investigate ophthalmic changes in microgravity	5
Evolving radiological protection guidelines for exploration-class missions	5
Nutrition-based interventions for mitigating space radiation-induced DNA damage: A systematic review and meta-analysis	5

Parabolic flight as a space-flight analogon impacts angiogenesis and lipid metabolism	5
Active radiation measurements over one solar cycle with two DOSTEL instruments in the Columbus laboratory of the International Space Station	5
Caffeine Consumption Aboard the International Space Station and its Relationship to Sleep and Cognitive Performance	4
Contemporary review of dermatologic conditions in space flight and future implications for long-duration exploration missions	4
A non-invasive approach to monitor anemia during long-duration spaceflight with retinal fundus images and deep learning	4
Synergistic effect of IL-4 and simulated microgravity on osteogenic differentiation of periosteal stem cells	4
Corrigendum to ‘RadLab: An open science resource for radiation studies relevant to human spaceflight’ Life Sciences in Space Research Volume 43, November 2024, Pages 29-34	4
Leveraging lower body negative pressure for enhanced outcomes in orthopedic arthroplasty—Insights from NASA’s bone health research	4
Biomechanics of healthy subjects during exercise on a simulated vibration isolation and stabilization system	4
Space biological and human survival: Investigations into plants, animals, microorganisms and their components and bioregenerative life support systems	4
Bone deconditioning during partial weight-bearing in rodents – A systematic review and meta-analysis	4
IFC - Editorial Board	4
Advancements in health monitoring technologies for astronauts in deep space missions: A Review	4
Goals and trends in space exploration: An overview of the panel on exploration sessions at the committee on space research general assembly 2024	4
Comparison of the particle flux measured by Liulin-MO dosimeter in ExoMars TGO science orbit with those calculated by models	4
Insights into the effect of microgravity on phytopathogens and plant-associated microbes	4
IFC - Editorial Board	4
The mechanism and protection of microgravity induced cardiac remodeling	4
How do we transport plant species with desiccation-sensitive germplasm in space?	4
Effects of clinostat-based microgravity simulation on the growth and differentiation of cerebral organoids using a 3D-clinostat	4
Sleep deprivation and glymphatic system dysfunction as a risk factor for SANS during long-duration spaceflight	4
Lower body negative pressure as a research tool and countermeasure for the physiological effects of spaceflight: A comprehensive review	4
IFC - Editorial Board	4
Effects of neutron radiation on pharmaceuticals in deep space-like environments - general anesthesia in space	4
IFC - Editorial Board	4
Differential regulation of mitochondrial quality control in skeletal muscle by HZE radiation exposure and partial weightbearing in mice	3
Automated pupillometry in space neuroscience	3
Treatment with a superoxide dismutase mimetic for joint preservation during 35 and 75 days in orbit aboard the international space station, and after 120 days recovery on Earth	3
The COSPAR planetary protection policy for missions to Icy Worlds: A review of history, current scientific knowledge, and future directions	3
Biophysics of ophthalmic medications during spaceflight: Principles of ocular fluid dynamics and pharmacokinetics in microgravity	3
Meter-scale 2D clinostats uncover environmentally derived variation in tomato responses to simulated microgravity	3
The influence of simulated weightlessness on the composition and function of gut microbiota and bile acid metabolism products	3
Non-targeted effects and space radiation risks for astronauts on multiple International Space Station and lunar missions	3
Dose and LET-dependence of gastric cancer risk in Apc1638N/+ mice exposed to space-relevant radiation types	3
Space station and spacecraft environmental conditions and human mental health: Specific recommendations and guidelines	3
Space radiation measured during first-ever commercial suborbital mission on Virgin Galactic SpaceShipTwo Unity on 29 June 2023	3
RRx-001 and the “Right stuff”: Protection and treatment in outer space	3
Comparative analysis of the molecular response characteristics in Platycodon grandiflorus irradiated with heavy ion beams and X-rays	3
Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model	3
An emerging paradigm for scientific decision: the AI evaluation of space science projects	3
Combined irradiation by gamma-rays and carbon-12 nuclei caused hyperlocomotion and change in striatal metabolism of rats	3
High throughput screen of small molecules as potential countermeasures to galactic cosmic radiation induced cellular dysfunction	3
Comparative analysis of brassica rapa var. cymosa grown in hydroponic condition, lunar maria, and lunar highland regolith simulants: biochemical profiling and effects on drosophila melanogaster as an	3
Weighing the impact of microgravity on vestibular and visual functions	2
A multilevel probabilistic dose response model for radiation-induced Harderian gland tumor prevalence–single beam and mixed field effects	2
Celestial hazards: immunological and pulmonary effects of lunar and Martian regolith simulants	2
Integrated analysis of miRNAome and transcriptome reveals that microgravity induces the alterations of critical functional gene modules via the regulation of miRNAs in short-term space-flown C. elegan	2
Decreased myocardial glucose uptake precedes cardiac dysfunction in hindlimb unloading mice revealed by dynamic 18F-FDG PET imaging	2
Harnessing nucleic acid technologies for human health on earth and in space	2
The brain-eye-liver axis during spaceflight: implications of hepatic dysfunction in spaceflight associated neuro-ocular syndrome	2
Effects of social isolation alone and combined with15cGy GCRsim Space radiation on fear conditioned behavioral, stress and sleep responses	2
Changes of iron dynamics in the duodenum and bone marrow under partial gravity condition in mice	2
Medial prefrontal cortex and hippocampus in mice differently affected by simulate microgravity and social isolation associated with the alternation of emotional and cognitive functions	2
Exploring microgravity-induced changes to the coagulation system using thrombelastograph - a topical review	2
Increase in steryl glycoside levels and stimulation of lipid raft formation in azuki bean epicotyls under hypergravity conditions	2
Development of a NASA roadmap for planetary protection to prepare for the first human missions to Mars	2
An ensemble dose-response model for monoenergetic ions and doses relevant for space radiation carcinogenesis	2
The ocular surface during spaceflight: Post-mission symptom report, extraterrestrial risks, and in-flight therapeutics	2
IFC - Editorial Board	2
Dose-specific lncRNA–mRNA networks modulate DNA damage and immune responses in CD4⁺ T cells under simulated space UVC irradiation	2
International space station external radiation field as measured by Liulin-SET spectrometer of ARMAS flight module 9 in September - October 2022	2
Food technologies for space missions	2
Space radiation and risk for ocular surface malignancies: Exposure risk, current mitigation strategies, and management considerations for a mission to Mars	2
Molecular and biomechanical changes of the cornea and lens in spaceflight	2
Simulated Microgravity affects immune reaction to infection through altering lymphocyte differentiation, cytokine secretion, and macrophage polarization	2
Damage to human gastric epithelial cells induced by the microgravity effect and intervention strategy based on magnesium ascorbyl phosphate	2
Human thermoregulation in microgravity environments: Insights from a computational model	2
HERA: A Timepix-based radiation detection system for Exploration-class space missions	2
Advanced food packaging systems for space exploration missions	1
Non-DNA radiosensitive targets that initiate persistent behavioral deficits in rats exposed to space radiation	1
Application of functional microbial agent in aerobic composting of wheat straw for waste recycling	1
Protective effect of Gastrodia elata blume ameliorates simulated weightlessness-induced cognitive impairment in mice	1
In Memoriam	1
Effects of X-ray irradiation and housing conditions on mitochondria in Peromyscus maniculatus	1
Reduced set-shifting processing speed in male rats following low dose (10 cGy) proton exposure	1
Decoupling Musculoskeletal Integrity in Microgravity: Molecular Drivers and Therapeutic Horizons	1
Hybrid active-passive galactic cosmic ray simulator: Experimental implementation and microdosimetric characterization	1
The microwave electromagnetic background as measured onboard the International Space Station	1
Corrigendum to “Characterization of virulence-related phenotypes of Candida parapsilosis and Rhodotorula mucilaginosa isolated from the International Space Station (ISS)” [Life Sciences in Space Resea	1
Recent observational studies on carbon-chain species with current facilities and future prospects with ALMA & JWST	1

Tryptophan metabolites are altered when Caco-2 cells are exposed to simulated microgravity	1
Effects of preexposure to a subthreshold dose of helium particles on the changes in performance produced by exposure to helium particles	1
Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects	1
Carbonate precipitation and nitrogen fixation in AMG (Artificial Martian Ground) by cyanobacteria	1
Characterization of virulence-related phenotypes of Candida parapsilosis and Rhodotorula mucilaginosa isolated from the International Space Station (ISS)	1
Cultivation and nutritional characteristics of Chlorella vulgaris cultivated using Martian regolith and synthetic urine	1
Considerations for carcinogenesis countermeasure development using mouse models	1
Amorphous calcium carbonate enhances osteogenic differentiation and myotube formation of human bone marrow derived mesenchymal stem cells and primary skeletal muscle cells under microgravity condition	1
Applications of the ocular trauma score (OTS) as a framework for spaceflight related ocular trauma (SROT) triage and management	1
Analytical calculation of the dose to a spherical target by an ion at almost all impact parameters, and calculation of the energy deposition spectra	1
Galactic cosmic ray simulation at the NASA space radiation laboratory – Progress, challenges and recommendations on mixed-field effects	1
Short-term 6° head-down tilt bed rest simulating microgravity ameliorates blood pressure and heart rate variability: A quasi-experimental study on healthy adults	1
Astrochemistry: The study of chemical processes in space	1
The effect of Hydrogen-rich water on retinal degeneration in the outer nuclear layer of simulated weightlessness rats	1
Counteracting inactivity deconditioning with graded hypergravity loading: From clinical neurorehabilitation to space medicine	1
Microgravity as a contributing factor to venous thromboembolism development: Risks and prevention strategies	1
Goldfish regenerated scale culture at low temperatures improves osteoblast and osteoclast survival in scales without loss of the osteoblast and osteoclast response to changes in gravity	1
Palmer Station, Antarctica: A ground-based spaceflight analog suitable for validation of biomedical countermeasures for deep space missions	1
Compact portable sources of high-LET radiation: Validation and potential application for galactic cosmic radiation countermeasure discovery	1
Cultivation and Synthesis of Food for Humans Beyond Earth: A Future View	1
3D bioprinting meniscus tissue onboard the International Space Station	1
Characteristics of blood plasma proteome changes associated with the hemorrhagic purpura of cosmonauts on the first day after long-term space missions	1
Radiation cataract in Heterogeneous Stock mice after γ-ray or HZE ion exposure	1
DNA decompaction enhances the formation of radiation-induced DNA double strand breaks and chromosome aberrations	1
Active responses of cyanobacterial crusts directly exposed to the extreme stratospheric environment	1
Effects of hypobaria, hyperoxia, and nitrogen form on the growth and nutritional quality of lettuce	1
Artificial gravity during spaceflight prevents gait and performance deficits in a gravity-dose dependent manner	1
Leaf yield and mineral content of mizuna in response to cut-and-come-again harvest, substrate particle size, and fertilizer formulation in a simulated spaceflight environment	1
A systematic review of plant cultivation and growth in extraterrestrial regolith simulants	1
Stability of ice-embedded glycine under space ionizing radiations: a RT-TD-DFT and DFT study	1
The COSPAR planetary protection requirements for space missions to Venus	1
Exposing Drosophila to wheat-derived microbes enhances its immunity and survival under simulated microgravity	1
Dynamic visual acuity as a biometric for astronaut performance and safety	1
Neurostimulation as a technology countermeasure for dry eye syndrome in astronauts	1
Gypsophytes and the use of Martian Gypsum: A review of their potential for agriculture on Mars	1