OOIR: Observatory of International Research

Papers

(The median citation count of Life Sciences in Space Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
IFC - Editorial Board	35
Effect of countermeasure bodygear on cardiac-vascular-respiratory coupling during 6-degree head-down tilt: An earth-based microgravity study	31
Biofilm dynamics in space and their potential for sustainable space exploration – A comprehensive review	28
Anthocyanin can improve the survival of rice seeds from solar light outside the international space station	27
Challenges and innovations in food and water availability for a sustainable Mars colonization	24
IFC - Editorial Board	23
Organ dose equivalents of albedo protons and neutrons under exposure to large solar particle events during lunar human landing missions	23
IFC - Editorial Board	21
Lignocellulose degradation, biogas production and characteristics of the microbial community in solid-state anaerobic digestion of wheat straw waste	20
Residual radiation risk disparities across sex and race or ethnic groups for lifetime never-smokers on lunar missions	19
The case for anterior segment optical coherence tomography (AS-OCT) for the international space station and future planetary spaceflight: Clinical relevance and technical implementation	19
RadLab: An open science resource for radiation studies relevant to human spaceflight	19
A no-fault risk compensation approach for radiation risks incurred in space travel	18
Reorganization of the mouse oocyte' cytoskeleton after cultivation under simulated weightlessness	17
Results from the Radiation Assessment Detector on the International Space Station: Part 1, the Charged Particle Detector	17
Analysis of suitable site candidates for Mars human habitat and life-support technologies based on in situ water resource utilization	16
Comparative study of methods for detecting extraterrestrial life in exploration mission of Mars and the solar system	16
Optimizing autonomous artificial intelligence diagnostics for neuro-ocular health in space missions	16
Radiation environment on TGO Mars orbit during solar particle events in January–October 2024. Corresponding solar eruptions and GOES proton fluxes data	16
Galactic cosmic ray environment predictions for the NASA BioSentinel Mission, part 2:Post-mission validation	16
Construction of microgravity biological knowledge graph and its applications in anti-osteoporosis drug prediction	15
Disparity in the effect of partial gravity simulated using a new apparatus on different rat hindlimb muscles	14
Behavior of simple closed ecological systems; lower nutrient concentrations allow longer persistence of grazer populations	14
The COSPAR Planetary Protection Policy for robotic missions to Mars: A review of current scientific knowledge and future perspectives	13
Infrared spectroscopy reveals ethylene glycol is an anti-crystallizer in water mixed astrochemical ices	13

Study on primary physicochemical characteristics and nutrient adsorption of four plant cultivation substrates	12
Recent progresses on space life science research in China	11
Transfer learning as an AI-based solution to address limited datasets in space medicine	10
The neurology of space flight; How does space flight effect the human nervous system?	10
A method to predict space radiation biological effectiveness for non-cancer effects following intense Solar Particle Events	10
High-throughput screening strategies for space-based radiation countermeasure discovery	10
Tissue-specific dose equivalents of secondary mesons and leptons during galactic cosmic ray exposures for mars exploration	9
Small tissue chips with big opportunities for space medicine	9
Integrated spaceflight transcriptomic analyses and simulated space experiments reveal key molecular features and functional changes driven by space stressors in space-flown C. elegans	9
Involvement of KATANIN1, a microtubule-severing enzyme, in hypergravity-induced modification of growth anisotropy in Arabidopsis hypocotyls	9
IFC - Editorial Board	9
Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading	9
Impact of weightlessness on dynamic deformation and haemodynamic parameters of the heart	9
Simulated microgravity altered the gene expression profiles and inhibited the proliferation of Kupffer cells in the early phase by downregulating LMO2 and EZH2	9
IFC - Editorial Board	9
Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights	9
Accumulation of high-energy phosphates blocks the expression of mitochondrial biogenesis markers and slow-type myosin in soleus muscle under 24 hours of rat hindlimb suspension	9
Effects of social isolation and galactic cosmic radiation on fine motor skills and behavioral performance	8
Simulated space environmental factors of weightlessness, noise and low atmospheric pressure differentially affect the diurnal rhythm and the gut microbiome	8
Medical countermeasures for the hematopoietic-subsyndrome of acute radiation syndrome in space	8
Microbes and nutrient shift in a Closed Aquatic Ecosystem (CAES) during four weeks of operation	8
Solid waste management and resource recovery during the 4-crew 180-day CELSS integrated experiment	7
Evolving radiological protection guidelines for exploration-class missions	7
Results from the Radiation Assessment Detector on the International Space Station, Part 2: The fast neutron detector	7
IFC - Editorial Board	7
Spaceflight validation of technology for point-of-care monitoring of peripheral blood WBC and differential in astronauts during space missions	7
Reduced gravity effects on gait coordinative structures	7
Parabolic flight as a research platform to investigate ophthalmic changes in microgravity	7
Active radiation measurements over one solar cycle with two DOSTEL instruments in the Columbus laboratory of the International Space Station	6
Parabolic flight as a space-flight analogon impacts angiogenesis and lipid metabolism	6
Lower body negative pressure as a research tool and countermeasure for the physiological effects of spaceflight: A comprehensive review	6
Cardiovascular adaptations in microgravity conditions	6
Leveraging lower body negative pressure for enhanced outcomes in orthopedic arthroplasty—Insights from NASA’s bone health research	6
Sleep deprivation and glymphatic dysfunction: Perspectives on the risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)	6
Mimic microgravity effect on muscle transcriptome under ionizing radiation	6
Comparison of the particle flux measured by Liulin-MO dosimeter in ExoMars TGO science orbit with those calculated by models	6
IFC - Editorial Board	6
Improving astronaut cancer risk assessment from space radiation with an ensemble model framework	6
Bone deconditioning during partial weight-bearing in rodents – A systematic review and meta-analysis	5
Automated pupillometry in space neuroscience	5
Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice	5
Biomechanics of healthy subjects during exercise on a simulated vibration isolation and stabilization system	5
Optimized crop growth area composition for long duration spaceflight	5
IFC - Editorial Board	5
Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model	5
Comparative analysis of the molecular response characteristics in Platycodon grandiflorus irradiated with heavy ion beams and X-rays	5
Effects of neutron radiation on pharmaceuticals in deep space-like environments - general anesthesia in space	5
Corrigendum to ‘RadLab: An open science resource for radiation studies relevant to human spaceflight’ Life Sciences in Space Research Volume 43, November 2024, Pages 29-34	5
IFC - Editorial Board	5
Contemporary review of dermatologic conditions in space flight and future implications for long-duration exploration missions	5

RRx-001 and the “Right stuff”: Protection and treatment in outer space	5
A non-invasive approach to monitor anemia during long-duration spaceflight with retinal fundus images and deep learning	5
IFC - Editorial Board	5
Sleep deprivation and glymphatic system dysfunction as a risk factor for SANS during long-duration spaceflight	5
Space biological and human survival: Investigations into plants, animals, microorganisms and their components and bioregenerative life support systems	5
Relationship of collagen as the component of the extracellular matrix with the mechanisms of autonomic regulation of the cardiovascular system under simulated conditions of long-term isolation	5
Space radiation measured during first-ever commercial suborbital mission on Virgin Galactic SpaceShipTwo Unity on 29 June 2023	4
Treatment with a superoxide dismutase mimetic for joint preservation during 35 and 75 days in orbit aboard the international space station, and after 120 days recovery on Earth	4
Space station and spacecraft environmental conditions and human mental health: Specific recommendations and guidelines	4
The influence of simulated weightlessness on the composition and function of gut microbiota and bile acid metabolism products	4
What can space radiation protection learn from radiation oncology?	4
The ocular surface during spaceflight: Post-mission symptom report, extraterrestrial risks, and in-flight therapeutics	4
Weighing the impact of microgravity on vestibular and visual functions	4
Non-targeted effects and space radiation risks for astronauts on multiple International Space Station and lunar missions	4
The lack of mass transfer in bone lacunar-canalicular system may be the decisive factor of osteoporosis under microgravity	4
Biophysics of ophthalmic medications during spaceflight: Principles of ocular fluid dynamics and pharmacokinetics in microgravity	4
Medial prefrontal cortex and hippocampus in mice differently affected by simulate microgravity and social isolation associated with the alternation of emotional and cognitive functions	4
Integrated analysis of miRNAome and transcriptome reveals that microgravity induces the alterations of critical functional gene modules via the regulation of miRNAs in short-term space-flown C. elegan	4
Changes of iron dynamics in the duodenum and bone marrow under partial gravity condition in mice	4
Development of a NASA roadmap for planetary protection to prepare for the first human missions to Mars	4
Harnessing nucleic acid technologies for human health on earth and in space	4
How do we transport plant species with desiccation-sensitive germplasm in space?	4
High throughput screen of small molecules as potential countermeasures to galactic cosmic radiation induced cellular dysfunction	4
Combined irradiation by gamma-rays and carbon-12 nuclei caused hyperlocomotion and change in striatal metabolism of rats	4
The COSPAR planetary protection policy for missions to Icy Worlds: A review of history, current scientific knowledge, and future directions	4
Food technologies for space missions	4
Increase in steryl glycoside levels and stimulation of lipid raft formation in azuki bean epicotyls under hypergravity conditions	4
HERA: A Timepix-based radiation detection system for Exploration-class space missions	4
Molecular and biomechanical changes of the cornea and lens in spaceflight	4
Radiation cataract in Heterogeneous Stock mice after γ-ray or HZE ion exposure	3
Cultivation and nutritional characteristics of Chlorella vulgaris cultivated using Martian regolith and synthetic urine	3
Characteristics of blood plasma proteome changes associated with the hemorrhagic purpura of cosmonauts on the first day after long-term space missions	3
Nonhuman primate models in the study of spaceflight stressors: Past contributions and future directions	3
Effects of X-ray irradiation and housing conditions on mitochondria in Peromyscus maniculatus	3
Limb position sense and sensorimotor performance under conditions of weightlessness	3
The COSPAR planetary protection requirements for space missions to Venus	3
In Memoriam	3
Non-DNA radiosensitive targets that initiate persistent behavioral deficits in rats exposed to space radiation	3
Dynamic visual acuity as a biometric for astronaut performance and safety	3
Protective effect of Gastrodia elata blume ameliorates simulated weightlessness-induced cognitive impairment in mice	3
Galactic cosmic ray simulation at the NASA space radiation laboratory – Progress, challenges and recommendations on mixed-field effects	3
Corrigendum to “Characterization of virulence-related phenotypes of Candida parapsilosis and Rhodotorula mucilaginosa isolated from the International Space Station (ISS)” [Life Sciences in Space Resea	3
A new type of ground-based simulator of radiation field inside a spacecraft in deep space	3
Human thermoregulation in microgravity environments: Insights from a computational model	3
Considerations for carcinogenesis countermeasure development using mouse models	3
Tryptophan metabolites are altered when Caco-2 cells are exposed to simulated microgravity	3
Reduced set-shifting processing speed in male rats following low dose (10 cGy) proton exposure	3
Compact portable sources of high-LET radiation: Validation and potential application for galactic cosmic radiation countermeasure discovery	3
Goldfish regenerated scale culture at low temperatures improves osteoblast and osteoclast survival in scales without loss of the osteoblast and osteoclast response to changes in gravity	3
Dose measurements with the Pille-ISS thermoluminescent dosimeter system during extravehicular activities (2004-2022)	2
Hydroponics for plant cultivation in space – a white paper	2
Leaf yield and mineral content of mizuna in response to cut-and-come-again harvest, substrate particle size, and fertilizer formulation in a simulated spaceflight environment	2
Recent observational studies on carbon-chain species with current facilities and future prospects with ALMA & JWST	2
Baoyuan jieyu formula ameliorates depression-like behaviour in rats induced by simulated long-term spaceflight composite stress through regulating MAPK and BDNF pathways	2
Advanced food packaging systems for space exploration missions	2
Crew time in a space greenhouse using data from analog missions and Veggie	2
Amorphous calcium carbonate enhances osteogenic differentiation and myotube formation of human bone marrow derived mesenchymal stem cells and primary skeletal muscle cells under microgravity condition	2
Carbonate precipitation and nitrogen fixation in AMG (Artificial Martian Ground) by cyanobacteria	2
Palmer Station, Antarctica: A ground-based spaceflight analog suitable for validation of biomedical countermeasures for deep space missions	2
Corrigendum to ‘Review of research into bioregenerative life support system(s) which can support humans living in space’ [life sciences in space research 31 (2021) 113–120]	2
Design and establishment of a large-scale controlled ecological life-support system integrated experimental platform	2
Application of functional microbial agent in aerobic composting of wheat straw for waste recycling	2
The microwave electromagnetic background as measured onboard the International Space Station	2
Effects of preexposure to a subthreshold dose of helium particles on the changes in performance produced by exposure to helium particles	2
Applicability of composite materials for space radiation shielding of spacecraft	2
3D bioprinting meniscus tissue onboard the International Space Station	2
Astrochemistry: The study of chemical processes in space	2
The effect of Hydrogen-rich water on retinal degeneration in the outer nuclear layer of simulated weightlessness rats	2
10-min exposure to a 2.5% hypercapnic environment increases cerebral blood blow but does not impact executive function	2
Radiation in human space exploration: Detectors and measurements, today and tomorrow	2
Microglia: Rheostats of space radiation effects in the CNS microenvironment	2
Stability of ice-embedded glycine under space ionizing radiations: a RT-TD-DFT and DFT study	2
Effects of hypobaria, hyperoxia, and nitrogen form on the growth and nutritional quality of lettuce	2
Gastrodia elata blume ameliorates circadian rhythm disorder-induced mice memory impairment	2
Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects	2
Characterization of virulence-related phenotypes of Candida parapsilosis and Rhodotorula mucilaginosa isolated from the International Space Station (ISS)	2
Microgravity as a contributing factor to venous thromboembolism development: Risks and prevention strategies	2
Neurostimulation as a technology countermeasure for dry eye syndrome in astronauts	2