OOIR: Observatory of International Research

Papers

(The median citation count of Life Sciences in Space Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Biofilm dynamics in space and their potential for sustainable space exploration – A comprehensive review	37
Space radiation measured during first-ever commercial suborbital mission on Virgin Galactic SpaceShipTwo Unity on 29 June 2023	34
Microbial diversity formation and maintenance due to temporal niche differentiation caused by low-dose ionizing radiation in oligotrophic environments	30
IFC - Editorial Board	26
Remembering Dr Rafael Navarro-González (1959–2021)	26
Comments on “EcAMSat spaceflight measurements of the role of σs in antibiotic resistance of stationary phase Escherichia coli in microgravity”	23
Parabolic Flight as a Research Platform to Investigate Ophthalmic Changes in Microgravity	21
Organ dose equivalents of albedo protons and neutrons under exposure to large solar particle events during lunar human landing missions	21
IFC - Editorial Board	21
Extracellular vesicles-derived microRNAs expression as biomarkers for neurological radiation injury: Risk assessment for space exploration	20
Anthocyanin can improve the survival of rice seeds from solar light outside the international space station	20
What can space radiation protection learn from radiation oncology?	20
Simulated microgravity alters the expression of plasma SSAO and its enzymatic activity in healthy rats and increases the mortality in high-fat diet/streptozotocin-induced diabetes	19
Rotational and Vibrational Signatures of Astrophyscially relevant Gas-Phase Stereo-isomeric Species of Proteinogenic Amino acid Leucine	19
rTMS Ameliorates time-varying depression and social behaviors in stimulated space complex environment associated with VEGF signaling	19
Active radiation measurements over one solar cycle with two DOSTEL instruments in the Columbus laboratory of the International Space Station	16
Long term food stability for extended space missions: a review	16
Microgravity alters the expressions of DNA repair genes and their regulatory miRNAs in space-flown Caenorhabditis elegans	16
Reduced gravity effects on gait coordinative structures	15
Susceptibility of extremophiles to far-UVC light for bioburden reduction in spacecraft assembly facilities	15
Leaf yield and mineral content of mizuna in response to cut-and-come-again harvest, substrate particle size, and fertilizer formulation in a simulated spaceflight environment	14
A polymerase chain reaction experiment using Escherichia coli and Mars sand simulant for detection and analysis of extraterrestrial life	14
Accelerating space radiation countermeasure development through drug repurposing	14
Solid waste management and resource recovery during the 4-crew 180-day CELSS integrated experiment	14
Effect of countermeasure bodygear on cardiac-vascular-respiratory coupling during 6-degree head-down tilt: An earth-based microgravity study	13

Different spectrum of space radiation induced cognitive impairments in radiation-naïve and adapted rats	13
Hydroponics for plant cultivation in space – a white paper	12
Effects of simulated microgravity and vibration on osteoblast and osteoclast activity in cultured zebrafish scales	11
Coordinated lunar time (LTC): Implications of a lunar-centric time zone on astronaut health and space medicine	10
IFC - Editorial Board	10
Spaceflight validation of technology for point-of-care monitoring of peripheral blood WBC and differential in astronauts during space missions	10
A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection	9
Medial prefrontal cortex and hippocampus in mice differently affected by simulate microgravity and social isolation associated with the alternation of emotional and cognitive functions	9
Design and establishment of a large-scale controlled ecological life-support system integrated experimental platform	9
Weighing the impact of microgravity on vestibular and visual functions	9
Advances in planetary sustainability	9
Challenges and innovations in food and water availability for a sustainable Mars colonization	9
Mechano-immunology in microgravity	9
Development of a NASA roadmap for planetary protection to prepare for the first human missions to Mars	9
Spaceflight associated dry eye syndrome (SADES): Radiation, stressors, and ocular surface health	8
Secondary proton buildup in space radiation shielding	8
Cardiovascular adaptations in microgravity conditions	8
Evolving radiological protection guidelines for exploration-class missions	8
IFC - Editorial Board	7
IFC - Editorial Board	7
Radiation in human space exploration: Detectors and measurements, today and tomorrow	7
Whole-transcriptome RNA sequencing reveals CeRNA regulatory network under long-term space composite stress in Rats	7
Comparison of the particle flux measured by Liulin-MO dosimeter in ExoMars TGO science orbit with those calculated by models	7
Report of the 6th (Virtual) Meeting on the Planetary Protection Knowledge Gaps for Human Missions to Mars on June 1–2, 2022	7
Lignocellulose degradation, biogas production and characteristics of the microbial community in solid-state anaerobic digestion of wheat straw waste	7
Reorganization of the mouse oocyte' cytoskeleton after cultivation under simulated weightlessness	7
Results from the Radiation Assessment Detector on the International Space Station: Part 1, the Charged Particle Detector	7
Armed Forces Radiobiology Research Institute/Uniformed Services University of the Health Sciences perspective on space radiation countermeasure discovery	7
A no-fault risk compensation approach for radiation risks incurred in space travel	7
Changes of iron dynamics in the duodenum and bone marrow under partial gravity condition in mice	7
Harnessing nucleic acid technologies for human health on earth and in space	6
Improving astronaut cancer risk assessment from space radiation with an ensemble model framework	6
Private Spaceflight: A New Landscape for Dealing with Medical Risk	6
The MaMBA facility as a testbed for bioregenerative life support systems	6
Combined effects of heavy ion exposure and simulated Lunar gravity on skeletal muscle	6
Observations of neutron radiation environment during Odyssey cruise to Mars	6
Mimic microgravity effect on muscle transcriptome under ionizing radiation	6
Residual radiation risk disparities across sex and race or ethnic groups for lifetime never-smokers on lunar missions	6
Mechanical interaction of myosin and native thin filament in the disused rat soleus muscle	5
Glycogen metabolism is required for optimal cyanobacterial growth in the rapid light-dark cycle of low-Earth orbit	5
Inhibition of SIRT1 by miR-138-5p provides a mechanism for inhibiting osteoblast proliferation and promoting apoptosis under simulated microgravity	5
HERA: A Timepix-based radiation detection system for Exploration-class space missions	5
Galactic cosmic ray environment predictions for the NASA BioSentinel mission	5
Imaging in spaceflight associated neuro-ocular syndrome (SANS): Current technology and future directions in modalities	5
Microglia: Rheostats of space radiation effects in the CNS microenvironment	5
RadLab: An open science resource for radiation studies relevant to human spaceflight	5
“Spaceflight-to-Eye Clinic”: Terrestrial advances in ophthalmic healthcare delivery from space-based innovations	5
Comprehensive analyses of plant hormones in etiolated pea and maize seedlings grown under microgravity conditions in space: Relevance to the International Space Station experiment “Auxin Transport”	5
Increase in steryl glycoside levels and stimulation of lipid raft formation in azuki bean epicotyls under hypergravity conditions	5
10-min exposure to a 2.5% hypercapnic environment increases cerebral blood blow but does not impact executive function	5

Moxifloxacin plus Cordyceps polysaccharide ameliorate intestinal barrier damage due to abdominal infection via anti-inflammation and immune regulation under simulated microgravity	5
Integrated analysis of miRNAome and transcriptome reveals that microgravity induces the alterations of critical functional gene modules via the regulation of miRNAs in short-term space-flown C. elegan	5
Extensive study of radiation dose on human body at aviation altitude through Monte Carlo simulation	5
Immersive gamma music as a tool for enhancing glymphatic clearance in astronauts while improving their mental well-being	4
Operation overview of a biological waste treatment system during the 4-crew 180-day integrated experiment in the controlled ecological life support system (CELSS)	4
Suppression of essential oil biosynthesis in sweet basil cotyledons under hypergravity conditions	4
Response to Comments on “EcAMSat spaceflight measurements of the role of σs in antibiotic resistance of stationary phase Escherichia coli in microgravity”	4
Investigating alterations in the cellular envelope of Staphylococcus aureus in simulated microgravity using a random positioning machine	4
Radiation cataract in Heterogeneous Stock mice after γ-ray or HZE ion exposure	4
The neutron dose equivalent rate measurements by R3DR/R2 sp ectrometers on the international space station	4
IFC - Editorial Board	4
Automatic measurements with the Pille-ISS thermoluminescent dosimeter system on board the International Space Station (2003–2021)	4
Activation of the visual system by space radiation: a novel study on Ca2+ signalling in ex-vivo rabbit eyes exposed to visible light, X-rays and high-energy protons	4
A new type of ground-based simulator of radiation field inside a spacecraft in deep space	4
Simulated weightlessness induces cognitive changes in rats illustrated by performance in operant conditioning tasks	4
Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model	4
Observation of the radiation environment and solar energetic particle events in Mars orbit in May 2018- June 2022	4
Corrigendum to ‘Review of research into bioregenerative life support system(s) which can support humans living in space’ [life sciences in space research 31 (2021) 113–120]	4
Dose measurements with the Pille-ISS thermoluminescent dosimeter system during extravehicular activities (2004-2022)	4
Lower body negative pressure as a research tool and countermeasure for the physiological effects of spaceflight: A comprehensive review	4
Nonhuman primate models in the study of spaceflight stressors: Past contributions and future directions	4
Cultivation and nutritional characteristics of Chlorella vulgaris cultivated using Martian regolith and synthetic urine	4
Comparative study of methods for detecting extraterrestrial life in exploration mission of Mars and the solar system	4
Considerations for carcinogenesis countermeasure development using mouse models	3
X-ray-downregulated nucleophosmin induces abnormal polarization by anchoring to G-actin	3
Extended reality quantification of pupil reactivity as a non-invasive assessment for the pathogenesis of spaceflight associated neuro-ocular syndrome: A technology validation study for astronaut healt	3
Construction of microgravity biological knowledge graph and its applications in anti-osteoporosis drug prediction	3
In Memoriam	3
Protective effect of Gastrodia elata blume ameliorates simulated weightlessness-induced cognitive impairment in mice	3
Effects of Neutron Radiation on Pharmaceuticals in Deep Space-like Environments - General Anesthesia in Space	3
Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel	3
Cardiovascular changes under the microgravity environment and the gut microbiome	3
Characteristics of blood plasma proteome changes associated with the hemorrhagic purpura of cosmonauts on the first day after long-term space missions	3
Galactic cosmic ray environment predictions for the NASA BioSentinel Mission, part 2:Post-mission validation	3
Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice	3
Corrigendum to ‘RadLab: An open science resource for radiation studies relevant to human spaceflight’ Life Sciences in Space Research Volume 43, November 2024, Pages 29-34	3
Survival of desert algae Chlorella exposed to Mars-like near space environment	3
Biomechanics of healthy subjects during exercise on a simulated vibration isolation and stabilization system	3
Reduced ossification caused by 3D simulated microgravity exposure is short-term in larval zebrafish	3
Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environments	3
Dynamic visual acuity as a biometric for astronaut performance and safety	3
A novel device to study altered gravity and light interactions in seedling tropisms	3
Optimizing autonomous artificial intelligence diagnostics for neuro-ocular health in space missions	3
Monte Carlo simulation of semiconductor-based detector in mixed radiation field in the atmosphere	3
Human thermoregulation in microgravity environments: Insights from a computational model	2
Effects of dietary aspirin on high-LET radiation-induced prostaglandin E2 levels and gastrointestinal tumorigenesis in Apc mice	2
Disparity in the effect of partial gravity simulated using a new apparatus on different rat hindlimb muscles	2
Bioregenerative dietary supplementation in space: Brassica rapa var. nipposinica and other Brassica cultivars	2
Comparison between PHITS and GEANT4 Simulations of the Heavy Ion Beams at the BEVALAC at LBNL and the Booster Accelerator at BNL	2
Infrared spectroscopy reveals ethylene glycol is an anti-crystallizer in water mixed astrochemical ices	2
Recent developments in space food for exploration missions: A review	2
Relationship of collagen as the component of the extracellular matrix with the mechanisms of autonomic regulation of the cardiovascular system under simulated conditions of long-term isolation	2
Comparison of two controlled-release fertilizer formulations for cut-and-come-again harvest yield and mineral content of Lactuca sativa L. cv. Outredgeous grown under International Space Station envir	2
The neurology of space flight; How does space flight effect the human nervous system?	2
Space biological and human survival: Investigations into plants, animals, microorganisms and their components and bioregenerative life support systems	2
Impedance threshold device as a countermeasure for spaceflight associated neuro-ocular syndrome (SANS): Mitigating mechanisms in proposed pathophysiology	2
Corrigendum to ’Hemerocallis citrina Baroni ameliorates chronic sleep deprivation-induced cognitive deficits and depressive-like behaviours in mice’ [Life Sciences in Space Research, Volume 40, Februa	2
Application of a Bayesian Statistical Framework for Planetary Protection as a Means of Verifying Low-Biomass, Zero-Inflated Test Data from Spacecraft	2
UV photo-degradation of the secondary lichen substance parietin: A multi-spectroscopic analysis in astrobiology perspective	2
Skeletal muscle deconditioning during partial weight-bearing in rodents – A systematic review and meta-analysis	2
Assessment of Spaceflight Medical Conditions’ and Treatments’ Potential Impacts on Behavioral Health and Performance	2
Real versus simulated galactic cosmic radiation for investigating cancer risk in the hematopoietic system - are we comparing apples to apples?	2
Effects of stepwise changes in dissolved carbon dioxide concentrations on metabolic activity in Chlorella for spaceflight applications	2
Optimized crop growth area composition for long duration spaceflight	2
Limb position sense and sensorimotor performance under conditions of weightlessness	2