Journal of Traditional and Complementary Medicine

Article	Citations
Keratinocyte Piezo1 and CD39 initiated the acupuncture analgesic signals via Co-regulating extracellular ATP mobilization at acupoints	77
NRICM101 in combatting COVID-19 induced brain fog: Neuroprotective effects and neurovascular integrity preservation in hACE2 mice	67
Corrigendum to “Integrated skin metabolomics and network pharmacology to explore the mechanisms of Goupi Plaster for treating knee osteoarthritis” [J Tradit, Complementary Altern Med 14 (6) (2024) 675	64
Corrigendum to “Inhibitory role of a smart nano-trifattyglyceride of Moringa oleifera root in epithelial ovarian cancer, through attenuation of FSHR - c-Myc axis” [J Tradit Complement Med 11(2021) 481	33
Qingfei Jiedu Granules fight influenza by regulating inflammation, immunity, metabolism, and gut microbiota	32
Polydatin: A natural compound with multifaceted anticancer properties	32
Jintiange capsule ameliorates glucocorticoid-induced osteonecrosis of the femoral head in rats by regulating the activity and differentiation of BMSCs	30
Cinnamic aldehyde, an anti-inflammatory component in Du-Huo-Ji-Sheng-Tang, ameliorates arthritis in II collagenase and monosodium iodoacetate induced osteoarthritis rat models	26
FM1 - Title Page	24
FM1 - Title Page	24
Therapeutic efficacy of Punarnavadi mandura against phenylhydrazine-induced hemolytic anemia in rats	24
FM1 - Title Page	23
Nootropic effect of Indian Royal Jelly against okadaic acid induced rat model of Alzheimer's disease: Inhibition of neuroinflammation and acetylcholineesterase	23
A review of recent artificial intelligence for traditional medicine	22
Acacia nilotica stem bark extract ameliorates obesity, hyperlipidemia, and insulin resistance in a rat model of high fat diet-induced obesity	22
Hypericum sampsonii exhibits anti-inflammatory activity in a lipopolysaccharide-induced sepsis mouse model	21
Effects of stimulating single acupoint and combination acupoints on diabetic gastroparesis: A randomised controlled trial study	21
Anti-inflammatory and antinociceptive effects of Aloysia gratissima leaves essential oil: An in vivo study	19
Anxiolytic-like and antidepressant-like effects of ethanol extract of Terminalia chebula in mice	19
Editorial note: Gut microbiota and health	19
Electroacupuncture enhances the effects of escitalopram oxalate on glucocorticoid-inducible genes, inflammation and neurotrophin in depressed patients	19
Yinxieling attenuates psoriasis in mice by regulating oxidative stress and lipid mediators to correct immune cell disorder through the NF-κB/Nrf2 signaling pathways	19
Integrated serum pharmacochemistry and network pharmacology to reveal the kernel material basis and underlying mechanisms of the fuzi-lizhong pill for ulcerative colitis	19
Hydroalcoholic extract of Passiflora incarnata improves the autistic-like behavior and neuronal damage in a valproic acid-induced rat model of autism	18
Phytochemical-rich vegetable and fruit juice alleviates oral mucositis during concurrent chemoradiotherapy in patients with locally advanced head and neck cancer	18

A diet enriched with Pistacia atlantica fruits improves the female rats' reproductive system	18
Kaixuan Qibi granules attenuate myocardial fibrosis through BRD4 blockade regulated by the NF-κB/NLRP3 signaling pathway	17
Role of herbal medicines in the management of patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials	17
Scalp and auricular acupuncture attenuate recurrent gastroesophageal reflux disease and related inflammatory cytokines	17
Bazi Bushen mitigates age-related muscular atrophy by alleviating cellular senescence of skeletal muscle	17
Genotoxicity and 28-day repeated dose oral toxicity study of garlic essential oil in mice	17
Potential probiotics for regulation of the gut-lung axis to prevent or alleviate influenza in vulnerable populations	16
Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways	16
Formulation and evaluation of SGLT2 inhibitory effect of a polyherbal mixture inspired from Ayurvedic system of medicine	16
Gan-Mai-Da-Zao-Tang attenuates age-induced skeletal muscle wasting and improves mitochondrial function in mice	16
Natural products as a source of novel drugs for treating SARS-CoV2 infection	15
Electroacupuncture improves cardiac function in hyperlipidemic rats by enhancing efferocytosis in myocardial macrophages via the PPARγ-LXRα-MerTK pathway	15
Integration proteomics analysis to identify AMPK as key target pathways of TCM formula for high fat diet induced obesity in mice	15
Electroacupuncture of ST36 and PC6 for postoperative gastrointestinal recovery: A systematic review and meta-analysis	15
Early intervention with Kan Jang® to treat upper-respiratory tract infections: A randomized, quadruple-blind study	14
Wound healing activity of the hydroethanolic extract of the leaves of Maytenus ilicifolia Mart. Ex Reis	14
Qingre huazhuo tang regulates IgA nephropathy through immune checkpoints and ferroptosis	14
Antiosteoporotic activity of nodakenetin, a coumarin compound from Angelica decursiva, by activation of the Wnt/β-catenin signaling pathway	14
HerBChain, a blockchain-based informative platform for quality assurance and quality control of herbal products	13
Investigate the mechanisms of novel verticinone derivatives on lung cancer cell line (A549) by network pharmacology and transcriptome	13
Zhongfeng Xingnao prescription alleviates injury of intracerebral hemorrhage via regulating the CaMKII/NF-κB p65/NLRP3/GSDMD signaling axis	13
Inhibitory effect of honokiol on furin-like activity and SARS-CoV-2 infection	13
Investigating the potential of the Chinese herbal remedy SS-1 for the treatment of Sjögren's syndrome via the interleukin-17 signaling axis	12
The influence of the gut-brain axis on anxiety and depression: A review of the literature on the use of probiotics	12
Unveiling pharmacological targets of Rihimaside C for radiation-induced lung injury: An in silico and experimental integrated approach	12
Cordyceps militaris and Armillaria mellea formula alleviates depressive behaviors via microglia regulation in an unpredictable chronic mild stress animal model	12
Hydrocotyle bonariensis Comm ex Lamm (Araliaceae) leaves extract inhibits IKs not IKr potassium currents: Potential implications for anti-arrhythmic therapy	11
Protective effects of Thai Mucuna pruriens (L.) DC. var. pruriens seeds on sexual behaviors and essential reproductive markers in chronic unpredictable mild stress mice	11
WITHDRAWN: Curcuma longa alone and in combination with pioglitazone attenuates paraquat-induced lung injury in rats through improving inflammation, oxidative stress and fibrosis	11
Spatholobus suberectus Dunn inhibits breast cancer bone metastasis in vitro and in vivo	11
Corrigendum to “Wound healing potential of Acacia catechu in streptozotocin-induced diabetic mice using in vivo and in silico approach” [J Tradit Compl Med 13 (5) (2023) 489–499]	11
FM2- Aims & Scope	11
Enhanced bone tissue regeneration via mesenchymal stem cells-laden Alginate/GelMa 3D-Bioprinted scaffold treated with Haplophyllum tuberculatum extract	11
Boswellic acid formulations are not suitable for treatment of pediatric high-grade glioma due to tumor promoting potential	11
Eriodictyol attenuates doxorubicin-induced nephropathy by activating the AMPK/Nrf2 signalling pathway	10
Hovenia dulcis Thunb. monofloral honey attenuates LPS-induced inflammation and endotoxemia through the activation of the Nrf2/HO-1 axis	10
Baicalin inhibits the replication of the hepatitis B virus by targeting TRIM25	10
A comprehensive study on the underlying mechanisms of the lipid-lowering effects of Bao Li Er Capsule in hyperlipidemia	10
The effects of P. atlantica as a libido booster and sexual enhancer on the reproductive system of male rats	10
Sansoninto attenuates aggressive behavior and increases levels of homovanillic acid, a dopamine metabolite, in social isolation-reared mice	10
Traditional Chinese medicine as a protective strategy against chemotherapy-induced cardiotoxicity: An overview of the literature	10
When sng meets acupuncture -- a paradigm-shift biomarker for translational research	10
Sophorae tonkinensis radix polysaccharide attenuates acetaminophen-induced liver injury by regulating the miR-140-5p-related antioxidant mechanism	10
Efficacy of Jawarish Shahi a herbal formulation in irritable bowel syndrome: An open-labeled single-arm clinical trial	10
Front Matter 1 - Full Title Page	10
Cognitive changes mediated by adenosine receptor blockade in a resveratrol-treated atherosclerosis-prone lupus mouse model	10
Acupuncture is associated with reduced dementia risk in patients with insomnia: A propensity-score-matched cohort study of real-world data	9
Study on the mechanism of action of effective monomeric, berberine of Xianglian Pill in inhibiting human colon cancer cells based on fatty acid synthase target	9
Vitisin B, a resveratrol tetramer from Vitis thunbergii var. taiwaniana, ameliorates impaired glucose regulations in nicotinamide/streptozotocin-induced type 2 diabetic mice	9
Analyzing mechanisms of qing fei bao yuan decoction granules in treating COPD based on LC-MS, network pharmacology and in vivo methods	9

Acute toxicity profiling of medicinal herb Ardisia elliptica leaf extract by conventional evaluations and proton nuclear magnetic resonance (NMR) metabolomics	9
In Memory of Professor Kuo-Hsiung Lee (K. H. Lee)	9
Protective effects of tiger milk mushroom extract (xLr®) against UVB irradiation in Caenorhabditis elegans via DAF-16 anti-oxidant regulation	9
Therapeutic efficacy of a Dioscorea membranacea extract in a rat model of hepatocellular carcinoma: Histopathological aspects	9
A formulation of combined Poria cocos and Cordyceps militaris rice ameliorates depressive-like effects by downregulating p38 MAPK signaling pathways	9
Computational studies on searching potential phytochemicals against DNA polymerase activity of the monkeypox virus	9
Polysaccharides derived from alkali-extracted vinegar-baked Radix Bupleuri suppress hyperimmune T lymphocytes and ameliorate skin graft rejection	9
Anti-inflammatory and polarization-modulating effects of Houttuynia cordata in LPS-stimulated RAW264.7 macrophages	8
Study on the pharmacodynamics and related mechanism of Tangningtongluo tablet on prediabetes mice based on the theory of “liver controlling dispersion”	8
Effect of electrode configuration in electroacupuncture on ischemic stroke treatment in rats	8
Tianqi pingchan granule promotes recovery of glymphatic system function in a rat model of l-DOPA-induced dyskinesia	8
Withdrawal notice to: “Knowledge and attitudes towards utilizing complementary and alternative medical (CAM) treatments by mental health practitioner from various disciplines” [J Tradit Complement Med	8
Rapid changes of miRNAs-20, -30, −410, −515, −134, and −183 and telomerase with psychological activity: A one year study on the relaxation response and epistemological considerations	7
The characterization of traditional Chinese medicine natures and flavors using network pharmacology integrated strategy	7
Modulation of psoriatic-like skin inflammation by traditional Indian medicine Divya-Kayakalp-Vati and Oil through attenuation of pro-inflammatory cytokines	7
An assessment of the growth inhibition profiles of Hamamelis virginiana L. extracts against Streptococcus and Staphylococcus spp.	7
Holothuria scabra extracts confer neuroprotective effect in C. elegans model of Alzheimer's disease by attenuating amyloid-β aggregation and toxicity	7
Optimization of the formulation of Tubiechong gel plaster and its effect on fracture healing by promoting angiogenesis in a rat model	7
Computational and biological insights for anti-cancer effects of Karanjin through AR/ER modulation, ROS generation and cell cycle arrest in prostate cancer	7
FM1 - Title Page	7
Network pharmacology-based study to investigate the mechanism of compound houttuynia mixture against influenza virus infection by suppressing TLR7/MyD88 signaling pathway	7
Antinociceptive efficacy of Clerodendrum petasites S. Moore, a Thai medicinal plant, and its CNS safety profiles	7
Curcumin alone not combined with piperine exerts cardioprotective effects in pressure-overload rats by increasing glucagon-like peptide-1 receptor signaling and additional properties	6
Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging	6
Curcumol promotes ferroptosis of colon cancer by targeting the ubiquitination and degradation of GPX4	6
FM1 - Title Page	6
Clinical effects of acupuncture treatment for prevention of insomnia-induced stroke: A large-scale cohort study	6
Antidiarheal activity of catechol and ethyl 5, 8,11,14,17 – icosapentanoate-rich fraction of Annona senegalensis stem bark	6
Role of IGF1/IGFR signaling pathway in neuroprotective effect of Shengmai Dihuang Decoction on CIH-induced cognitive impairment	6
Astragalus mongholicus polysaccharides alleviate insulin resistance through modulation of PI3K/AKT, TLR4/NF-kB signaling pathway and microbiota in rats with Type 2 Diabetes Mellitus	6
Elucidating the mechanism of traditional Chinese medicine formula (Yifei-sanjie Pill) in alleviating the chemobrain based on network pharmacology and experimental verification	5
Prevention of post-surgical adhesion bands by local administration of frankincense n-hexane extract	5
Chinese herbal medicine alleviates renal impairment induced by immunosuppressants in patients post living donor liver transplantation	5
Integrating pharmacokinetics and network pharmacology to decipher the efficacy of Fufang Qinlan oral liquid on post infectious cough	5
Plant polysaccharides utilized by gut microbiota: New players in ameliorating cognitive impairment	5
FM2- Aims & Scope	5
Conventional disease-modifying anti-rheumatic drugs combined with Chinese Herbal Medicines for rheumatoid arthritis: A systematic review and meta-analysis	5
Cell-free Lactiplantibacillus plantarum OC01 supernatant suppresses IL-6-induced proliferation and invasion of human colorectal cancer cells: Effect on β-Catenin degradation and induction of autophagy	5
DHA-rich fish oil and Tualang honey reduce chronic stress-induced oxidative damage in the brain of rat model	5
Spatholobus suberectus inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling pathway	5
A novel postbiotic from Lacticaseibacillus rhamnosus CRL1505 able to enhance the steady-state myelopoiesis	5
In silico anti-viral assessment of phytoconstituents in a traditional (Siddha Medicine) polyherbal formulation – Targeting Mpro and pan-coronavirus post-fusion Spike protein	5
Electroacupuncture promotes the repair of lacrimal glands damage in dry-eye animal models by modulating the BDNF/CREB signaling pathway	5
Combination therapy of shinbaro and celecoxib improves joint pain and cartilage degradation in an osteoarthritis mouse model	5
Solid herbal extract of Primula veris L. improves morphofunctional condition of rats’ myocardium in chronic alcohol intoxication	5
Psycho-physio-biochemical modulations brought by Integrated Amrita Meditation (IAM®) relieved stress and improved glycemic control in type 2 diabetic subjects	5
Role of gut microbiota metabolism and biotransformation on dietary natural products to human health implications with special reference to biochemoinformatics approach	5
In-silico evaluation of bioactive compounds from tea as potential SARS-CoV-2 nonstructural protein 16 inhibitors	5
Evaluating the antiviral efficacy and specificity of chlorogenic acid and related herbal extracts against SARS-CoV-2 variants via spike protein binding intervention	5
Gastroprotective effects of Machilus zuihoensis Hayata bark against acidic ethanol-induced gastric ulcer in mice	5
In vitro effects and mechanisms of action of Bidens pilosa in Trypanosoma brucei	5
Himatanthus bracteatus stem bark ethanolic extract obtained by sequential pressurized liquid extraction: Chromatographic characterization and profiling of cytotoxic, antitumoral and immunopharmacologi	4
The chemical composition of Diwu YangGan capsule and its potential inhibitory roles on hepatocellular carcinoma by microarray-based transcriptomics	4
Effects of acupuncture at ST-36 (Zusanli) on pain and associated sleep disturbance	4
Effect of astragalus membranaceus on neurological function in acute aneurysmal subarachnoid hemorrhage patients with high inflammation: A preliminary randomized, double-blind, placebo-controlled clini	4
Geniposide activates the transcription of Ndufs8 and enhances PD-L1 blockade for inhibiting growth of osteosarcoma	4
Osthole attenuates trastuzumab-induced cardiotoxicity in mice by enhancing autophagy via regulating the p38MAPK/mTOR signaling pathway	4
Zhilong Huoxue Tongyu capsule alleviates myocardial fibrosis by improving endothelial cell dysfunction	4
Mitigation of hypobaric hypoxia induced renal inflammatory alterations by quercetin prophylaxis	4
Explore the action mechanism of Danggui Buxue decoction on chronic heart failure in rats by proteomics and untargeted metabolomics	4
Peperomia pellucida extracts stimulates bone healing in alveolar socket following tooth extraction	4
Efficacy of Triphala extracts on the changes of obese fecal microbiome and metabolome in the human gut model	4
FM1 - Title Page	4
ZishenWan reduces obesity in db/db mice by inhibiting p21 expression in adipose tissues	4
Detam 1 black soybean against cisplatin-induced acute ren failure on rat model via antioxidant, antiinflammatory and antiapoptosis potential	3
Zhoushi Qi Ling decoction inhibits the progression of castration-resistant prostate cancer in vivo by regulating macrophage infiltration via IL6-STAT3 signaling	3
Antispasmodic, cardioprotective and blood-pressure lowering properties of Gomphrena perennis L. and its mechanisms of action	3
Red rice bran aqueous extract ameliorate diabetic status by inhibiting intestinal glucose transport in high fat diet/STZ-induced diabetic rats	3
FM2- Aims & Scope	3
FM2- Aims & Scope	3
Guilingji capsules enhances erectile function by promoting testosterone-dependent angiogenesis in the corpus cavernosum	3
Corrigendum to “Chinese herbal medicine may reduce major adverse cardiovascular events in patients with dialysis hypotension: A Taiwan nationwide cohort study” [J Tradit Complementary Med 14, Issue 5	3
Unlocking the mechanistic potential of Thuja occidentalis for managing diabetic neuropathy and nephropathy	3
Nao-Xin-Qing tablet inhibits macrophage inflammatory response in atherosclerosis via AMPK-α/SIRT1/PPAR-γ pathway	3
Lepidium meyenii (maca) and soy isoflavones reduce cardiac stunning of ischemia-reperfusion in rats by mitochondrial mechanisms	3
Achillea extracts elicit anti-diabetic neuropathic pain by modulating inflammatory cytokines	3
Cinnamaldehyde inhibits the NLRP3 inflammasome and inflammatory response by reducing oxidative stress in Neisseria gonorrhoeae-infected macrophages	3
Effect and mechanism of pearl on ovarian function of rats with premature ovarian failure induced by tripterygium glycosides	3
Comparison and effect of moxibustion and acupuncture on Nogo/NgR signaling pathway in rats with cerebral ischemia/reperfusion injury	3
Neuroprotective effects of Tradescantia spathacea tea bioactives in Parkinson’s disease: In vivo proof-of-concept	3

Pulsatilla saponin inhibits the proliferation of keratinocytes and ameliorates imiquimod-induced psoriasis through the NF-κB and STAT3 signaling pathways	3
Auricular acupuncture plays a neuroprotective role in 6-hydroxydopamine-induced Parkinson's disease in rats	3
Meridian energy analysis may predict the prognosis of patients with advanced cancers receiving palliative care	3
Calendulaglycoside A showing potential activity against SARS-CoV-2 main protease: Molecular docking, molecular dynamics, and SAR studies	3
Ex vivo and in vitro inhibitory potential of Kava extract on monoamine oxidase B activity in mice	3
Integrated lipidomics and network pharmacology analysis to determine how Gu Fu Sheng Capsule improves lipid metabolism in rats with steroid-induced osteonecrosis of the femoral head	3
Antihyperglycemic and anti-type 2 diabetic activity of marine hydroquinone isolated from brown algae (Dictyopteris polypodioides)	3
Mechanism of Atractylenolide Ⅲ alleviating pyrotinib-induced diarrhea by regulating AMPK/CFTR pathway through metabolite of gut microbiota	3
Taiyintiaowei-Tang ameliorates hepatic steatosis of mice fed with acute high-fat diet plus alcohol binge by blockade of NLRP3 inflammasome	3
In silico and in vitro studies of potential inhibitors against Dengue viral protein NS5 Methyl Transferase from Ginseng and Notoginseng	2
Plant-derived natural medicines for the management of osteoporosis: A comprehensive review of clinical trials	2
Protective role of vitamin D3 in a rat model of hyperthyroid-induced cardiomyopathy	2
Guan-Xin-Kang and its active compound astragaloside IV improve atherosclerosis through extracellular signal-regulated kinase 5-mediated macrophage efferocytosis	2
Integrating HPLC-Q-TOF-MS/MS, network pharmacology and experimental validation to decipher the chemical substances and mechanism of modified Gui-shao-liu-jun-zi decoction against gastric cancer	2
Electroacupuncture at GB34 modulates neurogenesis and BDNF-ERK signaling in a mouse model of Parkinson's disease	2
Antidepressant-like effect of Campomanesia xanthocarpa seeds in mice: Involvement of the monoaminergic system	2
Arenobufagin causes ferroptosis in human gastric cancer cells by increasing rev-erbα expression	2
Exploring the pivotal variables of tongue diagnosis between patients with acute ischemic stroke and health participants	2
FM2- Aims & Scope	2
Transcriptome and metabolome changes induced by bitter melon (Momordica charantia)- intake in a high-fat diet induced obesity model	2
Antcin-H, a natural triterpene derived from Antrodia cinnamomea, ameliorates dextran sulfate sodium-induced colitis in mice by inhibiting the NLRP3 inflammasome	2
Ethnomedicinal uses, Phytochemistry, and Biological Properties of Ammoides pusilla (Brot.) Breistr : a comprehensive review	2
Jieduquyuziyin prescription attenuates the side effect of prednisone through regulating gut microbiota when in the combination with prednisone treat MRL/lpr mice	2
Bushen Huoxue Recipe enhances the immune microenvironment at the maternal-fetal interface via the Hippo signaling pathway in mice with recurrent spontaneous abortion	2
Raddeanin A promotes the apoptosis of gastric cancer in conjunction with autophagy inhibitor Hydroxychloroquine via MAPK signaling pathway	2
Role of acupuncture in critically ill patients: A systematic review	2
A proteasome-dependent inhibition of SIRT-1 by the resveratrol analogue 4,4′-dihydroxy-trans-stilbene	2
Diabetes mellitus: Preventive and curative therapies with aqueous extract of Rytigynia senegalensis Blume (Rubiaceae) in Wistar rats	2
Exploring the ROS-mediated anti-cancer potential in human triple-negative breast cancer by garlic bulb extract: A source of therapeutically active compounds	2
Beneficial effect of mindfulness based stress reduction on optic disc perfusion in primary open angle glaucoma: A randomized controlled trial	2
Gut-joint axis: Oral Probiotic ameliorates Osteoarthritis	2
Mechanistic insights into the antimycobacterial action of unani formulation, Qurs Sartan Kafoori	2
Salvianic acid A promotes osteogenic differentiation of bone marrow mesenchymal stem cells in senile osteoporosis through bromodomain-containing protein 4/Ariadne RBR E3 ubiquitin-protein ligase 1/Rub	2
Alpinia katsumadai seed from a condiment to ethnomedicine to nutraceutical, a comprehensive review of its chemistry and health benefits	2
In vivo evaluation of Andrographis paniculata and Boesenbergia rotunda extract activity against SARS-CoV-2 Delta variant in Golden Syrian hamsters: Potential herbal alternative for COVID-19 treatment	2
Qingguang'an-induced autophagy in TFs inhibits scar formation: A follow-up in vivo mechanistic investigation	2
Molecular study of the KCNJ11 gene and its correlation with Prakriti to preventing and managing type 2 diabetes	2
FM2- Aims & Scope	2
FM1 - Title Page	2
Anti-rheumatoid activity of a hexane-insoluble fraction from Plantago major in female Wistar rats induced by Complete Freund's Adjuvant	2
Hepatic transcriptome discloses the potential targets of Xuefu Zhuyu Decoction ameliorating non-alcoholic fatty liver disease induced by high-fat diet	2
A novel phenolic formulation for treating hepatic and peripheral insulin resistance by regulating GLUT4-mediated glucose uptake	2
Virtual screening by targeting proteolytic sites of furin and TMPRSS2 to propose potential compounds obstructing the entry of SARS-CoV-2 virus into human host cells	2
Integration of transcriptomics and metabolomics to study the mechanism of Siwei Huangqi powder in Tibetan medicine for protecting against high-altitude hypoxic brain injuries	2
Coptis chinensis, and extracts of guava and mulberry leaves present good inhibiting potential on obesity and associated metabolic disorders in high-fat diet obesity mice model	2