OOIR: Observatory of International Research

Papers

(The H4-Index of Biomedicines is 73. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Effects of Platelet-Rich Fibrin on In Vitro Periodontal Ligament Cell Functions	415
The Influence of Anesthetics on the Functions of the Endothelium and Oxidative Stress: A Critical Review	275
Myogenetic Oligodeoxynucleotides as Anti-Nucleolin Aptamers Inhibit the Growth of Embryonal Rhabdomyosarcoma Cells	251
Extracellular Vesicles’ Genetic Cargo as Noninvasive Biomarkers in Cancer: A Pilot Study Using ExoGAG Technology	232
Chronic Sleep Deprivation Causes Anxiety, Depression and Impaired Gut Barrier in Female Mice—Correlation Analysis from Fecal Microbiome and Metabolome	206
GSDME in Endothelial Cells: Inducing Vascular Inflammation and Atherosclerosis via Mitochondrial Damage and STING Pathway Activation	201
Testosterone as a Biomarker of Adverse Clinical Outcomes in SARS-CoV-2 Pneumonia	196
Generalisation of EEG-Based Pain Biomarker Classification for Predicting Central Neuropathic Pain in Subacute Spinal Cord Injury	195
Relationship of Hematological Profiles with the Serum Complement System in Patients with Systemic Lupus Erythematosus	187
In Vivo Osteogenic and Angiogenic Properties of a 3D-Printed Isosorbide-Based Gyroid Scaffold Manufactured via Digital Light Processing	185
Progeria and Aging—Omics Based Comparative Analysis	174
Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches	168
The Potential Role of Myokines/Hepatokines in the Progression of Neuronal Damage in Streptozotocin and High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice	161
Recent Advances and Perspectives on the Use of Mineralocorticoid Receptor Antagonists for the Treatment of Hypertension and Chronic Kidney Disease: A Review	149
Mechanisms and Assessment of Genotoxicity of Metallic Engineered Nanomaterials in the Human Environment	146
Restoring the Balance between Pro-Inflammatory and Anti-Inflammatory Cytokines in the Treatment of Rheumatoid Arthritis: New Insights from Animal Models	143
Emerging Therapy for Diabetic Cardiomyopathy: From Molecular Mechanism to Clinical Practice	136
Effect of Semaglutide on Subclinical Atherosclerosis and Cardiometabolic Compensation: A Real-World Study in Patients with Type 2 Diabetes	135
Focused Modulation of Brain Activity: A Narrative Review	129
The New Phytocomplex AL0042 Extracted from Red Orange By-Products Inhibits the Minimal Hepatic Encephalopathy in Mice Induced by Thioacetamide	123
Chondrogenic Potential of Human Umbilical Cord Mesenchymal Stem Cells Cultured with Exosome-Depleted Fetal Bovine Serum in an Osteoarthritis Mouse Model	122
Search Strategy Analysis of 5xFAD Alzheimer Mice in the Morris Water Maze Reveals Sex- and Age-Specific Spatial Navigation Deficits	118
Lysine Acetylome of Breast Cancer-Derived Small Extracellular Vesicles Reveals Specific Acetylation Patterns for Metabolic Enzymes	118
Emerging Epigenetic Therapies for the Treatment of Cardiac Fibrosis	118
In Vitro Evaluation of the Most Active Probiotic Strains Able to Improve the Intestinal Barrier Functions and to Prevent Inflammatory Diseases of the Gastrointestinal System	116

Bone Mineral Density Is a Predictor of Mortality in Female Patients with Cholangiocellular Carcinoma Undergoing Palliative Treatment	114
Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis	112
Soluble Factors and Receptors Involved in Skin Innate Immunity—What Do We Know So Far?	111
Chronic Kidney Disease in Boys with Posterior Urethral Valves–Pathogenesis, Prognosis and Management	104
Fertility Preservation and Reproductive Potential in Transgender and Gender Fluid Population	104
A Review of the Recent Development in the Synthesis and Biological Evaluations of Pyrazole Derivatives	103
Glycosylation Alterations in Cancer Cells, Prognostic Value of Glycan Biomarkers and Their Potential as Novel Therapeutic Targets in Breast Cancer	103
Interplay between Artificial Intelligence and Biomechanics Modeling in the Cardiovascular Disease Prediction	103
Exploration of Gene Therapy for Alport Syndrome	102
The Role of Adipokines in Tumor Progression and Its Association with Obesity	101
The Antioxidative Effects of Flavones in Hypertensive Disease	96
Navigating Hemorrhagic Shock: Biomarkers, Therapies, and Challenges in Clinical Care	94
An NF-κB- and Therapy-Related Regulatory Network in Glioma: A Potential Mechanism of Action for Natural Antiglioma Agents	94
Aldose Reductase as a Key Target in the Prevention and Treatment of Diabetic Retinopathy: A Comprehensive Review	92
The Impact of Maternal Obesity on Adipose Progenitor Cells	91
Early Diagnostic Markers and Risk Stratification in Sepsis: Prognostic Value of Neutrophil-to-Lymphocyte Ratio, Platelets, and the Carmeli Score	91
Why Is Iron Deficiency/Anemia Linked to Alzheimer’s Disease and Its Comorbidities, and How Is It Prevented?	90
Intensive Periodontal Treatment Does Not Affect the Lipid Profile and Endothelial Function of Patients with Type 2 Diabetes: A Randomized Clinical Trial	90
Cerebral Edema in Traumatic Brain Injury	87
A Closer Look at the Perivascular Unit in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus	87
Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors	86
Characteristics and Outcomes in Primary Aldosteronism Patients Harboring Glucocorticoid-Remediable Aldosteronism	86
Mortality Risk and Urinary Proteome Changes in Acute COVID-19 Survivors in the Multinational CRIT-COV-U Study	85
Physical Health and Transition to Psychosis in People at Clinical High Risk	85
Low-Dose Estrogens as Neuroendocrine Modulators in Functional Hypothalamic Amenorrhea (FHA): The Putative Triggering of the Positive Feedback Mechanism(s)	83
Metabolic Syndrome, Kidney-Related Adiposity, and Kidney Microcirculation: Unraveling the Damage	82
Molecular Mechanisms of Thyroid Hormone Signaling in Thyroid Cancer: Oncogenesis, Progression, and Therapeutic Implications	82
Correction: Damiański et al. Pathway to Remission in Severe Asthma: Clinical Effectiveness and Key Predictors of Success with Benralizumab Therapy: A Real-Life Study. Biomedicines 2025, 13, 887	82
Oncolytic Adenovirus, a New Treatment Strategy for Prostate Cancer	82
Short-Term Cyclosporin A Treatment Reduced Serum Neurofilament-Light Levels in Diffuse but Not Focal Traumatic Brain Injury in a Piglet Model	80
Concerted Regulation of Glycosylation Factors Sustains Tissue Identity and Function	79
Double-Negative T (DNT) Cells in Patients with Systemic Lupus Erythematosus	77
Therapeutic Targets and Approaches to Manage Inflammation of NAFLD	77
Unveiling the Native Morphology of Extracellular Vesicles from Human Cerebrospinal Fluid by Atomic Force and Cryogenic Electron Microscopy	76
Natural Compounds of Salvia L. Genus and Molecular Mechanism of Their Biological Activity	76
Applying Wearable Sensors and Machine Learning to the Diagnostic Challenge of Distinguishing Parkinson’s Disease from Other Forms of Parkinsonism	76
Humoral Immune Response in IBD Patients Three and Six Months after Vaccination with the SARS-CoV-2 mRNA Vaccines mRNA-1273 and BNT162b2	76
PSMA Expression Correlates with Improved Overall Survival and VEGF Expression in Glioblastoma	75
Neutrophil Heterogeneity in Wound Healing	75
Preclinical Safety Profile of Deg-AZM, a Clinical-Stage New Transgelin Agonist: hERG Inhibition Study In Vitro, Cardiovascular–Respiratory Pharmacology, and Single/Repeated-Dose Toxicity in Beagle Dog	75
Suppressing Inflammation for the Treatment of Diabetic Retinopathy and Age-Related Macular Degeneration: Dazdotuftide as a Potential New Multitarget Therapeutic Candidate	74
Percutaneous Temporary Mechanical Circulatory Support as a Bridge to Heart Transplantation in the Current UNOS Allocation System	74
Immunosuppression in Sepsis: Biomarkers and Specialized Pro-Resolving Mediators	74
Minimal Clinically Important Differences in EQ-5D-5L Index and VAS after a Respiratory Muscle Training Program in Individuals Experiencing Long-Term Post-COVID-19 Symptoms	74
The Gut Microbiome–Brain Crosstalk in Neurodegenerative Diseases	74
Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches 2.0	74
Topical Application of No-Ozone Cold Plasma in Combination with Vitamin C Reduced Skin Redness and Pigmentation of UV-Irradiated Mice	73
Modeling of Blood Flow Dynamics in Rat Somatosensory Cortex	73