Frontiers in Cell and Developmental Biology

Article	Citations
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype	646
Iron Metabolism in Ferroptosis	420
PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance	317
Mitophagy, Mitochondrial Homeostasis, and Cell Fate	302
Oxidative Damage and Antioxidant Defense in Ferroptosis	260
Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies	216
Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors	207
Characteristics and Biomarkers of Ferroptosis	206
MicroRNAs: From Mechanism to Organism	198
Metabolism of Amino Acids in Cancer	179
The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models	154
The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues	149
In vitro Models of Neurodegenerative Diseases	147
Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies	145
Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role	139
The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy	136
Selective Targeting of TNF Receptors as a Novel Therapeutic Approach	128
On-Target Anti-TGF-β Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges?	127
Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects	125
The Pyroptosis-Related Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Gastric Cancer	123
The mTOR–Autophagy Axis and the Control of Metabolism	122
Premature Ovarian Insufficiency: Past, Present, and Future	116
Interplay Between Lipid Metabolism and Autophagy	114
N6-Methylandenosine-Related lncRNAs Are Potential Biomarkers for Predicting the Overall Survival of Lower-Grade Glioma Patients	114
Exosomes, a New Star for Targeted Delivery	111

Cathepsin K: The Action in and Beyond Bone	110
Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application	108
Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation	108
Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression	108
The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines	106
The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease	105
Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming	104
Laboratory Testing Methods for Novel Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)	104
The Mechanics of Mitotic Cell Rounding	102
Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Dysfunction	101
Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy	101
BMSC-Derived Exosomal miR-29a Promotes Angiogenesis and Osteogenesis	101
Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression	100
Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment – New Findings and Future Perspectives	100
Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy	100
The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration	98
Bearing My Heart: The Role of Extracellular Matrix on Cardiac Development, Homeostasis, and Injury Response	95
Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man	95
The Role of Autophagy in Osteoarthritis	94
Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis	93
GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases	91
Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity	90
The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia	90
Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease	90
Regulatory Mechanisms of Vitellogenesis in Insects	89
Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds	88
Biological Function of Long Non-coding RNA (LncRNA) Xist	88
Notch Signaling in Vascular Endothelial Cells, Angiogenesis, and Tumor Progression: An Update and Prospective	88
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging	88
Epigenetics of Male Infertility: The Role of DNA Methylation	88
The Extracellular Matrix in Skin Inflammation and Infection	88
Hepatic Stellate Cells and Hepatocarcinogenesis	87
Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2	87
Roles of Macrophages in the Development and Treatment of Gut Inflammation	87
Cancer-Associated Fibroblast (CAF) Heterogeneity and Targeting Therapy of CAFs in Pancreatic Cancer	86
New Insights of Emerging SARS-CoV-2: Epidemiology, Etiology, Clinical Features, Clinical Treatment, and Prevention	84
The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders	84
Mitochondrial Dynamics: Fission and Fusion in Fate Determination of Mesenchymal Stem Cells	83
Recent Trends in the Development of Bone Regenerative Biomaterials	83
Horizontal Gene Transfer: From Evolutionary Flexibility to Disease Progression	83
Deciphering Epitranscriptome: Modification of mRNA Bases Provides a New Perspective for Post-transcriptional Regulation of Gene Expression	83
Mitochondrial Transfer and Regulators of Mesenchymal Stromal Cell Function and Therapeutic Efficacy	82
Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges	81
Development and Validation of a Combined Ferroptosis and Immune Prognostic Classifier for Hepatocellular Carcinoma	81
Targeting Mitochondrial Impairment in Parkinson's Disease: Challenges and Opportunities	80
The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies	80
Named Entity Recognition and Relation Detection for Biomedical Information Extraction	80
Signaling Pathways Involved in Diabetic Renal Fibrosis	80
Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease	79
Mitochondria-Associated ER Membranes – The Origin Site of Autophagy	79

Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities	79
Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System	79
Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming	79
Severity Detection for the Coronavirus Disease 2019 (COVID-19) Patients Using a Machine Learning Model Based on the Blood and Urine Tests	79
The Why of YY1: Mechanisms of Transcriptional Regulation by Yin Yang 1	78
The “Neuro-Glial-Vascular” Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction	78
The Role of Mitochondrial Dynamics and Mitophagy in Carcinogenesis, Metastasis and Therapy	78
Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery	78
CXCL11 Correlates With Antitumor Immunity and an Improved Prognosis in Colon Cancer	77
Macrophage Dysregulation and Impaired Skin Wound Healing in Diabetes	77
The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy	77
Immunomodulatory Properties of Mesenchymal Stromal Cells: An Update	76
Adipogenesis, Osteogenesis, and Chondrogenesis of Human Mesenchymal Stem/Stromal Cells: A Comparative Transcriptome Approach	75
The Therapeutic Potential of Mesenchymal Stromal Cells for Regenerative Medicine: Current Knowledge and Future Understandings	74
Characterization of Human Colon Organoids From Inflammatory Bowel Disease Patients	74
Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells	74
Tissue-Resident Macrophage Development and Function	73
Glucose Metabolism and Glucose Transporters in Breast Cancer	73
The Integral Role of RNA in Stress Granule Formation and Function	73
Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways	72
ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication	72
Evaluating DNA Methylation, Gene Expression, Somatic Mutation, and Their Combinations in Inferring Tumor Tissue-of-Origin	72
Therapeutic Use of Mesenchymal Stromal Cells: The Need for Inclusive Characterization Guidelines to Accommodate All Tissue Sources and Species	72
Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case Report	72
Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment	71
The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice	70
The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment	70
Blockade of GCH1/BH4 Axis Activates Ferritinophagy to Mitigate the Resistance of Colorectal Cancer to Erastin-Induced Ferroptosis	70
Exosomal miRNA-16-5p Derived From M1 Macrophages Enhances T Cell-Dependent Immune Response by Regulating PD-L1 in Gastric Cancer	70
Mitochondria-Associated Endoplasmic Reticulum Membranes in Cardiovascular Diseases	69
The Neurovascular Unit in Glaucomatous Neurodegeneration	69
Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3): Unraveling the Role in Mediating IGF-Independent Effects Within the Cell	69
Brain Neurotransmitter Modulation by Gut Microbiota in Anxiety and Depression	69
An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer	69
TGF-β Signaling and Resistance to Cancer Therapy	68
Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling	67
Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis	67
MicroRNA-34a: Potent Tumor Suppressor, Cancer Stem Cell Inhibitor, and Potential Anticancer Therapeutic	67
Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities	67
From Flies to Men: ROS and the NADPH Oxidase in Phagocytes	66
Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration	66
Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis	66
Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion	65
Effect of Nuclear Stiffness on Cell Mechanics and Migration of Human Breast Cancer Cells	65
Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy	65
The Application of Brain Organoids: From Neuronal Development to Neurological Diseases	65
B Cell Orchestration of Anti-tumor Immune Responses: A Matter of Cell Localization and Communication	65
LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence	65
Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches	65
Mesenchymal Stromal Cells and Exosomes: Progress and Challenges	64
Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability	64
Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?	64
The Mitochondrial Response to DNA Damage	64
Bone and Muscle Crosstalk in Aging	63
Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis	63
Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges	63
m6A Regulators Is Differently Expressed and Correlated With Immune Response of Esophageal Cancer	63
The Roles of 2-Hydroxyglutarate	63
Multiple Functions of ATG8 Family Proteins in Plant Autophagy	62
Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity	62
H3K4me1 Distribution Predicts Transcription State and Poising at Promoters	61
New Insights Into Targeting Membrane Lipids for Cancer Therapy	61
Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy	61
A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications	61
Exosomes From Adipose-Derived Stem Cells: The Emerging Roles and Applications in Tissue Regeneration of Plastic and Cosmetic Surgery	61
Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome	61
Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective	61
Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons	60
Primary Cilia, Ciliogenesis and the Actin Cytoskeleton: A Little Less Resorption, A Little More Actin Please	60
Ran GTPase: A Key Player in Tumor Progression and Metastasis	60
Cell-Free DNA: Hope and Potential Application in Cancer	60
CircRNA Is a Rising Star in Researches of Ocular Diseases	59
Obesity and Bone Health: A Complex Link	59
Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway	59
Ferroptosis in Acute Central Nervous System Injuries: The Future Direction?	59
Natural Compounds and Autophagy: Allies Against Neurodegeneration	59
The Role of Short-Chain Fatty Acids and Bile Acids in Intestinal and Liver Function, Inflammation, and Carcinogenesis	58
Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs	58
Cancer Stem Cells: Emerging Key Players in Immune Evasion of Cancers	58
Two Types of Contact Between Lipid Droplets and Mitochondria	58

Mechanisms of Oocyte Maturation and Related Epigenetic Regulation	57
A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies	57
Identifying Transcriptomic Signatures and Rules for SARS-CoV-2 Infection	57
Emerging Roles of Exosomal Circular RNAs in Cancer	56
A Novel Ten-Gene Signature Predicting Prognosis in Hepatocellular Carcinoma	56
The Dimensions of Primary Mitochondrial Disorders	56
Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis	56
Down-Regulated Exosomal MicroRNA-221 – 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair	56
Is Senescence-Associated β-Galactosidase a Reliable in vivo Marker of Cellular Senescence During Embryonic Development?	56
Endothelial-to-Mesenchymal Transition in Cancer	56
Mesenchymal Stem Cells Adaptively Respond to Environmental Cues Thereby Improving Granulation Tissue Formation and Wound Healing	56
Exosomal PD-L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies	56
Mitochondrial Function in Muscle Stem Cell Fates	56
Mitochondrial Dynamics in Adult Cardiomyocytes and Heart Diseases	56
Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain	55
USP7 Is a Master Regulator of Genome Stability	55
N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications	55
Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids	55
In vivo Neuroregeneration to Treat Ischemic Stroke Through NeuroD1 AAV-Based Gene Therapy in Adult Non-human Primates	55
Prognostic Significance and Tumor Immune Microenvironment Heterogenicity of m5C RNA Methylation Regulators in Triple-Negative Breast Cancer	55
The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer	55
New Understanding of the Relevant Role of LINE-1 Retrotransposition in Human Disease and Immune Modulation	54
Telomere Replication: Solving Multiple End Replication Problems	54
Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies	54
CD226: An Emerging Role in Immunologic Diseases	54
COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences	54
Regulation of Myostatin on the Growth and Development of Skeletal Muscle	53
Mesenchymal Stromal Cell-Produced Components of Extracellular Matrix Potentiate Multipotent Stem Cell Response to Differentiation Stimuli	53
The MicroRNA Family Gets Wider: The IsomiRs Classification and Role	53
Development and Validation of a Robust Ferroptosis-Related Prognostic Signature in Lung Adenocarcinoma	53
Niches for Skeletal Stem Cells of Mesenchymal Origin	53
HGF and MET: From Brain Development to Neurological Disorders	53
Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure/Function and Cellular Stress Response	53
Mitochondria Donation by Mesenchymal Stem Cells: Current Understanding and Mitochondria Transplantation Strategies	53
Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?	53
Ion Transport in Eryptosis, the Suicidal Death of Erythrocytes	53
Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway	53
The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis	52
Nerves in the Tumor Microenvironment: Origin and Effects	52
Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Lung Diseases: Current Status and Perspectives	52
STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion	52
Global Research Trends of Ferroptosis: A Rapidly Evolving Field With Enormous Potential	52
The Nrf2 Pathway in Liver Diseases	52
Molecular Mechanisms of Chondrocyte Proliferation and Differentiation	52
Fibroblast Senescence in Idiopathic Pulmonary Fibrosis	52
Osteoclast Signal Transduction During Bone Metastasis Formation	52
nCOVID-19 Pandemic: From Molecular Pathogenesis to Potential Investigational Therapeutics	51
Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage	51
Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids	51
The Paradoxical Role of Cellular Senescence in Cancer	51
Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality	51
Roles of N6-Methyladenosine (m6A) in Stem Cell Fate Decisions and Early Embryonic Development in Mammals	51
Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity	51
The Role of Astrocytes in the Neurorepair Process	51
Molecular Crosstalk Between MYC and HIF in Cancer	51
Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine	51
Extracellular Vesicles Derived From Apoptotic Cells: An Essential Link Between Death and Regeneration	51
Membrane-Interacting Antifungal Peptides	50
Identification and Validation of Pyroptosis-Related Gene Signature to Predict Prognosis and Reveal Immune Infiltration in Hepatocellular Carcinoma	50
Vertebrate Sensory Ganglia: Common and Divergent Features of the Transcriptional Programs Generating Their Functional Specialization	50
Emerging Roles of Liquid–Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling	50
A Prognostic Ferroptosis-Related lncRNAs Signature Associated With Immune Landscape and Radiotherapy Response in Glioma	50
Expression of m6A Regulators Correlated With Immune Microenvironment Predicts Therapeutic Efficacy and Prognosis in Gliomas	50
When Stiffness Matters: Mechanosensing in Heart Development and Disease	50
Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors	50
Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart Regeneration	50
Neurovascular Coupling in Development and Disease: Focus on Astrocytes	50
Insights on SARS-CoV-2 Molecular Interactions With the Renin-Angiotensin System	49
LncRNA KCNQ1OT1 Secreted by Tumor Cell-Derived Exosomes Mediates Immune Escape in Colorectal Cancer by Regulating PD-L1 Ubiquitination via MiR-30a-5p/USP22	49
MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-1	49
Exosome-Based Delivery of Natural Products in Cancer Therapy	49
Reactive Oxygen Species: Not Omnipresent but Important in Many Locations	49
Heterochromatin as an Important Driver of Genome Organization	49
Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer	49
Comparative Genomics of Peroxisome Biogenesis Proteins: Making Sense of the PEX Proteins	49
Identification of CDK2-Related Immune Forecast Model and ceRNA in Lung Adenocarcinoma, a Pan-Cancer Analysis	49
Midbrain Organoids: A New Tool to Investigate Parkinson’s Disease	49
The Roles of Epigenetics Regulation in Bone Metabolism and Osteoporosis	49
Recent Update of HDAC Inhibitors in Lymphoma	48
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis	48
Neural Stem Cells and Methods for Their Generation From Induced Pluripotent Stem Cells in vitro	48
Targeting the HGF/MET Axis in Cancer Therapy: Challenges in Resistance and Opportunities for Improvement	47
Induction of Autophagy by Pterostilbene Contributes to the Prevention of Renal Fibrosis via Attenuating NLRP3 Inflammasome Activation and Epithelial-Mesenchymal Transition	47
Neural Stem Cell-Derived Exosomes Regulate Neural Stem Cell Differentiation Through miR-9-Hes1 Axis	47
Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies	47
Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction	47
Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability	46
Pre-metastatic Niche Formation in Different Organs Induced by Tumor Extracellular Vesicles	46
Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy	46
Disease Activity-Associated Alteration of mRNA m5 C Methylation in CD4+ T Cells of Systemic Lupus Erythematosus	46
Structural Characteristics, Binding Partners and Related Diseases of the Calponin Homology (CH) Domain	46
m6A Methylation Regulates Osteoblastic Differentiation and Bone Remodeling	46
Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development	46
Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor—Glioma Therapy?	46
Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant	46