OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Molecular Biosciences is 53. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Editorial: Ironome: a still untapped frontier	273
Position Specific Alternative Splicing and Gene Expression Profiles Along the Tonotopic Axis of Chick Cochlea	258
Ranolazine Inhibits Pyroptosis via Regulation of miR-135b in the Treatment of Diabetic Cardiac Fibrosis	200
A novel pyroptosis-regulated gene signature for predicting prognosis and immunotherapy response in hepatocellular carcinoma	153
Editorial: The Dual-Use Dilemma for Biomimicry	130
Production and characterization of monoclonal antibodies for the detection of the hepatitis C core antigen	123
Editorial: Interactions of nanoparticles with and within living organisms—What can we learn to improve efficacy of nanomedicine?	118
Melasolv™: a potential preventive and depigmenting agent for the senescence of melanocytes	110
Cardiolipin occupancy profiles of YidC paralogs reveal the significance of respective TM2 helix residues in determining paralog-specific phenotypes	106
Mechanosensory encoding dysfunction emerges from cancer-chemotherapy interaction	103
Crystalline Sponge Method by Three-Dimensional Electron Diffraction	103
The Role of the Thioredoxin Detoxification System in Cancer Progression and Resistance	103
Editorial: Analytical devices based on immobilized macromolecules for structural and activity/affinity studies in drug discovery	101
Deepening insights into cholinergic agents for intraocular pressure reduction: systems genetics, molecular modeling, and in vivo perspectives	98
Preparation of RNAs with non-canonical 5′ ends using novel di- and trinucleotide reagents for co-transcriptional capping	93
Integrating network analysis with differential expression to uncover therapeutic and prognostic biomarkers in esophageal squamous cell carcinoma	92
Type-2 diabetes epigenetic biomarkers: present status and future directions for global and Indigenous health	88
Computational Insights Into the Effects of the R190K and N121Q Mutations on the SARS-CoV-2 Spike Complex With Biliverdin	88
Untargeted Metabolomics Studies of H9c2 Cardiac Cells Submitted to Oxidative Stress, β-Adrenergic Stimulation and Doxorubicin Treatment: Investigation of Cardiac Biomarkers	88
ceRNAshiny: An Interactive R/Shiny App for Identification and Analysis of ceRNA Regulation	87
Curcumin-mediated transcriptional regulation of human N-acetylgalactosamine-α2,6-sialyltransferase which synthesizes sialyl-Tn antigen in HCT116 human colon cancer cells	87
Study on the metabolic effects of hexavalent chromium [Cr (VI)] on rat astrocytes using un-targeted metabolomics	84
Drugging Fuzzy Complexes in Transcription	82
Identification of key genes related to growth of largemouth bass (Micropterus salmoides) based on comprehensive transcriptome analysis	80
Editorial: In celebration of women in science: RNA networks and biology	79

The application of exosomes in the treatment of triple-negative breast cancer	78
Corrigendum: Evaluation of PIK3CA mutations in advanced ER+/HER2-breast cancer in Portugal – U-PIK Project	76
Revealing the pharmacological effect and mechanism of darutoside on gouty arthritis by liquid chromatography/mass spectrometry and metabolomics	75
Modeling of pneumococcal serogroup 10 capsular polysaccharide molecular conformations provides insight into epitopes and observed cross-reactivity	71
Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats	71
The chemistry of gut microbiome-derived lipopolysaccharides impacts on the occurrence of food allergy in the pediatric age	70
Characterization of METTL7B to Evaluate TME and Predict Prognosis by Integrative Analysis of Multi-Omics Data in Glioma	66
From in vitro to in silico: a pipeline for generating virtual tissue simulations from real image data	65
Biochemical and Structural Characterization of Thermostable GH159 Glycoside Hydrolases Exhibiting α-L-Arabinofuranosidase Activity	64
miR-3587 Inhibitor Attenuates Ferroptosis Following Renal Ischemia-Reperfusion Through HO-1	62
Transcriptome Sequencing Reveals Key Genes in Three Early Phases of Osteogenic, Adipogenic, and Chondrogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Rats	62
A Conserved Mitochondrial Chaperone-Protease Complex Involved in Protein Homeostasis	62
Corrigendum: RUNX1 Upregulates CENPE to Promote Leukemic Cell Proliferation	62
Interaction of gut microbiota with the tumor microenvironment: A new strategy for antitumor treatment and traditional Chinese medicine in colorectal cancer	61
Moving HER2-low breast cancer predictive and prognostic data from clinical trials into the real world	61
Keeping up with the condensates: The retention, gain, and loss of nuclear membrane-less organelles	61
Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axis	59
Metabolome combined with gut microbiome revealed the lipid-lowering mechanism of Xuezhiping capsule on hyperlipidemic hamster induced by high fat diet	59
Identification of novel gene signatures and immune cell infiltration in intervertebral disc degeneration using bioinformatics analysis	58
Editorial: Novel approaches aiming to overcome current nanomedicine limitations	57
Potential Molecular Targets of Tenofovir Disoproxil Fumarate for Alleviating Chronic Liver Diseases via a Non-Antiviral Effect in a Normal Mouse Model	56
A systematic review reveals conflicting evidence for the prevalence of antibodies against the sialic acid ‘xenoautoantigen’ Neu5Gc in humans and the need for a standardised approach to quantification	56
Two-Metal-Ion Catalysis: Inhibition of DNA Polymerase Activity by a Third Divalent Metal Ion	56
Identification of Crucial Hub Genes and Differential T Cell Infiltration in Idiopathic Pulmonary Arterial Hypertension Using Bioinformatics Strategies	55
Bioinformatics-Guided Analysis Uncovers AOX1 as an Osteogenic Differentiation-Relevant Gene of Human Mesenchymal Stem Cells	55
Pan-Cancer Analysis and Validation Reveals that D-Dimer-Related Genes are Prognostic and Downregulate CD8+ T Cells via TGF-Beta Signaling in Gastric Cancer	55
Enhanced enrichment of extracellular vesicles for laboratory and clinical research from drop-sized blood samples	54
Technical Validation and Clinical Utility of an NGS Targeted Panel to Improve Molecular Characterization of Pediatric Acute Leukemia	54
Machine learning-enhanced insights into sphingolipid-based prognostication: revealing the immunological landscape and predictive proficiency for immunomotherapy and chemotherapy responses in pancreati	53
Implementation of a combined bioinformatics and experimental approach to address lncRNA mechanism of action: The example of NRIR	53