Cancer Immunology Research

Article	Citations
Abstract P039: The immune profile of colorectal and pancreas adenocarcinomas: Differences between central and peripheric tumor regions	173
Abstract P003: Efficacy results of a novel vaccine composed of stimulated and haptenized tumors cells in Balbc mice grafted with murine colon adenocarcinoma CT26 cells	112
A Sampling of Highlights from the Literature	110
A Sampling of Highlights from the Literature	102
Context-Dependent Immunomodulatory Effects of MEK Inhibition Are Enhanced with T-cell Agonist Therapy	96
Exercise as an Immune Boost: Mechanism-Driven Support for Lifestyle Interventions	94
Optimal Neoantigen Cancer Vaccines Target CD8+ and CD4+ T Cells with Multiple Antigens	79
Reciprocal Interactions Between the Gut Microbiome and Mammary Tissue Mast Cells Promote Metastatic Dissemination of HR+ Breast Tumors	73
Transforming the Dark into Light: A Siglec-9 Switch	68
Different PD-L1 Assays Reveal Distinct Immunobiology and Clinical Outcomes in Urothelial Cancer	66
IL18 at the Crossroads between Chronic Inflammation and T-cell Exhaustion in Pancreatic Cancer	66
IL-15 complex enhances agonistic anti-CD40 + anti-PDL1 by correcting the T-bet to Tox ratio in CD8+ T cells infiltrating pancreatic ductal adenocarcinoma	64
A Population of TIM4+FOLR2+ Macrophages Localized in Tertiary Lymphoid Structures Correlates to an Active Immune Infiltrate Across Several Cancer Types	59
The ω-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid Enhances NK-Cell Antitumor Effector Functions	58
Self-Renewing CD8+ T-cell Abundance in Blood Associates with Response to Immunotherapy	57
Host Interactions with Engineered T-cell Micropharmacies	55
T-cell Senescence in the Tumor Microenvironment	55
Preclinical Characterization and Phase I Study of an Anti–HER2-TLR7 Immune-Stimulator Antibody Conjugate in Patients with HER2+ Malignancies	54
CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity	53
Profiling Multiple CD8+ T-cell Functional Dimensions Enhances Breast Cancer Immune Assessment	51
Abstract P009: Correlation between immune modulation of macrophage recruitment and new blood vessel formation in a subcutaneous murine mouse model of colorectal cancer	51
Abstract P073: Gut microbiota shift in melanoma patients undergoing immunotherapy is associated with clinical response	51
Abstract IA17: The power of ONE: Immunology in the age of single cell genomics	50
A Sampling of Highlights from the Literature	49
High Mobility Group Protein B1 Decreases Surface Localization of PD-1 to Augment T-cell Activation	49

Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity	49
Sensory Nerves Impede the Formation of Tertiary Lymphoid Structures and Development of Protective Antimelanoma Immune Responses	48
High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects	47
Engineering CD20 CARs with a Twist	47
Ncoa2 Promotes CD8+ T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function	47
A Sampling of Highlights from the Literature	47
Low TCR Binding Strength Results in Increased Progenitor-like CD8+ Tumor-Infiltrating Lymphocytes	47
Harnessing Microbiota to Improve Immunotherapy for Gastrointestinal Cancers	47
IL11: A Specific Repressor of Tumor-Specific CD4+ T Cells	44
Loss of LRRC33-Dependent TGFβ1 Activation Enhances Antitumor Immunity and Checkpoint Blockade Therapy	44
Neoadjuvant STING Activation, Extended Half-life IL2, and Checkpoint Blockade Promote Metastasis Clearance via Sustained NK-cell Activation	43
KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer	42
The HSP90 Inhibitor Pimitespib Targets Regulatory T Cells in the Tumor Microenvironment	41
Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer	41
Ethnicity, Immunity, and Outcomes: Biology versus Socioeconomic Status	39
Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited	38
The SETDB1–TRIM28 Complex Suppresses Antitumor Immunity	38
CRASH-IT Switch Enables Reversible and Dose-Dependent Control of TCR and CAR T-cell Function	37
Cannabidiol Enhances Atezolizumab Efficacy by Upregulating PD-L1 Expression via the cGAS–STING Pathway in Triple-Negative Breast Cancer Cells	36
A Sampling of Highlights from the Literature	36
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission	35
Abstract P027: Extending intratumoral therapeutic durability using a multivalent immunotherapy platform	34
Abstract P011: B cell subsets that correlate with anti-PD-1 resistance in a preclinical model of HPV+ oropharyngeal cancer	34
Navigating Critical Challenges Associated with Immunopeptidomics-Based Detection of Proteasomal Spliced Peptide Candidates	34
Tumor-Associated CD19+CD39− B Regulatory Cells Deregulate Class-Switch Recombination to Suppress Antibody Responses	33
Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells	33
TMB and Inflammatory Gene Expression Associated with Clinical Outcomes following Immunotherapy in Advanced Melanoma	32
Spatial Organization of Macrophages in CTL-Rich Hepatocellular Carcinoma Influences CTL Antitumor Activity	32
CCRL2 Expression by Specialized Lung Capillary Endothelial Cells Controls NK-cell Homing in Lung Cancer	32
Circulating and Intratumoral Immune Determinants of Response to Atezolizumab plus Bevacizumab in Patients with Variant Histology or Sarcomatoid Renal Cell Carcinoma	32
About the Rising Star	32
Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry	31
A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy	30
Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma	30
PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress	29
Abstract IA07: Impact of immunotherapy on COVID-19 immunity: Insights from checkpoint blockade in cancer	27
Abstract P054: Immune determinants of the association between tumor mutational burden and immunotherapy response across cancer types	27
Abstract IA12: Cancer evolution: Chromosomal instability and immune evasion	27
A Sampling of Highlights from the Literature	26
CXCL10 Recruitment of γδ T Cells into the Hypoxic Bone Marrow Environment Leads to IL17 Expression and Multiple Myeloma Progression	26
Neutralizing Antibodies Impair the Oncolytic Efficacy of Reovirus but Permit Effective Combination with T cell–Based Immunotherapies	26
A Sampling of Highlights from the Literature	26
Determinants for Antitumor and Protumor Effects of Programmed Cell Death	26
Autoantibodies Drive Heart Damage Caused by Concomitant Radiation and PD-1 Blockade	26
The E3 Ubiquitin Ligase FBXO38 Maintains the Antitumor Function of Natural Killer Cells by Sustaining IL15R Signaling	26
Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells	25
Intratumoral TREX1 Induction Promotes Immune Evasion by Limiting Type I IFN	25
CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1	25
Coexisting Alterations of MHC Class I Antigen Presentation and IFNγ Signaling Mediate Acquired Resistance of Melanoma to Post–PD-1 Immunotherapy	25
A Sampling of Highlights from the Literature	25

Battle Within the Sexes: Differences in Male and Female Immunity and the Impact on Antitumor Responses	24
A Sampling of Highlights from the Literature	24
Atypical B Cells Promote Cancer Progression and Poor Response to Bacillus Calmette-Guérin in Non–Muscle Invasive Bladder Cancer	24
NKG7 Is a T-cell–Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy	24
Adenosine-Deaminase-Acting-on-RNA-1 Facilitates T-cell Migration toward Human Melanoma Cells	24
Regulatory Considerations for Genome-Edited T-cell Therapies	23
A Sampling of Highlights from the Literature	23
Translating Science into Survival: Report on the Seventh International Cancer Immunotherapy Conference	23
Inhibitor of Apoptosis Proteins Antagonist Induces T-cell Proliferation after Cross-Presentation by Dendritic Cells	23
Cancer Immunology Research: A Decade of Illumination and Innovation	22
MerTK Induces Dysfunctional Dendritic Cells by Metabolic Reprogramming	22
A Metabolic Axis of Immune Intractability	22
Combination CXCR4 and PD-1 Blockade Enhances Intratumoral Dendritic Cell Activation and Immune Responses Against Hepatocellular Carcinoma	22
Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer	22
Antitumor Immune Responses in B2M-Deficient Cancers	22
A Sampling of Highlights from the Literature	21
Q&A: Lisa H. Butterfield, Elizabeth M. Jaffee, and Arlene H. Sharpe on the SITC–AACR Joint Workshop, “The Cancer Biology Underlying Immunotherapy-Induced Autoimmunity”	21
CD8+ T Cells Keep Their (K+)urrency for Function	21
CAR Binders Affect CAR T-cell Tonic Signaling, Durability, and Sensitivity to Target	21
Abstract IA20: What does not kill it makes it stronger: Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy	20
The PO4-tential for Less Toxic CAR T-cell Therapies	20
Transient EZH2 Suppression by Tazemetostat during In Vitro Expansion Maintains T-Cell Stemness and Improves Adoptive T-Cell Therapy	20
Abstract P057: Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas	20
Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti–PD-1/PD-L1 Agents	20
The Pellino1–PKCθ Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function	20
About the Rising Star	20
Abstract P075: NTX-1088, a potent first-in-class, anti-PVR mAb, restores expression and function of DNAM1 for optimal DNAM1-mediated antitumor immunity	20
TLR5 Signaling Causes Dendritic Cell Dysfunction and Orchestrates Failure of Immune Checkpoint Therapy against Ovarian Cancer	19
Identification of Core Techniques That Enhance Genome Editing of Human T Cells Expressing Synthetic Antigen Receptors	19
M9657 Is a Bispecific Tumor-Targeted Anti-CD137 Agonist That Induces MSLN-Dependent Antitumor Immunity without Liver Inflammation	19
HER2Δ16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer	19
The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I–Associated Peptides	18
Allogeneic CAR T Cells: Complex Cellular Therapy Designs Test the Limits of Our Preclinical Models	18
Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function	18
Abstract IA06: Chimeric antigen receptor macrophages for the treatment of solid tumors	18
Dual Chimeric Antigen Receptor T Cells Targeting CD38 and SLAMF7 with Independent Signaling Demonstrate Preclinical Efficacy and Safety in Multiple Myeloma	18
Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy	18
Glioblastoma Cell–Derived lncRNA-Containing Exosomes Induce Microglia to Produce Complement C5, Promoting Chemotherapy Resistance	18
Abstract P070: The safety and efficacy of Durvalumab and Paclitaxel combination in metastatic triple-negative breast cancer: An open-label phase I/II trial with 2-years follow-up	18
Immune Modulation of Innate and Adaptive Responses Restores Immune Surveillance and Establishes Antitumor Immunologic Memory	18
A Sampling of Highlights from the Literature	18
CD73 Inhibits cGAS–STING and Cooperates with CD39 to Promote Pancreatic Cancer	17
Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells	17
Accounting for B-cell Behavior and Sampling Bias Predicts Anti–PD-L1 Response in Bladder Cancer	17
Low Serum Apolipoprotein A1 Levels Impair Antitumor Immunity of CD8+ T Cells via the HIF-1α–Glycolysis Pathway	17
Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer	17
CD49a Targeting Enhances NK Cell Function and Antitumor Immunity	17
CD4+ Regulatory T Cells in Human Cancer: Subsets, Origin, and Molecular Regulation	17
Abstract P062: PI3Kγδ inhibitor plus radiation enhances the antitumor immune effect of PD-1 blockade in syngenic murine breast cancer and humanized patient-derived xenograft model	16
Small Gene Networks Delineate Immune Cell States and Characterize Immunotherapy Response in Melanoma	16
Let the Guard Down: cAMP Activators Can Improve Immunotherapy in GBM	16
Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer	16
Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function	16
Abstract IA16: Immune suppression in cancer and strategies for its reversal	16
The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain	16
Combination of Anti–PD-1 and Electroacupuncture Induces a Potent Antitumor Immune Response in Microsatellite-Stable Colorectal Cancer	16
Long-Read Sequencing Reveals Alternative Splicing-Driven, Shared Immunogenic Neoepitopes Regardless of SF3B1 Status in Uveal Melanoma	16
About the Rising Star	16
iBRIDGE: A Data Integration Method to Identify Inflamed Tumors from Single-cell RNA-Seq Data and Differentiate Cell Type–Specific Markers of Immune-Cell Infiltration	15
Systemic Alterations in Type-2 Conventional Dendritic Cells Lead to Impaired Tumor Immunity in Pancreatic Cancer	15
The Problem with Syngeneic Mouse Tumor Models	15
TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids	15
Efficacy and Synergy with Cisplatin of an Adenovirus Vectored Therapeutic E1E2E6E7 Vaccine against HPV Genome–Positive C3 Cancers in Mice	15
Tertiary Lymphoid Structures Are Associated with Enhanced Macrophage Activation and Immune Checkpoint Expression and Predict Outcome in Cervical Cancer	15
The Dark Knight: Functional Reprogramming of Neutrophils in the Pathogenesis of Colitis-Associated Cancer	15
Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer	15
The TRIB2–DNMT1 pathway generates an immune cold microenvironment in glioblastoma and its inhibition promotes immunotherapy	15
A γδ T–cell Imprint in a Rare Skin Tumor	15
Tyrosine Kinase Inhibition Activates Intratumoral γδ T Cells in Gastrointestinal Stromal Tumor	14
A Sampling of Highlights from the Literature	14
Host Tissue Factors Predict Immune Surveillance and Therapeutic Outcomes in Gastric Cancer	14
Interactions between MDSCs and the Autonomic Nervous System: Opportunities and Challenges in Cancer Neuroscience	14
Mesenchymal stem cells and fibroblasts contribute to microvascular proliferation in glioblastoma and are correlated with immunosuppression and poor outcome	14
A Sampling of Highlights from the Literature	14
Something Old and Something New to Unleash the Power of Natural Killer Cells against Metastases	14
Imaging of T-cell Responses in the Context of Cancer Immunotherapy	14
Gastric Microbiome Alterations Are Associated with Decreased CD8+ Tissue-Resident Memory T Cells in the Tumor Microenvironment of Gastric Cancer	13
IDO Vaccine Ablates Immune-Suppressive Myeloid Populations and Enhances Antitumor Effects Independent of Tumor Cell IDO Status	13
High-Dimensional Analyses Reveal IL15 Enhances Activation of Sipuleucel-T Lymphocyte Subsets and Reverses Immunoresistance	13
Abstract P068: Automated cell type specific PD-L1 quantification by artificial intelligence using high throughput bleach & stain 15-marker multiplex fluorescence immunohistochemistry in human canc	13

Arginase 1–Based Immune Modulatory Vaccines Induce Anticancer Immunity and Synergize with Anti–PD-1 Checkpoint Blockade	13
Abstract P051: Function of shp-1 and shp-2 phosphatases in T cell-mediated anti-tumor response	13
Abstract P076: Humanized anti-αvβ3 antibody engineered to selectively promote macrophage-mediated cancer cell death	12
CAR T Cells Engineered to Secrete IFNκ Induce Tumor Ferroptosis via an IFNAR/STAT1/ACSL4 Axis	12
Gut Mycobiota Dysbiosis Is Associated with Melanoma and Response to Anti–PD-1 Therapy	12
Targeting cancer-associated glycosylation for adoptive T cell therapy of solid tumors	12
Effective Treatment of Established Bone Metastases Can Be Achieved by Combinatorial Osteoclast Blockade and Depletion of Granulocytic Subsets	12
Breast Cancer Stem Cell–Derived Tumors Escape from γδ T-cell Immunosurveillance In Vivo by Modulating γδ T-cell Ligands	12
CDK2 Inhibition Enhances Antitumor Immunity by Increasing IFN Response to Endogenous Retroviruses	12
Combination IFNβ and Membrane-Stable CD40L Maximize Tumor Dendritic Cell Activation and Lymph Node Trafficking to Elicit Systemic T-cell Immunity	12
Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients	12
Tsyn-Seq: a T-cell Synapse–Based Antigen Identification Platform	12
Regulatory Programs of B-cell Activation and Germinal Center Reaction Allow B-ALL Escape from CD19 CAR T-cell Therapy	12
Inhibition of PIM Kinase in Tumor-Associated Macrophages Suppresses Inflammasome Activation and Sensitizes Prostate Cancer to Immunotherapy	12
FOXO1 Inhibition Generates Potent Nonactivated CAR T Cells against Solid Tumors	12