OOIR: Observatory of International Research

Papers

(The H4-Index of Genes & Diseases is 46. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice	1485
An in-depth analysis of the prognostic significance and potential clinical impact of Leupaxin in the immunotherapeutic treatment of esophageal squamous cell carcinoma	221
Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe	181
Phase separation of Snail1 modulates transcription and cancer progression	180
Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination	158
Expanded insights into the mechanisms of RNA-binding protein regulation of circRNA generation and function in cancer biology and therapy	131
PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes	119
Epigenetics: Mechanisms, potential roles, and therapeutic strategies in cancer progression	119
Patient-derived xenograft models: Current status, challenges, and innovations in cancer research	113
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer	105
Mechanism of PARP inhibitor resistance and potential overcoming strategies	103
Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis	103
Autoantigenic peptide landscape of rheumatoid arthritis-associated HLA class II	101
Development of an orally bioavailable selective inhibitor of the menin-MLL	100
The advancements in organoids: Potential and challenges in researching the esophagus and esophageal squamous cell carcinoma	100
Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia	93
The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development	91
Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)	90
Clinical management of a rare melanoma case arising from congenital melanocytic nevus	78
Wnt genes in colonic polyposis predisposition	75
DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis	75
Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression	71
Sex hormone-binding globulin impedes hepatocellular carcinoma growth via MERTK regulation	70
Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility	70
CCDC178-mediated cytoskeleton assembly is required for spermiogenesis in mice	69

Perturbed microbial ecology in pediatric systemic lupus erythematosus: Evidence from the gut microbiome and serum metabolome	68
BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response	67
Integrating single-cell transcriptomics and machine learning to reveal prognostic and immune significance of lactylation in breast cancer	66
Inflammasome activation and signalling in the ischemic-reperfused myocardium	66
Tryptophan attenuates acute hypoxic stress-induced intestinal injury through the modulation of intestinal barrier integrity and gut microbiota homeostasis	64
Optimized Yamanaka factors combined with TERT gene therapy for enhanced anti-aging effects	64
Exploring the role of FTO in preeclampsia pathogenesis: Insights into m6A modification and decidualization	60
The implication of pyroptosis in cancer immunology: Current advances and prospects	60
lncRNA cytoskeleton regulator RNA (CYTOR): Diverse functions in metabolism, inflammation and tumorigenesis, and potential applications in precision oncology	57
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells	56
The role of TGF-β in the tumor microenvironment of pancreatic cancer	56
SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma	56
MACF1 deficiency suppresses tooth mineralization through IGF1 mediated crosstalk between odontoblasts and ameloblasts	55
LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases	53
Disulfidptosis heterogeneity in breast cancer uncovers PTTG1IP as an actionable therapeutic target	51
Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration	49
Hippo-YAP/TAZ signaling in breast cancer: Reciprocal regulation of microRNAs and implications in precision medicine	49
Sirolimus may improve bile excretion in ABCB11 mutants: A case report of a patient with bile salt export pump deficiency	49
Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization	48
The miR-21-5p enriched in the apoptotic bodies of M2 macrophage-derived extracellular vesicles alleviates osteoarthritis by changing macrophage phenotype	47
Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines	46
DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects	46
Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation	46