OOIR: Observatory of International Research

Papers

(The H4-Index of Genes & Diseases is 48. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes	1642
Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice	251
An in-depth analysis of the prognostic significance and potential clinical impact of Leupaxin in the immunotherapeutic treatment of esophageal squamous cell carcinoma	202
Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)	197
Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility	185
CCDC178-mediated cytoskeleton assembly is required for spermiogenesis in mice	153
Perturbed microbial ecology in pediatric systemic lupus erythematosus: Evidence from the gut microbiome and serum metabolome	133
Development of an orally bioavailable selective inhibitor of the menin-MLL	132
Exploring the role of FTO in preeclampsia pathogenesis: Insights into m6A modification and decidualization	130
Integrating single-cell transcriptomics and machine learning to reveal prognostic and immune significance of lactylation in breast cancer	129
Inflammasome activation and signalling in the ischemic-reperfused myocardium	118
Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination	114
Optimized Yamanaka factors combined with TERT gene therapy for enhanced anti-aging effects	114
Up-regulated IL-36 expression promotes a pro-tumorigenic phenotype in pancreatic ductal adenocarcinoma	109
Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia	106
SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma	95
Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression	86
Phase separation of Snail1 modulates transcription and cancer progression	86
Wnt genes in colonic polyposis predisposition	83
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells	83
UCH-L1 down-regulates HER2 expression and increases lapatinib sensitivity by interacting with HSP90 in HER2-positive breast cancer	82
Clinical management of a rare melanoma case arising from congenital melanocytic nevus	79
BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response	79
The advancements in organoids: Potential and challenges in researching the esophagus and esophageal squamous cell carcinoma	79
The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development	78

DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis	77
The role of TGF-β in the tumor microenvironment of pancreatic cancer	75
Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe	74
lncRNA cytoskeleton regulator RNA (CYTOR): Diverse functions in metabolism, inflammation and tumorigenesis, and potential applications in precision oncology	73
Autoantigenic peptide landscape of rheumatoid arthritis-associated HLA class II	71
Post-translational modifications of influenza virus proteins	66
Impaired neuronal migration of a novel missense variant p.Ile383Val in STXBP1 is potentially relevant to cerebral palsy	65
Epigenetics: Mechanisms, potential roles, and therapeutic strategies in cancer progression	63
Mechanism of PARP inhibitor resistance and potential overcoming strategies	61
Expanded insights into the mechanisms of RNA-binding protein regulation of circRNA generation and function in cancer biology and therapy	58
Patient-derived xenograft models: Current status, challenges, and innovations in cancer research	57
The implication of pyroptosis in cancer immunology: Current advances and prospects	55
Tryptophan attenuates acute hypoxic stress-induced intestinal injury through the modulation of intestinal barrier integrity and gut microbiota homeostasis	54
Intra-tumoral microbiota: Key modulators of tumor immunity and therapeutic potential	53
Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis	52
Loss of homeostatic functions in microglia from a murine model of Friedreich's ataxia	51
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer	51
Integrated bulk and single-cell transcriptome data identify clinically relevant cell populations in clear cell renal cell carcinoma	50
Screening and validation of key metastasis-associated genes in pancreatic cancer using a multi-omics and machine learning approach	49
Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration	49
FAM151A inhibits hepatitis B virus by modulating cccDNA transcriptional activity	49
Disulfidptosis heterogeneity in breast cancer uncovers PTTG1IP as an actionable therapeutic target	49
Histone modifications in cardiovascular diseases: Mechanisms and therapies	49
Single-cell landscape analysis reveals distinct regression trajectories and novel prognostic biomarkers in primary neuroblastoma	48