OOIR: Observatory of International Research

Papers

(The H4-Index of Genes & Diseases is 44. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes	1124
Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe	285
Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility	261
Clinical management of a rare melanoma case arising from congenital melanocytic nevus	147
Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination	145
CCDC178-mediated cytoskeleton assembly is required for spermiogenesis in mice	135
Exploring the role of FTO in preeclampsia pathogenesis: Insights into m6A modification and decidualization	132
Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice	118
Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)	109
Expanded insights into the mechanisms of RNA-binding protein regulation of circRNA generation and function in cancer biology and therapy	105
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer	94
The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development	93
The role of TGF-β in the tumor microenvironment of pancreatic cancer	87
BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response	81
DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis	81
The advancements in organoids: Potential and challenges in researching the esophagus and esophageal squamous cell carcinoma	78
Autoantigenic peptide landscape of rheumatoid arthritis-associated HLA class II	77
SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma	77
Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression	76
Sex hormone-binding globulin impedes hepatocellular carcinoma growth via MERTK regulation	75
Integrative analysis reveals the clinical utility of cancer-associated fibroblast-derived signature, and its implication for young-onset thyroid cancer	74
Patient-derived xenograft models: Current status, challenges, and innovations in cancer research	69
lncRNA cytoskeleton regulator RNA (CYTOR): Diverse functions in metabolism, inflammation and tumorigenesis, and potential applications in precision oncology	65
Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia	63
Wnt genes in colonic polyposis predisposition	63

Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis	62
Tryptophan attenuates acute hypoxic stress-induced intestinal injury through the modulation of intestinal barrier integrity and gut microbiota homeostasis	60
Epigenetics: Mechanisms, potential roles, and therapeutic strategies in cancer progression	58
Phenotypic characterization of patients with activated PI3Kδ syndrome 1 presenting with features of systemic lupus erythematosus	56
Mechanism of PARP inhibitor resistance and potential overcoming strategies	55
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells	54
The implication of pyroptosis in cancer immunology: Current advances and prospects	52
Development of an orally bioavailable selective inhibitor of the menin-MLL	52
A heterozygous N-terminal truncation mutation of NFKBIA results in an impaired NF-κB dependent inflammatory response	52
Loss of homeostatic functions in microglia from a murine model of Friedreich's ataxia	50
Mitochondrial transplantation in lung diseases: From mechanisms to application prospects	47
Platinum-resistant ovarian cancer: From mechanisms to treatment strategies	47
A peptide-based assay discriminates individual antibody response to SARS-CoV-2	46
HBV sL13H mutation impairs its surface antigen expression and ability to induce autophagy	45
EBF1 expressed in the dermal papilla regulates hair type and length	45
PD-L1 expression and smoke exposure as biomarkers for optimizing adjuvant therapy for patients with resected limited-stage small-cell lung carcinoma	45
Disulfidptosis heterogeneity in breast cancer uncovers PTTG1IP as an actionable therapeutic target	45
Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration	45
Overactivation of histone deacetylases and EZH2 in Wilms tumorigenesis	44
Defective biological networks associated with pseudogene-derived lncRNAs in cancer drug resistance: Promising prospects for their clinical targets in cancer therapy	44