OOIR: Observatory of International Research

Papers

(The H4-Index of Genes & Diseases is 40. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes	913
BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response	253
Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe	230
Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility	128
Clinical management of a rare melanoma case arising from congenital melanocytic nevus	120
Development of an orally bioavailable selective inhibitor of the menin-MLL	117
Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination	114
Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice	108
Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression	96
Sex hormone-binding globulin impedes hepatocellular carcinoma growth via MERTK regulation	86
The implication of pyroptosis in cancer immunology: Current advances and prospects	81
Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis	79
Exploring the role of FTO in preeclampsia pathogenesis: Insights into m6A modification and decidualization	78
The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development	76
SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma	74
Autoantigenic peptide landscape of rheumatoid arthritis-associated HLA class II	73
Optimized Yamanaka factors combined with TERT gene therapy for enhanced anti-aging effects	72
The advancements in organoids: Potential and challenges in researching the esophagus and esophageal squamous cell carcinoma	71
Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)	70
CCDC178-mediated cytoskeleton assembly is required for spermiogenesis in mice	68
Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia	61
Wnt genes in colonic polyposis predisposition	58
An In-depth Analysis of the Prognostic Significance and Potential Clinical Impact of Leupaxin in the Immunotherapeutic Treatment of Esophageal Squamous Cell Carcinoma	58
Phenotypic characterization of patients with activated PI3Kδ syndrome 1 presenting with features of systemic lupus erythematosus	57
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer	57

DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis	54
Mechanism of PARP inhibitor resistance and potential overcoming strategies	53
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells	53
Epigenetics: Mechanisms, potential roles, and therapeutic strategies in cancer progression	50
The role of TGF-β in the tumor microenvironment of pancreatic cancer	50
lncRNA cytoskeleton regulator RNA (CYTOR): Diverse functions in metabolism, inflammation and tumorigenesis, and potential applications in precision oncology	49
Expanded insights into the mechanisms of RNA-binding protein regulation of circRNA generation and function in cancer biology and therapy	49
MACF1 deficiency suppresses tooth mineralization through IGF1 mediated crosstalk between odontoblasts and ameloblasts	46
PRR11 induces filopodia formation and promotes cell motility via recruiting ARP2/3 complex in non-small cell lung cancer cells	46
AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells in vivo	46
Disulfidptosis heterogeneity in breast cancer uncovers PTTG1IP as an actionable therapeutic target	44
A peptide-based assay discriminates individual antibody response to SARS-CoV-2	44
Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation	43
Single-cell analysis reveals the lncRNA-MEG3/miRNA-133a-3p/PRRT2 axis regulates skeletal muscle regeneration and myogenesis	43
Tirzepatide, a dual GIP/GLP-1 receptor agonist, alleviates metabolic dysfunction-associated steatotic liver disease by reducing the expression of CD36 and OBP2A	41
BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations	40
DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects	40