OOIR: Observatory of International Research

Papers

(The H4-Index of Genes & Diseases is 46. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice	1267
An in-depth analysis of the prognostic significance and potential clinical impact of Leupaxin in the immunotherapeutic treatment of esophageal squamous cell carcinoma	306
Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe	278
Expanded insights into the mechanisms of RNA-binding protein regulation of circRNA generation and function in cancer biology and therapy	168
Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia	151
Autoantigenic peptide landscape of rheumatoid arthritis-associated HLA class II	150
Integrative analysis reveals the clinical utility of cancer-associated fibroblast-derived signature, and its implication for young-onset thyroid cancer	144
Development of an orally bioavailable selective inhibitor of the menin-MLL	125
Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)	116
Clinical management of a rare melanoma case arising from congenital melanocytic nevus	104
Wnt genes in colonic polyposis predisposition	102
BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response	91
DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis	90
Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression	88
Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility	87
Sex hormone-binding globulin impedes hepatocellular carcinoma growth via MERTK regulation	86
PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes	84
Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells	83
CCDC178-mediated cytoskeleton assembly is required for spermiogenesis in mice	78
SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma	77
Perturbed microbial ecology in pediatric systemic lupus erythematosus: Evidence from the gut microbiome and serum metabolome	77
The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development	72
Exploring the role of FTO in preeclampsia pathogenesis: Insights into m6A modification and decidualization	71
lncRNA cytoskeleton regulator RNA (CYTOR): Diverse functions in metabolism, inflammation and tumorigenesis, and potential applications in precision oncology	67
Epigenetics: Mechanisms, potential roles, and therapeutic strategies in cancer progression	66

The implication of pyroptosis in cancer immunology: Current advances and prospects	63
UCH-L1 down-regulates HER2 expression and increases lapatinib sensitivity by interacting with HSP90 in HER2-positive breast cancer	60
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer	60
Intra-tumoral microbiota: Key modulators of tumor immunity and therapeutic potential	58
Up-regulated IL-36 expression promotes a pro-tumorigenic phenotype in pancreatic ductal adenocarcinoma	58
Mechanism of PARP inhibitor resistance and potential overcoming strategies	57
Patient-derived xenograft models: Current status, challenges, and innovations in cancer research	56
Tryptophan attenuates acute hypoxic stress-induced intestinal injury through the modulation of intestinal barrier integrity and gut microbiota homeostasis	54
The role of TGF-β in the tumor microenvironment of pancreatic cancer	54
Loss of homeostatic functions in microglia from a murine model of Friedreich's ataxia	53
Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination	53
Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis	53
The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer	52
LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases	52
DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects	51
Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface: Towards a pre-clinical model of periodontal diseases and personalized periodont	50
Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation	49
The USP7 protein interaction network and its roles in tumorigenesis	49
Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization	49
Mitochondrial transplantation in lung diseases: From mechanisms to application prospects	46
Hippo-YAP/TAZ signaling in breast cancer: Reciprocal regulation of microRNAs and implications in precision medicine	46