OOIR: Observatory of International Research

Papers

(The H4-Index of Genes & Diseases is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
A patient with glycogen storage disease type IA combined with hepatic adenoma: A case report	648
Transcriptomic characterization of posterior capsule, anterior capsule, and femoral condylar tissue highlights tissue-specific microenvironments in knee osteoarthritis	335
Synergistic anti-tumor activity of ciclopirox olamine and metformin in triple-negative breast cancer	214
The same genomic variants in the first three exons of KANSL1 can be either benign or causative of Koolen-de Vries syndrome: Definition of a validation procedure	193
Elucidating the maternal and fetal metabolic and immune landscapes of gestational diabetes mellitus with a pan-organ transcriptomic atlas	98
Identifying functional subtypes and common mechanisms of rheumatoid arthritis and systemic lupus erythematosus	97
Patient-derived xenograft models: Current status, challenges, and innovations in cancer research	96
Fibroblast growth factor 8: Multifaceted Role in Development and Developmental Disorder	82
Targeting STARD4/EGFR axis inhibits growth and overcomes lenvatinib resistance in hepatocellular carcinoma	78
Exogenous pyruvate is therapeutic against colitis by targeting cytosolic phospholipase A2	74
SIRT5 promotes the osteo-inductive potential of BMP9 by stabilizing the HIF-1α protein in mouse embryonic fibroblasts	74
Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia	71
CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury	71
Aquaporin-3 promotes proliferation and inflammation in hepatocellular carcinoma	71
Identification of cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants	69
DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis	64
Structure, function, and pathology of Neurexin-3	63
Development of an orally bioavailable selective inhibitor of the menin-MLL	61
PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes	59
A novel structural variant of RET causes familial Hirschsprung's disease via nonsense-mediated mRNA decay	59
Etiological roles of core promoter variation in triple-negative breast cancer	56
lncRNA cytoskeleton regulator RNA (CYTOR): Diverse functions in metabolism, inflammation and tumorigenesis, and potential applications in precision oncology	55
MAL2 DNA methylation serves as a biomarker for the diagnosis and prognosis of glioma	55
Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)	53
Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy	53

PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis	48
EBV-Mir-BART5-5p targets p53 independent pathway in cytoplasm: Potential role in EBV lymphomagenesis	46
Cancer exploits a late premetazoan gene module conserved in the human genome	45
Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma	45
Wnt genes in colonic polyposis predisposition	45
Herpesviral interplay with peroxisome: An underexplored viral niche	43
BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response	43
Deletion of G protein-coupled receptor 116 enhances neutrophil function and aggravates lung injury in mice	43
Prevention and treatment of gerbil hepatitis E using the programmable CRISPR-Cas13d system	42
LncRNA HOTTIP facilitated tumor growth via stimulating the hnRNPA2B1/DKK1/Wnt/β-catenin regulatory axis in hepatocellular carcinoma	42
Resident to exhausted CD4+ T cell ratio is associated with the prognosis of gastric cancer	40
Epigenetics: Mechanisms, potential roles, and therapeutic strategies in cancer progression	39
Transcriptomic and machine learning analyses identify hub genes of metabolism and host immune response that are associated with the progression of breast capsular contracture	39