OOIR: Observatory of International Research

Papers

(The TQCC of Regenerative Therapy is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Applications of 3D printed bone tissue engineering scaffolds in the stem cell field	100
Advances in regenerative therapy: A review of the literature and future directions	89
Research progress in decellularized extracellular matrix-derived hydrogels	80
First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol	73
Mesenchymal stem cell-based tissue regeneration therapies for periodontitis	67
Immune evasion by cancer stem cells	64
Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles	52
Degenerative osteoarthritis a reversible chronic disease	50
Three dimensional printed nanostructure biomaterials for bone tissue engineering	48
Adipose-derived stem cells improve tendon repair and prevent ectopic ossification in tendinopathy by inhibiting inflammation and inducing neovascularization in the early stage of tendon healing	41
Implantation of allogenic umbilical cord blood-derived mesenchymal stem cells improves knee osteoarthritis outcomes: Two-year follow-up	38
Stem cell therapy for osteonecrosis of femoral head: Opportunities and challenges	33
Comparison of therapeutic effects of encapsulated Mesenchymal stem cells in Aloe vera gel and Chitosan-based gel in healing of grade-II burn injuries	32
Co-cultured spheroids of human periodontal ligament mesenchymal stem cells and vascular endothelial cells enhance periodontal tissue regeneration	27
Biologically modified implantation as therapeutic bioabsorbable materials for bone defect repair	26
Exosomes from adipose-derived stem cells protect against high glucose-induced erectile dysfunction by delivery of corin in a streptozotocin-induced diabetic rat model	26
Platelet-rich plasma promotes recruitment of macrophages in the process of tendon healing	25
TGF-β1-containing exosomes derived from bone marrow mesenchymal stem cells promote proliferation, migration and fibrotic activity in rotator cuff tenocytes	25
Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche	24
The application of bone marrow mesenchymal stem cells and biomaterials in skeletal muscle regeneration	23
Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature	22
miRNA signaling networks in cancer stem cells	22
iPSC for modeling neurodegenerative disorders	22
Molecular pathology underlying the robustness of cancer stem cells	20
Effect of peripheral blood-derived mesenchymal stem cells on macrophage polarization and Th17/Treg balance in vitro	20

LncRNA MALAT1 promotes wound healing via regulating miR-141-3p/ZNF217 axis	20
The promising rise of bioprinting in revolutionalizing medical science: Advances and possibilities	19
Biosynthesis, characterization and evaluation of the supportive properties and biocompatibility of DBM nanoparticles on a tissue-engineered nerve conduit from decellularized sciatic nerve	18
Current status of ischemic stroke treatment: From thrombolysis to potential regenerative medicine	18
Mesenchymal stem cell extracellular vesicles-derived microRNA-194-5p delays the development of intervertebral disc degeneration by targeting TRAF6	17
Role of platelet rich plasma mediated repair and regeneration of cell in early stage of cardiac injury	17
A cancer invasion model of cancer-associated fibroblasts aggregates combined with TGF-β1 release system	16
Osteochondral regeneration using scaffold-free constructs of adipose tissue-derived mesenchymal stem cells made by a bio three-dimensional printer with a needle-array in rabbits	16
Dexmedetomidine protects PC12 cells from ropivacaine injury through miR-381/LRRC4 /SDF-1/CXCR4 signaling pathway	16
Fabrication of Biologically Inspired Electrospun Collagen/Silk fibroin/bioactive glass composited nanofibrous scaffold to accelerate the treatment efficiency of bone repair	15
A silk fibroin/chitosan/nanohydroxyapatite biomimetic bone scaffold combined with autologous concentrated growth factor promotes the proliferation and osteogenic differentiation of BMSCs and repair of	15
Human umbilical cord mesenchymal stem cell-derived exosomes promote neurological function recovery in rat after traumatic brain injury by inhibiting the activation of microglia and astrocyte	15
Chitosan-cartilage extracellular matrix hybrid scaffold induces chondrogenic differentiation to adipose-derived stem cells	15
Dental pulp-derived stem cell-conditioned media attenuates secondary Sjögren's syndrome via suppression of inflammatory cytokines in the submandibular glands	15
Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers	15
Development of an efficient vitrification method for chondrocyte sheets for clinical application	14
Repair of spinal cord injury in rats via exosomes from bone mesenchymal stem cells requires sonic hedgehog	14
Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis	14
Identification of neurospheres generated from human dental pulp stem cells in xeno-/serum-free conditions	14
New insight of immuno-engineering in osteoimmunomodulation for bone regeneration	14
Basic fibroblast growth factor enhances proliferation and hepatocyte growth factor expression of feline mesenchymal stem cells	14
miR-503/Apelin-12 mediates high glucose-induced microvascular endothelial cells injury via JNK and p38MAPK signaling pathway	14
Proteomic analysis of platelet-rich and platelet-poor plasma	14
Dental pulp stem cells response on the nanotopography of scaffold to regenerate dentin-pulp complex tissue	14
Current regenerative medicine-based approaches for skin regeneration: A review of literature and a report on clinical applications in Japan	13
A pair of cell preservation solutions for therapy with human adipose tissue-derived mesenchymal stromal cells	13
Human bone marrow mesenchymal stem cell-derived exosomes containing microRNA-425 promote migration, invasion and lung metastasis by down-regulating CPEB1	13
Investigating the Impact of Collagen-Chitosan Derived from Scomberomorus Guttatus and Shrimp Skin on Second-Degree Burn in Rats Model	13
Regenerative potential of pluripotent nontumorgenetic stem cells: Multilineage differentiating stress enduring cells (Muse cells)	13
Polyurethane foam for skin graft fixation in clinical-relevant ovine burn wound model for wound repair and regeneration research	13
Assessment of human bioengineered cardiac tissue function in hypoxic and re-oxygenized environments to understand functional recovery in heart failure	13
Liver cancer stem cells: Recent progress in basic and clinical research	12
The protective mechanism of Klotho gene-modified bone marrow mesenchymal stem cells on acute kidney injury induced by rhabdomyolysis	12
Heparin-conjugated collagen as a potent growth factor-localizing and stabilizing scaffold for regenerative medicine	12
Preparation of antibody-immobilized gelatin nanospheres incorporating a molecular beacon to visualize the biological function of macrophages	12
An exploratory clinical trial to evaluate the safety and efficacy of combination therapy of REGROTH® and Cytrans® granules for severe periodontitis with intrabony defects	12
Safety and efficacy of bone marrow derived-mesenchymal stem cells transplantation in patients with amyotrophic lateral sclerosis	12
Three-dimensional spheroids of dedifferentiated fat cells enhance bone regeneration	12
Extracellular microvesicles that originated adipose tissue derived mesenchymal stem cells have the potential ability to improve rheumatoid arthritis on mice	12
Biodistribution studies for cell therapy products: Current status and issues	12
Fibronectin-coating enhances attachment and proliferation of mesenchymal stem cells on a polyurethane meniscal scaffold	12
Recovery of sensory function after the implantation of oriented-collagen tube into the resected rat sciatic nerve	11
Establishment of an efficient ex vivo expansion strategy for human natural killer cells stimulated by defined cytokine cocktail and antibodies against natural killer cell activating receptors	11
Immunosuppressive mesenchymal stem cells aggregates incorporating hydrogel microspheres promote an in vitro invasion of cancer cells	11
Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy	11
A stable protocol for the fabrication of transplantable human oral mucosal epithelial cell sheets for clinical application	11
Viability evaluation of layered cell sheets after ultraviolet light irradiation of 222 nm	10
CircRNA_25487 inhibits bone repair in trauma-induced osteonecrosis of femoral head by sponging miR-134-3p through p21	10
In vitro effects of conditioned medium from bioreactor cultured human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on skin-derived cell lines	10
Are mesenchymal stem cells able to manage cytokine storm in COVID-19 patients? A review of recent studies	10

Novel device prototyping for endoscopic cell sheet transplantation using a three-dimensional printed simulator	10
Cancer stem cell-like cells-derived exosomal lncRNA CDKN2B-AS1 promotes biological characteristics in thyroid cancer via miR-122-5p/P4HA1 axis	10
Pluripotent stem cell-derived retinal organoid/cells for retinal regeneration therapies: A review	10
Inorganic polyphosphate in platelet rich plasma accelerates re-epithelialization in vitro and in vivo	10
Mesenchymal stem cell therapy: A review of clinical trials for multiple sclerosis	10
Gelatin hydrogel nonwoven fabrics of a cell culture scaffold to formulate 3-dimensional cell constructs	10
Mesenchymal stem cell-derived extracellular vesicles/exosome: A promising therapeutic strategy for intracerebral hemorrhage	9
Cryoprotective enhancing effect of very low concentration of trehalose on the functions of primary rat hepatocytes	9
Low-temperature extrusion-based 3D printing of icariin-laden scaffolds for osteogenesis enrichment	9
Targeting cancer stem cells in refractory cancer	9
Mesenchymal stem cells pretreated with proinflammatory cytokines accelerate skin wound healing by promoting macrophages migration and M2 polarization	9
Conversion of mesenchymal stem cells into a canine hepatocyte-like cells by Foxa1 and Hnf4a	9
Efficient cell transplantation combining injectable hydrogels with control release of growth factors	9
Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats	9
The hsa-miR-302 cluster controls ectodermal differentiation of human pluripotent stem cell via repression of DAZAP2	9
Effect of cell seeding methods on the distribution of cells into the gelatin hydrogel nonwoven fabric	9
Ameliorated healing of biliary anastomosis by autologous adipose-derived stem cell sheets	9
Role of quercetin and rutin in enhancing the therapeutic potential of mesenchymal stem cells for cold induced burn wound	8
Advanced Therapy medicinal products for autologous chondrocytes and comparison of regulatory systems in target countries	8
Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell–cell interactions underlying the bone repair process	8
Hyaluronic acid hydrogels crosslinked via blue light-induced thiol-ene reaction for the treatment of rat corneal alkali burn	8
Regenerative medicine for the upper gastrointestinal tract	8
Nrf2 is required for suppressing osteoclast RANKL-induced differentiation in RAW 264.7 cells via inactivating cannabinoid receptor type 2 with AM630	8
Cryopreservation of undifferentiated and differentiated human neuronal cells	8
A case series of platelet rich plasma in chronic venous ulcers	8
A technique for removing tumourigenic pluripotent stem cells using rBC2LCN lectin	8
Optimization of culture duration of bone marrow cells before transplantation with a β-tricalcium phosphate/recombinant collagen peptide hybrid scaffold	7
Evaluation of the post-treatment anti-inflammatory capacity of osteoarthritic chondrocytes: An in vitro study using baicalein	7
PPAR-δ agonist affects adipo-chondrogenic differentiation of human mesenchymal stem cells through the expression of PPAR-γ	7
External administration of moon jellyfish collagen solution accelerates physiological wound healing and improves delayed wound closure in diabetic model mice	7
Laminin-511-derived recombinant fragment and Rho kinase inhibitor Y-27632 facilitate serial cultivation of keratinocytes differentiated from human embryonic stem cells	7
Facial nerve regeneration with bioabsorbable collagen conduits filled with collagen filaments: An experimental study	7
A novel cardiac differentiation method of a large number and uniformly-sized spheroids using microfabricated culture vessels	7
A review and update for registered clinical studies of stem cells for non-tumorous and non-hematological diseases	7
Effects of conditioned medium obtained from human adipose-derived stem cells on skin inflammation	7
Safety study of allogeneic mesenchymal stem cell therapy in animal model	7
Urinary bladder reconstruction using autologous collagenous connective tissue membrane “Biosheet®” induced by in-body tissue architecture: A pilot study	7
Addition of Chk1 inhibitor and BMP4 cooperatively promotes retinal tissue formation in self-organizing human pluripotent stem cell differentiation culture	7
Combination therapy of Juzentaihoto and mesenchymal stem cells attenuates liver damage and regresses fibrosis in mice	7
Progress of esophageal stricture prevention after endoscopic submucosal dissection by regenerative medicine and tissue engineering	7
Prognostic factors affecting periodontal regenerative therapy using recombinant human fibroblast growth factor-2: A 3-year cohort study	7
Successful engraftment of epithelial cells derived from autologous rabbit buccal mucosal tissue, encapsulated in a polymer scaffold in a rabbit model of a urethral stricture, transplanted using the tr	7
Development of appropriate fatty acid formulations to raise the contractility of constructed myocardial tissues	7
Characterization of autologous platelet rich plasma (PRP) and its biological effects in patients with Behçet's Disease	7
Circ_0087960 stabilizes KDM5B by reducing SKP2 mediated ubiquitination degradation and promotes osteogenic differentiation in periodontal ligament stem cells	7
RUNX3 derived hsa_circ_0005752 accelerates the osteogenic differentiation of adipose-derived stem cells via the miR-496/MDM2-p53 pathway	7
Bone formation potential of collagen type I-based recombinant peptide particles in rat calvaria defects	7