OOIR: Observatory of International Research

Papers

(The TQCC of Regenerative Therapy is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Pathogenesis and potential therapeutic application of stem cells transplantation in Huntington’s disease	113
Hypoxia inducible factor-1α mediates the mechanism of the Hedgehog pathway in tendinopathy repair by Asperosaponin VI	105
Study on promoting the regeneration of grafted fat by cell-assisted lipotransfer	86
Gelatin hydrogel nonwoven fabrics of a cell culture scaffold to formulate 3-dimensional cell constructs	61
Transplantation of acellularized dermis matrix (ADM) plus fully covered metal stent to prevent stricture after circumferential endoscopic submucosal dissection of early esophageal cancer (with video)	56
Editorial Board	37
Naringenin promotes angiogenesis of ischemic myocardium after myocardial infarction through miR-223-3p/IGF1R axis	33
Two-stage skin grafting using a basic fibroblast growth factor-impregnated artificial dermis	33
Clinical course of more than 10 years in a patient with extensive skin burns who received cultured epidermal autograft transplantation	32
Gliko BMSC: A potential strategy of treatment for renal fibrosis	30
Editorial Board	28
Effect of silk fibroin scaffold loaded with 17-β estradiol on the proliferation and differentiation of BMSCs	27
Editorial Board	27
Development of a novel regenerative therapy for malignant bone tumors using an autograft containing tumor inactivated by high hydrostatic pressurization (HHP)	27
Relationship between oxygen partial pressure and inhibition of cell aggregation of human adipose tissue-derived mesenchymal stem cells stored in cell preservation solutions	26
Effect of morphological change on the maturation of human induced pluripotent stem cell-derived cardiac tissue in rotating flow culture	25
Treatment of giant congenital melanocytic nevi with cultured epithelial autografts: Clinical and histopathological analysis	24
Collagen type I-based recombinant peptide promotes bone regeneration in rat critical-size calvarial defects by enhancing osteoclast activity at late stages of healing	24
Exosomal microRNA-Based therapies for skin diseases	24
Haruhiko Noda – First reporter of collagen fibrillar aggregates formed from solubilized rat tail collagen	23
Enhancement of therapeutic potential of mesenchymal stem cell by IGF-1 delivery in PLGA microspheres for tissue regeneration	21
Baseline magnetic resonance imaging findings associated with short-term clinical outcomes after intraarticular administration of autologous adipose-derived stem cells for knee osteoarthritis	20
Comparative gastrointestinal organoid models across species: A Zoobiquity approach for precision medicine	19
Stable preparation of in vivo transplantable periodontal ligament-derived mesenchymal stem cell sheets in thermoresponsive culture dishes with tunable cell detachability	19
Functional characterization and therapeutic potential of human umbilical cord blood mononuclear cells	18

The role of GATA4 in mesenchymal stem cell senescence: A new frontier in regenerative medicine	18
Editorial Board	18
MAPT-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis	17
Canine adipose-derived mesenchymal stromal cells inhibit the growth of canine hematologic malignancy cell lines	17
Establishment of feline embryonic stem cells from the inner cell mass of blastocysts produced in vitro	17
Modeling vascular dynamics at the initial stage of endochondral ossification on a microfluidic chip using a human embryonic-stem-cell-derived organoid	17
CD73-positive pediatric urethral mesenchymal stem-like cell-derived small extracellular vesicles stimulate angiogenesis	16
miRNA signaling networks in cancer stem cells	16
TAF15 regulates the BRD4/GREM1 axis and activates the gremlin-1-NF-κB pathway to promote OA progression	16
Evaluation of pharmacokinetics and safety of a long-term estradiol-releasing stent in rat uterine	16
Effects of plasma rich in growth factors on wound healing in patients with venous ulcers	15
Attitudes towards human fetal tissue research: Survey of researchers and the public in Japan	15
Anti-apoptotic and autophagic effect: Using conditioned medium from human bone marrow mesenchymal stem cells to treat human trabecular meshwork cells	15
Bulk RNA sequencing reveals the comprehensive genetic characteristics of human cord blood-derived natural killer cells	15
Effect of disinfectants and manual wiping for processing the cell product changeover in a biosafety cabinet	15
Rapid and chronological expression of angiogenetic genes is a major mechanism involved in cell sheet transplantation in a rat gastric ulcer model	15
Raman spectroscopy to assess the differentiation of bone marrow mesenchymal stem cells into a glial phenotype	15
Restrictions on monetary payments for human biological substances in Japan: The mu-shou principle and its ethical implications for stem cell research	15
Developing engineered muscle tissues utilizing standard cell culture plates and mesenchymal stem cell-conditioned medium	14
Evaluation of cleaning methods for change-over after the processing of cell products to avoid cross-contamination risk	14
Estradiol enhanced neuronal plasticity and ameliorated astrogliosis in human iPSC-derived neural models	14
Adipose-derived stem cells ameliorate radiation-induced lung injury by activating the DDAH1/ADMA/eNOS signaling pathway	14
Introduction of tenomodulin by gene transfection vectors for rat bone tissue regeneration	13
Synergistic effect and molecular mechanism of nicotinamide and UM171 in ex vivo expansion of long-term hematopoietic stem cells	13
Comparison of the 2021 International Society for Stem Cell Research (ISSCR) guidelines for “laboratory-based human stem cell research, embryo research, and related research activities” and the corresp	13
Development of new bioabsorbable implants with de novo adipogenesis	13
Xenotransplantation of cryopreserved human clumps of mesenchymal stem cells/extracellular matrix complexes pretreated with IFN-γ induces rat calvarial bone regeneration	13
Electrical stimulation induced pre-vascularization of engineered dental pulp tissue	13
Return to the original sport at only 3 months after an Achilles tendon rupture by a combination of intra-tissue injection of freeze-dried platelet-derived factor concentrate and excessively early reha	12
Potential of gelatin hydrogel nonwoven fabrics (Genocel) as a skin substitute in a diabetic mouse skin defect model	12
Stress and motivation of cell processing operators: A pilot study of an online questionnaire survey	12
Circ_ROBO2/miR-186-5p/TRIM14 axis regulates oxidized low-density lipoprotein-induced cardiac microvascular endothelial cell injury	11
Dynamic tracking of human umbilical cord mesenchymal stem cells (hUC-MSCs) following intravenous administration in mice model	11
Granulocyte differentiation of rat bone marrow resident C-kit+ hematopoietic stem cells induced by mesenchymal stem cells could be considered as new option in cell-based therapy	11
Chronic prosthesis-related residual limb ulcer treated with autologous micro-fragmented adipose tissue	11
Bridging potential of Taurine-loading PCL conduits transplanted with hEnSCs on resected sciatic nerves	11
NPWTi allows safe delayed free flap repair of Gustilo IIIb injuries: A prospective case series	11
CircRNA PVT1 modulated cell migration and invasion through Epithelial-Mesenchymal Transition (EMT) mediation in gastric cancer through miR-423-5p/Smad3 pathway	11
Dried human-cultured epidermis accelerates wound healing in a porcine partial-thickness skin defect model	11
MEK inhibitor PD0325901 upregulates CD34 expression in endothelial cells via inhibition of ERK phosphorylation	10
Personalized tissue-engineered arteries as vascular graft transplants: A safety study in sheep	10
Diverting the food-freezing technology improves the cryopreservation efficiency of induced pluripotent stem cells and derived neurospheres	10
Effective regeneration of rat sciatic nerve using nanofibrous scaffolds containing rat ADSCs with controlled release of rhNGF and melatonin molecules for the treatment of peripheral injury model	10
The generation of islet-like insulin-producing cells from Wharton's jelly-derived mesenchymal stem cells on the PES/fish gelatin scaffold	10
Prospect of 3D bioprinting over cardiac cell therapy and conventional tissue engineering in the treatment of COVID-19 patients with myocardial injury	10
Transplantation of autologous bone marrow–derived mononuclear cells into cerebrospinal fluid in a canine model of spinal cord injury	10
Research status of facial nerve repair	10
Clinical outcomes of periodontal regenerative therapy with carbonate apatite granules for treatments of intrabony defects, Class II and Class III furcation involvements: A 9-month prospective pilot cl	10
The therapeutic effect of sufficient oxygen-rich PRP injection in facial rejuvenation by multiple objective evaluations in 26 cases	9
Effects of human induced pluripotent stem cell-derived intestinal organoids on colitis-model mice	9

The application of retinal organoids in ophthalmic regenerative medicine: A mini-review	9
CRISPR/Cas9 and AAV mediated insertion of β2 microglobulin-HLA-G fusion gene protects mesenchymal stromal cells from allogeneic rejection and potentiates the use for off-the-shelf cell therapy	9
Modified human skin cell isolation protocol and its influence on keratinocyte and melanocyte culture	9
Xeno-free workflow exhibits comparable efficiency and quality of keratinocytes isolated from human skin biopsies	9
Research progress in decellularized extracellular matrix-derived hydrogels	9
Regenerative therapy by using mesenchymal stem cells-derived exosomes in COVID-19 treatment. The potential role and underlying mechanisms	9
Stem cell assisted low-intensity shockwave for erectile dysfunction treatment: Current perspective	9
Exosomes from preconditioned mesenchymal stem cells: Tissue repair and regeneration	9
Positive effect of Periostin on repair of Isopreternol induced ischemic damaged cardiomyocyte: an in vitro model	9
Laser emission at 675 nm: In vitro study evidence of a promising role in skin rejuvenation	9
Allogeneic fibroblast sheets prevent pulmonary air leaks caused by rat pleural defects without adhesion to the thoracic wall	8
Development of appropriate fatty acid formulations to raise the contractility of constructed myocardial tissues	8
Clinical challenges of short bowel syndrome and the path forward for organoid-based regenerative medicine	8
Functional changes of cocultured hepatocyte sheets subjected to continuous liver regeneration stimulation in cDNA-uPA/SCID mouse: Differences in transplantation sites	8
Extracellular vesicles derived from HuMSCs alleviate daunorubicin-induced cardiac microvascular injury via miR-186-5p/PARP9/STAT1 signal pathway	8
Efficient cell transplantation combining injectable hydrogels with control release of growth factors	8
Small extracellular vesicles derived from auricular chondrocytes promote secretion of interleukin 10 in bone marrow M1-like macrophages	8
Editorial Board	8
Canine induced pluripotent stem cells efficiently differentiate into definitive endoderm in 3D cell culture conditions using high-dose activin A	8
Establishment of a mouse organ culture model of fetal cleft lip for the evaluation of adipose-derived stem cell therapy	8
Polydopamine-coated biomimetic bone scaffolds loaded with exosomes promote osteogenic differentiation of BMSC and bone regeneration	8
MiR-495-3p depletion contributes to myocardial ischemia/reperfusion injury in cardiomyocytes by targeting TNC	8
Novel cell therapy with ex vivo cultured peripheral blood mononuclear cells significantly impacts angiogenesis in the murine ischemic limb model	8
MiRNA-218 inhibits cell proliferation, migration and invasion by targeting Runt-related transcription factor 2 (Runx2) in human osteosarcoma cells	8
A new clinical classification and reconstructive strategy for post-sternotomy surgical site infection	8
Enhanced recellularization by using albumin coating with roller bottle cell culture	8
Investigation of L-carnitine effects on CD44+ cancer stem cells from MDA-MB-231 breast cancer cell line as anti-cancer therapy	8
Appropriate pore size for bone formation potential of porous collagen type I-based recombinant peptide	8
Preface to the special issue of “Regenerative therapy”: “Future of regenerative medicine viewed by young scientists”	8
Modeling human congenital disorders with neural crest developmental defects using patient-derived induced pluripotent stem cells	7
Automated measurement of fluorescence signals reveals a significant increase of the graft-derived neurite extension in neonates compared to aged rats	7
Tracheal replacement with aortic grafts: Bench to clinical practice	7
Adipogenesis of bioabsorbable implants under irradiation in a rodent model	7
Long term observation of de novo adipogenesis using novel bioabsorbable implants with larger size in a porcine model	7
Bi-functional KIT-PR1P peptides combine with VEGF to protect ischemic kidney in rats by targeting to Kim-1	7
Secretome as neuropathology-targeted intervention of Parkinson’s disease	7
Safety study of allogeneic mesenchymal stem cell therapy in animal model	7
Effects of combined application of fibroblast growth factor (FGF)-2 and carbonate apatite for tissue regeneration in a beagle dog model of one-wall periodontal defect	7
Extracellular vesicles originating from the mechanical microenvironment in the pathogenesis and applications for cardiovascular diseases	7
A comparative analysis of attitudes toward stem cell research and regenerative medicine between six countries – A pilot study	7
Characterization of autologous platelet rich plasma (PRP) and its biological effects in patients with Behçet's Disease	7
Circ_0018168 inhibits the proliferation and osteogenic differentiation of fibroblasts in ankylosing spondylitis via regulating miR-330-3p/DKK1 axis	7
Intrauterine injection of bioengineered hydrogel loaded exosomes derived from HUCM stem cells and spermidine prominently augments the pregnancy rate in thin endometrium rats	7
External administration of moon jellyfish collagen solution accelerates physiological wound healing and improves delayed wound closure in diabetic model mice	7
Scanning electron microscopy analysis of synovial and adipose mesenchymal stem cells adhering to cartilage	7
Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell–cell interactions underlying the bone repair process	7
Investigating the effect of mesenchymal stem cells on the rate of clinical and pathological improvement of asthmatic lung in mouse model	7
Tissue engineering and stem cell-based therapeutic strategies for premature ovarian insufficiency	6
Comparative study of differentiating human pluripotent stem cells into vascular smooth muscle cells in hydrogel-based culture methods	6
Simultaneous binding of bFGF to both FGFR and integrin maintains properties of primed human induced pluripotent stem cells	6
Safety and feasibility of locoregional platelet-rich plasma injection for iliopsoas impingement after total hip arthroplasty: A phase 1 prospective observational study	6
Operator-derived particles and falling bacteria in biosafety cabinets	6
Advances in the study of tissue-engineered retinal pigment epithelial cell sheets	6
The promising rise of bioprinting in revolutionalizing medical science: Advances and possibilities	6
Corrigendum to “Biologically modified implantation as therapeutic bioabsorbable materials for bone defect repair” [Regen Ther 19 (2022) 9–23]	6
Clinical outcomes of guided tissue regeneration with carbonate apatite granules and poly(lactic acid/caprolactone) membrane for the treatment of intrabony defects and mandibular Class II furcation inv	6
Reprogramming canine cryopreserved hepatocytes to hepatic progenitor cells using small molecule compounds	6
MiRNA-320a-5p contributes to the homeostasis of osteogenesis and adipogenesis in bone marrow mesenchymal stem cell	6
Characterization of the cellular heterogeneity and bone regenerative potential of cultured human periosteal cells	6
Multipotent adult progenitor cells prevent functional impairment and improve development in inflammation driven detriment of preterm ovine lungs	6
Mesenchymal cells support the early retention of primary alveolar type 2 cells on acellular mouse lung scaffolds	6
In vitro effects of conditioned medium from bioreactor cultured human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on skin-derived cell lines	6
Superior bone regenerative properties of carbonate apatite with locational bone-active factors through an inorganic process	6
Revolutionizing renal research: The future of kidney-on-a-chip in biotechnology	6
Exploring SSEA3 as an emerging biomarker for assessing the regenerative potential of dental pulp-derived stem cells	6
Topical application of a hyaluronic acid-based hydrogel integrated with secretome of human mesenchymal stromal cells for diabetic ulcer repair	6
Advanced methods to mechanically isolate stromal vascular fraction: A concise review	6
Evaluation of the effect of co-transplantation of collagen-hydroxyapatite bio-scaffold containing nanolycopene and human endometrial mesenchymal stem cell derived exosomes to regenerate bone in rat cr	6
Biological characteristics of Muse cells derived from MenSCs and their application in acute liver injury and intracerebral hemorrhage diseases	6
The immature platelet fraction affects the efficacy of platelet rich plasma therapy for knee osteoarthritis	6
RETRACTED: Preclinical assessment of transplantable human nasal mucosal epithelial cell sheets	6