Cellular and Molecular Gastroenterology and Hepatology

Article	Citations
Contents	183
NRF2 Controls the Competitive Fitness of Squamous Epithelial Cells in the Mouse Esophagus	83
Ptpn2: A Critical Regulator of Paneth Cell Homeostasis	83
Pathophysiological Roles of Ductular Reaction in Liver Inflammation and Hepatic Fibrogenesis	76
Cover	76
Should I Stay or Should I Go – ERK as Control Lever in Hepatocyte Expansion	72
Location Matters: Mitochondrial Arginase 2 as a Treatment for Metabolic Disease?	72
Mucosal-Associated Invariant T Cells in the Digestive System: Defender or Destroyer?	69
Gut-innervating TRPV1+ Neurons Drive Chronic Visceral Pain via Microglial P2Y12 Receptor	68
Development of Human Gut Organoids With Resident Tissue Macrophages as a Model of Intestinal Immune Responses	68
Autophagy Regulates Esophageal Epithelial Renewal	67
Interindividual Variation in Gut Nitrergic Neuron Density Is Regulated By GDNF Levels and ETV1	66
T Cell Repertoire Homogeneity and Blood-Gut Overlap in Patients With Inflammatory Bowel Disease	63
New Immune Role for Axin1 in Colon Cancer Suppression	59
Macrophage Nogo-B Drives Liver Fibrosis	59
In Vivo Genome-Wide CRISPR Activation Screening Identifies Functionally Important Long Noncoding RNAs in Hepatocellular Carcinoma	59
Loss of Brg1 and Pten in Pancreatic Ductal Cells Forms Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway	58
Targeting Ferroptosis Restores the Antiviral Activity of CD8+ T Cells During Chronic Hepatitis B Virus Infection	58
Contents	57
Long-term Temporal Stability of Peripheral Blood DNA Methylation Profiles in Patients With Inflammatory Bowel Disease	57
Role of Nox4 in Mitigating Inflammation and Fibrosis in Dextran Sulfate Sodium–Induced Colitis	54
RBPJ Deficiency Sensitizes Pancreatic Acinar Cells to KRAS-Mediated Pancreatic Intraepithelial Neoplasia Initiation	53
Geranylgeranyl Pyrophosphate Promotes Hepatic Lipid Accumulation by Prenylation of Perilipin4	53
Cover	49
Stratifin Is Necessary for Spasmolytic Polypeptide-Expressing Metaplasia Development After Acute Gastric Injury	48

The Placode Lineage Contributes to the Enteric Nervous System: A Caution for Cell Transplantation Therapy for Hirschsprung Disease	47
Liver-specific Bcl3 Knockout Alleviates Acetaminophen-induced Liver Injury by Activating Nrf2 Pathway in Male Mice	45
PFKFB3-mediated Pro-glycolytic Shift in Hepatocellular Carcinoma Proliferation	44
HIRA in Hepatitis B Virus Minichromosome Regulation: Another Piece of the Puzzle	44
Glia Maturation Factor-β Supports Liver Regeneration by Remodeling Actin Network to Enhance STAT3 Proliferative Signals	44
STIM1 Deficiency In Intestinal Epithelium Attenuates Colonic Inflammation and Tumorigenesis by Reducing ER Stress of Goblet Cells	43
Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model	42
A Dual-Compartment Scaffolding Role for RACK1 in Hepatic Glucagon Signaling and Gluconeogenesis	41
Cover	40
The Interplay of TGF-β1 and Cholesterol Orchestrating Hepatocyte Cell Fate, EMT, and Signals for HSC Activation	40
NF-κB Inducing Kinase Attenuates Colorectal Cancer by Regulating Noncanonical NF-κB Mediated Colonic Epithelial Cell Regeneration	40
Trypsin-Mediated Sensitization to Ferroptosis Increases the Severity of Pancreatitis in Mice	40
In vivo CRISPR Activation Screening, a Powerful Tool to Discover Oncogenic Driver Genes in Hepatocellular Carcinoma	39
C-Reactive Protein, a Promising Approach for Acetaminophen Hepatotoxicity	38
Normalization of Cystic Fibrosis Immune System Reverses Intestinal Neutrophilic Inflammation and Significantly Improves the Survival of Cystic Fibrosis Mice	38
Interplay of Gut Microbes and Aryl Hydrocarbon Receptor in Alcohol-Associated Liver Disease	38
Contents	38
Editorial Board	38
CDKN2A-p16 Deletion and Activated KRASG12D Drive Barrett’s-Like Gland Hyperplasia-Metaplasia and Synergize in the Development of Dysplasia Precancer Lesions	37
The Transcriptomic Landscape of the Human Intestine	37
Desmoplakin Maintains Transcellular Keratin Scaffolding and Protects From Intestinal Injury	35
PHLDB2 Mediates Cetuximab Resistance via Interacting With EGFR in Latent Metastasis of Colorectal Cancer	35
Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-κB Signaling	35
Ferroptosis: A Novel Target to Rescue CD8+ T Cells Against Hepatitis B Virus	35
Anti-prion Antibody Ameliorates Metabolic Dysfunction-associated Steatohepatitis in Mice	34
Extrinsic Innervation of Myenteric Plexus of Human Large Intestine Via Colonic Nerves	34
Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development	33
Continuous Activation of C/EBPβ Transcription Factor Prevents Fibrosis Resolution After Alcohol Cessation	33
Contents	33
PFKFB4 Drives the Oncogenicity in TP53-Mutated Hepatocellular Carcinoma in a Phosphatase-Dependent Manner	32
CREB Fuels Tumorigenesis in Alcoholic Pancreatitis	32
Activation and Spatial Redistribution of RNA Splicing Factors Trigger Hepatic Regeneration	32
Metabolic Regulation of Macrophages by SIRT1 Determines Activation During Cholestatic Liver Disease in Mice	31
Ablation of Sympathetic Nerve-β3 Adrenergic Receptor-mediated Adipose Tissue Lipolysis Attenuates Alcohol-induced Liver Injury in Mice	31
GDF15 Ameliorates Liver Fibrosis by Metabolic Reprogramming of Macrophages to Acquire Anti-Inflammatory Properties	31
Sonic Hedgehog and WNT Signaling Regulate a Positive Feedback Loop Between Intestinal Epithelial and Stromal Cells to Promote Epithelial Regeneration	31
A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach	30
Contents	30
Editorial Board	30
KDM6A/B Demethylases in Gut Homeostasis	30
Editorial Board	30
Siglec-H-/- Plasmacytoid Dendritic Cells Protect Against Acute Liver Injury by Suppressing IFN-γ/Th1 Response and Promoting IL-21+ CD4 T Cells	29
Selective Elimination of NRF2-Activated Cells by Competition With Neighboring Cells in the Esophageal Epithelium	28
Androgen Enhances Aflatoxin-induced Genotoxicity and Inflammation to Liver Cancer in Male Hepatitis B Patients	28
MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by Protecting the Mucosal Epithelial Barrier	28
Histamine Signaling Is Essential for Tissue Macrophage Differentiation and Suppression of Bacterial Overgrowth in the Stomach	28
Myosin Light Chain 9 Mediates Graft Fibrosis After Pediatric Liver Transplantation Through TLR4/MYD88/NF-κB Signaling	28
Targeting Tumor Stroma in CMS4 Colorectal Cancer: Phospholamban Takes Center Stage	27
Moving Up a NOTCH: Defining the Stem Cell Niche in the Gastric Antrum	27
Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and Cholangiocarcinoma	27

Interplay Between Drug-Induced Liver Injury and Gut Microbiota: A Comprehensive Overview	26
When Liver Slices Meet Single-Cell Technology	26
Linking of Senescence to Autophagy Deficiency in Chronic Liver Disease	26
Microbial Players in Primary Sclerosing Cholangitis: Current Evidence and Concepts	26
Hepatocytes Are Resistant to Cell Death From Canonical and Non-Canonical Inflammasome-Activated Pyroptosis	26
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis	26
Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene	26
Calcium Channel α2δ1 is Essential for Pancreatic Tumor-Initiating Cells through Sequential Phosphorylation of PKM2	26
The Protective Role of DDIT4 in Helicobacter pylori-induced Gastric Metaplasia Through Metabolic Regulation of Ferroptosis	26
Contents	25
Editorial Board	25
Interferon-γ Signaling in Eosinophilic Esophagitis Affects Epithelial Barrier Function and Programmed Cell Death	24
Innate Lymphoid Cells: New Culprits of Alcohol-Associated Steatohepatitis	24
Wnt Signaling Silences GUCY2C Hormones in Colorectal Cancer	24
Cover	24
DNMT3B Alleviates Liver Steatosis Induced by Chronic Low-grade LPS via Inhibiting CIDEA Expression	24
Contents	24
Oxidized HMGB1 Adducts Unleash Inflammation in Alcohol-Associated Liver Disease	24
Purinergic Pathways in the Spinal Microglia as a Putative Target for Treatment of Chronic Abdominal Pain	23
Scaffolding Supports the Hippo	23
A Balancing Act: GRHL3 Limits WNT Signaling to Promote Tissue Homeostasis in the Esophageal Epithelium	23
Liver Traffic Jam: How Sinusoidal Congestion Rewires Macrophage Distribution via CXCL9	22
Congestion Enriches Intra-hepatic Macrophages Through Reverse Zonation of CXCL9 in Liver Sinusoidal Endothelial Cells	22
Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin–Mediated Mitophagy	22
Increased Motility and Suppression of Ex Vivo–Expanded Regulatory T Cells Designed for Adoptive Transfer Therapy in Ulcerative Colitis	21
From Muscle to Macrophage: An Anti-inflammatory Role for the Metabolite N-lactoyl-phenylalanine in Inflammatory Bowel Disease	21
Microbiota-dependent Formylated Peptide Receptor (Fpr1/2) Signaling Regulates Enteric Nervous System Development and Gastrointestinal Motility in Mice	21
Intrahepatic Exhausted Antiviral Immunity in an Immunocompetent Mouse Model of Chronic Hepatitis B	21
Presence of Intact Hepatitis B Virions in Exosomes	21
Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity	21
SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis	21
Targeting the Cell Biology of MYO5B Loss in MVID	20
Caffeine Limits Expansion of Apc-Deficient Clones in the Intestine by NOTUM Inhibition	20
PKMζ, a Brain-specific PKCζ Isoform, is Required for Glycolysis and Myofibroblastic Activation of Hepatic Stellate Cells	20
Cover - Blocking BRP39 Alters the Course of Liver Inflammation	20
CMGH: Evolving to Advance Gastroenterology and Hepatology Research	20
Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-Induced Liver Injury in Aged Mice	20
Irritable Bowel Syndrome With Diarrhea in Pediatric Patients Is Associated With Type 2 and Type 9 T Cells in the Intestinal Mucosa	20
Genetic Ablation of C/EBPα-p300 Pathway Blocks Development of Obese Pregnancy Associated Liver Disorders in Offspring	19
Telocyte Recruitment During the Emergence of a Metaplastic Niche in the Stomach	19
Cellular Crosstalk Promotes Hepatic Progenitor Cell Proliferation and Stellate Cell Activation in 3D Co-culture	19
Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis	19
Vitamin D Receptor Activation Targets ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Hepatocytes in Cholestasic Mice	19
Targeting USP9X–AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma	19
TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models	19
Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases	19
Genetic Variation Between Small Bowel and Colon-Predominant Crohn's Disease	19
Notch-Driven Cholangiocarcinogenesis Involves the Hippo Pathway Effector TAZ via METTL3-m6A-YTHDF1	19
Colitis-Induced Small Intestinal Hypomotility Is Dependent on Enteroendocrine Cell Loss in Mice	19
Actinomyces odontolyticus: From Carries to Colorectal Cancer	18
FGL2–MCOLN3-Autophagy Axis–Triggered Neutrophil Extracellular Traps Exacerbate Liver Injury in Fulminant Viral Hepatitis	18
Cellular Interactions and Crosstalk Facilitating Biliary Fibrosis in Cholestasis	18
Rapid Research, High Impact: CMGH’s Short-Form Initiative	18
Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis	18
Correction	18
Interferon Signaling Alters Epithelial Function in Eosinophilic Esophagitis	18
Fueling HCC Dynamics: Interplay Between Tumor Microenvironment and Tumor Initiating Cells	18
Rethinking Immune Check Point Inhibitors Use in Liver Transplantation: Implications and Resistance	18
Cover 1 - Mechanistic Insights Into Colonic Motor Patterns	18
The miR-23b/27b/24-1 Cluster Inhibits Hepatic Fibrosis by Inactivating Hepatic Stellate Cells	18
All Good Things Come to an End: 5 Years at the Helm of CMGH	18
Oxaliplatin-Resistant Hepatocellular Carcinoma Drives Immune Evasion Through PD-L1 Up-Regulation and PMN-Singular Recruitment	17
Reply	17
Wild-type APC Influences the Severity of Familial Adenomatous Polyposis	17
Cyclin-dependent Kinase 9 as a Potential Target for Anti-TNF-resistant Inflammatory Bowel Disease	17
Osr1 Is a Critical Regulator of Macrophage Polarization in NASH Progression	17
Beyond Regulation of Acid Secretion: A Novel Role for Histamine in Gastric Macrophage Differentiation and Function	17
Autophagy-Related Activation of Hepatic Stellate Cells Reduces Cellular miR-29a by Promoting Its Vesicular Secretion	17
On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity	17
Can Psyllium Alleviate Colitis?	17
Correction	17
Pioneer Factor Foxa2 Mediates Chromatin Conformation Changes for Activation of Bile Acid Targets of FXR	16
PFKFB4 Is a Metabolic Driver of HCC Progression and Chemoresistance Through ROS Mitigation	16
Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal Inflammation	16
The STING That Tames Pro-inflammatory T-cells	16
Mrgprb2-dependent Mast Cell Activation Plays a Crucial Role in Acute Colitis	16
Editorial Board	16
Activation of Proneuronal Transcription Factor Ascl1 in Maternal Liver Ensures a Healthy Pregnancy	16
HBV X Protein Induces Degradation of UBXN7, a Novel Negative Regulator of NF-κB Signaling, to Promote HBV Replication	16
Editorial Board	16

Improving Gastric Motility in Aging Through EZH2 Inhibition and Preservation of Interstitial Cells of Cajal	16
Differential MYC Phosphorylation Drives the Divergent Cholangiocyte Response to Stress	16
Etomidate Improves Antitumor Immunity by Suppressing PD-L1 Expression in Hepatocellular Carcinoma Cells	16
Unraveling the Oncogenic Characteristics of the Cytolinker, Plectin, in Esophageal Squamous Cell Carcinoma	16
UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett’s Progression to Esophageal Adenocarcinoma	16
Macrophage COX2 Mediates Efferocytosis, Resolution Reprogramming, and Intestinal Epithelial Repair	16
Bone Loss in Intestinal Inflammation Disease Yields to Osteoclastogenesis Inhibition	16
Hepatic Ketogenesis Regulates Lipid Homeostasis via ACSL1-mediated Fatty Acid Partitioning	16
2’-Fucosyllactose Ameliorates Chemotherapy-Induced Intestinal Mucositis by Protecting Intestinal Epithelial Cells Against Apoptosis	15
D-amino Acids Ameliorate Experimental Colitis and Cholangitis by Inhibiting Growth of Proteobacteria: Potential Therapeutic Role in Inflammatory Bowel Disease	15
Editorial Board	15
Surgery for Crohn’s Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts	15
Neurotensin Regulates Proliferation and Stem Cell Function in the Small Intestine in a Nutrient-Dependent Manner	15
Assessing Long-Term Liver Safety of Statins and PCSK9 Inhibitors Using Human Genetics	15
A Dual Role of HGF-ERK Signaling in IL6/HGF-induced Hepatocyte Proliferation	15
Novel Fat Taste Receptor Agonists Curtail Progressive Weight Gain in Obese Male Mice	15
BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation	15
Stroma New Tune: Emerging Role of PKA in Maintaining Gastric Homeostasis	15
Alterations in Cytoskeleton and Mitochondria in the Development and Reversal of Steatosis in Human Hepatocytes	15
NFATc1 Is a Central Mediator of EGFR-Induced ARID1A Chromatin Dissociation During Acinar Cell Reprogramming	14
DNA 6mA Demethylase ALKBH1 Orchestrates Fatty Acid Metabolism and Suppresses Diet-Induced Hepatic Steatosis	14
Platelets in Alcohol-Associated Liver Disease: Interaction With Neutrophils	14
FACI Is a Novel CREB-H–Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity	14
Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colitis via Governing Tuft Cell Homeostasis	14
Stromal Cell Regulation of Intestinal Inflammatory Fibrosis	14
HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate	14
Rethinking Fibrosis Regression in Alcohol-associated Liver Disease Through C/EBPβ Inhibition	14
Phosphocreatine Rescues Intestinal Epithelial Metabolic Dysfunction Related to Creatine Kinase Loss and Is Protective in Murine Colitis	14
GPAT1 Deficiency in Mice Modulates NASH Progression in a Model-Dependent Manner	14
Liver PP2A-Cα Protects From Parenteral Nutrition-associated Hepatic Steatosis	13
Dietary Selection Pressures and Their Impact on the Gut Microbiome	13
Genome-wide CRISPR Screening Identifies NFκB and c-MET as Druggable Targets to Sensitize Lenvatinib Treatment in Hepatocellular Carcinoma	13
A Reflux Linked GATA Factor Fulcrum Dictates Lineage Commitment Through GPRC5B During the Esophageal Dysplastic Transition	13
The Alpha-Lipoic Acid Improves Glucose Metabolism and Hyperinsulinemia in Acute Intermittent Porphyria: A Nutritional Concept for the Management of Rare Disorders	13
TOC	13
Intestinal Stearoyl-CoA Desaturase-1 Regulates Energy Balance via Alterations in Bile Acid Homeostasis	13
IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B	13
Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in Mice	12
Innate Immune Regulation: ABHD17 Is Calling NOD2 Back From Duty	12
HNRNPM Regulates HCC Tumorigenesis and Cancer Stemness: Identification of a Novel Therapeutic Target?	12
Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem Cells	12
Chronic Inflammation in Ulcerative Colitis Causes Long-Term Changes in Goblet Cell Function	12
CREB Drives Acinar to Ductal Cells Reprogramming and Promotes Pancreatic Cancer Progression in Preclinical Models of Alcoholic Pancreatitis	12
Sphingosine Kinase 1 – A Therapeutic Opportunity for Alleviating Liver Fibrosis?	12
Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived Model	12
Reflux, Reprogramming, and Progenitor Fate: Reframing the Origins of Esophageal Dysplasia	12
Colorectal 15-Lipoxygenase-1 as a Host Factor Determining the Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Colorectal Tumorigenesis in Mice	12
Dysregulation of the Environmental Sensor Aryl Hydrocarbon Receptor Affects Differentiation of Human Colon Organoids	12
Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease	12
Hepatitis B Virus Utilizes a Retrograde Trafficking Route via the Trans-Golgi Network to Avoid Lysosomal Degradation	12
Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic Hepatitis	12
Long Noncoding RNA uc173 is a Novel Regulator of Mitochondrial Metabolism Driving Intestinal Mucosal Growth	11
Escherichia fergusonii Promotes Nonobese Nonalcoholic Fatty Liver Disease by Interfering With Host Hepatic Lipid Metabolism Through Its Own msRNA 23487	11
Actin Filaments in Primary Hepatocytes	11
Response to Spontaneous Cholemia in C57BL/6 Mice Predisposes to Liver Cancer in NASH	11
The Ties That Bind: Enteric Glia Link T Cells to Plexitis in Crohn’s	11
Nothing but NET: A Novel Model of Alcohol Induced Acute-on-Chronic Liver Failure Demonstrates Both Enhanced Mechanistic Insight and a Possible Therapeutic Pathway	11
Uncertain Beginnings: Acinar and Ductal Cell Plasticity in the Development of Pancreatic Cancer	11
Imperatorin Alleviates Intestinal Fibrosis by Suppressing AIM2-mediated GSDMD Pyroptosis in Macrophages	11
Cover - Pcks9 Inhibition Impacts Hepatic Ischemic-Reperfusion Injury	11
In the Enteric Nervous System, It’s All About Connections	11
Correction	11
Parenteral Nutrition Associated Hepatic Steatosis and NAFLD Intersect at AMPK	11
Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome	11
Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell Niche	11
Cover 1 - NRF2-Activated Cells Are Eliminated From Esophagus	11
Contents	11
Gastrointestinal Tract Homeostasis: The Role of the Inositol Polyphosphate Multikinase	11
PRRX1 Has Functional Roles in Pancreatic Acinar to Ductal Metaplasia and Carcinogenesis	11
Introducing Article Numbering to Cellular and Molecular Gastroenterology and Hepatology	11