Cellular and Molecular Gastroenterology and Hepatology

Article	Citations
Cover	198
Interindividual Variation in Gut Nitrergic Neuron Density Is Regulated By GDNF Levels and ETV1	95
Pathophysiological Roles of Ductular Reaction in Liver Inflammation and Hepatic Fibrogenesis	91
Should I Stay or Should I Go – ERK as Control Lever in Hepatocyte Expansion	87
NRF2 Controls the Competitive Fitness of Squamous Epithelial Cells in the Mouse Esophagus	80
New Immune Role for Axin1 in Colon Cancer Suppression	79
Ptpn2: A Critical Regulator of Paneth Cell Homeostasis	76
Contents	75
Location Matters: Mitochondrial Arginase 2 as a Treatment for Metabolic Disease?	73
Mucosal-Associated Invariant T Cells in the Digestive System: Defender or Destroyer?	73
T Cell Repertoire Homogeneity and Blood-Gut Overlap in Patients With Inflammatory Bowel Disease	70
Targeting Ferroptosis Restores the Antiviral Activity of CD8+ T Cells During Chronic Hepatitis B Virus Infection	70
Development of Human Gut Organoids With Resident Tissue Macrophages as a Model of Intestinal Immune Responses	67
In Vivo Genome-Wide CRISPR Activation Screening Identifies Functionally Important Long Noncoding RNAs in Hepatocellular Carcinoma	64
Macrophage Nogo-B Drives Liver Fibrosis	62
Gut-innervating TRPV1+ Neurons Drive Chronic Visceral Pain via Microglial P2Y12 Receptor	61
Autophagy Regulates Esophageal Epithelial Renewal	60
Cilk1 Is Essential for Mesenchymal Cilia Maintenance and Epithelial-mesenchymal Crosstalk in Intestinal Villus Morphogenesis	60
Loss of Brg1 and Pten in Pancreatic Ductal Cells Forms Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway	60
Geranylgeranyl Pyrophosphate Promotes Hepatic Lipid Accumulation by Prenylation of Perilipin4	59
Cover	57
HIRA in Hepatitis B Virus Minichromosome Regulation: Another Piece of the Puzzle	54
PFKFB3-mediated Pro-glycolytic Shift in Hepatocellular Carcinoma Proliferation	53
RBPJ Deficiency Sensitizes Pancreatic Acinar Cells to KRAS-Mediated Pancreatic Intraepithelial Neoplasia Initiation	52
Contents	52

Role of Nox4 in Mitigating Inflammation and Fibrosis in Dextran Sulfate Sodium–Induced Colitis	50
Liver-specific Bcl3 Knockout Alleviates Acetaminophen-induced Liver Injury by Activating Nrf2 Pathway in Male Mice	49
Cover	49
The Interplay of TGF-β1 and Cholesterol Orchestrating Hepatocyte Cell Fate, EMT, and Signals for HSC Activation	48
Glia Maturation Factor-β Supports Liver Regeneration by Remodeling Actin Network to Enhance STAT3 Proliferative Signals	48
STIM1 Deficiency In Intestinal Epithelium Attenuates Colonic Inflammation and Tumorigenesis by Reducing ER Stress of Goblet Cells	47
Long-term Temporal Stability of Peripheral Blood DNA Methylation Profiles in Patients With Inflammatory Bowel Disease	47
The Placode Lineage Contributes to the Enteric Nervous System: A Caution for Cell Transplantation Therapy for Hirschsprung Disease	46
Trypsin-Mediated Sensitization to Ferroptosis Increases the Severity of Pancreatitis in Mice	46
A Dual-compartment Scaffolding Role for Receptor for Activate C Kinase 1 in Hepatic Glucagon Signaling and Gluconeogenesis	46
Stratifin Is Necessary for Spasmolytic Polypeptide-Expressing Metaplasia Development After Acute Gastric Injury	45
Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model	44
Cover	42
NF-κB Inducing Kinase Attenuates Colorectal Cancer by Regulating Noncanonical NF-κB Mediated Colonic Epithelial Cell Regeneration	42
Extrinsic Innervation of Myenteric Plexus of Human Large Intestine Via Colonic Nerves	41
C-Reactive Protein, a Promising Approach for Acetaminophen Hepatotoxicity	40
The Transcriptomic Landscape of the Human Intestine	40
Editorial Board	40
Contents	40
Activation and Spatial Redistribution of RNA Splicing Factors Trigger Hepatic Regeneration	39
Anti-prion Antibody Ameliorates Metabolic Dysfunction-associated Steatohepatitis in Mice	39
CREB Fuels Tumorigenesis in Alcoholic Pancreatitis	39
Contents	39
PFKFB4 Drives the Oncogenicity in TP53-Mutated Hepatocellular Carcinoma in a Phosphatase-Dependent Manner	39
Ferroptosis: A Novel Target to Rescue CD8+ T Cells Against Hepatitis B Virus	38
Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-κB Signaling	38
Normalization of Cystic Fibrosis Immune System Reverses Intestinal Neutrophilic Inflammation and Significantly Improves the Survival of Cystic Fibrosis Mice	38
CDKN2A-p16 Deletion and Activated KRASG12D Drive Barrett’s-Like Gland Hyperplasia-Metaplasia and Synergize in the Development of Dysplasia Precancer Lesions	37
Desmoplakin Maintains Transcellular Keratin Scaffolding and Protects From Intestinal Injury	36
Ablation of Sympathetic Nerve-β3 Adrenergic Receptor-mediated Adipose Tissue Lipolysis Attenuates Alcohol-induced Liver Injury in Mice	36
Interplay of Gut Microbes and Aryl Hydrocarbon Receptor in Alcohol-Associated Liver Disease	35
In vivo CRISPR Activation Screening, a Powerful Tool to Discover Oncogenic Driver Genes in Hepatocellular Carcinoma	34
Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development	34
PHLDB2 Mediates Cetuximab Resistance via Interacting With EGFR in Latent Metastasis of Colorectal Cancer	33
GDF15 Ameliorates Liver Fibrosis by Metabolic Reprogramming of Macrophages to Acquire Anti-Inflammatory Properties	33
Metabolic Regulation of Macrophages by SIRT1 Determines Activation During Cholestatic Liver Disease in Mice	33
Sonic Hedgehog and WNT Signaling Regulate a Positive Feedback Loop Between Intestinal Epithelial and Stromal Cells to Promote Epithelial Regeneration	33
Calcium Channel α2δ1 is Essential for Pancreatic Tumor-Initiating Cells through Sequential Phosphorylation of PKM2	32
Continuous Activation of C/EBPβ Transcription Factor Prevents Fibrosis Resolution After Alcohol Cessation	32
Targeting Tumor Stroma in CMS4 Colorectal Cancer: Phospholamban Takes Center Stage	32
Androgen Enhances Aflatoxin-induced Genotoxicity and Inflammation to Liver Cancer in Male Hepatitis B Patients	32
Moving Up a NOTCH: Defining the Stem Cell Niche in the Gastric Antrum	31
Myosin Light Chain 9 Mediates Graft Fibrosis After Pediatric Liver Transplantation Through TLR4/MYD88/NF-κB Signaling	31
A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach	31
Linking of Senescence to Autophagy Deficiency in Chronic Liver Disease	30
KDM6A/B Demethylases in Gut Homeostasis	30
Editorial Board	30
Contents	30
Histamine Signaling Is Essential for Tissue Macrophage Differentiation and Suppression of Bacterial Overgrowth in the Stomach	29
Editorial Board	29

Selective Elimination of NRF2-Activated Cells by Competition With Neighboring Cells in the Esophageal Epithelium	29
Hepatocytes Are Resistant to Cell Death From Canonical and Non-Canonical Inflammasome-Activated Pyroptosis	28
Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene	28
Siglec-H-/- Plasmacytoid Dendritic Cells Protect Against Acute Liver Injury by Suppressing IFN-γ/Th1 Response and Promoting IL-21+ CD4 T Cells	28
The Protective Role of DDIT4 in Helicobacter pylori-induced Gastric Metaplasia Through Metabolic Regulation of Ferroptosis	28
When Liver Slices Meet Single-cell Technology	28
Microbial Players in Primary Sclerosing Cholangitis: Current Evidence and Concepts	28
Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and Cholangiocarcinoma	27
MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by Protecting the Mucosal Epithelial Barrier	27
Acute Phase Response-driven Hepatic Niche Remodeling Promotes Fibrosis Resolution After Alcohol Cessation	27
Interplay Between Drug-Induced Liver Injury and Gut Microbiota: A Comprehensive Overview	27
Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis	26
Liver Traffic Jam: How Sinusoidal Congestion Rewires Macrophage Distribution via CXCL9	26
Congestion Enriches Intra-hepatic Macrophages Through Reverse Zonation of CXCL9 in Liver Sinusoidal Endothelial Cells	26
Scaffolding Supports the Hippo	26
Cover	26
Caffeine Limits Expansion of Apc-Deficient Clones in the Intestine by NOTUM Inhibition	26
Interferon-γ Signaling in Eosinophilic Esophagitis Affects Epithelial Barrier Function and Programmed Cell Death	25
Irritable Bowel Syndrome With Diarrhea in Pediatric Patients Is Associated With Type 2 and Type 9 T Cells in the Intestinal Mucosa	25
Microbiota-dependent Formylated Peptide Receptor (Fpr1/2) Signaling Regulates Enteric Nervous System Development and Gastrointestinal Motility in Mice	25
Increased Motility and Suppression of Ex Vivo–Expanded Regulatory T Cells Designed for Adoptive Transfer Therapy in Ulcerative Colitis	24
Purinergic Pathways in the Spinal Microglia as a Putative Target for Treatment of Chronic Abdominal Pain	24
Innate Lymphoid Cells: New Culprits of Alcohol-Associated Steatohepatitis	24
Editorial Board	24
Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity	24
A Balancing Act: GRHL3 Limits WNT Signaling to Promote Tissue Homeostasis in the Esophageal Epithelium	24
Contents	23
Wnt Signaling Silences GUCY2C Hormones in Colorectal Cancer	23
Contents	23
From Muscle to Macrophage: An Anti-inflammatory Role for the Metabolite N-lactoyl-phenylalanine in Inflammatory Bowel Disease	22
Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin–Mediated Mitophagy	22
Oxidized HMGB1 Adducts Unleash Inflammation in Alcohol-Associated Liver Disease	22
Presence of Intact Hepatitis B Virions in Exosomes	22
DNMT3B Alleviates Liver Steatosis Induced by Chronic Low-grade LPS via Inhibiting CIDEA Expression	22
A New Model of Gastric Pre-neoplasia Induced by Aberrant ADAR1-mediated Double-stranded RNA Signaling	21
ΔNP63 defines an exocrine-committed subset of murine pancreatic progenitor cells	21
Intrahepatic Exhausted Antiviral Immunity in an Immunocompetent Mouse Model of Chronic Hepatitis B	21
SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis	21
PKMζ, a Brain-specific PKCζ Isoform, is Required for Glycolysis and Myofibroblastic Activation of Hepatic Stellate Cells	21
Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-Induced Liver Injury in Aged Mice	21
CMGH: Evolving to Advance Gastroenterology and Hepatology Research	21
Genetic Variation Between Small Bowel and Colon-Predominant Crohn's Disease	20
Targeting the Cell Biology of MYO5B Loss in MVID	20
Vitamin D Receptor Activation Targets ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Hepatocytes in Cholestasic Mice	20
Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis	20
Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases	20
Cover - Blocking BRP39 Alters the Course of Liver Inflammation	20
Rethinking Immune Check Point Inhibitors Use in Liver Transplantation: Implications and Resistance	20
FGL2–MCOLN3-Autophagy Axis–Triggered Neutrophil Extracellular Traps Exacerbate Liver Injury in Fulminant Viral Hepatitis	20
Cellular Crosstalk Promotes Hepatic Progenitor Cell Proliferation and Stellate Cell Activation in 3D Co-culture	20
Genetic Ablation of C/EBPα-p300 Pathway Blocks Development of Obese Pregnancy Associated Liver Disorders in Offspring	20
Telocyte Recruitment During the Emergence of a Metaplastic Niche in the Stomach	20
Notch-Driven Cholangiocarcinogenesis Involves the Hippo Pathway Effector TAZ via METTL3-m6A-YTHDF1	20
TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models	19
Targeting USP9X–AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma	19
Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis	19
All Good Things Come to an End: 5 Years at the Helm of CMGH	19
Correction	19
Colitis-Induced Small Intestinal Hypomotility Is Dependent on Enteroendocrine Cell Loss in Mice	19
Interferon Signaling Alters Epithelial Function in Eosinophilic Esophagitis	19
Stress Granules as Molecular Echoes of Gut Inflammation	19
Actinomyces odontolyticus: From Carries to Colorectal Cancer	19
Osr1 Is a Critical Regulator of Macrophage Polarization in NASH Progression	18
Cover 1 - Mechanistic Insights Into Colonic Motor Patterns	18
Cyclin-dependent Kinase 9 as a Potential Target for Anti-TNF-resistant Inflammatory Bowel Disease	18
Reply	18
Can Psyllium Alleviate Colitis?	18
The miR-23b/27b/24-1 Cluster Inhibits Hepatic Fibrosis by Inactivating Hepatic Stellate Cells	18
Beyond Regulation of Acid Secretion: A Novel Role for Histamine in Gastric Macrophage Differentiation and Function	18
HBV X Protein Induces Degradation of UBXN7, a Novel Negative Regulator of NF-κB Signaling, to Promote HBV Replication	18
PFKFB4 Is a Metabolic Driver of HCC Progression and Chemoresistance Through ROS Mitigation	18
Pioneer Factor Foxa2 Mediates Chromatin Conformation Changes for Activation of Bile Acid Targets of FXR	18
Unraveling the Oncogenic Characteristics of the Cytolinker, Plectin, in Esophageal Squamous Cell Carcinoma	18
Wild-type APC Influences the Severity of Familial Adenomatous Polyposis	17
Cellular Interactions and Crosstalk Facilitating Biliary Fibrosis in Cholestasis	17
Correction	17
Fueling HCC Dynamics: Interplay Between Tumor Microenvironment and Tumor Initiating Cells	17
UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett’s Progression to Esophageal Adenocarcinoma	17
Rapid Research, High Impact: CMGH’s Short-Form Initiative	17
Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal Inflammation	17

Autophagy-Related Activation of Hepatic Stellate Cells Reduces Cellular miR-29a by Promoting Its Vesicular Secretion	17
Etomidate Improves Antitumor Immunity by Suppressing PD-L1 Expression in Hepatocellular Carcinoma Cells	17
On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity	17
Activation of Proneuronal Transcription Factor Ascl1 in Maternal Liver Ensures a Healthy Pregnancy	17
Oxaliplatin-Resistant Hepatocellular Carcinoma Drives Immune Evasion Through PD-L1 Up-Regulation and PMN-Singular Recruitment	17
GPR68, A Proton-sensing GPCR, Mediates Acid-induced Visceral Nociception	16
Editorial Board	16
Bone Loss in Intestinal Inflammation Disease Yields to Osteoclastogenesis Inhibition	16
Hepatic Ketogenesis Regulates Lipid Homeostasis via ACSL1-mediated Fatty Acid Partitioning	16
Editorial Board	16
Differential MYC Phosphorylation Drives the Divergent Cholangiocyte Response to Stress	16
Improving Gastric Motility in Aging Through EZH2 Inhibition and Preservation of Interstitial Cells of Cajal	16
Novel Fat Taste Receptor Agonists Curtail Progressive Weight Gain in Obese Male Mice	16
The STING That Tames Pro-inflammatory T-cells	16
Macrophage COX2 Mediates Efferocytosis, Resolution Reprogramming, and Intestinal Epithelial Repair	15
A Dual Role of HGF-ERK Signaling in IL6/HGF-induced Hepatocyte Proliferation	15
BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation	15
D-amino Acids Ameliorate Experimental Colitis and Cholangitis by Inhibiting Growth of Proteobacteria: Potential Therapeutic Role in Inflammatory Bowel Disease	15
Rethinking Fibrosis Regression in Alcohol-associated Liver Disease Through C/EBPβ Inhibition	15
Assessing Long-Term Liver Safety of Statins and PCSK9 Inhibitors Using Human Genetics	15
Intestinal Stearoyl-CoA Desaturase-1 Regulates Energy Balance via Alterations in Bile Acid Homeostasis	15
Neurotensin Regulates Proliferation and Stem Cell Function in the Small Intestine in a Nutrient-Dependent Manner	15
2’-Fucosyllactose Ameliorates Chemotherapy-Induced Intestinal Mucositis by Protecting Intestinal Epithelial Cells Against Apoptosis	15
In Vivo Determinants of Hepatitis C Virus Adaptation and Escape From Neutralizing Antibody AR5A	15
A Reflux Linked GATA Factor Fulcrum Dictates Lineage Commitment Through GPRC5B During the Esophageal Dysplastic Transition	15
Stromal Cell Regulation of Intestinal Inflammatory Fibrosis	15
Editorial Board	15
Platelets in Alcohol-Associated Liver Disease: Interaction With Neutrophils	15
Mrgprb2-dependent Mast Cell Activation Plays a Crucial Role in Acute Colitis	15
Ubiquitination of Rhomboid 5 Homolog 2 by Constitutive Photomorphogenic 1 Alleviates Hepatic Ischemia-reperfusion Injury by Regulating the Transforming Growth Factor-Β Activating Kinase 1-C-Jun N-term	15
Surgery for Crohn’s Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts	15
Alterations in Cytoskeleton and Mitochondria in the Development and Reversal of Steatosis in Human Hepatocytes	15
Liver PP2A-Cα Protects From Parenteral Nutrition-associated Hepatic Steatosis	15
Stroma New Tune: Emerging Role of PKA in Maintaining Gastric Homeostasis	15
GPAT1 Deficiency in Mice Modulates NASH Progression in a Model-Dependent Manner	15
Human Placental Extract Enhances Neonatal Intestinal Epithelial Reparative Capacity in Porcine Models	14
The Alpha-Lipoic Acid Improves Glucose Metabolism and Hyperinsulinemia in Acute Intermittent Porphyria: A Nutritional Concept for the Management of Rare Disorders	14
NFATc1 Is a Central Mediator of EGFR-Induced ARID1A Chromatin Dissociation During Acinar Cell Reprogramming	14
FACI Is a Novel CREB-H–Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity	14
DNA 6mA Demethylase ALKBH1 Orchestrates Fatty Acid Metabolism and Suppresses Diet-Induced Hepatic Steatosis	14
Dietary Selection Pressures and Their Impact on the Gut Microbiome	14
Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colitis via Governing Tuft Cell Homeostasis	14
Myeloid Cell Adhesion Molecule 1 (CADM1) Promotes Proinflammatory Signaling in Human Inflammatory Bowel Diseases	14
Phosphocreatine Rescues Intestinal Epithelial Metabolic Dysfunction Related to Creatine Kinase Loss and Is Protective in Murine Colitis	14
HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate	13
Reflux, Reprogramming, and Progenitor Fate: Reframing the Origins of Esophageal Dysplasia	13
HNRNPM Regulates HCC Tumorigenesis and Cancer Stemness: Identification of a Novel Therapeutic Target?	13
Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic Hepatitis	13
TOC	13
Innate Immune Regulation: ABHD17 Is Calling NOD2 Back From Duty	13
Colorectal 15-Lipoxygenase-1 as a Host Factor Determining the Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Colorectal Tumorigenesis in Mice	13
Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease	13
Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in Mice	13
Storage Wars: Adipose-liver Crosstalk as a Determinant of Liver Injury	13
Sphingosine Kinase 1 – A Therapeutic Opportunity for Alleviating Liver Fibrosis?	13
Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived Model	13
Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem Cells	13
Dysregulation of the Environmental Sensor Aryl Hydrocarbon Receptor Affects Differentiation of Human Colon Organoids	13
Imperatorin Alleviates Intestinal Fibrosis by Suppressing AIM2-mediated GSDMD Pyroptosis in Macrophages	12
Long Noncoding RNA uc173 is a Novel Regulator of Mitochondrial Metabolism Driving Intestinal Mucosal Growth	12
Chronic Inflammation in Ulcerative Colitis Causes Long-Term Changes in Goblet Cell Function	12
IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B	12
Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome	12
Uncertain Beginnings: Acinar and Ductal Cell Plasticity in the Development of Pancreatic Cancer	12
Escherichia fergusonii Promotes Nonobese Nonalcoholic Fatty Liver Disease by Interfering With Host Hepatic Lipid Metabolism Through Its Own msRNA 23487	12
Genome-wide CRISPR Screening Identifies NFκB and c-MET as Druggable Targets to Sensitize Lenvatinib Treatment in Hepatocellular Carcinoma	12
Hepatitis B Virus Utilizes a Retrograde Trafficking Route via the Trans-Golgi Network to Avoid Lysosomal Degradation	12
CREB Drives Acinar to Ductal Cells Reprogramming and Promotes Pancreatic Cancer Progression in Preclinical Models of Alcoholic Pancreatitis	12
The P2X7 receptor promotes intestinal fibrosis by modulating the gut microbiota and the inflammasome	12
Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell Niche	12