Molecular Therapy-Oncolytics

Article	Citations
Promoting role of pentraxin-3 in esophageal squamous cell carcinoma	133
LINC01296 promotes neuroblastoma tumorigenesis via the NCL-SOX11 regulatory complex	104
Extracellular vesicle contents as non-invasive biomarkers in ovarian malignancies	103
Azelnidipine inhibits esophageal squamous cell carcinoma proliferation in vivo and in vitro by targeting MEK1/2	69
Radiovirotherapy at twenty	64
Dynamic fine-tuning of CAR-T cell therapy	61
Thank you to our 2022 reviewers	60
hnRNPK-derived cell-penetrating peptide inhibits cancer cell survival	53
Sperm protein 17 targeting for epithelial ovarian cancer treatment in the era of modern immunoengineering	50
Lentiviral interferon: A novel method for gene therapy in bladder cancer	50
esRAGE-expressing oHSV enhances anti-tumor efficacy by inhibition of endothelial cell activation	47
Vorolanib, a novel tyrosine receptor kinase receptor inhibitor with potent preclinical anti-angiogenic and anti-tumor activity	46
MicroRNA-sensitive oncolytic measles virus for chemovirotherapy of pancreatic cancer	44
Upregulation of endogenous TRAIL-elicited apoptosis is essential for metformin-mediated antitumor activity against TNBC and NSCLC	44
Oncolytic Zika virus promotes intratumoral T cell infiltration and improves immunotherapy efficacy in glioblastoma	44
Retraction Notice to: miR-140-3p Inhibits Cutaneous Melanoma Progression by Disrupting AKT/p70S6K and JNK Pathways through ABHD2	43
Oncolytic vaccinia virus injected intravenously sensitizes pancreatic neuroendocrine tumors and metastases to immune checkpoint blockade	42
R. Daniel Beauchamp (1946–2022)	42
The tRNA-derived fragment signature in lung cancer	38
Pre-treatment with systemic agents for advanced NSCLC elicits changes in the phenotype of autologous T cell therapy products	38
PET imaging and treatment of pancreatic cancer peritoneal carcinomatosis after subcutaneous intratumoral administration of a novel oncolytic virus, CF33-hNIS-antiPDL1	38
Bacterial cancer therapy using the attenuated fowl-adapted Salmonella enterica serovar Gallinarum	38
RETRACTED: Comprehensive analysis of FKBP4/NR3C1/TMEM173 signaling pathway in triple-negative breast cancer cell and dendritic cell among tumor microenvironment	37
NEBL and AKT1 maybe new targets to eliminate the colorectal cancer cells resistance to oncolytic effect of vesicular stomatitis virus M-protein	36
Single-cell transcriptomics reveal DHX9 in mature B cell as a dynamic network biomarker before lymph node metastasis in CRC	36

Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model	35
Regulation of CD19 CAR-T cell activation based on an engineered downstream transcription factor	35
A novel TanCAR targeting IL13Rα2 and EphA2 for enhanced glioblastoma therapy	34
LRPPRC regulates metastasis and glycolysis by modulating autophagy and the ROS/HIF1-α pathway in retinoblastoma	34
Characterization and quantitation of busulfan DNA adducts in the blood of patients receiving busulfan therapy	33
Ferroptosis gene signature in cholangiocarcinoma	33
Neoadjuvant use of oncolytic herpes virus G47Δ prevents local recurrence after insufficient resection in tongue cancer models	33
Dual blockade of CD47 and CD24 signaling using a novel bispecific antibody fusion protein enhances macrophage immunotherapy	32
Next generation oncolytic viruses expressing PADI1 and TIMP2 exhibit anti-tumor activity against melanoma in nude and humanized mouse models	32
Oncogenic lncRNA BBOX1-AS1 promotes PHF8-mediated autophagy and elicits sorafenib resistance in hepatocellular carcinoma	31
Adding recombinant AAVs to the cancer therapeutics mix	31
A PD1 targeted nano-delivery system based on epigenetic alterations of T cell responses in the treatment of gastric cancer	31
Targeting carcinoembryonic antigen-expressing tumors using a novel transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1	31
The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy	30
Intratumoral delivery of a novel oncolytic adenovirus encoding human antibody against PD-1 elicits enhanced antitumor efficacy	29
Efficacy of a third-generation oncolytic herpes simplex virus in refractory soft tissue sarcoma xenograft models	28
Polycytidine tract deletion from microRNA-detargeted oncolytic Mengovirus optimizes the therapeutic index in a murine multiple myeloma model	27
Metabolic remodeling in tumor-associated macrophages contributing to antitumor activity of cryptotanshinone by regulating TRAF6-ASK1 axis	26
A novel CD34-derived hinge for rapid and efficient detection and enrichment of CAR T cells	25
Claudin18.2 bispecific T cell engager armed oncolytic virus enhances antitumor effects against pancreatic cancer	25
SNHG1 knockdown upregulates miR-376a and downregulates FOXK1/Snail axis to prevent tumor growth and metastasis in HCC	24
circBANP promotes colorectal cancer growth and metastasis via sponging let-7d-5p to modulate HMGA1/Wnt/β-catenin signaling	24
Expanding the landscape of TCR gene therapy targeting MAGE	24
Transgenic viral expression of PH-20, IL-12, and sPD1-Fc enhances immune cell infiltration and anti-tumor efficacy of an oncolytic virus	23
DNA-methylation-induced silencing of DIO3OS drives non-small cell lung cancer progression via activating hnRNPK-MYC-CDC25A axis	23
Nanobody-based retargeting of an oncolytic herpesvirus for eliminating CXCR4+ GBM cells: A proof of principle	23
Improved lentiviral vector titers from a multi-gene knockout packaging line	23
Spatiotemporal analysis of induced neural stem cell therapy to overcome advanced glioblastoma recurrence	23
Deletion of immunomodulatory genes as a novel approach to oncolytic vaccinia virus development	23
Icaritin inhibits PLK1 to activate DNA damage response in NK/T cell lymphoma and increases sensitivity to GELOX regime	22
Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma	22
Lazertinib improves the efficacy of chemotherapeutic drugs in ABCB1 or ABCG2 overexpression cancer cells in vitro, in vivo, and ex vivo	22
Nucleic acids and proteins carried by exosomes of different origins as potential biomarkers for gynecologic cancers	22
TRIM22 orchestrates the proliferation of GBMs and the benefits of TMZ by coordinating the modification and degradation of RIG-I	22
Regulatory role and mechanism of m6A RNA modification in human metabolic diseases	22
The next wave of cellular immunotherapies in pancreatic cancer	22
Novel roles of METTL1/WDR4 in tumor via m7G methylation	22
PBX3-activated DLG1-AS1 can promote the proliferation, invasion, and migration of TNBC cells by sponging miR-16-5p	21
Oncolytic virotherapy with intratumoral injection of vaccinia virus TG6002 and 5-fluorocytosine administration in dogs with malignant tumors	21
Systematic profiling of ferroptosis gene signatures predicts prognostic factors in esophageal squamous cell carcinoma	21
Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seq	21
Combination of a STAT3 inhibitor with anti-PD-1 immunotherapy is an effective treatment regimen for a vemurafenib-resistant melanoma	21
Synthetic mRNA-based gene therapy for glioblastoma: TRAIL-mRNA synergistically enhances PTEN-mRNA-based therapy	21
Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis	21
Efficacy and safety of a third-generation oncolytic herpes virus G47Δ in models of human esophageal carcinoma	20
PTEN potentiation of oncolytic HSV therapy for glioblastoma	20
The pivotal regulatory factor circBRWD1 inhibits arsenic exposure-induced lung cancer occurrence by binding mRNA and regulating its stability	20
Reinvigoration of innate and adaptive immunity via therapeutic cellular vaccine for patients with AML	20
LINC00461 facilitates HNSCC development and reduces chemosensitivity by impairing miR-195-mediated inhibition of HOXA10	20
Development of a 5-FU modified miR-129 mimic as a therapeutic for non-small cell lung cancer	20

Palmitoylated antigens for the induction of anti-tumor CD8+ T cells and enhanced tumor recognition	19
Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors	19
Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model	19
RHAMMB-mediated bifunctional nanotherapy targeting Bcl-xL and mitochondria for pancreatic neuroendocrine tumor treatment	19
Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation	19
Treatment of glioblastoma with current oHSV variants reveals differences in efficacy and immune cell recruitment	19
lncRNA MIR503HG inhibits cell proliferation and promotes apoptosis in TNBC cells via the miR-224-5p/HOXA9 axis	19
Enhanced tumor targeting and timely viral release of mesenchymal stem cells/oncolytic virus complex due to GRP78 and inducible E1B55K expressions greatly increase the antitumor effect of systemic trea	19
A systematic analysis on the clinical safety and efficacy of onco-virotherapy	19
Interleukin-6-controlled, mesenchymal stem cell-based sodium/iodide symporter gene therapy improves survival of glioblastoma-bearing mice	19
Narciclasine targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells	19
Metformin preferentially enhances the radio-sensitivity of cancer stem-like cells with highly mitochondrial respiration ability in HMPOS	18
Therapeutic effects of TM4SF5-targeting chimeric and humanized monoclonal antibodies in hepatocellular and colon cancer models	18
IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma	18
Oncolytic virotherapy targeting the IL15 pathway	18
The quest for effective immunotherapies against malignant peripheral nerve sheath tumors: Is there hope?	18
Infection of non-cancer cells: A barrier or support for oncolytic virotherapy?	18
Diversity in responses to oncolytic Lassa-vesicular stomatitis virus in patient-derived glioblastoma cells	18
MicroRNA-detargeting proves more effective than leader gene deletion for improving safety of oncolytic Mengovirus in a nude mouse model	18
Chandipura virus induces cell death in cancer cell lines of human origin and promotes tumor regression in vivo	18
Modulation of p53 expression in cancer-associated fibroblasts prevents peritoneal metastasis of gastric cancer	17
Thank you to our 2021 reviewers	17
Gene-edited and CAR-NK cells: Opportunities and challenges with engineering of NK cells for immunotherapy	17
Treatment with the PPARα agonist fenofibrate improves the efficacy of CD8+ T cell therapy for melanoma	17
Oncolytic adenovirus for treatment of malignant ascites	17
Quantitative proteomics characterization of cancer biomarkers and treatment	17
Zika virus cleaves GSDMD to disseminate prognosticable and controllable oncolysis in a human glioblastoma cell model	17
A novel anti-B7-H3 chimeric antigen receptor from a single-chain antibody library for immunotherapy of solid cancers	17
CD133 mRNA-transfected dendritic cells induce coordinated cytotoxic and helper T cell responses against breast cancer stem cells	16
miR-146a: Overcoming coldness in ovarian cancer	16
Therapeutically targeting oncogenic CRCs facilitates induced differentiation of NB by RA and the BET bromodomain inhibitor	16
HKI-272 contributes to gemcitabine-mediated anti-proliferative and anti-metastatic effects through EGFR suppression in gallbladder cancer	16
Seneca Valley virus replicons are packaged in trans and have the capacity to overcome the limitations of viral transgene expression	16
A New Tool for CRISPR-Cas13a-Based Cancer Gene Therapy	15
Ubiquitin-related molecular classification and risk stratification of hepatocellular carcinoma	15
A host non-coding RNA, nc886, plays a pro-viral role by promoting virus trafficking to the nucleus	15
New advances in cancer therapy targeting TGF-β signaling pathways	15
β2-Adrenergic receptor agonist enhances the bystander effect of HSV-TK/GCV gene therapy in glioblastoma multiforme via upregulation of connexin 43 expression	15
Secretion of bispecific protein of anti-PD-1 fused with TGF-β trap enhances antitumor efficacy of CAR-T cell therapy	14
miR-15a and miR-15b modulate natural killer and CD8+T-cell activation and anti-tumor immune response by targeting PD-L1 in neuroblastoma	14
DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D	14
miR-301 regulates the SIRT1/SOX2 pathway via CPEB1 in the breast cancer progression	14
Polymer stealthing and mucin-1 retargeting for enhanced pharmacokinetics of an oncolytic vaccinia virus	14
Targeting receptor tyrosine kinases in ovarian cancer: Genomic dysregulation, clinical evaluation of inhibitors, and potential for combinatorial therapies	14
Reprogramming the tumor microenvironment leverages CD8+ T cell responses to a shared tumor/self antigen in ovarian cancer	14
Novel two-chain structure utilizing KIRS2/DAP12 domain improves the safety and efficacy of CAR-T cells in adults with r/r B-ALL	14
Knockdown of SENP1 inhibits HIF-1α SUMOylation and suppresses oncogenic CCNE1 in Wilms tumor	14
Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma	14
Nuclear export protein CSE1L interacts with P65 and promotes NSCLC growth via NF-κB/MAPK pathway	14
ScRNA-seq and bulk RNA-seq reveal the characteristics of ferroptosis and establish a risk signature in cholangiocarcinoma	14
The miR-23a/27a/24-2 cluster promotes postoperative progression of early-stage non-small cell lung cancer	13
Carboranes as unique pharmacophores in antitumor medicinal chemistry	13
Vaccinia virus and peptide-receptor radiotherapy synergize to improve treatment of peritoneal carcinomatosis	13
m6A methyltransferase METTL3-mediated lncRNA FOXD2-AS1 promotes the tumorigenesis of cervical cancer	13
Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory	13
Oncolytic viruses: Narcissistic or altruistic arsonists?	13
Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus	13
Retraction Notice to: Exosomes Carrying MicroRNA-155 Target Forkhead Box O3 of Endothelial Cells and Promote Angiogenesis in Gastric Cancer	13
Induction of cell death in ovarian cancer cells by doxorubicin and oncolytic vaccinia virus is associated with CREB3L1 activation	13
Cholesterol-enriched membrane micro-domain deficiency induces doxorubicin resistance via promoting autophagy in breast cancer	13
Non-coding RNAs and glioma: Focus on cancer stem cells	12
DNA-damaging cancer cells to improve virotherapy	12
Trap and ambush therapy using sequential primary and tumor escape-selective oncolytic viruses	12
Redirecting anti-Vaccinia virus T cell immunity for cancer treatment by AAV-mediated delivery of the VV B8R gene	12
The role of long non-coding RNAs in the pathogenesis of head and neck squamous cell carcinoma	12
PROTACs in gastrointestinal cancers	12
Noncoding RNA-mediated macrophage and cancer cell crosstalk in hepatocellular carcinoma	12
MicroRNA-499 serves as a sensitizer for lung cancer cells to radiotherapy by inhibition of CK2α-mediated phosphorylation of p65	12
Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells	12
Novel insights into circular RNA regulation in arsenic-exposure-induced lung cancer	12
CRISPR-Cas knockout of miR21 reduces glioma growth	12
Exosomal and intracellular miR-320b promotes lymphatic metastasis in esophageal squamous cell carcinoma	12
miR-519d-3p suppresses tumorigenicity and metastasis by inhibiting Bcl-w and HIF-1α in NSCLC	12
Circular RNA circRAB31 acts as a miR-885-5p sponge to suppress gastric cancer progression via the PTEN/PI3K/AKT pathway	12
Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunities	11
Attack of the clones: An NK cell origins story	11
Nucleic acids and proteins carried by exosomes of different origins as potential biomarkers for gynecologic cancers	11
Improved oncolytic activity of a reovirus mutant that displays enhanced virus spread due to reduced cell attachment	11
Multiple targeted self-emulsifying compound RGO reveals obvious anti-tumor potential in hepatocellular carcinoma	11
Neoadjuvant systemic oncolytic vesicular stomatitis virus is safe and may enhance long-term survivorship in dogs with naturally occurring osteosarcoma	11

Cancer stem/progenitor signatures refine the classification of clear cell renal cell carcinoma with stratified prognosis and decreased immunotherapy efficacy	11
lncRNA RP11-147L13.8 suppresses metastasis and chemo-resistance by modulating the phosphorylation of c-Jun protein in GBC	11
Ligand-based, piggyBac-engineered CAR-T cells targeting EGFR are safe and effective against non-small cell lung cancers	11
Circular RNA circLAMA3 inhibits the proliferation of bladder cancer by directly binding an mRNA	11
IFNAR blockade synergizes with oncolytic VSV to prevent virus-mediated PD-L1 expression and promote antitumor T cell activity	11
Thank you to our 2023 reviewers	11
Physiological lentiviral vectors for the generation of improved CAR-T cells	11
Potent anti-tumor effects of receptor-retargeted syncytial oncolytic herpes simplex virus	11
Beyond ENO1, emerging roles and targeting strategies of other enolases in cancers	10
Targeting the lactic acid metabolic pathway for antitumor therapy	10
Natural killer cells and immune-checkpoint inhibitor therapy: Current knowledge and new challenges	10
Targeting EGFR sensitizes 5-Fu-resistant colon cancer cells through modification of the lncRNA-FGD5-AS1-miR-330-3p-Hexokinase 2 axis	10
Addition of BTK inhibitor orelabrutinib to rituximab improved anti-tumor effects in B cell lymphoma	10
TTN-AS1 accelerates the growth and migration of nasopharyngeal carcinoma cells via targeting miR-876-5p/NETO2	10
Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity	10
Oncolytic virus-mediated p53 overexpression promotes immunogenic cell death and efficacy of PD-1 blockade in pancreatic cancer	10
SEC coupled with in-line multiple detectors for the characterization of an oncolytic Coxsackievirus	10
Introducing a new reporter gene, membrane-anchored Cypridina luciferase, for multiplex bioluminescence imaging	10
Remission of liquid tumors and SARS-CoV-2 infection: A literature review	10
Defueling the cancer: ATP synthase as an emerging target in cancer therapy	10
Nanobody-derived bispecific CAR-T cell therapy enhances the anti-tumor efficacy of T cell lymphoma treatment	10
Efficacy of coxsackievirus A21 against drug-resistant neoplastic B cells	10
Endogenous H3.3K27M derived peptide restricted to HLA-A∗02:01 is insufficient for immune-targeting in diffuse midline glioma	10
Enhancing the effectiveness of γδ T cells by mRNA transfection of chimeric antigen receptors or bispecific T cell engagers	10
CCL18 promotes breast cancer progression by exosomal miR-760 activation of ARF6/Src/PI3K/Akt pathway	10
Fluorescent imaging for cancer therapy and cancer gene therapy	10
Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis	10
Cardamonin suppresses pro-tumor function of macrophages by decreasing M2 polarization on ovarian cancer cells via mTOR inhibition	9
Association of IDH mutation and 1p19q co-deletion with tumor immune microenvironment in lower-grade glioma	9
Controlled release of enhanced cross-hybrid IgGA Fc PD-L1 inhibitors using oncolytic adenoviruses	9
Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations	9
Boosting antitumor response with PSMA-targeted immunomodulatory VLPs, harboring costimulatory TNFSF ligands and GM-CSF cytokine	9
Oncolytic Urabe mumps virus: A promising virotherapy for triple-negative breast cancer	9
An oncolytic virus as a promising candidate for the treatment of radioresistant oral squamous cell carcinoma	9
Sodium iodide symporter-targeted gene therapy in glioblastoma	9
Inhibition of MEK-ERK pathway enhances oncolytic vaccinia virus replication in doxorubicin-resistant ovarian cancer	9
Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer	9
Development of a low-seroprevalence, αvβ6 integrin-selective virotherapy based on human adenovirus type 10	9
Targeting SOS1 overcomes imatinib resistance with BCR-ABL independence through uptake transporter SLC22A4 in CML	9
Development of a seven-gene tumor immune microenvironment prognostic signature for high-risk grade III endometrial cancer	9
JNTX-101, a novel albumin-encapsulated gemcitabine prodrug, is efficacious and operates via caveolin-1-mediated endocytosis	9
Molecular Therapy Oncology: What’s in a name?	9
R-2HG downregulates ERα to inhibit cholangiocarcinoma via the FTO/m6A-methylated ERα/miR16-5p/YAP1 signal pathway	9
Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma	9
An oral cancer vaccine using a Bifidobacterium vector suppresses tumor growth in a syngeneic mouse bladder cancer model	9
Enhanced genomic stability of new miRNA-regulated oncolytic coxsackievirus B3	9
Integrated analysis reveals the molecular features of fibrosis in triple-negative breast cancer	9
Stabilization of DEPTOR sensitizes hypopharyngeal cancer to radiotherapy via targeting degradation	9
Comprehensive analysis of lncRNAs as biomarkers for diagnosis, prognosis, and treatment response in clear cell renal cell carcinoma	9