Molecular Therapy-Oncolytics

Article	Citations
Promoting role of pentraxin-3 in esophageal squamous cell carcinoma	164
Targeting carcinoembryonic antigen-expressing tumors using a novel transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1	122
esRAGE-expressing oHSV enhances anti-tumor efficacy by inhibition of endothelial cell activation	113
Efficacy of a third-generation oncolytic herpes simplex virus in refractory soft tissue sarcoma xenograft models	83
Sperm protein 17 targeting for epithelial ovarian cancer treatment in the era of modern immunoengineering	67
Ferroptosis gene signature in cholangiocarcinoma	64
The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy	60
Spatiotemporal analysis of induced neural stem cell therapy to overcome advanced glioblastoma recurrence	53
Deletion of immunomodulatory genes as a novel approach to oncolytic vaccinia virus development	53
Lazertinib improves the efficacy of chemotherapeutic drugs in ABCB1 or ABCG2 overexpression cancer cells in vitro, in vivo, and ex vivo	53
Metabolic remodeling in tumor-associated macrophages contributing to antitumor activity of cryptotanshinone by regulating TRAF6-ASK1 axis	51
Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model	50
A New Tool for CRISPR-Cas13a-Based Cancer Gene Therapy	49
Reinvigoration of innate and adaptive immunity via therapeutic cellular vaccine for patients with AML	47
Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seq	45
A novel anti-B7-H3 chimeric antigen receptor from a single-chain antibody library for immunotherapy of solid cancers	44
Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma	43
Synthetic mRNA-based gene therapy for glioblastoma: TRAIL-mRNA synergistically enhances PTEN-mRNA-based therapy	43
Cancer stem/progenitor signatures refine the classification of clear cell renal cell carcinoma with stratified prognosis and decreased immunotherapy efficacy	42
lncRNA RP11-147L13.8 suppresses metastasis and chemo-resistance by modulating the phosphorylation of c-Jun protein in GBC	42
The miR-23a/27a/24-2 cluster promotes postoperative progression of early-stage non-small cell lung cancer	40
PROTACs in gastrointestinal cancers	39
miR-519d-3p suppresses tumorigenicity and metastasis by inhibiting Bcl-w and HIF-1α in NSCLC	39
Circular RNA circLAMA3 inhibits the proliferation of bladder cancer by directly binding an mRNA	38
Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity	38

Knockdown of LRRN1 inhibits malignant phenotypes through the regulation of HIF-1α/Notch pathway in pancreatic ductal adenocarcinoma	37
CAFs/tumor cells co-targeting DNA vaccine in combination with low-dose gemcitabine for the treatment of Panc02 murine pancreatic cancer	36
miR-1207-5p suppresses laryngeal squamous cell carcinoma progression by downregulating SKA3 and inhibiting epithelial-mesenchymal transition	35
Advances and new frontiers for immunotherapy in colorectal cancer: Setting the stage for neoadjuvant success?	34
Oncolytic virotherapy with chimeric VSV-NDV synergistically supports RIG-I-dependent checkpoint inhibitor immunotherapy	34
Amplification of the CXCR3/CXCL9 axis via intratumoral electroporation of plasmid CXCL9 synergizes with plasmid IL-12 therapy to elicit robust anti-tumor immunity	34
Potential for reversing miR-634-mediated cytoprotective processes to improve efficacy of chemotherapy against oral squamous cell carcinoma	33
In vivo DNA-launched bispecific T cell engager targeting IL-13Rα2 controls tumor growth in an animal model of glioblastoma multiforme	33
Replication-incompetent influenza A viruses armed with IFN-γ effectively mediate immune modulation and tumor destruction in mice harboring lung cancer	32
Metformin inhibits gastric cancer cell proliferation by regulation of a novel Loc100506691-CHAC1 axis	32
Oncolytic adenovirus-mediated expression of decorin facilitates CAIX-targeting CAR-T therapy against renal cell carcinoma	31
AAMP promotes colorectal cancer metastasis by suppressing SMURF2-mediated ubiquitination and degradation of RhoA	30
Intraperitoneal oncolytic virotherapy for patients with malignant ascites: Characterization of clinical efficacy and antitumor immune response	30
Bispecific CD33/CD123 targeted chimeric antigen receptor T cells for the treatment of acute myeloid leukemia	29
MMP25-AS1/hsa-miR-10a-5p/SERPINE1 axis as a novel prognostic biomarker associated with immune cell infiltration in KIRC	28
Durable remission related to CAR-T persistence in R/R B-ALL and long-term persistence potential of prime CAR-T	27
A library of cancer testis specific T cell receptors for T cell receptor gene therapy	27
Current development in adenoviral vectors for cancer immunotherapy	27
CircRHBDD1 augments metabolic rewiring and restricts immunotherapy efficacy via m6A modification in hepatocellular carcinoma	27
Pan-cancer analysis reveals distinct clinical, genomic, and immunological features of the LILRB immune checkpoint family in acute myeloid leukemia	26
The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges	26
Cannabinoid receptors promote chronic intermittent hypoxia-induced breast cancer metastasis via IGF-1R/AKT/GSK-3β	26
Radiovirotherapy at twenty	25
Pre-treatment with systemic agents for advanced NSCLC elicits changes in the phenotype of autologous T cell therapy products	24
Oncolytic vaccinia virus injected intravenously sensitizes pancreatic neuroendocrine tumors and metastases to immune checkpoint blockade	24
A PD1 targeted nano-delivery system based on epigenetic alterations of T cell responses in the treatment of gastric cancer	24
LINC01296 promotes neuroblastoma tumorigenesis via the NCL-SOX11 regulatory complex	24
RETRACTED: Comprehensive analysis of FKBP4/NR3C1/TMEM173 signaling pathway in triple-negative breast cancer cell and dendritic cell among tumor microenvironment	24
Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis	24
Adding recombinant AAVs to the cancer therapeutics mix	24
Bacterial cancer therapy using the attenuated fowl-adapted Salmonella enterica serovar Gallinarum	23
Oncolytic Zika virus promotes intratumoral T cell infiltration and improves immunotherapy efficacy in glioblastoma	23
Diversity in responses to oncolytic Lassa-vesicular stomatitis virus in patient-derived glioblastoma cells	23
Thank you to our 2021 reviewers	23
Oncolytic adenovirus for treatment of malignant ascites	23
Nucleic acids and proteins carried by exosomes of different origins as potential biomarkers for gynecologic cancers	23
Interleukin-6-controlled, mesenchymal stem cell-based sodium/iodide symporter gene therapy improves survival of glioblastoma-bearing mice	23
Infection of non-cancer cells: A barrier or support for oncolytic virotherapy?	23
The quest for effective immunotherapies against malignant peripheral nerve sheath tumors: Is there hope?	22
DNA-damaging cancer cells to improve virotherapy	22
An oral cancer vaccine using a Bifidobacterium vector suppresses tumor growth in a syngeneic mouse bladder cancer model	22
Thank you to our 2023 reviewers	22
ScRNA-seq and bulk RNA-seq reveal the characteristics of ferroptosis and establish a risk signature in cholangiocarcinoma	22
Efficacy of coxsackievirus A21 against drug-resistant neoplastic B cells	22
TTN-AS1 accelerates the growth and migration of nasopharyngeal carcinoma cells via targeting miR-876-5p/NETO2	22
Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation	22
Seneca Valley virus replicons are packaged in trans and have the capacity to overcome the limitations of viral transgene expression	22
Vaccinia virus and peptide-receptor radiotherapy synergize to improve treatment of peritoneal carcinomatosis	22
Enhancing the effectiveness of γδ T cells by mRNA transfection of chimeric antigen receptors or bispecific T cell engagers	21
Targeting EGFR sensitizes 5-Fu-resistant colon cancer cells through modification of the lncRNA-FGD5-AS1-miR-330-3p-Hexokinase 2 axis	21

Redirecting anti-Vaccinia virus T cell immunity for cancer treatment by AAV-mediated delivery of the VV B8R gene	21
Exosomal and intracellular miR-320b promotes lymphatic metastasis in esophageal squamous cell carcinoma	21
Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory	20
Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunities	20
Sodium iodide symporter-targeted gene therapy in glioblastoma	20
An epitope encoded by uORF of RNF10 elicits a therapeutic anti-tumor immune response	20
A new strategy for treating colorectal cancer: Regulating the influence of intestinal flora and oncolytic virus on interferon	20
Optimized NGFR-derived hinges for rapid and efficient enrichment and detection of CAR T cells in vitro and in vivo	20
Non-coding RNAs and glioma: Focus on cancer stem cells	20
Multivalent in vivo delivery of DNA-encoded bispecific T cell engagers effectively controls heterogeneous GBM tumors and mitigates immune escape	20
Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas	20
A cross-reactive pH-dependent EGFR antibody with improved tumor selectivity and penetration obtained by structure-guided engineering	19
Therapeutic potential of gene therapy for gastrointestinal diseases: Advancements and future perspectives	19
Systematic review of the immunological landscape of Wilms tumors	19
Activation of interferon regulatory factor 3 by replication-competent vaccinia viruses improves antitumor efficacy mediated by T cell responses	19
Comprehensive landscape of tRNA-derived fragments in lung cancer	19
Highly efficient PD-1-targeted CRISPR-Cas9 for tumor-infiltrating lymphocyte-based adoptive T cell therapy	19
Advancing together and moving forward: Combination gene and cellular immunotherapies	19
A novel PD-L1-targeted shark VNAR single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer	19
Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells	19
Gaining insights into virotherapy with canine models	19
Exploring the potential of eRNAs in cancer immunotherapy	19
DNA immunotherapy targeting BARF1 induces potent anti-tumor responses against Epstein-Barr-virus-associated carcinomas	19
Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution	19
Purple sweet potato delphinidin-3-rutin represses glioma proliferation by inducing miR-20b-5p/Atg7-dependent cytostatic autophagy	19
Tagmentation-based analysis reveals the clonal behavior of CAR-T cells in association with lentivector integration sites	18
Genomic instability in lower-grade glioma: Prediction of prognosis based on lncRNA and immune infiltration	18
Cross-study safety analysis of risk factors in CAR T cell clinical trials: An FDA database pilot project	18
The complex relationship between integrins and oncolytic herpes Simplex Virus 1 in high-grade glioma therapeutics	18
Targeting mesothelin in cancer	18
Development of STEAP1 targeting chimeric antigen receptor for adoptive cell therapy against cancer	18
Immunotherapy by mesenchymal stromal cell delivery of oncolytic viruses for treating metastatic tumors	18
Allogeneic tumor cell-derived extracellular vesicles stimulate CD8 T cell response in colorectal cancer	18
A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase	18
Landscape and perspectives of macrophage -targeted cancer therapy in clinical trials	18
Advancements in CRISPR screens for the development of cancer immunotherapy strategies	18
AXL receptor is required for Zika virus strain MR-766 infection in human glioblastoma cell lines	17
A cancer cell membrane coated, doxorubicin and microRNA co-encapsulated nanoplatform for colorectal cancer theranostics	17
Non-coding RNAs and glioblastoma: Insight into their roles in metastasis	17
Retraction Notice to: miR-140-3p Inhibits Cutaneous Melanoma Progression by Disrupting AKT/p70S6K and JNK Pathways through ABHD2	16
Icaritin inhibits PLK1 to activate DNA damage response in NK/T cell lymphoma and increases sensitivity to GELOX regime	16
Combined BRM270 and endostatin inhibit relapse of NSCLC while suppressing lung cancer stem cell proliferation induced by endostatin	16
Expanding the landscape of TCR gene therapy targeting MAGE	16
Improved lentiviral vector titers from a multi-gene knockout packaging line	16
NEBL and AKT1 maybe new targets to eliminate the colorectal cancer cells resistance to oncolytic effect of vesicular stomatitis virus M-protein	16
miR-146a inhibits ovarian tumor growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8+ T cell infiltration	16
Claudin18.2 bispecific T cell engager armed oncolytic virus enhances antitumor effects against pancreatic cancer	16
Novel roles of METTL1/WDR4 in tumor via m7G methylation	15
Metformin preferentially enhances the radio-sensitivity of cancer stem-like cells with highly mitochondrial respiration ability in HMPOS	15
CD133 mRNA-transfected dendritic cells induce coordinated cytotoxic and helper T cell responses against breast cancer stem cells	15
Oncolytic viruses: Narcissistic or altruistic arsonists?	15
The next wave of cellular immunotherapies in pancreatic cancer	15
PBX3-activated DLG1-AS1 can promote the proliferation, invasion, and migration of TNBC cells by sponging miR-16-5p	15
PTEN potentiation of oncolytic HSV therapy for glioblastoma	15
Combination of a STAT3 inhibitor with anti-PD-1 immunotherapy is an effective treatment regimen for a vemurafenib-resistant melanoma	15
Extracellular vesicle contents as non-invasive biomarkers in ovarian malignancies	15
Novel two-chain structure utilizing KIRS2/DAP12 domain improves the safety and efficacy of CAR-T cells in adults with r/r B-ALL	15
Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus	15
Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis	14
CRISPR-Cas knockout of miR21 reduces glioma growth	14
Cardamonin suppresses pro-tumor function of macrophages by decreasing M2 polarization on ovarian cancer cells via mTOR inhibition	14
Attack of the clones: An NK cell origins story	14
Potent anti-tumor effects of receptor-retargeted syncytial oncolytic herpes simplex virus	14
Fluorescent imaging for cancer therapy and cancer gene therapy	14
Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells	14
Carboranes as unique pharmacophores in antitumor medicinal chemistry	14
Stabilization of DEPTOR sensitizes hypopharyngeal cancer to radiotherapy via targeting degradation	13
E26 transformation-specific variant 4 as a tumor promotor in human cancers through specific molecular mechanisms	13
A gene expression-based immune content predictor for survival and postoperative radiotherapy response in head and neck cancer	13
lncRNA DSCR8 mediates miR-137/Cdc42 to regulate gastric cancer cell proliferation, invasion, and cell cycle as a competitive endogenous RNA	13
Development of a bicistronic anti-CD19/CD20 CAR construct including abrogation of unexpected nucleic acid sequence deletions	13
LncRNA CBR3-AS1 promotes osteosarcoma progression through the network of miR-140-5p/DDX54-NUCKS1-mTOR signaling pathway	13
Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-β-catenin-driven M2 macrophage	13
An effective therapeutic regime for treatment of glioma using oncolytic vaccinia virus expressing IL-21 in combination with immune checkpoint inhibition	13
A library of cancer testis specific T cell receptors for T cell receptor gene therapy	13
Development of a low-seroprevalence, αvβ6 integrin-selective virotherapy based on human adenovirus type 10	13
Prognostic value of metabolic signature on 18F-FDG uptake in breast cancer patients after radiotherapy	13
Oncolytic adenovirus inhibits malignant ascites of advanced ovarian cancer by reprogramming the ascitic immune microenvironment	13
Development and comparison of 68Ga/18F/64Cu-labeled nanobody tracers probing Claudin18.2	12
Dual targeting of EZH1 and EZH2 for the treatment of malignant rhabdoid tumors	12

Combination microRNA-based cellular reprogramming with paclitaxel enhances therapeutic efficacy in a relapsed and multidrug-resistant model of epithelial ovarian cancer	12
PI3K-activated MSC proteomes inhibit mammary tumors via Hsp90ab1 and Myh9	12
Silencing ZIC2 abrogates tumorigenesis and anoikis resistance of non-small cell lung cancer cells by inhibiting Src/FAK signaling	12
CD3 engagement as a new strategy for allogeneic “off-the-shelf” T cell therapy	12
Immune priming using DC- and T cell-targeting gene therapy sensitizes both treated and distant B16 tumors to checkpoint inhibition	12
Overcoming resistance of stroma-rich pancreatic cancer with focal adhesion kinase inhibitor combined with G47Δ and immune checkpoint inhibitors	12
lncRNA SNHG26 promoted the growth, metastasis, and cisplatin resistance of tongue squamous cell carcinoma through PGK1/Akt/mTOR signal pathway	12
NAD+ depletion enhances reovirus-induced oncolysis in multiple myeloma	12
A novel fusion protein scaffold 18/12/TxM activates the IL-12, IL-15, and IL-18 receptors to induce human memory-like natural killer cells	12
Oncolytic herpes virus G47Δ injected into tongue cancer swiftly traffics in lymphatics and suppresses metastasis	12
Dual-targeting vaccine of FGL1/CAIX exhibits potent anti-tumor activity by activating DC-mediated multi-functional CD8 T cell immunity	12
CD47-targeted optical molecular imaging and near-infrared photoimmunotherapy in the detection and treatment of bladder cancer	12
Neoadjuvant use of oncolytic herpes virus G47Δ prevents local recurrence after insufficient resection in tongue cancer models	11
LRPPRC regulates metastasis and glycolysis by modulating autophagy and the ROS/HIF1-α pathway in retinoblastoma	11
Progress and application of circulating tumor cells in non-small cell lung cancer	11
Annexin A8 regulated by lncRNA-TUG1/miR-140-3p axis promotes bladder cancer progression and metastasis	11
Breast cancer tumor microenvironment affects Treg/IL-17-producing Treg/Th17 cell axis: Molecular and therapeutic perspectives	11
The tRNA-derived fragment signature in lung cancer	11
CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities	11
Long non-coding RNAs and circular RNAs in tumor angiogenesis: From mechanisms to clinical significance	11
Anti-tumor immunity enhancement by photodynamic therapy with talaporfin sodium and anti-programmed death 1 antibody	11
Oncogenic lncRNA BBOX1-AS1 promotes PHF8-mediated autophagy and elicits sorafenib resistance in hepatocellular carcinoma	11
Dynamic fine-tuning of CAR-T cell therapy	11
PET imaging and treatment of pancreatic cancer peritoneal carcinomatosis after subcutaneous intratumoral administration of a novel oncolytic virus, CF33-hNIS-antiPDL1	11
Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model	11
CXCR5 guides migration and tumor eradication of anti-EGFR chimeric antigen receptor T cells	11