OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Therapy-Oncolytics is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect	86
Targeting YTHDF1 effectively re-sensitizes cisplatin-resistant colon cancer cells by modulating GLS-mediated glutamine metabolism	70
B7-H3-Targeted CAR-T Cells Exhibit Potent Antitumor Effects on Hematologic and Solid Tumors	68
Efficacy and Safety of CD28- or 4-1BB-Based CD19 CAR-T Cells in B Cell Acute Lymphoblastic Leukemia	65
Molecular profiles of small cell lung cancer subtypes: Therapeutic implications	62
CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities	60
Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer	60
Rapidly Switchable Universal CAR-T Cells for Treatment of CD123-Positive Leukemia	58
M2 macrophage-derived exosomal microRNA-155-5p promotes the immune escape of colon cancer by downregulating ZC3H12B	56
Tumor-Secreted Exosomal lncRNA POU3F3 Promotes Cisplatin Resistance in ESCC by Inducing Fibroblast Differentiation into CAFs	53
Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy	50
Carboranes as unique pharmacophores in antitumor medicinal chemistry	49
Fascin actin-bundling protein 1 in human cancer: Promising biomarker or therapeutic target?	47
Analysis of Lung Adenocarcinoma Subtypes Based on Immune Signatures Identifies Clinical Implications for Cancer Therapy	46
ENO1 and Cancer	46
Efficacy of a Third-Generation Oncolytic Herpes Virus G47Δ in Advanced Stage Models of Human Gastric Cancer	46
Systematic profiling of ferroptosis gene signatures predicts prognostic factors in esophageal squamous cell carcinoma	44
Single-cell RNA sequencing in cancer: Applications, advances, and emerging challenges	43
Engineered CAR-T cells targeting TAG-72 and CD47 in ovarian cancer	40
Engineering Chimeric Antigen Receptor T Cells against Immune Checkpoint Inhibitors PD-1/PD-L1 for Treating Pancreatic Cancer	40
Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways	39
Tumor microenvironment and immune-related therapies of head and neck squamous cell carcinoma	39
CircRHBDD1 augments metabolic rewiring and restricts immunotherapy efficacy via m6A modification in hepatocellular carcinoma	39
Route of 41BB/41BBL Costimulation Determines Effector Function of B7-H3-CAR.CD28ζ T Cells	38
Tumor immune microenvironment-based classifications of bladder cancer for enhancing the response rate of immunotherapy	38

CAR-T Cells Targeting Epstein-Barr Virus gp350 Validated in a Humanized Mouse Model of EBV Infection and Lymphoproliferative Disease	37
Valeric Acid Suppresses Liver Cancer Development by Acting as a Novel HDAC Inhibitor	37
Chimeric Antigen Receptor T Cell Therapy Targeting ICAM-1 in Gastric Cancer	36
Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation	36
Viral Delivery of CAR Targets to Solid Tumors Enables Effective Cell Therapy	36
Mesenchymal Stem Cell-Secreted Exosome Promotes Chemoresistance in Breast Cancer via Enhancing miR-21-5p-Mediated S100A6 Expression	36
The next wave of cellular immunotherapies in pancreatic cancer	35
The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy	35
Prognostic Implication of a Metabolism-Associated Gene Signature in Lung Adenocarcinoma	35
Secretion of bispecific protein of anti-PD-1 fused with TGF-β trap enhances antitumor efficacy of CAR-T cell therapy	34
Comprehensive Analysis of the Expressionand Prognosis for TDO2 in Breast Cancer	34
Novel roles of METTL1/WDR4 in tumor via m7G methylation	34
Chromosome Abnormalities: New Insights into Their Clinical Significance in Cancer	34
Prognostic and therapeutic TILs of cervical cancer—Current advances and future perspectives	33
Non-coding RNAs and glioblastoma: Insight into their roles in metastasis	33
Angiogenesis-related non-coding RNAs and gastrointestinal cancer	33
Inhibition of Autophagy Amplifies Baicalein-Induced Apoptosis in Human Colorectal Cancer	32
Exosomal and intracellular miR-320b promotes lymphatic metastasis in esophageal squamous cell carcinoma	32
The m6A-Related mRNA Signature Predicts the Prognosis of Pancreatic Cancer Patients	32
Comparison of Clinically Relevant Oncolytic Virus Platforms for Enhancing T Cell Therapy of Solid Tumors	32
LunX-CAR T Cells as a Targeted Therapy for Non-Small Cell Lung Cancer	32
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21	32
Electroporation of NKG2D RNA CAR Improves Vγ9Vδ2 T Cell Responses against Human Solid Tumor Xenografts	32
Analysis and Augmentation of the Immunologic Bystander Effects of CAR T Cell Therapy in a Syngeneic Mouse Cancer Model	32
Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma	31
SNHG1 knockdown upregulates miR-376a and downregulates FOXK1/Snail axis to prevent tumor growth and metastasis in HCC	30
m6A methyltransferase METTL3-mediated lncRNA FOXD2-AS1 promotes the tumorigenesis of cervical cancer	30
DCLK1 Regulates Tumor Stemness and Cisplatin Resistance in Non-small Cell Lung Cancer via ABCD-Member-4	30
microRNA-130b-3p contained in MSC-derived EVs promotes lung cancer progression by regulating the FOXO3/NFE2L2/TXNRD1 axis	29
The antitumor capacity of mesothelin-CAR-T cells in targeting solid tumors in mice	29
A New Tool for CRISPR-Cas13a-Based Cancer Gene Therapy	29
Hypomethylation Causes MIR21 Overexpression in Tumors	28
BRD4: An emerging prospective therapeutic target in glioma	28
Phase I trial of oncolytic adenovirus-mediated cytotoxic and interleukin-12 gene therapy for the treatment of metastatic pancreatic cancer	28
Landscape and perspectives of macrophage -targeted cancer therapy in clinical trials	28
SOX2 Promotes Brain Metastasis of Breast Cancer by Upregulating the Expression of FSCN1 and HBEGF	28
miR-7 Reduces Breast Cancer Stem Cell Metastasis via Inhibiting RELA to Decrease ESAM Expression	27
Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth	27
Genetic variants in m6A modification core genes are associated with glioma risk in Chinese children	27
CD133 mRNA-Loaded Dendritic Cell Vaccination Abrogates Glioma Stem Cell Propagation in Humanized Glioblastoma Mouse Model	27
Annexin A8 regulated by lncRNA-TUG1/miR-140-3p axis promotes bladder cancer progression and metastasis	27
Ectopic Expression of miR-532-3p Suppresses Bone Metastasis of Prostate Cancer Cells via Inactivating NF-κB Signaling	27
m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small cell lung cancer	26
miR-16-5p/PDK4-Mediated Metabolic Reprogramming Is Involved in Chemoresistance of Cervical Cancer	26
Defueling the cancer: ATP synthase as an emerging target in cancer therapy	26
Characterization of a novel OX40 ligand and CD40 ligand-expressing oncolytic adenovirus used in the PeptiCRAd cancer vaccine platform	26
Advances and new frontiers for immunotherapy in colorectal cancer: Setting the stage for neoadjuvant success?	25
Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme	25
Natural killer cells and immune-checkpoint inhibitor therapy: Current knowledge and new challenges	25
Systematic review of the immunological landscape of Wilms tumors	25

Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells	25
lncRNA DUXAP8 Facilitates Multiple Malignant Phenotypes and Resistance to PARP Inhibitor in HCC via Upregulating FOXM1	24
MGP Promotes Colon Cancer Proliferation by Activating the NF-κB Pathway through Upregulation of the Calcium Signaling Pathway	24
PSMA-Directed CAR T Cells Combined with Low-Dose Docetaxel Treatment Induce Tumor Regression in a Prostate Cancer Xenograft Model	24
Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas	24
Association of IDH mutation and 1p19q co-deletion with tumor immune microenvironment in lower-grade glioma	24
Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer	24
RETRACTED: miR-140-3p Inhibits Cutaneous Melanoma Progression by Disrupting AKT/p70S6K and JNK Pathways through ABHD2	24
Systemic delivery of TNF-armed myxoma virus plus immune checkpoint inhibitor eliminates lung metastatic mouse osteosarcoma	23
MMP25-AS1/hsa-miR-10a-5p/SERPINE1 axis as a novel prognostic biomarker associated with immune cell infiltration in KIRC	23
Regulatory role and mechanism of m6A RNA modification in human metabolic diseases	23
Histone Deacetylase Inhibitor Sensitizes ERCC1-High Non-small-Cell Lung Cancer Cells to Cisplatin via Regulating miR-149	22
Single-cell RNA-sequencing analyses identify heterogeneity of CD8+ T cell subpopulations and novel therapy targets in melanoma	22
Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes	22
Addition of BTK inhibitor orelabrutinib to rituximab improved anti-tumor effects in B cell lymphoma	22
Monocarboxylate Transporter 4 Is a Therapeutic Target in Non-small Cell Lung Cancer with Aerobic Glycolysis Preference	22
Inhibition of tumor invasion and metastasis by targeting TGF-β-Smad-MMP2 pathway with Asiatic acid and Naringenin	22
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2	22
WTAP Gene Variants Confer Hepatoblastoma Susceptibility: A Seven-Center Case-Control Study	21
A novel TanCAR targeting IL13Rα2 and EphA2 for enhanced glioblastoma therapy	21
A Cereblon Modulator CC-885 Induces CRBN- and p97-Dependent PLK1 Degradation and Synergizes with Volasertib to Suppress Lung Cancer	21
Targeting EGFR sensitizes 5-Fu-resistant colon cancer cells through modification of the lncRNA-FGD5-AS1-miR-330-3p-Hexokinase 2 axis	21
Scutellarin resensitizes oxaliplatin-resistant colorectal cancer cells to oxaliplatin treatment through inhibition of PKM2	21
Neoadjuvant Use of Oncolytic Herpes Virus G47Δ Enhances the Antitumor Efficacy of Radiofrequency Ablation	21
Exosomal miR-205-5p enhances angiogenesis and nasopharyngeal carcinoma metastasis by targeting desmocollin-2	21
Characterization of hypoxia response patterns identified prognosis and immunotherapy response in bladder cancer	20
Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4	20
The lncRNA DLGAP1-AS1/miR-149-5p/TGFB2 axis contributes to colorectal cancer progression and 5-FU resistance by regulating smad2 pathway	20
Mithramycin A and Mithralog EC-8042 Inhibit SETDB1 Expression and Its Oncogenic Activity in Malignant Melanoma	20
LRPPRC regulates metastasis and glycolysis by modulating autophagy and the ROS/HIF1-α pathway in retinoblastoma	20
Retargeted and Multi-cytokine-Armed Herpes Virus Is a Potent Cancer Endovaccine for Local and Systemic Anti-tumor Treatment	20
Irisin Is a Positive Regulator for Ferroptosis in Pancreatic Cancer	20
Imaging CAR T-cell kinetics in solid tumors: Translational implications	19
A brief review of reporter gene imaging in oncolytic virotherapy and gene therapy	19
Molecular Targeting of Cancer-Associated PCNA Interactions in Pancreatic Ductal Adenocarcinoma Using a Cell-Penetrating Peptide	19
Current strategies in engaging oncolytic viruses with antitumor immunity	19
The PABPC5/HCG15/ZNF331 Feedback Loop Regulates Vasculogenic Mimicry of Glioma via STAU1-Mediated mRNA Decay	19
Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases?	19
Highly efficient PD-1-targeted CRISPR-Cas9 for tumor-infiltrating lymphocyte-based adoptive T cell therapy	19
The long non-coding RNA SNHG4/microRNA-let-7e/KDM3A/p21 pathway is involved in the development of non-small cell lung cancer	19
Classification of pediatric gliomas based on immunological profiling: Implications for immunotherapy strategies	18
Lactate Dehydrogenase A Depletion Alters MyC-CaP Tumor Metabolism, Microenvironment, and CAR T Cell Therapy	18
lncRNA MIR503HG inhibits cell proliferation and promotes apoptosis in TNBC cells via the miR-224-5p/HOXA9 axis	18
AXL receptor is required for Zika virus strain MR-766 infection in human glioblastoma cell lines	18
METTL3 increases cisplatin chemosensitivity of cervical cancer cells via downregulation of the activity of RAGE	18
Circular RNA circRAB31 acts as a miR-885-5p sponge to suppress gastric cancer progression via the PTEN/PI3K/AKT pathway	18
miR-19a/b promote EMT and proliferation in glioma cells via SEPT7-AKT-NF-κB pathway	18
Antitumor Activity In Vivo and Vitro of New Chiral Derivatives of Baicalin and Induced Apoptosis via the PI3K/Akt Signaling Pathway	18
Boosting Replication and Penetration of Oncolytic Adenovirus by Paclitaxel Eradicate Peritoneal Metastasis of Gastric Cancer	18
Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma	18
Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seq	17
Oncolytic Zika virus promotes intratumoral T cell infiltration and improves immunotherapy efficacy in glioblastoma	17
Extending traditional antibody therapies: Novel discoveries in immunotherapy and clinical applications	17
The role of long non-coding RNAs in the pathogenesis of head and neck squamous cell carcinoma	17
Efficacy and safety of a third-generation oncolytic herpes virus G47Δ in models of human esophageal carcinoma	17
CXCR5 guides migration and tumor eradication of anti-EGFR chimeric antigen receptor T cells	17
Overexpression of YBX1 Promotes Pancreatic Ductal Adenocarcinoma Growth via the GSK3B/Cyclin D1/Cyclin E1 Pathway	17
Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis	17
Oncolytic reovirus-mediated recruitment of early innate immune responses reverses immunotherapy resistance in prostate tumors	17
lncRNA SNHG26 promoted the growth, metastasis, and cisplatin resistance of tongue squamous cell carcinoma through PGK1/Akt/mTOR signal pathway	17
miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3	17
Breast cancer tumor microenvironment affects Treg/IL-17-producing Treg/Th17 cell axis: Molecular and therapeutic perspectives	16
Progress and application of circulating tumor cells in non-small cell lung cancer	16
Long Non-coding RNA EPIC1 Promotes Cell Proliferation and Motility and Drug Resistance in Glioma	16
A novel PD-L1-targeted shark VNAR single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer	16
A PD1 targeted nano-delivery system based on epigenetic alterations of T cell responses in the treatment of gastric cancer	16
Design of an Interferon-Resistant Oncolytic HSV-1 Incorporating Redundant Safety Modalities for Improved Tolerability	16
Metformin inhibits gastric cancer cell proliferation by regulation of a novel Loc100506691-CHAC1 axis	16
Neural Stem Cells Improve the Delivery of Oncolytic Chimeric Orthopoxvirus in a Metastatic Ovarian Cancer Model	16
Tumor-derived exosomal microRNA-7-5p enhanced by verbascoside inhibits biological behaviors of glioblastoma in vitro and in vivo	16
Therapeutic potential of IBP as an autophagy inducer for treating lung cancer via blocking PAK1/Akt/mTOR signaling	16
Intracranial delivery of synthetic mRNA to suppress glioblastoma	16
miR-155 Accelerates the Growth of Human Liver Cancer Cells by Activating CDK2 via Targeting H3F3A	16
Improving the Efficacy of EGFR Inhibitors by Topical Treatment of Cutaneous Squamous Cell Carcinoma with miR-634 Ointment	16