OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Therapy-Oncolytics is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Promoting role of pentraxin-3 in esophageal squamous cell carcinoma	133
LINC01296 promotes neuroblastoma tumorigenesis via the NCL-SOX11 regulatory complex	104
Extracellular vesicle contents as non-invasive biomarkers in ovarian malignancies	103
Azelnidipine inhibits esophageal squamous cell carcinoma proliferation in vivo and in vitro by targeting MEK1/2	69
Radiovirotherapy at twenty	64
Dynamic fine-tuning of CAR-T cell therapy	61
Thank you to our 2022 reviewers	60
hnRNPK-derived cell-penetrating peptide inhibits cancer cell survival	53
Sperm protein 17 targeting for epithelial ovarian cancer treatment in the era of modern immunoengineering	50
Lentiviral interferon: A novel method for gene therapy in bladder cancer	50
esRAGE-expressing oHSV enhances anti-tumor efficacy by inhibition of endothelial cell activation	47
Vorolanib, a novel tyrosine receptor kinase receptor inhibitor with potent preclinical anti-angiogenic and anti-tumor activity	46
Oncolytic Zika virus promotes intratumoral T cell infiltration and improves immunotherapy efficacy in glioblastoma	44
MicroRNA-sensitive oncolytic measles virus for chemovirotherapy of pancreatic cancer	44
Upregulation of endogenous TRAIL-elicited apoptosis is essential for metformin-mediated antitumor activity against TNBC and NSCLC	44
Retraction Notice to: miR-140-3p Inhibits Cutaneous Melanoma Progression by Disrupting AKT/p70S6K and JNK Pathways through ABHD2	43
R. Daniel Beauchamp (1946–2022)	42
Oncolytic vaccinia virus injected intravenously sensitizes pancreatic neuroendocrine tumors and metastases to immune checkpoint blockade	42
Bacterial cancer therapy using the attenuated fowl-adapted Salmonella enterica serovar Gallinarum	38
The tRNA-derived fragment signature in lung cancer	38
Pre-treatment with systemic agents for advanced NSCLC elicits changes in the phenotype of autologous T cell therapy products	38
PET imaging and treatment of pancreatic cancer peritoneal carcinomatosis after subcutaneous intratumoral administration of a novel oncolytic virus, CF33-hNIS-antiPDL1	38
RETRACTED: Comprehensive analysis of FKBP4/NR3C1/TMEM173 signaling pathway in triple-negative breast cancer cell and dendritic cell among tumor microenvironment	37
Single-cell transcriptomics reveal DHX9 in mature B cell as a dynamic network biomarker before lymph node metastasis in CRC	36
NEBL and AKT1 maybe new targets to eliminate the colorectal cancer cells resistance to oncolytic effect of vesicular stomatitis virus M-protein	36

Regulation of CD19 CAR-T cell activation based on an engineered downstream transcription factor	35
Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model	35
A novel TanCAR targeting IL13Rα2 and EphA2 for enhanced glioblastoma therapy	34
LRPPRC regulates metastasis and glycolysis by modulating autophagy and the ROS/HIF1-α pathway in retinoblastoma	34
Characterization and quantitation of busulfan DNA adducts in the blood of patients receiving busulfan therapy	33
Ferroptosis gene signature in cholangiocarcinoma	33
Neoadjuvant use of oncolytic herpes virus G47Δ prevents local recurrence after insufficient resection in tongue cancer models	33
Dual blockade of CD47 and CD24 signaling using a novel bispecific antibody fusion protein enhances macrophage immunotherapy	32
Next generation oncolytic viruses expressing PADI1 and TIMP2 exhibit anti-tumor activity against melanoma in nude and humanized mouse models	32
Oncogenic lncRNA BBOX1-AS1 promotes PHF8-mediated autophagy and elicits sorafenib resistance in hepatocellular carcinoma	31
Adding recombinant AAVs to the cancer therapeutics mix	31
A PD1 targeted nano-delivery system based on epigenetic alterations of T cell responses in the treatment of gastric cancer	31
Targeting carcinoembryonic antigen-expressing tumors using a novel transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1	31
The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy	30
Intratumoral delivery of a novel oncolytic adenovirus encoding human antibody against PD-1 elicits enhanced antitumor efficacy	29
Efficacy of a third-generation oncolytic herpes simplex virus in refractory soft tissue sarcoma xenograft models	28
Polycytidine tract deletion from microRNA-detargeted oncolytic Mengovirus optimizes the therapeutic index in a murine multiple myeloma model	27
Metabolic remodeling in tumor-associated macrophages contributing to antitumor activity of cryptotanshinone by regulating TRAF6-ASK1 axis	26
Claudin18.2 bispecific T cell engager armed oncolytic virus enhances antitumor effects against pancreatic cancer	25
A novel CD34-derived hinge for rapid and efficient detection and enrichment of CAR T cells	25
Expanding the landscape of TCR gene therapy targeting MAGE	24
SNHG1 knockdown upregulates miR-376a and downregulates FOXK1/Snail axis to prevent tumor growth and metastasis in HCC	24
circBANP promotes colorectal cancer growth and metastasis via sponging let-7d-5p to modulate HMGA1/Wnt/β-catenin signaling	24
Spatiotemporal analysis of induced neural stem cell therapy to overcome advanced glioblastoma recurrence	23
Deletion of immunomodulatory genes as a novel approach to oncolytic vaccinia virus development	23
Transgenic viral expression of PH-20, IL-12, and sPD1-Fc enhances immune cell infiltration and anti-tumor efficacy of an oncolytic virus	23
DNA-methylation-induced silencing of DIO3OS drives non-small cell lung cancer progression via activating hnRNPK-MYC-CDC25A axis	23
Nanobody-based retargeting of an oncolytic herpesvirus for eliminating CXCR4+ GBM cells: A proof of principle	23
Improved lentiviral vector titers from a multi-gene knockout packaging line	23
The next wave of cellular immunotherapies in pancreatic cancer	22
Novel roles of METTL1/WDR4 in tumor via m7G methylation	22
Icaritin inhibits PLK1 to activate DNA damage response in NK/T cell lymphoma and increases sensitivity to GELOX regime	22
Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma	22
Lazertinib improves the efficacy of chemotherapeutic drugs in ABCB1 or ABCG2 overexpression cancer cells in vitro, in vivo, and ex vivo	22
Nucleic acids and proteins carried by exosomes of different origins as potential biomarkers for gynecologic cancers	22
TRIM22 orchestrates the proliferation of GBMs and the benefits of TMZ by coordinating the modification and degradation of RIG-I	22
Regulatory role and mechanism of m6A RNA modification in human metabolic diseases	22
PBX3-activated DLG1-AS1 can promote the proliferation, invasion, and migration of TNBC cells by sponging miR-16-5p	21
Oncolytic virotherapy with intratumoral injection of vaccinia virus TG6002 and 5-fluorocytosine administration in dogs with malignant tumors	21
Systematic profiling of ferroptosis gene signatures predicts prognostic factors in esophageal squamous cell carcinoma	21
Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seq	21
Combination of a STAT3 inhibitor with anti-PD-1 immunotherapy is an effective treatment regimen for a vemurafenib-resistant melanoma	21
Synthetic mRNA-based gene therapy for glioblastoma: TRAIL-mRNA synergistically enhances PTEN-mRNA-based therapy	21
Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis	21
Efficacy and safety of a third-generation oncolytic herpes virus G47Δ in models of human esophageal carcinoma	20
PTEN potentiation of oncolytic HSV therapy for glioblastoma	20
The pivotal regulatory factor circBRWD1 inhibits arsenic exposure-induced lung cancer occurrence by binding mRNA and regulating its stability	20
Reinvigoration of innate and adaptive immunity via therapeutic cellular vaccine for patients with AML	20
LINC00461 facilitates HNSCC development and reduces chemosensitivity by impairing miR-195-mediated inhibition of HOXA10	20
Development of a 5-FU modified miR-129 mimic as a therapeutic for non-small cell lung cancer	20

Enhanced tumor targeting and timely viral release of mesenchymal stem cells/oncolytic virus complex due to GRP78 and inducible E1B55K expressions greatly increase the antitumor effect of systemic trea	19
A systematic analysis on the clinical safety and efficacy of onco-virotherapy	19
Interleukin-6-controlled, mesenchymal stem cell-based sodium/iodide symporter gene therapy improves survival of glioblastoma-bearing mice	19
Narciclasine targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells	19
Palmitoylated antigens for the induction of anti-tumor CD8+ T cells and enhanced tumor recognition	19
Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors	19
Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model	19
RHAMMB-mediated bifunctional nanotherapy targeting Bcl-xL and mitochondria for pancreatic neuroendocrine tumor treatment	19
Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation	19
Treatment of glioblastoma with current oHSV variants reveals differences in efficacy and immune cell recruitment	19
lncRNA MIR503HG inhibits cell proliferation and promotes apoptosis in TNBC cells via the miR-224-5p/HOXA9 axis	19
Oncolytic virotherapy targeting the IL15 pathway	18
Diversity in responses to oncolytic Lassa-vesicular stomatitis virus in patient-derived glioblastoma cells	18
The quest for effective immunotherapies against malignant peripheral nerve sheath tumors: Is there hope?	18
Infection of non-cancer cells: A barrier or support for oncolytic virotherapy?	18
Therapeutic effects of TM4SF5-targeting chimeric and humanized monoclonal antibodies in hepatocellular and colon cancer models	18
MicroRNA-detargeting proves more effective than leader gene deletion for improving safety of oncolytic Mengovirus in a nude mouse model	18
Chandipura virus induces cell death in cancer cell lines of human origin and promotes tumor regression in vivo	18
Metformin preferentially enhances the radio-sensitivity of cancer stem-like cells with highly mitochondrial respiration ability in HMPOS	18
IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma	18
Gene-edited and CAR-NK cells: Opportunities and challenges with engineering of NK cells for immunotherapy	17
Treatment with the PPARα agonist fenofibrate improves the efficacy of CD8+ T cell therapy for melanoma	17
Oncolytic adenovirus for treatment of malignant ascites	17
Quantitative proteomics characterization of cancer biomarkers and treatment	17
Zika virus cleaves GSDMD to disseminate prognosticable and controllable oncolysis in a human glioblastoma cell model	17
A novel anti-B7-H3 chimeric antigen receptor from a single-chain antibody library for immunotherapy of solid cancers	17
Modulation of p53 expression in cancer-associated fibroblasts prevents peritoneal metastasis of gastric cancer	17
Thank you to our 2021 reviewers	17