OOIR: Observatory of International Research

Papers

(The TQCC of ACS Central Science is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Pyrazinone Biosynthesis and Signaling─Myxo Style	299
Alexandrian Cut in Downstream Lignin Valorization to Yield Novel Plasticizers	294
Issue Editorial Masthead	190
A Regiospecific Co-Assembly Method to Functionalize Ordered Mesoporous Metal Oxides with Customizable Noble Metal Nanocrystals	167
High-Speed Sequential DNA Computing Using a Solid-State DNA Origami Register	166
Zooming in on the Glycome: Visualizing Glycans at the Nanoscale Level through Expansion Microscopy	163
Pumping Iron for Tuberculosis Diagnostics	155
Issue Publication Information	140
The Utility of Cyclodextrin for Countering μ-Opioid Receptor Drug Overdoses	139
Stationary DNA Origami Register Drives Fast Sequential DNA Computing	137
General Synthesis of Large Inorganic Nanosheets via 2D Confined Assembly of Nanoparticles	127
Mechanical Bond Approach to Introducing Self-Adaptive Active Sites in Covalent Organic Frameworks for Zinc-Catalyzed Organophosphorus Degradation	124
Plasmonic Alloys Enhanced Metabolic Fingerprints for the Diagnosis of COPD and Exacerbations	122
Issue Publication Information	118
A Conversation with Francis Collins	111
Issue Editorial Masthead	107
Life as a Chronically Ill PhD Student	104
Is Fluorinating Polyethylene a Health Threat?	99
Biomolecular Chirality Is Imprinted on One Layer of Hydration Water	98
Manipulating Tyrosine Phosphorylation by Heterobifunctional Small Molecules	98
Teaching Chemistry Labs from a Distance	96
Issue Publication Information	96
Correspondence on “An International Study Evaluating Elemental Analysis”	95
Silanol-Assisted High-Yield Nanofabrication of SnO₂ Single Crystals with Highly Tunable and Ordered Mesoporosity	94
Caught in the Act of Substitution: Interadsorbate Effects on an Atomically Precise Fe/Co/Se Nanocluster	85

Correction to “O-GlcNAcylation Facilitates the Interaction between Keratin 18 and Isocitrate Dehydrogenases and Potentially Influencing Cholangiocarcinoma Progression”	84
ERCAD: A Parametric Reactor Design Tool That Enables Rapid Prototyping and Optimization of Electrochemical Reactors through 3D Printing	82
Discovering Relationships between OSDAs and Zeolites through Data Mining and Generative Neural Networks	81
Rational Vaccinology: Harnessing Nanoscale Chemical Design for Cancer Immunotherapy	79
Atomically Precise Enantiopure Bimetallic Janus Clusters	79
Heterogeneous Charged Complexes of Random Copolymers for the Segregation of Organic Molecules	79
Phage-Assisted Continuous Evolution and Selection of Enzymes for Chemical Synthesis	78
Mechanochemical Oxidative Degradation of Thienopyridine Containing Drugs: Toward a Simple Tool for the Prediction of Drug Stability	77
Building a Porous Molecular Machine That Replicates Natural Enzymes	77
Ni- and Ni/Pd-Catalyzed Reductive Coupling of Lignin-Derived Aromatics to Access Biobased Plasticizers	75
Polyethylenimine–Poly(lactic-co-glycolic acid)₂ Nanoparticles Show an Innate Targeting Ability to the Submandibular Salivary Gland via the Muscarinic 3 Receptor	75
Controllable Phycobilin Modification: An Alternative Photoacclimation Response in Cryptophyte Algae	74
Absolute Affinities from Quantitative Shotgun Glycomics Using Concentration-Independent (COIN) Native Mass Spectrometry	71
Diffusive Dynamics of Bacterial Proteome as a Proxy of Cell Death	70
A Sample-Centric and Knowledge-Driven Computational Framework for Natural Products Drug Discovery	69
Mapping Protein–Protein Interactions at Birth: Single-Particle Cryo-EM Analysis of a Ribosome–Nascent Globin Complex	69
Exploring Structure–Activity Relationships and Modes of Action of Laterocidine	68
PEARL-Catalyzed Peptide Bond Formation after Chain Reversal by Ureido-Forming Condensation Domains	68
Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells	68
Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase	67
Cascade Strand Displacement and Bipedal Walking Based DNA Logic System for miRNA Diagnostics	66
An Electrolyte with Elevated Average Valence for Suppressing the Capacity Decay of Vanadium Redox Flow Batteries	65
Total Synthesis of Poisonous Aconitum Alkaloids Empowered by a Fragment Coupling Strategy	64
A Conversation with Clare Grey	64
Issue Editorial Masthead	64
Issue Editorial Masthead	64
A Conversation with Karina Sand	63
Spiro-strain Takes Chemiluminescence to Flash-Mode	63
Issue Publication Information	63
Issue Editorial Masthead	61
Issue Editorial Masthead	60
A Conversation with Maiken Ueland	59
Issue Publication Information	59
A Conversation with Loreto Paulino Jr.	57
A Conversation with Kayla Ivey	57
Electrochemistry Cracks the P–O Bond: Sustainable Reduction of Phosphates to Phosphorus	56
A Conversation with Wil Srubar	56
Issue Editorial Masthead	55
Fantastic Frustrated Materials–and Where to Find Them	55
Development of an Effective Monoclonal Antibody against Heroin and Its Metabolites Reveals Therapies Have Mistargeted 6-Monoacetylmorphine and Morphine over Heroin	55
New Rocaglate Derivatives Tip the Scale against Brain Tumors	55
A Conversation with Karin Öberg	54
Making Natural Products Supernatural	53
Issue Publication Information	53
Issue Publication Information	53
Deep Learning-Driven Library Design for the De Novo Discovery of Bioactive Thiopeptides	52
The Animation Lab Brings Molecules to Life	52
Offsetting Low-Affinity Carbohydrate Binding with Covalency to Engage Sugar-Specific Proteins for Tumor-Immune Proximity Induction	51
Real-Time Monitoring of the Level and Activity of Intracellular Glutathione in Live Cells at Atomic Resolution by ¹⁹F-NMR	51
Electrochemical Cation-Swing for Carbon Capture under Ambient Conditions	50

Teaching an Old Dog New Tricks for Achieving CB₂-Selective Inverse Agonism	49
Issue Publication Information	49
Substrate-Selective Catalysis Enabled Synthesis of Azaphilone Natural Products	49
Proteomics Offers New Clues for Forensic Investigations	49
Halide Perovskites Breathe Too: The Iodide–Iodine Equilibrium and Self-Doping in Cs₂SnI₆	48
GEN-Click: Genetically Encodable Click Reactions for Spatially Restricted Metabolite Labeling	48
Biocompatible Lysine Protecting Groups for the Chemoenzymatic Synthesis of K48/K63 Heterotypic and Branched Ubiquitin Chains	47
Edible Matrix Code with Photogenic Silk Proteins	46
Catching Threads in Bacterial Cell Walls	45
Distinct Modes of Hidden Structural Dynamics in the Functioning of an Allosteric Polysaccharide Lyase	45
Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform	45
Inverse Design of Pore Wall Chemistry To Control Solute Transport and Selectivity	44
Sulfonylation of RNA 2′-OH groups	43
Lectin Fingerprinting Distinguishes Antibody Neutralization in SARS-CoV-2	43
A Systematic Approach to the Discovery of Protein–Protein Interaction Stabilizers	43
High-Entropy Engineering in Hollow Layered Hydroxide Arrays to Boost 5-Hydroxymethylfurfural Electrooxidation by Suppressing Oxygen Evolution	43
Protein Structure-Based Organic Chemistry-Driven Ligand Design from Ultralarge Chemical Spaces	42
HOPS-Dependent Endosomal Escape Demands Protein Unfolding	42
“For Its Size, the Most Complex Natural Product Known.” Who Deserves Credit for Determining the Structure of Strychnine?	42
Detecting the First Hydration Shell Structure around Biomolecules at Interfaces	42
Spatiotemporal Regulation of Cell Fate in Living Systems Using Photoactivatable Artificial DNA Membraneless Organelles	42
Helical Polymer Working as a Chirality Amplifier to Generate and Modulate Multicolor Circularly Polarized Luminescence in Small Molecular Fluorophore/Polymer Composite Films	41
Janus Emulsion Biosensors for Anti-SARS-CoV-2 Spike Antibody	41
A New Facility Will Harness Plasma to Guide Interplanetary Craft	41
Intracellular Relaxometry, Challenges, and Future Directions	41
Bespoke and Accessible Electrochemical Reactors	40
Pinpointing the Onset of Water Harvesting in Reticular Frameworks from Structure	40
Bicyclic Schellman Loop Mimics (BSMs): Rigid Synthetic C-Caps for Enforcing Peptide Helicity	40
Chemical Sensors and Imaging: Molecular, Materials, and Biological Platforms	40
Modular Integration of Hydrogel Neural Interfaces	39
Recycling of Post-Consumer Waste Polystyrene Using Commercial Plastic Additives	39
Visualizing Composition and Functionality of Porous Catalysts Using Dual-Emissive Fluorescent Nanoprobes	39
Dual-Selective Catalysis in Dephosphorylation Tuned by Hf₆-Containing Metal–Organic Frameworks Mimicking Phosphatase	38
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction	38
The Tautomeric State of N⁴-Hydroxycytidine within Base-Paired RNA	38
Natural-Product-Directed Catalytic Stereoselective Synthesis of Functionalized Fused Borane Cluster–Oxazoles for the Discovery of Bactericidal Agents	38
GlycoGrip: Cell Surface-Inspired Universal Sensor for Betacoronaviruses	38
Radiochemistry: A Hot Field with Opportunities for Cool Chemistry	38
Origin of Proteolytic Stability of Peptide-Brush Polymers as Globular Proteomimetics	37
CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2	37
In Silico Discovery of 5′-Modified 7-Deoxy-7-ethynyl-4′-thioadenosine as a HASPIN Inhibitor and Its Synergistic Anticancer Effect with the PLK1 Inhibitor	37
Enantioseparation in Hierarchically Porous Assemblies of Homochiral Cages	37
Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months	37
High-Performance Genetically Encoded Green Fluorescent Biosensors for Intracellular l-Lactate	36
Transition State Theory-Inspired Neural Network for Estimating the Viscosity of Deep Eutectic Solvents	36
Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome	36
Multielectrode Spectroscopy Enables Rapid and Sensitive Molecular Profiling of Extracellular Vesicles	36
Trace Hydrogen Sulfide Sensing Inspired by Polyoxometalate-Mediated Aerobic Oxidation	36
MOF Linker Extension Strategy for Enhanced Atmospheric Water Harvesting	35
Discovering New Chemistry with an Autonomous Robotic Platform Driven by a Reactivity-Seeking Neural Network	35
A Hitchhiker’s Guide to Problem Selection in Carbohydrate Synthesis	35
Task-Driven Tailored Covalent Organic Framework for Dynamic Capture of Trace Radioactive CH₃¹³¹I under High-Flow Rate Conditions	34
β-Amino Acids Reduce Ternary Complex Stability and Alter the Translation Elongation Mechanism	34
Probing the Origin of Affinity in the GM1-Cholera Toxin Complex through Site-Selective Editing with Fluorine	33
Real-Time Fast Amyloid Seeding and Translocation of α-Synuclein with a Nanopipette	33
Hydrazine-Hydrazide-Linked Covalent Organic Frameworks for Water Harvesting	33
Identification and Detection of a Peptide Biomarker and Its Enantiomer by Nanopore	33
Stable Isotopomers of myo-Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network	33
Commemorating The Nobel Prize in Chemistry 2023 for the Discovery and Synthesis of Quantum Dots	33
Interrogating RNA–Small Molecule Interactions with Structure Probing and Artificial Intelligence-Augmented Molecular Simulations	33
An Ecosystem for Digital Reticular Chemistry	33
Closed-Loop Electrolyte Design for Lithium-Mediated Ammonia Synthesis	32
Synthesis, Microbiology, and Biophysical Characterization of Mutanofactins from the Human Oral Microbiome	32
How Does the Rate of Chain Exchange Relate to Stress Relaxation in Triblock Copolymer Networks?	32
Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules	31
Carbon-Centered Radicals in Protein Manipulation	31
Tuning Single-Polymer Growth via Hydrogen Bonding in Conformational Entanglements	31
Ultra-High Purity and Productivity Separation of CO₂ and C₂H₂ from CH₄ in Rigid Layered Ultramicroporous Material	31
Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics	31
Tailoring and Identifying Brønsted Acid Sites on Metal Oxo-Clusters of Metal–Organic Frameworks for Catalytic Transformation	31
Asymmetric Non-Fullerene Small-Molecule Acceptors toward High-Performance Organic Solar Cells	30
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections	30
Creation of Cationic Polymeric Nanotrap Featuring High Anion Density and Exceptional Alkaline Stability for Highly Efficient Pertechnetate Removal from Nuclear Waste Streams	30
Dataset Design for Building Models of Chemical Reactivity	30
Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders	30
Dual Salt Cation-Swing Process for Electrochemical CO₂ Separation	29
Controlled Preparation of Single-Walled Carbon Nanotubes as Materials for Electronics	28
Discovery of the Highly Selective and Potent STAT3 Inhibitor for Pancreatic Cancer Treatment	28
Nature Chose Phosphates and Chemists Should Too: How Emerging P(V) Methods Can Augment Existing Strategies	28
A Simple yet Efficient Hydrophilic Phenanthroline-Based Ligand for Selective Am(III) Separation under High Acidity	28

Site-Specific Acetylation of the Transcription Factor Protein Max Modulates Its DNA Binding Activity	28
Probing Kinetics of Water-in-Salt Aqueous Batteries with Thick Porous Electrodes	28
Promoting CO₂ Electroreduction to Acetate by an Amine-Terminal, Dendrimer-Functionalized Cu Catalyst	28
Solvent Gaming Chemistry to Control the Quality of Halide Perovskite Thin Films for Photovoltaics	27
Inhibiting Dendrite Growth via Regulating the Electrified Interface for Fast-Charging Lithium Metal Anode	27
Challenging Reaction Prediction Models to Generalize to Novel Chemistry	27
A Conversation with Leo Gross	27
Homogeneously Mixing Different Metal–Organic Framework Structures in Single Nanocrystals through Forming Solid Solutions	27
Molecular Prosthetics for Long-Term Functional Imaging with Fluorescent Reporters	27
Photoproximity Labeling from Single Catalyst Sites Allows Calibration and Increased Resolution for Carbene Labeling of Protein Partners In Vitro and on Cells	27
Researchers Face Challenges Devising a PFAS-Free Future	27
Continuum Crystallization Model Derived from Pharmaceutical Crystallization Mechanisms	27
The Evolution of Data-Driven Modeling in Organic Chemistry	27
Searching for the Truth: Elemental Analysis–A Powerful but Often Poorly Executed Technique	27
The Spin-Phonon Relaxation Mechanism of Single-Molecule Magnets in the Presence of Strong Exchange Coupling	27
Science That Looks Like Me, That Looks Like Us	26
A Conversation with Fay Probert	26
Automated Research Platform for Development of Triplet–Triplet Annihilation Photon Upconversion Systems	26
Issue Editorial Masthead	26
Long COVID Researchers Are on the Hunt for Causes and Cures	26
Issue Editorial Masthead	26
Plastic Pores for Switchable and Optimized Adsorption Behaviors	26
Issue Publication Information	26
Zoogeochemists Measure How Muddy Animals Change Their Environments’ Chemistry	26
Issue Editorial Masthead	26
A Conversation with Carolyn Pearce	26
Cationic Catalysts as a New Strategy to Catalyze N-Carboxyanhydrides Polymerization	26
Issue Publication Information	25
A Chemical Tool for Guiding Li Therapy	25
Bioinspired, Carbohydrate-Containing Polymers Efficiently and Reversibly Sequester Heavy Metals	25
Issue Publication Information	25
A Conversation with Najat Saliba	25
A Conversation with Julie Dunne	25
Understanding Oxygen-Induced Reactions and Their Impact on n-Type Polymeric Mixed Conductor-Based Devices	25
Issue Editorial Masthead	25
Issue Publication Information	25
Stephanie Beaupark Sees Chemistry Through an Indigenous Lens	25
Issue Publication Information	25
Proton-Transfer Dynamics Regulates CO₂ Electroreduction Products via Hydrogen Coverage	24
Chemoadaptive Polymeric Assemblies by Integrated Chemical Feedback in Self-Assembled Synthetic Protocells	24
Issue Publication Information	24
Issue Publication Information	24
Issue Publication Information	24
From Beam Damage to Massive Reaction Amplification under the Electron Microscope: An Ionization-Induced Chain Reaction in Crystals of a Dewar Benzene	24
Lipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress	24
A Conversation with Noah Whiteman	24
3D Printers Enter the Kitchen	24
Correction to “A Conversation with Liangbing Hu”	24
Spectroscopic Signatures of Phonon Character in Molecular Electron Spin Relaxation	24
Automating Glycan Assembly in Solution	24
Issue Editorial Masthead	24
Issue Publication Information	24
A Conversation with Sébastien Vidal	24
Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia	23
Nickel(II) Catalyzed Atroposelective Aerobic Oxidative Aryl–Aryl Cross-Coupling	23
Is Europe Running out of Chemistry Teachers?	23
Directed Gas-Phase Formation of Azulene (C₁₀H₈): Unraveling the Bottom-Up Chemistry of Saddle-Shaped Aromatics	23
Surface Curvature Matters in Electrochemical Reactions	23
Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice	23
A Collagen Triple Helix without the Superhelical Twist	23
Transforming Aluminum-Ion Batteries with Recyclable Solid-State Electrolytes	23
Direct (LC-)MS Identification of Regioisomers from C–H Functionalization by Partial Isotopic Labeling	23
Scratching the Surface of Individual Aerosol Particle Properties	23
Issue Editorial Masthead	22
A Pair of Fluorescent Probes Enabling Precise Diagnosis of Liver Cancer by Complementary Imaging	22
Issue Editorial Masthead	22
Light-Harvesting: The Never-Ending Lesson of Nature	22
A Layered Organic Cathode for High-Energy, Fast-Charging, and Long-Lasting Li-Ion Batteries	22
Can Diabetes Drugs like Ozempic Tackle the Mental Health Crisis?	22
Start-Ups Are Supercharging Algae to Clean Up the Environment	22
Unlocking Efficient O₂ Electroreduction in Conductive MOFs via Enhanced Mass Transport	22
Evidential Deep Learning for Guided Molecular Property Prediction and Discovery	22
Issue Editorial Masthead	22
A Conversation with Raffaele Mezzenga	22
Remote Sensing for Crops Spots Pests and Pathogens	21
What Makes a Good Protein–Protein Interaction Stabilizer: Analysis and Application of the Dual-Binding Mechanism	21
Bioorthogonal Chemical Ligation Creates Synthetic Antibodies with Improved Therapeutic Potency	21
LUNAS: A Rapid and Sensitive Nucleic Acid Detection Assay Using Split NanoLuc Luciferase Complementation	21
Predicting the Plateau Modulus from Molecular Parameters of Conjugated Polymers	21
A Greener Vision for P–C Bond Formation	21
Computational and Experimental Approaches to Controlling Bacterial Microcompartment Assembly	21
Nickel-Catalyzed Enantio- and Diastereoselective Synthesis of Fluorine-Containing Vicinal Stereogenic Centers	20
Correction to “New Pathway for Cisplatin Prodrug to Utilize Metabolic Substrate Preference to Overcome Cancer Intrinsic Resistance”	20
Electronic Excited States from Physically Constrained Machine Learning	20
Exploring Uncharted Territory: Toward Metabolite Network Maps	20
A Semisynthetic Oligomannuronic Acid-Based Glycoconjugate Vaccine against Pseudomonas aeruginosa	20
Small-Molecule Inhibition of Androgen Receptor Dimerization as a Strategy against Prostate Cancer	20
Hydrocarbon Oxidation by an Exposed, Multiply Bonded Iron(III) Oxo Complex	19
Engineered Bioluminescent Indicator Enables the Brain Imaging of Kinase Inhibitors	19
High-Throughput Evaluation of Emission and Structure in Reduced-Dimensional Perovskites	19
All-Atom Mesoscale Simulations Predict the Conformational Dynamics of Influenza Virus Surface Glycoproteins	19
Host Cell Membrane Capture by the SARS-CoV-2 Spike Protein Fusion Intermediate	19
The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella	19
Tetranucleosome Interactions Drive Chromatin Folding	19
Asymmetric Syntheses of (+)- and (−)-Collybolide Enable Reevaluation of kappa-Opioid Receptor Agonism	19