Science Advances

Article	Citations
Discovery of an autoinhibited conformation in mesotrypsin reveals a strategy for selective serine protease inhibition	1470
Anabolic indices of matrix proteins identify regenerative small RNA intrinsic to human cartilage	546
Global health risks lurking in livestock resistome	427
DNA damage response pathway regulates Nrf2 in response to oxidative stress	421
Role of HAUS7 as a DOCK3 binding partner in facilitating axon regeneration	375
Hidden white and black feather layers enhance plumage coloration in tanagers and other songbirds	349
Bone-inspired stress-gaining elastomer enabled by dynamic molecular locking	296
Diving into the vertical dimension of elasmobranch movement ecology	289
Artificial biomarker-based feedback-regulated personalized and precise thrombolysis with lower hemorrhagic risk	278
Upward propagation of gigantic jets revealed by 3D radio and optical mapping	266
DNA repair during nonreductional meiosis in the asexual rotifer Adineta vaga	262
Focusing of in-plane hyperbolic polaritons in van der Waals crystals with tailored infrared nanoantennas	260
2D material exciton-polariton transport on 2D photonic crystals	259
Real-time antiproton annihilation vertexing with submicrometer resolution	257
Distinct armchair and zigzag charge transport through single polycyclic aromatics	257
Sensing spin wave excitations by spin defects in few-layer-thick hexagonal boron nitride	250
Kir7.1 is the physiological target for hormones and steroids that regulate uteroplacental function	246
Particle-armored liquid robots	245
Multiplexed mapping of the interactome of GPCRs with receptor activity–modifying proteins	239
Cold exposure stimulates cross-tissue metabolic rewiring to fuel glucose-dependent thermogenesis in brown adipose tissue	239
Uncertainties too large to predict tipping times of major Earth system components from historical data	237
Mismatched ligand density enables ordered assembly of mixed-dimensional, cross-species materials	234
Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ	231
Deep and dynamic metabolic and structural imaging in living tissues	230
Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions of tau into amyloid fibrils	229

A printed luminescent flier inspired by plant seeds for eco-friendly physical sensing	229
Spatially resolved single-cell atlas of ascidian endostyle provides insight into the origin of vertebrate pharyngeal organs	227
GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury	222
Bound chiral magnonic polariton states for ideal microwave isolation	222
Laws about bodily damage originate from shared intuitions about the value of body parts	219
Abiotic molecular oxygen production—Ionic pathway from sulfur dioxide	217
Oxygen isotopes of anhydrous primary minerals show kinship between asteroid Ryugu and comet 81P/Wild2	213
Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy	211
Enhancer dynamics: Unraveling the mechanism of transcriptional bursting	211
High coherence and low cross-talk in a tileable 3D integrated superconducting circuit architecture	211
6mA-Sniper: Quantifying 6mA sites in eukaryotes at single-nucleotide resolution	210
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress	210
GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency	209
Predicting three-component reaction outcomes from ~40,000 miniaturized reactant combinations	206
Diamond-based microwave quantum amplifier	205
Complementary corticostriatal circuits orchestrate action repetition and switching	204
Signatures of speech and song: “Universal” links despite cultural diversity	204
Enhanced Rap1 small GTPase activity in the ventral hippocampus drives stress-induced anxiety	203
Structure and dynamics determine G protein coupling specificity at a class A GPCR	201
Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes	200
In vivo mapping of cellular resolution neuropathology in brain ischemia with diffusion MRI	200
Blind identification of the spinal cord output in humans with high-density electrode arrays implanted in muscles	199
A radio pulsar phase from SGR J1935+2154 provides clues to the magnetar FRB mechanism	199
The molecular mechanism of sialic acid transport mediated by Sialin	196
Fungal-fungal cocultivation leads to widespread secondary metabolite alteration requiring the partial loss-of-function VeA1 protein	195
If you rise, I fall: Equality is prevented by the misperception that it harms advantaged groups	195
Optical control of 4 f orbital state in rare-earth metals	192
Attentional guidance through object associations in visual cortex	186
Oral iron sulfide prevents acute alcohol intoxication by initiating the endogenous multienzymatic antioxidant defense system	186
Biological export production controls upper ocean calcium carbonate dissolution and CO 2 buffer capacity	184
Editor’s note and erratum for the Research Article: “Unemployment and underemployment are causes of suicide”	183
The extinct shark Otodus megalodon was a transoceanic superpredator: Inferences from 3D modeling	182
N -Heterocyclic carbene catalytic 1,2-boron migrative acylation accelerated by photocatalysis	182
Fast cortical dynamics encode tactile grating orientation during active touch	182
Quantifying structural relationships of metal-binding sites suggests origins of biological electron transfer	182
Massively parallel quantification of phenotypic heterogeneity in single-cell drug responses	181
Truncated jarid2 and kdm6b transcripts are associated with temperature-induced sex reversal during development in a dragon lizard	181
Palimpsest memories stored in memristive synapses	179
Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis	178
Saturn’s F ring is intermittently shepherded by Prometheus	177
Gating of hair cell Ca 2+ channels governs the activity of cochlear neurons	176
Modularized microrobot with lock-and-detachable modules for targeted cell delivery in bile duct	175
Chromobacterium biopesticide overcomes insecticide resistance in malaria vector mosquitoes	175
Hibiscus bullseyes reveal mechanisms controlling petal pattern proportions that influence plant-pollinator interactions	174
Engineering is pregnant with possibilities	174
The genomic landscape of familial glioma	173
Age-dependent acquisition of pathogenicity by SARS-CoV-2 Omicron BA.5	170
Miniature battery-free epidural cortical stimulators	169
Metasurface-based realization of photonic time crystals	169
Developmentally programmed histone H3 expression regulates cellular plasticity at the parental-to-early embryo transition	166

Separation and recycling of hydrofluorocarbon refrigerant mixtures with fluoropolymer-coated hollow fiber membranes	166
Erratum for the Research Article: “SMAD4, activated by the TCR-triggered MEK/ERK signaling pathway, critically regulates CD8 + T cell cytotoxic function” by X. Liu	166
Smart ultra-long-lasting sequentially triggerable and artfully implantable nozzle system for on-demand drug delivery for chronotherapy	166
Molybdate uptake interplay with ROS tolerance modulates bacterial pathogenesis	164
Wnt signaling modulates mechanotransduction in the epidermis to drive hair follicle regeneration	164
Structure and electron transfer pathways of an electron-bifurcating NiFe-hydrogenase	161
Predicting master transcription factors from pan-cancer expression data	161
Targeting TRPC channels for control of arthritis-induced bone erosion	160
CMOS-compatible electro-optical SRAM cavity device based on negative differential resistance	160
Memristive floating-point Fourier neural operator network for efficient scientific modeling	160
MiniXL: An open-source, large field-of-view epifluorescence miniscope enabling single-cell resolution and multi-region imaging in mice	159
An annually resolved 5700-year storm archive reveals drivers of Caribbean cyclone frequency	157
Pd/Xu-Phos-catalyzed asymmetric elimination of fully substituted enol triflates into axially chiral trisubstituted allenes	156
The synovial environment steers cartilage deterioration and regeneration	156
Unmasking of the von Willebrand A-domain surface adhesin CglB at bacterial focal adhesions mediates myxobacterial gliding motility	155
Dephosphorylation and ion binding in prokaryotic calcium transport	154
RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS	154
Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodies	153
Ocean-induced melt volume directly paces ice loss from Pine Island Glacier	153
Dynamic phase transitions dictate the size effect and activity of supported gold catalysts	152
Tree-ring stable isotopes from the European Alps reveal long-term summer drying over the Holocene	151
Evolutionary epigenomic analyses in mammalian early embryos reveal species-specific innovations and conserved principles of imprinting	148
A biopolymer hydrogel electrostatically reinforced by amino-functionalized bioactive glass for accelerated bone regeneration	148
Ag-doped non–imperfection-enabled uniform memristive neuromorphic device based on van der Waals indium phosphorus sulfide	147
Pathways to concealed gun carrying	146
Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation	144
Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity	144
Neuromuscular embodiment of feedback control elements in Drosophila flight	143
Long noncoding RNA DREAMer bridges the DREAM complex and E2f1 to regulate endoreplication in Drosophila	143
Increasing co-occurrence of fine particulate matter and ground-level ozone extremes in the western United States	142
Optimizing the timing of an end-of-outbreak declaration: Ebola virus disease in the Democratic Republic of the Congo	142
Phosphorylation of XPD drives its mitotic role independently of its DNA repair and transcription functions	141
Cpeb1 remodels cell type–specific translational program to promote fear extinction	141
Erratum for the Research Article: “Oscillation of type IV pili regulated by the circadian clock in cyanobacterium Synechococcus elongatus PCC7942” by Zhang <	141
Inflammatory responses to acute carbon monoxide poisoning and the role of plasma gelsolin	141
Autocatalytic assembly of a chimeric aminoacyl-RNA synthetase ribozyme	141
Divergent synthesis of complex withanolides enabled by a scalable route and late-stage functionalization	140
Microsecond dynamics control the HIV-1 Envelope conformation	140
Real-space investigation of polarons in hematite Fe 2 O 3	140
A closed-loop catalytic nanoreactor system on a transistor	140
Motion Hologram: Jointly optimized hologram generation and motion planning for photorealistic 3D displays via reinforcement learning	139
Erratum for the Research Article: “TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma” by Sun et al .	138
Depolarization block in olfactory sensory neurons expands the dimensionality of odor encoding	138
Considering intentional stratospheric dehydration for climate benefits	137
Liquid palladium for high-turnover carbon-carbon bond formation	137
Convergent consequences of parthenogenesis on stick insect genomes	136
Broadband photodetection of intense lasers via exciton-enhanced high-order multiphoton-absorption optoelectronics in 2D hybrid perovskite	136
Maternal chemosignals enhance infant-adult brain-to-brain synchrony	135
Diversification of the ruminant skull along an evolutionary line of least resistance	135
Daily turnover of active giant virus infection during algal blooms revealed by single-cell transcriptomics	135
Elder fish means more microplastics? Alaska pollock microplastic story in the Bering Sea	135
Quantized critical supercurrent in SrTiO 3 -based quantum point contacts	135
Symmetry disruption commits vault particles to disassembly	134
Direct observation of multiband transport in magnonic Penrose quasicrystals via broadband and phase-resolved spectroscopy	134
Pancreatic tumor microenvironmental acidosis and hypoxia transform gold nanorods into cell-penetrant particles for potent radiosensitization	134
Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition	133
Multi-stimulus perception and visualization by an intelligent liquid metal-elastomer architecture	133
Significant loophole-free test of Kochen-Specker contextuality using two species of atomic ions	133
Electrostatic nano-mask patterned 180° domain walls in a ferroelectric film	132
Spinning and corkscrewing of oceanic macroplankton revealed through in situ imaging	132
Miniature color camera via flat hybrid meta-optics	132
A molecular switch controls assembly of bacterial focal adhesions	132
Real-time observation of non-equilibrium phonon-electron energy and angular momentum flow in laser-heated nickel	132
The D614G mutation redirects SARS-CoV-2 spike to lysosomes and suppresses deleterious traits of the furin cleavage site insertion mutation	131
Phylogenetic tracing of midbrain-specific regulatory sequences suggests single origin of eubilaterian brains	130
A DNA circuit that records molecular events	130
Quantum imaging of the reconfigurable VO 2 synaptic electronics for neuromorphic computing	130
Volcanic CO 2 tracks the incubation period of basaltic paroxysms	129
Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control	129
Magnetic fields and relativistic electrons fill entire galaxy cluster	129
Experimental evidence for long-distance electrodynamic intermolecular forces	129
Mechanical tension mobilizes Lgr6 + epidermal stem cells to drive skin growth	129
1.63-billion-year-old multicellular eukaryotes from the Chuanlinggou Formation in North China	129
The super elongation complex drives transcriptional addiction in MYCN -amplified neuroblastoma	129
Clusters of lineage-specific genes are anchored by ZNF274 in repressive perinucleolar compartments	128
Dual activities of ACC synthase: Novel clues regarding the molecular evolution of ACS genes	128
Comediation of voltage gating and ion charge in MXene membrane for controllable and selective monovalent cation separation	128
The potassium transporter TaNHX2 interacts with TaGAD1 to promote drought tolerance via modulating stomatal aperture in wheat	128
Driving forces of Antarctic krill abundance	128
Dissecting abstract, modality-specific and experience-dependent coding of affect in the human brain	128

The cohesin stabilizer Sororin drives G 2 -M transition and spindle assembly in mammalian oocytes	128
Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization	128
Rise in broadly cross-reactive adaptive immunity against human β-coronaviruses in MERS-recovered patients during the COVID-19 pandemic	127
Small effect of partial melt on electrical anomalies in the asthenosphere	127
Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer	127
Observation of dynamic nuclear polarization echoes	127
Early IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a therapeutic target	126
Overexpression of the scopoletin biosynthetic pathway enhances lignocellulosic biomass processing	125
Compressing slippery surface-assembled amphiphiles for tunable haptic energy harvesters	125
Invariable resistance of conductive nanocomposite over 30% strain	124
Subcellular organization of viral particles during maturation of nucleus-forming jumbo phage	123
De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex	123
Transcriptional regulation of photoprotection in dark-to-light transition—More than just a matter of excess light energy	122
Buffering of genetic dominance by allele-specific protein complex assembly	122
Regulation of PD-L1 through direct binding of cholesterol to CRAC motifs	122
Non-adapted bacterial infection suppresses plant reproduction	121
Erratum for the Research Article: “Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell”	121
Genome wide nucleosome landscape shapes 3D chromatin organization	121
Development of xanthone derivatives as effective broad-spectrum antimicrobials: Disrupting cell wall and inhibiting DNA synthesis	120
Episodic reef growth in the Last Interglacial driven by competing influence of polar ice sheets to sea level rise	120
Modulating environmental signals to reveal mechanisms and vulnerabilities of cancer persisters	120
A two-stage mantle plume-sagduction origin of Archean continental crust revealed by water and oxygen isotopes of TTGs	120
How genomic insights into the evolutionary history of clouded leopards inform their conservation	120
Sensory-motor circuit is a therapeutic target for dystonia musculorum mice, a model of hereditary sensory and autonomic neuropathy 6	120
27-Hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior	120
Ancient genomes reveal Avar-Hungarian transformations in the 9th-10th centuries CE Carpathian Basin	119
Enhanced NF-κB activation via HIV-1 Tat-TRAF6 cross-talk	119
Quantum imaging of biological organisms through spatial and polarization entanglement	119
Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy	119
Time-resolving state-specific molecular dissociation with XUV broadband absorption spectroscopy	119
Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor–mediated synergistic antileukemic actions	118
A conserved molecular template underlies color pattern diversity in estrildid finches	118
A computational mechanism of cue-stimulus integration for pain in the brain	118
Distributed interfacing by nanoscale photodiodes enables single-neuron light activation and sensory enhancement in 3D spinal explants	117
Low-dose metformin requires brain Rap1 for its antidiabetic action	117
Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis	117
On-demand modulating afterglow color of water-soluble polymers through phosphorescence FRET for multicolor security printing	117
Analysis of sloppiness in model simulations: Unveiling parameter uncertainty when mathematical models are fitted to data	117
Inherent tendency of Synechococcus and heterotrophic bacteria for mutualism on long-term coexistence despite environmental interference	117
Rhombohedral-stacked bilayer transition metal dichalcogenides for high-performance atomically thin CMOS devices	117
Hierarchical twinning governed by defective twin boundary in metallic materials	116
Locally controllable magnetic soft actuators with reprogrammable contraction-derived motions	115
Imaging local diffusion in microstructures using NV-based pulsed field gradient NMR	115
Injectable shear-thinning hydrogels promote oligodendrocyte progenitor cell survival and remyelination in the central nervous system	114
A monolayer crystalline covalent network of polyoxometalate clusters	114
Light affects the prefrontal cortex via intrinsically photosensitive retinal ganglion cells	114
Identification of the Wnt signal peptide that directs secretion on extracellular vesicles	113
Donor HLA-DQ genetic and functional divergence affect the control of BK polyoma virus infection after kidney transplantation	113
Elucidating the characteristics and clonal evolutionary trajectory of influenza neuraminidase broadly reactive B cell	113
Cerebrospinal fluid flow extends to peripheral nerves further unifying the nervous system	113
Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation fea	113
Seeing through arthropod eyes: An AI-assisted, biomimetic approach for high-resolution, multi-task imaging	113
Schrödinger’s red pixel by quasi-bound-states-in-the-continuum	113
Engineering edgeless human skin with enhanced biomechanical properties	112
Distributed sensing along fibers for smart clothing	112
Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury	112
Early Middle Stone Age personal ornaments from Bizmoune Cave, Essaouira, Morocco	112
Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry	112
Shear shock waves mediate haptic holography via focused ultrasound	111
Dissecting the evolutionary role of the Hox gene proboscipedia in Drosophila mouthpart diversification by f	111
Role of hierarchy structure on the mechanical adaptation of self-healing hydrogels under cyclic stretching	111
Multicatalysis protocol enables direct and versatile enantioselective reductive transformations of secondary amides	111
Rising dissolved organic carbon concentrations in coastal waters of northwestern Borneo related to tropical peatland conversion	110
AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology	110
3D DNA origami pincers that multitask on giant unilamellar vesicles	110
Emergence and reconfiguration of modular structure for artificial neural networks during continual familiarity detection	109
Phyto-inspired sustainable and high-performance fabric generators via moisture absorption-evaporation cycles	109
Biodegradable electrospinning superhydrophilic nanofiber membranes for ultrafast oil-water separation	109
Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury	109
High-throughput production of kilogram-scale nanofibers by Kármán vortex solution blow spinning	109
Tailoring sub-3.3 Å ultramicropores in advanced carbon molecular sieve membranes for blue hydrogen production	109
A solid-to-solid metallic conversion electrochemistry toward 91% zinc utilization for sustainable aqueous batteries	109
LC3-associated endocytosis and the functions of Rubicon and ATG16L1	108
All eukaryotic SMC proteins induce a twist of −0.6 at each DNA loop extrusion step	108
Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis	108
Biological self-protection inspired engineering of nanomaterials to construct a robust bio-nano system for environmental applications	108
Soft robotic origami crawler	108
An artificial intelligence enabled chemical synthesis robot for exploration and optimization of nanomaterials	108
Underwater metamaterial absorber with impedance-matched composite	108
An outsized role for the Labrador Sea in the multidecadal variability of the Atlantic overturning circulation	108
An artificial sodium-selective subnanochannel	107
VARP binds SNX27 to promote endosomal supercomplex formation on membranes	107
Gender composition predicts gender bias: A meta-reanalysis of hiring discrimination audit experiments	107
Valence electron concentration as key parameter to control the fracture resistance of refractory high-entropy carbides	107
Ordered planar plating/stripping enables deep cycling zinc metal batteries	107
Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8 + T cell responses	106
Direct observations of cross-scale wave-particle energy transfer in space plasmas	106
A stretchable and strain-unperturbed pressure sensor for motion interference–free tactile monitoring on skins	106
HfZrO-based synaptic resistor circuit for a Super-Turing intelligent system	106
Spiral self-assembly of lamellar micelles into multi-shelled hollow nanospheres with unique chiral architecture	106
Atomic Sn–enabled high-utilization, large-capacity, and long-life Na anode	106
Alcaligenes faecalis corrects aberrant matrix metalloproteinase expression to promote reepithelialization of diabetic wounds	105
Anthropogenic forcing has increased the risk of longer-traveling and slower-moving large contiguous heatwaves	105
Monocytic MDSCs exhibit superior immune suppression via adenosine and depletion of adenosine improves efficacy of immunotherapy	105
Correlated x-ray fluorescence and ptychographic nano-tomography on Rembrandt’s The Night Watch reveals unknown lead “layer”	105