OOIR: Observatory of International Research

Papers

(The TQCC of Cannabis and Cannabinoid Research is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Case in Context: Acne Inversa (Hidradenitis Suppurativa)	82
Intra-Accumbal D1- But not D2-Like Dopamine Receptor Antagonism Reverses the Inhibitory Effects of Cannabidiol on Extinction and Reinstatement of Methamphetamine Seeking Behavior in Rats	52
A Double-Blind, Randomized, Placebo-Controlled Test of the Effects of Cannabidiol on Experiences of Test Anxiety Among College Students	43
Brain Penetrant, but not Peripherally Restricted, Synthetic Cannabinoid 1 Receptor Agonists Promote Morphine-Mediated Respiratory Depression	42
Increased White Matter Coherence Following Three and Six Months of Medical Cannabis Treatment	40
Cannabidiol Marketing Strategies in the United States: An Analysis of Three Prominent Companies	40
Understanding and Rebalancing: A Rapid Scoping Review of Cannabis Research Among Indigenous People	39
Typical Hits, Grams, or Joints: Evaluating Cannabis Survey Measurement Strategies for Quantifying Consumption	38
Endocannabinoid System Biomarkers in Alzheimer's Disease	37
The Endocannabinoid System as a Potential Therapeutic Target for HIV-1-Associated Neurocognitive Disorder	36
Cannabis Use and Biomarkers of Inflammation, Immune Activation, and Microbial Translocation in Persons with HIV	31
Pharmacokinetics of Oral Minor Cannabinoids in Blood and Brain	31
A Preliminary Pharmacokinetic Comparison of Δ-9 Tetrahydrocannabinol and Cannabidiol Extract Versus Oromucosal Spray in Healthy Men and Women	29
Prosocial Effects of Nonpsychotropic Cannabis sativa in Mice	29
Stakeholders' Decisions and Preferences for the Provision and Use of Medicinal Cannabis: A Scoping Review	28
Comparative Pharmacokinetic Assessment of Innovative Sublingual, Rectal and Vaporizer Cannabis Products Versus Approved Cannabis Products in Healthy Volunteers	27
Legalization of Smokable Medical Cannabis and Changes in the Dispensed Amount of Δ-9 Tetrahydrocannabinol Per Patient	27
Therapeutic Effects of Non-Euphorigenic Cannabis Extracts in Osteoarthritis	26
The Utility of THC Cutoff Levels in Blood and Saliva for Detection of Impaired Driving	26
A Scoping Review on the Medical and Recreational Use of Cannabis During the COVID-19 Pandemic	26
An Updated Analysis of Clinical Outcome Measures Across Patients From the UK Medical Cannabis Registry	26
Kinetics of CBD, Δ⁹-THC Degradation and Cannabinol Formation in Cannabis Resin at Various Temperature and pH Conditions	26
Genome-Wide Identification and Expression Profiles of bZIP Genes in Cannabis sativa L.	26
Call for Special Issue Papers: Cannabidiol	26
Letter to the Editor: Response to Dr. Mousavi’s Comments on Ogunsola et al	25

Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective	24
Shifting the Paradigm on Cannabis Safety	24
Requirements for Cannabis Product Labeling by U.S. State	23
Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner	23
The Effect of Cannabidiol for Restless Legs Syndrome/Willis-Ekbom Disease in Parkinson's Disease Patients with REM Sleep Behavior Disorder: A Post Hoc Exploratory Analysis of Phase 2/3 Clinical	23
Extending Gender- and Sex-Based Analyses in Cannabis Research: Findings from an Online Sample of Gender Diverse Young Adult Consumers	23
A Thematic Text Analysis of Cannabis Edibles Brand Names	23
Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes	22
In Silico Genome-Wide Analysis of B3 Transcription Factors in Cannabis sativa L.	22
Cannabis Use in Pregnancy and Neonatal Outcomes: A Systematic Review and Meta-Analysis	22
Cannabinoid Hyperemesis Syndrome Survey and Genomic Investigation	21
Letter to the Editor: Would Cannabidiol Be a Therapeutic Alternative to Treat Monkeypox Symptoms?	21
Cannabis and Its Permissibility Status	20
Letter to the Editor: Snoop Dogg's Announcement to “Give Up Smoke” Has Fans Reevaluating Their Own Patterns of Cannabis Use	20
The Use of Cannabis sativa L. for Pest Control: From the Ethnobotanical Knowledge to a Systematic Review of Experimental Studies	20
Cannabinoids for Substance Use Disorder Treatment: What Does the Current Evidence Say?	19
Origins ofCannabis sativain Ireland and the Concept of Celtic Hemp: An Interdisciplinary Review	19
Changes in Medical Cannabis Use After Recreational Cannabis Legalization in Canada	19
Relationship Between Recreational Cannabis Use and Helicobacter pylori Infection	18
Temporal Trends in Semen Quality, Hormone Levels, and Substance Use Among Infertile Men in Pre- and Post-Cannabis Legalization Eras in Canada	18
Solid-State Microwave Drying for Medical Cannabis Inflorescences: A Rapid and Controlled Alternative to Traditional Drying	18
Cerebrovascular Effects of Alcohol Combined with Tetrahydrocannabinol	18
Effects of Tetrahydrocannabinol and Cannabidiol on Brain-Derived Neurotrophic Factor and Tropomyosin Receptor Kinase B Expression in the Adolescent Hippocampus	17
Endocannabinoids and Stress-Related Neurospsychiatric Disorders: A Systematic Review and Meta-Analysis of Basal Concentrations and Response to Acute Psychosocial Stress	17
Cannabidiol Pretreatment Reduces Status Epilepticus and Glutamate Uptake Induced by Kainic Acid in Adult Zebrafish	17
Acknowledgment of Reviewers 2023	16
Correction to: Chronic Psychosocial Stress Causes Increased Anxiety-Like Behavior and Alters Endocannabinoid Levels in the Brain of C57Bl/6J Mice, by Bouter, et al. Cannabis and Cannabinoid Res	16
Chemistry and Biological Activities of Cannflavins of the Cannabis Plant	15
Effect of Cannabinoid 2 Receptor Modulation on the Peripheral Immune Response in Central Nervous System Injury-Induced Immunodeficiency Syndrome	15
An Approach to Biomarker Discovery of Cannabis Use Utilizing Proteomic, Metabolomic, and Lipidomic Analyses	15
Call for Special Issue Papers: Sex and Gender Differences: Focus on Cannabis and Cannabinoids	15
The Potential Paradoxical Neurocognitive Effects of Cannabis Use in Patients with Psychotic Disorders: A Critical Meta-Review of Meta-Analytical Evidence	15
Pharmacological Interaction Between Cannabidiol and Tramadol on Experimental Diabetic Neuropathic Pain: An Isobolographic Analysis	15
Cannabidiol for COVID-19 Patients with Mild to Moderate Symptoms (CANDIDATE Study): A Randomized, Double-Blind, Placebo-Controlled Clinical Trial	14
The Effect of Nabiximols on Driving Ability in Adults with Chronic Tic Disorders: Results of a Substudy Analysis of the Double-Blind, Randomized, Placebo-Controlled CANNA-TICS Trial	14
Cannabis Roots: Therapeutic, Biotechnological and Environmental Aspects	14
Complex Regional Pain Syndrome Type I: Evidence for the CB1 and CB2 Receptors Immunocontent and Beneficial Effect of Local Administration of Cannabidiol in Mice	14
Understanding Cannabis-Related Information Needs: An Analysis of Inquiries to the National Cancer Institute's Cancer Information Service	14
Cannabis Use Does Not Increase Risk of Perioperative Complications Following Primary Total Hip Arthroplasty: A Cohort-Matched Comparison	14
Absorbance-Transmittance Excitation Emission Matrix Method for Quantification of Major Cannabinoids and Corresponding Acids: A Rapid Alternative to Chromatography for Rapid Chemotype Discrimination of	13
Cannabidiol Interferes with Establishment of Δ⁹-Tetrahydrocannabinol-Induced Nausea Through a 5-HT_1A Mechanism	13
Effects of the Acute and Chronic Administration of Cannabidiol on Cognition in Humans and Animals: A Systematic Review	13
Baseline Cannabinoid Use Is Associated with Increased Sedation Requirements for Outpatient Endoscopy	13
Re: “Regular Use of Cannabis in Female Athletes Is Associated with a Reduction in Early Anaerobic Power Production” by Lisano et al.	13
Challenges of Extracting and Determining Cannabinoids in Different Matrices	13
Cannabinoid Photochemistry: An Underexplored Opportunity	13
Broad-Spectrum Antiviral Effect of Cannabidiol Against Enveloped and Nonenveloped Viruses	13
Use of Medical Cannabis in Patients with Gilles de la Tourette's Syndrome in a Real-World Setting	13
A National Survey of Marijuana Use Among U.S. Adults According to Obesity Status, 2016–2022	13
Systematic Review on Transdermal/Topical Cannabidiol Trials: A Reconsidered Way Forward	13

Assessing Health Care Providers' Knowledge of Medical Cannabis	13
A Survey Study of Individuals Using Hexahydrocannabinol Cannabis Products: Use Patterns and Perceived Effects	12
Associations of Cannabis Use, Metabolic Dysfunction-Associated Steatotic Liver Disease, and Liver Fibrosis in U.S. Adults	12
Oral Cannabis for Taxane-Induced Neuropathy: A Pilot Randomized Placebo-Controlled Study	12
Cannabinol and Sleep: Separating Fact from Fiction	12
Perinatal CBD or THC Exposure Results in Lasting Resistance to Fluoxetine in the Forced Swim Test: Reversal by Fatty Acid Amide Hydrolase Inhibition	12
Investigating the Relationship Between Cannabis Expectancies and Anxiety, Depression, and Pain Responses After Acute Flower and Edible Cannabis Use	12
Oral Cannabidiol Treatment Is Associated with an Anti-Inflammatory Gene Expression Signature in Myeloid Cells of People Living with HIV	11
Letter to the Editor: The Receptor(s) via Which Cannabidiol Affects Muscle Signaling: In Need for More Insights	11
Involvement of the Endocannabinoid System in the Control of Pain and Obesity by Exercise in Rodents: A Systematic Review	11
Behavioral Effects of Vaporized Delta-8 Tetrahydrocannabinol, Cannabidiol, and Mixtures in Male Rats	11
Δ⁹-THC and CBD in Plasma, Oral Fluid, Exhaled Breath, and Urine from 23 Patients Administered Sativex	11
Sex Differences in the Association Between Cumulative Use of Cannabis and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults Study	11
Hexahydrocannabinol on the Light Cannabis Market: The Latest “New” Entry	11
Types and Brands of Derived Psychoactive Cannabis Products: An Online Retail Assessment, 2023	11
The Effect of Route of Administration and Vehicle on the Pharmacokinetics of THC and CBD in Adult, Neonate, and Breastfed Sprague-Dawley Rats	11
Δ9-Tetrahydrocannabinol Treatment Modifies Insulin Secretion in Pancreatic Islets from Prediabetic Mice Under Hypercaloric Diet	11
Origin, Early History, Cultivation, and Characteristics of the Traditional Varieties of Moroccan Cannabis sativa L.	10
Effect of Cannabidiol on Cyclooxygenase Type 1 and 2 Expression and Function in Human Neutrophils	10
Toxicological Evaluation and Pain Assessment of Four Minor Cannabinoids Following 14-Day Oral Administration in Rats	10
The Potential of Salivary Lipid-Based Cannabis-Responsive Biomarkers to Evaluate Medical Cannabis Treatment in Children with Autism Spectrum Disorder	10
Effects of Medical Cannabis Treatment for Autistic Children on Anxiety and Restricted and Repetitive Behaviors and Interests: An Open-Label Study	10
In Memoriam of Professor Raphael Mechoulam	10
The Effects of Endogenous Cannabinoids on the Mammalian Respiratory System: A Scoping Review of Cyclooxygenase-Dependent Pathways	10
A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures	10
Potential Utility of Cannabidiol in Stress-Related Disorders	10
Cannabis Use Is Inversely Associated with Overweight and Obesity in Hepatitis B Virus-Infected Patients (ANRS CO22 Hepather Cohort)	10
Prediction and Discovery of Cannabidiol Crystal Polymorph Form 2	9
Cannabidiol Exposure During Rat Pregnancy Leads to Labyrinth-Specific Vascular Defects in the Placenta and Reduced Fetal Growth	9
The Reversal of Empathy-Induced Hypernociception in Male Mice by Intra-Amygdala Administration of Midazolam and Cannabidiol Depends on 5-HT₃ Receptors	9
Daily Cannabidiol Administration for 10 Weeks Modulates Hippocampal and Amygdalar Resting-State Functional Connectivity in Cannabis Users: A Functional Magnetic Resonance Imaging Open-Label Clinical T	9
Running High: Cannabis Users' Subjective Experience of Exercise During Legal Market Cannabis Use Versus No Use in a Naturalistic Setting	9
Risks of Cannabinoid Exposure on Birth Outcomes: A Systematic Review	9
A Network Pharmacology Approach to Identify Potential Molecular Targets for Cannabidiol's Anti-Inflammatory Activity	9
Cannabidiol Enhances the Anticancer Activity of Etoposide on Prostate Cancer Cells	9
Letter to the Editor: Cannabis as a Solution to the Opioid Crisis: Is the Cart Before the Horse Again?	9
A Randomized, Triple-Blind, Comparator-Controlled Parallel Study Investigating the Pharmacokinetics of Cannabidiol and Tetrahydrocannabinol in a Novel Delivery System, Solutech, in Association with Ca	9
Preliminary Eye-Tracking Data as a Nonintrusive Marker for Blood Δ-9-Tetrahydrocannabinol Concentration and Drugged Driving	9
Chemistry, Crystal Structure, and In Vitro Receptor Binding of Δ10-THC Isomers	9
Cannabis-Responsive Biomarkers: A Pharmacometabolomics-Based Application to Evaluate the Impact of Medical Cannabis Treatment on Children with Autism Spectrum Disorder	8
Cannabinoids in Treating Parkinson's Disease Symptoms: A Systematic Review of Clinical Studies	8
Effectiveness and Safety of Cannabinoids as an Add-On Therapy in the Treatment of Resistant Spasticity in Multiple Sclerosis: A Systematic Review	8
Effects of High-Potency Cannabis on Psychomotor Performance in Frequent Cannabis Users	8
The Relationship Between Circulating Endogenous Cannabinoids and the Effects of Smoked Cannabis	8
Symptoms and Extraintestinal Manifestations in Active Cannabis Users with Inflammatory Bowel Disease	8
Association Between Medical Marijuana Cardholder Status and Antiemetic Overuse	8
Electrocardiographic Markers of Arrhythmogenic Risk in Synthetic Cannabinoids Users	8
Comparing Cannabis Use Motivations and Dependence Across Regular Cannabis Users Who Have or Have Not Recently Used Psilocybin	8
Clinician Attitudes, Training, and Beliefs About Cannabis: An Interprofessional Assessment	8
Does the Quantification of Δ9-Tetrahydrocannabinolic Acid A in Serum/Plasma Provide Any Additional Information About Consumption Pattern from Drivers Under the Influence of Cannabis?	8
Workplace Cannabis Policies: A Moving Target	8
The Cannabis-Dependent Relationship Between Methadone Treatment Dose and Illicit Opioid Use in a Community-Based Cohort of People Who Use Drugs	8
Licensed Medical Cannabis Use in Gilles de la Tourette Syndrome: A Retrospective Long-term Follow-Up	8
Long-Term Frequent Cannabis Use and Related Serum Cannabinoid Levels Are Not Associated with Kidney Dysfunction	8
Effects of Chronic, Low-Dose Cannabinoids, Cannabidiol, Delta-9-Tetrahydrocannabinol and a Combination of Both, on Amyloid Pathology in the 5xFAD Mouse Model of Alzheimer's Disease	8
Evaluating the Role of the Endocannabinoid System in Axon Guidance: A Literature Review	8
Sexually Dimorphic Adolescent Trajectories of Prefrontal Endocannabinoid Synaptic Plasticity Equalize in Adulthood, Reflected by Endocannabinoid System Gene Expression	8