OOIR: Observatory of International Research

Papers

(The H4-Index of JCI Insight is 54. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Ataxia and cerebellar hypoexcitability in a mouse model of SCN1B-linked Dravet syndrome	225
A double-edged sword: iron regulation in alveolar lung epithelial repair	201
Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish	135
Intranodal expansion of follicular T helper cells in patients with multiple sclerosis	133
Health outcomes after national acute sleep deprivation events among the American public	131
Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue	113
Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease	105
Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule to increase NaCl cotransporter	102
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion	99
Interferon-dependent signaling is critical for viral clearance in airway neutrophils	92
Key patient demographics shape innate immune topography in noncritical hypoxic COVID-19 pneumonia	86
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation	85
LMAN1 serves as a cargo receptor for thrombopoietin	83
Constitutive deletion of the obscurin-Ig58/59 domains induces atrial remodeling and Ca2+-based arrhythmogenesis	81
Autosomal-dominant macular dystrophy linked to a chromosome 17 tandem duplication	74
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models	74
Urine proteomic signatures of kidney function decline after hospitalization	73
Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction	73
Regulation of selective class switching provides long-term therapeutic benefits for hay fever	73
Multicomponent parenteral lipid emulsions do not prevent liver injury in neonatal pigs with obstructive cholestasis	71
Dysregulated immunologic landscape of the early host response in melioidosis	70
The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury	69
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells	69
Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity	69
Pregnancy dedifferentiates memory CD8+ T cells into hypofunctional cells with exhaustion-enriched programs	66

Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV	65
Chemotherapy-induced reactive myelopoiesis promotes expansion of immunosuppressive neutrophil-like monocytes in mice and humans	64
Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice	64
Irx1 mechanisms for oral epithelial basal stem cell plasticity during reepithelialization after injury	64
Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy	63
De novo variant in RING finger protein 213 causes systemic vasculopathy	62
Characterization of anticancer therapy–induced microvascular dysfunction in patients with breast cancer supports targeted intervention	62
Hypoxia-activated prodrug and antiangiogenic therapies cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration	61
Th2 skewing in patients with disseminated coccidioidomycosis	61
Development of a humanized mouse model with functional human materno-fetal interface immunity	61
Pharmacological induction of MHC-I expression in tumor cells revitalizes T cell antitumor immunity	61
From improvised to intentional: re-imagining the physician-scientist career path	60
AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival	60
Programmed cycle-induced endometrial perturbations do not independently influence angiogenic imbalance or hypertensive disorders in pregnancy	59
Benchmarking urinary cell transcriptomes for noninvasive differentiation of BK polyomavirus–associated nephropathy from T cell–mediated rejection	59
CNS-dominant human FMRP isoform rescues seizures, fear, and sleep abnormalities in Fmr1-KO mice	58
CD4+ and CD8+ T cells are not the main driver of Lassa fever pathogenesis in macaques	58
Dynamic remodeling of portal vessels by Clec4g+ endothelial cells in liver growth and homeostasis	57
Endothelial cell glycogen synthase kinase 3β promotes lipotoxic endotheliopathy and liver inflammation in MASH	57
Allergen induces pulmonary neuroendocrine cell hyperplasia in a model of asthma	57
PPMO therapy for dysferlinopathy induces pseudoexon skipping and restoration of functional protein	56
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate	56
UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation	55
Effects of SIPA1L1 on trabecular meshwork extracellular matrix protein accumulation and cellular phagocytosis in POAG	55
Slick K+ channels contribute to cardiac remodeling, fibrosis, and dysfunction in postinfarction hearts	55
Macrophage ferritin heavy chain/α-synuclein regulatory axis modulates ferroptosis during kidney injury	55
Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition	55
Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk	54
Dipeptidase-1–knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer	54
BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia	54
CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis	54
Somatic mutations reveal hyperactive Notch signaling in prurigo nodularis	54