OOIR: Observatory of International Research

Papers

(The H4-Index of JCI Insight is 52. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Allergen induces pulmonary neuroendocrine cell hyperplasia in a model of asthma	187
A hypomorphic Mpi mutation unlocks an in vivo tool for studying global N-glycosylation deficiency	144
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models	133
Fibrotic lung disease inhibits immune responses to staphylococcal pneumonia via impaired neutrophil and macrophage function	124
Longitudinal analysis of T cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection	119
Combinatorial transcription factor profiles predict mature and functional human islet α and β cells	113
Recurrent moderate hypoglycemia accelerates the progression of Alzheimer’s disease through impairment of the TRPC6/GLUT3 pathway	108
Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis	96
Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice	95
Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas	95
A dominant pathogenic MEFV mutation causes atypical pyrin-associated periodic syndromes	92
Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection	86
11C-Para-aminobenzoic acid PET imaging of S. aureus and MRSA infection in preclinical models and humans	86
EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice	85
Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV	78
AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival	78
LMAN1 serves as a cargo receptor for thrombopoietin	77
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses	77
Effects of SIPA1L1 on trabecular meshwork extracellular matrix protein accumulation and cellular phagocytosis in POAG	76
The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury	76
CNS-dominant human FMRP isoform rescues seizures, fear, and sleep abnormalities in Fmr1-KO mice	73
Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice	73
Bariatric surgery improves postprandial VLDL kinetics and restores insulin-mediated regulation of hepatic VLDL production	72
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation	70
Interferon-dependent signaling is critical for viral clearance in airway neutrophils	67

Hypoxia-activated prodrug and antiangiogenic therapies cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration	66
Dipeptidase-1–knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer	65
Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction	64
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate	64
De novo variant in RING finger protein 213 causes systemic vasculopathy	63
Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk	63
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion	62
The timing of auditory sensory deficits in Norrie disease has implications for therapeutic intervention	62
UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation	61
Nociceptor neurons promote IgE class switch in B cells	61
Coimmunomodulation of tumor and tumor-draining lymph nodes during in situ vaccination promotes antitumor immunity	60
Key patient demographics shape innate immune topography in noncritical hypoxic COVID-19 pneumonia	60
Multicomponent parenteral lipid emulsions do not prevent liver injury in neonatal pigs with obstructive cholestasis	60
Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes	59
Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule to increase NaCl cotransporter	59
Development of a humanized mouse model with functional human materno-fetal interface immunity	58
Pharmacological induction of MHC-I expression in tumor cells revitalizes T cell antitumor immunity	58
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells	56
Dysregulated immunologic landscape of the early host response in melioidosis	55
CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis	54
Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease	54
Autosomal-dominant macular dystrophy linked to a chromosome 17 tandem duplication	54
Longitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians	54
Irx1 mechanisms for oral epithelial basal stem cell plasticity during reepithelialization after injury	54
Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity	53
Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy	52
Constitutive deletion of the obscurin-Ig58/59 domains induces atrial remodeling and Ca2+-based arrhythmogenesis	52
Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV	52