OOIR: Observatory of International Research

Papers

(The H4-Index of JCI Insight is 52. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Allergen induces pulmonary neuroendocrine cell hyperplasia in a model of asthma	199
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models	151
Development of a humanized mouse model with functional human materno-fetal interface immunity	136
Irx1 mechanisms for oral epithelial basal stem cell plasticity during reepithelialization after injury	130
Dipeptidase-1–knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer	126
Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas	115
A dominant pathogenic MEFV mutation causes atypical pyrin-associated periodic syndromes	114
Coimmunomodulation of tumor and tumor-draining lymph nodes during in situ vaccination promotes antitumor immunity	98
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses	97
The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury	96
Effects of SIPA1L1 on trabecular meshwork extracellular matrix protein accumulation and cellular phagocytosis in POAG	93
Pharmacological induction of MHC-I expression in tumor cells revitalizes T cell antitumor immunity	90
Dysregulated immunologic landscape of the early host response in melioidosis	89
Longitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians	87
Autosomal-dominant macular dystrophy linked to a chromosome 17 tandem duplication	80
Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease	80
Constitutive deletion of the obscurin-Ig58/59 domains induces atrial remodeling and Ca2+-based arrhythmogenesis	79
Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity	79
Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice	78
11C-Para-aminobenzoic acid PET imaging of S. aureus and MRSA infection in preclinical models and humans	78
EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice	77
AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival	74
LMAN1 serves as a cargo receptor for thrombopoietin	72
De novo variant in RING finger protein 213 causes systemic vasculopathy	70
Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction	70

Type I interferons and TGF-β cooperate to induce liver fibrosis during HIV-1 infection under antiretroviral therapy	67
Key patient demographics shape innate immune topography in noncritical hypoxic COVID-19 pneumonia	67
Epac1–/– and Epac2–/– mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation	66
Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish	66
Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy	64
Myocardial ATP depletion detected noninvasively predicts sudden cardiac death risk in patients with heart failure	64
BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia	63
CNS-dominant human FMRP isoform rescues seizures, fear, and sleep abnormalities in Fmr1-KO mice	62
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation	62
Pregnancy dedifferentiates memory CD8+ T cells into hypofunctional cells with exhaustion-enriched programs	62
Bariatric surgery improves postprandial VLDL kinetics and restores insulin-mediated regulation of hepatic VLDL production	61
Interferon-dependent signaling is critical for viral clearance in airway neutrophils	60
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis	60
Hypoxia-activated prodrug and antiangiogenic therapies cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration	60
A hypomorphic Mpi mutation unlocks an in vivo tool for studying global N-glycosylation deficiency	59
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells	59
Fibrotic lung disease inhibits immune responses to staphylococcal pneumonia via impaired neutrophil and macrophage function	58
Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV	58
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate	56
Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis	55
Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV	55
Urine Proteomic Signatures of Kidney Function Decline after Hospitalization	55
Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule to increase NaCl cotransporter	55
Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition	54
Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection	54
The timing of auditory sensory deficits in Norrie disease has implications for therapeutic intervention	53
Longitudinal analysis of T cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection	52
T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade	52