OOIR: Observatory of International Research

Papers

(The H4-Index of JCI Insight is 51. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation	217
A hypomorphic Mpi mutation unlocks an in vivo tool for studying global N-glycosylation deficiency	144
Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV	140
BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia	133
AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival	108
Multicomponent parenteral lipid emulsions do not prevent liver injury in neonatal pigs with obstructive cholestasis	105
Bariatric surgery improves postprandial VLDL kinetics and restores insulin-mediated regulation of hepatic VLDL production	101
Characterization of anti-cancer therapy-induced microvascular dysfunction in breast cancer patients with proof-of-concept of targeted intervention	101
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate	96
Type I interferons and TGF-β cooperate to induce liver fibrosis during HIV-1 infection under antiretroviral therapy	88
Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice	86
A dominant pathogenic MEFV mutation causes atypical pyrin-associated periodic syndromes	83
Myocardial ATP depletion detected noninvasively predicts sudden cardiac death risk in patients with heart failure	82
Pharmacological induction of MHC-I expression in tumor cells revitalizes T cell antitumor immunity	81
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells	80
Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy	79
Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas	77
The timing of auditory sensory deficits in Norrie disease has implications for therapeutic intervention	75
Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis	73
CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis	71
Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction	70
Dipeptidase-1–knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer	70
Irx1 mechanisms for oral epithelial basal stem cell plasticity during reepithelialization after injury	70
The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury	69
De novo variant in RING finger protein 213 causes systemic vasculopathy	69

Effects of SIPA1L1 on trabecular meshwork extracellular matrix protein accumulation and cellular phagocytosis in POAG	67
Longitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians	64
Autosomal-dominant macular dystrophy linked to a chromosome 17 tandem duplication	63
Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity	62
Constitutive deletion of the obscurin-Ig58/59 domains induces atrial remodeling and Ca2+-based arrhythmogenesis	62
11C-Para-aminobenzoic acid PET imaging of S. aureus and MRSA infection in preclinical models and humans	61
Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice	61
LMAN1 serves as a cargo receptor for thrombopoietin	61
Development of a humanized mouse model with functional human materno-fetal interface immunity	60
Urine proteomic signatures of kidney function decline after hospitalization	59
Epac1–/– and Epac2–/– mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation	58
CD4+ and CD8+ T-cells are not the main driver of Lassa fever pathogenesis in macaques	58
Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease	57
Interferon-dependent signaling is critical for viral clearance in airway neutrophils	57
Nociceptor neurons promote IgE class switch in B cells	57
Allergen induces pulmonary neuroendocrine cell hyperplasia in a model of asthma	56
Hypoxia-activated prodrug and antiangiogenic therapies cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration	56
Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection	55
EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice	55
Pregnancy dedifferentiates memory CD8+ T cells into hypofunctional cells with exhaustion-enriched programs	54
Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk	53
T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade	53
Recurrent moderate hypoglycemia accelerates the progression of Alzheimer’s disease through impairment of the TRPC6/GLUT3 pathway	52
Longitudinal analysis of T cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection	52
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models	51
Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish	51
Fibrotic lung disease inhibits immune responses to staphylococcal pneumonia via impaired neutrophil and macrophage function	51
Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV	51
Intranodal expansion of follicular T helper cells in patients with multiple sclerosis	51