OOIR: Observatory of International Research

Papers

(The H4-Index of JCI Insight is 51. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
A hypomorphic Mpi mutation unlocks an in vivo tool for studying global N-glycosylation deficiency	162
Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV	152
Recurrent moderate hypoglycemia accelerates the progression of Alzheimer’s disease through impairment of the TRPC6/GLUT3 pathway	146
Intranodal expansion of follicular T helper cells in patients with multiple sclerosis	118
Fibrotic lung disease inhibits immune responses to staphylococcal pneumonia via impaired neutrophil and macrophage function	111
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models	111
Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish	108
AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival	102
Multicomponent parenteral lipid emulsions do not prevent liver injury in neonatal pigs with obstructive cholestasis	100
Bariatric surgery improves postprandial VLDL kinetics and restores insulin-mediated regulation of hepatic VLDL production	88
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate	84
Irx1 mechanisms for oral epithelial basal stem cell plasticity during reepithelialization after injury	83
Dipeptidase-1–knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer	82
Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction	81
De novo variant in RING finger protein 213 causes systemic vasculopathy	79
The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury	76
Effects of SIPA1L1 on trabecular meshwork extracellular matrix protein accumulation and cellular phagocytosis in POAG	73
Longitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians	73
Autosomal-dominant macular dystrophy linked to a chromosome 17 tandem duplication	73
Constitutive deletion of the obscurin-Ig58/59 domains induces atrial remodeling and Ca2+-based arrhythmogenesis	72
Epac1–/– and Epac2–/– mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation	72
Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity	70
Interferon-dependent signaling is critical for viral clearance in airway neutrophils	70
Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis	69
T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade	69

Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV	69
Allergen induces pulmonary neuroendocrine cell hyperplasia in a model of asthma	67
Hypoxia-activated prodrug and antiangiogenic therapies cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration	66
EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice	65
Key patient demographics shape innate immune topography in noncritical hypoxic COVID-19 pneumonia	61
Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas	61
Type I interferons and TGF-β cooperate to induce liver fibrosis during HIV-1 infection under antiretroviral therapy	61
LMAN1 serves as a cargo receptor for thrombopoietin	61
Pregnancy dedifferentiates memory CD8+ T cells into hypofunctional cells with exhaustion-enriched programs	60
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses	60
Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection	60
Myocardial ATP depletion detected noninvasively predicts sudden cardiac death risk in patients with heart failure	60
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells	60
CD4+ and CD8+ T cells are not the main driver of Lassa fever pathogenesis in macaques	58
Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule to increase NaCl cotransporter	58
CNS-dominant human FMRP isoform rescues seizures, fear, and sleep abnormalities in Fmr1-KO mice	56
UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation	56
BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia	55
11C-Para-aminobenzoic acid PET imaging of S. aureus and MRSA infection in preclinical models and humans	54
Coimmunomodulation of tumor and tumor-draining lymph nodes during in situ vaccination promotes antitumor immunity	54
Ataxia and cerebellar hypoexcitability in a mouse model of SCN1B-linked Dravet syndrome	53
Pharmacological induction of MHC-I expression in tumor cells revitalizes T cell antitumor immunity	53
Urine proteomic signatures of kidney function decline after hospitalization	53
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation	53
Regulation of selective class switching provides long-term therapeutic benefits for hay fever	53
Health outcomes after national acute sleep deprivation events among the American public	52
Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice	51
Characterization of anticancer therapy–induced microvascular dysfunction in patients with breast cancer supports targeted intervention	51
Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease	51
Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy	51