JCI Insight

Papers
(The TQCC of JCI Insight is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
Reverse electrical remodeling in rats with heart failure and preserved ejection fraction152
Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation driven colorectal cancers134
Unique T cell signatures associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort130
N-glycosylation in the SERPIN domain of the C1-esterase inhibitor in hereditary angioedema125
Constitutive deletion of the obscurin-Ig58/59 domains induces atrial remodeling and Ca2+-based arrhythmogenesis122
Prothrombin prevents fatal T cell–dependent anemia during chronic virus infection of mice115
The impact of remdesivir on SARS-CoV-2 evolution in vivo108
T follicular regulatory cells in food allergy promote IgE via IL-4107
Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction102
A modeling-based approach to optimize COVID-19 vaccine dosing schedules for improved protection101
Hepatic HIF2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency91
IFN-signaling gene expression as a diagnostic biomarker for monogenic interferonopathies89
Fibrotic lung disease inhibits immune responses to staphylococcal pneumonia via impaired neutrophil and macrophage function88
SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside84
Immunopathogenesis of hidradenitis suppurativa and response to anti–TNF-α therapy83
Myosin folding boosts solubility in cardiac muscle sarcomeres82
Distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy-sensitive than papillary thyroid cancer80
Obesity modulates NK cell activity via LDL and DUSP1 signaling for populations with adverse social determinants78
Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV75
Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice73
Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling73
Dysregulated immunologic landscape of the early host response in melioidosis72
T cell responses and clinical symptoms among infants with congenital cytomegalovirus infection72
Molecular subtyping improves breast cancer diagnosis in the Copenhagen Breast Cancer Genomics Study71
Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma70
Activation of autoreactive lymphocytes in the lung by STING gain-of-function mutation expressing radioresistant cells69
Neuronal SLC39A8 deficiency impairs cerebellar development by altering manganese homeostasis68
Development of a humanized mouse model with functional human materno-fetal interface immunity68
Diurnal rhythms in varicella vaccine effectiveness68
Indoleamine-2,3-dioxygenase inhibition improves immunity and is safe for concurrent use with cART during Mtb/SIV coinfection66
Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection66
YY1 regulation by miR-124-3p promotes Th17 cell pathogenicity through interaction with T-bet in rheumatoid arthritis66
Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells65
Adaptive immune responses in vaccinated patients with symptomatic SARS-CoV-2 Alpha infection64
Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice64
Cell differentiation is disrupted by MYO5B loss through Wnt/Notch imbalance63
Abortion rights are health care rights62
TAp63, a methotrexate target in CD4+ T cells, suppresses Foxp3 expression and exacerbates autoimmune arthritis61
Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency60
miR–9-5p regulates immunometabolic and epigenetic pathways in β-glucan–trained immunity via IDH3α60
Pivotal roles for cancer cell–intrinsic mPGES-1 and autocrine EP4 signaling in suppressing antitumor immunity59
Placental mTOR complex 1 regulates fetal programming of obesity and insulin resistance in mice59
Endothelial cell–specific LAT1 ablation normalizes tumor vasculature59
Fibroblast-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis59
Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration58
EZH2 deletion does not affect acinar regeneration but restricts progression to pancreatic cancer in mice58
(Pro)renin receptor signaling in hypothalamic tyrosine hydroxylase neurons is required for obesity-associated glucose metabolic impairment58
Tumor-infiltrating exhausted CD8+ T cells dictate reduced survival in premenopausal estrogen receptor–positive breast cancer57
Nucleolin promotes angiogenesis and endothelial metabolism along the oncofetal axis in the human brain vasculature57
Gaps between college and starting an MD-PhD program are adding years to physician-scientist training time56
Interferon-dependent signaling is critical for viral clearance in airway neutrophils56
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation55
Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation53
Recurrent moderate hypoglycemia accelerates the progression of Alzheimer’s disease through impairment of the TRPC6/GLUT3 pathway52
NK cells contribute to reovirus-induced IFN responses and loss of tolerance to dietary antigen52
Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling51
Antibody-mediated depletion of CCR10+ EphA3+ cells ameliorates fibrosis in IPF51
Circadian transcriptome of pancreatic adenocarcinoma unravels chronotherapeutic targets50
CRISPR screening identifies BET and mTOR inhibitor synergy in cholangiocarcinoma through serine glycine one carbon50
Frataxin deficiency lowers lean mass and triggers the integrated stress response in skeletal muscle50
Comparative study in estrogen-depleted mice identifies skeletal and osteocyte transcriptomic responses to abaloparatide and teriparatide50
Polarized localization of phosphatidylserine in the endothelium regulates Kir2.150
Treg suppression of immunity within inflamed allogeneic grafts50
Spatiotemporal regulation of human IFN-ε and innate immunity in the female reproductive tract49
HIV-1 latency reversal and immune enhancing activity of IL-15 is not influenced by sex hormones49
Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine49
Type 2 innate immunity promotes the development of pulmonary fibrosis in Hermansky-Pudlak syndrome48
Loss of voltage-gated hydrogen channel 1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T cells48
Adipose triglyceride lipase–mediated lipid catabolism is essential for bronchiolar regeneration48
EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice47
Knockdown of ketohexokinase versus inhibition of its kinase activity exert divergent effects on fructose metabolism46
VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system45
Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort45
IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function45
Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas44
Age-related dysregulation of intestinal epithelium fucosylation is linked to an increased risk of colon cancer44
Disruption of mitochondrial electron transport impairs urinary concentration via AMPK-dependent suppression of aquaporin 244
BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia44
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models44
Protective role of tissue-resident Tregs in a murine model of beryllium-induced disease43
Gene coexpression networks reveal a broad role for lncRNAs in inflammatory bowel disease43
Reversal of ciliary mechanisms of disassembly rescues olfactory dysfunction in ciliopathies43
CETP inhibition enhances monocyte activation and bacterial clearance and reduces streptococcus pneumonia–associated mortality in mice43
NK cell subsets define sustained remission in rheumatoid arthritis43
Transient inhibition of sodium-glucose cotransporter 2 after ischemia/reperfusion injury ameliorates chronic kidney disease42
SFTPB in serum extracellular vesicles as a biomarker of progressive pulmonary fibrosis42
Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus42
Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice42
AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival41
Analysis of CNS autoimmunity in genetically diverse mice reveals unique phenotypes and mechanisms41
A brief morning rest period benefits cardiac repair in pressure overload hypertrophy and postmyocardial infarction41
A pathogenic in-frame deletion-insertion variant in BEST1 phenocopies Stargardt disease41
Cytomegalovirus immunity in high-risk liver transplant recipients following preemptive antiviral therapy versus prophylaxis41
GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion–positive rhabdomyosarcoma41
Transcriptome and DNA methylome analyses reveal underlying mechanisms for the racial disparity in uterine fibroids41
Missense variants in CMS22 patients reveal that PREPL has both enzymatic and nonenzymatic functions41
Immune perturbation following SHIV infection is greater in newborn macaques than in infants41
Long noncoding RNA uc.230/CUG-binding protein 1 axis sustains intestinal epithelial homeostasis and response to tissue injury41
Single-cell transcriptome mapping identifies a local, innate B cell population driving chronic rejection after lung transplantation41
Thy-1 plays a pathogenic role and is a potential biomarker for skin fibrosis in scleroderma40
An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus40
Spatial metabolomics reveals upregulation of several pyrophosphate-producing pathways in cortical bone of Hyp mice40
MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance40
The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir40
Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis40
A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasis40
Prevention of guanylyl cyclase–B dephosphorylation rescues achondroplastic dwarfism40
Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature40
Association of immune cell subsets with cardiac mechanics in the Multi-Ethnic Study of Atherosclerosis39
Natural mucosal barriers and COVID-19 in children39
Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors39
Identification of antigen-specific TCR sequences based on biological and statistical enrichment in unselected individuals39
Cell-autonomous retinoic acid receptor signaling has stage-specific effects on mouse enteric nervous system39
The m6A methyltransferase METTL16 negatively regulates MCP1 expression in mesenchymal stem cells during monocyte recruitment38
Anti-ceramide single-chain variable fragment mitigates radiation GI syndrome mortality independent of DNA repair38
Establishment of a reproducible and minimally invasive ischemic stroke model in swine38
CC16 augmentation reduces exaggerated COPD-like disease in Cc16-deficient mice38
Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates through cleaving TFIIA38
Early defects in mucopolysaccharidosis type IIIC disrupt excitatory synaptic transmission38
Molecular profiling identifies distinct subtypes across TP53 mutant tumors38
CYB5R3 in type II alveolar epithelial cells protects against lung fibrosis by suppressing TGF-β1 signaling38
Mechanism and intervention of murine transfusion-related acute lung injury caused by anti-CD36 antibodies38
Increased clonal hematopoiesis involving DNA damage response genes in patients undergoing lung transplantation38
CD163+ macrophages restrain vascular calcification, promoting the development of high-risk plaque38
Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension37
The schedule of ATR inhibitor AZD6738 can potentiate or abolish antitumor immune responses to radiotherapy37
Short- and long-term T cell and antibody responses following dexamethasone treatment in COVID-1937
The miR-182-5p/FGF21/acetylcholine axis mediates the crosstalk between adipocytes and macrophages to promote beige fat thermogenesis37
Collectin-11 promotes cancer cell proliferation and tumor growth37
Effector Vγ9Vδ2 T cell response to congenital Toxoplasma gondii infection37
CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy36
Epithelial microRNA-206 targets CD39/extracellular ATP to upregulate airway IL-25 and TSLP in type 2-high asthma36
Multiomics of Bohring-Opitz syndrome truncating ASXL1 mutations identify canonical and noncanonical Wnt signaling dysregulation36
PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39+γδ Treg polarization36
T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade36
Serum circulating proteins from pediatric patients with dilated cardiomyopathy cause pathologic remodeling and cardiomyocyte stiffness36
HPV transcript expression affects cervical cancer response to chemoradiation36
Mitochondrial β-oxidation of adipose-derived fatty acids by osteoblasts fuels parathyroid hormone–induced bone formation36
An ELF4 hypomorphic variant results in NK cell deficiency35
Role of c-Met/β1 integrin complex in the metastatic cascade in breast cancer35
Augmentation of CD47/SIRPα signaling protects cones in genetic models of retinal degeneration35
The determinants of complication trajectories in American Indians with type 2 diabetes35
Coreceptor therapy has distinct short- and long-term tolerogenic effects intrinsic to autoreactive effector T cells35
The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2–infected patients by sex and age35
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis35
Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation34
Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate34
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate34
Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-234
MEX3B inhibits collagen production in eosinophilic nasal polyps by downregulating epithelial cell TGFBR3 mRNA stability34
FXYD2 antisense oligonucleotide provides an efficient approach for long-lasting relief of chronic peripheral pain34
IgV somatic mutation of human anti–SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity34
LMAN1 serves as a cargo receptor for thrombopoietin33
Longitudinal analysis of memory Tfh cells and antibody response following CoronaVac vaccination33
Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility33
AAV-mediated delivery of secreted acid α-glucosidase with enhanced uptake corrects neuromuscular pathology in Pompe mice33
Single-cell profiling reveals inflammatory polarization of human carotid versus femoral plaque leukocytes33
Hypochondroplasia gain-of-function mutation in FGFR3 causes defective bone mineralization in mice33
miR-122 promotes virus-induced lung disease by targeting SOCS133
Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch repair–deficient colorectal cancer tissue33
Bariatric surgery improves postprandial VLDL kinetics and restores insulin-mediated regulation of hepatic VLDL production32
ACOT1 deficiency attenuates high-fat diet–induced fat mass gain by increasing energy expenditure32
Deletion of AMPK minimizes graft-versus-host disease through an early impact on effector donor T cells32
β-Catenin signaling in alveolar macrophages enhances lung metastasis through a TNF-dependent mechanism32
p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia32
A Syx-RhoA-Dia1 signaling axis regulates cell cycle progression, DNA damage, and therapy resistance in glioblastoma31
PD-1 blockade counteracts post–COVID-19 immune abnormalities and stimulates the anti–SARS-CoV-2 immune response31
Sodium in the dermis colocates to glycosaminoglycan scaffold, with diminishment in type 2 diabetes mellitus31
Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism31
Key patient demographics shape innate immune topography in noncritical hypoxic COVID-19 pneumonia31
JAK-STAT activation contributes to cytotoxic T cell–mediated basal cell death in human chronic lung allograft dysfunction31
UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation31
Hypoxic vasodilatory defect and pulmonary hypertension in mice lacking hemoglobin β-cysteine93 S-nitrosylation31
Epac1–/– and Epac2–/– mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation31
Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging31
Identifying the temporal electrophysiological and molecular changes that contribute to TSC-associated epileptogenesis31
B cell–intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice30
PRR11 promotes ccRCC tumorigenesis by regulating E2F1 stability30
The MIF promoter SNP rs755622 is associated with immune activation in glioblastoma30
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion30
Differential localization and limited cytotoxic potential of duodenal CD8+ T cells30
Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice30
Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes30
Prospective assessment of catheter-associated bacteriuria clinical presentation, epidemiology, and colonization dynamics in nursing home residents30
Collision tumors revealed by prospectively assessing subtype-defining molecular alterations in 904 individual prostate cancer foci30
Monoclonal antibody targeting the conserved region of the SARS-CoV-2 spike protein to overcome viral variants30
The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer30
Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence30
The effect of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes30
Hematopoietic stem cell–derived Tregs are essential for maintaining favorable B cell lymphopoiesis following posttransplant cyclophosphamide30
Failure to breathe persists without air hunger or alarm following amygdala seizures30
Super-resolution microscopy reveals photoreceptor-specific subciliary location and function of ciliopathy-associated protein CEP29030
CD138 expression is a molecular signature but not a developmental requirement for RORγt+ NKT17 cells30
H2Bub1 loss is an early contributor to clear cell ovarian cancer progression30
Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition30
C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy29
CPVL promotes glioma progression via STAT1 pathway inhibition through interactions with the BTK/p300 axis29
Heteroplasmic and homoplasmic m.616T>C in mitochondria tRNAPhe promote isolated chronic kidney disease and hyperuricemia29
SETD1A drives stemness by reprogramming the epigenetic landscape in hepatocellular carcinoma stem cells29
PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia29
CNS-dominant human FMRP isoform rescues seizures, fear, and sleep abnormalities in Fmr1-KO mice29
Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR229
RAG1 splicing mutation causes enhanced B cell differentiation and autoantibody production29
Sociodemographic factors and research experience impact MD-PhD program acceptance29
Myocardial ATP depletion detected noninvasively predicts sudden cardiac death risk in patients with heart failure29
Circulating autoreactive proteinase 3+ B cells and tolerance checkpoints in ANCA-associated vasculitis29
ADCC-activating antibodies correlate with decreased risk of congenital human cytomegalovirus transmission29
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease29
Immune landscape of a genetically engineered murine model of glioma compared with human glioma29
Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G29
Hypoxia-activated prodrug and antiangiogenic therapies cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration29
An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinases28
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells28
Differential CXCR4 expression on hematopoietic progenitor cells versus stem cells directs homing and engraftment28
OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma28
Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer28
Type I interferons and TGF-β cooperate to induce liver fibrosis during HIV-1 infection under antiretroviral therapy28
Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancer28
Aiolos promotes CXCR3 expression on Th1 cells via positive regulation of IFN-γ/STAT1 signaling28
The unfolded protein response links ER stress to cancer-associated thrombosis28
Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish28
Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in mice28
Immunogenetics associated with severe coccidioidomycosis28
Coimmunomodulation of tumor and tumor-draining lymph nodes during in situ vaccination promotes antitumor immunity28
Gene therapy of Csf2ra deficiency in mouse fetal monocyte precursors restores alveolar macrophage development and function28
The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury27
miR–9-5p regulates immunometabolic and epigenetic pathways in β-glucan–trained immunity via IDH3α27
SARS-CoV-2 ORF8 drives osteoclastogenesis in preexisting immune-mediated inflammatory diseases27
Pharmacological induction of MHC-I expression in tumor cells revitalizes T cell antitumor immunity27
Semicircular canal drug delivery safely targets the inner ear perilymphatic space27
Role of hepatic PKCβ in nutritional regulation of hepatic glycogen synthesis27
The financial impact of MD-PhD training compared with MD training for academic physicians27
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses27
Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy27
Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown27
Irx1 mechanisms for oral epithelial basal stem cell plasticity during reepithelialization after injury27
Protein biomarker signature in patients with spinal and bulbar muscular atrophy27
Fasting substrates predict chronic kidney disease progression in CREDENCE trial patients with type 2 diabetes27
Enhancing the clinical value of serum neurofilament light chain measurement27
Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice27
Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids26
Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms26
Heterogeneity in the effect of marked weight loss on metabolic function in women with obesity26
Involvement of lncRNA MIR205HG in idiopathic pulmonary fibrosis and IL-33 regulation via Alu elements26
A surgical method for continuous intraportal infusion of gut microbial metabolites in mice26
Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling26
Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome26
A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis26
Early-life low-calorie sweetener consumption disrupts glucose regulation, sugar-motivated behavior, and memory function in rats26
The RNA receptor RIG-I binding synthetic oligodeoxynucleotide promotes pneumonia survival26
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