JCI Insight

Article	Citations
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation	209
Bariatric surgery improves postprandial VLDL kinetics and restores insulin-mediated regulation of hepatic VLDL production	136
A hypomorphic Mpi mutation unlocks an in vivo tool for studying global N-glycosylation deficiency	135
Pregnancy dedifferentiates memory CD8+ T cells into hypofunctional cells with exhaustion-enriched programs	133
Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV	123
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells	102
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate	99
Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection	97
Ataxia and cerebellar hypoexcitability in a mouse model of SCN1B-linked Dravet syndrome	94
Coimmunomodulation of tumor and tumor-draining lymph nodes during in situ vaccination promotes antitumor immunity	92
Longitudinal analysis of T cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection	84
Myocardial ATP depletion detected noninvasively predicts sudden cardiac death risk in patients with heart failure	83
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models	80
Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish	80
Pharmacological induction of MHC-I expression in tumor cells revitalizes T cell antitumor immunity	79
T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade	78
Fibrotic lung disease inhibits immune responses to staphylococcal pneumonia via impaired neutrophil and macrophage function	76
Recurrent moderate hypoglycemia accelerates the progression of Alzheimer’s disease through impairment of the TRPC6/GLUT3 pathway	73
Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition	73
Irx1 mechanisms for oral epithelial basal stem cell plasticity during reepithelialization after injury	71
Dipeptidase-1–knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer	70
Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction	69
De novo variant in RING finger protein 213 causes systemic vasculopathy	68
The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury	66
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses	66

Effects of SIPA1L1 on trabecular meshwork extracellular matrix protein accumulation and cellular phagocytosis in POAG	65
Dysregulated immunologic landscape of the early host response in melioidosis	65
Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease	63
Longitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians	63
Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity	61
Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice	61
Autosomal-dominant macular dystrophy linked to a chromosome 17 tandem duplication	61
EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice	61
Constitutive deletion of the obscurin-Ig58/59 domains induces atrial remodeling and Ca2+-based arrhythmogenesis	61
11C-Para-aminobenzoic acid PET imaging of S. aureus and MRSA infection in preclinical models and humans	61
LMAN1 serves as a cargo receptor for thrombopoietin	60
CNS-dominant human FMRP isoform rescues seizures, fear, and sleep abnormalities in Fmr1-KO mice	59
Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice	57
Urine proteomic signatures of kidney function decline after hospitalization	56
Development of a humanized mouse model with functional human materno-fetal interface immunity	56
Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas	56
CD4+ and CD8+ T-cells are not the main driver of Lassa fever pathogenesis in macaques	55
Nociceptor neurons promote IgE class switch in B cells	55
Epac1–/– and Epac2–/– mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation	55
Type I interferons and TGF-β cooperate to induce liver fibrosis during HIV-1 infection under antiretroviral therapy	55
BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia	54
CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis	54
Key patient demographics shape innate immune topography in noncritical hypoxic COVID-19 pneumonia	53
UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation	53
Multicomponent parenteral lipid emulsions do not prevent liver injury in neonatal pigs with obstructive cholestasis	53
AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival	53
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion	51
Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV	51
A dominant pathogenic MEFV mutation causes atypical pyrin-associated periodic syndromes	51
Hypoxia-activated prodrug and antiangiogenic therapies cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration	50
Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk	50
Allergen induces pulmonary neuroendocrine cell hyperplasia in a model of asthma	49
Interferon-dependent signaling is critical for viral clearance in airway neutrophils	49
Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule to increase NaCl cotransporter	48
Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy	48
Characterization of anti-cancer therapy-induced microvascular dysfunction in breast cancer patients with proof-of-concept of targeted intervention	48
Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis	48
The timing of auditory sensory deficits in Norrie disease has implications for therapeutic intervention	48
Combination therapy with remdesivir and monoclonal antibodies protects nonhuman primates against advanced Sudan virus disease	47
Caspase-4/11 promotes hyperlipidemia and chronic kidney disease-accelerated vascular inflammation by enhancing trained immunity	47
Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells	47
Prenatal alcohol exposure is associated with altered feto-placental blood flow and sex-specific placental changes	47
mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer	47
First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival	47
Longitudinal trajectories of branched chain amino acids through young adulthood and diabetes in later life	46
Filaggrin loss-of-function variants are associated with atopic dermatitis phenotypes in a diverse, early-life prospective cohort	46
Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation	46
Allele-specific silencing of the gain-of-function mutation in Huntington’s disease using CRISPR/Cas9	45
Differential histone acetylation and super-enhancer regulation underlie melanoma cell dedifferentiation	45
Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial	45

Focusing HIV-1 Gag T cell responses to highly conserved regions by DNA vaccination in HVTN 119	45
Longitudinal associations of insulin resistance with change in bone mineral density in midlife women	45
Regulation of human and mouse bystander T cell activation responses by PD-1	45
A systematic review of geographic indices of disadvantage with implications for older adults	45
Intragraft memory-like CD127hiCD4+Foxp3+ Tregs maintain transplant tolerance	45
hsa-miRNA-548v controls the viscoelastic properties of human cardiomyocytes and improves their relaxation rates	45
Evidence of a Sjögren’s disease–like phenotype following COVID-19 in mice and humans	45
Elevated apolipoprotein C3 augments diabetic kidney disease and associated atherosclerosis in type 2 diabetes	44
FGF receptors mediate cellular senescence in the cystic fibrosis airway epithelium	44
NSD1-916aa encoded by CircNSD1 contributes to AKI-to-CKD transition through inducing ferroptosis in tubular epithelial cells	44
Rapamycin immunomodulation utilizes time-dependent alterations of lymph node architecture, leukocyte trafficking, and gut microbiome	44
Tubulin tyrosine ligase variant perturbs microtubule tyrosination, causing hypertrophy in patient-specific and CRISPR gene-edited iPSC-cardiomyocytes	43
Mitochondria-sequestered Aβ renders synaptic mitochondria vulnerable in the elderly with a risk of Alzheimer disease	43
Enhancing DC cancer vaccine by allogeneic MHC class II expression and Treg depletion	43
Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling	42
IL-15 reprogramming compensates for NK cell mitochondrial dysfunction in HIV-1 infection	42
Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting	42
Single-cell landscape analysis unravels molecular programming of the human B cell compartment in chronic GVHD	42
Cleavage of N-terminus of polycystin-1 increases calcium permeability of polycystin-1/2 receptor channel complexes	42
Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza	41
Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes	41
Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19	41
Bacterial cancer therapy in autochthonous colorectal cancer affects tumor growth and metabolic landscape	40
The hepatokine TSK maintains myofiber integrity and exercise endurance and contributes to muscle regeneration	40
A versatile laser-induced porcine model of outer retinal and choroidal degeneration for preclinical testing	40
Horizontal transmission of gut microbiota attenuates mortality in lung fibrosis	39
Mitochondrial and NAD+ metabolism predict recovery from acute kidney injury in a diverse mouse population	39
New insights into an old question: can the MD-PhD physician-scientist pipeline be improved?	39
Computational estimates of annular diameter reveal genetic determinants of mitral valve function and disease	39
CAVIN3 deficiency promotes vascular normalization in ocular neovascular disease via ERK/JAG1 signaling pathway	39
A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects	39
Mutational landscape of atherosclerotic plaques reveals large clonal cell populations	39
Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID	38
Duration of viral shedding and culture positivity with postvaccination SARS-CoV-2 delta variant infections	38
Intimomedial tears of the aorta heal by smooth muscle cell–mediated fibrosis without atherosclerosis	38
A single-cell atlas of the myometrium in human parturition	38
Islet transplantation into brown adipose tissue can delay immune rejection	38
HIV-1–infected T cell clones are shared across cerebrospinal fluid and blood during ART	38
Multiantigen pan-sarbecovirus DNA vaccines generate protective T cell immune responses	38
HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury	38
Protein kinase G2 activation restores Wnt signaling and bone mass in glucocorticoid-induced osteoporosis in mice	38
Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep	38
Profound reduction of HIV-1 reservoir cells over 3 decades of antiretroviral therapy started in early infancy	38
Immunological landscape of human lymphoid explants during measles virus infection	38
Adrenal-permissive HSD3B1 genetic inheritance and risk of estrogen-driven postmenopausal breast cancer	38
ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression	37
In vivo AAV9-Myo7a gene rescue restores hearing and cholinergic efferent innervation in inner hair cells	37
Anoctamin-5 deficiency enhances ATG9A-dependent autophagy, inducing osteogenesis and gnathodiaphyseal dysplasia–like bone formation	37
Temporal development of T cell receptor repertoires during childhood in health and disease	37
Isolevuglandins disrupt PU.1-mediated C1q expression and promote autoimmunity and hypertension in systemic lupus erythematosus	37
β-Catenin disruption decreases macrophage exosomal α-SNAP and impedes Treg differentiation in acute liver injury	37
Bioactive extracellular vesicles from a subset of endothelial progenitor cells rescue retinal ischemia and neurodegeneration	37
An immunosuppressed microenvironment distinguishes lateral ventricle–contacting glioblastomas	37
Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models	37
β Cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood	37
SPOP mutations increase PARP inhibitor sensitivity via CK2/PIAS1/SPOP axis in prostate cancer	37
Rapid systemic spread and minimal immune responses following SIVsab intrarectal transmission in African green monkeys	37
Improved mitochondrial function in the hearts of sarcolipin-deficient dystrophin and utrophin double-knockout mice	36
Modeling skeletal dysplasia in Hurler syndrome using patient-derived bone marrow osteoprogenitor cells	36
Uric acid formation is driven by crosstalk between skeletal muscle and other cell types	36
Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma	36
Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota	36
Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis	36
Cross-species single-cell analysis uncovers the immunopathological mechanisms associated with IgA nephropathy progression	36
Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation	36
The gut microbiome enhances breast cancer immunotherapy following bariatric surgery	36
A phase I study of autologous mesenchymal stromal cells for severe steroid-dependent nephrotic syndrome	35
SARS-CoV-2 infection of sustentacular cells disrupts olfactory signaling pathways	35
The EMT factor ZEB1 paradoxically inhibits EMT in BRAF-mutant carcinomas	35
Inhibition of ceramide accumulation in AdipoR1–/– mice increases photoreceptor survival and improves vision	35
The aberrant tonsillar microbiota modulates autoimmune responses in rheumatoid arthritis	35
HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART	34
Single-nucleus RNA-Seq reveals singular gene signatures of human ductal cells during adaptation to insulin resistance	34
Evaluating precision medicine approaches for gene therapy in patient-specific cellular models of Bietti crystalline dystrophy	34
Expansion of the HSV-2–specific T cell repertoire in skin after immunotherapeutic HSV-2 vaccine	34
Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer	34
Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in Trappc9-linked brain developmental syndrome	34
Ebola virus protein VP40 stimulates IL-12– and IL-18–dependent activation of human natural killer cells	34
Dichloroacetate improves mitochondrial function, physiology, and morphology in FBXL4 disease models	34
Thyroidal expression of ER molecular chaperone GRP170 is required for efficient TSH-mediated thyroid hormone synthesis	34

Association of oxidized ApoB and oxidized ApoA-I with high-risk coronary plaque features in cardiovascular disease	34
Catalytic isoforms of AMP-activated protein kinase differentially regulate IMPDH activity and photoreceptor neuron function	34
A dynamic mucin mRNA signature associates with COVID-19 disease presentation and severity	34
Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response	33
Cord blood proteomics identifies biomarkers of early-onset neonatal sepsis	33
Transcriptome and microbiome-immune changes across preinvasive and invasive anal cancer lesions	33
Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment	33
Preservation of naive-phenotype CD4+ T cells after vaccination contributes to durable immunity	33
SARA suppresses myofibroblast precursor transdifferentiation in fibrogenesis in a mouse model of scleroderma	33
Endothelial response to blood-brain barrier disruption in the human brain	33
Hypercapnia alters stroma-derived Wnt production to limit β-catenin signaling and proliferation in AT2 cells	33
NETs decorated with bioactive IL-33 infiltrate inflamed tissues and induce IFN-α production in patients with SLE	33
CD34hi subset of synovial fibroblasts contributes to fibrotic phenotype of human knee osteoarthritis	32
SLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine	32
Circulating extracellular vesicles in human cardiorenal syndrome promote renal injury in a kidney-on-chip system	32
Piperlongumine overcomes osimertinib resistance via governing ubiquitination-modulated Sp1 turnover	32
Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells	32
Mechanisms underlying age-associated exacerbation of pulmonary veno-occlusive disease	32
Effects of FGF21, soluble TGFBR2, and environmental temperature on metabolic dysfunction in lipodystrophic mice	32
Intergenic sequences harboring potential enhancer elements contribute to Axenfeld-Rieger syndrome by regulating PITX2	32
Identification and validation of a T cell receptor targeting KRAS G12V in HLA-A*11:01 pancreatic cancer patients	32
Orai1 calcium channel inhibition prevents progression of chronic pancreatitis	32
Perivascular inflammation in the progression of aortic aneurysms in Marfan syndrome	32
IFN-λ uniquely promotes CD8 T cell immunity against SARS-CoV-2 relative to type I IFN	31
KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis	31
Restoring calcium homeostasis in Purkinje cells arrests neurodegeneration and neuroinflammation in the ARSACS mouse model	31
Human immune phenotyping reveals accelerated aging in type 1 diabetes	31
Predictive value of TCR Vβ-Jβ profile for adjuvant gefitinib in EGFR mutant NSCLC from ADJUVANT-CTONG 1104 trial	31
Ancestry-based differences in the immune phenotype are associated with lupus activity	31
suPAR links a dysregulated immune response to tissue inflammation and sepsis-induced acute kidney injury	31
Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation	31
Inhibition of the renin-angiotensin system causes concentric hypertrophy of renal arterioles in mice and humans	31
LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3	31
DAB2IP loss in luminal a breast cancer leads to NF-κB–associated aggressive oncogenic phenotypes	31
Endothelial PRMT5 plays a crucial role in angiogenesis after acute ischemic injury	31
ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion	31
HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury	30
Oxygen-carrying nanoemulsions and respiratory hyperoxia eliminate tumor hypoxia–induced immunosuppression	30
IL-33 activates group 2 innate lymphoid cell expansion and modulates endometriosis	30
S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury	30
Involvement of impaired carnitine-induced fatty acid oxidation in experimental and human diabetic kidney disease	30
PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils	30
Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss	30
CCL3 in the bone marrow microenvironment causes bone loss and bone marrow adiposity in aged mice	30
Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency	30
ABT1 modifies SMARD1 pathology via interactions with IGHMBP2 and stimulation of ATPase and helicase activity	30
Functional Pdgfra fibroblast heterogeneity in normal and fibrotic mouse lung	30
Deciphering the tumor microenvironment cell–infiltrating landscape reveals microenvironment subtypes and therapeutic potentials for nonsquamous NSCLC	30
DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3	29
Label-free single-cell phenotyping to determine tumor cell heterogeneity in pancreatic cancer in real time	29
4PBA reduces growth deficiency in osteogenesis imperfecta by enhancing transition of hypertrophic chondrocytes to osteoblasts	29
Osteopontin promotes age-related adipose tissue remodeling through senescence-associated macrophage dysfunction	29
Mitochondrial β-oxidation of adipose-derived fatty acids by osteoblasts fuels parathyroid hormone–induced bone formation	29
Circular RNA Cdr1as inhibits proliferation and delays injury-induced regeneration of the intestinal epithelium	29
p53 maintains lineage fidelity during lung capillary injury-repair in neonatal hyperoxia	29
Histamine-induced RPS6 phosphorylation in dendritic cells is associated with the severity of peanut allergic reactions	29
A miRNA/CXCR4 signaling axis impairs monopoiesis and angiogenesis in diabetic critical limb ischemia	29
The administration of exogenous HSP47 as a collagen-specific therapeutic approach	29
ERK hyperactivation in epidermal keratinocytes impairs intercellular adhesion and drives Grover disease pathology	29
Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators	29
NEXN regulates vascular smooth muscle cell phenotypic switching and neointimal hyperplasia	29
AI-assisted discovery of an ethnicity-influenced driver of cell transformation in esophageal and gastroesophageal junction adenocarcinomas	29
Intraperitoneal injection of class A TLR9 agonist enhances anti–PD-1 immunotherapy in colorectal peritoneal metastases	29
Lipid metabolism analysis reveals that DGAT1 regulates Th17 survival by controlling lipid peroxidation in uveitis	29
Radiotherapy exposure directly damages the uterus and causes pregnancy loss	28
New Pseudomonas infections drive Pf phage transmission in CF airways	28
SNRNP70 regulates the splicing of CD55 to promote osteosarcoma progression	28
Heterogeneity of thymic output in the elderly and its association with sex and smoking	28
Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes	28
The ACTH test fails to diagnose adrenal insufficiency and augments cytokine production in sepsis	28
A Notch/IL-21 signaling axis primes bone marrow T cell progenitor expansion	28
Transcriptional control of a collagen deposition and adhesion process that promotes lung adenocarcinoma growth and metastasis	28
A peptide blocking the ADORA1-neurabin interaction is anticonvulsant and inhibits epilepsy in an Alzheimer’s model	28
Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells	27
The receptor BLT1 is essential on neutrophils in a mouse model of mucous membrane pemphigoid	27
Leukocytes mediate disease pathogenesis in the Ndufs4(KO) mouse model of Leigh syndrome	27
ISG15/GRAIL1/CD3 axis influences survival of patients with esophageal adenocarcinoma	27
Granzyme B cleaves tenascin-C to release its C-terminal domain in rheumatoid arthritis	27
Individual transcriptomic response to strength training for patients with myotonic dystrophy type 1	27
Immunosurveillance shapes the emergence of neo-epitope landscapes of sarcomas, revealing prime targets for immunotherapy	27
Characterization of HMGA2 variants expands the spectrum of Silver-Russell syndrome	27
Parathyroid hormone 1 receptor signaling mediates breast cancer metastasis to bone in mice	27
Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding	27
Rapamycin rescues loss of function in blood-brain barrier–interacting Tregs	27
Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies against self-antigens	27
Spheroids as a model for endometriotic lesions	27
Targeting activin receptor–like kinase 7 ameliorates adiposity and associated metabolic disorders	26
Role of cGAS/STING pathway in aging and sexual dimorphism in diabetic kidney disease	26
Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection	26
A therapeutic HBV vaccine containing a checkpoint modifier enhances CD8+ T cell and antiviral responses	26
Chemotherapy delivery time affects treatment outcomes of female patients with diffuse large B cell lymphoma	26
Antisense oligonucleotide therapy for KCNT1 encephalopathy	26
Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy	26
CTNND1 variants cause familial exudative vitreoretinopathy through the Wnt/cadherin axis	26
Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma	26