OOIR: Observatory of International Research

Papers

(The TQCC of Bioengineering & Translational Medicine is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Nanoparticles in the clinic: An update post COVID‐19 vaccines	175
Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles	136
Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect	108
Viral vector‐based gene therapies in the clinic	106
A review of biomimetic scaffolds for bone regeneration: Toward a cell‐free strategy	73
Cell therapies in the clinic	70
Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo	69
An engineered probiotic secreting Sj16 ameliorates colitis via Ruminococcaceae/butyrate/retinoic acid axis	50
Alzheimer's and Parkinson's disease therapies in the clinic	48
(Nano)platforms in bladder cancer therapy: Challenges and opportunities	45
Temporal profiling of cytokines in passively expressed sweat for detection of infection using wearable device	45
Doxorubicin‐loaded nanoparticle coated with endothelial cells‐derived exosomes for immunogenic chemotherapy of glioblastoma	45
Therapeutic potential of extracellular vesicle‐associated long noncoding RNA	42
The effect of size, charge, and peptide ligand length on kidney targeting by small, organic nanoparticles	40
Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy	39
Advanced strategies to thwart foreign body response to implantable devices	39
Nanocomposite hydrogels for biomedical applications	37
Fourth‐generation glucose sensors composed of copper nanostructures for diabetes management: A critical review	37
Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress	35
Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands	35
In situ forming microporous gelatin methacryloyl hydrogel scaffolds from thermostable microgels for tissue engineering	34
Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering	34
Magnetic microgels and nanogels: Physical mechanisms and biomedical applications	33
Biomimetic cell membrane‐coated poly(lactic‐co‐glycolic acid) nanoparticles for biomedical applications	33
RNA therapeutics in the clinic	33

Clinical translation of choline and geranic acid deep eutectic solvent	32
Polylysine for skin regeneration: A review of recent advances and future perspectives	32
Cell loaded hydrogel containing Ag‐doped bioactive glass–ceramic nanoparticles as skin substitute: Antibacterial properties, immune response, and scarless cutaneous wound regeneration	32
A review of biomarkers in the context of type 1 diabetes: Biological sensing for enhanced glucose control	31
Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice	31
Ferrostatin‐1‐loaded liposome for treatment of corneal alkali burn via targeting ferroptosis	31
Design and clinical application of injectable hydrogels for musculoskeletal therapy	30
Mussel‐inspired biomaterials: From chemistry to clinic	29
Mitochondrial transplantation therapy inhibit carbon tetrachloride‐induced liver injury through scavenging free radicals and protecting hepatocytes	29
Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects	28
Bio‐functional hydrogel with antibacterial and anti‐inflammatory dual properties to combat with burn wound infection	27
Radiation nanosensitizers in cancer therapy—From preclinical discoveries to the outcomes of early clinical trials	27
IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐Cov‐2) with digital drug development	26
Current diagnostic tools for coronaviruses–From laboratory diagnosis to POC diagnosis for COVID‐19	26
PRADA: Portable Reusable Accurate Diagnostics with nanostar Antennas for multiplexed biomarker screening	23
Adaptive multi‐degree‐of‐freedom in situ bioprinting robot for hair‐follicle‐inclusive skin repair: A preliminary study conducted in mice	23
Nanomaterials‐based sensors for the detection of COVID‐19: A review	21
Cartilage‐targeting ultrasmall lipid‐polymer hybrid nanoparticles for the prevention of cartilage degradation	21
Exosomes derived from olfactory ensheathing cells provided neuroprotection for spinal cord injury by switching the phenotype of macrophages/microglia	21
Ultra‐thin, high strength, antibiotic‐eluting sutures for prevention of ophthalmic infection	20
Hyaluronic acid–doxorubicin nanoparticles for targeted treatment of colorectal cancer	20
Injection of hybrid 3D spheroids composed of podocytes, mesenchymal stem cells, and vascular endothelial cells into the renal cortex improves kidney function and replenishes glomerular podo	20
An updated review of SARS‐CoV‐2 detection methods in the context of a novel coronavirus pandemic	19
ε‐poly‐L‐lysine‐modified polydopamine nanoparticles for targeted photothermal therapy of drug‐resistant bacterial keratitis	19
Engineered macrophage membrane‐enveloped nanomedicine for ameliorating myocardial infarction in a mouse model	19
A high‐throughput biomimetic bone‐on‐a‐chip platform with artificial intelligence‐assisted image analysis for osteoporosis drug testing	19
Targeted systemic dendrimer delivery of CSF‐1R inhibitor to tumor‐associated macrophages improves outcomes in orthotopic glioblastoma	18
Potent neutralization of SARS‐CoV‐2 including variants of concern by vaccines presenting the receptor‐binding domain multivalently from nanoscaffolds	18
Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls	18
Synergistic strategy with hyperthermia therapy based immunotherapy and engineered exosomes−liposomes targeted chemotherapy prevents tumor recurrence and metastasis in advanced breast cancer	18
Matrix stiffness mechanosensing modulates the expression and distribution of transcription factors in Schwann cells	18
Internet‐of‐medical‐things integrated point‐of‐care biosensing devices for infectious diseases: Toward better preparedness for futuristic pandemics	18
Mesenchymal stem cell‐inspired microgel scaffolds to control macrophage polarization	18
The wasp venom antimicrobial peptide polybia‐CP and its synthetic derivatives display antiplasmodial and anticancer properties	17
Point‐of‐care semen analysis of patients with infertility via smartphone and colorimetric paper‐based diagnostic device	17
Enhanced tumor cell killing by ultrasound after microtubule depolymerization	16
A bioinspired synthetic soft hydrogel for the treatment of dry eye	16
Integrated bioactive scaffold with aptamer‐targeted stem cell recruitment and growth factor‐induced pro‐differentiation effects for anisotropic meniscal regeneration	16
Nanoparticle‐microglial interaction in the ischemic brain is modulated by injury duration and treatment	16
Graphene quantum dots‐based targeted nanoprobes detecting drug delivery, imaging, and enhanced chemotherapy of nasopharyngeal carcinoma	16
Biomedical applications of three‐dimensional bioprinted craniofacial tissue engineering	16
Portable hand‐held bioprinters promote in situ tissue regeneration	16
Gemcitabine and doxorubicin in immunostimulatory monophosphoryl lipid A liposomes for treating breast cancer	15
The effect of local non‐thermal plasma therapy on the cancer‐immunity cycle in a melanoma mouse model	15
A skin patch integrating swellable microneedles and electrochemical test strips for glucose and alcohol measurement in skin interstitial fluid	15
Transplantation of bioengineered Reelin‐loadedPLGA/PEGmicelles can accelerate neural tissue regeneration in photothrombotic stroke model of mouse	15
Preclinical study of peripheral nerve regeneration using nerve guidance conduits based on polyhydroxyalkanaotes	15
In‐cytoplasm mitochondrial transplantation for mesenchymal stem cells engineering and tissue regeneration	15
Phage engineering and phage‐assisted CRISPR‐Cas delivery to combat multidrug‐resistant pathogens	14
Resection and survival data from a clinical trial of glioblastoma multiforme‐specific IRDye800‐BBN fluorescence‐guided surgery	14

E3 ligase activity of Carboxyl terminus of Hsc70 interacting protein (CHIP) in Wharton's jelly derived mesenchymal stem cells improves their persistence under hyperglycemic stres	14
Injectable hyaluronic acid hydrogels encapsulating drug nanocrystals for long‐term treatment of inflammatory arthritis	14
Analysis of aqueous humor total antioxidant capacity and its correlation with corneal endothelial health	14
Brain‐targeted exosome‐mimetic cell membrane nanovesicles with therapeutic oligonucleotides elicit anti‐tumor effects in glioblastoma animal models	14
Macrophage‐targeted delivery of siRNA to silence Mecp2 gene expression attenuates pulmonary fibrosis	14
Validation of the 1,4‐butanediolthermoplastic polyurethane as a novel material for3Dbioprinting applications	14
Nanomaterials for mRNA‐based therapeutics: Challenges and opportunities	14
Resolvin D1‐loaded nanoliposomes promote M2 macrophage polarization and are effective in the treatment of osteoarthritis	14
miRNA‐encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers	14
Current status of targeted microbubbles in diagnostic molecular imaging of pancreatic cancer	13
Reactive oxygen species‐responsive mitochondria‐targeted liposomal quercetin attenuates retinal ischemia–reperfusion injury via regulating SIRT1/FOXO3A and p38 MAPK si	13
A bioprinted complex tissue model for myotendinous junction with biochemical and biophysical cues	13
Recent progress in the manipulation of biochemical and biophysical cues for engineering functional tissues	12
LINC00473‐modified bone marrow mesenchymal stem cells incorporated thermosensitive PLGA hydrogel transplantation for steroid‐induced osteonecrosis of femoral head: A detailed mec	12
Blood vessel remodeling in late stage of vascular network reconstruction is essential for peripheral nerve regeneration	12
A biomimetic hyaluronic acid‐silk fibroin nanofiber scaffold promoting regeneration of transected urothelium	12
Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson's disease in mice by delivering GLP‐1 and modulating gut microbiota	12
Fabrication of bone‐derived decellularized extracellular matrix/ceramic‐based biocomposites and their osteo/odontogenic differentiation ability for dentin regeneration	12
Kartogenin (KGN)/synthetic melanin nanoparticles (SMNP) loaded theranostic hydrogel scaffold system for multiparametric magnetic resonance imaging guided cartilage regeneration	12
Multifunctional electrospun asymmetric wettable membrane containing black phosphorus/Rg1 for enhancing infected wound healing	12
Intra‐articular injection of rapamycin microparticles prevent senescence and effectively treat osteoarthritis	12
Silk fibroin and ceramic scaffolds: Comparative in vitro studies for bone regeneration	12
Novel nanofibrous membrane‐supporting stem cell sheets for plasmid delivery and cell activation to accelerate wound healing	11
Targeting thymidine phosphorylase as a potential therapy for bone loss associated with periprosthetic osteolysis	11
Application of polymersomes in membrane protein study and drug discovery: Progress, strategies, and perspectives	11
Hyaluronic acid‐g‐lipoic acid granular gel for promoting diabetic wound healing	11
Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing	11
Photoresponsive prodrug‐dye nanoassembly for in‐situ monitorable cancer therapy	11
Transcriptomic response of brain tissue to focused ultrasound‐mediated blood–brain barrier disruption depends strongly on anesthesia	10
3D bioprinting of an implantable xeno‐free vascularized human skin graft	10
Ultrasound‐microbubble cavitation facilitates adeno‐associated virus mediated cochlear gene transfection across the round‐window membrane	10
Sprayable tissue adhesive with biodegradation tuned for prevention of postoperative abdominal adhesions	10
Microsampling tools for collecting, processing, and storing blood at the point‐of‐care	10
Prediction of drug permeation through microneedled skin by machine learning	10
Predicting T‐cell quality during manufacturing through an artificial intelligence‐based integrative multiomics analytical platform	10
Recent advances in cellular biosensor technology to investigate tau oligomerization	10
Personalized‐induced neural stem cell therapy: Generation, transplant, and safety in a large animal model	10
Tracking metabolic responses based on macronutrient consumption: A comprehensive study to continuously monitor and quantify dual markers (cortisol and glucose) in human sweat using WATCH se	10
Formulation‐based approaches for dermal delivery of vaccines and therapeutic nucleic acids: Recent advances and future perspectives	10
Hydrogel viscoelasticity modulates migration and fusion of mesenchymal stem cell spheroids	10
Tripartite collaboration of blood‐derived endothelial cells, next generation RNA sequencing and bioengineered vessel‐chip may distinguish vasculopathy and thrombosis among sickle cell disea	9
Engineering elastic sealants based on gelatin and elastin‐like polypeptides for endovascular anastomosis	9
Customized flexible hollow microneedles for psoriasis treatment with reduced‐dose drug	9
An ion‐paired moxifloxacin nanosuspension eye drop provides improved prevention and treatment of ocular infection	9
Platelet membrane camouflaged AIEgen‐mediated photodynamic therapy improves the effectiveness of anti‐PD‐L1 immunotherapy in large‐burden tumors	9
Injectable bioactive glass/sodium alginate hydrogel with immunomodulatory and angiogenic properties for enhanced tendon healing	9
Screening method to identify hydrogel formulations that facilitate myotube formation from encapsulated primary myoblasts	9
Flourishing tumor organoids: History, emerging technology, and application	9
Fe‐containing metal–organic framework with D‐penicillamine for cancer‐specific hydrogen peroxide generation and enhanced chemodynamic therapy	9
Micro and nanotechnologies: The little formulations that could	9
Cell stiffness predicts cancer cell sensitivity to ultrasound as a selective superficial cancer therapy	9
The microbiota‐gut‐brain axis and epilepsy from a multidisciplinary perspective: Clinical evidence and technological solutions for improvement of in vitro preclinical models	9
Application of photoacoustic computed tomography in biomedical imaging: A literature review	9
Hyperelastic, shape‐memorable, and ultra‐cell‐adhesive degradable polycaprolactone‐polyurethane copolymer for tissue regeneration	9
Transplantation of neuron‐inducing grafts embedding positively charged gold nanoparticles for the treatment of spinal cord injury	9
Layer‐by‐layer interleukin‐12 nanoparticles drive a safe and effective response in ovarian tumors	8
Therapeutic potential of nanoceria pretreatment in preventing the development of urological chronic pelvic pain syndrome: Immunomodulation via reactive oxygen species scavenging and SerpinB2	8
Engineering placenta‐like organoids containing endogenous vascular cells from human‐induced pluripotent stem cells	8
Development of nintedanib nanosuspension for inhaled treatment of experimental silicosis	8
Polysaccharide‐based biomaterials in a journey from 3D to 4D printing	8
SERS spectroscopy with machine learning to analyze human plasma derived sEVs for coronary artery disease diagnosis and prognosis	8
Long term therapeutic effects of icariin‐loaded PLGA microspheres in an experimental model of optic nerve ischemia via modulation of CEBP‐β/G‐CSF/noncanonical NF‐	8
An EPO‐loaded multifunctional hydrogel synergizing with adipose‐derived stem cells restores neurogenic erectile function via enhancing nerve regeneration and penile rehabilitation	8
Evaluation of native and non‐native biomaterials for engineering human skin tissue	8
Synergy of antioxidant and M2 polarization in polyphenol‐modified konjac glucomannan dressing for remodeling wound healing microenvironment	8
Targeted brain delivery of RVG29‐modified rifampicin‐loaded nanoparticles for Alzheimer's disease treatment and diagnosis	8
Sonodynamic therapy reduces iron retention of hemorrhagic plaque	8
Wearable biosensors for human fatigue diagnosis: A review	8
Digital therapeutics in the clinic	8
Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling	8
Human fetal mesenchymal stem cells secretome promotes scarless diabetic wound healing through heat‐shock protein family	8