OOIR: Observatory of International Research

Papers

(The TQCC of Bioengineering & Translational Medicine is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
USENSE: A proof‐of‐concept self‐screening tool for home‐based recurrent urinary tract infection management	198
Correction to “Self‐assembly of PEG–PPS polymers and LL‐37 peptide nanomicelles improves the oxidative microenvironment and promotes angiogenesis to facilitate chronic	142
miRNA‐encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers	108
Liver‐tumor mimics as a potential translational framework for planning and testing irreversible electroporation with multiple electrodes	103
Polymorphic nanobody crystals as long‐acting intravitreal therapy for wet age‐related macular degeneration	100
Evaluation of the efficacy and safety of ionic liquids containing ketoconazole in patients with tinea pedis: A randomized controlled clinical trial	99
Insights into the mechanisms, regulation, and therapeutic implications of extracellular matrix stiffness in cancer	93
4D‐CT deformable image registration using unsupervised recursive cascaded full‐resolution residual networks	87
Vitrification and rapid rewarming of precision‐cut liver slices for pharmacological and biomedical research	82
Fortifying angiogenic efficacy of conditioned media using phototoxic‐free blue light for wound healing	81
A high‐throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell‐based assays	72
Dynamic pillar–perfusion platform for screening enzyme‐induced self‐assembling peptide therapeutics in 3D breast cancer spheroids	67
A soft, bioinspired artificial lymphatic system for interactive ascites transfer	66
Customized flexible hollow microneedles for psoriasis treatment with reduced‐dose drug	65
Application of hydrogels in 3D tumor microenvironment modeling and drug screening for cervical cancer: A review	60
PEGylated thymosin β4 is a thiol‐site‐specific prodrug treating myocardial infarction in vivo	60
An in‐cell helicase reporter system for quantifying DDX3X and DDX3Y activities	59
Disease modifying biomaterials for modulating mechanical allodynia in a preclinical model of rheumatoid arthritis	57
Biomimetic nanotherapeutics for targeted drug delivery to glioblastoma multiforme	55
Revolutionizing cancer treatment: The multifaceted role of graphene oxide in modern oncology	54
Mitomycin C‐immobilized silver nanoparticle‐loaded polycaprolactone membrane for temporary scalp expansion after decompressive craniectomy to prevent wound infection	53
Kidney organoids as a novel platform to evaluate heat‐stress‐induced acute kidney injury pathogenesis	52
Novel metal peroxide nanoboxes restrain Clostridioides difficile infection beyond the bactericidal	51
Bridging the gap in OA therapeutics: Bioengineered strategies to target osteoclast–chondrocyte crosstalk	50
A polymer‐based systemic hemostat for managing uncontrolled bleeding	46

Light controlled self‐escape capability of non‐cationic carbon nitride‐based nanosheets in lysosomes for hepatocellular carcinoma targeting stimulus‐responsive gene delivery	45
Stirred culture of cartilaginous microtissues promotes chondrogenic hypertrophy through exposure to intermittent shear stress	44
Clathrin light chain‐conjugated drug delivery for cancer	43
ROS ‐responsive robust hydrogels based on thiol‐ene click chemistry for enhancing the healing of infected wounds	43
Mussel‐inspired biomaterials: From chemistry to clinic	42
Matrix metalloproteinase 2‐responsive dual‐drug‐loaded self‐assembling peptides suppress tumor growth and enhance breast cancer therapy	42
Fluidic integrated 3D bioprinting system to sustain cell viability towards larynx fabrication	40
Soluble CD80 oral delivery by recombinant Lactococcus suppresses tumor growth by enhancing antitumor	40
Ultrasound‐guided interstitial photothermal therapy generates improved treatment responses in a 9464D model of neuroblastoma	40
Preparation and assessment of an optimized multichannel acellular nerve allograft for peripheral nerve regeneration	40
An ultralow power wearable vital sign sensor using an electromagnetically reactive near field	40
Deep learning‐based multimodal fusion network for segmentation and classification of breast cancers using B‐mode and elastography ultrasound images	39
Digital therapeutics in the clinic	38
Innovative myeloid ecotropic viral integration site 1‐engineered exosome platform combating oxidative stress and inflammation in acute pulmonary damage	37
Green/red fluorescent protein disrupting drugs for real‐time permeability tracking in three‐dimensional tumor spheroids	37
Issue Information	36
Correction to “A stretchable, electroconductive tissue adhesive for the treatment of neural injury”	35
Integrated ATAC‐seq and RNA‐seq analysis identifies key regulatory elements in NK cells activated with feeder cells and IL‐2	34
Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing	34
The emerging role of heart‐on‐a‐chip systems in delineating mechanisms of SARS‐CoV‐2‐induced cardiac dysfunction	34
Single immunization with an influenza hemagglutinin nanoparticle‐based vaccine elicits durable protective immunity	34
Injectable bioactive glass/sodium alginate hydrogel with immunomodulatory and angiogenic properties for enhanced tendon healing	33
Engineered probiotic ameliorates hyperlipidemia and atherosclerosis by secreting PCSK9 nanobodies and regulating gut microbiota	33
Feasibility of engineered Bacillus subtilis for use as a microbiome‐based topical drug delivery platform	33
Engineering human peritoneum in vitro: A novel microfluidic platform for modeling peritoneal physiology and pathophysiology	33
Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation	33
Statistical process monitoring creates a hemodynamic trajectory map after pediatric cardiac surgery: A case study of the arterial switch operation	33
Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy	32
Biomembrane‐coated nanosystems as next‐generation delivery systems for the treatment of gastrointestinal cancers	31
Macrophage‐based delivery of anti‐fibrotic proteins alleviates bleomycin‐induced pulmonary fibrosis in mice	30
Issue Information	30
Machine learning‐assisted point‐of‐care diagnostics for cardiovascular healthcare	30
Pluronic F127 “nanoarmor” for stabilization of Cowpea mosaic virus immunotherapy	30
Leadership transition	29
Macromolecular nanoparticles to attenuate both reactive oxygen species and inflammatory damage for treating Alzheimer's disease	29
Cold air plasma improving rheumatoid arthritis via mitochondrial apoptosis pathway	29
Site‐specific noninvasive delivery of retrograde viral vectors to the brain	29
Dissolved gases from pressure changes in the lungs elicit an immune response in human peripheral blood	28
Modulating neuroinflammation through molecular, cellular and biomaterial‐based approaches to treat spinal cord injury	28
A stretchable, electroconductive tissue adhesive for the treatment of neural injury	27
ε‐poly‐L‐lysine‐modified polydopamine nanoparticles for targeted photothermal therapy of drug‐resistant bacterial keratitis	27
Microfluidic approaches for liquid biopsy in glioblastoma: Insights into diagnostic and follow‐up strategies	27
Synergistic combination therapy delivered via layer‐by‐layer nanoparticles induces solid tumor regression of ovarian cancer	27
Revolutionizing nephrocalcinosis treatment: IL ‐10 engineered macrophages as a novel therapeutic approach	26
Feasibility and pharmacokinetic evaluation of a needle‐free injector for delivering high concentration antibody formulations	26
Hypoxia‐preconditioned adipose‐derived stem cells with injectable small intestinal submucosa for enhanced cartilage repair in osteoarthritis	26
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Issue Information	25
Staphylococcal proliferation on skin models to investigate novel anti‐infective treatments against dysbiosis	24
Investigating the impact of hypoxia and syncytialization on lipid nanoparticle‐mediated mRNA delivery to placental cells	24

Pediatric pulmonary valve replacements: Clinical challenges and emerging technologies	24
Antibody drug conjugates in the clinic	23
Synchronously in vivo real‐time monitoring bacterial load and temperature with evaluating immune response to decipher bacterial infection	23
Sensor‐integrated brain‐on‐a‐chip platforms: Improving the predictive validity in neurodegenerative research	23
Photobiomodulation improves functional recovery after mild traumatic brain injury	23
Combined use of microbubbles of various sizes and single‐transducer dual‐frequency ultrasound for safe and efficient inner ear drug delivery	23
Magnetic nanoparticles enhance the cellular immune response of dendritic cell tumor vaccines by realizing the cytoplasmic delivery of tumor antigens	23
“Guide” of muscone modification enhanced brain‐targeting efficacy and anti‐glioma effect of lactoferrin modified DTX liposomes	22
Three‐dimensional morphological revealing of human placental villi with common obstetric complications via optical coherence tomography	22
3D printed nerve guidance conduit for biologics‐free nerve regeneration and vascular integration	22
Generation and ex vivo characterization of a full‐thickness substitute of the human urethra by tissue engineering	21
Targeting the epigenome with advanced delivery strategies for epigenetic modulators	21
Macrophages overexpressing interleukin‐10 target and prevent atherosclerosis: Regression of plaque formation and reduction in necrotic core	21
Cardiovascular patches applied in congenital cardiac surgery: Current materials and prospects	21
Machine learning‐directed electrical impedance tomography to predict metabolically vulnerable plaques	21
Galactosylated hydroxyl‐ polyamidoamine dendrimer targets hepatocytes and improves therapeutic outcomes in a severe model of acetaminophen poisoning‐	21
Human fetal mesenchymal stem cells secretome promotes scarless diabetic wound healing through heat‐shock protein family	20
Issue Information	20
Orthogonally crosslinked gelatin methacryloyl microgels for in situ assembly of granular hydrogel scaffolds	20
Elucidating the role of carrier proteins in cytokine stabilization within double emulsion‐based polymeric nanoparticles	20
Synergistic drug combination screening using a nanodroplet processing platform to enhance neuroblastoma treatment in TH‐MYCN transgenic mice	20
Gellan gum spongy‐like hydrogel‐based dual antibiotic therapy for infected diabetic wounds	19
Design and pharmacodynamic study of live biotherapeutic products with efficient degradation of branched‐chain amino acids	19
Advances in high throughput cell culture technologies for therapeutic screening and biological discovery applications	19
Optogenetic modulation of peripheral nociceptive neurons with biocompatible optoelectronic implants	19
Precise mimicry of physiological Ca ²⁺ oscillations for mammalian oocyte activation by nanosecond pulsed electric field	19
Deep learning in precision medicine and focus on glioma	19
The combination of resveratrol and Bletilla striata polysaccharide decreases inflammatory markers of early osteoarthritis knee and the preliminary result	19
Rapid, label‐free enrichment of lymphocytes in a closed system using a flow‐through microfluidic device	19
Advanced technologies for biomedical applications by emerging researchers in Asia‐Pacific	18
In vivo immunogenicity assessment of a multiepitope‐displayed phage vaccine against Brucella species infection in BALB/c mice	18
Glioma chemotherapeutic resistance is tied to membrane electrophysiological properties and glycosylation	18
Facile minocycline deployment in gingiva using a dissolvable microneedle patch for the adjunctive treatment of periodontal disease	18
Fecal microbiota transplantation for the treatment of intestinal and extra‐intestinal diseases: Mechanism basis, clinical application, and potential prospect	18
Needle to needle robot‐assisted manufacture of cell therapy products	18
Utilizing induced neural stem cell‐based delivery of a cytokine cocktail to enhance chimeric antigen receptor‐modified T‐cell therapy for brain cancer	18
Bilayer 3D co‐culture platform inducing the differentiation of normal fibroblasts into cancer‐associated fibroblast like cells: New in vitro source t	18
Nanoporous electroporation needle for localized intracellular delivery in deep tissues	17
Microneedles loaded with glutathione‐scavenging composites for nitric oxide enhanced photodynamic therapy of melanoma	17
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Thermosensitive hydrogel‐based GPR124 delivery strategy for rebuilding blood‐spinal cord barrier	17
Adipose‐derived stem cells enriched with therapeutic mRNA TGF‐β3 and IL‐10 synergistically promote scar‐less wound healing in preclinical models	17
Nanoparticle contrast‐enhanced computed tomography and magnetic resonance imaging of vascularization of a subcutaneous niche for islet transplantation	17
SHEAR saliva collection device augments sample properties for improved analytical performance	16
Automated microarray platform for single‐cell sorting and collection of lymphocytes following HIV reactivation	16
Nanorod/nanodisk‐integrated liquid crystalline systems for starvation, chemodynamic, and photothermal therapy of cancer	16
Fluid mechanical performance of ureteral stents: The role of side hole and lumen size	16
Eye of the future: Unlocking the potential utilization of hydrogels in intraocular lenses	16
Diagnosis of pregnancy disorder in the first‐trimester patient plasma with Raman spectroscopy and protein analysis	16
Atomic force spectroscopy‐based essay to evaluate oocyte postovulatory aging	16
Enabling next‐generation therapies: A foreword to a special issue on nanotechnology in medicine	16
Mesenchymal stem cells paracrine proteins from three‐dimensional dynamic culture system promoted wound healing in third‐degree burn models	16
In vivo evaluation of decellularized skeletal muscle matrices for skeletal muscle repair: A systematic review	16
A double‐edged sword: The complex interplay between engineered nanoparticles and platelets	16
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Corroded iron stent increases fibrin deposition and promotes endothelialization after stenting	15
Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles	15
Assessing the impact of long‐term storage on the quality and integrity of biological specimens in a reproductive biobank	15
Engineering a conduction‐consistent cardiac patch with graphene oxide modified butterfly wings and human pluripotent stem cell‐derived cardiomyocytes	15
BrAIn : A comprehensive artificial intelligence‐based morphology analysis system for brain organoids and neuroscience	15
Spinal cord tissue engineering using human primary neural progenitor cells and astrocytes	15
Machine learning‐based SERS serum detection platform for high‐sensitive and high‐throughput diagnosis of colorectal precancerous lesions	15
Unleashing the potential of mRNA: Overcoming delivery challenges with nanoparticles	15
Engineering pedicled vascularized bladder tissue for functional bladder defect repair	14
Issue Information	14
Reduced glutathione enhances adipose tissue‐derived mesenchymal stem cell engraftment efficiency for liver fibrosis by targeting TGFβ1/SMAD3/NOX4 pathway	14
Establishing a scalable perfusion strategy for the manufacture of CAR‐T cells in stirred‐tank bioreactors using a quality‐by‐design approach	14
Application of polymersomes in membrane protein study and drug discovery: Progress, strategies, and perspectives	14
Use of patient‐derived tumor organoid platform to predict the benefit of postoperative adjuvant chemotherapy for poor responders to neoadjuvant chemoradiotherapy in locally advanced rectal cancer	14
Static magnetic field assisted thawing improves cryopreservation of mouse whole ovaries	14
Near Infrared ‐light responsive chlorin e6 pro‐drug micellar photodynamic therapy for oral cancer	14
Investigational New Drug ‐enabling studies in a human vessel‐chip: Are we there yet?	14
A multifactorial intervertebral disc degeneration model: Integrating inflammation, structural disruption, biomechanical parameters, and neural sensitization	14
Development of a novel glucose‐dendrimer based therapeutic targeting hyperexcitable neurons in neurological disorders	14
Brain‐targeted exosome‐mimetic cell membrane nanovesicles with therapeutic oligonucleotides elicit anti‐tumor effects in glioblastoma animal models	14
The novel hyaluronic acid granular hydrogel attenuates osteoarthritis progression by inhibiting the TLR ‐2/ NF‐κB	14
SHEDs and BMSCs exhibit distinct lineage preferences in HUVECs dyna	14
Integrated role of human thymic stromal cells in hematopoietic stem cell extravasation	14
Vascular stiffening in aging females with a hypertension‐induced HIF2A gain‐of‐function mutation	14