Open Life Sciences

Article	Citations
Silver nanoparticles: synthesis, characterisation and biomedical applications	119
Green fabrication of Co and Co3O4 nanoparticles and their biomedical applications: A review	75
Honey in wound healing: An updated review	48
Supplementation of probiotics in water beneficial growth performance, carcass traits, immune function, and antioxidant capacity in broiler chickens	36
Diabetes and COVID-19	28
Antifungal activity of selected volatile essential oils against Penicillium sp.	27
The aspects of microbial biomass use in the utilization of selected waste from the agro-food industry	22
Functional divergence and adaptive selection of KNOX gene family in plants	19
Aberrant expression of microRNA-132-3p and microRNA-146a-5p in Parkinson’s disease patients	18
CircHIPK3/miR-381-3p axis modulates proliferation, migration, and glycolysis of lung cancer cells by regulating the AKT/mTOR signaling pathway	17
Research progress on the mechanism of orexin in pain regulation in different brain regions	16
Phytoremediation of pollutants from wastewater: A concise review	16
Investigating microplastics and potentially toxic elements contamination in canned Tuna, Salmon, and Sardine fishes from Taif markets, KSA	16
Long non-coding RNA NEAT1 mediates MPTP/MPP+-induced apoptosis via regulating the miR-124/KLF4 axis in Parkinson’s disease	14
MiR-223-3p regulates cell viability, migration, invasion, and apoptosis of non-small cell lung cancer cells by targeting RHOB	14
Dietary food additive monosodium glutamate with or without high-lipid diet induces spleen anomaly: A mechanistic approach on rat model	14
Functional constituents of plant-based foods boost immunity against acute and chronic disorders	14
Technological and antioxidant properties of proteins obtained from waste potato juice	14
Recombinant Bacteroides fragilis enterotoxin-1 (rBFT-1) promotes proliferation of colorectal cancer via CCL3-related molecular pathways	13
Concanavalin A-induced autoimmune hepatitis model in mice: Mechanisms and future outlook	13
Automatic detection and segmentation of adenomatous colorectal polyps during colonoscopy using Mask R-CNN	13
LncRNA PVT1 promotes cervical cancer progression by sponging miR-503 to upregulate ARL2 expression	13
Lnc-PICSAR contributes to cisplatin resistance by miR-485-5p/REV3L axis in cutaneous squamous cell carcinoma	13
Effects of heavy metals on bacterial community surrounding Bijiashan mining area located in northwest China	13
Aberrant expression of PI3K/AKT signaling is involved in apoptosis resistance of hepatocellular carcinoma	12

MiR-489-3p inhibits cell proliferation, migration, and invasion, and induces apoptosis, by targeting the BDNF-mediated PI3K/AKT pathway in glioblastoma	12
Protocatechuic acid attenuates cerebral aneurysm formation and progression by inhibiting TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms in experimental rats	12
Upregulation of miR-150-5p alleviates LPS-induced inflammatory response and apoptosis of RAW264.7 macrophages by targeting Notch1	12
Progress in research on the role of fibrinogen in lung cancer	12
Human Dental Pulp Stem Cells Exhibit Osteogenic Differentiation Potential	12
LncRNA SNHG15 contributes to doxorubicin resistance of osteosarcoma cells through targeting the miR-381-3p/GFRA1 axis	11
Modeling the effect of heat treatment on fatty acid composition in home-made olive oil preparations	11
Metabolic profiling of fatty acids in Tripterygium wilfordii multiglucoside- and triptolide-induced liver-injured rats	11
Studying of the promotion mechanism of Bacillus subtilis QM3 on wheat seed germination based on β-amylase	11
Biosurfactant production by a Bacillus megaterium strain	11
Blocking circ_UBR4 suppressed proliferation, migration, and cell cycle progression of human vascular smooth muscle cells in atherosclerosis	11
Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway	11
An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli	10
Inhibition of lncRNA LINC00461/miR-216a/aquaporin 4 pathway suppresses cell proliferation, migration, invasion, and chemoresistance in glioma	10
Long noncoding RNA FTX ameliorates hydrogen peroxide-induced cardiomyocyte injury by regulating the miR-150/KLF13 axis	10
Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities	10
circTLK1 facilitates the proliferation and metastasis of renal cell carcinoma by regulating miR-495-3p/CBL axis	10
WDR74 promotes proliferation and metastasis in colorectal cancer cells through regulating the Wnt/β-catenin signaling pathway	9
miR-339-3p regulated acute pancreatitis induced by caerulein through targeting TNF receptor-associated factor 3 in AR42J cells	9
Lipopolysaccharides promote pulmonary fibrosis in silicosis through the aggravation of apoptosis and inflammation in alveolar macrophages	9
The molecular mechanisms underlying arecoline-induced cardiac fibrosis in rats	9
Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development	9
Silencing XIST mitigated lipopolysaccharide (LPS)-induced inflammatory injury in human lung fibroblast WI-38 cells through modulating miR-30b-5p/CCL16 axis and TLR4/NF-κB signaling pathway	9
MiR-30c-5p/ROCK2 axis regulates cell proliferation, apoptosis and EMT via the PI3K/AKT signaling pathway in HG-induced HK-2 cells	9
Bacteriospermia – A formidable player in male subfertility	9
Advanced glycation end product levels were correlated with inflammation and carotid atherosclerosis in type 2 diabetes patients	9
Two new inflammatory markers related to the CURB-65 score for disease severity in patients with community-acquired pneumonia: The hypersensitive C-reactive protein to albumin ratio and fibrinogen to a	9
CircSAMD4A contributes to cell doxorubicin resistance in osteosarcoma by regulating the miR-218-5p/KLF8 axis	9
Circ_001569 regulates FLOT2 expression to promote the proliferation, migration, invasion and EMT of osteosarcoma cells through sponging miR-185-5p	9
Application of exogenous auxin and gibberellin regulates the bolting of lettuce (Lactuca sativa L.)	9
CTRP9 protects against MIA-induced inflammation and knee cartilage damage by deactivating the MAPK/NF-κB pathway in rats with osteoarthritis	9
Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis	9
Diversity of microbiota in Slovak summer ewes’ cheese “Bryndza”	8
Scutellarin-induced A549 cell apoptosis depends on activation of the transforming growth factor-β1/smad2/ROS/caspase-3 pathway	8
Circ_0084043 promotes cell proliferation and glycolysis but blocks cell apoptosis in melanoma via circ_0084043-miR-31-KLF3 axis	8
Investigation of bioactivities of Taxus chinensis, Taxus cuspidata, and Taxus × media by gas chromatography-mass spectrometry	8
miR-338-3p inhibits cell growth, invasion, and EMT process in neuroblastoma through targeting MMP-2	8
A review of the current state of the computer-aided diagnosis (CAD) systems for breast cancer diagnosis	8
MiR-203-3p inhibits the oxidative stress, inflammatory responses and apoptosis of mice podocytes induced by high glucose through regulating Sema3A expression	8
Ropivacaine inhibits proliferation, migration, and invasion while inducing apoptosis of glioma cells by regulating the SNHG16/miR-424-5p axis	7
In vitro induction and characterisation of tetraploid drumstick tree (Moringa oleifera Lam.)	7
Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis	7
Effects of organic materials on soil bacterial community structure in long-term continuous cropping of tomato in greenhouse	7
Anti-obesity effect and mechanism of mesenchymal stem cells influence on obese mice	7
Neuroanatomy of melanocortin-4 receptor pathway in the mouse brain	7
Relationship between blood clots and COVID-19 vaccines: A literature review	7
Testosterone aggravates cerebral vascular injury by reducing plasma HDL levels	7
Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in rats	7
Influence of inoculation with Lactobacillus on fermentation, production of 1,2-propanediol and 1-propanol as well as Maize silage aerobic stability	7
microRNA-9-5p protects liver sinusoidal endothelial cell against oxygen glucose deprivation/reperfusion injury	7

Long non-coding RNA LINC00704 promotes cell proliferation, migration, and invasion in papillary thyroid carcinoma via miR-204-5p/HMGB1 axis	7
Effects of Bacillus megaterium on growth performance, serum biochemical parameters, antioxidant capacity, and immune function in suckling calves	7
Identification of rice leaf diseases and deficiency disorders using a novel DeepBatch technique	7
Mechanisms of circular RNA circ_0066147 on pancreatic cancer progression	6
FTO gene expression in diet-induced obesity is downregulated by Solanum fruit supplementation	6
Circ_0091579 enhances the malignancy of hepatocellular carcinoma via miR-1287/PDK2 axis	6
Long non-coding RNA SNHG3 accelerates progression in glioma by modulating miR-384/HDGF axis	6
Vitamin D deficiency and cardiovascular risk in type 2 diabetes population	6
Role of MMP-2 and CD147 in kidney fibrosis	6
Morphological structures and histochemistry of roots and shoots in Myricaria laxiflora (Tamaricaceae)	6
Comparative analysis of the SPL gene family in five Rosaceae species: Fragaria vesca, Malus domestica, Prunus persica, Rubus occidentalis, and Pyrus pyrifolia	6
Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress	6
LINC00202 promotes retinoblastoma progression by regulating cell proliferation, apoptosis, and aerobic glycolysis through miR-204-5p/HMGCR axis	6
Abnormal methylation caused by folic acid deficiency in neural tube defects	6
TEAD4 is a novel independent predictor of prognosis in LGG patients with IDH mutation	6
Potential prognostic markers and significant lncRNA–mRNA co-expression pairs in laryngeal squamous cell carcinoma	6
Novel predictor of the occurrence of DKA in T1DM patients without infection: A combination of neutrophil/lymphocyte ratio and white blood cells	6
lncRNA myocardial infarction-associated transcript (MIAT) knockdown alleviates LPS-induced chondrocytes inflammatory injury via regulating miR-488-3p/sex determining region Y-related HMG-box 11 (SOX11	6
Study on the optimal antagonistic effect of a bacterial complex against Monilinia fructicola in peach	6
Hydroxysafflor yellow A improved retinopathy via Nrf2/HO-1 pathway in rats	6
Downregulation of circ_0037655 impedes glioma formation and metastasis via the regulation of miR-1229-3p/ITGB8 axis	6
Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis	6
CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression	6
SOX4 promotes high-glucose-induced inflammation and angiogenesis of retinal endothelial cells by activating NF-κB signaling pathway	6
Effects of chemical-based fertilizer replacement with biochar-based fertilizer on albic soil nutrient content and maize yield	6
Toxic effect of three imidazole ionic liquids on two terrestrial plants	6
Effect of food processing on the antioxidant activity of flavones from Polygonatum odoratum (Mill.) Druce	6
Clinical significance of activated Wnt/β-catenin signaling in apoptosis inhibition of oral cancer	6
LncRNA SNHG15 regulates osteosarcoma progression in vitro and in vivo via sponging miR-346 and regulating TRAF4 expression	6
NR4A1 inhibits the epithelial–mesenchymal transition of hepatic stellate cells: Involvement of TGF-β–Smad2/3/4–ZEB signaling	6
Changes in the fecal microbiome of the Yangtze finless porpoise during a short-term therapeutic treatment	5
miR-378a-3p regulates glioma cell chemosensitivity to cisplatin through IGF1R	5
Composition of low-molecular-weight glutenin subunits in common wheat (Triticum aestivum L.) and their effects on the rheological properties of dough	5
Knockdown of DDX46 inhibits trophoblast cell proliferation and migration through the PI3K/Akt/mTOR signaling pathway in preeclampsia	5
Relationship of Gensini score with retinal vessel diameter and arteriovenous ratio in senile CHD	5
Knockdown of TUG1 rescues cardiomyocyte hypertrophy through targeting the miR-497/MEF2C axis	5
TGF-β1-overexpressing mesenchymal stem cells reciprocally regulate Th17/Treg cells by regulating the expression of IFN-γ	5
miR-299-3p suppresses cell progression and induces apoptosis by downregulating PAX3 in gastric cancer	5
mNGS facilitates the accurate diagnosis and antibiotic treatment of suspicious critical CNS infection in real practice: A retrospective study	5
Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study	5
Effects of Loofah cylindrica extract on learning and memory ability, brain tissue morphology, and immune function of aging mice	5
The significance of PAK4 in signaling and clinicopathology: A review	5
Lidocaine has antitumor effect on hepatocellular carcinoma via the circ_DYNC1H1/miR-520a-3p/USP14 axis	5
Genome-wide identification of MAPK family genes and their response to abiotic stresses in tea plant (Camellia sinensis)	5
Identification of leaf rust resistance genesLr34andLr46in common wheat (Triticum aestivumL. ssp.aestivum) lines of different origin using multiplex PCR	5
3,4-Dihydroxyphenylethanol ameliorates lipopolysaccharide-induced septic cardiac injury in a murine model	5
Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells’ maturation and function	5
Preparation of konjac oligoglucomannans with different molecular weights and their in vitro and in vivo antioxidant activities	5
Long noncoding RNA TUG1 regulates degradation of chondrocyte extracellular matrix via miR-320c/MMP-13 axis in osteoarthritis	5
T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology	5
PCR-detectable Candida DNA exists a short period in the blood of systemic candidiasis murine model	5
Coexisting flavonoids and administration route effect on pharmacokinetics of Puerarin in MCAO rats	4
Age-related changes in peripheral T-cell subpopulations in elderly individuals: An observational study	4
The effects of yam gruel on lowering fasted blood glucose in T2DM rats	4
The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia	4
Application of culture, PCR, and PacBio sequencing for determination of microbial composition of milk from subclinical mastitis dairy cows of smallholder farms	4
Biocompatibility and osteointegration capability of β-TCP manufactured by stereolithography 3D printing: In vitro study	4
Genome-wide identification and expression analysis of CPP-like gene family in Triticum aestivum L. under different hormone and stress conditions	4
Functional conservation and divergence in plant-specific GRF gene family revealed by sequences and expression analysis	4
Identifying two pathogenic variants in a patient with pigmented paravenous retinochoroidal atrophy	4
Characterization of GMPP from Dendrobium huoshanense yielding GDP-D-mannose	4
Neurotrophin-3 accelerates reendothelialization through inducing EPC mobilization and homing	4
Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning	4
Seasonal succession of bacterial communities in cultured Caulerpa lentillifera detected by high-throughput sequencing	4
Down-regulation of IGHG1 enhances Protoporphyrin IX accumulation and inhibits hemin biosynthesis in colorectal cancer by suppressing the MEK-FECH axis	4
Circ_0013359 facilitates the tumorigenicity of melanoma by regulating miR-136-5p/RAB9A axis	4
Preliminary screening of microplastic contamination in different marine fish species of Taif market, Saudi Arabia	4
Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide	4
Hyperhomocysteinemia exacerbates ischemia-reperfusion injury-induced acute kidney injury by mediating oxidative stress, DNA damage, JNK pathway, and apoptosis	4
LINC00665 regulates hepatocellular carcinoma by modulating mRNA via the m6A enzyme	4
lncRNA NEAT1 regulates CYP1A2 and influences steroid-induced necrosis	4
TAK-242, a toll-like receptor 4 antagonist, against brain injury by alleviates autophagy and inflammation in rats	4
Circ_WWC3 overexpression decelerates the progression of osteosarcoma by regulating miR-421/PDE7B axis	4
Relationship of FTO gene variations with NAFLD risk in Chinese men	4
Inhibition of ADAM10 ameliorates doxorubicin-induced cardiac remodeling by suppressing N-cadherin cleavage	4
Immunoregulation of synovial macrophages for the treatment of osteoarthritis	4
circ_CHFR regulates ox-LDL-mediated cell proliferation, apoptosis, and EndoMT by miR-15a-5p/EGFR axis in human brain microvessel endothelial cells	4
Twig biomass allocation of Betula platyphylla in different habitats in Wudalianchi Volcano, northeast China	4
Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso	4
Relationship between hemodynamic parameters and portal venous pressure in cirrhosis patients with portal hypertension	4

GeneXpert Technology for the diagnosis of HIV-associated tuberculosis: Is scale-up worth it?	4
Medical imaging in rheumatoid arthritis: A review on deep learning approach	4
Response of benthic invertebrate assemblages to seasonal and habitat condition in the Wewe River, Ashanti region (Ghana)	4
6-Phosphogluconate dehydrogenase inhibition arrests growth and induces apoptosis in gastric cancer via AMPK activation and oxidative stress	4
Genetic susceptibility to high myopia in Han Chinese population	4
Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?	4
MiR-4328 inhibits proliferation, metastasis and induces apoptosis in keloid fibroblasts by targeting BCL2 expression	4
Investigation of molecular regulation mechanism under the pathophysiology of subarachnoid hemorrhage	4
An efficient protocol for regenerating shoots from paper mulberry (Broussonetia papyrifera) leaf explants	4
Ubiquitin-conjugating enzyme E2T promotes tumor stem cell characteristics and migration of cervical cancer cells by regulating the GRP78/FAK pathway	3
Immunosuppressive treatment for idiopathic membranous nephropathy: An updated network meta-analysis	3
Sorafenib inhibits ovarian cancer cell proliferation and mobility and induces radiosensitivity by targeting the tumor cell epithelial–mesenchymal transition	3
Effects of glucose and osmotic pressure on the proliferation and cell cycle of human chorionic trophoblast cells	3
Osteogenic differentiation of periodontal membrane stem cells in inflammatory environments	3
Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood–brain barrier during kainic acid-induced brain damage	3
Characterization of intestinal microbiota and serum metabolites in patients with mild hepatic encephalopathy	3
Molecular characterization and phylogenetic studies of Echinococcus granulosus and Taenia multiceps coenurus cysts in slaughtered sheep in Saudi Arabia	3
Melatonin enhances salt tolerance in sorghum by modulating photosynthetic performance, osmoregulation, antioxidant defense, and ion homeostasis	3
Effects of inorganic and organic selenium sources on the growth performance of broilers in China: A meta-analysis	3
Biomedical evaluation of antioxidant properties of lamb meat enriched with iodine and selenium	3
Babesia microti-induced fulminant sepsis in an immunocompromised host: A case report and the case-specific literature review	3
Analysis of bacterial community structure of Fuzhuan tea with different processing techniques	3
Meta-analysis of cancer risk among end stage renal disease undergoing maintenance dialysis	3
Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus	3
Artificial intelligence and internet of things oriented sustainable precision farming: Towards modern agriculture	3
The role of erythrocytes and erythroid progenitor cells in tumors	3
Identification of active compounds in Ophiopogonis Radix from different geographical origins by UPLC-Q/TOF-MS combined with GC-MS approaches	3
The prognostic and predictive value of platelet parameters in diabetic and nondiabetic patients with sudden sensorineural hearing loss	3
Tissue culture and rapid propagation technology for Gentiana rhodantha	3
A two-microRNA signature predicts the progression of male thyroid cancer	3
Effect of addition of dried potato pulp on selected quality characteristics of shortcrust pastry cookies	3
Expression of CDK9 in endometrial cancer tissues and its effect on the proliferation of HEC-1B	3
Isolation of microglia from retinas of chronic ocular hypertensive rats	3
Elevated IL-35 level and iTr35 subset increase the bacterial burden and lung lesions in Mycobacterium tuberculosis-infected mice	3
Regulation of miR-30b in cancer development, apoptosis, and drug resistance	3
Isoimperatorin alleviates lipopolysaccharide-induced periodontitis by downregulating ERK1/2 and NF-κB pathways	3
The entire chloroplast genome sequence of Asparagus cochinchinensis and genetic comparison to Asparagus species	3
Long non-coding RNA NEAT1 promotes angiogenesis in hepatoma carcinoma via the miR-125a-5p/VEGF pathway	3
CD11b is involved in coxsackievirus B3-induced viral myocarditis in mice by inducing Th17 cells	3
Long non-coding RNA HOXB-AS1 is a prognostic marker and promotes hepatocellular carcinoma cells’ proliferation and invasion	3
Red blood cell distribution width-standard deviation but not red blood cell distribution width-coefficient of variation as a potential index for the diagnosis of iron-deficiency anemia in mid-pregnanc	3
Malignant pleural effusion diagnosis and therapy	3
Effects of the interaction of Notch and TLR4 pathways on inflammation and heart function in septic heart	3
Clonal diversity of the B cell receptor repertoire in patients with coronary in-stent restenosis and type 2 diabetes	3
Association study of CLDN14 variations in patients with kidney stones	3
Inflammation-related signaling pathways in tendinopathy	3
Characterization and evaluation of anti-Salmonella enteritidisactivity of indigenous probiotic lactobacilli in mice	3
Downregulation of STOX1 is a novel prognostic biomarker for glioma patients	3
Transcriptome analysis of resistance mechanism to potato wart disease	3
Identification of novel drought-responsive miRNA regulatory network of drought stress response in common vetch (Vicia sativa)	3
Agronomic and economic performance of mung bean (Vigna radiata L.) varieties in response to rates of blended NPS fertilizer in Kindo Koysha district, Southern Ethiopia	3
MiR-146b-3p protects against AR42J cell injury in cerulein-induced acute pancreatitis model through targeting Anxa2	3
ADHFE1 is a correlative factor of patient survival in cancer	3
Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model	3
ACTB and GAPDH appear at multiple SDS-PAGE positions, thus not suitable as reference genes for determining protein loading in techniques like Western blotting	3
IL-17 in osteoarthritis: A narrative review	3
Identification of winter wheat pests and diseases based on improved convolutional neural network	3
In-field screening for host plant resistance to Delia radicum and Brevicoryne brassicae within selected rapeseed cultivars and new interspecific hybrids	3
Systemic investigation of inetetamab in combination with small molecules to treat HER2-overexpressing breast and gastric cancers	3
Predators of the giant pine scale, Marchalina hellenica (Gennadius 1883; Hemiptera: Marchalinidae), out of its natural range in Turkey	3
The impedance analysis of small intestine fusion by pulse source	3
Effects of miR-185-5p on replication of hepatitis C virus	3