Open Life Sciences

Article	Citations
Comparison of axon extension: PTFE versus PLA formed by a 3D printer	61
Role of cerebellar cortex in associative learning and memory in guinea pigs	32
Characterization of intestinal microbiota and serum metabolites in patients with mild hepatic encephalopathy	28
Microbial diversity of milk ghee in southern Gansu and its effect on the formation of ghee flavor compounds	24
Elevated IL-35 level and iTr35 subset increase the bacterial burden and lung lesions in Mycobacterium tuberculosis-infected mice	24
Preparation and evaluation of LA-PEG-SPION, a targeted MRI contrast agent for liver cancer	24
Dietary food additive monosodium glutamate with or without high-lipid diet induces spleen anomaly: A mechanistic approach on rat model	23
Bioinformatics network analyses of growth differentiation factor 11	22
Effectiveness of the treatment of depression associated with cancer and neuroimaging changes in depression-related brain regions in patients treated with the mediator-deuterium acupuncture method	19
PHB2 alleviates retinal pigment epithelium cell fibrosis by suppressing the AGE–RAGE pathway	18
Combination of a bronchogenic cyst in the thoracic spinal canal with chronic myelocytic leukemia	18
Predictive analytics in smart healthcare for child mortality prediction using a machine learning approach	17
An unusual ectopic thymoma clonal evolution analysis: A case report	15
Comparing the differences of prokaryotic microbial community between pit walls and bottom from Chinese liquor revealed by 16S rRNA gene sequencing	15
LL37-mtDNA regulates viability, apoptosis, inflammation, and autophagy in lipopolysaccharide-treated RLE-6TN cells by targeting Hsp90aa1	14
Study on the genetic damage caused by cadmium sulfide quantum dots in human lymphocytes	14
Low levels of sex hormone-binding globulin predict an increased breast cancer risk and its underlying molecular mechanisms	14
Calcifying nanoparticles initiate the calcification process of mesenchymal stem cells in vitro through the activation of the TGF-β1/Smad signaling pathway and promote the decay of echinococcosi	14
Adoption value of support vector machine algorithm-based computed tomography imaging in the diagnosis of secondary pulmonary fungal infections in patients with malignant hematological disorders	14
Application of CRISPR/Cas gene editing for infectious disease control in poultry	14
Identifying two pathogenic variants in a patient with pigmented paravenous retinochoroidal atrophy	14
Identification of KDM4C as a gene conferring drug resistance in multiple myeloma	14
Identification of metabolic genes for the prediction of prognosis and tumor microenvironment infiltration in early-stage non-small cell lung cancer	13
Potential regulatory mechanism of TNF-α/TNFR1/ANXA1 in glioma cells and its role in glioma cell proliferation	13
Development of alkaline phosphatase-scFv and its use for one-step enzyme-linked immunosorbent assay for His-tagged protein detection	13

Immunological responses of septic rats to combination therapy with thymosin α1 and vitamin C	12
Effects of NM23 transfection of human gastric carcinoma cells in mice	12
Interaction between the PI3K/AKT pathway and mitochondrial autophagy in macrophages and the leukocyte count in rats with LPS-induced pulmonary infection	12
Isolation, identification, and drug resistance of a partially isolated bacterium from the gill of Siniperca chuatsi	12
Oral nifedipine and phytosterol, intravenous nicardipine, and oral nifedipine only: Three-arm, retrospective, cohort study for management of severe preeclampsia	11
Metastasis from small cell lung cancer to ovary: A case report	11
Association of ADRB2 gene polymorphisms and intestinal microbiota in Chinese Han adolescents	11
Association between TGF-β1 and β-catenin expression in the vaginal wall of patients with pelvic organ prolapse	10
Bioinformatics, expression analysis, and functional verification of allene oxide synthase gene HvnAOS1 and HvnAOS2 in qingke	10
Clusterin activates the heat shock response via the PI3K/Akt pathway to protect cardiomyocytes from high-temperature-induced apoptosis	10
Impact of novel herbicide based on synthetic auxins and ALS inhibitor on weed control	10
Hesperidin and its zinc(ii) complex enhance osteoblast differentiation and bone formation: In vitro and in vivo evaluations	10
ErbB4 promotes M2 activation of macrophages in idiopathic pulmonary fibrosis	10
Knockdown of USP7 alleviates atherosclerosis in ApoE-deficient mice by regulating EZH2 expression	9
Knockdown of DLK4 inhibits non-small cell lung cancer tumor growth by downregulating CKS2	9
Effect of periostin on bone metabolic and autophagy factors during tooth eruption in mice	9
Liupao tea aqueous extract alleviates dextran sulfate sodium-induced ulcerative colitis in rats by modulating the gut microbiota	9
Genetic alterations of KRAS and TP53 in intrahepatic cholangiocarcinoma associated with poor prognosis	9
Protein Z modulates the metastasis of lung adenocarcinoma cells	9
A case report of diagnosis and dynamic monitoring of Listeria monocytogenes meningitis with NGS	8
Effects of KCa channels on biological behavior of trophoblasts	8
Hydroxysafflor yellow A improved retinopathy via Nrf2/HO-1 pathway in rats	8
Small breast epithelial mucin as a useful prognostic marker for breast cancer patients	8
Hairpin in a haystack: In silico identification and characterization of plant-conserved microRNA in Rafflesiaceae	8
Characterization and evaluation of anti-Salmonella enteritidisactivity of indigenous probiotic lactobacilli in mice	8
Primary pulmonary synovial sarcoma in the bronchial cavity: A case report	8
One case of iodine-125 therapy – A new minimally invasive treatment of intrahepatic cholangiocarcinoma	8
Haplo-hematopoietic stem cell transplantation and immunoradiotherapy for severe aplastic anemia complicated with nasopharyngeal carcinoma: A case report	8
Significant elevated CXCL14 and decreased IL-39 levels in patients with tuberculosis	7
Metformin mitigates osteoarthritis progression by modulating the PI3K/AKT/mTOR signaling pathway and enhancing chondrocyte autophagy	7
Current research and evidence gaps on placental development in iron deficiency anemia	7
A case of Trousseau syndrome: Screening, detection and complication	7
A biomedical decision support system for meta-analysis of bilateral upper-limb training in stroke patients with hemiplegia	7
Proteome differences of dental stem cells between permanent and deciduous teeth by data-independent acquisition proteomics	7
A case of bloodstream infection caused by Neisseria gonorrhoeae	7
Role of menopausal hormone therapy in the prevention of postmenopausal osteoporosis	7
Bamboo charcoal affects soil properties and bacterial community in tea plantations	7
Retraction to “Protocatechuic acid attenuates cerebral aneurysm formation and progression by inhibiting TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms in experimental rats”	7
Guesstimate of thymoquinone diversity in Nigella sativa L. genotypes and elite varieties collected from Indian states using HPTLC technique	7
Incidence of different pressure patterns of spinal cerebellar ataxia and analysis of imaging and genetic diagnosis	7
Effect of the genetic mutant G71R in uridine diphosphate-glucuronosyltransferase 1A1 on the conjugation of bilirubin	6
BTBD10 inhibits glioma tumorigenesis by downregulating cyclin D1 and p-Akt	6
Effects of maternal calcium and protein intake on the development and bone metabolism of offspring mice	6
Lacunar infarction aggravates the cognitive deficit in the elderly with white matter lesion	6
Geometric basis of action potential of skeletal muscle cells and neurons	6
Novel compound heterozygous mutations in TELO2 in an infant with You-Hoover-Fong syndrome: A case report and literature review	6
Correlation analysis between semen routine parameters and sperm DNA fragmentation index in patients with semen non-liquefaction: A retrospective study	6
Comprehensive phytochemical and toxicological analysis of Chenopodium ambrosioides (L.) fractions	6
Long non-coding RNAs in bone formation: Key regulators and therapeutic prospects	6
Effects of glucose and osmotic pressure on the proliferation and cell cycle of human chorionic trophoblast cells	6

Effect of berrycactus fruit (Myrtillocactus geometrizans) on glutamate, glutamine, and GABA levels in the frontal cortex of rats fed with a high-fat diet	6
The G protein-coupled receptor-related gene signatures for predicting prognosis and immunotherapy response in bladder urothelial carcinoma	6
Inflammation-related signaling pathways in tendinopathy	6
15-Lipoxygenase-2 deficiency induces foam cell formation that can be restored by salidroside through the inhibition of arachidonic acid effects	6
Phylogenetic analysis of promoter regions of human Dolichol kinase (DOLK) and orthologous genes using bioinformatics tools	6
Quantitative immunohistochemistry analysis of breast Ki67 based on artificial intelligence	6
Differences in the flavonoid composition of the leaves, fruits, and branches of mulberry are distinguished based on a plant metabolomics approach	6
Analysis of genetic characteristics of 436 children with dysplasia and detailed analysis of rare karyotype	6
Exploring the diagnostic markers of essential tremor: A study based on machine learning algorithms	6
Association between single-nucleotide polymorphisms of NKX2.5 and congenital heart disease in Chinese population: A meta-analysis	6
LARP1 knockdown inhibits cultured gastric carcinoma cell cycle progression and metastatic behavior	6
Influence of solvent-free extraction of fish oil from catfish (Clarias magur) heads using a Taguchi orthogonal array design: A qualitative and quantitative approach	6
Chlorate-induced molecular floral transition revealed by transcriptomes	6
Comparison of immunotherapy combined with stereotactic radiotherapy and targeted therapy for patients with brain metastases: A systemic review and meta-analysis	6
Application of the integrated airway humidification device enhances the humidification effect of the rabbit tracheotomy model	6
Case report of atypical undernutrition of hypoproteinemia type	6
Evaluation of brain nerve function in ICU patients with Delirium by deep learning algorithm-based resting state MRI	5
Long-term administration of morphine specifically alters the level of protein expression in different brain regions and affects the redox state	5
Activation of hypermethylated P2RY1 mitigates gastric cancer by promoting apoptosis and inhibiting proliferation	5
The expression of epidermal growth factor receptor 2 and its relationship with tumor-infiltrating lymphocytes and clinical pathological features in breast cancer patients	5
Corrigendum to “Utilization of convolutional neural networks to analyze microscopic images for high-throughput screening of mesenchymal stem cells”	5
Effects of Piriformospora indica and arbuscular mycorrhizal fungus on growth and physiology of Moringa oleifera under low-temperature stress	5
The role of rapamycin in the PINK1/Parkin signaling pathway in mitophagy in podocytes	5
Adiponectin inhibits TGF-β1-induced skin fibroblast proliferation and phenotype transformation via the p38 MAPK signaling pathway	5
Prostatitis as initial manifestation of Chlamydia psittaci pneumonia diagnosed by metagenome next-generation sequencing: A case report	5
Fractalkine modulates pulmonary angiogenesis and tube formation by modulating CX3CR1 and growth factors in PVECs	5
Retraction to “A data mining technique for detecting malignant mesothelioma cancer using multiple regression analysis”	5
ZAG promotes colorectal cancer cell proliferation and epithelial–mesenchymal transition by promoting lipid synthesis	5
Identification of iron metabolism-related genes as diagnostic signatures in sepsis by blood transcriptomic analysis	5
Downregulation of RIP3 ameliorates the left ventricular mechanics and function after myocardial infarctionviamodulating NF-κB/NLRP3 pathway	5
Review on role of honey in disease prevention and treatment through modulation of biological activities	5
Case of nasopharyngeal tuberculosis complicated with cervical lymph node and pulmonary tuberculosis	5
Exploring antioxidant strategies in the pathogenesis of ALS	5
Exploring the conformational dynamics and thermodynamics of EGFR S768I and G719X + S768I mutations in non-small cell lung cancer: An in silico approaches	5
β-Hydroxybutyrate upregulates FGF21 expression through inhibition of histone deacetylases in hepatocytes	5
Helicobacter pylori causes gastric dysbacteriosis in chronic gastritis patients	5
Analysis of bacterial community structure of Fuzhuan tea with different processing techniques	5
Collagen changes in rabbit conjunctiva after conjunctival crosslinking	5
Neutrophilia with subclinical Cushing’s disease: A case report and literature review	5
Application and teaching of computer molecular simulation embedded technology and artificial intelligence in drug research and development	4
Effect of long-term in-row branch covering on soil microorganisms in pear orchards	4
Investigating the impact of wet rendering (solventless method) on PUFA-rich oil from catfish (Clarias magur) viscera	4
The complete chloroplast genome of Gerbera piloselloides (L.) Cass., 1820 (Carduoideae, Asteraceae) and its phylogenetic analysis	4
Electroacupuncture alleviates sciatic nerve injury in sciatica rats by regulating BDNF and NGF levels, myelin sheath degradation, and autophagy	4
IL-11 promotes Ang II-induced autophagy inhibition and mitochondrial dysfunction in atrial fibroblasts	4
Uterine tumor resembling ovarian sex cord tumor with extensive rhabdoid differentiation: A case report	4
Macrofungal sporocarp community in the lichen Scots pine forests	4
Severe cumulative skin toxicity during toripalimab combined with vemurafenib following toripalimab alone	4
Knockdown of SHMT2 enhances the sensitivity of gastric cancer cells to radiotherapy through the Wnt/β-catenin pathway	4
Alterations of metabolites related to microbiota–gut–brain axis in plasma of colon cancer, esophageal cancer, stomach cancer, and lung cancer patients	4
Comparison of nutritional value of the wild and cultivated spiny loaches at three growth stages	4
Pathogenic bacteria and treatment resistance in older cardiovascular disease patients with lung infection and risk prediction model	4
Novel rare genetic variants of familial and sporadic pulmonary atresia identified by whole-exome sequencing	4
Crown and diameter structure of purePinus massonianaLamb. forest in Hunan province, China	4
Novel risk prediction models for deep vein thrombosis after thoracotomy and thoracoscopic lung cancer resections, involving coagulation and immune function	4
Association between PAX9 or MSX1 gene polymorphism and tooth agenesis risk: A meta-analysis	4
The entire chloroplast genome sequence of Asparagus cochinchinensis and genetic comparison to Asparagus species	4
Exopolysaccharides from Pseudomonas tolaasii inhibit the growth of Pleurotus ostreatus mycelia	4
Biofertilizer and NPSB fertilizer application effects on nodulation and productivity of common bean (Phaseolus vulgaris L.) at Sodo Zuria, Southern Ethiopia	4
Coexistence of hereditary spherocytosis with SPTB P.Trp1150 gene variant and Gilbert syndrome: A case report and literature review	4
Melatonin enhances salt tolerance in sorghum by modulating photosynthetic performance, osmoregulation, antioxidant defense, and ion homeostasis	4
Isoimperatorin alleviates lipopolysaccharide-induced periodontitis by downregulating ERK1/2 and NF-κB pathways	4
Analysis of MDA, SOD, TAOC, MNCV, SNCV, and TSS scores in patients with diabetes peripheral neuropathy	4
Non-linear associations between cardiovascular metabolic indices and metabolic-associated fatty liver disease: A cross-sectional study in the US population (2017–2020)	4
Impact of SWCNT-conjugated senna leaf extract on breast cancer cells: A potential apoptotic therapeutic strategy	4
BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis	4
Investigation of genotype diversity of 7,804 norovirus sequences in humans and animals of China	4
Reexamination of Aspergillus cristatus phylogeny in dark tea: Characteristics of the mitochondrial genome	4
Application of metagenomic next-generation sequencing technology in the etiological diagnosis of peritoneal dialysis-associated peritonitis	4
Advances in diagnosis and treatment of perimenopausal syndrome	4
Selection and functional identification of Dof genes expressed in response to nitrogen in Populus simonii × Populus nigra	4
Effects of pegylated recombinant human granulocyte colony-stimulating factor on lymphocytes and white blood cells of patients with malignant tumor	4
The altered expression of cytoskeletal and synaptic remodeling proteins during epilepsy	4
IgG4-related disease complicated by PLA2R-associated membranous nephropathy: A case report	3
High-temperature requirement serine protease A2 inhibitor UCF-101 ameliorates damaged neurons in traumatic brain-injured rats by the AMPK/NF-κB pathway	3
Babesia microti-induced fulminant sepsis in an immunocompromised host: A case report and the case-specific literature review	3
Down-regulation of COL1A1 inhibits tumor-associated fibroblast activation and mediates matrix remodeling in the tumor microenvironment of breast cancer	3
Quercetin inhibits cytotoxicity of PC12 cells induced by amyloid-beta 25–35 via stimulating estrogen receptor α, activating ERK1/2, and inhibiting apoptosis	3
Transfer RNA-derived fragment tRF-36 modulates varicose vein progression via human vascular smooth muscle cell Notch signaling	3
Case report: Successful bronchoscopic interventional treatment of endobronchial leiomyomas	3

Surgery, adjuvant immunotherapy plus chemotherapy and radiotherapy for primary malignant melanoma of the parotid gland (PGMM): A case report	3
Rhodococcus equiandBrucellapulmonary mass in immunocompetent: A case report and literature review	3
Comparative transcriptomes reveal molecular mechanisms of apple blossoms of different tolerance genotypes to chilling injury	3
A comparative analysis of dendrometric, macromorphological, and micromorphological characteristics of Pistacia atlantica subsp. atlantica and Pistacia terebinthus in the middle At	3
A novel GNAS mutation in pseudohypoparathyroidism type 1a with articular flexion deformity: A case report	3
Preliminary investigation into the genetic etiology of short stature in children through whole exon sequencing of the core family	3
Tanshinone IIA alleviates chondrocyte apoptosis and extracellular matrix degeneration by inhibiting ferroptosis	3
Study on pecan seed germination influenced by seed endocarp	3
Application of the FLP/LoxP-FRT recombination system to switch the eGFP expression in a model prokaryote	3
Continuous non-adherent culture promotes transdifferentiation of human adipose-derived stem cells into retinal lineage	3
Relationship between CRP gene polymorphisms and ischemic stroke risk: A systematic review and meta-analysis	3
Evaluation of effects of small-incision approach treatment on proximal tibia fracture by deep learning algorithm-based magnetic resonance imaging	3
An optimization method for measuring the stomata in cassava (Manihot esculenta Crantz) under multiple abiotic stresses	3
Silencing circular RNA-friend leukemia virus integration 1 restrained malignancy of CC cells and oxaliplatin resistance by disturbing dyskeratosis congenita 1	3
Research progress on gas signal molecular therapy for Parkinson’s disease	3
Knockdown of G1P3 inhibits cell proliferation and enhances the cytotoxicity of dexamethasone in acute lymphoblastic leukemia	3
Effects of de novo donor-specific Class I and II antibodies on graft outcomes after liver transplantation: A pilot cohort study	3
Effects of exogenous 2,4-epibrassinolide on photosynthetic traits of 53 cowpea varieties under NaCl stress	3
Aberrant pulmonary immune response of obese mice to periodontal infection	3
PEI/MMNs@LNA-542 nanoparticles alleviate ICU-acquired weakness through targeted autophagy inhibition and mitochondrial protection	3
Research progress on the regulation of autophagy in cardiovascular diseases by chemokines	3
Primary retroperitoneal angiosarcoma: A case report	3
Decreased serum TIMP4 levels in patients with rheumatoid arthritis	3
Ezrin promotes esophageal squamous cell carcinoma progression via the Hippo signaling pathway	3
Development and validation of a predictive model for immune-related genes in patients with tongue squamous cell carcinoma	3
The role and mechanism of esketamine in preventing and treating remifentanil-induced hyperalgesia based on the NMDA receptor–CaMKII pathway	3
Suggestions on leading an academic research laboratory group	3
Baculovirus-mediated endostatin and angiostatin activation of autophagy through the AMPK/AKT/mTOR pathway inhibits angiogenesis in hepatocellular carcinoma	3
Effects of different sources of potassium fertiliser on yield, fruit quality and nutrient absorption in “Harward” kiwifruit (Actinidia deliciosa)	3
Early diagnosis for the onset of peri-implantitis based on artificial neural network	3
Multiple organ failure and death caused by Staphylococcus aureus hip infection: A case report	3
Role of circRMRP and circRPL27 in chronic obstructive pulmonary disease	3
Exploring the coupling mode of water and fertilizer for improving growth, fruit quality, and yield of the pear in the arid region	3
Assessment of drought tolerance indices in faba bean genotypes under different irrigation regimes	3
Enhancing faba bean (Vicia faba L.) productivity through establishing the area-specific fertilizer rate recommendation in southwest Ethiopia	3
Neurodegenerative diseases and neuroinflammation-induced apoptosis	3
Understory vegetation diversity patterns of Platycladus orientalis and Pinus elliottii communities in Central and Southern China	3
Effects of heavy metals on bacterial community surrounding Bijiashan mining area located in northwest China	3
Genome-wide identification of MAPK family genes and their response to abiotic stresses in tea plant (Camellia sinensis)	3
Bacteriospermia – A formidable player in male subfertility	3
Experimental study on the optimization of ANM33 release in foam cells	3
NAT10 promotes radiotherapy resistance in non-small cell lung cancer by regulating KPNB1-mediated PD-L1 nuclear translocation	3
Electroacupuncture on GB acupoints improves osteoporosis via the estradiol–PI3K–Akt signaling pathway	3
Erianin alleviates collagen-induced arthritis in mice by inhibiting Th17 cell differentiation	3
Value of brain injury-related indicators based on neural network in the diagnosis of neonatal hypoxic-ischemic encephalopathy	3
Development of an instrument-free and low-cost ELISA dot-blot test to detect antibodies against SARS-CoV-2	3
FTO alleviated the diabetic nephropathy progression by regulating the N6-methyladenosine levels of DACT1	3
Evolution trend of soil fertility in tobacco-planting area of Chenzhou, Hunan Province, China	3
Characteristics and karyotype analysis of a patient with turner syndrome complicated with multiple-site tumors: A case report	3
A review of the current state of the computer-aided diagnosis (CAD) systems for breast cancer diagnosis	3
Therapeutic approaches for liver fibrosis/cirrhosis by targeting pyroptosis	3
PTX3 promotes IVIG resistance-induced endothelial injury in Kawasaki disease by regulating the NF-κB pathway	3
Active legumain promotes invasion and migration of neuroblastoma by regulating epithelial-mesenchymal transition	3
Ten-year anemia as initial manifestation of Castleman disease in the abdominal cavity: A case report	3
Effects of cadmium stress on fruits germination and growth of two herbage species	3