Open Medicine

Papers
(The TQCC of Open Medicine is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)
ArticleCitations
The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae108
Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis95
Identification and validation of autophagy-related genes in SSc68
Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway47
The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial42
Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China37
Construction of a ceRNA network to reveal a vascular invasion associated prognostic model in hepatocellular carcinoma33
Menstrual irregularities associated with COVID-19 vaccines among women in Saudi Arabia: A survey during 202224
Vitamin C and epigenetics: A short physiological overview23
Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study23
β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis22
Mycophenolate mofetil versus cyclophosphamide plus in patients with connective tissue disease-associated interstitial lung disease: Efficacy and safety analysis18
Cimifugin inhibits adipogenesis and TNF-α-induced insulin resistance in 3T3-L1 cells16
Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”16
Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway15
Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics15
Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system14
COVID-19 fear, post-traumatic stress, growth, and the role of resilience14
ALKBH5 inhibits TNF-α-induced apoptosis of HUVECs through Bcl-2 pathway14
lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation13
Amyotrophic lateral sclerosis and delayed onset muscle soreness in light of the impaired blink and stretch reflexes – watch out for Piezo213
Maternal factors for neural tube defects in offspring: An umbrella review13
SETD1A promotes the proliferation and glycolysis of nasopharyngeal carcinoma cells by activating the PI3K/Akt pathway12
Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway12
Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke12
Serpin family A member 1 is an oncogene in glioma and its translation is enhanced by NAD(P)H quinone dehydrogenase 1 through RNA-binding activity12
Huge mucinous cystic neoplasms with adhesion to the left colon: A case report and literature review12
Analysis of clinical characteristics in proximal and distal reflux monitoring among patients with gastroesophageal reflux disease12
Marital status and its correlation with age, race, and gender in prognosis of tonsil squamous cell carcinomas11
Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer11
Epithelial-mesenchymal transition-related genes in coronary artery disease11
Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study11
Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke11
Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques11
Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis11
Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy11
Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns11
Delivery in a vertical birth chair supported by freedom of movement during labor: A randomized control trial10
Tollip promotes hepatocellular carcinoma progression via PI3K/AKT pathway10
The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis10
Clinicopathological characteristics and prognosis of young patients aged ≤45 years old with non-small cell lung cancer10
Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights10
KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF1110
Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke10
ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway10
Retraction of: “SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways”10
Investigating hormesis, aging, and neurodegeneration: From bench to clinics10
CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis10
circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury9
OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations9
Protective effect of ghrelin on intestinal I/R injury in rats9
Overexpression of miR-100-5p inhibits papillary thyroid cancer progression via targeting FZD89
Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction9
Prevalence and antibiogram of bacteria causing urinary tract infection among patients with chronic kidney disease9
Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake9
Mortality associated with Sjögren’s syndrome in the United States in the 1999–2020 period: A multiple cause-of-death study8
Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy8
EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway8
Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis8
Erratum to “lncRNA NORAD promotes lung cancer progression by competitively binding to miR-28-3p with E2F2”8
Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients8
MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE8
Analysis of two-gene signatures and related drugs in small-cell lung cancer by bioinformatics8
Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism8
Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-198
Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy8
A single oral administration of flavanols enhances short-term memory in mice along with increased brain-derived neurotrophic factor8
A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma8
Sex-specific associations of sex hormone binding globulin and risk of bladder cancer8
Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility8
AS-IV enhances the antitumor effects of propofol in NSCLC cells by inhibiting autophagy8
A low serum uric acid concentration predicts a poor prognosis in adult patients with candidemia8
lncRNA WT1-AS attenuates hypoxia/ischemia-induced neuronal injury during cerebral ischemic stroke via miR-186-5p/XIAP axis8
Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS98
Repeated partial splenic artery embolization for hypersplenism improves platelet count8
Erratum to “Bladder-embedded ectopic intrauterine device with calculus”8
Usefulness of close surveillance for rectal cancer patients after neoadjuvant chemoradiotherapy7
Gene signature to predict prognostic survival of hepatocellular carcinoma7
Analysis of serum metabolomics in patients with different types of chronic heart failure7
Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells7
Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway7
Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study7
A comparative study on the overlapping effects of clinically applicable therapeutic interventions in patients with central nervous system damage7
Surgical management and outcomes of traumatic global brachial plexus injury: A concise review and our center approach7
Retraction to “miR-519d downregulates LEP expression to inhibit preeclampsia development”7
Unusual neurological manifestations of bilateral medial medullary infarction: A case report7
Comparison of the ability of newly inflammatory markers to predict complicated appendicitis7
NK-cell dysfunction of acute myeloid leukemia in relation to the renin–angiotensin system and neurotransmitter genes7
Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis7
Clinical features and management of lymphoepithelial cyst7
Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block7
Delayed femoral vein ligation reduces operative time and blood loss during hip disarticulation in patients with extremity tumors7
Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation7
Ureteroiliac fistula after oncological surgery: Case report and review of the literature7
Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”7
Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”7
Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL27
Variations in sexual function after laparoendoscopic single-site hysterectomy in women with benign gynecologic diseases7
Clinical significance of serum MBD3 detection in girls with central precocious puberty6
Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis6
Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma6
Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling6
Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking6
Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature6
Prognostic value of nicotinamide N-methyltransferase in human cancers: Evidence from a meta-analysis and database validation6
Is there any effect on imprinted genes H19, PEG3, and SNRPN during AOA?6
Physiological and modulatory role of thioredoxins in the cellular function6
Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study6
Ebselen: A promising therapy protecting cardiomyocytes from excess iron in iron-overloaded thalassemia patients6
Immunohistochemical distribution of Bcl-2 and p53 apoptotic markers in acetamiprid-induced nephrotoxicity6
Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study6
Exendin-4 regulates the MAPK and WNT signaling pathways to alleviate the osteogenic inhibition of periodontal ligament stem cells in a high glucose environment6
Radiation increases COL1A1, COL3A1, and COL1A2 expression in breast cancer6
Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer6
The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study6
Role of ICAM-1 in triple-negative breast cancer6
Role of Jumonji domain-containing protein D3 and its inhibitor GSK-J4 in Hashimoto’s thyroiditis6
Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation6
Effect of gestational diabetes mellitus on lipid profile: A systematic review and meta-analysis6
Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?6
Two case reports of maturity-onset diabetes of the young type 3 caused by the hepatocyte nuclear factor 1α gene mutation6
α-Hederin regulates macrophage polarization to relieve sepsis-induced lung and liver injuries in mice6
Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ6
Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey6
Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma6
Targeting PTBP1 blocks glutamine metabolism to improve the cisplatin sensitivity of hepatocarcinoma cells through modulating the mRNA stability of glutaminase6
Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section6
Vitamin D protects intestines from liver cirrhosis-induced inflammation and oxidative stress by inhibiting the TLR4/MyD88/NF-κB signaling pathway6
Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways6
A prognostic signature based on seven T-cell-related cell clustering genes in bladder urothelial carcinoma6
Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis6
Silencing of long noncoding RNA MIAT inhibits the viability and proliferation of breast cancer cells by promoting miR-378a-5p expression6
Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis5
The function of Foxp1 represses β-adrenergic receptor transcription in the occurrence and development of bladder cancer through STAT3 activity5
Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population5
A prospective cohort study of the impact of chronic disease on fall injuries in middle-aged and older adults5
Migraine management: Non-pharmacological points for patients and health care professionals5
Compilation of a self-management assessment scale for postoperative patients with aortic dissection5
miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization5
Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study5
Mean corpuscular hemoglobin predicts the length of hospital stay independent of severity classification in patients with acute pancreatitis5
Atherogenic index of plasma and coronary artery disease: A systematic review5
Adipose-derived stem cells repair radiation-induced chronic lung injury via inhibiting TGF-β1/Smad 3 signaling pathway5
Evaluation of placental oxygenation by near-infrared spectroscopy in relation to ultrasound maturation grade in physiological term pregnancies5
Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients5
Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer5
A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue5
The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals5
Clinical characteristics of current COVID-19 rehabilitation outpatients in China5
The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study5
Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma5
Lycopene ameliorates locomotor activity and urinary frequency induced by pelvic venous congestion in rats5
Visfatin is negatively associated with coronary artery lesions in subjects with impaired fasting glucose5
Changes of microbiota level in urinary tract infections: A meta-analysis5
HPV16 E6E7 up-regulates KIF2A expression by activating JNK/c-Jun signal, is beneficial to migration and invasion of cervical cancer cells5
Upregulated microRNA-429 confers endometrial stromal cell dysfunction by targeting HIF1AN and regulating the HIF1A/VEGF pathway5
PVT1/miR-16/CCND1 axis regulates gastric cancer progression5
Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force5
Differences in complications between hepatitis B-related cirrhosis and alcohol-related cirrhosis5
A case report of dermatomyositis with the missed diagnosis of non-small cell lung cancer and concurrence of pulmonary tuberculosis5
Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction5
Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway5
The effect of AQP4 on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts5
A 16-gene signature associated with homologous recombination deficiency for prognosis prediction in patients with triple-negative breast cancer5
Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates5
Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study5
Identification of autophagy-related biomarkers in patients with pulmonary arterial hypertension based on bioinformatics analysis5
GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma5
lncRNA HAGLR modulates myocardial ischemia–reperfusion injury in mice through regulating miR-133a-3p/MAPK1 axis5
Impact of omicron wave and associated control measures in Shanghai on health management and psychosocial well-being of patients with chronic conditions5
miR-29 regulates metabolism by inhibiting JNK-1 expression in non-obese patients with type 2 diabetes mellitus and NAFLD5
Risk factors of frailty/sarcopenia in community older adults: Meta-analysis5
Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population5
Pathological characteristics of liver injury induced by N,N-dimethylformamide: From humans to animal models5
SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis5
Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells5
Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma5
Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma5
Molecular landscape of borderline ovarian tumours: A systematic review5
Elevated blood acetoacetate levels reduce major adverse cardiac and cerebrovascular events risk in acute myocardial infarction5
Identification of osteoporosis based on gene biomarkers using support vector machine5
Four drug metabolism-related subgroups of pancreatic adenocarcinoma in prognosis, immune infiltration, and gene mutation5
Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina5
The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study5
METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients5
The diagnostic accuracy of touch imprint cytology for sentinel lymph node metastases of breast cancer: An up-to-date meta-analysis of 4,073 patients5
WDR79 promotes aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) by the suppression of SIRT45
CRRT influences PICCO measurements in febrile critically ill patients4
Sox9: A potential regulator of cancer stem cells in osteosarcoma4
Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study4
Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2°C4
Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis4
Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series4
Metformin and estrogen modulation in LABC with T2DM: A 36-month randomized trial4
hsa-miR-340-5p inhibits epithelial–mesenchymal transition in endometriosis by targeting MAP3K2 and inactivating MAPK/ERK signaling4
Population pharmacokinetics of meropenem in critically ill patients4
Genomic analysis of immunogenic cell death-related subtypes for predicting prognosis and immunotherapy outcomes in glioblastoma multiforme4
The relationship between serum CA50, CA242, and SAA levels and clinical pathological characteristics and prognosis in patients with pancreatic cancer4
FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma4
Atypical symptoms of malignant hyperthermia: A rare causative mutation in the RYR1 gene4
Analysis of the clinical characteristics and prognosis of adult de novo acute myeloid leukemia (none APL) with PTPN11 mutations4
Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy4
Delayed graft function after renal transplantation4
Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty4
TGF-β1 upregulates Sar1a expression and induces procollagen-I secretion in hypertrophic scarring fibroblasts4
A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients4
Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery4
Antitumor activity of recombinant oncolytic vaccinia virus with human IL24
Bioinformatics-based analysis of SUMOylation-related genes in hepatocellular carcinoma reveals a role of upregulated SAE1 in promoting cell proliferation4
Effect of miR-499-5p/SOX6 axis on atrial fibrosis in rats with atrial fibrillation4
METTL16 in human diseases: What should we do next?4
Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis4
SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial–mesenchymal transition4
Correlation between microvessel maturity and ISUP grades assessed using contrast-enhanced transrectal ultrasonography in prostate cancer4
Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis4
The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association4
Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis4
Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study4
The function of lncRNA EMX2OS/miR-653-5p and its regulatory mechanism in lung adenocarcinoma4
Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype4
lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells4
The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review4
Identification and external validation of a prognostic signature based on hypoxia–glycolysis-related genes for kidney renal clear cell carcinoma4
Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–20194
NORAD modulates miR-30c-5p-LDHA to protect lung endothelial cells damage4
The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer4
CD36-mediated podocyte lipotoxicity promotes foot process effacement4
The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital4
MicroRNA 322-5p reduced neuronal inflammation via the TLR4/TRAF6/NF-κB axis in a rat epilepsy model4
Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy4
Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”4
Construction of immunogenic cell death-related molecular subtypes and prognostic signature in colorectal cancer4
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